# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Nitroreductase PF00881.19 AIC14184.1 - 8.1e-35 120.0 0.2 1e-34 119.7 0.1 1.1 1 0 0 1 1 1 1 Nitroreductase family HMG_CoA_synt_C PF08540.5 AIC14187.1 - 1.4e-32 113.3 0.1 2.4e-32 112.5 0.1 1.3 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.12 AIC14187.1 - 3.6e-29 101.5 0.1 7.5e-29 100.5 0.0 1.5 2 0 0 2 2 2 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal PALP PF00291.20 AIC14188.1 - 2.3e-81 273.3 4.1 3.1e-81 272.9 2.9 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.20 AIC14188.1 - 0.00016 21.0 0.0 0.00042 19.7 0.0 1.8 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.1 AIC14188.1 - 0.037 14.3 0.0 0.085 13.2 0.0 1.6 1 0 0 1 1 1 0 ACT domain Thr_dehydrat_C PF00585.13 AIC14188.1 - 0.06 12.9 0.0 0.11 12.0 0.0 1.4 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase DUF2024 PF09630.5 AIC14190.1 - 1.1e-33 114.7 1.1 1.2e-33 114.6 0.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) Cytochrom_NNT PF03264.9 AIC14190.1 - 0.067 12.6 0.3 0.071 12.5 0.2 1.1 1 0 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region Lactamase_B PF00753.22 AIC14191.1 - 1.2e-23 83.8 2.8 1.8e-23 83.2 2.0 1.3 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 AIC14191.1 - 0.0089 15.5 0.1 0.013 15.0 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain NHL PF01436.16 AIC14192.1 - 9.5e-27 91.5 0.2 0.00034 20.4 0.0 7.5 7 0 0 7 7 7 5 NHL repeat Redoxin PF08534.5 AIC14192.1 - 1.8e-12 47.0 0.0 1.2e-11 44.3 0.0 2.1 2 0 0 2 2 2 1 Redoxin Thioredoxin_8 PF13905.1 AIC14192.1 - 4.6e-11 42.6 0.1 9.3e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 AIC14192.1 - 7.9e-11 41.7 0.0 1.7e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA family SGL PF08450.7 AIC14192.1 - 5.7e-06 25.8 0.1 0.03 13.7 0.0 3.9 3 1 1 4 4 4 2 SMP-30/Gluconolaconase/LRE-like region Thioredoxin_2 PF13098.1 AIC14192.1 - 2.6e-05 24.4 0.0 5.2e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.15 AIC14192.1 - 0.00028 20.5 0.3 0.091 12.4 0.0 2.6 3 0 0 3 3 3 2 Thioredoxin LVIVD PF08309.6 AIC14192.1 - 0.0037 16.2 4.4 1.4 7.9 0.0 4.8 6 0 0 6 6 6 1 LVIVD repeat TrbC_Ftype PF09673.5 AIC14192.1 - 0.063 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Nitroreductase PF00881.19 AIC14193.1 - 2.9e-26 92.2 0.1 3.6e-26 91.9 0.1 1.1 1 0 0 1 1 1 1 Nitroreductase family DUF432 PF04254.8 AIC14194.1 - 7.1e-31 106.6 0.2 1.3e-30 105.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF432) CorA PF01544.13 AIC14195.1 - 6.1e-61 206.0 0.0 6.9e-61 205.8 0.0 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein TelA PF05816.6 AIC14195.1 - 0.0088 14.7 0.2 0.013 14.1 0.1 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) DUF1351 PF07083.6 AIC14195.1 - 0.015 14.9 0.2 0.021 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) HsdM_N PF12161.3 AIC14195.1 - 0.027 14.9 0.4 0.18 12.2 0.3 2.0 1 1 1 2 2 2 0 HsdM N-terminal domain Baculo_LEF-11 PF06385.7 AIC14195.1 - 0.13 12.3 0.2 0.36 10.9 0.0 1.8 1 1 0 1 1 1 0 Baculovirus LEF-11 protein MS_channel PF00924.13 AIC14196.1 - 3.4e-50 170.2 0.1 3.4e-50 170.2 0.1 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel HeH PF12949.2 AIC14196.1 - 0.02 14.4 0.3 0.44 10.1 0.0 2.6 3 0 0 3 3 3 0 HeH/LEM domain Sdh_cyt PF01127.17 AIC14196.1 - 0.068 12.9 0.4 0.068 12.9 0.2 1.7 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Oleosin PF01277.12 AIC14196.1 - 4.4 6.9 7.9 1.1 8.8 1.0 2.3 2 0 0 2 2 2 0 Oleosin Tad PF13400.1 AIC14196.1 - 9.2 6.3 9.4 3.3 7.8 0.8 2.7 2 0 0 2 2 2 0 Putative Flp pilus-assembly TadE/G-like MFS_1 PF07690.11 AIC14197.1 - 1.1e-29 103.3 39.8 3.5e-18 65.4 10.4 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily HalX PF08663.5 AIC14198.1 - 0.84 9.6 4.4 1.5 8.8 0.2 3.0 3 0 0 3 3 3 0 HalX domain YwpF PF14183.1 AIC14199.1 - 0.012 15.3 0.2 0.051 13.2 0.0 2.0 1 1 0 1 1 1 0 YwpF-like protein AAA PF00004.24 AIC14199.1 - 0.061 13.5 3.9 0.29 11.3 0.6 2.2 1 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF2136 PF09907.4 AIC14200.1 - 0.00059 19.8 0.1 0.00089 19.2 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2136) Plasmid_stabil PF05016.9 AIC14200.1 - 0.0053 17.1 0.1 0.0081 16.5 0.0 1.4 1 0 0 1 1 1 1 Plasmid stabilisation system protein Guanylate_cyc PF00211.15 AIC14201.1 - 9.9e-20 70.6 0.0 1.4e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ribosomal_S9 PF00380.14 AIC14202.1 - 7.9e-32 110.0 0.4 9.1e-32 109.8 0.3 1.0 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13 PF00572.13 AIC14203.1 - 1.5e-25 89.6 0.2 1.9e-25 89.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L13 Ribosomal_L18e PF00828.14 AIC14204.1 - 1.6e-13 51.1 0.4 2.1e-13 50.7 0.3 1.2 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 RNA_pol_A_bac PF01000.21 AIC14205.1 - 2.1e-27 95.4 0.0 5.2e-27 94.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.19 AIC14205.1 - 2.5e-14 52.1 0.0 3e-14 51.8 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L_2 PF13656.1 AIC14205.1 - 0.00033 20.0 0.1 0.00063 19.1 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain Thioredoxin_3 PF13192.1 AIC14205.1 - 0.055 13.2 2.5 2.8 7.8 0.0 3.0 2 1 0 2 2 2 0 Thioredoxin domain SBDS PF01172.13 AIC14206.1 - 1.1e-24 86.0 0.0 1.7e-24 85.3 0.0 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.5 AIC14206.1 - 1.2e-21 76.7 0.2 5.8e-21 74.4 0.0 1.9 2 0 0 2 2 2 1 SBDS protein C-terminal domain XkdN PF08890.6 AIC14206.1 - 0.023 14.4 0.0 0.043 13.5 0.0 1.4 1 0 0 1 1 1 0 Phage XkdN-like protein HD_assoc PF13286.1 AIC14206.1 - 0.058 13.6 1.7 0.68 10.2 0.3 2.9 1 1 2 3 3 3 0 Phosphohydrolase-associated domain EFG_C PF00679.19 AIC14206.1 - 0.059 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Elongation factor G C-terminus KH_1 PF00013.24 AIC14207.1 - 3.5e-12 45.7 2.1 6.5e-12 44.9 1.4 1.4 1 0 0 1 1 1 1 KH domain KH_3 PF13014.1 AIC14207.1 - 5.9e-05 22.6 1.6 0.00017 21.1 1.1 1.8 1 0 0 1 1 1 1 KH domain KH_2 PF07650.12 AIC14207.1 - 0.00047 19.6 1.1 0.00092 18.7 0.3 1.8 1 1 0 1 1 1 1 KH domain TBP PF00352.16 AIC14207.1 - 0.15 11.4 0.3 0.44 9.9 0.1 1.8 2 1 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) RNase_PH PF01138.16 AIC14208.1 - 1.7e-34 118.9 0.0 2.4e-34 118.4 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 AIC14208.1 - 2.5e-15 56.1 0.3 6.5e-15 54.8 0.1 1.8 2 0 0 2 2 2 1 3' exoribonuclease family, domain 2 RNase_PH PF01138.16 AIC14209.1 - 7.8e-27 94.1 0.0 1.2e-26 93.5 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.10 AIC14209.1 - 3e-07 30.2 0.0 6.5e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF3237 PF11578.3 AIC14209.1 - 0.02 14.1 0.0 0.57 9.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3237) Ribosomal_L37ae PF01780.14 AIC14210.1 - 1.6e-15 56.7 1.1 1.7e-15 56.6 0.7 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.2 AIC14210.1 - 8.5e-05 22.2 3.0 0.00012 21.8 2.1 1.2 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC14210.1 - 0.0016 17.6 1.1 0.64 9.3 0.1 2.3 2 0 0 2 2 2 2 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 AIC14210.1 - 0.0042 16.7 0.8 0.0053 16.3 0.6 1.3 1 0 0 1 1 1 1 Putative transposase DNA-binding domain Rubredoxin PF00301.15 AIC14210.1 - 0.011 15.5 0.2 4.1 7.3 0.1 2.2 2 0 0 2 2 2 0 Rubredoxin Zn-ribbon_8 PF09723.5 AIC14210.1 - 0.034 14.0 0.8 0.82 9.6 0.0 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-RanBP PF00641.13 AIC14210.1 - 0.039 13.0 3.9 0.23 10.5 0.4 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zinc_ribbon_2 PF13240.1 AIC14210.1 - 0.052 13.0 2.0 3.5 7.2 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2_4 PF13894.1 AIC14210.1 - 0.072 13.4 0.6 3.8 8.0 0.0 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger C1_1 PF00130.17 AIC14210.1 - 0.077 12.7 0.8 0.11 12.2 0.5 1.1 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4379 PF14311.1 AIC14210.1 - 0.09 12.6 2.2 6 6.7 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4379) zf-ISL3 PF14690.1 AIC14210.1 - 0.091 12.8 3.3 1.2 9.2 0.1 2.5 3 0 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 VP_N-CPKC PF11475.3 AIC14210.1 - 0.096 12.2 3.0 1.1 8.8 0.5 2.2 2 0 0 2 2 2 0 Virion protein N terminal domain zf-C4_Topoisom PF01396.14 AIC14210.1 - 0.13 11.8 3.3 4.9 6.7 0.1 2.6 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger zf-H2C2_2 PF13465.1 AIC14210.1 - 0.16 12.3 0.9 11 6.5 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain DZR PF12773.2 AIC14210.1 - 0.16 11.7 1.8 1.1 9.1 1.3 1.9 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_5 PF13719.1 AIC14210.1 - 0.2 11.2 3.0 6.3 6.4 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain UPF0547 PF10571.4 AIC14210.1 - 0.25 11.0 3.9 6.4 6.5 0.7 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zinc_ribbon_4 PF13717.1 AIC14210.1 - 0.25 11.0 3.0 6.9 6.4 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.6 AIC14210.1 - 0.32 10.5 0.3 0.32 10.5 0.2 2.0 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DNA_ligase_ZBD PF03119.11 AIC14210.1 - 0.41 10.4 4.3 0.88 9.3 0.5 2.3 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-tcix PF14952.1 AIC14210.1 - 0.6 9.4 7.0 2.1 7.7 1.0 2.2 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-CSL PF05207.8 AIC14210.1 - 1.5 8.3 4.3 17 5.0 2.9 2.1 1 1 0 1 1 1 0 CSL zinc finger Pcc1 PF09341.5 AIC14211.1 - 1.6e-12 47.2 0.0 1.8e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 Prefoldin_2 PF01920.15 AIC14212.1 - 4.7e-17 61.6 9.5 5.2e-17 61.5 6.6 1.0 1 0 0 1 1 1 1 Prefoldin subunit Cortex-I_coil PF09304.5 AIC14212.1 - 0.0074 16.3 1.3 0.0074 16.3 0.9 2.1 2 0 0 2 2 2 1 Cortexillin I, coiled coil ETC_C1_NDUFA5 PF04716.9 AIC14212.1 - 0.14 11.6 3.4 1.8 8.1 2.4 2.3 1 1 0 1 1 1 0 ETC complex I subunit conserved region EzrA PF06160.7 AIC14212.1 - 0.15 10.2 3.1 0.16 10.0 2.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DUF2361 PF10153.4 AIC14212.1 - 0.4 10.8 6.6 0.46 10.6 4.6 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2361) APG6 PF04111.7 AIC14212.1 - 0.81 8.6 5.1 0.99 8.3 3.6 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 CDC37_N PF03234.9 AIC14212.1 - 5.4 7.2 7.1 9.1 6.5 4.9 1.4 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding ERCC4 PF02732.10 AIC14213.1 - 8.9e-22 77.3 0.0 1.3e-21 76.8 0.0 1.3 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.1 AIC14213.1 - 2.1e-09 37.4 0.3 8.4e-09 35.4 0.0 2.0 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.2 AIC14213.1 - 9.9e-06 25.3 0.0 3.1e-05 23.7 0.0 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH PF00633.18 AIC14213.1 - 0.00029 20.3 0.1 1 9.1 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_8 PF14716.1 AIC14213.1 - 0.0014 18.7 0.1 2.1 8.5 0.0 3.2 2 1 1 3 3 3 2 Helix-hairpin-helix domain IMS_HHH PF11798.3 AIC14213.1 - 0.0045 16.9 0.1 0.069 13.2 0.0 2.7 3 0 0 3 3 3 1 IMS family HHH motif HHH_3 PF12836.2 AIC14213.1 - 0.017 15.0 0.1 4 7.4 0.0 2.5 2 0 0 2 2 2 0 Helix-hairpin-helix motif Transposase_20 PF02371.11 AIC14213.1 - 0.027 14.5 0.0 0.34 11.0 0.0 2.3 1 1 1 2 2 2 0 Transposase IS116/IS110/IS902 family Rhodanese PF00581.15 AIC14214.1 - 3.4e-37 127.2 0.0 2e-18 66.7 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain PIN PF01850.16 AIC14215.1 - 1.3e-05 25.5 2.0 1.9e-05 24.9 1.4 1.3 1 0 0 1 1 1 1 PIN domain NOB1_Zn_bind PF08772.6 AIC14215.1 - 0.00029 20.5 1.2 0.00047 19.9 0.8 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like UPF0278 PF08745.6 AIC14215.1 - 0.00078 18.7 0.2 0.0013 17.9 0.2 1.3 1 0 0 1 1 1 1 UPF0278 family DZR PF12773.2 AIC14215.1 - 0.0025 17.5 0.6 0.0042 16.8 0.4 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-C3HC4_3 PF13920.1 AIC14215.1 - 0.021 14.4 1.1 0.034 13.8 0.7 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.1 AIC14215.1 - 0.027 13.6 1.9 0.044 13.0 1.3 1.4 1 0 0 1 1 1 0 zinc-ribbon domain FdhE PF04216.7 AIC14215.1 - 0.055 13.1 2.2 0.056 13.1 0.9 1.4 1 1 0 1 1 1 0 Protein involved in formate dehydrogenase formation DUF35_N PF12172.3 AIC14215.1 - 0.087 12.7 1.0 0.2 11.5 0.7 1.5 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) HypA PF01155.14 AIC14215.1 - 0.094 12.4 0.6 0.15 11.7 0.4 1.5 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DUF2116 PF09889.4 AIC14215.1 - 0.22 11.3 0.9 0.38 10.5 0.6 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Nudix_N_2 PF14803.1 AIC14215.1 - 0.23 11.2 2.2 7.3 6.3 0.2 2.3 2 0 0 2 2 2 0 Nudix N-terminal zf-C4_Topoisom PF01396.14 AIC14215.1 - 0.74 9.3 3.8 0.21 11.1 0.5 1.7 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger NAD_kinase PF01513.16 AIC14216.1 - 2.2e-31 108.6 0.6 3.7e-31 107.9 0.4 1.3 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.19 AIC14216.1 - 0.12 11.8 0.3 0.27 10.6 0.2 1.6 1 1 0 1 1 1 0 Diacylglycerol kinase catalytic domain Rhodanese PF00581.15 AIC14217.1 - 1.1e-43 148.1 0.1 2.2e-25 89.2 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Fer4 PF00037.22 AIC14219.1 - 8.1e-09 34.7 17.9 0.00016 21.1 2.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 AIC14219.1 - 6.1e-07 29.7 7.7 1.3e-06 28.6 5.3 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 AIC14219.1 - 6.9e-07 29.4 6.8 1.6e-06 28.2 4.7 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 AIC14219.1 - 6.9e-05 22.5 8.7 0.00016 21.3 6.0 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 AIC14219.1 - 8.3e-05 22.3 7.7 0.00014 21.6 5.4 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 AIC14219.1 - 0.00014 21.8 6.3 0.00026 20.9 4.0 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.1 AIC14219.1 - 0.00024 21.4 3.6 0.13 12.6 0.3 2.6 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.2 AIC14219.1 - 0.00041 20.0 13.9 0.082 12.8 2.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.2 AIC14219.1 - 0.0045 16.8 14.5 0.22 11.4 1.4 2.5 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_3 PF12798.2 AIC14219.1 - 0.026 15.0 16.8 0.47 11.1 2.4 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_4 PF12800.2 AIC14219.1 - 0.086 13.2 11.3 0.52 10.7 1.2 2.6 2 1 0 2 2 2 0 4Fe-4S binding domain MSP1_C PF07462.6 AIC14219.1 - 0.11 10.8 1.4 0.15 10.4 1.0 1.1 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF2360 PF10152.4 AIC14219.1 - 0.27 11.5 1.9 0.4 10.9 1.3 1.3 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) Fer4_17 PF13534.1 AIC14219.1 - 0.39 11.0 8.8 4.7 7.6 0.4 2.5 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_16 PF13484.1 AIC14219.1 - 0.45 11.3 9.9 2.5 8.8 1.7 2.6 1 1 1 2 2 2 0 4Fe-4S double cluster binding domain Fer4_15 PF13459.1 AIC14219.1 - 0.5 10.9 10.2 1.7 9.2 1.1 2.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_13 PF13370.1 AIC14219.1 - 0.71 10.3 10.1 1.3 9.5 0.6 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain CTP_transf_2 PF01467.21 AIC14220.1 - 1.3e-11 44.7 0.0 2.4e-10 40.6 0.0 2.0 1 1 0 1 1 1 1 Cytidylyltransferase FAD_syn PF06574.7 AIC14220.1 - 0.0049 16.5 0.3 0.013 15.1 0.1 1.7 2 0 0 2 2 2 1 FAD synthetase DUF241 PF03087.9 AIC14220.1 - 0.082 12.3 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Arabidopsis protein of unknown function tRNA-synt_1b PF00579.20 AIC14223.1 - 6.3e-22 78.0 0.0 1.1e-21 77.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.13 AIC14223.1 - 0.039 12.6 0.0 0.069 11.8 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) tRNA-synt_2d PF01409.15 AIC14224.1 - 1.8e-85 286.0 0.0 2.3e-85 285.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.15 AIC14224.1 - 5.8e-06 25.3 0.5 0.0013 17.6 0.0 3.1 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.20 AIC14224.1 - 0.0014 18.2 0.1 0.004 16.7 0.0 1.7 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HTH_20 PF12840.2 AIC14224.1 - 0.037 13.8 0.0 0.13 12.0 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain B5 PF03484.10 AIC14225.1 - 4.8e-19 67.9 0.1 1.1e-17 63.6 0.0 2.6 2 0 0 2 2 2 1 tRNA synthetase B5 domain B3_4 PF03483.12 AIC14225.1 - 9.3e-14 51.2 0.0 1.6e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain RolB_RolC PF02027.12 AIC14225.1 - 0.084 12.0 0.0 0.14 11.2 0.0 1.4 1 1 0 1 1 1 0 RolB/RolC glucosidase family KOW PF00467.24 AIC14225.1 - 3.6 7.4 5.4 1.9 8.3 0.4 2.8 3 0 0 3 3 3 0 KOW motif ThiI PF02568.9 AIC14226.1 - 5.7e-15 55.2 0.0 9e-15 54.6 0.0 1.2 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.11 AIC14226.1 - 5e-12 45.0 0.0 1.2e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 tRNA methyl transferase DUF814 PF05670.8 AIC14226.1 - 1.5e-08 34.4 0.0 3.7e-08 33.1 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF814) Asn_synthase PF00733.16 AIC14226.1 - 3e-05 23.6 0.0 4.5e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 AIC14226.1 - 0.0023 17.2 0.0 0.0044 16.3 0.0 1.5 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC HTH_23 PF13384.1 AIC14226.1 - 0.074 12.7 0.0 0.22 11.2 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain NAD_synthase PF02540.12 AIC14226.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 NAD synthase Terminase_5 PF06056.7 AIC14226.1 - 0.15 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) DUF552 PF04472.7 AIC14227.1 - 5.7e-17 61.3 0.1 6.6e-17 61.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF552) FluMu_gp41 PF10109.4 AIC14227.1 - 0.068 13.1 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Mu-like prophage FluMu protein gp41 Flu_M1_C PF08289.6 AIC14227.1 - 0.1 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Influenza Matrix protein (M1) C-terminal domain Beta-Casp PF10996.3 AIC14228.1 - 8.8e-23 80.6 0.0 5.3e-22 78.0 0.0 2.3 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B PF00753.22 AIC14228.1 - 1.2e-21 77.3 0.1 1.9e-21 76.6 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 AIC14228.1 - 4.1e-11 42.7 0.0 8.9e-11 41.6 0.0 1.6 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.7 AIC14228.1 - 6.3e-11 41.9 0.0 1.7e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 AIC14228.1 - 0.0011 18.7 0.0 0.0027 17.4 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Trans_reg_C PF00486.23 AIC14228.1 - 0.12 12.3 0.0 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulatory protein, C terminal TRAM PF01938.15 AIC14229.1 - 2e-11 43.5 0.4 2.6e-11 43.1 0.3 1.2 1 0 0 1 1 1 1 TRAM domain Fe-ADH_2 PF13685.1 AIC14230.1 - 1.6e-61 207.8 0.0 2.2e-61 207.3 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.14 AIC14230.1 - 1.9e-24 86.0 0.5 6.5e-24 84.2 0.3 1.7 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.15 AIC14230.1 - 2e-08 33.5 0.0 3.6e-07 29.3 0.0 2.6 1 1 0 1 1 1 1 3-dehydroquinate synthase AIRC PF00731.15 AIC14230.1 - 0.034 13.4 0.2 0.14 11.4 0.0 2.0 2 0 0 2 2 2 0 AIR carboxylase Polyketide_cyc PF03364.15 AIC14231.1 - 1.5e-09 37.9 0.0 1.9e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.4 AIC14231.1 - 1.8e-08 34.6 0.1 2.1e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF99 PF01949.11 AIC14232.1 - 7.7e-57 191.4 0.0 8.6e-57 191.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF99 GTP_EFTU_D2 PF03144.20 AIC14233.1 - 3.4e-08 33.4 0.1 7.6e-08 32.3 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 AIC14233.1 - 0.021 14.4 0.1 0.052 13.1 0.1 1.7 1 0 0 1 1 1 0 Elongation factor Tu domain 4 PKD PF00801.15 AIC14234.1 - 5.1e-16 58.1 1.7 5.1e-16 58.1 1.2 1.6 2 0 0 2 2 2 1 PKD domain Big_3_4 PF13754.1 AIC14234.1 - 0.0019 18.4 6.5 0.0042 17.3 4.5 1.6 1 1 0 1 1 1 1 Bacterial Ig-like domain (group 3) COX4 PF02936.9 AIC14234.1 - 0.014 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV He_PIG PF05345.7 AIC14234.1 - 0.47 10.5 2.9 0.26 11.3 0.5 1.8 2 0 0 2 2 2 0 Putative Ig domain Cu-oxidase_3 PF07732.10 AIC14236.1 - 1.4e-12 47.3 0.6 3.2e-12 46.2 0.4 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.9 AIC14236.1 - 6.4e-06 25.7 2.9 0.0011 18.4 0.1 3.2 3 1 1 4 4 4 2 Multicopper oxidase Cupredoxin_1 PF13473.1 AIC14236.1 - 0.0012 18.6 0.0 0.0027 17.5 0.0 1.5 1 0 0 1 1 1 1 Cupredoxin-like domain AmoC PF04896.7 AIC14237.1 - 6.9e-16 58.0 6.4 8.4e-16 57.7 4.5 1.0 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C NMN_transporter PF04973.7 AIC14237.1 - 1.2 8.5 9.4 0.64 9.4 4.5 1.9 1 1 1 2 2 2 0 Nicotinamide mononucleotide transporter OAD_gamma PF04277.8 AIC14237.1 - 1.2 9.5 0.0 1.2 9.5 0.0 2.5 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain zinc_ribbon_5 PF13719.1 AIC14238.1 - 0.0016 17.9 1.4 0.23 11.0 0.2 2.4 2 0 0 2 2 2 2 zinc-ribbon domain Tmemb_55A PF09788.4 AIC14238.1 - 0.027 13.6 0.2 0.031 13.4 0.2 1.0 1 0 0 1 1 1 0 Transmembrane protein 55A zinc_ribbon_4 PF13717.1 AIC14238.1 - 0.047 13.3 3.2 1.6 8.5 0.3 2.4 2 0 0 2 2 2 0 zinc-ribbon domain CFC PF09443.5 AIC14238.1 - 0.53 9.9 6.4 0.14 11.8 1.4 1.9 2 0 0 2 2 2 0 Cripto_Frl-1_Cryptic (CFC) CARDB PF07705.6 AIC14240.1 - 0.006 16.6 0.3 0.02 14.9 0.1 1.8 2 0 0 2 2 2 1 CARDB DUF2393 PF09624.5 AIC14240.1 - 0.019 14.5 0.0 0.037 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) DUF217 PF02697.9 AIC14241.1 - 0.002 18.3 0.3 0.012 15.8 0.2 1.9 1 1 0 1 1 1 1 Uncharacterized ACR, COG1753 Zip PF02535.17 AIC14242.1 - 1.5e-07 30.7 13.1 1.5e-07 30.7 9.1 2.6 1 1 1 3 3 3 1 ZIP Zinc transporter Ldr_toxin PF13940.1 AIC14242.1 - 0.17 11.6 0.2 0.17 11.6 0.1 2.6 3 0 0 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system Borrelia_P13 PF05628.7 AIC14242.1 - 5.5 6.8 8.2 1.2 8.9 2.3 2.4 1 1 1 2 2 2 0 Borrelia membrane protein P13 Cu-oxidase_3 PF07732.10 AIC14243.1 - 4.9e-28 97.2 3.0 6.5e-24 83.9 0.1 2.4 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 AIC14243.1 - 4.3e-27 94.3 4.6 4.8e-12 45.5 0.1 3.2 3 0 0 3 3 3 3 Multicopper oxidase Cupredoxin_1 PF13473.1 AIC14243.1 - 0.00026 20.8 0.1 0.016 15.0 0.0 2.5 3 0 0 3 3 3 1 Cupredoxin-like domain DUF309 PF03745.9 AIC14244.1 - 2.7e-17 61.9 0.6 5.3e-17 61.0 0.3 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF309) Imm22 PF15592.1 AIC14244.1 - 0.044 14.1 0.0 0.089 13.1 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 22 DUF2393 PF09624.5 AIC14245.1 - 8.8e-05 22.0 0.1 0.17 11.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2393) DUF3426 PF11906.3 AIC14245.1 - 0.0069 16.0 0.4 0.21 11.2 0.0 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF3426) DUF3124 PF11322.3 AIC14245.1 - 0.032 14.1 0.2 4.7 7.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3124) Pribosyltran_N PF13793.1 AIC14246.1 - 7.1e-30 103.1 0.5 1.5e-28 98.8 0.0 2.3 2 1 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.1 AIC14246.1 - 1.1e-19 70.9 2.6 1.4e-18 67.3 0.6 2.7 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.22 AIC14246.1 - 3.1e-14 52.7 2.6 4.9e-14 52.1 0.1 2.5 3 0 0 3 3 3 1 Phosphoribosyl transferase domain UPRTase PF14681.1 AIC14246.1 - 5.3e-06 25.7 0.0 8.2e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Lactamase_B_2 PF12706.2 AIC14247.1 - 2.3e-28 99.0 0.0 3.2e-28 98.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 AIC14247.1 - 4.3e-09 36.3 0.0 8.4e-08 32.0 0.0 2.2 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.1 AIC14247.1 - 0.00061 19.2 0.0 0.0013 18.1 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease Metallophos PF00149.23 AIC14248.1 - 2.3e-20 72.8 0.1 5.9e-20 71.5 0.1 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.2 AIC14248.1 - 1.4e-06 28.2 0.0 2.6e-06 27.3 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain DUF2420 PF10336.4 AIC14249.1 - 0.11 12.0 0.0 1.3 8.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2420) Ribosomal_L32e PF01655.13 AIC14250.1 - 1.2e-40 137.9 0.9 1.5e-40 137.6 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Ribosomal_L19e PF01280.15 AIC14251.1 - 6.2e-41 139.6 10.1 6.9e-41 139.4 7.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L19e HTH_12 PF08461.5 AIC14251.1 - 0.0057 16.3 0.3 0.012 15.3 0.2 1.5 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain DNA_binding_1 PF01035.15 AIC14252.1 - 1.6e-31 107.8 0.0 2.2e-31 107.4 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain tRNA_deacylase PF04414.7 AIC14253.1 - 4.3e-61 205.7 0.0 5e-61 205.5 0.0 1.0 1 0 0 1 1 1 1 D-aminoacyl-tRNA deacylase SseB_C PF14581.1 AIC14253.1 - 0.12 12.1 0.0 1.4 8.7 0.0 2.1 2 0 0 2 2 2 0 SseB protein C-terminal domain Spt5-NGN PF03439.8 AIC14254.1 - 1.5e-21 75.9 0.0 2.3e-21 75.3 0.0 1.3 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.24 AIC14254.1 - 7.6e-08 31.7 0.1 1.6e-07 30.7 0.1 1.6 1 0 0 1 1 1 1 KOW motif NusG PF02357.14 AIC14254.1 - 0.0039 17.4 0.0 0.0085 16.3 0.0 1.6 1 1 0 1 1 1 1 Transcription termination factor nusG BNIP2 PF12496.3 AIC14254.1 - 0.029 14.5 2.9 0.045 13.9 2.0 1.3 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 DUF2890 PF11081.3 AIC14254.1 - 0.13 12.2 4.7 0.16 11.9 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Nop14 PF04147.7 AIC14254.1 - 0.35 8.7 6.6 0.44 8.3 4.6 1.0 1 0 0 1 1 1 0 Nop14-like family Stm1_N PF09598.5 AIC14254.1 - 2.7 8.7 9.3 6.2 7.6 6.5 1.6 1 0 0 1 1 1 0 Stm1 NAD_binding_7 PF13241.1 AIC14255.1 - 9.8e-21 73.9 0.0 2.4e-20 72.7 0.0 1.6 2 0 0 2 2 2 1 Putative NAD(P)-binding Shikimate_DH PF01488.15 AIC14255.1 - 0.00061 19.8 0.9 0.0017 18.4 0.2 2.0 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 AIC14255.1 - 0.0038 17.2 0.0 0.0076 16.2 0.0 1.6 1 1 0 1 1 1 1 TrkA-N domain Sirohm_synth_M PF14824.1 AIC14255.1 - 0.0074 15.2 0.2 0.017 14.1 0.1 1.6 1 0 0 1 1 1 1 Sirohaem biosynthesis protein central Pyr_redox PF00070.22 AIC14255.1 - 0.014 15.7 1.2 0.077 13.4 0.1 2.4 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.9 AIC14255.1 - 0.083 12.7 0.1 0.3 10.9 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase GlutR_N PF05201.10 AIC14256.1 - 3.8e-40 136.9 0.2 7.2e-40 136.0 0.1 1.5 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.15 AIC14256.1 - 1.1e-24 87.0 0.0 3e-24 85.6 0.0 1.8 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.15 AIC14256.1 - 2.6e-16 59.3 0.1 5.4e-16 58.3 0.1 1.5 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain 2-Hacid_dh_C PF02826.14 AIC14256.1 - 0.0018 17.4 0.0 0.0034 16.5 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.1 AIC14256.1 - 0.046 13.9 0.3 0.16 12.2 0.0 2.2 2 1 0 2 2 2 0 Putative NAD(P)-binding ALAD PF00490.16 AIC14257.1 - 4.8e-134 446.3 0.0 5.4e-134 446.1 0.0 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Peripla_BP_4 PF13407.1 AIC14257.1 - 0.11 11.8 0.8 1.9 7.7 0.0 2.6 2 1 1 3 3 3 0 Periplasmic binding protein domain DUF354 PF04007.7 AIC14257.1 - 0.14 11.0 0.0 0.39 9.5 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF354) Sugarporin_N PF11471.3 AIC14259.1 - 0.089 12.4 2.2 0.49 10.0 1.5 2.2 1 1 0 1 1 1 0 Maltoporin periplasmic N-terminal extension PLDc_2 PF13091.1 AIC14260.1 - 0.042 13.5 0.1 0.13 11.9 0.0 1.9 2 0 0 2 2 2 0 PLD-like domain EF-hand_7 PF13499.1 AIC14260.1 - 0.088 12.9 0.1 0.26 11.4 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair YkyB PF14177.1 AIC14261.1 - 0.038 14.1 0.1 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 YkyB-like protein Clr5 PF14420.1 AIC14261.1 - 0.047 13.5 0.2 0.072 12.9 0.1 1.3 1 0 0 1 1 1 0 Clr5 domain zf-FPG_IleRS PF06827.9 AIC14263.1 - 0.018 14.7 3.0 0.028 14.0 2.0 1.4 1 0 0 1 1 1 0 Zinc finger found in FPG and IleRS Ribosomal_60s PF00428.14 AIC14263.1 - 1.2 9.5 7.9 1.6 9.1 5.5 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-ribbon_3 PF13248.1 AIC14263.1 - 5.5 6.3 8.0 0.86 8.8 2.5 2.0 2 1 0 2 2 2 0 zinc-ribbon domain Oleosin PF01277.12 AIC14266.1 - 0.043 13.3 0.0 0.12 11.9 0.0 1.6 2 0 0 2 2 2 0 Oleosin AAA_22 PF13401.1 AIC14267.1 - 0.054 13.6 0.1 0.46 10.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain DUF1779 PF08680.5 AIC14267.1 - 0.074 12.9 0.0 2.1 8.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1779) Glyco_tranf_2_3 PF13641.1 AIC14269.1 - 4.9e-38 131.1 0.1 8.4e-38 130.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 AIC14269.1 - 3.8e-22 78.9 1.2 3.8e-22 78.9 0.8 2.1 3 0 0 3 3 3 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 AIC14269.1 - 8.2e-20 71.1 0.0 1.7e-19 70.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 AIC14269.1 - 2.7e-16 59.3 0.1 4.8e-16 58.5 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 AIC14269.1 - 0.0076 15.3 0.1 0.017 14.2 0.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Cellulose_synt PF03552.9 AIC14269.1 - 0.022 13.0 0.9 0.024 12.9 0.1 1.6 2 0 0 2 2 2 0 Cellulose synthase Chordopox_G3 PF06129.7 AIC14269.1 - 0.16 12.1 0.6 1.5 8.9 0.2 2.4 1 1 1 2 2 2 0 Chordopoxvirus G3 protein DUF1467 PF07330.7 AIC14269.1 - 0.76 9.5 4.1 11 5.8 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1467) Fer4 PF00037.22 AIC14270.1 - 6e-08 31.9 22.9 0.0001 21.7 2.3 2.8 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_9 PF13187.1 AIC14270.1 - 8.8e-07 29.0 6.8 8.8e-07 29.0 4.7 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 AIC14270.1 - 2.1e-06 28.0 9.2 2.1e-06 28.0 6.4 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 AIC14270.1 - 3.4e-05 23.5 19.3 0.00013 21.6 6.4 2.2 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 AIC14270.1 - 7.3e-05 22.5 7.7 7.3e-05 22.5 5.4 2.0 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_8 PF13183.1 AIC14270.1 - 0.00017 21.5 6.0 0.00017 21.5 4.2 2.2 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_18 PF13746.1 AIC14270.1 - 0.0017 18.6 8.9 0.081 13.3 0.3 3.1 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_6 PF12837.2 AIC14270.1 - 0.0086 15.9 20.6 0.052 13.4 2.6 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_2 PF12797.2 AIC14270.1 - 0.028 14.3 19.2 0.14 12.1 1.4 2.9 3 0 0 3 3 3 0 4Fe-4S binding domain DUF3279 PF11682.3 AIC14270.1 - 0.13 11.8 0.1 0.13 11.8 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3279) Fer4_15 PF13459.1 AIC14270.1 - 0.15 12.6 9.5 1.1 9.9 1.1 2.6 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_13 PF13370.1 AIC14270.1 - 0.2 12.0 9.8 0.75 10.2 0.6 2.8 2 0 0 2 2 2 0 4Fe-4S single cluster domain HpaP PF09483.5 AIC14270.1 - 0.29 11.0 8.1 0.42 10.5 5.6 1.2 1 0 0 1 1 1 0 Type III secretion protein (HpaP) Fer4_4 PF12800.2 AIC14270.1 - 0.51 10.8 16.7 0.33 11.3 1.2 3.4 3 1 0 3 3 3 0 4Fe-4S binding domain Fer4_17 PF13534.1 AIC14270.1 - 0.71 10.2 11.9 2 8.8 0.3 2.8 2 1 1 3 3 3 0 4Fe-4S dicluster domain Fer4_3 PF12798.2 AIC14270.1 - 1.2 9.9 24.3 0.3 11.7 2.4 3.0 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_16 PF13484.1 AIC14270.1 - 3.3 8.5 14.4 1.3 9.7 1.7 2.8 2 1 1 3 3 2 0 4Fe-4S double cluster binding domain DUF2360 PF10152.4 AIC14270.1 - 4 7.7 5.0 6 7.1 3.5 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) TPP_enzyme_N PF02776.13 AIC14271.1 - 3e-50 170.0 2.2 1.3e-48 164.7 0.0 2.6 3 0 0 3 3 3 2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 AIC14271.1 - 1.9e-42 144.4 0.5 1.4e-41 141.6 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.17 AIC14271.1 - 5.5e-30 103.9 0.1 1.2e-29 102.7 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.14 AIC14271.1 - 0.00023 20.7 0.1 0.00046 19.7 0.1 1.5 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Peptidase_M55 PF04951.8 AIC14271.1 - 0.089 11.9 0.0 8.4 5.5 0.0 2.8 3 0 0 3 3 3 0 D-aminopeptidase VIT1 PF01988.14 AIC14272.1 - 1.4e-14 54.1 11.8 2e-14 53.6 8.2 1.2 1 0 0 1 1 1 1 VIT family GtrA PF04138.9 AIC14272.1 - 4.7 7.1 6.5 1 9.3 2.2 1.5 2 0 0 2 2 2 0 GtrA-like protein TrmB PF01978.14 AIC14273.1 - 2.8e-15 55.7 0.2 7.1e-15 54.4 0.1 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 AIC14273.1 - 3.3e-10 39.3 0.4 4.3e-06 25.8 0.1 2.2 2 0 0 2 2 2 2 Archaeal transcriptional regulator TrmB PLDc_2 PF13091.1 AIC14273.1 - 0.00024 20.8 0.6 0.54 10.0 0.0 3.3 3 1 1 4 4 4 2 PLD-like domain HTH_5 PF01022.15 AIC14273.1 - 0.00092 18.8 0.2 0.0064 16.1 0.0 2.2 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_IclR PF09339.5 AIC14273.1 - 0.0015 18.0 0.6 0.016 14.7 0.3 2.6 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.17 AIC14273.1 - 0.0025 17.4 0.2 0.0081 15.8 0.2 1.9 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.2 AIC14273.1 - 0.0043 16.7 0.2 0.013 15.1 0.1 1.9 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.15 AIC14273.1 - 0.014 15.4 0.2 0.054 13.6 0.1 2.0 1 0 0 1 1 1 0 Transcriptional regulator PadR PF03551.9 AIC14273.1 - 0.022 14.4 0.0 0.058 13.1 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_24 PF13412.1 AIC14273.1 - 0.035 13.4 0.7 0.097 12.0 0.2 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.1 AIC14273.1 - 0.056 13.2 0.1 0.17 11.6 0.0 1.8 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_20 PF12840.2 AIC14273.1 - 0.067 13.0 0.7 0.15 11.9 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain Peptidase_M10 PF00413.19 AIC14274.1 - 1.8e-14 53.7 0.0 2.6e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.1 AIC14274.1 - 0.00013 21.6 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.1 AIC14274.1 - 0.00054 20.4 0.2 0.00078 19.9 0.1 1.4 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.1 AIC14274.1 - 0.00086 19.2 0.2 0.00096 19.1 0.2 1.3 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.1 AIC14274.1 - 0.0014 18.7 0.0 0.0021 18.1 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M54 PF07998.6 AIC14274.1 - 0.0091 15.7 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M54 DUF45 PF01863.12 AIC14274.1 - 0.011 15.5 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 DUF3152 PF11350.3 AIC14274.1 - 0.023 14.2 0.2 0.052 13.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3152) Peptidase_M57 PF12388.3 AIC14274.1 - 0.029 13.6 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Peptidase_M66 PF10462.4 AIC14274.1 - 0.043 12.6 0.3 0.069 12.0 0.2 1.3 1 0 0 1 1 1 0 Peptidase M66 Peptidase_M43 PF05572.8 AIC14274.1 - 0.049 13.2 0.0 0.077 12.5 0.0 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Astacin PF01400.19 AIC14274.1 - 0.057 12.8 0.0 0.086 12.2 0.0 1.2 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) DUF533 PF04391.7 AIC14274.1 - 0.062 12.6 0.1 0.099 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF533) Reprolysin PF01421.14 AIC14274.1 - 0.064 12.8 0.0 0.085 12.4 0.0 1.2 1 0 0 1 1 1 0 Reprolysin (M12B) family zinc metalloprotease Metallopep PF12044.3 AIC14274.1 - 0.12 10.8 0.2 0.17 10.2 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family DUF11 PF01345.13 AIC14275.1 - 0.024 14.6 0.8 1.1 9.3 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function DUF11 V4R PF02830.13 AIC14276.1 - 9.6e-13 47.7 0.3 1.9e-12 46.8 0.1 1.6 2 0 0 2 2 2 1 V4R domain HTH_24 PF13412.1 AIC14276.1 - 0.00046 19.5 0.0 0.00094 18.5 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_CodY PF08222.6 AIC14276.1 - 0.0028 16.9 0.1 0.0077 15.5 0.1 1.7 1 0 0 1 1 1 1 CodY helix-turn-helix domain HTH_20 PF12840.2 AIC14276.1 - 0.0043 16.8 0.0 0.0089 15.8 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_34 PF13601.1 AIC14276.1 - 0.015 15.3 0.0 0.03 14.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain Rrf2 PF02082.15 AIC14276.1 - 0.031 14.3 0.0 0.055 13.5 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator DUF4085 PF13315.1 AIC14276.1 - 0.042 13.2 0.2 0.068 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) HTH_Crp_2 PF13545.1 AIC14276.1 - 0.044 13.5 0.0 0.087 12.6 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_5 PF01022.15 AIC14276.1 - 0.086 12.5 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DUF3681 PF12442.3 AIC14277.1 - 0.013 15.6 0.0 0.014 15.5 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3681) OppC_N PF12911.2 AIC14277.1 - 0.091 12.1 0.3 0.12 11.7 0.2 1.1 1 0 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DUF2749 PF10907.3 AIC14277.1 - 0.12 12.2 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) DUF1049 PF06305.6 AIC14277.1 - 0.13 11.7 0.5 0.16 11.4 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) IncA PF04156.9 AIC14277.1 - 0.27 10.8 4.2 0.31 10.6 2.9 1.1 1 0 0 1 1 1 0 IncA protein NUT_N PF12881.2 AIC14278.1 - 0.11 11.5 1.2 0.13 11.3 0.4 1.4 1 1 0 1 1 1 0 NUT protein N terminus DUF3869 PF12985.2 AIC14279.1 - 0.1 13.0 0.7 0.16 12.4 0.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3869) AWPM-19 PF05512.6 AIC14280.1 - 0.00057 19.8 0.2 0.011 15.7 0.0 2.1 2 1 0 2 2 2 1 AWPM-19-like family DUF2613 PF11021.3 AIC14280.1 - 0.88 9.3 5.2 18 5.1 3.6 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2613) PKD PF00801.15 AIC14281.1 - 2.5e-19 68.7 96.6 2.1e-08 33.7 2.5 9.8 9 0 0 9 9 9 6 PKD domain HemolysinCabind PF00353.14 AIC14281.1 - 8.7e-13 47.4 134.3 0.0002 21.4 3.8 13.7 7 3 7 17 17 17 12 Hemolysin-type calcium-binding repeat (2 copies) Y_Y_Y PF07495.8 AIC14281.1 - 8e-07 28.7 2.4 0.076 12.7 0.0 5.6 5 0 0 5 5 5 2 Y_Y_Y domain Lyase_N PF09092.6 AIC14281.1 - 0.0013 18.4 0.0 4 7.0 0.0 4.6 6 0 0 6 6 6 1 Lyase, N terminal PKD PF00801.15 AIC14282.1 - 1.2e-17 63.4 25.1 3.9e-09 36.1 2.1 4.7 4 0 0 4 4 4 4 PKD domain HemolysinCabind PF00353.14 AIC14282.1 - 2.5e-07 30.4 58.7 0.004 17.3 0.2 7.6 7 0 0 7 7 7 4 Hemolysin-type calcium-binding repeat (2 copies) VCBS PF13517.1 AIC14282.1 - 0.00046 20.4 14.4 8.3 6.8 0.0 6.2 6 0 0 6 6 6 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 AIC14282.1 - 0.00059 19.4 13.6 2.9 7.6 0.4 6.3 6 0 0 6 6 6 3 FG-GAP repeat FlaE PF07559.9 AIC14282.1 - 0.36 11.4 19.4 4.4 7.9 0.7 4.2 3 1 0 4 4 4 0 Flagellar basal body protein FlaE AMP-binding_C_2 PF14535.1 AIC14283.1 - 0.54 10.3 6.4 72 3.5 0.0 7.3 5 1 2 7 7 7 0 AMP-binding enzyme C-terminal domain DUF4131 PF13567.1 AIC14284.1 - 0.036 13.4 0.9 3 7.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) CBM49 PF09478.5 AIC14284.1 - 0.097 12.7 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 HATPase_c PF02518.21 AIC14285.1 - 1e-24 86.3 0.1 2.2e-24 85.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 AIC14285.1 - 7.3e-12 45.1 3.1 8.6e-12 44.8 0.3 2.4 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.1 AIC14285.1 - 0.0012 18.5 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.1 AIC14285.1 - 0.0013 18.3 1.1 0.0027 17.3 0.0 2.0 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Sigma_reg_N PF13800.1 AIC14285.1 - 0.34 10.9 2.5 9 6.3 0.1 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF1654 PF07867.6 AIC14286.1 - 0.093 12.1 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) RHH_1 PF01402.16 AIC14288.1 - 5.1e-05 22.9 0.1 5.9e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family DUF217 PF02697.9 AIC14288.1 - 0.049 13.8 0.0 0.056 13.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized ACR, COG1753 DUF2969 PF11184.3 AIC14288.1 - 0.11 12.5 0.0 0.13 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2969) RHH_2 PF03693.9 AIC14289.1 - 0.0078 16.3 0.0 0.0078 16.3 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0156) RHH_1 PF01402.16 AIC14289.1 - 0.013 15.3 0.0 0.015 15.1 0.0 1.1 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family DUF4440 PF14534.1 AIC14290.1 - 7e-14 51.9 0.0 8.1e-14 51.7 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.1 AIC14290.1 - 7e-07 29.3 0.0 9.4e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.2 AIC14290.1 - 8.5e-06 26.1 0.0 1.1e-05 25.7 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.1 AIC14290.1 - 4.4e-05 23.3 0.0 0.0001 22.2 0.0 1.5 1 1 0 1 1 1 1 SnoaL-like domain Arch_ATPase PF01637.13 AIC14294.1 - 1.9e-05 24.5 0.0 0.00031 20.5 0.0 2.1 1 1 1 2 2 2 1 Archaeal ATPase AAA_16 PF13191.1 AIC14294.1 - 5.1e-05 23.3 0.0 8.5e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.17 AIC14294.1 - 0.0016 17.3 0.0 0.0028 16.5 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_25 PF13481.1 AIC14294.1 - 0.0016 17.8 0.0 0.0029 17.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.1 AIC14294.1 - 0.024 14.2 0.0 0.054 13.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA PF00004.24 AIC14294.1 - 0.036 14.2 0.0 1.2 9.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 AIC14294.1 - 0.096 11.6 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.7 AIC14294.1 - 0.12 12.0 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TFIIB PF00382.14 AIC14295.1 - 6.3e-09 35.5 0.7 1.9e-08 33.9 0.5 1.9 1 0 0 1 1 1 1 Transcription factor TFIIB repeat TrmB PF01978.14 AIC14295.1 - 3e-07 30.0 2.0 0.02 14.5 0.0 4.6 5 0 0 5 5 5 2 Sugar-specific transcriptional regulator TrmB DUF4423 PF14394.1 AIC14295.1 - 1.1e-05 25.0 0.7 0.14 11.6 0.0 3.3 2 1 1 3 3 3 2 Domain of unknown function (DUF4423) HTH_20 PF12840.2 AIC14295.1 - 7.5e-05 22.4 0.0 0.25 11.1 0.0 4.0 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_11 PF08279.7 AIC14295.1 - 0.001 18.6 0.7 0.072 12.7 0.1 3.0 3 0 0 3 3 2 1 HTH domain HTH_36 PF13730.1 AIC14295.1 - 0.0016 18.4 0.0 0.0091 16.1 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_27 PF13463.1 AIC14295.1 - 0.0023 18.2 0.2 4.6 7.6 0.0 4.0 4 0 0 4 4 4 1 Winged helix DNA-binding domain HTH_24 PF13412.1 AIC14295.1 - 0.0024 17.1 3.6 0.025 13.9 0.1 3.7 4 0 0 4 4 4 1 Winged helix-turn-helix DNA-binding Penicillinase_R PF03965.11 AIC14295.1 - 0.0052 16.8 0.6 0.42 10.7 0.0 3.0 3 0 0 3 3 2 1 Penicillinase repressor HTH_IclR PF09339.5 AIC14295.1 - 0.0081 15.7 0.1 0.075 12.6 0.0 2.6 2 0 0 2 2 2 1 IclR helix-turn-helix domain NTP_transf_5 PF14907.1 AIC14295.1 - 0.009 15.3 1.7 0.034 13.4 0.2 2.4 2 1 0 2 2 2 1 Uncharacterised nucleotidyltransferase Terminase_4 PF05119.7 AIC14295.1 - 0.013 15.6 0.6 0.18 12.0 0.0 2.9 3 0 0 3 3 3 0 Phage terminase, small subunit HTH_45 PF14947.1 AIC14295.1 - 0.022 14.5 0.5 30 4.5 0.0 3.6 3 0 0 3 3 3 0 Winged helix-turn-helix HTH_29 PF13551.1 AIC14295.1 - 0.022 14.8 0.4 1 9.5 0.0 3.3 4 0 0 4 4 3 0 Winged helix-turn helix HTH_41 PF14502.1 AIC14295.1 - 0.032 13.8 1.1 0.052 13.1 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain PaaX PF07848.7 AIC14295.1 - 0.032 14.2 0.3 0.19 11.7 0.0 2.4 2 0 0 2 2 2 0 PaaX-like protein HTH_Crp_2 PF13545.1 AIC14295.1 - 0.074 12.8 0.1 4.7 7.0 0.1 2.7 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_43 PF09904.4 AIC14295.1 - 0.076 12.8 0.0 0.76 9.6 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn helix HTH_12 PF08461.5 AIC14295.1 - 0.12 12.1 1.0 0.73 9.5 0.1 2.6 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain DUF2250 PF10007.4 AIC14295.1 - 4.2 7.3 7.1 2.4 8.1 0.0 3.7 4 0 0 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2250) HEAT_2 PF13646.1 AIC14296.1 - 3.8e-13 49.5 1.9 2.7e-06 27.5 0.0 2.8 1 1 2 3 3 3 3 HEAT repeats HEAT_PBS PF03130.11 AIC14296.1 - 2.4e-05 24.3 0.2 3.6 8.3 0.0 5.6 6 0 0 6 6 6 1 PBS lyase HEAT-like repeat Stn1_C PF12659.2 AIC14296.1 - 0.055 13.2 0.1 2.9 7.7 0.0 2.9 2 1 0 3 3 3 0 Telomere capping C-terminal wHTH YcbB PF08664.5 AIC14296.1 - 0.095 12.4 0.1 0.44 10.3 0.0 2.2 2 0 0 2 2 2 0 YcbB domain Ribosomal_L12 PF00542.14 AIC14296.1 - 0.11 12.5 0.7 3.6 7.6 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain TrbC PF04956.8 AIC14297.1 - 0.0053 16.7 3.1 0.0074 16.2 2.2 1.4 1 1 0 1 1 1 1 TrbC/VIRB2 family Xan_ur_permease PF00860.15 AIC14297.1 - 0.012 14.1 1.1 0.014 13.9 0.7 1.0 1 0 0 1 1 1 0 Permease family Yip1 PF04893.12 AIC14297.1 - 0.021 14.3 0.8 0.023 14.1 0.5 1.1 1 0 0 1 1 1 0 Yip1 domain TPPK_C PF12555.3 AIC14297.1 - 0.038 13.7 1.9 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal Herpes_glycop PF01528.11 AIC14297.1 - 0.08 11.6 2.4 0.096 11.3 1.6 1.0 1 0 0 1 1 1 0 Herpesvirus glycoprotein M DUF2207 PF09972.4 AIC14297.1 - 0.14 10.7 0.3 0.14 10.7 0.2 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4407 PF14362.1 AIC14297.1 - 0.14 11.0 1.2 0.16 10.9 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ExbD PF02472.11 AIC14297.1 - 0.31 11.0 2.4 0.44 10.5 1.7 1.2 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR Lipid_bd PF12888.2 AIC14298.1 - 0.054 13.3 0.3 0.11 12.3 0.1 1.6 1 1 0 1 1 1 0 Lipid-binding putative hydrolase Terminase_1 PF03354.10 AIC14301.1 - 0.067 11.5 0.1 0.077 11.3 0.0 1.1 1 0 0 1 1 1 0 Phage Terminase RHH_1 PF01402.16 AIC14302.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family Phage_integrase PF00589.17 AIC14303.1 - 0.00012 21.8 0.0 0.002 17.8 0.0 2.7 2 1 0 2 2 2 1 Phage integrase family HTH_38 PF13936.1 AIC14303.1 - 0.00015 21.2 0.4 0.00052 19.5 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain DNA_methylase PF00145.12 AIC14305.1 - 4.6e-62 210.0 0.0 3.9e-61 207.0 0.0 2.0 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase HhH-GPD PF00730.20 AIC14306.1 - 1.2e-13 51.3 0.0 1.7e-13 50.8 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 AIC14306.1 - 0.00024 20.6 0.2 0.00071 19.1 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.4 AIC14306.1 - 0.0027 17.8 5.2 0.0041 17.2 3.6 1.3 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III IFT20 PF14931.1 AIC14306.1 - 0.063 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 HHH_2 PF12826.2 AIC14306.1 - 0.15 11.9 0.0 8.2 6.3 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif Helicase_C PF00271.26 AIC14309.1 - 3.2e-10 39.7 0.0 7.8e-10 38.4 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AIC14309.1 - 1.9e-08 33.9 0.2 3.7e-05 23.2 0.0 3.5 4 0 0 4 4 4 2 DEAD/DEAH box helicase zf-ribbon_3 PF13248.1 AIC14309.1 - 3 7.1 8.3 0.72 9.1 2.8 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DZR PF12773.2 AIC14309.1 - 3.1 7.6 10.3 2.6e+02 1.5 7.1 2.4 1 1 0 1 1 1 0 Double zinc ribbon DUF1998 PF09369.5 AIC14310.1 - 4.5e-08 33.5 1.0 1.4e-07 31.9 0.7 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Zn-ribbon_8 PF09723.5 AIC14310.1 - 0.003 17.4 8.1 0.054 13.4 0.2 3.9 3 1 1 4 4 4 2 Zinc ribbon domain Ribosomal_L37ae PF01780.14 AIC14310.1 - 0.099 12.5 3.4 0.14 12.0 0.4 2.4 2 0 0 2 2 2 0 Ribosomal L37ae protein family zf-ribbon_3 PF13248.1 AIC14310.1 - 1 8.6 7.1 0.22 10.7 0.8 2.7 3 0 0 3 3 3 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 AIC14310.1 - 9.4 5.9 13.2 0.13 11.8 0.8 3.2 2 1 1 3 3 3 0 Putative transposase DNA-binding domain PLDc_2 PF13091.1 AIC14311.1 - 9.6e-09 35.0 0.0 1.6e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 PLD-like domain Response_reg PF00072.19 AIC14313.1 - 1.2e-23 83.2 0.4 1.8e-22 79.4 0.1 2.3 2 0 0 2 2 2 1 Response regulator receiver domain UPF0180 PF03698.8 AIC14313.1 - 0.01 15.6 0.1 1.9 8.3 0.0 3.2 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0180) Nucleocap_ssRNA PF11128.3 AIC14313.1 - 0.017 14.5 0.1 0.54 9.7 0.1 2.5 2 1 1 3 3 3 0 Plant viral coat protein nucleocapsid HGTP_anticodon PF03129.15 AIC14313.1 - 0.095 12.6 0.1 0.42 10.5 0.0 2.1 3 0 0 3 3 3 0 Anticodon binding domain Thy1 PF02511.10 AIC14314.1 - 1.5e-31 109.2 0.0 4.3e-19 68.6 1.0 2.5 2 1 0 2 2 2 2 Thymidylate synthase complementing protein DUF3247 PF11607.3 AIC14315.1 - 0.0095 16.1 0.2 0.19 11.9 0.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3247) DivIVA PF05103.8 AIC14315.1 - 0.078 13.0 3.0 0.15 12.1 2.1 1.5 1 1 0 1 1 1 0 DivIVA protein DASH_Dad1 PF08649.5 AIC14315.1 - 0.08 12.6 0.0 0.21 11.2 0.0 1.7 1 0 0 1 1 1 0 DASH complex subunit Dad1 IFT20 PF14931.1 AIC14315.1 - 0.18 11.7 1.9 1.4 8.8 0.4 2.3 1 1 2 3 3 3 0 Intraflagellar transport complex B, subunit 20 ERp29 PF07749.7 AIC14315.1 - 0.33 11.6 1.7 3.1 8.4 0.1 2.6 1 1 1 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain Chlorosome_CsmC PF11098.3 AIC14315.1 - 8.5 6.0 6.4 42 3.8 0.1 2.9 1 1 1 3 3 3 0 Chlorosome envelope protein C PRC PF05239.11 AIC14316.1 - 0.0087 15.9 1.9 0.02 14.7 0.6 2.1 2 0 0 2 2 2 1 PRC-barrel domain DUF3275 PF11679.3 AIC14316.1 - 0.047 13.3 3.3 0.065 12.8 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) DUF724 PF05266.9 AIC14316.1 - 0.12 11.9 8.1 0.11 12.0 4.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) GvpG PF05120.7 AIC14316.1 - 0.57 10.0 4.2 2.5 7.9 0.5 3.0 1 1 2 3 3 3 0 Gas vesicle protein G COX1 PF00115.15 AIC14317.1 - 5e-146 486.8 57.3 6.3e-146 486.5 39.7 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF2214 PF09980.4 AIC14318.1 - 0.16 11.7 3.0 0.57 9.9 1.4 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2214) ATP-synt_8 PF00895.15 AIC14318.1 - 9.1 6.5 7.2 1.1 9.5 0.9 2.3 2 0 0 2 2 2 0 ATP synthase protein 8 Flavin_Reduct PF01613.13 AIC14319.1 - 8.4e-28 97.1 0.0 1.2e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain Aminotran_3 PF00202.16 AIC14320.1 - 8.7e-58 195.7 0.0 1.5e-57 195.0 0.0 1.3 1 1 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.16 AIC14320.1 - 0.093 11.8 0.0 0.5 9.4 0.0 1.9 1 1 0 1 1 1 0 Beta-eliminating lyase DUF4475 PF14753.1 AIC14321.1 - 0.11 11.9 2.2 0.13 11.7 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4475) Cyclotide PF03784.8 AIC14321.1 - 0.12 12.2 0.6 0.22 11.4 0.4 1.5 1 0 0 1 1 1 0 Cyclotide family DUF4199 PF13858.1 AIC14322.1 - 0.086 12.7 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) ResIII PF04851.10 AIC14324.1 - 2.3e-12 47.1 0.0 8.3e-12 45.3 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 AIC14324.1 - 1.7e-09 37.3 0.0 1.2e-08 34.6 0.0 2.3 2 1 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AIC14324.1 - 2.7e-08 33.5 0.0 5.8e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain AAA_30 PF13604.1 AIC14324.1 - 0.00051 19.6 0.3 1.8 8.1 0.1 3.5 3 1 0 3 3 3 2 AAA domain DUF2075 PF09848.4 AIC14324.1 - 0.003 16.5 0.0 0.016 14.2 0.0 2.0 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DUF367 PF04034.8 AIC14325.1 - 5.2e-39 132.7 0.0 6.3e-39 132.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF367) RLI PF04068.10 AIC14325.1 - 0.012 15.2 0.1 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Possible Fer4-like domain in RNase L inhibitor, RLI FAINT PF04385.10 AIC14326.1 - 0.13 12.1 0.9 0.16 11.8 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function, DUF529 Inhibitor_I71 PF12628.2 AIC14326.1 - 0.13 11.8 0.9 0.16 11.5 0.6 1.0 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor DUF3574 PF12098.3 AIC14327.1 - 9.7e-05 21.8 0.0 0.0001 21.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3574) TraC PF07820.7 AIC14327.1 - 0.086 13.0 0.0 0.43 10.7 0.0 1.9 1 1 1 2 2 2 0 TraC-like protein Nol1_Nop2_Fmu PF01189.12 AIC14330.1 - 6e-65 219.4 0.0 6.9e-65 219.2 0.0 1.0 1 0 0 1 1 1 1 NOL1/NOP2/sun family Methyltransf_26 PF13659.1 AIC14330.1 - 3.1e-06 27.1 0.0 5.3e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14330.1 - 1.9e-05 25.1 0.1 3.2e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC14330.1 - 4.5e-05 23.0 0.0 6e-05 22.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.14 AIC14330.1 - 0.0016 18.4 0.0 0.0023 17.9 0.0 1.3 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.14 AIC14330.1 - 0.0024 17.4 0.0 0.0042 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.10 AIC14330.1 - 0.011 15.1 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 RrnaAD PF00398.15 AIC14330.1 - 0.013 14.5 0.0 0.019 14.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase POR PF01558.13 AIC14330.1 - 0.029 14.2 0.0 0.055 13.3 0.0 1.5 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase MTS PF05175.9 AIC14330.1 - 0.034 13.5 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_15 PF09445.5 AIC14330.1 - 0.078 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Fibrillarin PF01269.12 AIC14330.1 - 0.081 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin IL17 PF06083.6 AIC14330.1 - 0.11 12.5 0.0 11 6.1 0.0 2.3 2 0 0 2 2 2 0 Interleukin-17 UPF0113 PF03657.8 AIC14331.1 - 1.6e-23 83.1 0.0 1.9e-23 82.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0113) PUA PF01472.15 AIC14331.1 - 1.6e-08 34.1 0.2 3.7e-08 32.9 0.2 1.5 1 0 0 1 1 1 1 PUA domain HTH_7 PF02796.10 AIC14332.1 - 0.00053 19.7 0.0 0.00084 19.1 0.0 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_38 PF13936.1 AIC14332.1 - 0.017 14.6 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_39 PF14090.1 AIC14332.1 - 0.052 13.0 0.0 0.057 12.8 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain DUF433 PF04255.9 AIC14332.1 - 0.076 12.4 0.0 0.096 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF433) HTH_23 PF13384.1 AIC14332.1 - 0.08 12.6 0.0 0.091 12.4 0.0 1.1 1 0 0 1 1 1 0 Homeodomain-like domain Recombinase PF07508.8 AIC14332.1 - 0.12 12.6 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Recombinase UPF0052 PF01933.13 AIC14334.1 - 1.1e-49 169.3 0.1 1.5e-49 168.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 DUF374 PF04028.8 AIC14334.1 - 0.019 14.1 0.2 7 5.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF374) CofC PF01983.11 AIC14335.1 - 3.7e-25 88.1 0.0 4.6e-25 87.8 0.0 1.0 1 0 0 1 1 1 1 Guanylyl transferase CofC like NTP_transf_3 PF12804.2 AIC14335.1 - 1.6e-06 28.3 0.4 1.8e-06 28.1 0.3 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF2064 PF09837.4 AIC14335.1 - 0.031 13.8 0.6 0.047 13.3 0.1 1.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2064) Pox_RNA_Pol_22 PF05273.8 AIC14336.1 - 0.062 12.9 0.0 0.072 12.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus RNA polymerase 22 kDa subunit Mrr_cat PF04471.7 AIC14337.1 - 5.5e-05 22.9 0.0 9.3e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Restriction endonuclease DUF2070 PF09843.4 AIC14338.1 - 7e-30 103.8 0.2 1.1e-29 103.2 0.2 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) Sec61_beta PF03911.11 AIC14339.1 - 6.7e-13 48.2 0.6 7.6e-13 48.0 0.4 1.1 1 0 0 1 1 1 1 Sec61beta family Auto_anti-p27 PF06677.7 AIC14340.1 - 1.3e-07 31.1 0.6 2.4e-07 30.3 0.4 1.4 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) FbpA PF05833.6 AIC14340.1 - 0.035 12.6 0.4 0.04 12.4 0.3 1.0 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) DZR PF12773.2 AIC14340.1 - 0.075 12.8 1.1 0.17 11.7 0.8 1.6 1 0 0 1 1 1 0 Double zinc ribbon OrfB_Zn_ribbon PF07282.6 AIC14340.1 - 0.076 12.6 0.6 0.13 11.9 0.4 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Lar_restr_allev PF14354.1 AIC14340.1 - 0.34 11.2 4.0 1.1 9.6 2.8 1.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar zinc_ribbon_2 PF13240.1 AIC14340.1 - 0.57 9.7 5.4 5.6 6.5 3.9 2.2 1 1 2 3 3 3 0 zinc-ribbon domain DUF2387 PF09526.5 AIC14340.1 - 2.4 8.1 5.9 2.1 8.3 2.3 2.2 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) zf-ribbon_3 PF13248.1 AIC14340.1 - 3.5 6.9 6.3 15 4.9 0.3 2.2 1 1 1 2 2 2 0 zinc-ribbon domain SUI1 PF01253.17 AIC14341.1 - 9.8e-23 79.7 0.1 1.2e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 CHASE PF03924.8 AIC14342.1 - 6.5e-62 208.1 0.7 1.4e-61 207.1 0.5 1.5 1 0 0 1 1 1 1 CHASE domain HATPase_c PF02518.21 AIC14342.1 - 7.3e-30 102.9 0.0 1.8e-29 101.6 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 AIC14342.1 - 7.6e-13 48.2 0.0 7.6e-12 45.0 0.0 2.5 2 1 1 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.1 AIC14342.1 - 1.5e-06 27.9 0.1 3.3e-06 26.7 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.20 AIC14342.1 - 1.7e-05 24.9 0.8 1.7e-05 24.9 0.6 2.6 3 0 0 3 3 3 1 HAMP domain IncA PF04156.9 AIC14342.1 - 0.041 13.4 0.0 0.085 12.4 0.0 1.4 1 0 0 1 1 1 0 IncA protein Bul1_C PF04426.7 AIC14342.1 - 0.046 12.9 0.0 2.8 7.0 0.0 2.3 1 1 1 2 2 2 0 Bul1 C terminus TFIIB PF00382.14 AIC14344.1 - 3.9e-37 125.8 7.1 3.4e-18 65.2 0.4 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 AIC14344.1 - 1.1e-13 50.2 1.5 1.9e-13 49.5 1.1 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.1 AIC14344.1 - 0.00018 20.5 2.5 0.00037 19.5 1.8 1.5 1 0 0 1 1 1 1 zinc-ribbon domain Sigma70_r4 PF04545.11 AIC14344.1 - 0.00021 20.5 0.0 0.011 15.0 0.0 2.6 2 0 0 2 2 2 1 Sigma-70, region 4 Cyclin_N PF00134.18 AIC14344.1 - 0.00071 19.1 0.1 0.022 14.2 0.0 2.1 2 0 0 2 2 2 1 Cyclin, N-terminal domain Cyclin_C PF02984.14 AIC14344.1 - 0.002 18.0 0.1 1 9.2 0.0 2.4 2 1 0 2 2 2 2 Cyclin, C-terminal domain HTH_AsnC-type PF13404.1 AIC14344.1 - 0.0053 16.2 0.0 0.33 10.5 0.0 2.9 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain DZR PF12773.2 AIC14344.1 - 0.014 15.1 0.4 0.03 14.1 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon HTH_3 PF01381.17 AIC14344.1 - 0.024 14.4 0.0 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix LacI PF00356.16 AIC14344.1 - 0.031 13.8 3.0 0.56 9.8 0.1 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family zinc_ribbon_2 PF13240.1 AIC14344.1 - 0.035 13.6 2.8 1.7 8.2 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain HTH_23 PF13384.1 AIC14344.1 - 0.038 13.6 0.0 0.7 9.6 0.0 2.7 2 0 0 2 2 2 0 Homeodomain-like domain HTH_11 PF08279.7 AIC14344.1 - 0.063 12.9 0.1 5.1 6.8 0.0 2.6 2 0 0 2 2 2 0 HTH domain Sigma70_r4_2 PF08281.7 AIC14344.1 - 0.066 12.6 0.2 0.35 10.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 Rrf2 PF02082.15 AIC14344.1 - 0.074 13.1 0.4 24 5.1 0.0 3.1 3 0 0 3 3 3 0 Transcriptional regulator Lar_restr_allev PF14354.1 AIC14344.1 - 0.076 13.3 0.6 0.23 11.7 0.4 1.8 1 0 0 1 1 1 0 Restriction alleviation protein Lar Ribosomal_S27e PF01667.12 AIC14344.1 - 0.099 12.2 0.8 0.19 11.2 0.1 1.7 2 0 0 2 2 2 0 Ribosomal protein S27 MerR PF00376.18 AIC14344.1 - 0.15 11.6 0.1 1.6 8.3 0.0 2.5 2 0 0 2 2 2 0 MerR family regulatory protein OrfB_Zn_ribbon PF07282.6 AIC14344.1 - 0.26 10.9 1.3 0.62 9.7 0.9 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-CCHC_5 PF14787.1 AIC14344.1 - 0.98 8.9 3.9 3 7.4 2.4 2.0 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger Rib_5-P_isom_A PF06026.9 AIC14347.1 - 3e-50 169.8 0.0 3.9e-50 169.5 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.17 AIC14347.1 - 2.7e-06 27.0 0.0 0.0086 15.7 0.0 2.2 2 0 0 2 2 2 2 DeoR C terminal sensor domain Sugar-bind PF04198.8 AIC14347.1 - 0.007 15.2 0.0 0.012 14.5 0.0 1.3 1 0 0 1 1 1 1 Putative sugar-binding domain MscL PF01741.13 AIC14348.1 - 1e-20 74.1 4.4 1.2e-20 73.9 3.0 1.0 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL FtsX PF02687.16 AIC14348.1 - 0.0073 16.0 3.5 0.0093 15.7 2.4 1.2 1 0 0 1 1 1 1 FtsX-like permease family NPCC PF08058.6 AIC14348.1 - 0.13 12.0 0.2 0.17 11.7 0.1 1.2 1 0 0 1 1 1 0 Nuclear pore complex component Colicin_V PF02674.11 AIC14348.1 - 0.36 10.6 7.0 0.8 9.5 4.7 1.6 1 1 0 1 1 1 0 Colicin V production protein Amidohydro_4 PF13147.1 AIC14349.1 - 3.7e-29 102.6 0.4 5.4e-29 102.0 0.3 1.2 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_5 PF13594.1 AIC14349.1 - 6.1e-14 51.5 0.1 1.5e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Amidohydrolase Amidohydro_1 PF01979.15 AIC14349.1 - 4.4e-11 43.0 0.1 5.2e-07 29.6 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.6 AIC14349.1 - 7.1e-07 28.7 0.4 0.011 14.9 0.0 2.1 2 0 0 2 2 2 2 Amidohydrolase family Urease_alpha PF00449.15 AIC14349.1 - 0.00036 20.6 0.1 0.00094 19.3 0.1 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Nup188 PF10487.4 AIC14353.1 - 0.041 11.8 0.0 0.046 11.6 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 Imm27 PF15573.1 AIC14353.1 - 0.097 11.8 0.0 0.12 11.5 0.0 1.0 1 0 0 1 1 1 0 Immunity protein 27 SPT16 PF08644.6 AIC14353.1 - 0.25 11.1 2.2 0.27 11.0 1.5 1.1 1 0 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) DUF3291 PF11695.3 AIC14355.1 - 3.8e-06 26.3 1.1 6.7e-06 25.5 0.7 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3291) DUF4188 PF13826.1 AIC14355.1 - 0.00029 20.9 0.2 0.00038 20.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) ABM PF03992.11 AIC14355.1 - 0.096 12.7 0.5 0.26 11.3 0.0 1.9 2 0 0 2 2 2 0 Antibiotic biosynthesis monooxygenase ErmC PF06308.6 AIC14355.1 - 0.35 10.9 2.6 0.78 9.8 1.8 1.6 1 1 0 1 1 1 0 23S rRNA methylase leader peptide (ErmC) Polysacc_deac_1 PF01522.16 AIC14356.1 - 1.2e-11 44.2 0.0 2e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 AIC14356.1 - 0.00021 20.3 0.0 0.00027 19.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 PAS_8 PF13188.1 AIC14356.1 - 0.14 12.0 0.0 5.3 7.0 0.0 2.9 2 1 1 3 3 3 0 PAS domain HTH_45 PF14947.1 AIC14357.1 - 6.2e-18 64.3 0.1 7.8e-18 64.0 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC14357.1 - 0.027 14.0 0.0 0.03 13.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) TIG PF01833.19 AIC14358.1 - 9.3e-05 22.3 21.1 0.0015 18.5 2.5 3.2 3 1 0 3 3 3 2 IPT/TIG domain A2M_N PF01835.14 AIC14358.1 - 0.014 15.6 0.1 5.2 7.3 0.0 2.4 2 0 0 2 2 2 0 MG2 domain BiPBP_C PF06832.7 AIC14358.1 - 0.058 13.3 0.4 4.1 7.3 0.0 3.3 3 1 0 3 3 3 0 Penicillin-Binding Protein C-terminus Family NPCBM_assoc PF10633.4 AIC14358.1 - 0.099 12.7 0.4 0.099 12.7 0.3 4.6 3 1 1 4 4 4 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Sod_Cu PF00080.15 AIC14358.1 - 0.16 12.1 2.1 0.15 12.1 0.3 1.8 2 0 0 2 2 2 0 Copper/zinc superoxide dismutase (SODC) CarboxypepD_reg PF13620.1 AIC14358.1 - 0.74 9.9 17.8 0.08 13.0 1.4 3.6 2 1 1 3 3 3 0 Carboxypeptidase regulatory-like domain DUF4112 PF13430.1 AIC14359.1 - 0.0089 15.9 0.7 1.3 9.0 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4112) DER1 PF04511.10 AIC14359.1 - 0.012 15.1 0.0 0.014 14.9 0.0 1.1 1 0 0 1 1 1 0 Der1-like family Dicistro_VP4 PF11492.3 AIC14359.1 - 0.033 14.2 0.7 1.5 8.8 0.1 2.3 1 1 1 2 2 2 0 Cricket paralysis virus, VP4 Patatin PF01734.17 AIC14361.1 - 8.5e-15 55.2 0.0 4.7e-14 52.8 0.0 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3734 PF12536.3 AIC14361.1 - 0.059 13.4 0.1 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 Patatin phospholipase Cupin_2 PF07883.6 AIC14362.1 - 1.6e-07 30.7 0.1 4.6e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.7 AIC14362.1 - 9.6e-07 28.1 0.0 2.3e-06 26.9 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF861) AraC_binding_2 PF14525.1 AIC14362.1 - 2.7e-05 23.7 0.0 3.4e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 AraC-binding-like domain AraC_binding PF02311.14 AIC14362.1 - 0.003 17.2 0.0 0.0049 16.5 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.2 AIC14362.1 - 0.0043 16.6 0.0 0.0051 16.4 0.0 1.1 1 0 0 1 1 1 1 Cupin Cupin_1 PF00190.17 AIC14362.1 - 0.026 13.9 0.0 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 Cupin DUF1014 PF06244.7 AIC14363.1 - 0.041 14.1 0.8 0.052 13.7 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1014) Glyco_hydro_25 PF01183.15 AIC14363.1 - 0.067 13.0 0.0 0.076 12.8 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 25 Syntaxin PF00804.20 AIC14363.1 - 0.12 12.6 2.2 0.17 12.0 1.5 1.5 1 1 0 1 1 1 0 Syntaxin zf-C2H2_2 PF12756.2 AIC14364.1 - 4.4e-06 26.7 0.5 5.5e-06 26.4 0.3 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 AIC14364.1 - 0.0011 19.1 0.1 0.0019 18.3 0.1 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AIC14364.1 - 0.021 14.9 0.5 0.039 14.0 0.3 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.21 AIC14364.1 - 0.048 14.0 0.1 0.089 13.1 0.1 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-met PF12874.2 AIC14364.1 - 0.05 13.8 0.2 0.085 13.0 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type MHC_I PF00129.13 AIC14365.1 - 0.041 13.2 0.4 0.048 13.0 0.3 1.0 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Malic_M PF03949.10 AIC14366.1 - 1.3e-59 201.8 0.2 1.7e-59 201.4 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.14 AIC14366.1 - 5.3e-21 75.0 3.5 2.9e-18 66.0 0.2 3.1 2 1 1 3 3 3 2 Malic enzyme, N-terminal domain ELFV_dehydrog PF00208.16 AIC14366.1 - 7.9e-06 25.6 2.2 0.00016 21.3 1.2 2.5 2 1 1 3 3 3 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase AdoHcyase_NAD PF00670.16 AIC14366.1 - 0.00049 19.9 1.7 0.032 14.0 0.0 3.0 3 0 0 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Shikimate_DH PF01488.15 AIC14366.1 - 0.0058 16.7 0.9 0.043 13.9 0.1 2.6 2 1 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.14 AIC14366.1 - 0.0064 15.5 0.1 0.0095 15.0 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 AIC14366.1 - 0.05 13.4 0.2 0.087 12.6 0.2 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.13 AIC14366.1 - 0.062 13.3 2.5 0.13 12.2 0.1 2.6 3 1 0 3 3 3 0 TrkA-N domain 3HCDH_N PF02737.13 AIC14366.1 - 0.091 12.4 1.0 0.14 11.7 0.2 1.7 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 AIC14366.1 - 0.093 11.8 0.4 0.23 10.5 0.1 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ThiF PF00899.16 AIC14366.1 - 0.13 12.0 1.8 0.19 11.5 0.2 2.1 2 0 0 2 2 2 0 ThiF family AlaDh_PNT_C PF01262.16 AIC14366.1 - 0.15 11.6 1.1 0.75 9.3 0.3 2.4 2 1 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain zf-C2H2_6 PF13912.1 AIC14367.1 - 5.3e-05 22.9 7.9 0.0007 19.4 0.5 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_4 PF13894.1 AIC14367.1 - 5.6e-05 23.1 13.9 0.0005 20.1 0.2 2.8 3 0 0 3 3 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC14367.1 - 0.00015 21.8 10.0 0.0054 16.9 0.3 3.3 4 0 0 4 4 3 2 Zinc finger, C2H2 type zinc_ribbon_5 PF13719.1 AIC14367.1 - 0.0058 16.1 3.4 0.059 12.9 2.4 2.1 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC14367.1 - 0.012 15.3 3.7 0.12 12.1 2.6 2.1 1 1 0 1 1 1 0 zinc-ribbon domain LIM PF00412.17 AIC14367.1 - 0.018 15.1 5.0 0.025 14.6 3.3 1.5 1 1 0 1 1 1 0 LIM domain zf-trcl PF13451.1 AIC14367.1 - 0.024 14.2 4.9 0.13 11.9 0.1 2.3 2 0 0 2 2 2 0 Probable zinc-binding domain Lar_restr_allev PF14354.1 AIC14367.1 - 0.035 14.4 1.9 0.072 13.4 1.3 1.5 1 1 0 1 1 1 0 Restriction alleviation protein Lar DZR PF12773.2 AIC14367.1 - 0.051 13.4 0.8 0.1 12.4 0.5 1.5 1 1 0 1 1 1 0 Double zinc ribbon DUF2321 PF10083.4 AIC14367.1 - 0.065 12.7 0.1 0.081 12.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) Elf1 PF05129.8 AIC14367.1 - 0.072 12.7 3.3 0.078 12.6 1.5 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like DUF866 PF05907.8 AIC14367.1 - 0.072 12.5 1.1 0.087 12.3 0.7 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) DUF1178 PF06676.6 AIC14367.1 - 0.083 13.0 2.1 0.094 12.9 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1178) XPA_N PF01286.13 AIC14367.1 - 0.088 12.4 3.9 1.2 8.8 0.1 2.3 2 0 0 2 2 2 0 XPA protein N-terminal Prok-RING_1 PF14446.1 AIC14367.1 - 0.094 12.4 5.6 3.7 7.3 0.4 2.4 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-DNA_Pol PF08996.5 AIC14367.1 - 0.095 12.0 1.7 0.094 12.0 0.5 1.4 1 1 1 2 2 2 0 DNA Polymerase alpha zinc finger zf-RING_3 PF14369.1 AIC14367.1 - 0.18 11.8 2.7 0.37 10.8 0.2 2.2 2 0 0 2 2 2 0 zinc-finger DNA_RNApol_7kD PF03604.8 AIC14367.1 - 0.18 11.2 2.0 0.59 9.6 0.1 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit UPF0547 PF10571.4 AIC14367.1 - 0.18 11.4 3.7 0.75 9.5 2.5 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 HypA PF01155.14 AIC14367.1 - 0.37 10.5 2.6 2.3 7.9 0.2 1.9 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 AIC14367.1 - 0.49 10.3 8.3 7.7 6.5 0.8 2.4 1 1 1 2 2 2 0 Zinc ribbon domain DUF629 PF04780.7 AIC14367.1 - 0.5 8.8 11.7 0.22 10.0 2.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Terminase_GpA PF05876.7 AIC14367.1 - 0.69 8.2 3.8 0.71 8.1 2.6 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) zf-HYPF PF07503.7 AIC14367.1 - 1.2 8.6 6.7 2.7 7.4 1.0 2.3 2 0 0 2 2 2 0 HypF finger CpXC PF14353.1 AIC14367.1 - 1.2 9.0 5.4 3.6 7.5 3.8 1.8 1 1 0 1 1 1 0 CpXC protein zf-LYAR PF08790.6 AIC14367.1 - 1.4 8.6 6.4 8.4 6.1 0.5 2.8 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger FYVE PF01363.16 AIC14367.1 - 2.1 8.3 7.7 5.7 6.9 2.0 2.1 1 1 1 2 2 2 0 FYVE zinc finger HNH PF01844.18 AIC14367.1 - 4.9 7.1 14.5 1.3 8.9 3.0 2.4 2 0 0 2 2 2 0 HNH endonuclease DNA_Packaging PF11053.3 AIC14368.1 - 0.16 11.5 2.6 0.15 11.6 0.6 1.8 1 1 1 2 2 2 0 Terminase DNA packaging enzyme DUF21 PF01595.15 AIC14368.1 - 0.2 10.9 3.1 0.4 9.9 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF21 DUF2786 PF10979.3 AIC14368.1 - 0.34 10.6 2.2 4.6 7.0 0.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2786) HTH_45 PF14947.1 AIC14369.1 - 2.6e-10 39.9 0.1 3.4e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_27 PF13463.1 AIC14369.1 - 0.00011 22.4 0.1 0.00015 21.9 0.1 1.1 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.1 AIC14369.1 - 0.015 14.7 0.5 0.03 13.7 0.3 1.5 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF4364 PF14277.1 AIC14369.1 - 0.017 14.7 0.0 0.02 14.5 0.0 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4364) FAD_binding_4 PF01565.18 AIC14369.1 - 0.025 14.0 0.0 0.031 13.7 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain HTH_20 PF12840.2 AIC14369.1 - 0.07 12.9 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain FaeA PF04703.7 AIC14369.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 FaeA-like protein DUF2250 PF10007.4 AIC14369.1 - 0.14 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) Yip1 PF04893.12 AIC14370.1 - 0.058 12.8 0.6 0.069 12.6 0.4 1.1 1 0 0 1 1 1 0 Yip1 domain DUF1469 PF07332.6 AIC14370.1 - 4.6 7.0 6.2 10 5.8 4.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1469) Gram_pos_anchor PF00746.16 AIC14370.1 - 7.8 6.4 7.4 0.91 9.4 1.3 2.0 2 0 0 2 2 2 0 Gram positive anchor Peptidase_M50B PF13398.1 AIC14372.1 - 0.0029 17.0 7.4 0.0042 16.5 5.1 1.3 1 0 0 1 1 1 1 Peptidase M50B-like Peptidase_M50 PF02163.17 AIC14372.1 - 0.18 10.7 0.9 0.23 10.4 0.6 1.5 1 1 0 1 1 1 0 Peptidase family M50 Zip PF02535.17 AIC14373.1 - 2.2e-08 33.4 16.6 3.9e-07 29.3 2.9 2.1 2 0 0 2 2 2 2 ZIP Zinc transporter AzlD PF05437.7 AIC14373.1 - 4.3 7.3 15.9 0.088 12.7 2.3 3.0 3 1 0 3 3 3 0 Branched-chain amino acid transport protein (AzlD) dCMP_cyt_deam_1 PF00383.17 AIC14374.1 - 9.2e-07 28.4 0.1 2.9e-06 26.8 0.1 1.7 2 0 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region O-antigen_lig PF13425.1 AIC14375.1 - 0.13 12.2 0.2 0.21 11.5 0.1 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein FAP PF07174.6 AIC14375.1 - 0.52 9.5 5.1 0.77 8.9 3.6 1.3 1 1 0 1 1 1 0 Fibronectin-attachment protein (FAP) Acetyltransf_1 PF00583.19 AIC14379.1 - 3.8e-10 39.6 0.7 6e-09 35.8 0.2 2.4 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AIC14379.1 - 1e-08 35.2 0.1 4.2e-08 33.2 0.1 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AIC14379.1 - 0.00057 19.7 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 AIC14379.1 - 0.00057 19.5 0.1 0.0018 17.9 0.1 1.8 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_10 PF13673.1 AIC14379.1 - 0.0019 18.3 0.0 0.0038 17.3 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 AIC14379.1 - 0.018 15.1 0.0 0.098 12.8 0.0 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Pribosyltran PF00156.22 AIC14380.1 - 3e-14 52.8 0.4 6.1e-14 51.8 0.3 1.4 1 1 0 1 1 1 1 Phosphoribosyl transferase domain Zn_Tnp_IS1595 PF12760.2 AIC14381.1 - 0.00086 19.0 1.7 0.00097 18.8 1.1 1.1 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC14381.1 - 0.0014 18.2 3.5 0.0033 16.9 2.4 1.5 1 1 0 1 1 1 1 zinc-ribbon domain DUF2387 PF09526.5 AIC14381.1 - 0.0018 18.1 0.4 0.0022 17.8 0.3 1.1 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) zinc_ribbon_4 PF13717.1 AIC14381.1 - 0.0041 16.7 4.2 0.014 15.0 2.9 1.7 1 1 0 1 1 1 1 zinc-ribbon domain UPF0515 PF15135.1 AIC14381.1 - 0.0086 15.1 1.3 0.0087 15.1 0.9 1.0 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 Zn_Tnp_IS1 PF03811.8 AIC14381.1 - 0.015 14.8 2.5 0.032 13.7 1.7 1.6 1 1 0 1 1 1 0 InsA N-terminal domain FANCL_C PF11793.3 AIC14381.1 - 0.034 14.1 0.6 0.93 9.4 0.0 2.0 2 0 0 2 2 2 0 FANCL C-terminal domain OrfB_Zn_ribbon PF07282.6 AIC14381.1 - 0.088 12.4 1.0 0.12 12.0 0.7 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Prim_Zn_Ribbon PF08273.7 AIC14381.1 - 0.1 12.6 0.6 0.12 12.4 0.4 1.1 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase zf-rbx1 PF12678.2 AIC14381.1 - 0.12 12.5 0.2 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 RING-H2 zinc finger zf-Apc11 PF12861.2 AIC14381.1 - 0.12 12.1 1.8 0.28 11.0 1.3 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.1 AIC14381.1 - 0.15 11.9 0.9 2.7 7.9 0.0 2.0 2 0 0 2 2 2 0 Ring finger domain Zn-ribbon_8 PF09723.5 AIC14381.1 - 0.21 11.5 3.0 9.4 6.2 0.0 2.1 2 0 0 2 2 2 0 Zinc ribbon domain zf-RING_4 PF14570.1 AIC14381.1 - 0.21 11.2 2.6 1.5 8.5 0.3 2.1 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-Mss51 PF13824.1 AIC14381.1 - 0.23 11.3 1.1 0.3 10.9 0.8 1.1 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 DUF3797 PF12677.2 AIC14381.1 - 0.32 10.6 2.4 0.39 10.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) DUF4182 PF13790.1 AIC14381.1 - 0.37 10.6 2.6 0.58 9.9 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4182) DnaJ_CXXCXGXG PF00684.14 AIC14381.1 - 0.41 10.7 3.9 1.1 9.3 2.7 1.6 1 1 0 1 1 1 0 DnaJ central domain C1_4 PF07975.7 AIC14381.1 - 0.51 10.3 4.4 5.5 7.0 3.0 2.0 1 1 0 1 1 1 0 TFIIH C1-like domain zf-RING_5 PF14634.1 AIC14381.1 - 1 9.1 4.8 6 6.6 3.7 1.8 1 1 1 2 2 2 0 zinc-RING finger domain zf-H2C2_2 PF13465.1 AIC14381.1 - 1 9.7 5.4 9.3 6.7 0.4 2.1 2 0 0 2 2 2 0 Zinc-finger double domain zf-TFIIB PF13453.1 AIC14381.1 - 1 8.5 3.3 1.7 7.9 2.3 1.3 1 1 0 1 1 1 0 Transcription factor zinc-finger zf-C4_Topoisom PF01396.14 AIC14381.1 - 1.1 8.8 7.0 0.36 10.3 2.4 1.9 1 1 1 2 2 2 0 Topoisomerase DNA binding C4 zinc finger PhnA_Zn_Ribbon PF08274.7 AIC14381.1 - 1.2 9.0 3.9 3.1 7.6 2.7 1.7 1 1 0 1 1 1 0 PhnA Zinc-Ribbon DUF2296 PF10058.4 AIC14381.1 - 1.2 8.9 3.9 3.5 7.4 0.2 2.0 1 1 1 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Rubredoxin PF00301.15 AIC14381.1 - 1.3 8.9 4.3 9.7 6.1 0.4 2.2 2 0 0 2 2 2 0 Rubredoxin zf-MYND PF01753.13 AIC14381.1 - 1.3 8.9 5.3 7.2 6.5 3.7 1.9 1 1 0 1 1 1 0 MYND finger zf-HIT PF04438.11 AIC14381.1 - 1.5 8.5 5.7 4.6 6.9 0.6 2.1 2 0 0 2 2 2 0 HIT zinc finger TFIIS_C PF01096.13 AIC14381.1 - 1.6 8.4 7.8 4.2 7.0 0.5 2.1 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS) zf-C2H2_4 PF13894.1 AIC14381.1 - 1.7 9.1 4.1 29 5.3 0.9 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AIC14381.1 - 3.7 7.5 6.2 1.4 8.9 0.4 2.1 2 0 0 2 2 2 0 C2H2-type zinc finger MIase PF02426.11 AIC14384.1 - 2.9e-06 26.9 0.0 7.5e-06 25.6 0.0 1.7 1 1 1 2 2 2 1 Muconolactone delta-isomerase Hemerythrin PF01814.18 AIC14385.1 - 1.5e-13 51.0 0.1 3e-13 50.0 0.0 1.5 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain GFA PF04828.9 AIC14386.1 - 0.0027 17.6 0.0 2.4 8.1 0.0 2.1 2 0 0 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme Yippee-Mis18 PF03226.9 AIC14386.1 - 0.012 15.6 0.0 6.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF4451 PF14616.1 AIC14386.1 - 0.046 13.4 0.3 0.082 12.6 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4451) Arc_trans_TRASH PF08394.5 AIC14386.1 - 0.057 13.5 1.1 0.98 9.6 0.0 2.8 3 0 0 3 3 3 0 Archaeal TRASH domain PRP1_N PF06424.7 AIC14386.1 - 0.098 12.9 0.1 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal PDZ_2 PF13180.1 AIC14387.1 - 3.9e-14 52.3 0.3 1.2e-11 44.3 0.2 2.3 1 1 0 1 1 1 1 PDZ domain PDZ PF00595.19 AIC14387.1 - 1.6e-10 41.0 0.2 1.6e-05 24.9 0.0 2.2 2 0 0 2 2 2 2 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 AIC14387.1 - 0.0058 16.3 0.2 0.2 11.4 0.0 2.2 1 1 1 2 2 2 1 Tricorn protease PDZ domain Aminotran_3 PF00202.16 AIC14388.1 - 2.5e-73 246.8 0.0 3.1e-73 246.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III PrpR_N PF06506.6 AIC14388.1 - 0.12 11.7 0.0 0.4 10.0 0.0 1.8 2 0 0 2 2 2 0 Propionate catabolism activator Acyl-CoA_dh_1 PF00441.19 AIC14389.1 - 2.3e-33 115.4 3.6 4.2e-32 111.3 2.5 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.11 AIC14389.1 - 3.3e-19 69.5 0.4 1e-18 67.9 0.0 2.0 2 1 1 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.14 AIC14389.1 - 2.2e-15 55.8 0.1 3.9e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.6 AIC14389.1 - 2.4e-12 47.2 8.6 1e-11 45.1 6.0 1.9 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain MaoC_dehydratas PF01575.14 AIC14390.1 - 0.00014 21.2 0.0 0.0013 18.1 0.0 2.0 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.1 AIC14390.1 - 0.0058 16.4 0.0 0.0091 15.7 0.0 1.5 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase HMD PF03201.11 AIC14391.1 - 0.2 11.6 9.4 0.19 11.6 6.2 1.3 1 1 0 1 1 1 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase Peptidase_C11 PF03415.9 AIC14391.1 - 0.44 9.4 4.7 0.48 9.3 3.3 1.0 1 0 0 1 1 1 0 Clostripain family DUF2922 PF11148.3 AIC14392.1 - 0.062 12.9 1.8 3 7.5 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2922) Ead_Ea22 PF13935.1 AIC14392.1 - 0.096 13.0 3.1 0.12 12.7 2.1 1.2 1 0 0 1 1 1 0 Ead/Ea22-like protein DUF1183 PF06682.7 AIC14394.1 - 7.3 6.0 10.4 15 5.0 6.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1183) DUF480 PF04337.7 AIC14395.1 - 0.034 14.0 0.2 0.036 13.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF480 Gp-FAR-1 PF05823.7 AIC14395.1 - 0.046 13.6 1.0 0.05 13.5 0.7 1.0 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) PP1_inhibitor PF05361.7 AIC14395.1 - 0.084 12.5 2.2 0.13 11.9 1.5 1.3 1 1 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor Chordopox_G3 PF06129.7 AIC14396.1 - 0.02 15.0 1.0 0.05 13.7 0.5 1.8 2 0 0 2 2 2 0 Chordopoxvirus G3 protein DZR PF12773.2 AIC14397.1 - 0.002 17.8 1.4 0.0029 17.3 1.0 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF1272 PF06906.6 AIC14397.1 - 0.023 14.5 0.9 0.033 14.0 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-ribbon_3 PF13248.1 AIC14397.1 - 0.026 13.7 5.7 0.16 11.2 0.7 2.2 1 1 0 2 2 2 0 zinc-ribbon domain PolC_DP2 PF03833.8 AIC14397.1 - 0.12 9.9 0.4 0.13 9.8 0.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 SieB PF14163.1 AIC14397.1 - 0.14 11.7 0.4 0.19 11.3 0.3 1.3 1 0 0 1 1 1 0 Superinfection exclusion protein B zinc_ribbon_2 PF13240.1 AIC14397.1 - 0.17 11.3 5.8 1 8.9 0.5 2.2 1 1 2 3 3 3 0 zinc-ribbon domain DUF2296 PF10058.4 AIC14397.1 - 0.24 11.1 3.1 0.87 9.3 0.1 2.2 1 1 1 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) TFIIS_C PF01096.13 AIC14397.1 - 0.32 10.6 1.9 15 5.3 0.0 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DUF2628 PF10947.3 AIC14397.1 - 0.37 10.5 2.3 0.57 9.9 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2628) Zn-ribbon_8 PF09723.5 AIC14397.1 - 0.55 10.2 5.6 5.9 6.9 3.9 2.1 1 1 0 1 1 1 0 Zinc ribbon domain zinc_ribbon_5 PF13719.1 AIC14397.1 - 0.73 9.4 3.6 1.6 8.3 0.2 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-HIT PF04438.11 AIC14397.1 - 0.81 9.3 5.7 1.3 8.7 3.9 1.3 1 0 0 1 1 1 0 HIT zinc finger zf-ISL3 PF14690.1 AIC14397.1 - 0.87 9.6 5.0 0.38 10.8 0.4 2.3 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 OrfB_Zn_ribbon PF07282.6 AIC14397.1 - 0.96 9.1 3.7 7.2 6.3 0.3 2.2 1 1 1 2 2 2 0 Putative transposase DNA-binding domain RRN7 PF11781.3 AIC14397.1 - 1 8.8 4.8 2.5 7.6 1.2 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-NADH-PPase PF09297.6 AIC14397.1 - 1 8.8 4.1 1.5 8.3 0.5 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain TF_Zn_Ribbon PF08271.7 AIC14397.1 - 1.3 8.3 6.6 1.9 7.8 0.7 2.1 1 1 0 2 2 2 0 TFIIB zinc-binding DUF1610 PF07754.6 AIC14397.1 - 2.4 8.3 5.8 6.8 6.9 4.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1610) zf-HYPF PF07503.7 AIC14397.1 - 3.4 7.1 5.1 1.9 8.0 0.6 2.5 2 1 0 2 2 2 0 HypF finger C1_4 PF07975.7 AIC14398.1 - 0.0068 16.3 0.4 0.0077 16.2 0.3 1.1 1 0 0 1 1 1 1 TFIIH C1-like domain zf-met PF12874.2 AIC14398.1 - 0.054 13.7 0.6 0.1 12.8 0.4 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type IMS PF00817.15 AIC14399.1 - 2.3e-42 144.3 0.2 4.2e-42 143.4 0.1 1.5 1 0 0 1 1 1 1 impB/mucB/samB family DUF72 PF01904.13 AIC14399.1 - 2.5e-18 66.6 0.4 5.2e-18 65.6 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF72 IMS_C PF11799.3 AIC14399.1 - 2e-14 53.5 0.0 4.3e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.3 AIC14399.1 - 2.7e-07 30.2 0.1 5.4e-07 29.2 0.1 1.6 1 0 0 1 1 1 1 IMS family HHH motif HHH_5 PF14520.1 AIC14399.1 - 0.0002 21.4 0.1 0.00057 19.9 0.0 1.9 1 1 0 1 1 1 1 Helix-hairpin-helix domain Cdd1 PF11731.3 AIC14399.1 - 0.00071 19.4 0.0 0.0022 17.9 0.0 1.8 1 0 0 1 1 1 1 Pathogenicity locus DUF4332 PF14229.1 AIC14399.1 - 0.037 13.9 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Pro_isomerase PF00160.16 AIC14400.1 - 4.4e-52 176.4 0.1 4.9e-52 176.2 0.0 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD MCR_beta PF02241.13 AIC14400.1 - 0.096 11.8 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain TetR_N PF00440.18 AIC14401.1 - 1.6e-18 66.0 0.3 4.4e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.1 AIC14401.1 - 4e-11 42.9 0.0 7.3e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial transcriptional repressor DM13 PF10517.4 AIC14402.1 - 3.4e-27 94.9 0.0 5.7e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Electron transfer DM13 RVT_3 PF13456.1 AIC14403.1 - 1e-18 66.8 0.1 1.3e-18 66.4 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.19 AIC14403.1 - 4.4e-13 49.7 0.0 5.6e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 RNase H Bap31 PF05529.7 AIC14405.1 - 0.002 17.6 0.3 0.0021 17.5 0.2 1.1 1 0 0 1 1 1 1 B-cell receptor-associated protein 31-like DUF4140 PF13600.1 AIC14405.1 - 0.0037 17.7 0.3 0.0041 17.5 0.2 1.0 1 0 0 1 1 1 1 N-terminal domain of unknown function (DUF4140) DivIC PF04977.10 AIC14405.1 - 0.007 15.8 0.2 0.0078 15.6 0.1 1.1 1 0 0 1 1 1 1 Septum formation initiator Lebercilin PF15619.1 AIC14405.1 - 0.0089 15.4 2.9 0.01 15.2 2.0 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease GAS PF13851.1 AIC14405.1 - 0.015 14.5 1.5 0.016 14.4 1.1 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.1 AIC14405.1 - 0.019 14.9 3.0 0.024 14.6 2.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Cep57_MT_bd PF06657.8 AIC14405.1 - 0.02 14.8 2.0 0.023 14.6 1.4 1.1 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 TMF_DNA_bd PF12329.3 AIC14405.1 - 0.028 14.2 3.2 0.037 13.8 2.2 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding Macoilin PF09726.4 AIC14405.1 - 0.029 12.6 0.8 0.028 12.7 0.6 1.0 1 0 0 1 1 1 0 Transmembrane protein Seryl_tRNA_N PF02403.17 AIC14405.1 - 0.034 14.1 1.2 0.04 13.9 0.8 1.1 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4319 PF14203.1 AIC14405.1 - 0.047 13.2 0.8 0.058 12.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4319) CCDC-167 PF15188.1 AIC14405.1 - 0.05 13.5 0.7 0.05 13.5 0.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Tmemb_cc2 PF10267.4 AIC14405.1 - 0.067 11.7 1.8 0.079 11.5 1.2 1.0 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein TPD52 PF04201.10 AIC14405.1 - 0.12 12.0 1.0 0.13 11.9 0.7 1.0 1 0 0 1 1 1 0 Tumour protein D52 family Atg14 PF10186.4 AIC14405.1 - 0.13 11.2 2.5 0.14 11.1 1.7 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 FTA4 PF13093.1 AIC14405.1 - 0.14 11.6 0.8 0.15 11.4 0.5 1.0 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Med9 PF07544.8 AIC14405.1 - 0.23 11.2 2.0 0.3 10.8 1.4 1.2 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 DUF465 PF04325.8 AIC14405.1 - 0.69 9.6 8.0 2 8.2 4.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF465) SIMPL PF04402.9 AIC14406.1 - 8.9e-46 156.3 3.5 1.1e-45 156.0 2.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Mucin PF01456.12 AIC14406.1 - 0.052 13.3 5.4 0.13 12.0 3.7 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3597 PF12200.3 AIC14406.1 - 1.2 9.5 5.7 0.28 11.5 0.9 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3597) Beta_propel PF09826.4 AIC14407.1 - 6.4e-158 526.3 6.3 7.5e-158 526.1 4.4 1.0 1 0 0 1 1 1 1 Beta propeller domain Herpes_capsid PF06112.6 AIC14408.1 - 0.093 12.7 3.8 0.14 12.1 2.7 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Serglycin PF04360.7 AIC14408.1 - 0.16 11.6 2.3 0.35 10.5 1.6 1.5 1 0 0 1 1 1 0 Serglycin DUF2951 PF11166.3 AIC14409.1 - 0.0067 16.2 1.7 0.011 15.6 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2951) Poty_PP PF08440.5 AIC14409.1 - 0.019 14.0 3.0 0.024 13.7 2.1 1.1 1 0 0 1 1 1 0 Potyviridae polyprotein ATG16 PF08614.6 AIC14409.1 - 0.021 14.6 2.4 0.021 14.6 1.7 1.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CorA PF01544.13 AIC14409.1 - 0.026 13.5 0.2 0.04 12.9 0.1 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein BLOC1_2 PF10046.4 AIC14409.1 - 0.028 14.5 2.2 0.056 13.5 1.5 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.6 AIC14409.1 - 0.029 13.0 7.5 0.032 12.9 5.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6 PF04111.7 AIC14409.1 - 0.059 12.4 5.1 0.068 12.2 3.6 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 DUF4239 PF14023.1 AIC14409.1 - 0.18 11.1 0.8 0.21 10.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) CDC37_N PF03234.9 AIC14409.1 - 0.18 12.0 4.9 0.25 11.6 3.4 1.3 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding TPR_MLP1_2 PF07926.7 AIC14409.1 - 0.21 11.3 9.3 0.36 10.5 0.5 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FlxA PF14282.1 AIC14409.1 - 0.24 11.3 11.2 0.047 13.6 4.4 2.0 1 1 1 2 2 2 0 FlxA-like protein DUF3138 PF11336.3 AIC14409.1 - 0.26 9.4 3.9 0.34 9.0 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) CCDC155 PF14662.1 AIC14409.1 - 0.31 10.6 8.8 0.39 10.3 6.1 1.3 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 IncA PF04156.9 AIC14409.1 - 0.32 10.5 3.4 0.39 10.2 2.3 1.1 1 0 0 1 1 1 0 IncA protein TBCA PF02970.11 AIC14409.1 - 0.49 10.5 8.7 6.7 6.8 2.2 3.1 1 1 1 2 2 2 0 Tubulin binding cofactor A HeLo PF14479.1 AIC14409.1 - 0.54 9.9 4.6 0.67 9.6 3.2 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation GAS PF13851.1 AIC14409.1 - 0.65 9.1 11.0 0.44 9.7 5.6 1.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding XkdW PF09636.5 AIC14409.1 - 0.85 9.5 3.1 0.74 9.7 0.5 2.1 1 1 1 2 2 2 0 XkdW protein TMF_DNA_bd PF12329.3 AIC14409.1 - 0.89 9.4 10.2 0.28 10.9 5.0 1.8 2 0 0 2 2 1 0 TATA element modulatory factor 1 DNA binding AATF-Che1 PF13339.1 AIC14409.1 - 1.1 9.4 9.1 0.99 9.5 4.7 1.8 1 1 1 2 2 2 0 Apoptosis antagonizing transcription factor DUF972 PF06156.8 AIC14409.1 - 1.6 9.1 8.0 7.7 6.9 4.7 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF972) eIF3_N PF09440.5 AIC14409.1 - 1.6 8.8 5.5 0.98 9.5 2.0 1.8 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain DivIC PF04977.10 AIC14409.1 - 4.7 6.7 7.0 2.5 7.6 1.9 2.2 1 1 1 2 2 2 0 Septum formation initiator DUF4200 PF13863.1 AIC14409.1 - 8.4 6.3 11.0 4.1 7.3 5.0 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Copper-bind PF00127.15 AIC14410.1 - 2e-06 27.9 0.0 0.027 14.6 0.0 2.4 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC14410.1 - 0.0082 16.0 0.3 0.12 12.2 0.0 2.5 2 1 0 2 2 2 1 Cupredoxin-like domain DUF1451 PF07295.6 AIC14411.1 - 0.0085 15.8 0.3 0.0089 15.8 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1451) A2L_zn_ribbon PF08792.5 AIC14411.1 - 0.011 15.2 2.9 0.27 10.7 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain TF_Zn_Ribbon PF08271.7 AIC14411.1 - 0.074 12.3 0.6 0.16 11.2 0.4 1.7 1 1 0 1 1 1 0 TFIIB zinc-binding zf-ribbon_3 PF13248.1 AIC14411.1 - 0.08 12.1 0.7 0.86 8.8 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 AIC14411.1 - 0.088 12.3 0.8 0.27 10.7 0.2 1.9 2 0 0 2 2 2 0 zinc-ribbon domain DUF4182 PF13790.1 AIC14411.1 - 0.26 11.1 1.8 1.5 8.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4182) DZR PF12773.2 AIC14412.1 - 0.0078 16.0 8.3 0.12 12.2 5.8 2.1 1 1 0 1 1 1 1 Double zinc ribbon Ribosomal_L32p PF01783.18 AIC14412.1 - 0.027 14.6 1.3 0.027 14.6 0.9 2.1 1 1 1 2 2 2 0 Ribosomal L32p protein family zf-MYND PF01753.13 AIC14412.1 - 0.072 12.9 3.9 0.78 9.6 2.7 2.1 1 1 0 1 1 1 0 MYND finger DUF3133 PF11331.3 AIC14412.1 - 0.31 10.6 2.2 0.51 9.9 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3133) Ribosomal_L40e PF01020.12 AIC14412.1 - 0.73 9.4 5.3 0.23 11.1 1.8 1.6 1 1 1 2 2 2 0 Ribosomal L40e family zf-ribbon_3 PF13248.1 AIC14412.1 - 1.1 8.5 8.0 9.3 5.6 2.2 2.5 2 1 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.7 AIC14412.1 - 1.4 8.8 6.5 3 7.7 4.5 1.7 1 1 0 1 1 1 0 zinc-ribbons zf-Sec23_Sec24 PF04810.10 AIC14412.1 - 1.7 8.3 9.8 0.18 11.4 3.5 2.0 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger DUF4379 PF14311.1 AIC14412.1 - 3.5 7.4 6.4 11 5.9 4.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4379) DUF35_N PF12172.3 AIC14412.1 - 5.8 6.9 10.8 0.72 9.8 2.4 2.3 1 1 1 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_5 PF13719.1 AIC14414.1 - 0.011 15.2 1.2 0.061 12.9 0.2 2.1 2 0 0 2 2 2 0 zinc-ribbon domain RRN7 PF11781.3 AIC14414.1 - 0.017 14.6 0.2 0.042 13.3 0.1 1.8 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 HypA PF01155.14 AIC14414.1 - 0.026 14.1 0.2 0.03 14.0 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Stc1 PF12898.2 AIC14414.1 - 0.03 14.3 0.6 0.039 14.0 0.4 1.2 1 0 0 1 1 1 0 Stc1 domain zinc_ribbon_4 PF13717.1 AIC14414.1 - 0.038 13.7 1.1 0.19 11.4 0.2 2.0 2 0 0 2 2 2 0 zinc-ribbon domain DUF1757 PF08560.5 AIC14414.1 - 0.12 12.0 0.1 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1757) FlgD_ig PF13860.1 AIC14415.1 - 9.8e-12 44.4 1.2 9.8e-12 44.4 0.8 2.6 2 1 1 3 3 3 1 FlgD Ig-like domain CHU_C PF13585.1 AIC14415.1 - 0.0058 16.4 0.0 0.011 15.5 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of CHU protein family N6_N4_Mtase PF01555.13 AIC14416.1 - 3.4e-41 141.2 0.0 4.9e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 AIC14416.1 - 5e-13 49.1 0.0 2e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain UPF0020 PF01170.13 AIC14416.1 - 6.5e-06 25.8 0.0 0.0012 18.4 0.0 2.2 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_18 PF12847.2 AIC14416.1 - 1.5e-05 25.5 0.1 0.00015 22.3 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC14416.1 - 7.1e-05 22.4 0.0 0.0022 17.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14416.1 - 0.00028 21.3 0.0 0.27 11.7 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_15 PF09445.5 AIC14416.1 - 0.014 15.0 0.1 0.041 13.4 0.0 1.7 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.1 AIC14416.1 - 0.085 13.2 0.0 0.61 10.4 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_12 PF08242.7 AIC14416.1 - 0.093 13.2 0.0 1.7 9.1 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Profilin PF00235.14 AIC14418.1 - 0.11 12.6 0.0 0.59 10.2 0.0 1.8 2 0 0 2 2 2 0 Profilin AmoC PF04896.7 AIC14419.1 - 6.6e-16 58.0 5.7 7.8e-16 57.8 4.0 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C OAD_gamma PF04277.8 AIC14419.1 - 0.19 12.1 2.0 1.2 9.5 0.0 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain NMN_transporter PF04973.7 AIC14419.1 - 1.5 8.2 9.7 4.6 6.6 6.7 1.9 1 1 0 1 1 1 0 Nicotinamide mononucleotide transporter YjeF_N PF03853.10 AIC14420.1 - 1.9e-47 161.0 0.1 2.3e-47 160.7 0.1 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Lactamase_B PF00753.22 AIC14421.1 - 1.4e-25 90.0 0.9 1.7e-25 89.7 0.6 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 AIC14421.1 - 3.6e-05 23.4 0.1 7.3e-05 22.3 0.1 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain DUF4261 PF14080.1 AIC14421.1 - 0.022 14.5 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4261) DBI_PRT PF02277.12 AIC14422.1 - 5.8e-32 111.0 4.1 5.8e-32 111.0 2.9 1.3 2 0 0 2 2 2 1 Phosphoribosyltransferase Abhydrolase_5 PF12695.2 AIC14422.1 - 0.12 12.0 0.3 0.77 9.5 0.5 2.1 2 1 0 2 2 2 0 Alpha/beta hydrolase family DUF4292 PF14125.1 AIC14423.1 - 0.017 14.5 0.0 0.03 13.7 0.0 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4292) Pur_DNA_glyco PF02245.11 AIC14424.1 - 9.9e-64 213.8 0.0 1.1e-63 213.7 0.0 1.0 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) UDG PF03167.14 AIC14425.1 - 9.6e-43 145.2 0.0 1.2e-42 144.9 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Gram_pos_anchor PF00746.16 AIC14426.1 - 0.011 15.4 7.8 0.27 11.0 0.2 2.1 2 0 0 2 2 2 0 Gram positive anchor Transglut_core2 PF13369.1 AIC14427.1 - 3e-38 130.6 0.0 5e-38 129.9 0.0 1.3 1 0 0 1 1 1 1 Transglutaminase-like superfamily TPR_9 PF13371.1 AIC14427.1 - 1.3e-11 44.1 0.6 2.4e-11 43.3 0.4 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.23 AIC14427.1 - 0.0023 17.4 0.0 0.0059 16.1 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.12 AIC14427.1 - 0.0034 17.1 0.0 0.0097 15.7 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.1 AIC14427.1 - 0.0067 16.0 0.0 0.026 14.1 0.0 1.7 1 1 0 1 1 1 1 TPR repeat TPR_14 PF13428.1 AIC14427.1 - 0.008 16.7 0.1 0.025 15.2 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.1 AIC14427.1 - 0.0086 16.7 0.5 0.0086 16.7 0.4 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.1 AIC14427.1 - 0.0099 15.7 0.5 0.22 11.5 0.2 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.1 AIC14427.1 - 0.014 15.5 0.0 0.087 13.0 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 AIC14427.1 - 0.017 15.4 0.7 0.041 14.2 0.5 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.1 AIC14427.1 - 0.055 13.2 0.0 0.22 11.3 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Ammonium_transp PF00909.16 AIC14428.1 - 1.6e-118 395.6 37.5 2.2e-118 395.1 26.0 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family Na_H_Exchanger PF00999.16 AIC14430.1 - 7.1e-65 218.9 60.0 9.3e-65 218.5 41.6 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Frankia_peptide PF14407.1 AIC14431.1 - 0.0021 17.7 0.0 0.003 17.2 0.0 1.3 1 0 0 1 1 1 1 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. LigA PF07746.6 AIC14431.1 - 0.058 13.4 0.0 0.076 13.0 0.0 1.2 1 0 0 1 1 1 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit OGG_N PF07934.7 AIC14432.1 - 1.2e-16 60.6 0.0 2.6e-16 59.6 0.0 1.5 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HhH-GPD PF00730.20 AIC14432.1 - 6.7e-12 45.6 0.0 1e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 AIC14432.1 - 4.7e-05 22.8 0.0 0.00012 21.5 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.2 AIC14432.1 - 0.0012 18.6 0.0 0.054 13.3 0.0 3.0 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_8 PF14716.1 AIC14432.1 - 0.053 13.7 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain AlkA_N PF06029.6 AIC14432.1 - 0.062 13.3 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 AlkA N-terminal domain HHH_5 PF14520.1 AIC14432.1 - 0.065 13.4 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain Antitoxin-MazE PF04014.13 AIC14435.1 - 0.058 13.1 0.4 0.1 12.3 0.2 1.4 1 0 0 1 1 1 0 Antidote-toxin recognition MazE Abhydrolase_6 PF12697.2 AIC14436.1 - 3.5e-41 141.5 0.0 4.1e-41 141.3 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AIC14436.1 - 4.1e-27 95.2 0.0 5.5e-27 94.8 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AIC14436.1 - 2.8e-17 62.8 0.0 6.4e-17 61.6 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.8 AIC14436.1 - 0.00016 21.3 0.0 0.00037 20.1 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.5 AIC14436.1 - 0.0043 16.9 0.0 0.0094 15.8 0.0 1.5 1 0 0 1 1 1 1 TAP-like protein Ser_hydrolase PF06821.8 AIC14436.1 - 0.0047 16.5 0.0 1.2 8.7 0.0 2.3 2 0 0 2 2 2 2 Serine hydrolase Abhydrolase_2 PF02230.11 AIC14436.1 - 0.012 15.0 0.0 6.3 6.1 0.0 2.6 2 1 1 3 3 3 0 Phospholipase/Carboxylesterase Peptidase_S10 PF00450.17 AIC14436.1 - 0.027 13.6 0.0 0.075 12.1 0.0 1.6 2 0 0 2 2 2 0 Serine carboxypeptidase UPF0227 PF05728.7 AIC14436.1 - 0.03 14.0 0.0 0.071 12.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Hydrolase_4 PF12146.3 AIC14436.1 - 0.04 13.7 0.0 0.07 12.9 0.0 1.3 1 0 0 1 1 1 0 Putative lysophospholipase DLH PF01738.13 AIC14436.1 - 0.12 11.6 0.0 4.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family HTH_45 PF14947.1 AIC14437.1 - 9.7e-20 70.1 0.1 9.7e-20 70.1 0.1 1.4 2 0 0 2 2 2 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC14437.1 - 0.0055 16.3 0.1 0.0063 16.1 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) APC2 PF08672.6 AIC14437.1 - 0.075 13.2 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Anaphase promoting complex (APC) subunit 2 Mrr_N PF14338.1 AIC14437.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 1 0 1 1 1 0 Mrr N-terminal domain RRN7 PF11781.3 AIC14439.1 - 0.032 13.7 7.5 0.032 13.7 5.2 2.0 2 1 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 DUF2296 PF10058.4 AIC14439.1 - 0.032 13.9 1.3 0.063 13.0 0.9 1.5 1 0 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) zf-C3HC4_3 PF13920.1 AIC14439.1 - 0.049 13.2 0.3 3.2 7.4 0.1 2.1 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) OrfB_Zn_ribbon PF07282.6 AIC14439.1 - 0.071 12.7 0.3 0.12 12.0 0.2 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-CCHC_2 PF13696.1 AIC14439.1 - 0.073 12.5 0.1 0.073 12.5 0.1 1.6 2 0 0 2 2 2 0 Zinc knuckle PhnA_Zn_Ribbon PF08274.7 AIC14439.1 - 0.27 11.0 1.4 0.73 9.6 1.0 1.7 1 1 0 1 1 1 0 PhnA Zinc-Ribbon Prim_Zn_Ribbon PF08273.7 AIC14439.1 - 0.87 9.7 6.7 1.9 8.6 4.6 1.5 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase A2M_N_2 PF07703.9 AIC14440.1 - 0.024 14.4 0.1 0.029 14.1 0.1 1.1 1 0 0 1 1 1 0 Alpha-2-macroglobulin family N-terminal region Arrestin_C PF02752.17 AIC14440.1 - 0.09 12.8 0.3 0.11 12.6 0.2 1.1 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain SRX PF09201.5 AIC14440.1 - 0.17 11.5 1.4 5.4 6.6 0.2 2.1 1 1 1 2 2 2 0 SRX PQ-loop PF04193.9 AIC14441.1 - 0.08 12.4 3.5 0.21 11.1 0.2 2.1 1 1 1 2 2 2 0 PQ loop repeat DUF3955 PF13127.1 AIC14441.1 - 0.093 12.2 5.6 1.1 8.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3955) DUF989 PF06181.6 AIC14441.1 - 0.11 11.5 1.3 0.11 11.5 0.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF989) DUF4282 PF14110.1 AIC14441.1 - 0.55 10.4 9.1 0.71 10.1 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) DUF4229 PF14012.1 AIC14441.1 - 1.6 8.6 4.5 2.4 8.1 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4229) DUF2207 PF09972.4 AIC14441.1 - 3 6.2 6.3 3.1 6.2 4.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2905 PF11146.3 AIC14441.1 - 3.3 7.7 8.0 9.5 6.2 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2905) DUF3149 PF11346.3 AIC14441.1 - 5.2 6.6 10.4 0.71 9.4 3.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3149) CARD PF00619.16 AIC14442.1 - 0.034 13.9 0.3 0.037 13.8 0.2 1.2 1 0 0 1 1 1 0 Caspase recruitment domain Spc24 PF08286.6 AIC14442.1 - 0.061 13.0 1.0 0.065 12.9 0.7 1.1 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 bZIP_2 PF07716.10 AIC14442.1 - 0.086 12.6 0.6 0.39 10.5 0.1 2.0 2 0 0 2 2 2 0 Basic region leucine zipper FeoC PF09012.5 AIC14442.1 - 0.11 12.1 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 FeoC like transcriptional regulator TMF_DNA_bd PF12329.3 AIC14442.1 - 0.14 11.9 1.6 0.14 11.9 0.2 1.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Prefoldin_2 PF01920.15 AIC14442.1 - 0.15 11.8 0.9 0.19 11.5 0.3 1.5 1 1 0 1 1 1 0 Prefoldin subunit HALZ PF02183.13 AIC14442.1 - 0.15 11.8 0.9 0.22 11.2 0.6 1.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper SlyX PF04102.7 AIC14442.1 - 0.17 12.2 0.4 0.18 12.1 0.3 1.2 1 0 0 1 1 1 0 SlyX DMPK_coil PF08826.5 AIC14442.1 - 0.22 11.4 1.4 0.29 11.0 0.3 1.6 2 0 0 2 2 2 0 DMPK coiled coil domain like M PF02370.11 AIC14442.1 - 0.44 11.0 0.0 0.44 11.0 0.0 2.2 3 0 0 3 3 3 0 M protein repeat RHH_1 PF01402.16 AIC14443.1 - 4e-05 23.3 0.0 6.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family DDE_Tnp_IS240 PF13610.1 AIC14444.1 - 9.6e-26 90.4 0.7 1.5e-25 89.8 0.5 1.3 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC14444.1 - 8.1e-10 38.8 0.2 2.2e-09 37.4 0.1 1.7 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC14444.1 - 9e-08 31.6 0.0 1.9e-07 30.6 0.0 1.4 1 1 0 1 1 1 1 Transposase IS66 family rve_3 PF13683.1 AIC14444.1 - 1.9e-07 30.5 0.0 4.9e-07 29.1 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Transposase_mut PF00872.13 AIC14444.1 - 4.8e-06 25.3 0.2 0.00026 19.6 0.0 2.1 2 0 0 2 2 2 1 Transposase, Mutator family DNA_RNApol_7kD PF03604.8 AIC14444.1 - 0.016 14.6 3.0 1.9 8.0 0.1 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Tmemb_9 PF05434.6 AIC14444.1 - 0.017 14.8 0.8 0.017 14.8 0.5 1.9 2 0 0 2 2 2 0 TMEM9 Zn_Tnp_IS1 PF03811.8 AIC14444.1 - 0.048 13.1 5.9 0.1 12.0 4.1 1.6 1 0 0 1 1 1 0 InsA N-terminal domain HTH_28 PF13518.1 AIC14444.1 - 0.091 12.7 0.2 0.73 9.9 0.1 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain zinc_ribbon_4 PF13717.1 AIC14444.1 - 0.26 11.0 3.4 0.89 9.3 2.4 2.0 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC14444.1 - 0.61 9.7 4.1 2.4 7.8 2.9 2.0 1 1 1 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.13 AIC14444.1 - 7.8 6.2 7.1 5.4 6.7 0.6 3.0 3 0 0 3 3 3 0 Transcription factor S-II (TFIIS) DUF4293 PF14126.1 AIC14445.1 - 0.0089 15.9 4.6 0.022 14.6 3.2 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4293) DUF3311 PF11755.3 AIC14445.1 - 0.017 14.6 0.7 0.039 13.4 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3311) Peptidase_M50 PF02163.17 AIC14445.1 - 0.092 11.6 1.2 1.5 7.7 0.0 2.4 2 1 0 2 2 2 0 Peptidase family M50 DUF4014 PF13198.1 AIC14445.1 - 1.9 8.9 11.5 1.2 9.5 5.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4014) Copper-bind PF00127.15 AIC14446.1 - 4e-10 39.8 0.0 5.5e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC14446.1 - 2.3e-05 24.2 0.0 5e-05 23.1 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain Cytochrom_B_N_2 PF13631.1 AIC14447.1 - 1.7e-24 86.5 10.5 1.7e-24 86.5 7.3 3.8 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.12 AIC14447.1 - 3.9e-08 33.4 1.1 3.9e-08 33.4 0.7 3.8 3 1 2 5 5 5 1 Cytochrome b(C-terminal)/b6/petD DUF1469 PF07332.6 AIC14447.1 - 0.042 13.5 0.0 0.042 13.5 0.0 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1469) SseB PF07179.7 AIC14447.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 SseB protein N-terminal domain CAMSAP_CH PF11971.3 AIC14447.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 CAMSAP CH domain UPF0542 PF15086.1 AIC14447.1 - 0.32 10.7 0.1 0.32 10.7 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 Rieske PF00355.21 AIC14448.1 - 2.5e-08 33.3 0.0 3.9e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_signal PF10518.4 AIC14448.1 - 0.00051 19.8 0.2 0.0011 18.8 0.1 1.5 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.4 AIC14448.1 - 0.0016 17.5 0.1 0.0031 16.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Pentapeptide PF00805.17 AIC14449.1 - 5.7e-27 92.4 22.0 1.7e-11 43.0 1.6 4.7 1 1 3 5 5 5 4 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.1 AIC14449.1 - 9.3e-15 54.2 1.6 3.1e-11 42.9 0.7 2.5 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.1 AIC14449.1 - 8.6e-11 41.5 0.2 6e-06 26.0 0.2 3.5 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) TP_methylase PF00590.15 AIC14450.1 - 2.5e-20 73.1 0.4 1.9e-19 70.1 0.0 2.0 1 1 1 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF357 PF04010.8 AIC14450.1 - 1.1e-10 40.9 0.1 2.8e-10 39.7 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF357) Peptidase_M20 PF01546.23 AIC14451.1 - 9e-29 100.3 0.0 1.2e-28 99.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 AIC14451.1 - 3.3e-13 49.3 0.0 6.3e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M42 PF05343.9 AIC14451.1 - 0.00042 19.1 0.0 0.22 10.2 0.0 2.8 2 1 1 3 3 3 2 M42 glutamyl aminopeptidase Peptidase_M28 PF04389.12 AIC14451.1 - 0.0026 17.5 0.1 0.0076 16.0 0.0 1.9 3 0 0 3 3 3 1 Peptidase family M28 RimK PF08443.6 AIC14452.1 - 1.7e-47 161.3 0.0 2.4e-47 160.9 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain ATP-grasp_4 PF13535.1 AIC14452.1 - 2e-09 37.4 0.0 3e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain GSH-S_ATP PF02955.11 AIC14452.1 - 7.7e-09 34.9 0.0 1.1e-08 34.3 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.9 AIC14452.1 - 3.9e-07 30.0 0.0 6.3e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 AIC14452.1 - 1.1e-06 28.1 0.0 4.6e-06 26.0 0.0 2.1 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.1 AIC14452.1 - 2.1e-05 23.4 0.1 0.00025 19.9 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 AIC14452.1 - 0.00019 20.8 0.0 0.00052 19.3 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.1 AIC14452.1 - 0.019 14.2 0.0 0.036 13.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain zinc_ribbon_5 PF13719.1 AIC14453.1 - 3.4e-06 26.5 2.8 0.0015 18.0 2.4 2.3 1 1 1 2 2 2 2 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC14453.1 - 4e-06 26.4 6.9 0.00047 19.7 2.2 2.3 1 1 1 2 2 2 2 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC14453.1 - 0.00012 21.1 0.7 0.078 12.2 0.0 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zf-HYPF PF07503.7 AIC14453.1 - 0.00013 21.3 1.4 0.0013 18.0 1.0 2.0 1 1 0 1 1 1 1 HypF finger Prok-RING_1 PF14446.1 AIC14453.1 - 0.00026 20.6 3.0 0.00096 18.8 2.1 1.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 PhnA_Zn_Ribbon PF08274.7 AIC14453.1 - 0.00041 20.0 0.7 0.25 11.1 0.0 2.1 2 0 0 2 2 2 2 PhnA Zinc-Ribbon UPF0547 PF10571.4 AIC14453.1 - 0.00079 19.0 5.1 0.028 14.1 0.3 2.2 2 0 0 2 2 2 1 Uncharacterised protein family UPF0547 TerY-C PF15616.1 AIC14453.1 - 0.0011 18.8 0.3 0.018 14.9 0.2 2.0 1 1 0 1 1 1 1 TerY-C metal binding domain zinc_ribbon_2 PF13240.1 AIC14453.1 - 0.0011 18.3 1.4 0.17 11.4 0.0 2.2 2 0 0 2 2 2 1 zinc-ribbon domain zf-IS66 PF13005.2 AIC14453.1 - 0.0053 16.7 1.7 0.36 10.8 0.2 2.6 2 1 0 2 2 2 1 zinc-finger binding domain of transposase IS66 zf-C4_Topoisom PF01396.14 AIC14453.1 - 0.0054 16.2 0.8 1.5 8.3 0.0 2.1 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger DNA_ligase_ZBD PF03119.11 AIC14453.1 - 0.0058 16.3 3.6 0.57 9.9 0.5 2.5 2 1 0 2 2 2 2 NAD-dependent DNA ligase C4 zinc finger domain A2L_zn_ribbon PF08792.5 AIC14453.1 - 0.0078 15.6 1.9 0.11 12.0 0.1 2.1 2 0 0 2 2 2 1 A2L zinc ribbon domain HypA PF01155.14 AIC14453.1 - 0.008 15.8 0.1 0.0085 15.7 0.1 1.0 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family TF_Zn_Ribbon PF08271.7 AIC14453.1 - 0.0095 15.2 2.2 0.016 14.5 1.5 1.4 1 1 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.6 AIC14453.1 - 0.0099 15.5 0.2 0.013 15.0 0.1 1.1 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DZR PF12773.2 AIC14453.1 - 0.0099 15.6 0.9 0.018 14.8 0.6 1.5 1 1 0 1 1 1 1 Double zinc ribbon zinc-ribbons_6 PF07191.7 AIC14453.1 - 0.018 14.8 1.3 0.11 12.2 0.9 1.9 1 1 0 1 1 1 0 zinc-ribbons zf-CSL PF05207.8 AIC14453.1 - 0.021 14.3 0.6 0.028 13.9 0.4 1.3 1 0 0 1 1 1 0 CSL zinc finger Lar_restr_allev PF14354.1 AIC14453.1 - 0.024 14.9 2.2 0.1 12.9 1.5 1.8 1 1 0 1 1 1 0 Restriction alleviation protein Lar ADK_lid PF05191.9 AIC14453.1 - 0.028 14.0 0.7 0.08 12.6 0.0 1.9 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf-TFIIB PF13453.1 AIC14453.1 - 0.028 13.5 2.6 0.044 12.9 1.8 1.3 1 0 0 1 1 1 0 Transcription factor zinc-finger CpXC PF14353.1 AIC14453.1 - 0.03 14.2 1.1 3.7 7.5 0.1 2.1 1 1 1 2 2 2 0 CpXC protein zf-RING_3 PF14369.1 AIC14453.1 - 0.031 14.2 3.0 0.085 12.8 2.0 1.7 1 1 0 1 1 1 0 zinc-finger Rubredoxin PF00301.15 AIC14453.1 - 0.032 14.0 1.4 3.4 7.6 0.0 2.4 2 0 0 2 2 2 0 Rubredoxin Zn-ribbon_8 PF09723.5 AIC14453.1 - 0.034 14.0 3.5 0.2 11.6 2.5 1.9 1 1 0 1 1 1 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.8 AIC14453.1 - 0.036 13.5 3.1 0.12 11.8 2.1 1.8 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DUF329 PF03884.9 AIC14453.1 - 0.046 13.2 2.6 3.4 7.3 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF329) COX5B PF01215.14 AIC14453.1 - 0.083 12.5 0.2 0.13 11.8 0.1 1.5 1 1 0 1 1 1 0 Cytochrome c oxidase subunit Vb Cys_rich_CPXG PF14255.1 AIC14453.1 - 0.1 12.4 0.9 11 5.8 0.1 2.1 2 0 0 2 2 2 0 Cysteine-rich CPXCG Zn_Tnp_IS1 PF03811.8 AIC14453.1 - 0.11 12.0 1.1 6.7 6.2 0.1 2.2 2 0 0 2 2 2 0 InsA N-terminal domain zf-H2C2_2 PF13465.1 AIC14453.1 - 0.11 12.8 0.7 7.4 7.0 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Sgf11 PF08209.6 AIC14453.1 - 0.11 11.7 1.3 4.9 6.5 0.0 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) DUF164 PF02591.10 AIC14453.1 - 0.14 11.9 4.6 0.46 10.3 0.1 2.3 1 1 1 2 2 2 0 Putative zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 AIC14453.1 - 0.15 11.8 2.4 1.3 8.8 0.1 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF2387 PF09526.5 AIC14453.1 - 0.29 11.0 1.8 0.4 10.6 1.3 1.3 1 1 0 1 1 1 0 Probable metal-binding protein (DUF2387) Ogr_Delta PF04606.7 AIC14453.1 - 0.37 10.4 2.1 13 5.4 0.2 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger DUF3797 PF12677.2 AIC14453.1 - 0.53 9.9 2.8 3.3 7.3 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) Ribosomal_S27e PF01667.12 AIC14453.1 - 0.64 9.6 2.5 2.6 7.6 1.7 1.8 1 1 1 2 2 2 0 Ribosomal protein S27 HMGL-like PF00682.14 AIC14454.1 - 3.7e-64 216.6 0.4 5.1e-64 216.1 0.3 1.2 1 0 0 1 1 1 1 HMGL-like Lyase_1 PF00206.15 AIC14455.1 - 1.9e-54 184.9 0.0 3e-54 184.3 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.1 AIC14455.1 - 3.1e-13 49.5 0.7 1.4e-12 47.4 0.0 2.5 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal RNase_PH_C PF03725.10 AIC14455.1 - 0.073 13.0 0.4 4.2 7.3 0.0 2.7 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 DUF59 PF01883.14 AIC14457.1 - 1.5e-13 50.5 0.1 2.2e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function DUF59 TFX_C PF14601.1 AIC14457.1 - 0.068 12.9 0.5 1.5 8.6 0.1 2.1 2 0 0 2 2 2 0 DNA_binding protein, TFX, C-term BNR PF02012.15 AIC14458.1 - 8.6e-06 24.8 4.7 12 6.2 0.0 5.9 5 0 0 5 5 5 4 BNR/Asp-box repeat BNR_2 PF13088.1 AIC14458.1 - 2.1e-05 23.9 0.0 0.6 9.3 0.0 4.0 2 1 0 2 2 2 2 BNR repeat-like domain Fer2_3 PF13085.1 AIC14459.1 - 1.4e-28 98.9 0.1 5.3e-28 97.0 0.0 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.1 AIC14459.1 - 4e-11 42.7 3.2 1.6e-10 40.8 0.9 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.1 AIC14459.1 - 2.3e-09 37.4 3.0 2.7e-09 37.2 0.3 2.3 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 AIC14459.1 - 3.2e-09 37.0 5.1 2.4e-07 31.0 0.1 2.7 2 1 1 3 3 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 AIC14459.1 - 2.4e-07 30.8 2.2 1.1e-06 28.7 0.5 2.5 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 AIC14459.1 - 3e-07 30.6 2.3 3e-07 30.6 1.6 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 AIC14459.1 - 4.2e-07 29.6 1.4 4.2e-07 29.6 1.0 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer2 PF00111.22 AIC14459.1 - 1.1e-06 28.2 0.1 3.3e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4 PF00037.22 AIC14459.1 - 1.2e-05 24.7 1.0 1.2e-05 24.7 0.7 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_16 PF13484.1 AIC14459.1 - 0.00029 21.5 2.3 0.00029 21.5 1.6 2.4 2 1 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4_2 PF12797.2 AIC14459.1 - 0.00046 19.9 0.9 0.00046 19.9 0.6 3.3 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_6 PF12837.2 AIC14459.1 - 0.0023 17.7 2.3 0.0023 17.7 1.6 2.9 3 0 0 3 3 2 1 4Fe-4S binding domain Fer4_4 PF12800.2 AIC14459.1 - 0.0052 17.0 1.6 0.0052 17.0 1.1 3.2 3 0 0 3 3 3 1 4Fe-4S binding domain Fer2_4 PF13510.1 AIC14459.1 - 0.051 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Fer4_3 PF12798.2 AIC14459.1 - 2.8 8.7 22.7 0.33 11.6 0.5 3.1 3 0 0 3 3 2 0 4Fe-4S binding domain Fer4_15 PF13459.1 AIC14459.1 - 3.9 8.1 8.2 0.7 10.4 0.1 2.8 3 0 0 3 3 2 0 4Fe-4S single cluster domain Fer4_21 PF14697.1 AIC14459.1 - 7.6 6.4 15.6 0.93 9.3 5.9 2.6 2 1 0 2 2 1 0 4Fe-4S dicluster domain Sdh_cyt PF01127.17 AIC14460.1 - 3.9e-09 36.3 5.4 5.4e-09 35.9 3.7 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Ferric_reduct PF01794.14 AIC14460.1 - 0.004 17.2 4.0 0.0067 16.5 2.8 1.5 1 1 0 1 1 1 1 Ferric reductase like transmembrane component DUF4405 PF14358.1 AIC14460.1 - 0.049 13.7 0.4 0.049 13.7 0.3 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) TRP PF06011.7 AIC14460.1 - 0.07 11.6 2.5 0.078 11.5 1.7 1.0 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF1129 PF06570.6 AIC14460.1 - 0.16 11.2 4.3 0.044 13.0 0.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) Arif-1 PF06770.6 AIC14460.1 - 0.17 11.2 6.7 0.21 10.9 4.7 1.0 1 0 0 1 1 1 0 Actin-rearrangement-inducing factor (Arif-1) DUF1691 PF07950.6 AIC14460.1 - 1.1 9.2 6.3 0.88 9.5 3.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1691) Sdh_cyt PF01127.17 AIC14461.1 - 1.4e-13 50.7 0.2 1.8e-13 50.3 0.1 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Ferric_reduct PF01794.14 AIC14461.1 - 0.0078 16.3 0.1 0.024 14.7 0.1 1.7 1 1 0 1 1 1 1 Ferric reductase like transmembrane component Fumarate_red_C PF02300.12 AIC14461.1 - 0.024 14.4 0.6 0.04 13.8 0.0 1.5 2 0 0 2 2 2 0 Fumarate reductase subunit C DUF1206 PF06724.6 AIC14461.1 - 6.8 6.5 10.8 5 6.9 1.0 3.1 1 1 1 3 3 3 0 Domain of Unknown Function (DUF1206) FAD_binding_2 PF00890.19 AIC14462.1 - 5.2e-95 318.7 0.2 6.9e-95 318.3 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.15 AIC14462.1 - 2.7e-39 133.9 0.7 4.6e-39 133.2 0.5 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.9 AIC14462.1 - 7.6e-06 25.9 0.1 0.00066 19.6 0.0 2.6 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 AIC14462.1 - 0.0084 15.2 2.3 0.095 11.7 1.6 2.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 AIC14462.1 - 0.012 14.5 0.2 0.028 13.3 0.1 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.17 AIC14462.1 - 0.021 13.7 0.4 0.039 12.8 0.3 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.7 AIC14462.1 - 0.044 12.7 0.4 0.067 12.0 0.3 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein HI0933_like PF03486.9 AIC14462.1 - 0.12 10.8 0.6 0.26 9.6 0.4 1.6 1 0 0 1 1 1 0 HI0933-like protein MTH865 PF07747.6 AIC14462.1 - 0.15 11.6 0.0 11 5.7 0.0 2.6 2 0 0 2 2 2 0 MTH865-like family Thi4 PF01946.12 AIC14462.1 - 0.24 10.4 2.4 0.71 8.9 0.4 2.2 2 0 0 2 2 2 0 Thi4 family TPR_1 PF00515.23 AIC14463.1 - 9.5e-09 34.5 1.4 1.4e-06 27.6 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.1 AIC14463.1 - 4e-07 30.5 0.6 0.00021 21.8 0.0 1.9 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.1 AIC14463.1 - 1e-06 28.3 0.4 1.6e-05 24.4 0.0 2.4 2 1 1 3 3 3 1 TPR repeat TPR_14 PF13428.1 AIC14463.1 - 7e-06 26.2 0.1 0.093 13.4 0.0 2.6 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_2 PF07719.12 AIC14463.1 - 8e-06 25.3 2.9 5.4e-05 22.7 0.0 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 AIC14463.1 - 2.5e-05 24.0 0.0 0.22 11.4 0.0 2.2 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.1 AIC14463.1 - 0.0015 18.3 0.0 0.0022 17.8 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.1 AIC14463.1 - 0.016 15.5 0.5 1.6 9.3 0.0 2.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.1 AIC14463.1 - 0.023 14.6 0.0 0.065 13.1 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.1 AIC14463.1 - 0.049 13.4 0.8 0.62 9.9 0.0 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat PDGF_N PF04692.8 AIC14463.1 - 0.06 13.8 0.0 0.12 12.8 0.0 1.6 1 1 0 1 1 1 0 Platelet-derived growth factor, N terminal region TPR_17 PF13431.1 AIC14463.1 - 0.073 13.3 0.2 8.3 6.8 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 AIC14463.1 - 0.11 12.8 2.0 3.1 8.1 0.2 2.3 2 1 0 3 3 3 0 Tetratricopeptide repeat DUF2899 PF11449.3 AIC14464.1 - 0.059 12.5 0.5 0.065 12.4 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2899) tRNA-synt_His PF13393.1 AIC14467.1 - 1.6e-39 135.8 0.0 2.4e-39 135.2 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase tRNA-synt_2b PF00587.20 AIC14467.1 - 6.2e-14 51.9 0.1 9.8e-14 51.3 0.1 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AIC14467.1 - 5.6e-12 45.4 0.1 1e-11 44.6 0.1 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.15 AIC14467.1 - 0.012 14.7 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) RHH_1 PF01402.16 AIC14468.1 - 0.0061 16.4 3.4 1.2 9.1 0.0 3.5 4 0 0 4 4 4 1 Ribbon-helix-helix protein, copG family DUF2870 PF11069.3 AIC14468.1 - 0.0066 16.4 1.2 0.0075 16.2 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) DUF2129 PF09902.4 AIC14468.1 - 0.017 14.8 0.1 0.024 14.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2129) ASL_C PF08328.6 AIC14468.1 - 0.024 14.4 0.2 0.027 14.3 0.2 1.2 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal zf-HC2 PF13490.1 AIC14468.1 - 0.1 12.5 2.8 0.65 10.0 0.0 2.6 3 0 0 3 3 3 0 Putative zinc-finger PIN PF01850.16 AIC14469.1 - 9.5e-11 42.0 0.3 1.2e-10 41.7 0.2 1.1 1 0 0 1 1 1 1 PIN domain Archease PF01951.11 AIC14470.1 - 4.9e-38 130.1 0.2 5.5e-38 130.0 0.1 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) HSP20 PF00011.16 AIC14471.1 - 3.1e-20 71.9 1.6 5.1e-20 71.2 1.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family CS PF04969.11 AIC14471.1 - 0.097 13.2 0.7 0.48 11.0 0.5 2.1 1 1 0 1 1 1 0 CS domain HATPase_c_5 PF14501.1 AIC14472.1 - 0.027 14.1 0.0 0.027 14.1 0.0 1.0 1 0 0 1 1 1 0 GHKL domain N6_Mtase PF02384.11 AIC14474.1 - 8.3e-13 48.0 0.0 1e-08 34.6 0.0 2.4 2 0 0 2 2 2 2 N-6 DNA Methylase Methyltransf_26 PF13659.1 AIC14474.1 - 4.6e-11 42.7 0.0 2e-10 40.6 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 AIC14474.1 - 2.2e-06 27.3 0.0 0.00023 20.8 0.0 2.5 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 Eco57I PF07669.6 AIC14474.1 - 0.00028 21.2 0.0 0.0012 19.2 0.0 2.1 1 0 0 1 1 1 1 Eco57I restriction-modification methylase YcxB PF14317.1 AIC14474.1 - 0.00083 18.5 0.4 0.063 12.5 0.0 3.2 3 0 0 3 3 3 1 YcxB-like protein TaqI_C PF12950.2 AIC14474.1 - 0.0033 17.1 0.9 0.014 15.1 0.0 2.4 2 0 0 2 2 2 1 TaqI-like C-terminal specificity domain MTS PF05175.9 AIC14474.1 - 0.0038 16.6 0.0 0.38 10.1 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase small domain Ferritin PF00210.19 AIC14476.1 - 4.3e-19 68.6 0.0 6.2e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.12 AIC14476.1 - 0.033 14.5 0.0 0.047 14.0 0.0 1.2 1 0 0 1 1 1 0 Rubrerythrin HTH_36 PF13730.1 AIC14477.1 - 0.00068 19.7 0.0 0.0014 18.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_7 PF02796.10 AIC14477.1 - 0.00071 19.3 0.0 0.0014 18.3 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase DUF2250 PF10007.4 AIC14477.1 - 0.00085 19.1 0.0 0.0066 16.3 0.0 1.9 1 1 1 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_IclR PF09339.5 AIC14477.1 - 0.0011 18.5 0.0 0.0024 17.4 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.1 AIC14477.1 - 0.0017 17.7 0.0 0.0034 16.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TBPIP PF07106.8 AIC14477.1 - 0.0028 17.2 0.4 0.0039 16.7 0.3 1.4 1 1 0 1 1 1 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TrmB PF01978.14 AIC14477.1 - 0.0054 16.4 0.0 0.0072 16.0 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Mga PF05043.8 AIC14477.1 - 0.0057 16.9 0.1 0.01 16.0 0.1 1.4 1 0 0 1 1 1 1 Mga helix-turn-helix domain HTH_11 PF08279.7 AIC14477.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.4 1 0 0 1 1 1 0 HTH domain Rrf2 PF02082.15 AIC14477.1 - 0.045 13.8 0.0 0.16 12.0 0.0 1.8 1 1 1 2 2 2 0 Transcriptional regulator HTH_23 PF13384.1 AIC14477.1 - 0.045 13.4 0.0 0.076 12.6 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain Phage_X PF05155.10 AIC14477.1 - 0.069 13.0 0.0 0.13 12.2 0.0 1.5 1 1 0 1 1 1 0 Phage X family FUR PF01475.14 AIC14477.1 - 0.07 13.0 0.0 0.092 12.6 0.0 1.2 1 0 0 1 1 1 0 Ferric uptake regulator family RAP1 PF07218.6 AIC14477.1 - 0.072 11.1 0.1 0.08 11.0 0.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) HTH_26 PF13443.1 AIC14477.1 - 0.083 13.1 0.0 0.21 11.7 0.0 1.7 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain CENP-B_N PF04218.8 AIC14477.1 - 0.092 12.1 0.1 1.5 8.2 0.0 2.6 2 1 1 3 3 3 0 CENP-B N-terminal DNA-binding domain DUF1492 PF07374.6 AIC14477.1 - 0.11 12.6 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) Phage_AlpA PF05930.7 AIC14477.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Prophage CP4-57 regulatory protein (AlpA) XPG_I PF00867.13 AIC14478.1 - 2e-23 82.2 0.0 3.9e-23 81.3 0.0 1.5 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.12 AIC14478.1 - 2.8e-19 69.2 0.0 6e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.15 AIC14478.1 - 2.2e-05 24.6 0.0 5.3e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.1 AIC14478.1 - 0.0018 18.3 0.0 0.0056 16.8 0.0 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH_2 PF12826.2 AIC14478.1 - 0.034 14.0 0.0 2.2 8.2 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif Peptidase_M50 PF02163.17 AIC14478.1 - 0.082 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M50 MCM PF00493.18 AIC14479.1 - 9.5e-07 27.9 0.2 0.0042 15.9 0.0 2.5 2 2 0 2 2 2 2 MCM2/3/5 family Sigma54_activat PF00158.21 AIC14479.1 - 2.2e-05 23.9 0.0 9.4e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.7 AIC14479.1 - 0.00017 20.7 0.1 0.00029 19.9 0.0 1.4 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_3 PF07726.6 AIC14479.1 - 0.00037 20.0 0.0 0.0026 17.3 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.9 AIC14479.1 - 0.0018 18.0 0.1 0.15 11.7 0.0 2.2 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 AIC14479.1 - 0.0078 16.3 0.0 0.25 11.4 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA PF00004.24 AIC14479.1 - 0.013 15.6 0.4 0.068 13.3 0.1 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DNA_pol3_delta2 PF13177.1 AIC14479.1 - 0.083 12.5 0.1 1.2 8.7 0.1 2.6 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Glyco_hydro_14 PF01373.12 AIC14480.1 - 0.00013 20.8 0.0 0.00013 20.8 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 zf-NADH-PPase PF09297.6 AIC14481.1 - 0.00095 18.6 3.5 0.059 12.8 0.5 2.2 2 0 0 2 2 2 2 NADH pyrophosphatase zinc ribbon domain TFIIS_C PF01096.13 AIC14481.1 - 0.0089 15.6 2.2 0.31 10.7 0.1 2.5 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.5 AIC14481.1 - 0.033 14.1 5.5 4.8 7.2 3.8 2.2 1 1 0 1 1 1 0 Zinc ribbon domain DZR PF12773.2 AIC14481.1 - 0.045 13.5 1.0 0.065 13.0 0.7 1.2 1 0 0 1 1 1 0 Double zinc ribbon TF_Zn_Ribbon PF08271.7 AIC14481.1 - 0.094 12.0 1.0 3.4 7.0 0.0 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding DUF4191 PF13829.1 AIC14481.1 - 0.28 10.2 3.1 0.31 10.1 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Ogr_Delta PF04606.7 AIC14481.1 - 0.52 9.9 5.2 0.96 9.1 0.7 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zinc_ribbon_2 PF13240.1 AIC14481.1 - 0.89 9.1 4.5 11 5.5 3.2 2.0 1 1 0 1 1 1 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC14481.1 - 1 8.6 4.9 15 4.9 3.4 2.1 1 1 0 1 1 1 0 zinc-ribbon domain UbiA PF01040.13 AIC14481.1 - 1 8.5 7.3 1.2 8.2 5.0 1.1 1 0 0 1 1 1 0 UbiA prenyltransferase family Zn_Tnp_IS1595 PF12760.2 AIC14481.1 - 1.4 8.7 5.8 3.6 7.4 0.5 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-C2H2_4 PF13894.1 AIC14483.1 - 0.0025 18.0 0.4 0.0035 17.5 0.3 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC14483.1 - 0.027 14.7 0.2 0.039 14.3 0.2 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type DUF1752 PF08550.5 AIC14483.1 - 0.051 13.1 0.3 0.39 10.3 0.0 2.1 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1752) zf-H2C2_2 PF13465.1 AIC14483.1 - 0.14 12.5 0.7 5.8 7.4 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Prok-JAB PF14464.1 AIC14485.1 - 6.2e-09 35.3 0.0 1.5e-08 34.1 0.0 1.6 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain DDE_Tnp_IS240 PF13610.1 AIC14486.1 - 8.9e-10 38.6 0.0 1.4e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC14486.1 - 2.3e-05 24.4 0.2 4.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC14486.1 - 0.00017 20.8 0.6 0.00033 19.9 0.3 1.6 1 1 0 1 1 1 1 Transposase IS66 family DUF4206 PF13901.1 AIC14486.1 - 0.029 13.9 0.7 0.04 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) PqqD PF05402.7 AIC14487.1 - 1.5e-06 28.1 0.0 1.8e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) eIF-5a PF01287.15 AIC14487.1 - 0.048 13.6 0.1 0.069 13.1 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold PI3_PI4_kinase PF00454.22 AIC14487.1 - 0.12 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase CHB_HEX_C PF03174.8 AIC14489.1 - 2.4e-37 126.6 28.1 5.9e-20 70.8 3.0 3.8 3 1 1 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 AIC14489.1 - 1.6e-31 108.1 19.5 3.5e-16 59.0 3.1 3.1 2 0 0 2 2 2 2 Fn3 associated CHB_HEX_C_1 PF13290.1 AIC14489.1 - 1.1e-30 105.1 28.3 2.5e-17 62.3 3.5 3.9 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain Polysacc_deac_1 PF01522.16 AIC14489.1 - 3.3e-10 39.6 0.1 8.5e-10 38.3 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase HYR PF02494.11 AIC14489.1 - 5.2e-09 35.9 7.8 7.5e-07 29.0 0.4 4.0 3 1 0 3 3 3 2 HYR domain Big_3_4 PF13754.1 AIC14489.1 - 0.00089 19.5 13.3 0.0062 16.8 0.8 7.0 8 0 0 8 8 8 2 Bacterial Ig-like domain (group 3) Abhydrolase_1 PF00561.15 AIC14490.1 - 4.1e-14 52.7 0.1 1.4e-13 50.9 0.1 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold PhaC_N PF07167.8 AIC14490.1 - 1.4e-12 47.4 0.0 2.8e-12 46.4 0.0 1.5 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Abhydrolase_6 PF12697.2 AIC14490.1 - 7.2e-12 45.6 0.0 1.2e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AIC14490.1 - 2.9e-08 33.5 0.0 1.8e-05 24.5 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family DUF3141 PF11339.3 AIC14490.1 - 0.0007 18.0 0.0 0.0013 17.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3141) PHB_depo_C PF06850.6 AIC14490.1 - 0.0021 17.2 0.0 0.019 14.1 0.0 2.2 3 0 0 3 3 3 1 PHB de-polymerase C-terminus DLH PF01738.13 AIC14490.1 - 0.018 14.3 0.0 0.29 10.3 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family DUF1626 PF07788.6 AIC14490.1 - 0.03 14.1 0.1 0.058 13.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1626) FSH1 PF03959.8 AIC14490.1 - 0.11 11.8 0.0 0.52 9.7 0.0 2.0 1 1 0 1 1 1 0 Serine hydrolase (FSH1) PHA_synth_III_E PF09712.5 AIC14491.1 - 1.4e-18 67.3 0.4 4.4e-18 65.7 0.3 1.7 1 1 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) SRP1_TIP1 PF00660.12 AIC14491.1 - 9.2e-05 22.2 0.4 0.00071 19.3 0.1 2.6 2 1 0 2 2 2 1 Seripauperin and TIP1 family DUF4413 PF14372.1 AIC14491.1 - 0.033 14.1 0.5 0.14 12.1 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4413) DUF2730 PF10805.3 AIC14491.1 - 0.12 12.0 0.4 1.5 8.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) Monooxygenase_B PF04744.7 AIC14492.1 - 0.0043 15.7 0.0 0.0083 14.8 0.0 1.3 1 0 0 1 1 1 1 Monooxygenase subunit B protein FAM195 PF14799.1 AIC14494.1 - 0.0037 17.0 0.0 0.0049 16.7 0.0 1.2 1 0 0 1 1 1 1 FAM195 family DUF2120 PF09893.4 AIC14494.1 - 0.028 14.3 1.0 0.034 14.0 0.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) DMA PF03474.9 AIC14496.1 - 0.051 13.4 0.1 3.5 7.5 0.0 2.2 2 0 0 2 2 2 0 DMRTA motif Lant_dehyd_C PF04738.8 AIC14496.1 - 0.15 10.2 0.0 0.19 9.8 0.0 1.1 1 0 0 1 1 1 0 Lantibiotic dehydratase, C terminus HTH_Crp_2 PF13545.1 AIC14497.1 - 0.0031 17.2 0.0 0.0046 16.7 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TrmB PF01978.14 AIC14497.1 - 0.063 12.9 0.1 0.13 11.9 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.1 AIC14497.1 - 0.079 12.6 0.2 0.98 9.1 0.0 2.2 1 1 1 2 2 2 0 Homeodomain-like domain Tfb2 PF03849.9 AIC14497.1 - 0.09 11.4 0.1 0.097 11.2 0.0 1.1 1 0 0 1 1 1 0 Transcription factor Tfb2 MarR_2 PF12802.2 AIC14497.1 - 0.092 12.4 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 MarR family Transglut_C PF00927.17 AIC14499.1 - 0.028 14.4 0.1 0.041 13.9 0.1 1.4 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain Gmad2 PF10648.4 AIC14499.1 - 0.048 13.8 0.1 0.11 12.7 0.0 1.6 1 1 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination FixH PF05751.6 AIC14499.1 - 0.11 12.3 1.2 1.5 8.6 0.8 2.1 1 1 0 1 1 1 0 FixH ATP-grasp_5 PF13549.1 AIC14502.1 - 3.7e-63 212.7 0.2 5.2e-63 212.2 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.1 AIC14502.1 - 1.1e-45 154.6 0.1 3.3e-45 153.0 0.0 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 AIC14502.1 - 2.3e-21 76.1 0.0 5.5e-21 74.8 0.0 1.7 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.14 AIC14502.1 - 1.1e-11 45.0 0.2 5.2e-11 42.9 0.1 2.3 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_4 PF13535.1 AIC14502.1 - 0.0026 17.5 0.0 0.0078 15.9 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_2 PF08442.5 AIC14502.1 - 0.013 14.8 0.1 0.031 13.6 0.1 1.7 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp PF02222.17 AIC14502.1 - 0.11 11.8 0.0 0.27 10.5 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain GATase PF00117.23 AIC14503.1 - 4.4e-22 78.4 0.0 7e-22 77.8 0.0 1.3 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AIC14503.1 - 1.1e-07 31.5 0.1 2.9e-07 30.1 0.1 1.8 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.19 AIC14503.1 - 0.0037 16.7 0.0 0.0052 16.2 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.9 AIC14503.1 - 0.017 14.7 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Toprim_4 PF13662.1 AIC14504.1 - 4.1e-07 29.9 0.0 6.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Toprim domain Toprim PF01751.17 AIC14504.1 - 6.9e-06 25.9 0.1 0.00056 19.8 0.0 2.2 1 1 0 1 1 1 1 Toprim domain Toprim_2 PF13155.1 AIC14504.1 - 0.027 14.7 0.0 0.038 14.2 0.0 1.4 1 1 0 1 1 1 0 Toprim-like RinB PF06116.7 AIC14504.1 - 0.064 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Transcriptional activator RinB Toprim_4 PF13662.1 AIC14505.1 - 3.9e-09 36.3 0.5 9.9e-09 35.0 0.4 1.7 1 0 0 1 1 1 1 Toprim domain Toprim PF01751.17 AIC14505.1 - 0.0095 15.8 0.6 0.046 13.7 0.4 2.1 1 1 0 1 1 1 1 Toprim domain Toprim_2 PF13155.1 AIC14505.1 - 0.014 15.6 0.0 0.033 14.5 0.0 1.6 1 0 0 1 1 1 0 Toprim-like GRP PF07172.6 AIC14505.1 - 0.19 12.2 12.2 0.39 11.2 8.4 1.5 1 0 0 1 1 1 0 Glycine rich protein family CTP-dep_RFKase PF01982.11 AIC14506.1 - 1.2e-41 141.1 0.0 1.7e-41 140.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF120 MarR_2 PF12802.2 AIC14506.1 - 0.00028 20.5 0.1 0.00049 19.7 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.2 AIC14506.1 - 0.0013 18.4 0.1 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_34 PF13601.1 AIC14506.1 - 0.0025 17.8 0.1 0.0084 16.1 0.0 1.9 2 0 0 2 2 2 1 Winged helix DNA-binding domain MarR PF01047.17 AIC14506.1 - 0.0028 17.3 0.0 0.0051 16.4 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 AIC14506.1 - 0.0032 17.7 0.1 0.0062 16.8 0.1 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.14 AIC14506.1 - 0.0047 16.6 0.0 0.009 15.7 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC14506.1 - 0.012 14.9 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.11 AIC14506.1 - 0.098 12.2 0.0 0.26 10.8 0.0 1.7 1 0 0 1 1 1 0 LexA DNA binding domain HTH_11 PF08279.7 AIC14506.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 HTH domain CTP_transf_2 PF01467.21 AIC14507.1 - 2.6e-08 34.0 0.3 8.4e-08 32.4 0.2 1.8 1 1 0 1 1 1 1 Cytidylyltransferase MazG PF03819.12 AIC14507.1 - 0.0032 17.3 0.0 0.94 9.4 0.0 2.5 2 0 0 2 2 2 2 MazG nucleotide pyrophosphohydrolase domain Methyltransf_31 PF13847.1 AIC14508.1 - 1.3e-28 99.4 0.0 4.1e-28 97.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC14508.1 - 3.1e-18 66.0 0.0 5.4e-18 65.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14508.1 - 2.9e-16 60.0 0.0 8.7e-16 58.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14508.1 - 3.6e-16 59.4 0.0 6.6e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC14508.1 - 4.5e-16 59.1 0.0 8.5e-16 58.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC14508.1 - 1.1e-09 38.5 0.0 2.5e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC14508.1 - 9.7e-09 34.6 0.1 1.8e-08 33.8 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 AIC14508.1 - 2.6e-08 33.2 0.0 4.2e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_26 PF13659.1 AIC14508.1 - 4.6e-08 33.1 0.0 1.1e-07 31.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC14508.1 - 6e-08 32.2 0.0 9.8e-08 31.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.12 AIC14508.1 - 9.5e-08 31.3 0.0 5.1e-07 28.9 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase PCMT PF01135.14 AIC14508.1 - 7e-06 25.7 0.0 1e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.7 AIC14508.1 - 6.9e-05 21.8 0.1 0.00015 20.7 0.0 1.6 2 0 0 2 2 2 1 DREV methyltransferase PrmA PF06325.8 AIC14508.1 - 0.00049 19.3 0.0 0.0007 18.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_2 PF00891.13 AIC14508.1 - 0.00086 18.5 0.0 0.057 12.5 0.0 2.2 2 0 0 2 2 2 1 O-methyltransferase MetW PF07021.7 AIC14508.1 - 0.0016 17.8 0.0 0.0029 17.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.1 AIC14508.1 - 0.0036 16.9 0.0 0.006 16.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 AIC14508.1 - 0.009 15.4 0.0 0.026 13.9 0.0 1.6 1 1 1 2 2 2 1 Nodulation protein S (NodS) DUF938 PF06080.7 AIC14508.1 - 0.021 14.3 0.0 0.044 13.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF938) FmrO PF07091.6 AIC14508.1 - 0.023 13.7 0.0 0.039 12.9 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) Methyltransf_9 PF08003.6 AIC14508.1 - 0.024 13.3 0.0 0.033 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) DUF650 PF04894.7 AIC14509.1 - 8.9e-83 277.9 0.0 1.3e-82 277.3 0.0 1.1 1 0 0 1 1 1 1 Archaeal protein of unknown function (DUF650) DUF651 PF04895.7 AIC14509.1 - 2.5e-37 126.8 0.0 4.5e-37 126.0 0.0 1.4 1 0 0 1 1 1 1 Archaeal protein of unknown function (DUF651) rve PF00665.21 AIC14511.1 - 1.2e-22 80.2 0.1 2.8e-22 79.0 0.0 1.7 2 0 0 2 2 1 1 Integrase core domain HTH_29 PF13551.1 AIC14511.1 - 3e-17 62.7 0.3 1.3e-15 57.4 0.2 2.3 2 0 0 2 2 2 1 Winged helix-turn helix HTH_28 PF13518.1 AIC14511.1 - 6e-16 58.1 5.2 5.3e-14 51.8 0.4 3.2 3 0 0 3 3 3 2 Helix-turn-helix domain LZ_Tnp_IS481 PF13011.1 AIC14511.1 - 9.3e-12 45.1 0.3 7.8e-10 38.9 0.0 2.9 3 0 0 3 3 3 1 leucine-zipper of insertion element IS481 HTH_32 PF13565.1 AIC14511.1 - 1.3e-11 45.1 1.6 2.2e-11 44.3 0.3 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.1 AIC14511.1 - 1.9e-11 43.2 7.2 6.6e-11 41.5 0.1 3.1 3 0 0 3 3 3 1 Homeodomain-like domain rve_3 PF13683.1 AIC14511.1 - 2.1e-09 36.7 0.0 1.4e-08 34.0 0.0 2.3 2 0 0 2 2 2 1 Integrase core domain HTH_Tnp_1 PF01527.15 AIC14511.1 - 1.1e-07 31.6 0.0 3.9e-07 29.9 0.0 1.9 2 0 0 2 2 2 1 Transposase HTH_7 PF02796.10 AIC14511.1 - 0.0029 17.4 2.8 0.025 14.4 0.1 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_21 PF13276.1 AIC14511.1 - 0.0077 16.2 1.3 0.0077 16.2 0.9 2.1 2 0 0 2 2 2 1 HTH-like domain DUF4581 PF15167.1 AIC14511.1 - 0.011 15.6 0.0 0.018 14.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4581) HTH_Tnp_IS630 PF01710.11 AIC14511.1 - 0.014 15.0 2.9 0.066 12.8 0.0 2.6 3 0 0 3 3 3 0 Transposase HTH_36 PF13730.1 AIC14511.1 - 0.014 15.4 1.7 0.18 11.9 0.2 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain CENP-B_N PF04218.8 AIC14511.1 - 0.017 14.5 0.0 0.047 13.1 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain Terminase_5 PF06056.7 AIC14511.1 - 0.02 14.4 2.2 0.064 12.8 0.0 2.4 3 0 0 3 3 2 0 Putative ATPase subunit of terminase (gpP-like) HTH_Tnp_Tc3_2 PF01498.13 AIC14511.1 - 0.035 14.1 0.2 0.16 12.0 0.1 2.1 2 0 0 2 2 2 0 Transposase DDE_Tnp_IS240 PF13610.1 AIC14511.1 - 0.038 13.9 0.4 0.071 13.0 0.3 1.4 1 0 0 1 1 1 0 DDE domain rve_2 PF13333.1 AIC14511.1 - 0.049 13.6 0.0 0.15 12.1 0.0 1.8 1 0 0 1 1 1 0 Integrase core domain HTH_33 PF13592.1 AIC14511.1 - 0.054 13.0 0.2 0.16 11.4 0.1 1.8 1 0 0 1 1 1 0 Winged helix-turn helix HTH_AraC PF00165.18 AIC14511.1 - 0.096 12.5 0.1 0.35 10.7 0.0 2.1 2 0 0 2 2 1 0 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_17 PF12728.2 AIC14511.1 - 0.12 12.6 5.8 7.3 6.9 0.1 3.2 3 0 0 3 3 2 0 Helix-turn-helix domain ProRS-C_1 PF09180.6 AIC14512.1 - 1.6e-25 88.8 0.5 4e-25 87.5 0.4 1.8 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.15 AIC14512.1 - 6.2e-20 70.9 0.7 1.2e-19 70.0 0.5 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.20 AIC14512.1 - 2.7e-18 66.1 0.0 5.1e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) SNARE_assoc PF09335.6 AIC14513.1 - 6.3e-16 58.6 1.9 6.3e-16 58.6 1.3 2.5 2 1 1 3 3 3 1 SNARE associated Golgi protein Nramp PF01566.13 AIC14513.1 - 0.12 11.0 5.7 0.081 11.7 0.5 2.3 2 1 1 3 3 3 0 Natural resistance-associated macrophage protein SieB PF14163.1 AIC14513.1 - 3.5 7.1 5.3 0.6 9.6 1.1 1.6 2 0 0 2 2 2 0 Superinfection exclusion protein B DUF2387 PF09526.5 AIC14515.1 - 0.00046 20.0 0.9 0.0005 19.9 0.6 1.1 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) zinc_ribbon_4 PF13717.1 AIC14515.1 - 0.0014 18.2 0.9 0.32 10.7 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC14515.1 - 0.0018 17.8 1.2 0.35 10.4 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain C1_4 PF07975.7 AIC14515.1 - 0.013 15.4 2.4 0.032 14.2 1.7 1.6 1 1 1 2 2 2 0 TFIIH C1-like domain Zn_Tnp_IS1595 PF12760.2 AIC14515.1 - 0.031 14.0 0.5 0.035 13.9 0.3 1.1 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-TFIIB PF13453.1 AIC14515.1 - 0.038 13.1 3.2 0.07 12.3 2.2 1.5 1 1 0 1 1 1 0 Transcription factor zinc-finger OrfB_Zn_ribbon PF07282.6 AIC14515.1 - 0.074 12.7 0.7 0.076 12.6 0.5 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc-ribbons_6 PF07191.7 AIC14515.1 - 0.075 12.8 0.6 0.1 12.4 0.4 1.3 1 1 0 1 1 1 0 zinc-ribbons Zn-ribbon_8 PF09723.5 AIC14515.1 - 0.088 12.7 1.1 9.2 6.3 0.1 2.1 2 0 0 2 2 2 0 Zinc ribbon domain PhnA_Zn_Ribbon PF08274.7 AIC14515.1 - 0.098 12.4 0.1 0.13 12.0 0.1 1.3 1 1 0 1 1 1 0 PhnA Zinc-Ribbon C1_1 PF00130.17 AIC14515.1 - 0.16 11.7 0.7 0.19 11.5 0.5 1.1 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RNA_POL_M_15KD PF02150.11 AIC14515.1 - 0.26 11.0 1.9 1.3 8.7 1.3 1.9 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit Auto_anti-p27 PF06677.7 AIC14515.1 - 0.27 11.0 4.2 0.45 10.3 2.9 1.6 1 1 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TFIIS_C PF01096.13 AIC14515.1 - 0.85 9.3 4.4 3.3 7.4 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-H2C2_2 PF13465.1 AIC14515.1 - 9 6.7 7.6 2.1 8.7 0.2 2.1 1 1 1 2 2 2 0 Zinc-finger double domain SMC_N PF02463.14 AIC14516.1 - 7.8e-62 208.3 0.0 1.6e-61 207.3 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 AIC14516.1 - 4.2e-17 63.0 0.4 2.2e-08 34.4 0.0 2.7 2 1 0 2 2 2 2 AAA domain AAA_23 PF13476.1 AIC14516.1 - 2.1e-14 54.3 23.9 2.1e-14 54.3 16.6 6.2 2 2 1 3 3 2 1 AAA domain SMC_hinge PF06470.8 AIC14516.1 - 9.2e-14 51.4 0.0 3.3e-13 49.6 0.0 2.0 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_15 PF13175.1 AIC14516.1 - 3.7e-07 29.5 1.6 9.6e-06 24.8 0.8 3.8 3 1 0 3 3 2 2 AAA ATPase domain DUF869 PF05911.6 AIC14516.1 - 4.1e-07 28.6 65.6 2.8e-06 25.9 15.5 3.7 3 1 1 4 4 4 3 Plant protein of unknown function (DUF869) AAA_29 PF13555.1 AIC14516.1 - 2.1e-06 27.1 0.0 4.9e-06 25.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Reo_sigmaC PF04582.7 AIC14516.1 - 6.8e-06 25.4 34.7 0.018 14.2 0.2 5.3 2 2 4 7 7 7 6 Reovirus sigma C capsid protein AAA_13 PF13166.1 AIC14516.1 - 0.00027 19.5 66.8 0.021 13.3 1.5 6.3 4 2 2 6 6 6 3 AAA domain DUF812 PF05667.6 AIC14516.1 - 0.00077 18.0 16.1 0.00077 18.0 11.1 4.0 2 2 1 3 3 2 1 Protein of unknown function (DUF812) ABC_tran PF00005.22 AIC14516.1 - 0.016 15.5 0.5 0.016 15.5 0.4 5.2 2 2 1 3 3 3 0 ABC transporter Spc7 PF08317.6 AIC14516.1 - 0.064 11.9 77.1 0.027 13.1 7.1 5.8 2 2 1 5 5 5 0 Spc7 kinetochore protein DUF4201 PF13870.1 AIC14516.1 - 0.12 11.7 64.4 0.013 14.9 3.5 6.7 2 2 3 6 6 6 0 Domain of unknown function (DUF4201) MscS_porin PF12795.2 AIC14516.1 - 0.36 10.0 88.8 0.34 10.2 6.1 5.7 2 2 3 5 5 5 0 Mechanosensitive ion channel porin domain AAA_25 PF13481.1 AIC14516.1 - 1.1 8.6 5.8 1.1 8.6 0.0 3.7 4 0 0 4 4 4 0 AAA domain NPV_P10 PF05531.7 AIC14516.1 - 1.2 9.4 21.1 0.87 9.8 0.0 6.4 4 2 2 7 7 7 0 Nucleopolyhedrovirus P10 protein Filament PF00038.16 AIC14516.1 - 2.7 7.3 83.0 0.04 13.4 14.6 6.2 2 2 1 6 6 6 0 Intermediate filament protein MtrG PF04210.8 AIC14516.1 - 6 6.6 10.6 5.6 6.7 0.0 5.3 5 1 1 6 6 6 0 Tetrahydromethanopterin S-methyltransferase, subunit G NAD_binding_5 PF07994.7 AIC14517.1 - 1.7e-49 168.9 0.0 1.7e-48 165.6 0.0 1.9 1 1 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 AIC14517.1 - 3.9e-26 91.0 0.0 6.1e-26 90.4 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Acetyltransf_7 PF13508.1 AIC14518.1 - 1.5e-07 31.4 0.0 3.6e-07 30.2 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 AIC14518.1 - 7.9e-06 25.8 0.0 1.3e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 AIC14518.1 - 0.00023 21.2 0.1 0.0012 18.9 0.0 2.0 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AIC14518.1 - 0.033 14.0 0.0 0.07 12.9 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain tRNA-synt_1e PF01406.14 AIC14519.1 - 3.6e-70 236.4 0.0 4.8e-70 236.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 AIC14519.1 - 8.4e-15 54.3 0.0 2e-07 30.0 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 AIC14519.1 - 4.6e-09 34.8 0.0 6.1e-07 27.8 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.13 AIC14519.1 - 8.5e-08 31.2 0.0 0.0067 15.1 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (K) DALR_2 PF09190.6 AIC14519.1 - 0.0004 20.5 1.1 0.0017 18.5 0.2 2.4 1 1 1 2 2 2 1 DALR domain tRNA-synt_1d PF00750.14 AIC14519.1 - 0.002 17.0 0.0 1.5 7.5 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (R) tRNA-synt_1c PF00749.16 AIC14519.1 - 0.0036 16.0 0.0 0.025 13.2 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Radical_SAM PF04055.16 AIC14520.1 - 3.8e-14 53.1 0.3 6.3e-14 52.4 0.2 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 AIC14520.1 - 2.4e-05 24.4 0.2 5.8e-05 23.2 0.1 1.6 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 AIC14520.1 - 6.1e-05 23.0 0.1 0.00012 22.1 0.1 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPASM PF13186.1 AIC14520.1 - 0.0026 18.0 0.6 0.0066 16.7 0.4 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain HAD_2 PF13419.1 AIC14520.1 - 0.024 14.8 0.0 0.07 13.3 0.0 1.7 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase LysE PF01810.13 AIC14521.1 - 1.1e-16 60.7 12.9 1.3e-16 60.4 8.9 1.1 1 0 0 1 1 1 1 LysE type translocator MerC PF03203.9 AIC14521.1 - 0.49 10.7 11.7 0.17 12.2 1.4 2.8 2 1 1 3 3 3 0 MerC mercury resistance protein Alba PF01918.16 AIC14522.1 - 6e-12 44.9 0.3 8.2e-12 44.5 0.2 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.3 AIC14522.1 - 0.019 14.5 0.5 0.05 13.2 0.3 1.7 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Waikav_capsid_1 PF12264.3 AIC14522.1 - 0.13 11.5 0.1 0.19 10.9 0.0 1.3 1 1 0 1 1 1 0 Waikavirus capsid protein 1 SGL PF08450.7 AIC14524.1 - 2.2e-09 37.0 2.0 0.0024 17.3 0.0 4.9 5 0 0 5 5 5 3 SMP-30/Gluconolaconase/LRE-like region Reg_prop PF07494.6 AIC14524.1 - 4e-07 29.2 5.1 8.8 6.7 0.2 6.7 6 0 0 6 6 6 3 Two component regulator propeller SBBP PF06739.6 AIC14524.1 - 0.00095 18.9 6.3 0.33 10.7 0.1 4.3 5 0 0 5 5 5 2 Beta-propeller repeat NHL PF01436.16 AIC14524.1 - 0.0015 18.3 3.6 1.1 9.3 0.0 5.0 6 0 0 6 6 6 1 NHL repeat EamA PF00892.15 AIC14525.1 - 1.4e-31 109.1 34.5 1.5e-16 60.5 5.5 2.4 2 0 0 2 2 2 2 EamA-like transporter family EmrE PF13536.1 AIC14525.1 - 4.8e-07 29.9 33.4 0.00015 21.9 2.9 3.0 2 2 0 2 2 2 2 Multidrug resistance efflux transporter PTH2 PF01981.11 AIC14526.1 - 7.7e-46 154.5 0.1 8.6e-46 154.3 0.1 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 DAO PF01266.19 AIC14527.1 - 1.3e-10 40.7 9.3 1e-06 27.8 0.2 2.3 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 AIC14527.1 - 1.3e-09 37.5 5.7 1.7e-07 30.6 0.5 2.2 1 1 0 2 2 2 2 FAD binding domain FAD_oxidored PF12831.2 AIC14527.1 - 2.2e-08 33.6 1.0 3.3e-08 33.0 0.7 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.9 AIC14527.1 - 2.3e-05 23.0 1.0 0.011 14.2 0.3 2.2 2 0 0 2 2 2 2 HI0933-like protein Thi4 PF01946.12 AIC14527.1 - 6.7e-05 22.1 0.6 0.00015 20.9 0.4 1.6 1 0 0 1 1 1 1 Thi4 family Lycopene_cycl PF05834.7 AIC14527.1 - 0.0005 19.1 0.6 0.16 10.8 0.6 2.5 2 1 0 2 2 2 2 Lycopene cyclase protein FAD_binding_2 PF00890.19 AIC14527.1 - 0.00056 18.8 3.4 0.00084 18.2 1.3 2.0 3 0 0 3 3 3 1 FAD binding domain Pyr_redox_2 PF07992.9 AIC14527.1 - 0.00059 19.7 0.3 0.0013 18.6 0.1 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.19 AIC14527.1 - 0.0022 17.1 5.5 0.15 11.0 1.0 2.9 3 0 0 3 3 3 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.1 AIC14527.1 - 0.0023 17.9 0.8 0.0023 17.9 0.5 3.0 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 AIC14527.1 - 0.0025 16.5 3.0 0.23 10.0 0.0 3.0 2 1 0 2 2 2 1 Tryptophan halogenase Pyr_redox_3 PF13738.1 AIC14527.1 - 0.023 14.7 0.3 0.045 13.8 0.2 1.6 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 AIC14527.1 - 0.16 10.7 3.3 0.5 9.1 2.2 1.8 1 1 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.22 AIC14527.1 - 3.8 7.9 6.2 3.2 8.2 1.0 2.9 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF1610 PF07754.6 AIC14528.1 - 1.8e-05 24.7 15.2 7.1e-05 22.8 3.4 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF1610) DZR PF12773.2 AIC14528.1 - 0.018 14.8 8.3 0.089 12.6 5.8 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC14528.1 - 0.039 13.1 0.9 0.039 13.1 0.6 3.0 2 1 1 3 3 3 0 zinc-ribbon domain CK_II_beta PF01214.13 AIC14528.1 - 0.11 12.0 1.5 0.11 11.9 1.0 1.1 1 0 0 1 1 1 0 Casein kinase II regulatory subunit Zn_Tnp_IS1595 PF12760.2 AIC14528.1 - 0.13 12.0 9.4 0.049 13.4 3.4 2.1 2 0 0 2 2 2 0 Transposase zinc-ribbon domain IBR PF01485.16 AIC14528.1 - 0.29 11.0 8.3 1.3 8.9 5.8 1.9 1 1 0 1 1 1 0 IBR domain C1_1 PF00130.17 AIC14528.1 - 0.3 10.8 6.7 0.24 11.1 0.9 2.0 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Spt4 PF06093.8 AIC14528.1 - 0.56 10.1 4.5 0.65 9.9 3.1 1.3 1 1 0 1 1 1 0 Spt4/RpoE2 zinc finger OrfB_Zn_ribbon PF07282.6 AIC14528.1 - 0.66 9.6 7.1 0.59 9.8 1.4 2.1 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Prok-RING_1 PF14446.1 AIC14528.1 - 1.8 8.3 7.1 0.18 11.5 0.9 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 NOB1_Zn_bind PF08772.6 AIC14528.1 - 6.1 6.7 6.6 0.32 10.8 0.7 1.7 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like DUF164 PF02591.10 AIC14528.1 - 9 6.2 7.1 8.3 6.3 0.3 2.9 3 0 0 3 3 3 0 Putative zinc ribbon domain A2L_zn_ribbon PF08792.5 AIC14528.1 - 9.1 5.8 8.8 77 2.9 0.1 3.1 2 1 0 2 2 2 0 A2L zinc ribbon domain zinc_ribbon_2 PF13240.1 AIC14528.1 - 9.6 5.8 14.4 3.7 7.1 5.0 3.0 2 1 0 2 2 2 0 zinc-ribbon domain EF1_GNE PF00736.14 AIC14529.1 - 6.8e-17 60.9 0.1 7.3e-17 60.8 0.0 1.0 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain AAA PF00004.24 AIC14530.1 - 9.5e-92 304.1 0.0 3.4e-48 163.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 AIC14530.1 - 9.3e-27 92.8 1.0 2.7e-26 91.3 0.1 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 AIC14530.1 - 4.4e-14 52.7 0.0 2.4e-08 34.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_22 PF13401.1 AIC14530.1 - 4.3e-13 49.5 0.1 0.0012 18.9 0.0 4.4 2 2 0 2 2 2 2 AAA domain RuvB_N PF05496.7 AIC14530.1 - 8.1e-13 47.9 0.0 2e-07 30.3 0.0 2.7 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 AIC14530.1 - 1.5e-12 47.8 0.0 0.00011 22.2 0.0 3.1 2 1 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.9 AIC14530.1 - 5.5e-12 45.5 0.3 2.8e-05 23.8 0.0 4.5 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.1 AIC14530.1 - 1.6e-11 44.2 0.0 1.8e-06 27.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_17 PF13207.1 AIC14530.1 - 2.1e-11 44.7 0.6 4.2e-05 24.3 0.0 3.1 2 1 0 2 2 2 2 AAA domain AAA_33 PF13671.1 AIC14530.1 - 7.1e-10 38.9 0.0 5.2e-05 23.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 AIC14530.1 - 6.1e-09 35.5 4.7 0.092 12.1 0.1 4.4 2 2 1 4 4 4 2 AAA domain IstB_IS21 PF01695.12 AIC14530.1 - 7.3e-09 35.2 0.1 0.0035 16.8 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein TIP49 PF06068.8 AIC14530.1 - 2.7e-08 32.9 0.2 0.0039 15.9 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus RNA_helicase PF00910.17 AIC14530.1 - 1.4e-07 31.6 0.0 0.012 15.8 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.1 AIC14530.1 - 2.6e-07 30.7 0.0 0.0048 16.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.1 AIC14530.1 - 3.5e-07 30.5 0.0 0.012 15.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 AIC14530.1 - 6.7e-07 29.2 0.1 0.0096 15.6 0.0 3.5 2 1 1 3 3 3 1 Archaeal ATPase Sigma54_activat PF00158.21 AIC14530.1 - 1.2e-06 28.1 0.2 0.1 12.0 0.0 3.5 3 1 0 3 3 2 2 Sigma-54 interaction domain Zeta_toxin PF06414.7 AIC14530.1 - 1.4e-06 27.5 0.0 0.0063 15.6 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin ABC_tran PF00005.22 AIC14530.1 - 1.4e-06 28.6 0.0 0.018 15.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter PhoH PF02562.11 AIC14530.1 - 1.6e-06 27.5 1.9 0.15 11.2 0.0 3.5 2 1 1 3 3 3 2 PhoH-like protein Mg_chelatase PF01078.16 AIC14530.1 - 1.6e-06 27.4 0.7 0.0069 15.5 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.1 AIC14530.1 - 2e-06 27.9 0.0 0.036 14.1 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain CDC48_2 PF02933.12 AIC14530.1 - 2.5e-06 27.0 0.4 6.1e-06 25.7 0.3 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 KaiC PF06745.8 AIC14530.1 - 6.8e-06 25.3 0.4 0.29 10.2 0.0 3.3 2 1 1 3 3 3 2 KaiC AAA_19 PF13245.1 AIC14530.1 - 9.5e-06 25.2 1.3 0.029 14.0 0.0 2.8 2 0 0 2 2 2 2 Part of AAA domain ResIII PF04851.10 AIC14530.1 - 1.1e-05 25.3 0.0 0.14 11.9 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit ATP-synt_ab PF00006.20 AIC14530.1 - 1.3e-05 24.7 0.0 0.022 14.2 0.0 2.5 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain AAA_24 PF13479.1 AIC14530.1 - 2.4e-05 24.0 0.6 0.2 11.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 AIC14530.1 - 4.5e-05 22.6 0.1 0.021 13.8 0.0 2.5 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.12 AIC14530.1 - 0.00013 20.9 0.2 0.13 11.1 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 DEAD PF00270.24 AIC14530.1 - 0.00023 20.6 1.1 3.2 7.2 0.0 4.1 2 2 2 4 4 4 0 DEAD/DEAH box helicase DUF815 PF05673.8 AIC14530.1 - 0.00044 19.2 0.0 0.42 9.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Bac_DnaA PF00308.13 AIC14530.1 - 0.0012 18.5 0.0 0.49 9.9 0.0 3.0 4 0 0 4 4 2 1 Bacterial dnaA protein NACHT PF05729.7 AIC14530.1 - 0.0029 17.3 0.3 7.1 6.2 0.0 3.7 4 0 0 4 4 3 0 NACHT domain SKI PF01202.17 AIC14530.1 - 0.0029 17.4 0.2 4.9 7.0 0.0 3.2 3 0 0 3 3 3 0 Shikimate kinase T2SE PF00437.15 AIC14530.1 - 0.003 16.5 0.1 1.2 8.0 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_3 PF07726.6 AIC14530.1 - 0.0051 16.4 0.0 0.44 10.1 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Guanylate_kin PF00625.16 AIC14530.1 - 0.01 15.2 0.4 20 4.5 0.0 3.9 2 2 2 4 4 4 0 Guanylate kinase AAA_21 PF13304.1 AIC14530.1 - 0.01 15.7 2.9 1.3 8.9 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_30 PF13604.1 AIC14530.1 - 0.013 15.1 0.0 5.3 6.5 0.0 2.5 2 0 0 2 2 2 0 AAA domain Vps4_C PF09336.5 AIC14530.1 - 0.013 15.3 0.1 0.15 12.0 0.0 2.5 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain IPT PF01745.11 AIC14530.1 - 0.014 14.6 0.2 0.88 8.6 0.1 2.4 2 0 0 2 2 2 0 Isopentenyl transferase UPF0079 PF02367.12 AIC14530.1 - 0.029 14.0 0.1 8.9 5.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_23 PF13476.1 AIC14530.1 - 0.03 14.6 0.8 4.7 7.4 0.1 2.9 2 0 0 2 2 2 0 AAA domain Herpes_TK PF00693.13 AIC14530.1 - 0.03 13.4 0.0 1.5 7.9 0.0 2.2 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus AAA_11 PF13086.1 AIC14530.1 - 0.04 13.4 0.0 1.8 8.0 0.0 2.5 2 0 0 2 2 2 0 AAA domain Disulph_isomer PF06491.6 AIC14530.1 - 0.04 13.7 0.0 11 5.9 0.0 2.6 2 0 0 2 2 2 0 Disulphide isomerase SRPRB PF09439.5 AIC14530.1 - 0.079 12.1 0.0 19 4.4 0.0 2.8 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.1 AIC14530.1 - 0.12 11.8 0.4 2.7 7.5 0.1 2.3 2 0 0 2 2 2 0 P-loop containing region of AAA domain Rad17 PF03215.10 AIC14530.1 - 0.14 10.8 0.1 8.3 4.9 0.0 2.7 2 1 1 3 3 3 0 Rad17 cell cycle checkpoint protein NB-ARC PF00931.17 AIC14530.1 - 0.16 10.7 0.1 14 4.3 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain DUF258 PF03193.11 AIC14530.1 - 0.21 10.7 0.0 2.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF258 NTPase_1 PF03266.10 AIC14530.1 - 0.91 9.2 4.0 37 3.9 0.0 4.0 3 2 1 4 4 4 0 NTPase DUF1456 PF07308.8 AIC14531.1 - 0.0068 16.4 0.2 0.0094 15.9 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1456) UbiA PF01040.13 AIC14532.1 - 1e-29 103.5 27.0 1.4e-29 103.1 18.7 1.2 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF4231 PF14015.1 AIC14532.1 - 2.3 8.2 9.1 0.59 10.1 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF4231) PepSY_TM_3 PF13706.1 AIC14532.1 - 2.4 7.6 17.4 12 5.4 0.1 3.9 3 0 0 3 3 3 0 PepSY-associated TM helix Copper-bind PF00127.15 AIC14534.1 - 1.3e-17 63.7 2.5 6e-08 32.8 0.2 2.7 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC14534.1 - 2.3e-12 46.7 0.0 3.6e-06 26.8 0.0 2.5 2 1 0 2 2 2 2 Cupredoxin-like domain DUF2061 PF09834.4 AIC14534.1 - 0.086 13.0 2.8 0.28 11.4 1.9 2.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2061) Prok-JAB PF14464.1 AIC14535.1 - 4.2e-15 55.1 0.0 4.9e-15 54.9 0.0 1.0 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.16 AIC14535.1 - 0.00088 18.9 0.0 0.0012 18.5 0.0 1.3 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease tRNA-synt_2 PF00152.15 AIC14536.1 - 5e-86 288.5 0.0 7e-86 288.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AIC14536.1 - 1.5e-09 37.5 0.5 3.1e-09 36.5 0.4 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 AIC14536.1 - 0.00013 21.2 0.2 0.047 12.8 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) tRNA-synt_2b PF00587.20 AIC14536.1 - 0.14 11.6 0.0 0.79 9.2 0.0 2.0 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) KH_5 PF13184.1 AIC14537.1 - 9.9e-07 28.4 0.1 3.4e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 NusA-like KH domain ABC_tran PF00005.22 AIC14539.1 - 3.6e-25 88.8 0.0 5.5e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.7 AIC14539.1 - 5.6e-23 81.0 0.3 9.4e-23 80.3 0.2 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.1 AIC14539.1 - 4.1e-13 49.9 0.4 6.5e-10 39.4 0.1 2.2 1 1 1 2 2 2 2 AAA domain AAA_18 PF13238.1 AIC14539.1 - 0.0014 18.9 0.0 0.017 15.4 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 AIC14539.1 - 0.0018 17.3 0.1 0.013 14.5 0.0 1.9 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.14 AIC14539.1 - 0.0037 16.5 0.4 0.025 13.8 0.0 2.0 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.4 AIC14539.1 - 0.006 15.2 0.8 0.46 8.9 0.1 2.4 2 1 0 2 2 2 1 Predicted ATPase of the ABC class AAA_16 PF13191.1 AIC14539.1 - 0.0067 16.4 0.2 0.017 15.1 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_25 PF13481.1 AIC14539.1 - 0.014 14.7 0.1 4.1 6.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 AIC14539.1 - 0.035 14.2 1.3 0.63 10.1 0.9 2.1 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.1 AIC14539.1 - 0.042 13.3 0.0 0.081 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_17 PF13207.1 AIC14539.1 - 0.09 13.5 0.0 0.14 13.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF258 PF03193.11 AIC14539.1 - 0.18 10.9 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 Helicase_C_2 PF13307.1 AIC14540.1 - 6.9e-22 78.1 0.1 1.6e-21 76.9 0.0 1.7 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.10 AIC14540.1 - 2.6e-08 33.9 0.3 5.3e-06 26.3 0.0 2.9 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.10 AIC14540.1 - 1.5e-06 27.7 0.1 2.9e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.24 AIC14540.1 - 8.4e-05 22.1 0.0 0.45 9.9 0.0 2.7 2 0 0 2 2 2 2 DEAD/DEAH box helicase AAA_10 PF12846.2 AIC14540.1 - 0.00044 19.7 0.1 0.49 9.7 0.0 2.9 2 1 1 3 3 3 2 AAA-like domain Exosortase_EpsH PF09721.5 AIC14541.1 - 0.00064 19.0 22.1 0.004 16.3 15.3 2.4 1 1 0 1 1 1 1 Transmembrane exosortase (Exosortase_EpsH) IMS PF00817.15 AIC14542.1 - 4.1e-41 140.2 0.6 1.9e-40 138.1 0.1 2.0 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.3 AIC14542.1 - 6.4e-10 39.0 0.1 1.2e-09 38.2 0.1 1.4 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain HHH_5 PF14520.1 AIC14542.1 - 8.1e-09 35.5 0.3 3.4e-08 33.5 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain IMS_HHH PF11798.3 AIC14542.1 - 1.1e-06 28.3 0.0 2.6e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 IMS family HHH motif Cdd1 PF11731.3 AIC14542.1 - 0.0046 16.8 0.0 0.054 13.4 0.0 2.8 3 1 0 3 3 3 1 Pathogenicity locus HHH PF00633.18 AIC14542.1 - 0.032 13.9 0.4 0.13 12.0 0.0 2.3 3 0 0 3 3 3 0 Helix-hairpin-helix motif HHH_8 PF14716.1 AIC14542.1 - 0.069 13.3 0.0 1.2 9.3 0.0 2.8 3 0 0 3 3 3 0 Helix-hairpin-helix domain PGK PF00162.14 AIC14543.1 - 3e-131 437.5 0.1 3.3e-131 437.3 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF929 PF06053.6 AIC14544.1 - 1.3e-23 83.4 0.0 2.9e-23 82.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF929) AhpC-TSA PF00578.16 AIC14544.1 - 0.084 12.5 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 AhpC/TSA family Ribosomal_L16 PF00252.13 AIC14545.1 - 4.9e-28 97.5 0.3 6.4e-28 97.1 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA_int_endo PF01974.12 AIC14546.1 - 6.5e-20 70.7 0.2 1.4e-19 69.6 0.2 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 AIC14546.1 - 4.6e-07 29.2 0.3 8.8e-07 28.3 0.2 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain tRNA_int_end_N2 PF12928.2 AIC14546.1 - 0.085 12.3 0.1 0.21 11.0 0.0 1.6 1 0 0 1 1 1 0 tRNA-splicing endonuclease subunit sen54 N-term CreA PF05981.7 AIC14547.1 - 0.015 14.7 0.0 0.015 14.7 0.0 1.0 1 0 0 1 1 1 0 CreA protein HypA PF01155.14 AIC14549.1 - 0.063 12.9 2.2 0.083 12.5 1.5 1.3 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Opy2 PF09463.5 AIC14549.1 - 0.076 13.1 5.1 0.085 12.9 1.6 1.9 2 0 0 2 2 2 0 Opy2 protein Ribosomal_L32p PF01783.18 AIC14549.1 - 0.26 11.4 2.6 2.9 8.1 0.0 2.1 2 0 0 2 2 2 0 Ribosomal L32p protein family DZR PF12773.2 AIC14549.1 - 0.27 11.0 9.9 9.7 6.0 6.7 2.2 1 1 0 1 1 1 0 Double zinc ribbon DUF2797 PF10977.3 AIC14549.1 - 0.39 10.3 3.5 0.39 10.2 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2797) zinc-ribbons_6 PF07191.7 AIC14549.1 - 0.41 10.4 6.4 0.85 9.4 4.4 1.6 1 1 0 1 1 1 0 zinc-ribbons zf-C3HC4_3 PF13920.1 AIC14549.1 - 0.55 9.9 8.8 1.4 8.6 6.1 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.1 AIC14549.1 - 1.1 8.9 8.9 8.8 6.0 6.2 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.1 AIC14549.1 - 1.4 8.6 10.9 79 3.0 7.6 2.2 1 1 0 1 1 1 0 zinc-RING finger domain DUF2039 PF10217.4 AIC14549.1 - 1.6 8.8 5.7 2.1 8.4 4.0 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2039) DUF1272 PF06906.6 AIC14549.1 - 2.6 7.9 8.3 16 5.4 5.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) A2L_zn_ribbon PF08792.5 AIC14549.1 - 3.6 7.1 7.3 7 6.2 0.1 2.9 2 1 1 3 3 3 0 A2L zinc ribbon domain zf-ribbon_3 PF13248.1 AIC14549.1 - 5.4 6.3 9.9 11 5.3 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Fer4_4 PF12800.2 AIC14549.1 - 7.6 7.1 7.6 32 5.2 0.2 2.9 3 0 0 3 3 3 0 4Fe-4S binding domain zinc_ribbon_2 PF13240.1 AIC14549.1 - 9.1 5.9 11.9 14 5.2 0.7 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC14551.1 - 0.015 14.4 0.0 0.019 14.1 0.0 1.3 1 0 0 1 1 1 0 zinc-ribbon domain DNA_ligase_ZBD PF03119.11 AIC14551.1 - 0.034 13.8 0.6 0.047 13.3 0.4 1.2 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain TF_Zn_Ribbon PF08271.7 AIC14551.1 - 0.073 12.4 0.2 0.11 11.8 0.2 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding UPF0547 PF10571.4 AIC14551.1 - 0.1 12.3 0.3 0.13 11.9 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 TRAM PF01938.15 AIC14554.1 - 6e-14 51.5 1.9 8.2e-14 51.1 1.3 1.2 1 0 0 1 1 1 1 TRAM domain zf-C2H2_6 PF13912.1 AIC14555.1 - 0.0024 17.7 0.4 0.0038 17.0 0.2 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-DBF PF07535.7 AIC14555.1 - 0.035 13.7 2.0 0.049 13.3 1.4 1.3 1 0 0 1 1 1 0 DBF zinc finger zf-C2H2_2 PF12756.2 AIC14555.1 - 0.038 14.0 0.1 0.041 13.9 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.1 AIC14555.1 - 0.044 14.1 0.7 0.069 13.5 0.5 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC14555.1 - 0.065 13.6 0.3 0.09 13.1 0.2 1.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type CBS PF00571.23 AIC14556.1 - 3.4e-23 81.1 1.5 2e-14 53.0 0.1 2.1 2 0 0 2 2 2 2 CBS domain YfkB PF08756.5 AIC14556.1 - 0.12 11.9 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 YfkB-like domain zinc_ribbon_2 PF13240.1 AIC14557.1 - 2.6e-06 26.7 2.2 2.6e-06 26.7 1.5 2.0 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.2 AIC14557.1 - 0.00011 21.9 1.0 0.00024 20.8 0.7 1.6 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC14557.1 - 0.00039 19.5 3.7 0.00039 19.5 2.6 2.0 2 0 0 2 2 2 1 zinc-ribbon domain zf-RanBP PF00641.13 AIC14557.1 - 0.11 11.6 4.7 0.2 10.7 3.3 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others zf-DHHC PF01529.15 AIC14557.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase zf-B_box PF00643.19 AIC14557.1 - 0.15 11.9 0.9 0.23 11.4 0.6 1.3 1 0 0 1 1 1 0 B-box zinc finger Nudix_N_2 PF14803.1 AIC14557.1 - 3.8 7.2 4.6 2.5 7.8 0.1 2.5 3 0 0 3 3 3 0 Nudix N-terminal TGS PF02824.16 AIC14558.1 - 6.6e-22 77.1 0.0 1.4e-21 76.0 0.0 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.18 AIC14558.1 - 1.1e-19 70.4 0.0 2.8e-19 69.1 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.13 AIC14558.1 - 4e-15 55.4 0.2 3.3e-13 49.1 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.16 AIC14558.1 - 9e-05 21.7 0.2 0.03 13.5 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family AIG1 PF04548.11 AIC14558.1 - 0.0008 18.5 0.1 0.003 16.6 0.0 2.0 2 0 0 2 2 2 1 AIG1 family Dynamin_N PF00350.18 AIC14558.1 - 0.00092 19.0 0.0 0.29 10.9 0.1 2.6 1 1 1 2 2 2 1 Dynamin family Ras PF00071.17 AIC14558.1 - 0.00099 18.5 0.0 0.18 11.1 0.0 2.4 2 0 0 2 2 2 1 Ras family cobW PF02492.14 AIC14558.1 - 0.001 18.5 0.4 0.73 9.2 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain SRPRB PF09439.5 AIC14558.1 - 0.0011 18.2 0.2 0.0026 17.0 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit DNA_pol_A PF00476.15 AIC14558.1 - 0.0012 17.5 0.0 0.002 16.8 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family A DUF258 PF03193.11 AIC14558.1 - 0.0028 16.8 0.1 0.01 15.0 0.0 2.0 3 0 0 3 3 3 1 Protein of unknown function, DUF258 GTP_EFTU PF00009.22 AIC14558.1 - 0.0031 16.9 3.3 1 8.7 0.1 3.5 3 1 1 4 4 4 1 Elongation factor Tu GTP binding domain AAA_28 PF13521.1 AIC14558.1 - 0.0068 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain Miro PF08477.8 AIC14558.1 - 0.008 16.6 0.0 0.02 15.3 0.0 1.7 1 0 0 1 1 1 1 Miro-like protein ArgK PF03308.11 AIC14558.1 - 0.036 12.8 0.0 0.073 11.8 0.0 1.5 1 0 0 1 1 1 0 ArgK protein AAA_22 PF13401.1 AIC14558.1 - 0.038 14.1 0.0 0.15 12.2 0.0 2.0 2 1 0 3 3 2 0 AAA domain AAA_33 PF13671.1 AIC14558.1 - 0.053 13.4 0.0 0.1 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain MCM PF00493.18 AIC14558.1 - 0.055 12.2 0.0 0.092 11.5 0.0 1.3 1 0 0 1 1 1 0 MCM2/3/5 family 6PF2K PF01591.13 AIC14558.1 - 0.084 11.9 0.0 0.19 10.7 0.0 1.5 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_16 PF13191.1 AIC14558.1 - 0.12 12.2 0.2 0.29 11.1 0.0 1.6 1 1 1 2 2 2 0 AAA ATPase domain AAA_17 PF13207.1 AIC14558.1 - 0.14 12.9 0.1 0.49 11.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain Cupredoxin_1 PF13473.1 AIC14559.1 - 2e-09 37.3 0.0 2.2e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 AIC14559.1 - 0.015 15.5 0.6 0.03 14.5 0.4 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family COX2 PF00116.15 AIC14559.1 - 0.073 12.9 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, periplasmic domain HCV_NS4a PF01006.15 AIC14559.1 - 0.82 9.2 3.7 1.5 8.4 2.6 1.6 1 1 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a TRAM PF01938.15 AIC14560.1 - 8e-13 47.9 1.2 9.5e-13 47.7 0.8 1.1 1 0 0 1 1 1 1 TRAM domain DUF108 PF01958.13 AIC14561.1 - 8.6e-36 122.0 0.7 1.7e-35 121.1 0.5 1.5 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.11 AIC14561.1 - 2.5e-23 82.6 0.3 4e-23 82.0 0.2 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.17 AIC14561.1 - 2.4e-07 31.2 0.2 5.7e-07 30.0 0.1 1.7 1 1 1 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.15 AIC14561.1 - 1.8e-05 24.6 0.1 3.1e-05 23.9 0.1 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.19 AIC14561.1 - 2.2e-05 24.7 0.2 4.2e-05 23.8 0.2 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.10 AIC14561.1 - 2.7e-05 23.0 0.5 3.4e-05 22.7 0.3 1.3 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family NAD_Gly3P_dh_N PF01210.18 AIC14561.1 - 0.019 14.7 0.2 0.031 13.9 0.1 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus F420_oxidored PF03807.12 AIC14561.1 - 0.029 14.7 0.3 0.074 13.4 0.2 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 AIC14561.1 - 0.031 13.4 1.0 0.067 12.3 0.7 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 AIC14561.1 - 1.5 8.4 5.8 19 4.8 3.9 2.6 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ThiF PF00899.16 AIC14561.1 - 1.5 8.6 5.6 8.6 6.1 1.0 2.6 1 1 1 2 2 2 0 ThiF family Ribosomal_S30 PF04758.9 AIC14562.1 - 5.3e-09 35.6 5.7 6.9e-09 35.3 3.9 1.3 1 0 0 1 1 1 1 Ribosomal protein S30 NadA PF02445.11 AIC14565.1 - 6.1e-106 353.5 6.2 6.9e-106 353.3 4.3 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein Beta_propel PF09826.4 AIC14565.1 - 0.06 11.6 0.1 0.074 11.3 0.1 1.1 1 0 0 1 1 1 0 Beta propeller domain QRPTase_C PF01729.14 AIC14566.1 - 3.3e-52 176.4 0.4 5e-52 175.8 0.2 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.11 AIC14566.1 - 6.9e-26 89.8 0.2 1.2e-25 89.1 0.2 1.4 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Ribul_P_3_epim PF00834.14 AIC14566.1 - 0.019 14.0 0.1 0.055 12.5 0.0 1.8 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family Spt4 PF06093.8 AIC14567.1 - 1.6e-12 47.1 0.2 2e-12 46.7 0.1 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger RecR PF02132.10 AIC14567.1 - 0.001 18.4 0.7 0.0015 17.9 0.5 1.2 1 0 0 1 1 1 1 RecR protein Laminin_EGF PF00053.19 AIC14567.1 - 0.046 13.6 0.7 0.057 13.3 0.5 1.1 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) DZR PF12773.2 AIC14567.1 - 0.051 13.3 1.1 0.075 12.8 0.7 1.3 1 0 0 1 1 1 0 Double zinc ribbon TF_Zn_Ribbon PF08271.7 AIC14567.1 - 0.077 12.3 1.2 0.079 12.2 0.0 1.6 2 0 0 2 2 2 0 TFIIB zinc-binding SHS2_Rpb7-N PF03876.12 AIC14568.1 - 4.5e-18 65.1 0.0 6.7e-17 61.3 0.0 2.1 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.18 AIC14568.1 - 6.4e-14 51.7 0.1 1.2e-13 50.9 0.1 1.4 1 0 0 1 1 1 1 S1 RNA binding domain S1_2 PF13509.1 AIC14568.1 - 0.0025 17.6 0.0 0.0041 17.0 0.0 1.4 1 0 0 1 1 1 1 S1 domain ParA PF10609.4 AIC14569.1 - 1.4e-35 121.0 0.6 1.3e-34 117.9 0.2 2.2 2 0 0 2 2 2 1 ParA/MinD ATPase like CbiA PF01656.18 AIC14569.1 - 5.9e-21 74.7 0.0 9.7e-21 74.0 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain DUF59 PF01883.14 AIC14569.1 - 1.3e-20 73.1 0.1 3.5e-20 71.7 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function DUF59 AAA_31 PF13614.1 AIC14569.1 - 3.1e-11 43.4 0.1 1.9e-10 40.9 0.0 2.0 2 0 0 2 2 2 1 AAA domain MipZ PF09140.6 AIC14569.1 - 4.5e-07 29.2 0.0 9.7e-07 28.1 0.0 1.6 1 1 0 1 1 1 1 ATPase MipZ Fer4_NifH PF00142.13 AIC14569.1 - 1.7e-06 27.4 0.1 0.00083 18.6 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ArsA_ATPase PF02374.10 AIC14569.1 - 3.7e-06 26.2 1.2 3.7e-06 26.2 0.8 2.5 4 0 0 4 4 4 1 Anion-transporting ATPase VirC1 PF07015.6 AIC14569.1 - 0.00018 20.6 0.1 0.00033 19.8 0.0 1.3 1 0 0 1 1 1 1 VirC1 protein AAA_26 PF13500.1 AIC14569.1 - 0.00039 20.0 1.0 0.45 10.0 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 AIC14569.1 - 0.0043 16.4 0.1 0.0092 15.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.17 AIC14569.1 - 0.0062 15.9 0.1 0.013 14.9 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain APS_kinase PF01583.15 AIC14569.1 - 0.036 13.7 0.0 0.063 12.9 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase DUF258 PF03193.11 AIC14569.1 - 0.097 11.8 0.1 0.31 10.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_19 PF13245.1 AIC14569.1 - 1.2 8.9 3.8 1.2 8.9 0.7 2.2 2 0 0 2 2 2 0 Part of AAA domain DUF359 PF04019.7 AIC14570.1 - 4.4e-36 122.9 0.1 7.3e-36 122.2 0.0 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF359) HEM4 PF02602.10 AIC14570.1 - 0.041 13.1 0.2 0.1 11.8 0.1 1.6 1 1 1 2 2 2 0 Uroporphyrinogen-III synthase HemD DZR PF12773.2 AIC14571.1 - 0.055 13.2 1.5 0.055 13.2 1.0 1.3 1 1 1 2 2 2 0 Double zinc ribbon zf-CHY PF05495.7 AIC14571.1 - 0.091 12.9 5.0 0.2 11.8 1.5 1.9 1 1 1 2 2 2 0 CHY zinc finger zinc_ribbon_5 PF13719.1 AIC14571.1 - 0.1 12.2 0.8 0.73 9.4 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain DUF2318 PF10080.4 AIC14571.1 - 0.17 11.7 7.3 4.7 7.0 0.2 2.0 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) DUF4428 PF14471.1 AIC14571.1 - 0.33 10.7 6.2 1.5 8.6 4.2 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) zf-C2H2_jaz PF12171.3 AIC14571.1 - 1 9.5 4.0 0.96 9.6 0.4 2.1 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.10 AIC14571.1 - 2.5 7.9 5.2 3.6 7.4 0.2 2.1 1 1 1 2 2 2 0 BED zinc finger DUF329 PF03884.9 AIC14572.1 - 0.0044 16.5 8.8 0.15 11.6 0.6 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF329) Lar_restr_allev PF14354.1 AIC14572.1 - 0.012 15.8 13.2 0.97 9.7 0.1 3.1 2 1 1 3 3 3 0 Restriction alleviation protein Lar DnaJ_CXXCXGXG PF00684.14 AIC14572.1 - 0.015 15.3 11.8 0.13 12.3 7.8 2.2 1 1 0 1 1 1 0 DnaJ central domain zf-nanos PF05741.8 AIC14572.1 - 0.11 12.4 11.4 1.3 9.0 4.9 2.7 1 1 1 2 2 2 0 Nanos RNA binding domain Zn_Tnp_IS1595 PF12760.2 AIC14572.1 - 1.7 8.4 13.3 9 6.1 2.6 3.1 1 1 2 3 3 3 0 Transposase zinc-ribbon domain Rad50_zn_hook PF04423.9 AIC14572.1 - 2.5 7.6 5.5 17 4.9 0.2 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif Zn-ribbon_8 PF09723.5 AIC14572.1 - 8.4 6.4 13.4 12 5.9 0.3 3.3 2 1 1 3 3 3 0 Zinc ribbon domain zf-TFIIB PF13453.1 AIC14572.1 - 8.6 5.6 14.8 0.79 8.9 0.8 3.3 3 1 0 3 3 3 0 Transcription factor zinc-finger FAD-oxidase_C PF02913.14 AIC14573.1 - 1.7e-51 174.9 0.4 2.6e-51 174.3 0.3 1.3 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.18 AIC14573.1 - 1.3e-35 121.8 0.1 3.4e-35 120.5 0.0 1.8 1 0 0 1 1 1 1 FAD binding domain Methyltransf_23 PF13489.1 AIC14574.1 - 7.3e-15 55.0 0.0 1.3e-14 54.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC14574.1 - 1.2e-14 54.1 0.0 1.7e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14574.1 - 1.2e-13 51.3 0.0 2.2e-13 50.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC14574.1 - 1.1e-12 48.3 0.0 1.9e-12 47.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14574.1 - 1.1e-12 48.4 0.0 2.1e-12 47.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC14574.1 - 1.2e-10 41.6 0.0 2.1e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC14574.1 - 2.8e-09 36.4 0.0 5.5e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.13 AIC14574.1 - 4.8e-07 29.2 0.0 7.6e-07 28.5 0.0 1.5 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_26 PF13659.1 AIC14574.1 - 7.1e-07 29.2 0.1 2.1e-06 27.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 AIC14574.1 - 1.9e-06 27.3 0.0 2.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW MTS PF05175.9 AIC14574.1 - 7.2e-05 22.2 0.0 0.00016 21.0 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain NodS PF05401.6 AIC14574.1 - 8.3e-05 22.0 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_4 PF02390.12 AIC14574.1 - 0.0018 17.3 0.0 0.0053 15.8 0.0 1.7 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_9 PF08003.6 AIC14574.1 - 0.0031 16.2 0.0 0.0043 15.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) PCMT PF01135.14 AIC14574.1 - 0.024 14.1 0.0 0.035 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.15 AIC14574.1 - 0.029 13.4 0.0 0.038 13.0 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Glyoxalase_2 PF12681.2 AIC14575.1 - 5.6e-17 62.2 0.0 7e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 AIC14575.1 - 7.9e-14 51.7 0.0 1.1e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 AIC14575.1 - 0.0034 17.3 0.0 0.037 14.0 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SLT_2 PF13406.1 AIC14577.1 - 0.48 9.3 2.9 0.48 9.2 2.0 1.0 1 0 0 1 1 1 0 Transglycosylase SLT domain KIP1 PF07765.7 AIC14578.1 - 0.094 12.5 0.4 0.094 12.5 0.3 1.1 1 0 0 1 1 1 0 KIP1-like protein VIT1 PF01988.14 AIC14579.1 - 9.3e-66 221.3 4.4 1e-65 221.1 3.1 1.0 1 0 0 1 1 1 1 VIT family IncA PF04156.9 AIC14579.1 - 0.021 14.4 0.0 0.021 14.4 0.0 2.9 3 0 0 3 3 3 0 IncA protein DUF2842 PF11003.3 AIC14579.1 - 0.28 11.0 2.0 0.88 9.4 1.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2842) HTH_Tnp_ISL3 PF13542.1 AIC14580.1 - 0.0032 16.6 0.0 0.0042 16.2 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4_2 PF08281.7 AIC14580.1 - 0.052 13.0 0.0 0.063 12.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_23 PF13384.1 AIC14580.1 - 0.073 12.7 0.1 0.093 12.4 0.1 1.2 1 0 0 1 1 1 0 Homeodomain-like domain PCI PF01399.22 AIC14580.1 - 0.075 13.3 0.1 0.086 13.1 0.0 1.1 1 0 0 1 1 1 0 PCI domain DUF356 PF04009.7 AIC14580.1 - 0.1 12.7 0.1 0.1 12.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF356) Sigma70_r4 PF04545.11 AIC14580.1 - 0.14 11.4 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Sigma-70, region 4 COX1 PF00115.15 AIC14581.1 - 0.0026 16.4 14.9 0.0026 16.4 10.3 1.8 1 1 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF4231 PF14015.1 AIC14581.1 - 0.071 13.1 0.5 0.071 13.1 0.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DUF4271 PF14093.1 AIC14581.1 - 0.19 11.4 3.2 0.41 10.2 2.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) DUF3112 PF11309.3 AIC14581.1 - 0.24 11.1 3.9 0.15 11.8 0.6 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3112) TrbI PF03743.9 AIC14581.1 - 0.4 10.1 2.8 4.6 6.6 0.1 2.2 2 0 0 2 2 2 0 Bacterial conjugation TrbI-like protein Pox_A14 PF05767.7 AIC14581.1 - 0.69 9.9 3.7 0.26 11.2 0.5 1.8 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 RseC_MucC PF04246.7 AIC14581.1 - 4.7 6.7 8.1 0.85 9.1 0.7 2.5 2 2 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC HSP20 PF00011.16 AIC14583.1 - 6.1e-23 80.6 4.4 9e-23 80.0 3.1 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family P-II PF00543.17 AIC14585.1 - 7.8e-13 48.7 0.0 9e-13 48.5 0.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II DUF4322 PF14210.1 AIC14585.1 - 0.061 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4322) DUF1861 PF08950.5 AIC14586.1 - 0.018 13.8 0.1 0.02 13.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1861) GerPC PF10737.4 AIC14586.1 - 0.042 13.6 2.4 4.5 7.0 0.1 2.1 2 0 0 2 2 2 0 Spore germination protein GerPC PSS PF03034.10 AIC14586.1 - 0.14 11.5 0.8 0.39 10.0 0.0 1.9 2 1 0 2 2 2 0 Phosphatidyl serine synthase CBS PF00571.23 AIC14587.1 - 6e-24 83.5 0.6 9.9e-13 47.6 0.0 2.5 2 1 0 2 2 2 2 CBS domain Ribosomal_L9_C PF03948.9 AIC14587.1 - 0.042 13.9 0.8 2.6 8.1 0.1 2.3 1 1 1 2 2 2 0 Ribosomal protein L9, C-terminal domain PcrB PF01884.12 AIC14587.1 - 0.077 12.2 0.8 0.2 10.8 0.6 1.7 1 1 0 1 1 1 0 PcrB family Antimicrobial20 PF08256.6 AIC14587.1 - 1.3 9.5 4.5 41 4.9 0.1 3.2 2 0 0 2 2 2 0 Aurein-like antibiotic peptide Usp PF00582.21 AIC14589.1 - 7.2e-28 97.5 0.3 8.7e-28 97.2 0.2 1.1 1 0 0 1 1 1 1 Universal stress protein family PcrB PF01884.12 AIC14589.1 - 0.038 13.2 0.2 0.056 12.6 0.1 1.4 1 0 0 1 1 1 0 PcrB family DUF900 PF05990.7 AIC14589.1 - 0.12 11.7 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) SnoaL_2 PF12680.2 AIC14590.1 - 0.00023 21.5 0.0 0.00036 20.9 0.0 1.4 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 AIC14590.1 - 0.0043 17.2 0.0 0.0053 16.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.1 AIC14590.1 - 0.0049 16.7 0.1 0.014 15.3 0.0 1.6 1 1 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.5 AIC14590.1 - 0.019 14.8 0.0 0.023 14.5 0.0 1.2 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II Association Lumazine_bd PF12870.2 AIC14590.1 - 0.047 13.7 0.0 0.087 12.8 0.0 1.4 1 1 0 1 1 1 0 Lumazine-binding domain NTF2 PF02136.15 AIC14590.1 - 0.086 13.2 0.0 0.12 12.7 0.0 1.3 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain SnoaL_3 PF13474.1 AIC14590.1 - 0.093 12.7 0.0 0.13 12.2 0.0 1.4 1 1 0 1 1 1 0 SnoaL-like domain DUF4415 PF14384.1 AIC14591.1 - 0.01 15.9 0.0 0.03 14.4 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4415) HicB PF05534.7 AIC14591.1 - 0.02 14.4 0.0 0.038 13.5 0.0 1.5 1 0 0 1 1 1 0 HicB family Usp PF00582.21 AIC14592.1 - 1e-29 103.5 0.8 1.2e-29 103.2 0.6 1.1 1 0 0 1 1 1 1 Universal stress protein family CBS PF00571.23 AIC14593.1 - 1.4e-24 85.5 2.1 5.1e-12 45.3 0.1 2.2 2 0 0 2 2 2 2 CBS domain zf-Di19 PF05605.7 AIC14593.1 - 0.00029 20.9 0.0 0.00053 20.0 0.0 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 AIC14593.1 - 0.00033 20.7 0.3 0.00081 19.5 0.1 1.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC14593.1 - 0.00044 20.4 0.3 0.0036 17.5 0.1 2.3 2 0 0 2 2 2 1 Zinc finger, C2H2 type UPF0081 PF03652.10 AIC14593.1 - 0.02 15.0 0.1 0.03 14.4 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0081) zf-RING_3 PF14369.1 AIC14593.1 - 0.056 13.4 0.2 0.097 12.6 0.1 1.3 1 0 0 1 1 1 0 zinc-finger THF_DHG_CYH_C PF02882.14 AIC14593.1 - 0.059 12.4 0.1 0.097 11.7 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Thioredoxin_2 PF13098.1 AIC14593.1 - 0.1 12.8 0.1 2.1 8.5 0.0 2.6 3 0 0 3 3 3 0 Thioredoxin-like domain BIR PF00653.16 AIC14593.1 - 0.13 12.7 0.0 0.26 11.7 0.0 1.4 1 0 0 1 1 1 0 Inhibitor of Apoptosis domain Cys_rich_CPXG PF14255.1 AIC14593.1 - 0.15 11.8 0.1 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 Cysteine-rich CPXCG CBS PF00571.23 AIC14594.1 - 2.7e-32 110.2 2.5 1.8e-16 59.6 0.1 2.2 2 0 0 2 2 2 2 CBS domain SAF_2 PF13144.1 AIC14594.1 - 0.0011 18.4 0.7 0.0014 18.1 0.5 1.2 1 0 0 1 1 1 1 SAF-like NIR_SIR_ferr PF03460.12 AIC14594.1 - 0.14 11.8 0.2 0.53 9.9 0.0 2.0 2 1 0 2 2 2 0 Nitrite/Sulfite reductase ferredoxin-like half domain Usp PF00582.21 AIC14595.1 - 1.1e-23 84.0 0.1 1.1e-23 84.0 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family AA_permease_2 PF13520.1 AIC14596.1 - 1.3e-53 182.0 60.2 1.6e-53 181.7 41.8 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AIC14596.1 - 2e-34 118.7 57.2 2.6e-34 118.4 39.7 1.0 1 0 0 1 1 1 1 Amino acid permease Sigma70_ECF PF07638.6 AIC14598.1 - 2e-05 24.3 0.0 2.1e-05 24.2 0.0 1.0 1 0 0 1 1 1 1 ECF sigma factor HTH_7 PF02796.10 AIC14598.1 - 0.00016 21.4 0.0 0.00017 21.3 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase Sigma70_r4_2 PF08281.7 AIC14598.1 - 0.00023 20.5 0.0 0.0003 20.1 0.0 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_23 PF13384.1 AIC14598.1 - 0.00026 20.5 0.1 0.00035 20.1 0.1 1.1 1 0 0 1 1 1 1 Homeodomain-like domain GerE PF00196.14 AIC14598.1 - 0.00064 18.9 0.0 0.00084 18.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_Tnp_ISL3 PF13542.1 AIC14598.1 - 0.0048 16.0 0.0 0.0081 15.3 0.0 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_28 PF13518.1 AIC14598.1 - 0.0059 16.5 0.0 0.0076 16.2 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4 PF04545.11 AIC14598.1 - 0.0087 15.3 0.1 0.011 14.9 0.1 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_38 PF13936.1 AIC14598.1 - 0.0097 15.4 0.3 0.013 15.0 0.2 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.1 AIC14598.1 - 0.026 13.9 0.1 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Terminase_5 PF06056.7 AIC14598.1 - 0.027 14.0 0.0 0.038 13.5 0.0 1.2 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Rrf2 PF02082.15 AIC14598.1 - 0.044 13.8 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator CBS PF00571.23 AIC14599.1 - 1.1e-14 53.8 0.1 1.8e-05 24.4 0.0 3.6 3 0 0 3 3 3 3 CBS domain ADH_zinc_N PF00107.21 AIC14600.1 - 8.7e-32 109.3 0.1 1.6e-31 108.5 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AIC14600.1 - 7.1e-28 96.5 0.2 1.4e-27 95.5 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 AIC14600.1 - 1.9e-15 57.8 0.0 3.6e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 AIC14600.1 - 0.0076 16.2 0.1 0.014 15.4 0.1 1.4 1 0 0 1 1 1 1 TrkA-N domain Methyltransf_31 PF13847.1 AIC14600.1 - 0.027 14.0 0.1 0.11 12.0 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14600.1 - 0.13 12.8 0.0 0.37 11.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Clp_N PF02861.15 AIC14601.1 - 0.094 12.6 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Clp amino terminal domain Usp PF00582.21 AIC14602.1 - 9.8e-16 58.2 0.5 1.1e-15 58.0 0.4 1.0 1 0 0 1 1 1 1 Universal stress protein family SRP54 PF00448.17 AIC14602.1 - 0.015 14.7 0.1 0.015 14.7 0.1 1.0 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Usp PF00582.21 AIC14603.1 - 6.5e-08 32.8 0.0 7e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family CBS PF00571.23 AIC14604.1 - 1.5e-39 133.5 5.4 4.8e-12 45.4 0.1 4.1 4 0 0 4 4 4 4 CBS domain Usp PF00582.21 AIC14605.1 - 8.3e-26 90.8 0.6 8.1e-25 87.6 0.4 2.0 1 1 0 1 1 1 1 Universal stress protein family DXP_reductoisom PF02670.11 AIC14605.1 - 0.031 14.8 0.0 0.043 14.3 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Usp PF00582.21 AIC14606.1 - 3.2e-29 101.9 0.0 4.9e-29 101.3 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family Paramyxo_NS_C PF02725.9 AIC14606.1 - 0.057 13.0 0.3 0.12 11.9 0.0 1.5 2 0 0 2 2 2 0 Non-structural protein C DUF1469 PF07332.6 AIC14607.1 - 0.0016 18.1 6.0 0.0018 17.9 4.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1469) HAMP PF00672.20 AIC14607.1 - 0.65 10.2 3.6 2 8.6 0.0 2.1 1 1 1 2 2 2 0 HAMP domain DUF202 PF02656.10 AIC14607.1 - 2.1 8.6 7.1 6.2 7.1 4.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF3143 PF11341.3 AIC14608.1 - 0.005 16.6 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3143) RDD PF06271.7 AIC14609.1 - 7.3e-17 61.5 3.3 9e-17 61.2 2.3 1.1 1 0 0 1 1 1 1 RDD family DUF4232 PF14016.1 AIC14610.1 - 0.023 14.3 0.0 0.042 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4232) Filamin PF00630.14 AIC14610.1 - 0.037 14.5 0.0 0.058 13.9 0.0 1.3 1 0 0 1 1 1 0 Filamin/ABP280 repeat CarboxypepD_reg PF13620.1 AIC14610.1 - 0.056 13.4 4.5 1.1 9.3 0.6 3.3 2 1 0 2 2 2 0 Carboxypeptidase regulatory-like domain DUF11 PF01345.13 AIC14610.1 - 0.078 13.0 1.0 0.19 11.7 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF11 DUF2371 PF10177.4 AIC14610.1 - 0.12 12.2 1.5 7.2 6.4 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) EMP24_GP25L PF01105.19 AIC14610.1 - 0.14 11.8 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF3040 PF11239.3 AIC14610.1 - 0.3 11.1 8.2 0.25 11.4 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Big_3 PF07523.7 AIC14610.1 - 0.58 10.2 3.6 0.44 10.6 0.1 2.5 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) PIRT PF15099.1 AIC14610.1 - 0.67 9.1 3.4 8.2 5.6 0.2 2.4 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family Flavodoxin_1 PF00258.20 AIC14611.1 - 5.1e-10 39.5 0.1 7.6e-10 38.9 0.1 1.5 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_3 PF12641.2 AIC14611.1 - 1.5e-07 31.0 0.0 2.3e-07 30.3 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_5 PF12724.2 AIC14611.1 - 6.3e-07 29.4 0.0 9.2e-07 28.9 0.0 1.3 1 1 0 1 1 1 1 Flavodoxin domain Flavodoxin_4 PF12682.2 AIC14611.1 - 0.00051 19.4 0.0 0.0081 15.5 0.0 2.1 1 1 1 2 2 2 1 Flavodoxin FMN_red PF03358.10 AIC14611.1 - 0.00076 19.0 0.0 0.52 9.8 0.0 2.2 1 1 1 2 2 2 2 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 AIC14611.1 - 0.0015 18.1 0.0 0.0085 15.6 0.0 2.0 1 1 0 1 1 1 1 Flavodoxin-like fold PTS_IIB PF02302.12 AIC14611.1 - 0.06 13.8 0.5 0.42 11.1 0.0 2.2 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit Syd PF07348.7 AIC14611.1 - 0.065 12.5 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 Syd protein (SUKH-2) ABC_membrane_3 PF13748.1 AIC14612.1 - 0.76 8.7 4.1 0.13 11.2 0.4 1.4 2 0 0 2 2 2 0 ABC transporter transmembrane region Cupredoxin_1 PF13473.1 AIC14613.1 - 0.00059 19.6 0.0 0.0015 18.4 0.0 1.7 1 1 1 2 2 2 1 Cupredoxin-like domain Molybdop_Fe4S4 PF04879.11 AIC14614.1 - 0.4 10.5 3.1 0.37 10.6 0.2 2.2 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain Methyltransf_31 PF13847.1 AIC14615.1 - 5.4e-18 65.0 0.0 8.4e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14615.1 - 3.4e-15 56.2 0.0 6.9e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14615.1 - 1.9e-12 47.7 0.1 3.7e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC14615.1 - 1.2e-10 41.3 0.0 1.9e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC14615.1 - 2.1e-09 36.8 0.0 7.6e-08 31.7 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.7 AIC14615.1 - 2.2e-09 37.6 0.0 4.4e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC14615.1 - 9.7e-09 35.5 0.0 1.7e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC14615.1 - 2.5e-06 27.4 0.5 9.6e-06 25.6 0.3 1.9 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 AIC14615.1 - 0.00064 19.1 0.0 0.0012 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 AIC14615.1 - 0.011 14.8 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.13 AIC14615.1 - 0.021 14.4 0.0 0.037 13.6 0.0 1.4 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Cons_hypoth95 PF03602.10 AIC14615.1 - 0.035 13.5 0.2 0.08 12.3 0.1 1.6 2 0 0 2 2 2 0 Conserved hypothetical protein 95 PCMT PF01135.14 AIC14615.1 - 0.068 12.6 0.1 0.18 11.2 0.0 1.8 2 1 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-C2H2 PF00096.21 AIC14616.1 - 0.00012 22.2 0.4 0.00012 22.2 0.2 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-Di19 PF05605.7 AIC14616.1 - 0.0068 16.4 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.1 AIC14616.1 - 0.0075 16.5 0.1 0.0075 16.5 0.1 2.0 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AIC14616.1 - 0.0088 15.9 0.6 0.034 14.0 0.4 2.1 1 1 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AIC14616.1 - 0.03 14.6 1.0 2.5 8.5 0.0 2.5 2 1 0 2 2 2 0 Zinc-finger double domain zf-met2 PF12907.2 AIC14616.1 - 0.051 13.5 0.5 0.11 12.5 0.4 1.6 1 1 0 1 1 1 0 Zinc-binding zf-C2H2_2 PF12756.2 AIC14616.1 - 0.12 12.4 0.1 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.3 AIC14616.1 - 0.41 10.8 9.0 0.51 10.5 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding DUF4064 PF13273.1 AIC14618.1 - 0.00045 20.2 0.1 0.00052 20.0 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) DUF1218 PF06749.7 AIC14618.1 - 0.02 15.3 1.0 0.029 14.8 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1218) BPD_transp_2 PF02653.11 AIC14618.1 - 0.027 13.4 0.3 0.031 13.2 0.2 1.0 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component DUF2189 PF09955.4 AIC14618.1 - 0.032 14.1 1.4 0.039 13.8 0.9 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2189) Claudin_2 PF13903.1 AIC14618.1 - 0.056 13.1 6.5 0.11 12.2 0.1 2.0 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction Cytochrom_B_C PF00032.12 AIC14618.1 - 0.12 12.5 0.1 0.16 12.2 0.1 1.2 1 0 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD DUF202 PF02656.10 AIC14618.1 - 0.3 11.3 4.3 0.74 10.0 3.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF202) P12 PF12669.2 AIC14618.1 - 0.84 9.8 6.0 7.7 6.8 0.1 2.4 2 1 0 2 2 2 0 Virus attachment protein p12 family DUF2976 PF11190.3 AIC14618.1 - 1.7 8.2 4.4 0.68 9.4 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2976) Pyridox_oxidase PF01243.15 AIC14619.1 - 5.9e-19 67.8 0.0 7.8e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 AIC14619.1 - 1.6e-13 50.6 0.0 2e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase MtrA PF04208.9 AIC14620.1 - 6.9e-29 100.5 0.0 8.9e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit A dUTPase_2 PF08761.6 AIC14621.1 - 1.2e-19 70.9 1.9 2.5e-13 50.4 0.1 2.0 1 1 1 2 2 2 2 dUTPase DUF550 PF04447.7 AIC14621.1 - 0.00091 18.7 0.6 0.0016 18.0 0.0 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF550) PRA-PH PF01503.12 AIC14621.1 - 0.096 12.9 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl-ATP pyrophosphohydrolase OMS28_porin PF03532.8 AIC14622.1 - 0.00069 18.7 0.0 0.0011 18.0 0.0 1.3 1 0 0 1 1 1 1 OMS28 porin Glycos_transf_2 PF00535.21 AIC14623.1 - 9.1e-36 123.0 0.0 1.5e-35 122.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 GtrA PF04138.9 AIC14623.1 - 9.4e-22 77.1 12.9 1.5e-13 50.7 6.3 2.2 1 1 1 2 2 2 2 GtrA-like protein Glyco_tranf_2_3 PF13641.1 AIC14623.1 - 8.5e-17 61.7 0.0 1.4e-16 61.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 NTP_transf_3 PF12804.2 AIC14623.1 - 8.7e-07 29.1 0.0 1.4e-06 28.4 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glyco_tranf_2_2 PF10111.4 AIC14623.1 - 0.0021 17.2 0.0 0.0081 15.2 0.0 1.9 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 AIC14623.1 - 0.0024 17.1 0.0 0.0046 16.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Amidohydro_4 PF13147.1 AIC14623.1 - 0.089 12.8 0.2 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 Amidohydrolase Glyco_tranf_2_4 PF13704.1 AIC14623.1 - 0.14 12.4 0.0 0.24 11.7 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 Rad51 PF08423.6 AIC14624.1 - 1e-30 106.5 0.1 1.1e-30 106.3 0.1 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 AIC14624.1 - 1.9e-10 40.4 0.3 4.3e-10 39.3 0.2 1.6 1 1 0 1 1 1 1 AAA domain RecA PF00154.16 AIC14624.1 - 9.7e-08 31.4 0.1 9.7e-08 31.4 0.1 1.3 1 1 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 AIC14624.1 - 1e-05 24.7 0.3 3.1e-05 23.2 0.2 1.9 1 1 0 1 1 1 1 KaiC AAA_22 PF13401.1 AIC14624.1 - 0.0016 18.5 0.0 0.0049 17.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain CbiA PF01656.18 AIC14624.1 - 0.0026 17.1 0.0 0.0066 15.8 0.0 1.6 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Arch_ATPase PF01637.13 AIC14624.1 - 0.025 14.2 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase TrwB_AAD_bind PF10412.4 AIC14624.1 - 0.027 13.1 0.1 0.071 11.7 0.0 1.6 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_10 PF12846.2 AIC14624.1 - 0.03 13.7 0.0 0.041 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain IstB_IS21 PF01695.12 AIC14624.1 - 0.033 13.5 0.2 0.15 11.4 0.1 2.0 1 1 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.17 AIC14624.1 - 0.05 13.7 0.0 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 RNA helicase MobB PF03205.9 AIC14624.1 - 0.12 12.1 0.0 0.33 10.6 0.0 1.7 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B ICAP-1_inte_bdg PF10480.4 AIC14624.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Beta-1 integrin binding protein LSM PF01423.17 AIC14625.1 - 2.6e-17 62.1 0.8 2.9e-17 61.9 0.6 1.0 1 0 0 1 1 1 1 LSM domain DUF1161 PF06649.7 AIC14625.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1161) S-AdoMet_synt_C PF02773.11 AIC14626.1 - 1.7e-69 231.8 0.2 2.8e-69 231.1 0.1 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.11 AIC14626.1 - 6.7e-50 168.0 0.0 2e-49 166.4 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.15 AIC14626.1 - 2.3e-43 146.4 0.2 5.7e-43 145.2 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain adh_short PF00106.20 AIC14627.1 - 6.4e-31 107.5 0.1 9.8e-31 106.9 0.1 1.3 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AIC14627.1 - 3.1e-25 89.3 0.1 3.8e-25 89.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AIC14627.1 - 2.6e-13 50.0 0.1 4.7e-13 49.2 0.1 1.4 1 0 0 1 1 1 1 KR domain Epimerase PF01370.16 AIC14627.1 - 3.9e-06 26.4 0.1 1.5e-05 24.5 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 AIC14627.1 - 1e-05 25.6 0.2 2.4e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 NADH(P)-binding Saccharop_dh PF03435.13 AIC14627.1 - 0.0012 17.8 0.0 0.0039 16.2 0.0 1.7 2 0 0 2 2 2 1 Saccharopine dehydrogenase RmlD_sub_bind PF04321.12 AIC14627.1 - 0.0013 17.6 0.0 0.0021 17.0 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain F420_oxidored PF03807.12 AIC14627.1 - 0.0044 17.4 0.1 0.011 16.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Glyco_transf_4 PF13439.1 AIC14627.1 - 0.082 12.6 0.0 0.18 11.5 0.0 1.6 1 1 0 1 1 1 0 Glycosyltransferase Family 4 THF_DHG_CYH_C PF02882.14 AIC14627.1 - 0.094 11.7 0.1 0.26 10.3 0.0 1.7 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CbiD PF01888.12 AIC14628.1 - 3e-84 282.0 4.9 4.2e-84 281.5 3.4 1.2 1 0 0 1 1 1 1 CbiD HTH_AsnC-type PF13404.1 AIC14629.1 - 6.1e-14 51.2 0.1 1.3e-13 50.2 0.0 1.6 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 AIC14629.1 - 2.1e-11 43.0 0.0 3e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Arc_trans_TRASH PF08394.5 AIC14629.1 - 5.5e-06 26.4 2.7 9.4e-06 25.6 1.9 1.4 1 0 0 1 1 1 1 Archaeal TRASH domain TrmB PF01978.14 AIC14629.1 - 8e-06 25.4 0.1 2.9e-05 23.6 0.1 1.9 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Tnp_ISL3 PF13542.1 AIC14629.1 - 0.0023 17.0 0.0 0.0034 16.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 HTH_5 PF01022.15 AIC14629.1 - 0.0042 16.7 0.0 0.0062 16.1 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF2089 PF09862.4 AIC14629.1 - 0.0059 16.3 0.1 0.14 11.9 0.0 2.2 1 1 0 2 2 2 1 Protein of unknown function (DUF2089) zf-FCS PF06467.9 AIC14629.1 - 0.011 15.3 4.8 0.029 14.0 3.3 1.7 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif HTH_28 PF13518.1 AIC14629.1 - 0.016 15.1 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2250 PF10007.4 AIC14629.1 - 0.022 14.6 0.1 0.036 13.9 0.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) Sialidase PF02973.11 AIC14629.1 - 0.081 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 Sialidase, N-terminal domain HTH_IclR PF09339.5 AIC14629.1 - 0.082 12.5 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 IclR helix-turn-helix domain ATPase-cat_bd PF12156.3 AIC14629.1 - 0.15 12.6 1.6 0.34 11.4 1.1 1.6 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase zf-H2C2_2 PF13465.1 AIC14629.1 - 6.7 7.2 7.6 13 6.3 0.9 2.4 2 0 0 2 2 2 0 Zinc-finger double domain PMT_2 PF13231.1 AIC14630.1 - 6.5e-10 39.1 14.9 6.5e-10 39.1 10.3 2.6 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase PMT PF02366.13 AIC14630.1 - 1.3e-08 34.5 17.0 2e-08 33.8 10.1 2.3 1 1 0 1 1 1 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Glyco_transf_22 PF03901.12 AIC14630.1 - 2e-07 30.3 3.1 2e-07 30.3 2.2 2.4 2 1 0 2 2 2 1 Alg9-like mannosyltransferase family CbiG_N PF11760.3 AIC14631.1 - 6.5e-32 109.0 0.2 1.3e-31 108.1 0.1 1.5 1 0 0 1 1 1 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.11 AIC14631.1 - 1.9e-30 105.5 0.0 3.9e-30 104.5 0.0 1.5 1 0 0 1 1 1 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.3 AIC14631.1 - 6e-13 48.8 0.0 3e-12 46.6 0.0 2.2 2 0 0 2 2 2 1 Cobalamin biosynthesis central region CbiC PF02570.10 AIC14632.1 - 1.1e-73 246.8 0.2 2e-73 246.0 0.1 1.4 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.12 AIC14632.1 - 1.3e-34 118.4 0.0 1.8e-16 60.1 0.1 2.3 2 0 0 2 2 2 2 CbiX CbiK PF06180.6 AIC14632.1 - 4.2e-10 39.1 0.0 6.4e-10 38.5 0.0 1.2 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) TPP_enzyme_M PF00205.17 AIC14632.1 - 0.0026 17.5 0.1 4.5 7.0 0.0 3.5 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, central domain Ferrochelatase PF00762.14 AIC14632.1 - 0.021 13.8 0.0 0.55 9.1 0.0 2.4 2 1 1 3 3 3 0 Ferrochelatase GATase_3 PF07685.9 AIC14633.1 - 7.2e-29 100.4 0.1 1.2e-28 99.7 0.0 1.3 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain CbiA PF01656.18 AIC14633.1 - 5.9e-24 84.5 0.1 1.2e-23 83.5 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.1 AIC14633.1 - 1.4e-15 57.4 2.2 9.4e-10 38.4 0.0 3.0 1 1 1 3 3 3 2 AAA domain SNO PF01174.14 AIC14633.1 - 0.016 14.8 0.0 0.037 13.6 0.0 1.5 1 0 0 1 1 1 0 SNO glutamine amidotransferase family AAA_17 PF13207.1 AIC14633.1 - 0.074 13.8 0.9 0.29 11.9 0.3 2.2 1 1 0 1 1 1 0 AAA domain AAA_31 PF13614.1 AIC14633.1 - 0.093 12.6 0.1 0.26 11.1 0.1 1.7 1 0 0 1 1 1 0 AAA domain CTP_synth_N PF06418.9 AIC14633.1 - 0.099 11.7 0.0 0.16 10.9 0.0 1.2 1 0 0 1 1 1 0 CTP synthase N-terminus GATase PF00117.23 AIC14633.1 - 0.15 11.5 0.0 1.4 8.3 0.0 2.1 2 0 0 2 2 2 0 Glutamine amidotransferase class-I AAA_18 PF13238.1 AIC14633.1 - 0.16 12.3 0.0 0.51 10.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain bPH_3 PF14470.1 AIC14634.1 - 2.2e-09 37.4 0.0 3.4e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial PH domain DZR PF12773.2 AIC14634.1 - 2.5e-09 36.7 9.8 5.8e-09 35.6 6.8 1.6 1 1 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC14634.1 - 4.2e-09 35.3 9.3 6.1e-05 22.0 1.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain SHOCT PF09851.4 AIC14634.1 - 0.00067 19.0 1.3 0.0013 18.0 0.9 1.5 1 0 0 1 1 1 1 Short C-terminal domain zf-DHHC PF01529.15 AIC14634.1 - 0.0011 18.3 4.4 0.056 12.8 0.1 2.1 1 1 1 2 2 2 2 DHHC palmitoyltransferase UPF0547 PF10571.4 AIC14634.1 - 0.0028 17.3 12.6 0.0068 16.0 0.1 3.3 2 1 1 3 3 3 2 Uncharacterised protein family UPF0547 NOB1_Zn_bind PF08772.6 AIC14634.1 - 0.003 17.3 11.1 0.011 15.4 0.7 2.4 1 1 1 2 2 2 2 Nin one binding (NOB1) Zn-ribbon like zinc-ribbons_6 PF07191.7 AIC14634.1 - 0.0035 17.0 8.1 0.29 10.9 0.5 2.3 2 0 0 2 2 2 2 zinc-ribbons zinc_ribbon_2 PF13240.1 AIC14634.1 - 0.015 14.7 12.5 0.022 14.2 1.0 3.1 1 1 3 4 4 4 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.8 AIC14634.1 - 0.79 9.2 0.0 0.79 9.2 0.0 3.4 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit RNA_POL_M_15KD PF02150.11 AIC14634.1 - 1.9 8.2 12.4 59 3.4 6.0 3.3 2 1 0 2 2 2 0 RNA polymerases M/15 Kd subunit Prok-RING_1 PF14446.1 AIC14634.1 - 2.7 7.7 10.3 2.2 8.0 1.4 3.0 2 1 1 3 3 3 0 Prokaryotic RING finger family 1 OrfB_Zn_ribbon PF07282.6 AIC14634.1 - 5.6 6.6 7.0 1.7 8.3 0.9 2.5 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-BED PF02892.10 AIC14634.1 - 6.2 6.6 5.7 3 7.6 0.0 2.5 2 1 1 3 3 3 0 BED zinc finger CobA_CobO_BtuR PF02572.10 AIC14635.1 - 1.6e-62 210.1 1.2 1.8e-62 209.9 0.8 1.0 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP IstB_IS21 PF01695.12 AIC14635.1 - 0.0004 19.8 2.7 0.26 10.6 0.0 2.1 1 1 1 2 2 2 2 IstB-like ATP binding protein AAA_22 PF13401.1 AIC14635.1 - 0.05 13.7 1.4 0.14 12.2 1.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.1 AIC14635.1 - 0.078 12.7 1.5 0.13 12.0 0.3 1.8 2 0 0 2 2 2 0 Part of AAA domain DUF2067 PF09840.4 AIC14635.1 - 0.088 12.3 0.5 0.11 11.9 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2067) EIF_2_alpha PF07541.7 AIC14636.1 - 1.9e-22 79.1 2.7 2.1e-22 78.9 0.3 2.3 2 1 1 3 3 3 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.18 AIC14636.1 - 6e-14 51.9 0.4 2.1e-13 50.1 0.0 2.1 2 0 0 2 2 2 1 S1 RNA binding domain MBT PF02820.13 AIC14636.1 - 0.033 14.0 0.0 0.067 13.1 0.0 1.5 1 0 0 1 1 1 0 mbt repeat Nop10p PF04135.7 AIC14637.1 - 1.3e-22 79.3 2.5 1.4e-22 79.1 1.7 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family NOB1_Zn_bind PF08772.6 AIC14637.1 - 0.014 15.2 0.2 0.016 15.0 0.1 1.3 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like RecR PF02132.10 AIC14637.1 - 0.015 14.7 0.8 0.02 14.3 0.5 1.3 1 0 0 1 1 1 0 RecR protein DZR PF12773.2 AIC14637.1 - 0.016 15.0 1.2 0.023 14.5 0.8 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC14637.1 - 0.026 13.7 5.8 0.35 10.1 3.6 2.2 1 1 1 2 2 2 0 zinc-ribbon domain PolC_DP2 PF03833.8 AIC14637.1 - 0.047 11.3 0.3 0.043 11.4 0.2 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zinc_ribbon_2 PF13240.1 AIC14637.1 - 0.085 12.3 3.8 0.9 9.1 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-tcix PF14952.1 AIC14637.1 - 0.34 10.2 7.6 2.4 7.5 4.8 2.0 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding DUF35_N PF12172.3 AIC14637.1 - 1.3 9.0 5.1 2.7 8.0 2.5 2.1 1 1 1 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-CCHC_6 PF15288.1 AIC14637.1 - 3.1 7.5 7.9 5.2 6.8 0.6 2.3 2 0 0 2 2 2 0 Zinc knuckle Trp_halogenase PF04820.9 AIC14638.1 - 0.023 13.3 0.0 0.043 12.4 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase 4HBT PF03061.17 AIC14639.1 - 1.7e-17 63.3 0.4 2.3e-17 62.8 0.3 1.2 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.14 AIC14639.1 - 0.0019 17.5 0.1 0.0031 16.8 0.1 1.3 1 0 0 1 1 1 1 MaoC like domain DUF4442 PF14539.1 AIC14639.1 - 0.02 14.8 0.9 0.14 12.1 0.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4442) RNA_pol_3_Rpc31 PF11705.3 AIC14640.1 - 0.24 11.2 3.5 0.26 11.1 2.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PEP_mutase PF13714.1 AIC14641.1 - 6.1e-59 199.1 0.0 7.1e-59 198.9 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.16 AIC14641.1 - 1.5e-15 56.4 0.0 4.3e-14 51.6 0.0 2.4 1 1 1 2 2 2 2 Isocitrate lyase family Glyoxalase_2 PF12681.2 AIC14642.1 - 4.5e-15 56.1 0.0 5.3e-15 55.9 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 AIC14642.1 - 1.1e-10 41.5 0.0 1.9e-10 40.8 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 AIC14642.1 - 0.094 12.7 0.0 0.16 12.0 0.0 1.4 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TFIIS_C PF01096.13 AIC14643.1 - 0.0015 18.0 1.1 0.051 13.2 0.2 2.1 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) SspK PF08176.7 AIC14643.1 - 0.021 14.8 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Small acid-soluble spore protein K family DZR PF12773.2 AIC14643.1 - 0.029 14.1 0.2 0.046 13.5 0.1 1.4 1 1 0 1 1 1 0 Double zinc ribbon RNA_POL_M_15KD PF02150.11 AIC14643.1 - 0.031 13.9 2.1 0.15 11.7 1.5 1.9 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit Lar_restr_allev PF14354.1 AIC14643.1 - 0.033 14.4 0.4 0.043 14.1 0.3 1.3 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF3797 PF12677.2 AIC14643.1 - 0.046 13.3 0.1 7.3 6.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) Zn_Tnp_IS1595 PF12760.2 AIC14643.1 - 0.046 13.5 0.7 0.082 12.7 0.5 1.4 1 1 0 1 1 1 0 Transposase zinc-ribbon domain DNA_ligase_ZBD PF03119.11 AIC14643.1 - 0.069 12.8 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain DUF3268 PF11672.3 AIC14643.1 - 0.07 13.2 0.1 0.072 13.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3268) Zn-ribbon_8 PF09723.5 AIC14643.1 - 0.083 12.8 0.7 5.5 7.0 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain DUF2757 PF10955.3 AIC14643.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2757) zinc-ribbons_6 PF07191.7 AIC14643.1 - 0.14 11.9 0.5 0.31 10.8 0.3 1.6 1 1 0 1 1 1 0 zinc-ribbons DUF329 PF03884.9 AIC14643.1 - 0.24 10.9 1.4 1.2 8.7 0.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF329) zf-H2C2_2 PF13465.1 AIC14643.1 - 0.47 10.8 3.6 2.1 8.8 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger double domain zf-IS66 PF13005.2 AIC14643.1 - 1.9 8.4 6.4 2.1 8.4 0.2 2.2 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 Rubredoxin PF00301.15 AIC14643.1 - 5.9 6.8 5.7 11 6.0 0.4 2.3 1 1 0 2 2 2 0 Rubredoxin HTH_24 PF13412.1 AIC14644.1 - 8.2e-09 34.7 0.1 1.4e-08 33.9 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC14644.1 - 7.5e-05 22.1 0.3 0.00014 21.3 0.2 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.2 AIC14644.1 - 8.8e-05 22.2 0.0 0.00016 21.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC14644.1 - 0.00036 20.1 0.1 0.00064 19.3 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family AsnC_trans_reg PF01037.16 AIC14644.1 - 0.0015 18.1 0.0 0.003 17.2 0.0 1.5 1 0 0 1 1 1 1 AsnC family HTH_IclR PF09339.5 AIC14644.1 - 0.0017 17.9 0.0 0.0031 17.0 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR PF01047.17 AIC14644.1 - 0.0032 17.1 0.0 0.006 16.2 0.0 1.4 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC14644.1 - 0.0032 17.1 0.1 0.0072 16.0 0.1 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.1 AIC14644.1 - 0.028 14.4 0.1 0.047 13.7 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_11 PF08279.7 AIC14644.1 - 0.032 13.8 0.1 0.055 13.1 0.1 1.4 1 0 0 1 1 1 0 HTH domain Sigma70_r4_2 PF08281.7 AIC14644.1 - 0.071 12.5 0.1 0.21 11.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 MarR_2 PF12802.2 AIC14644.1 - 0.077 12.6 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_DeoR PF08220.7 AIC14644.1 - 0.14 11.7 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain AMMECR1 PF01871.12 AIC14645.1 - 3.4e-50 169.5 0.0 4.1e-50 169.2 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 Glyco_trans_1_3 PF13528.1 AIC14646.1 - 2.6e-27 95.8 0.0 8.5e-14 51.4 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 AIC14646.1 - 9.4e-12 44.9 0.0 1.5e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.13 AIC14646.1 - 7.2e-09 34.7 0.0 2.9e-08 32.7 0.0 1.8 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glycos_transf_1 PF00534.15 AIC14646.1 - 1.6e-05 24.3 0.0 3.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 FixQ PF05545.6 AIC14648.1 - 0.021 14.4 2.5 0.031 13.8 1.7 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF347 PF03988.7 AIC14648.1 - 0.031 14.1 1.1 0.046 13.6 0.7 1.2 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Ribosomal_S13_N PF08069.7 AIC14651.1 - 3.2e-23 81.3 0.2 6.6e-23 80.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.17 AIC14651.1 - 4.3e-16 58.4 0.2 7.3e-16 57.6 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein S15 PAX PF00292.13 AIC14651.1 - 0.048 13.3 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 'Paired box' domain DHH PF01368.15 AIC14652.1 - 4.2e-11 42.6 0.0 6.7e-11 42.0 0.0 1.3 1 0 0 1 1 1 1 DHH family DHHA1 PF02272.14 AIC14652.1 - 5.6e-07 29.1 0.0 1.8e-06 27.5 0.0 1.9 1 0 0 1 1 1 1 DHHA1 domain Pcc1 PF09341.5 AIC14653.1 - 0.001 19.0 0.0 0.0015 18.5 0.0 1.4 1 1 0 1 1 1 1 Transcription factor Pcc1 tRNA-synt_2b PF00587.20 AIC14654.1 - 3.9e-34 117.7 0.0 6.6e-34 116.9 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.17 AIC14654.1 - 1.9e-23 82.5 11.3 3.5e-23 81.6 7.8 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Mnd1 PF03962.10 AIC14654.1 - 0.087 12.4 4.8 0.18 11.4 3.3 1.5 1 0 0 1 1 1 0 Mnd1 family Methyltrn_RNA_4 PF09936.4 AIC14654.1 - 0.09 12.2 1.0 0.15 11.5 0.0 1.8 2 0 0 2 2 2 0 SAM-dependent RNA methyltransferase IncA PF04156.9 AIC14654.1 - 0.18 11.3 2.8 0.29 10.6 1.9 1.2 1 0 0 1 1 1 0 IncA protein GAS PF13851.1 AIC14654.1 - 0.35 10.0 10.2 0.69 9.0 7.0 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Spc24 PF08286.6 AIC14654.1 - 2.2 7.9 5.7 1.5 8.5 2.7 1.6 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Ribosomal_S3Ae PF01015.13 AIC14655.1 - 5.2e-48 162.9 0.9 6.2e-48 162.7 0.6 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family RNA_binding PF01877.12 AIC14656.1 - 1e-21 77.1 0.0 1.3e-21 76.8 0.0 1.1 1 0 0 1 1 1 1 RNA binding RNase_P_p30 PF01876.11 AIC14657.1 - 1.8e-07 30.5 0.0 2.1e-07 30.2 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 RNase_P_Rpp14 PF01900.14 AIC14658.1 - 0.0021 17.9 0.2 0.0033 17.3 0.1 1.5 1 1 0 1 1 1 1 Rpp14/Pop5 family T_cell_tran_alt PF15128.1 AIC14659.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.5 1 0 0 1 1 1 0 T-cell leukemia translocation-altered CDC48_N PF02359.13 AIC14660.1 - 0.0011 18.8 0.0 0.017 15.0 0.0 2.2 1 1 1 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.12 AIC14660.1 - 0.12 12.0 0.0 0.33 10.6 0.0 1.8 1 0 0 1 1 1 0 Cell division protein 48 (CDC48), domain 2 Radical_SAM PF04055.16 AIC14661.1 - 8.8e-17 61.7 0.1 3.6e-16 59.7 0.0 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Polysacc_deac_1 PF01522.16 AIC14662.1 - 2.9e-13 49.5 0.0 5.9e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 AIC14662.1 - 0.014 14.3 0.0 0.018 14.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 PhoU_div PF01865.11 AIC14663.1 - 6.2e-16 58.2 4.3 7.4e-16 57.9 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PhoU PF01895.14 AIC14663.1 - 0.00077 19.8 4.0 0.23 11.9 0.6 2.4 2 0 0 2 2 2 2 PhoU domain Reo_sigmaC PF04582.7 AIC14663.1 - 0.0012 18.0 0.5 0.62 9.1 0.1 2.1 1 1 1 2 2 2 2 Reovirus sigma C capsid protein ApoLp-III PF07464.6 AIC14663.1 - 0.0087 16.0 1.1 0.62 10.0 0.1 2.3 2 0 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) HAP1_N PF04849.8 AIC14663.1 - 0.0093 14.9 0.8 0.0093 14.9 0.5 1.7 2 0 0 2 2 2 1 HAP1 N-terminal conserved region Bacillus_HBL PF05791.6 AIC14663.1 - 0.018 14.4 0.5 2.2 7.6 0.0 2.2 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) TraD PF06412.6 AIC14663.1 - 0.059 12.9 0.2 0.37 10.4 0.1 2.2 2 0 0 2 2 2 0 Conjugal transfer protein TraD DUF4423 PF14394.1 AIC14663.1 - 0.12 11.8 1.2 0.26 10.7 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) Syntaxin_2 PF14523.1 AIC14663.1 - 0.16 12.0 1.4 0.27 11.3 0.3 1.8 2 0 0 2 2 2 0 Syntaxin-like protein ATG16 PF08614.6 AIC14663.1 - 0.57 9.9 7.4 9.1 6.0 0.0 3.0 2 1 0 3 3 3 0 Autophagy protein 16 (ATG16) Pox_A_type_inc PF04508.7 AIC14663.1 - 0.83 9.6 4.0 0.52 10.2 0.5 2.5 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Lge1 PF11488.3 AIC14663.1 - 7.7 6.7 6.0 47 4.2 1.3 3.0 2 2 0 2 2 2 0 Transcriptional regulatory protein LGE1 tRNA_int_endo PF01974.12 AIC14664.1 - 4.7e-26 90.4 0.0 7.9e-26 89.6 0.0 1.4 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.9 AIC14664.1 - 1.8e-17 62.5 0.0 2.9e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain HIRAN PF08797.6 AIC14665.1 - 0.021 14.7 0.0 0.051 13.5 0.0 1.7 1 1 0 1 1 1 0 HIRAN domain HIT PF01230.18 AIC14667.1 - 1.5e-24 86.3 0.6 2.7e-24 85.5 0.1 1.5 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.3 AIC14667.1 - 1e-14 54.7 0.0 1.5e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding UAF_Rrn10 PF05234.6 AIC14667.1 - 0.14 12.1 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 UAF complex subunit Rrn10 CwfJ_C_1 PF04677.10 AIC14667.1 - 0.48 10.0 2.4 1.1 8.9 1.7 1.8 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 DUF2515 PF10720.4 AIC14668.1 - 0.11 11.3 0.1 0.12 11.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2515) Gly-zipper_OmpA PF13436.1 AIC14669.1 - 1.5 8.4 8.7 1.2 8.7 2.1 2.5 2 1 0 2 2 2 0 Glycine-zipper containing OmpA-like membrane domain DUF937 PF06078.6 AIC14669.1 - 2.8 8.1 14.9 1.2e+02 2.9 10.3 2.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF937) Elf1 PF05129.8 AIC14670.1 - 0.0056 16.3 0.2 0.0067 16.0 0.1 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_5 PF13719.1 AIC14670.1 - 0.026 14.0 2.3 0.36 10.4 1.6 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 AIC14670.1 - 0.046 13.6 1.1 0.065 13.1 0.8 1.3 1 0 0 1 1 1 0 Zinc ribbon domain OrfB_Zn_ribbon PF07282.6 AIC14670.1 - 0.051 13.2 0.2 0.063 12.9 0.1 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_4 PF13717.1 AIC14670.1 - 0.051 13.2 1.9 1.3 8.7 1.5 2.2 1 1 0 1 1 1 0 zinc-ribbon domain Rubredoxin PF00301.15 AIC14670.1 - 0.055 13.3 0.1 2.5 8.0 0.0 2.1 2 0 0 2 2 2 0 Rubredoxin zf-H2C2_2 PF13465.1 AIC14670.1 - 0.3 11.4 1.5 1.4 9.3 0.2 2.0 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.21 AIC14670.1 - 2.1 8.8 4.0 21 5.7 0.6 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type TF_Zn_Ribbon PF08271.7 AIC14670.1 - 3.9 6.8 6.0 6.9 6.0 0.6 2.0 1 1 1 2 2 2 0 TFIIB zinc-binding ILVD_EDD PF00920.16 AIC14672.1 - 4.6e-222 738.0 9.8 5.2e-222 737.8 6.8 1.0 1 0 0 1 1 1 1 Dehydratase family Chorismate_bind PF00425.13 AIC14673.1 - 9.8e-95 316.7 0.0 9.8e-94 313.4 0.0 2.0 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.8 AIC14673.1 - 9e-25 87.3 0.0 1.7e-22 79.9 0.0 2.4 2 0 0 2 2 2 2 Anthranilate synthase component I, N terminal region PALP PF00291.20 AIC14674.1 - 1.1e-46 159.4 0.0 1.5e-46 159.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PK_C PF02887.11 AIC14674.1 - 0.0069 15.9 0.9 0.59 9.6 0.2 2.5 2 0 0 2 2 2 2 Pyruvate kinase, alpha/beta domain Snf7 PF03357.16 AIC14675.1 - 0.015 14.6 2.5 0.021 14.2 1.3 1.6 1 1 1 2 2 2 0 Snf7 Ehrlichia_rpt PF09528.5 AIC14675.1 - 0.028 12.5 0.1 0.028 12.5 0.0 1.0 1 0 0 1 1 1 0 Ehrlichia tandem repeat (Ehrlichia_rpt) EST1_DNA_bind PF10373.4 AIC14675.1 - 0.061 12.5 0.2 0.063 12.4 0.1 1.0 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain Acetyltransf_1 PF00583.19 AIC14676.1 - 5e-17 61.6 0.4 8.6e-17 60.9 0.3 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AIC14676.1 - 1.9e-12 47.1 0.1 2.9e-12 46.5 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AIC14676.1 - 1.8e-11 44.2 0.0 2.2e-11 43.9 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 AIC14676.1 - 3.3e-09 37.0 0.0 3.8e-09 36.8 0.0 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 AIC14676.1 - 5.3e-09 36.2 0.1 7.9e-09 35.6 0.1 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 AIC14676.1 - 7.4e-08 32.4 0.1 1e-07 31.9 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AIC14676.1 - 4.3e-05 23.3 0.1 6.9e-05 22.7 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3749 PF12568.3 AIC14676.1 - 0.0082 15.7 0.1 0.026 14.0 0.0 1.7 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 AIC14676.1 - 0.0082 16.0 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.5 AIC14676.1 - 0.017 14.8 0.1 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Smoothelin PF12510.3 AIC14676.1 - 0.52 10.2 3.4 0.96 9.3 2.3 1.4 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein Microvir_H PF04687.7 AIC14677.1 - 0.032 13.2 0.4 0.053 12.5 0.3 1.4 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Snf7 PF03357.16 AIC14677.1 - 0.056 12.8 6.0 0.1 11.9 4.2 1.5 1 1 0 1 1 1 0 Snf7 Aminotran_1_2 PF00155.16 AIC14679.1 - 5.9e-56 189.9 0.3 6.9e-56 189.7 0.2 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 AIC14679.1 - 1.1e-05 23.9 0.0 1.6e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 AIC14679.1 - 0.00015 20.9 0.0 0.0019 17.4 0.0 2.2 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.14 AIC14679.1 - 0.0042 15.8 0.3 0.0064 15.2 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class-V BATS PF06968.8 AIC14680.1 - 2.1e-23 81.9 0.0 6.1e-23 80.4 0.0 1.8 1 0 0 1 1 1 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.16 AIC14680.1 - 7.7e-15 55.4 0.6 1.4e-14 54.5 0.4 1.4 1 0 0 1 1 1 1 Radical SAM superfamily DeoC PF01791.4 AIC14680.1 - 0.018 14.3 0.2 1.2 8.3 0.0 2.6 2 1 0 3 3 3 0 DeoC/LacD family aldolase Opiods_neuropep PF01160.13 AIC14680.1 - 0.83 9.4 3.5 6.8 6.5 0.2 2.4 2 0 0 2 2 2 0 Vertebrate endogenous opioids neuropeptide Cupin_2 PF07883.6 AIC14681.1 - 1.9e-12 46.5 0.1 3.5e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.14 AIC14681.1 - 2.2e-07 30.6 0.0 3.3e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain EutQ PF06249.7 AIC14681.1 - 5.5e-06 25.9 0.0 9.5e-06 25.2 0.0 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.7 AIC14681.1 - 3e-05 23.2 0.0 7e-05 22.1 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF861) MannoseP_isomer PF01050.13 AIC14681.1 - 0.0012 18.4 0.0 0.0017 18.0 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_6 PF12852.2 AIC14681.1 - 0.0013 18.4 0.0 0.0017 18.0 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_7 PF12973.2 AIC14681.1 - 0.0025 17.6 0.0 0.0038 17.0 0.0 1.3 1 0 0 1 1 1 1 ChrR Cupin-like domain Cupin_1 PF00190.17 AIC14681.1 - 0.011 15.2 0.0 0.025 14.0 0.0 1.6 1 1 0 1 1 1 0 Cupin ARD PF03079.9 AIC14681.1 - 0.023 14.6 0.0 0.04 13.8 0.0 1.4 1 1 0 1 1 1 0 ARD/ARD' family Resolvase PF00239.16 AIC14682.1 - 1.4e-32 112.5 0.1 2e-32 112.0 0.1 1.2 1 0 0 1 1 1 1 Resolvase, N terminal domain HTH_7 PF02796.10 AIC14682.1 - 6.8e-07 29.0 0.2 1.5e-06 27.9 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.1 AIC14682.1 - 1.2e-06 27.9 0.1 1.2e-06 27.9 0.1 1.9 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.1 AIC14682.1 - 6.1e-06 25.6 0.2 1.8e-05 24.1 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.1 AIC14682.1 - 0.00026 20.9 0.6 0.00083 19.3 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.8 AIC14682.1 - 0.00045 19.5 0.2 0.0027 17.0 0.0 2.3 2 1 1 3 3 3 1 CENP-B N-terminal DNA-binding domain HTH_30 PF13556.1 AIC14682.1 - 0.00086 18.8 0.1 0.0017 17.9 0.1 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_11 PF08279.7 AIC14682.1 - 0.002 17.7 0.7 0.0053 16.3 0.5 1.8 1 0 0 1 1 1 1 HTH domain HTH_8 PF02954.14 AIC14682.1 - 0.003 17.0 0.8 0.003 17.0 0.6 2.1 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family HTH_10 PF04967.7 AIC14682.1 - 0.0039 16.7 0.2 0.0091 15.5 0.1 1.6 1 0 0 1 1 1 1 HTH DNA binding domain HTH_22 PF13309.1 AIC14682.1 - 0.0099 15.6 0.0 0.027 14.1 0.0 1.8 1 0 0 1 1 1 1 HTH domain TetR_N PF00440.18 AIC14682.1 - 0.013 15.1 0.1 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_29 PF13551.1 AIC14682.1 - 0.013 15.6 1.2 0.066 13.3 0.1 2.4 1 1 1 2 2 2 0 Winged helix-turn helix HTH_Tnp_ISL3 PF13542.1 AIC14682.1 - 0.02 14.0 0.0 0.05 12.7 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_Tnp_1 PF01527.15 AIC14682.1 - 0.022 14.7 0.3 0.054 13.4 0.0 1.8 2 0 0 2 2 2 0 Transposase DUF1492 PF07374.6 AIC14682.1 - 0.031 14.3 0.2 0.15 12.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) Mga PF05043.8 AIC14682.1 - 0.13 12.5 0.2 0.42 10.9 0.0 1.8 2 0 0 2 2 2 0 Mga helix-turn-helix domain Sigma70_r4_2 PF08281.7 AIC14682.1 - 0.17 11.3 1.1 0.26 10.7 0.1 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 Aminotran_3 PF00202.16 AIC14683.1 - 3.3e-90 302.3 0.0 3.9e-90 302.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III FAD_binding_2 PF00890.19 AIC14683.1 - 0.0038 16.1 0.1 0.011 14.6 0.0 1.8 3 0 0 3 3 3 1 FAD binding domain Aminotran_1_2 PF00155.16 AIC14683.1 - 0.014 14.3 0.1 0.043 12.7 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class I and II AAA_26 PF13500.1 AIC14684.1 - 6e-42 143.5 0.0 7.3e-42 143.2 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.18 AIC14684.1 - 1.4e-13 50.6 0.0 2.2e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CTP_synth_N PF06418.9 AIC14684.1 - 0.0023 17.1 0.2 0.089 11.8 0.0 2.7 3 0 0 3 3 3 1 CTP synthase N-terminus ParA PF10609.4 AIC14684.1 - 0.0025 17.6 0.0 0.0052 16.6 0.0 1.5 1 0 0 1 1 1 1 ParA/MinD ATPase like ArsA_ATPase PF02374.10 AIC14684.1 - 0.0043 16.1 0.8 0.013 14.5 0.1 2.1 2 1 1 3 3 3 1 Anion-transporting ATPase MobB PF03205.9 AIC14684.1 - 0.021 14.4 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF1611 PF07755.6 AIC14684.1 - 0.024 13.2 0.5 0.23 10.0 0.3 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1611) AAA_18 PF13238.1 AIC14684.1 - 0.047 13.9 0.0 0.076 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain NTPase_1 PF03266.10 AIC14684.1 - 0.11 12.2 0.4 1.7 8.3 0.1 2.3 2 0 0 2 2 2 0 NTPase DUF2975 PF11188.3 AIC14686.1 - 0.025 14.3 2.9 0.68 9.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) SLAC1 PF03595.12 AIC14686.1 - 0.93 8.0 6.0 1.2 7.7 4.1 1.2 1 1 0 1 1 1 0 Voltage-dependent anion channel DUF202 PF02656.10 AIC14686.1 - 6.3 7.0 9.1 19 5.5 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF202) NTP_transferase PF00483.18 AIC14687.1 - 4.6e-34 117.8 0.0 8.6e-34 116.9 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 AIC14687.1 - 2.9e-08 33.9 0.0 4e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 AIC14687.1 - 0.0085 15.6 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Bac_luciferase PF00296.15 AIC14688.1 - 2.4e-65 220.6 0.0 2.8e-65 220.4 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Thiolase_C PF02803.13 AIC14689.1 - 1.5e-09 37.3 1.4 2.5e-09 36.6 0.4 1.8 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.5 AIC14689.1 - 1.2e-06 28.0 0.1 4.3e-05 23.0 0.0 2.7 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Thiolase_N PF00108.18 AIC14689.1 - 0.00038 19.5 0.4 0.003 16.5 0.1 2.4 2 0 0 2 2 2 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 AIC14689.1 - 0.0005 19.6 0.4 0.0012 18.3 0.1 1.8 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 AIC14689.1 - 0.004 16.9 4.4 0.12 12.2 0.0 3.3 2 1 1 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain DUF35 PF01796.12 AIC14690.1 - 8.2e-05 22.7 0.0 0.00015 21.9 0.0 1.4 1 0 0 1 1 1 1 DUF35 OB-fold domain DUF35_N PF12172.3 AIC14690.1 - 0.00011 21.9 2.7 0.00023 20.9 1.9 1.6 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) Zn_Tnp_IS1595 PF12760.2 AIC14690.1 - 5.9 6.7 5.9 1.1 9.1 0.8 2.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF3689 PF12463.3 AIC14691.1 - 0.024 13.4 0.1 0.032 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3689) DUF3107 PF11305.3 AIC14692.1 - 0.017 14.9 0.1 0.059 13.2 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3107) Ribosomal_L6 PF00347.18 AIC14693.1 - 2.2e-17 63.3 8.4 3.8e-09 36.8 1.5 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 Ribosomal_S8 PF00410.14 AIC14694.1 - 6.2e-24 84.2 0.0 8.1e-24 83.9 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S14 PF00253.16 AIC14695.1 - 3.4e-16 58.3 5.1 4.5e-16 57.9 3.5 1.3 1 1 0 1 1 1 1 Ribosomal protein S14p/S29e zf-tcix PF14952.1 AIC14695.1 - 0.012 14.9 4.3 0.026 13.8 3.0 1.7 1 1 0 1 1 1 0 Putative treble-clef, zinc-finger, Zn-binding DZR PF12773.2 AIC14695.1 - 0.11 12.3 0.4 0.17 11.7 0.3 1.4 1 1 0 1 1 1 0 Double zinc ribbon Ribosomal_L5_C PF00673.16 AIC14696.1 - 3.1e-25 87.7 0.0 4.6e-25 87.1 0.0 1.3 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.14 AIC14696.1 - 3.1e-13 49.2 0.1 5.9e-13 48.3 0.1 1.5 1 0 0 1 1 1 1 Ribosomal protein L5 Prefoldin PF02996.12 AIC14696.1 - 0.15 11.6 1.2 4.3 7.0 0.1 2.6 2 1 1 3 3 3 0 Prefoldin subunit Ribosomal_S4e PF00900.15 AIC14697.1 - 2.2e-18 65.6 0.0 4.5e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.7 AIC14697.1 - 2.1e-11 43.4 0.8 3.3e-11 42.8 0.6 1.3 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.20 AIC14697.1 - 5.6e-06 25.6 0.2 1.3e-05 24.5 0.1 1.7 1 0 0 1 1 1 1 S4 domain DPCD PF14913.1 AIC14697.1 - 0.13 11.3 0.0 0.26 10.3 0.0 1.6 1 0 0 1 1 1 0 DPCD protein family KOW PF00467.24 AIC14698.1 - 2.6e-05 23.7 3.1 2.6e-05 23.7 2.1 2.0 2 0 0 2 2 2 1 KOW motif CMAS PF02353.15 AIC14698.1 - 0.005 15.9 0.1 0.0072 15.4 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase RR_TM4-6 PF06459.7 AIC14698.1 - 0.58 10.0 6.1 0.57 10.0 4.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L14 PF00238.14 AIC14699.1 - 9.7e-34 115.7 0.0 1.1e-33 115.5 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ribosomal_S17 PF00366.15 AIC14700.1 - 1.1e-21 76.6 2.2 1.3e-21 76.3 1.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 DUF4411 PF14367.1 AIC14700.1 - 0.046 13.4 0.0 0.053 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) UPF0086 PF01868.11 AIC14701.1 - 3.8e-20 71.3 0.0 4.4e-20 71.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Ribosomal_L29 PF00831.18 AIC14702.1 - 1.1e-15 57.0 3.5 1.3e-15 56.8 2.4 1.1 1 0 0 1 1 1 1 Ribosomal L29 protein Vps51 PF08700.6 AIC14702.1 - 0.19 11.5 1.2 4.6 7.1 0.2 2.1 2 0 0 2 2 2 0 Vps51/Vps67 Ist1 PF03398.9 AIC14702.1 - 0.19 11.0 3.4 3.4 7.0 0.1 2.0 1 1 1 2 2 2 0 Regulator of Vps4 activity in the MVB pathway KH_2 PF07650.12 AIC14703.1 - 8.4e-14 50.9 0.0 1.4e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 KH domain Ribosomal_S3_C PF00189.15 AIC14703.1 - 5.3e-13 48.9 0.6 1e-12 48.0 0.2 1.6 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_1 PF00013.24 AIC14703.1 - 0.026 14.1 0.4 0.062 12.9 0.1 1.8 2 0 0 2 2 2 0 KH domain KH_3 PF13014.1 AIC14703.1 - 0.095 12.3 1.2 0.22 11.2 0.2 2.1 2 0 0 2 2 2 0 KH domain Ribosomal_L22 PF00237.14 AIC14704.1 - 7.9e-31 106.1 0.9 1e-30 105.7 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S19 PF00203.16 AIC14705.1 - 4.4e-26 90.3 0.1 5.5e-26 89.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L23 PF00276.15 AIC14706.1 - 2.9e-12 46.3 1.2 1.7e-11 43.8 0.8 1.9 1 1 0 1 1 1 1 Ribosomal protein L23 RRM_6 PF14259.1 AIC14706.1 - 0.045 13.7 0.0 0.065 13.2 0.0 1.4 1 1 0 1 1 1 0 RNA recognition motif (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L4 PF00573.17 AIC14707.1 - 3.1e-37 127.8 0.8 3.7e-37 127.6 0.5 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_L3 PF00297.17 AIC14708.1 - 7e-56 189.5 3.3 8.2e-56 189.3 2.3 1.0 1 0 0 1 1 1 1 Ribosomal protein L3 Stap_Strp_toxin PF01123.15 AIC14708.1 - 0.075 13.5 0.0 0.16 12.5 0.0 1.5 1 0 0 1 1 1 0 Staphylococcal/Streptococcal toxin, OB-fold domain Methyltrn_RNA_3 PF02598.12 AIC14709.1 - 2.6e-46 158.3 0.0 3e-46 158.0 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase SPOUT_MTase_2 PF14419.1 AIC14709.1 - 1.4e-05 24.4 0.0 2.5e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 AF2226-like SPOUT RNA Methylase fused to THUMP AhpC-TSA PF00578.16 AIC14710.1 - 3.5e-08 33.1 0.0 1.6e-06 27.8 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AIC14710.1 - 1.4e-07 31.1 0.0 1.9e-05 24.2 0.0 2.2 2 0 0 2 2 2 2 Redoxin Thioredoxin_2 PF13098.1 AIC14710.1 - 0.00034 20.7 0.1 0.011 15.8 0.0 2.2 2 0 0 2 2 2 1 Thioredoxin-like domain GSHPx PF00255.14 AIC14710.1 - 0.022 14.1 0.1 0.043 13.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione peroxidase Thioredoxin_8 PF13905.1 AIC14710.1 - 0.093 12.8 0.1 4.4 7.4 0.0 2.5 2 1 0 2 2 2 0 Thioredoxin-like DUF164 PF02591.10 AIC14710.1 - 0.18 11.6 0.2 0.39 10.5 0.1 1.5 1 1 0 1 1 1 0 Putative zinc ribbon domain Proteasome PF00227.21 AIC14711.1 - 2.3e-57 193.3 0.5 3e-57 192.9 0.4 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.4 AIC14711.1 - 8.7e-15 53.7 0.8 5.1e-14 51.2 0.1 2.4 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature Synuclein PF01387.12 AIC14711.1 - 0.024 14.5 0.9 0.044 13.6 0.1 1.8 2 0 0 2 2 2 0 Synuclein DUF371 PF04027.8 AIC14713.1 - 1.9e-41 140.8 0.4 2.1e-41 140.6 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF371) HTH_20 PF12840.2 AIC14714.1 - 8.2e-13 47.9 0.4 1.7e-12 46.9 0.3 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC14714.1 - 9.9e-10 37.9 0.1 4.9e-09 35.7 0.1 2.0 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_12 PF08461.5 AIC14714.1 - 1.1e-05 25.0 0.1 2.3e-05 23.9 0.1 1.5 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain HTH_24 PF13412.1 AIC14714.1 - 3.7e-05 23.0 0.0 8.4e-05 21.8 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding PadR PF03551.9 AIC14714.1 - 0.00013 21.6 0.1 0.00033 20.3 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulator PadR-like family TrmB PF01978.14 AIC14714.1 - 0.00074 19.1 0.1 0.0017 18.0 0.0 1.6 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF2088 PF09861.4 AIC14714.1 - 0.0041 16.1 0.3 0.022 13.7 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF2088) TFIIE_alpha PF02002.12 AIC14714.1 - 0.011 15.2 0.1 0.029 13.8 0.0 1.7 2 0 0 2 2 2 0 TFIIE alpha subunit MarR_2 PF12802.2 AIC14714.1 - 0.014 15.0 0.0 0.075 12.7 0.0 2.1 1 1 0 1 1 1 0 MarR family HTH_11 PF08279.7 AIC14714.1 - 0.015 14.9 0.1 0.21 11.2 0.0 2.2 1 1 0 1 1 1 0 HTH domain FUR PF01475.14 AIC14714.1 - 0.028 14.3 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 Ferric uptake regulator family DUF4423 PF14394.1 AIC14714.1 - 0.03 13.8 0.0 0.047 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Ribosomal_L12 PF00542.14 AIC14714.1 - 0.05 13.6 1.5 1.1 9.3 0.0 2.7 2 1 0 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain DUF2250 PF10007.4 AIC14714.1 - 0.082 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) LexA_DNA_bind PF01726.11 AIC14714.1 - 0.1 12.2 0.1 0.21 11.1 0.1 1.6 1 0 0 1 1 1 0 LexA DNA binding domain DUF4093 PF13331.1 AIC14714.1 - 0.11 12.7 0.4 0.57 10.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4093) SAICAR_synt PF01259.13 AIC14715.1 - 5.5e-66 222.1 0.0 6.7e-66 221.9 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase ATP-grasp PF02222.17 AIC14716.1 - 1.7e-59 200.0 0.1 2.6e-59 199.4 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.1 AIC14716.1 - 7.3e-18 64.9 0.1 1.1e-17 64.3 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 AIC14716.1 - 1.7e-09 36.9 0.2 8e-07 28.1 0.0 2.2 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon Dala_Dala_lig_C PF07478.8 AIC14716.1 - 1e-06 28.2 0.0 6.2e-06 25.7 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus RimK PF08443.6 AIC14716.1 - 2.3e-06 27.2 0.0 4.6e-06 26.2 0.0 1.5 1 1 0 1 1 1 1 RimK-like ATP-grasp domain CPSase_L_D2 PF02786.12 AIC14716.1 - 1.2e-05 24.7 0.0 2.1e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.9 AIC14716.1 - 2.2e-05 24.3 0.1 4.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain GARS_A PF01071.14 AIC14716.1 - 0.014 14.9 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.1 AIC14716.1 - 0.036 13.2 0.0 0.089 11.9 0.0 1.6 1 1 0 1 1 1 0 ATP-grasp domain ATP-grasp_2 PF08442.5 AIC14716.1 - 0.084 12.2 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain AIRC PF00731.15 AIC14717.1 - 4.4e-68 227.2 2.1 5.1e-68 227.0 1.4 1.0 1 0 0 1 1 1 1 AIR carboxylase CoA_binding_2 PF13380.1 AIC14717.1 - 0.0089 16.1 0.1 1.9 8.6 0.0 2.2 1 1 1 2 2 2 2 CoA binding domain PrpR_N PF06506.6 AIC14717.1 - 0.055 12.8 0.1 0.097 12.0 0.0 1.4 1 1 0 1 1 1 0 Propionate catabolism activator Nif11 PF07862.6 AIC14719.1 - 0.12 12.3 0.3 0.26 11.2 0.2 1.5 1 0 0 1 1 1 0 Nitrogen fixation protein of unknown function adh_short PF00106.20 AIC14720.1 - 1.9e-33 115.7 0.3 3.1e-24 85.7 0.0 3.0 3 0 0 3 3 3 2 short chain dehydrogenase adh_short_C2 PF13561.1 AIC14720.1 - 4.7e-22 78.9 0.7 2.3e-16 60.3 0.0 3.1 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AIC14720.1 - 3e-18 66.1 0.7 1e-11 44.8 0.0 3.3 4 1 0 4 4 4 2 KR domain Epimerase PF01370.16 AIC14720.1 - 3.1e-07 30.0 0.6 0.0067 15.8 0.1 2.6 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.13 AIC14720.1 - 0.00068 19.3 0.3 0.00068 19.3 0.2 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 AIC14720.1 - 0.0013 17.8 1.1 0.0023 17.0 0.2 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.14 AIC14720.1 - 0.003 16.6 0.5 0.028 13.4 0.1 2.5 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain ApbA PF02558.11 AIC14720.1 - 0.0094 15.4 0.1 2 7.8 0.0 2.5 2 0 0 2 2 2 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.12 AIC14720.1 - 0.0097 16.3 0.5 0.048 14.1 0.2 2.4 2 0 0 2 2 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_10 PF13460.1 AIC14720.1 - 0.021 14.8 2.7 0.81 9.6 0.3 3.3 2 1 0 2 2 2 0 NADH(P)-binding Eno-Rase_NADH_b PF12242.3 AIC14720.1 - 0.024 14.4 1.4 0.054 13.2 0.1 2.2 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NAD_binding_7 PF13241.1 AIC14720.1 - 0.031 14.5 0.9 0.29 11.3 0.1 2.8 3 1 0 3 3 3 0 Putative NAD(P)-binding Shikimate_DH PF01488.15 AIC14720.1 - 0.059 13.4 2.1 0.14 12.2 0.1 2.6 4 0 0 4 4 4 0 Shikimate / quinate 5-dehydrogenase HMG_box_5 PF14887.1 AIC14720.1 - 0.11 12.2 0.0 0.27 11.0 0.0 1.6 1 0 0 1 1 1 0 HMG (high mobility group) box 5 TauE PF01925.14 AIC14721.1 - 4.5e-51 173.6 36.0 5.6e-51 173.3 25.0 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE PIG-U PF06728.8 AIC14721.1 - 0.12 11.1 4.5 2.6 6.8 0.6 2.3 1 1 1 2 2 2 0 GPI transamidase subunit PIG-U HTH_AsnC-type PF13404.1 AIC14722.1 - 1.6e-10 40.3 1.4 2.4e-10 39.7 0.1 2.0 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.16 AIC14722.1 - 2.7e-10 39.8 0.4 1.1e-09 37.8 0.0 2.1 3 0 0 3 3 3 1 AsnC family HTH_24 PF13412.1 AIC14722.1 - 1.1e-08 34.3 0.3 2.1e-08 33.4 0.2 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.7 AIC14722.1 - 0.00011 21.7 0.2 0.00022 20.7 0.1 1.4 1 0 0 1 1 1 1 HTH domain HrcA_DNA-bdg PF03444.10 AIC14722.1 - 0.00016 21.0 0.2 0.00053 19.3 0.1 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding Replic_Relax PF13814.1 AIC14722.1 - 0.013 15.3 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 Replication-relaxation NapD PF03927.8 AIC14722.1 - 0.018 14.8 0.1 0.035 13.9 0.1 1.4 1 0 0 1 1 1 0 NapD protein DUF2250 PF10007.4 AIC14722.1 - 0.043 13.7 0.0 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_Crp_2 PF13545.1 AIC14722.1 - 0.05 13.4 0.1 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_DeoR PF08220.7 AIC14722.1 - 0.052 13.0 0.3 0.093 12.2 0.2 1.4 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_Mga PF08280.6 AIC14722.1 - 0.056 13.2 0.0 0.095 12.4 0.0 1.3 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_20 PF12840.2 AIC14722.1 - 0.064 13.0 0.1 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain MarR PF01047.17 AIC14722.1 - 0.067 12.9 0.1 0.17 11.5 0.1 1.6 2 0 0 2 2 2 0 MarR family HTH_23 PF13384.1 AIC14722.1 - 0.095 12.3 0.3 0.5 10.0 0.1 2.2 2 0 0 2 2 2 0 Homeodomain-like domain MarR_2 PF12802.2 AIC14722.1 - 0.13 11.9 1.4 0.72 9.5 0.1 2.5 2 1 1 3 3 3 0 MarR family Homoserine_dh PF00742.14 AIC14723.1 - 4e-55 186.2 0.1 8.3e-55 185.2 0.1 1.5 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.11 AIC14723.1 - 3.4e-08 33.8 0.0 1.4e-07 31.9 0.0 2.0 2 0 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.16 AIC14723.1 - 2.9e-05 23.7 0.1 7.7e-05 22.3 0.0 1.7 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GFO_IDH_MocA PF01408.17 AIC14723.1 - 0.041 14.3 0.0 0.089 13.3 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold zinc_ribbon_6 PF14599.1 AIC14724.1 - 0.01 15.6 0.3 0.011 15.4 0.2 1.2 1 0 0 1 1 1 0 Zinc-ribbon DZR PF12773.2 AIC14724.1 - 0.095 12.5 1.4 0.19 11.5 1.0 1.6 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 AIC14724.1 - 0.15 11.6 1.4 1.8 8.1 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain AIM24 PF01987.12 AIC14725.1 - 6e-56 189.2 1.3 6.9e-56 189.0 0.9 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Lon_C PF05362.8 AIC14725.1 - 0.15 11.3 0.4 0.72 9.1 0.0 1.9 2 0 0 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain PUA PF01472.15 AIC14726.1 - 1.1e-17 63.4 0.2 1.9e-17 62.7 0.1 1.4 1 0 0 1 1 1 1 PUA domain HTH_24 PF13412.1 AIC14727.1 - 2.9e-08 32.9 0.4 6.7e-08 31.7 0.3 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC14727.1 - 3.1e-05 23.4 0.6 7.4e-05 22.2 0.4 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_28 PF13518.1 AIC14727.1 - 0.0069 16.3 0.0 0.018 14.9 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_IclR PF09339.5 AIC14727.1 - 0.047 13.2 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_8 PF02954.14 AIC14727.1 - 0.049 13.1 0.0 0.12 11.9 0.0 1.6 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_20 PF12840.2 AIC14727.1 - 0.097 12.4 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.1 AIC14727.1 - 0.11 12.2 0.0 0.31 10.7 0.0 1.8 1 1 0 1 1 1 0 Homeodomain-like domain Proteasome PF00227.21 AIC14728.1 - 2.9e-48 163.6 0.1 3.4e-48 163.4 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit P5CR_dimer PF14748.1 AIC14728.1 - 0.047 13.6 0.2 0.1 12.6 0.1 1.5 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation HATPase_c_3 PF13589.1 AIC14729.1 - 1e-11 44.6 0.0 2.1e-11 43.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.21 AIC14729.1 - 0.018 14.7 0.0 0.046 13.4 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Copper-bind PF00127.15 AIC14730.1 - 2.7e-08 33.9 0.0 3.6e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC14730.1 - 8.1e-06 25.6 0.0 1.8e-05 24.5 0.0 1.5 1 1 0 1 1 1 1 Cupredoxin-like domain eRF1_2 PF03464.10 AIC14732.1 - 2.1e-34 118.7 0.0 4.4e-34 117.6 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_1 PF03463.10 AIC14732.1 - 5.9e-19 67.9 0.0 1e-18 67.1 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.10 AIC14732.1 - 7.5e-18 64.8 0.2 1.8e-17 63.6 0.2 1.7 1 0 0 1 1 1 1 eRF1 domain 3 zf-FPG_IleRS PF06827.9 AIC14732.1 - 0.017 14.7 0.3 6 6.6 0.0 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS HypA PF01155.14 AIC14732.1 - 0.057 13.0 0.1 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Lar_restr_allev PF14354.1 AIC14732.1 - 0.28 11.4 2.6 0.68 10.2 0.2 2.4 1 1 1 2 2 2 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.5 AIC14732.1 - 3.4 7.6 5.7 6.6 6.7 2.4 2.5 2 1 0 2 2 2 0 Zinc ribbon domain CBS PF00571.23 AIC14733.1 - 2.9e-15 55.7 2.9 3.9e-11 42.5 0.0 2.8 2 1 0 2 2 2 2 CBS domain HTH_3 PF01381.17 AIC14733.1 - 7.5e-13 48.1 0.4 1.7e-12 47.0 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_19 PF12844.2 AIC14733.1 - 1.3e-12 47.5 0.1 3.4e-12 46.2 0.1 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.1 AIC14733.1 - 1.6e-12 47.4 0.0 2.5e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.1 AIC14733.1 - 0.00044 19.8 0.0 0.00075 19.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain CoA_binding_2 PF13380.1 AIC14733.1 - 0.0013 18.8 0.1 0.0024 18.0 0.1 1.4 1 1 0 1 1 1 1 CoA binding domain HTH_37 PF13744.1 AIC14733.1 - 0.074 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_26 PF13443.1 AIC14733.1 - 0.098 12.8 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 Cro/C1-type HTH DNA-binding domain DUF1272 PF06906.6 AIC14734.1 - 0.013 15.2 5.7 0.017 14.9 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) MSSP PF03940.8 AIC14734.1 - 0.83 9.0 10.6 1.3 8.5 7.3 1.3 1 1 0 1 1 1 0 Male specific sperm protein HypA PF01155.14 AIC14734.1 - 1.2 8.8 5.1 1.3 8.7 3.6 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family BacA PF02673.13 AIC14735.1 - 9.7e-67 224.8 16.1 1.1e-66 224.6 11.1 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA Tmemb_170 PF10190.4 AIC14735.1 - 0.062 13.3 0.2 0.062 13.3 0.1 2.9 3 0 0 3 3 3 0 Putative transmembrane protein 170 Gp_dh_N PF00044.19 AIC14737.1 - 4.5e-09 36.4 1.4 1.8e-08 34.5 0.5 2.3 3 1 0 3 3 3 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.15 AIC14737.1 - 7.9e-06 25.8 0.4 1.9e-05 24.5 0.2 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_3 PF03447.11 AIC14737.1 - 0.0012 19.2 0.1 0.0031 17.9 0.1 1.7 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain Gp_dh_C PF02800.15 AIC14737.1 - 0.016 14.6 0.0 0.15 11.5 0.0 2.3 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain F420_oxidored PF03807.12 AIC14737.1 - 0.021 15.2 0.5 0.2 12.1 0.4 2.3 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.13 AIC14737.1 - 0.046 13.7 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 TrkA-N domain GATase PF00117.23 AIC14738.1 - 1.4e-57 194.2 0.0 1.6e-57 194.0 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AIC14738.1 - 3.9e-11 42.8 0.0 6e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase C26 Glycos_transf_3 PF00591.16 AIC14739.1 - 4.7e-79 265.3 0.9 4.7e-79 265.3 0.6 1.5 2 0 0 2 2 2 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.12 AIC14739.1 - 5.4e-19 67.5 2.9 1.1e-18 66.5 2.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Acyl_transf_1 PF00698.16 AIC14739.1 - 0.046 13.0 0.2 0.12 11.7 0.1 1.7 1 1 0 1 1 1 0 Acyl transferase domain YccJ PF13993.1 AIC14739.1 - 0.15 12.1 0.1 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 YccJ-like protein Rad51 PF08423.6 AIC14740.1 - 1.1e-88 296.5 0.0 1.4e-88 296.1 0.0 1.1 1 0 0 1 1 1 1 Rad51 KaiC PF06745.8 AIC14740.1 - 4e-11 42.4 0.2 8.2e-11 41.4 0.0 1.6 2 0 0 2 2 2 1 KaiC AAA_25 PF13481.1 AIC14740.1 - 7.6e-11 41.7 0.0 1.2e-10 41.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.1 AIC14740.1 - 1.8e-10 40.8 1.1 3.1e-10 40.0 0.3 1.8 2 0 0 2 2 2 1 Helix-hairpin-helix domain RecA PF00154.16 AIC14740.1 - 3.9e-09 36.0 0.1 6.2e-09 35.3 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein DUF4332 PF14229.1 AIC14740.1 - 0.0025 17.7 0.0 0.009 15.9 0.0 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4332) Cdd1 PF11731.3 AIC14740.1 - 0.0049 16.7 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 Pathogenicity locus DNA_pol_lambd_f PF10391.4 AIC14740.1 - 0.014 14.9 0.0 0.042 13.4 0.0 1.8 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda TfoX_C PF04994.8 AIC14740.1 - 0.042 13.7 0.0 0.13 12.2 0.0 1.8 1 1 1 2 2 2 0 TfoX C-terminal domain AAA PF00004.24 AIC14740.1 - 0.049 13.8 0.1 0.29 11.3 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) HHH PF00633.18 AIC14740.1 - 0.069 12.8 0.0 0.18 11.5 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif TrwB_AAD_bind PF10412.4 AIC14740.1 - 0.09 11.3 0.0 0.16 10.5 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain zinc_ribbon_2 PF13240.1 AIC14741.1 - 0.017 14.6 0.1 0.049 13.1 0.1 1.7 1 1 0 1 1 1 0 zinc-ribbon domain Ribosomal_60s PF00428.14 AIC14741.1 - 0.064 13.6 3.9 0.073 13.4 2.7 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein HypA PF01155.14 AIC14741.1 - 0.068 12.8 0.7 0.089 12.4 0.5 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Auto_anti-p27 PF06677.7 AIC14741.1 - 0.11 12.3 2.8 0.26 11.0 0.1 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Cytochrome_C7 PF14522.1 AIC14741.1 - 0.14 11.8 0.8 0.18 11.4 0.6 1.4 1 1 0 1 1 1 0 Cytochrome c7 Cytochrome_C554 PF13435.1 AIC14741.1 - 0.18 11.8 2.7 0.21 11.6 1.9 1.1 1 0 0 1 1 1 0 Cytochrome c554 and c-prime DZR PF12773.2 AIC14741.1 - 0.27 11.0 2.8 0.72 9.7 1.9 1.8 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.1 AIC14741.1 - 0.27 10.9 3.3 0.91 9.2 2.3 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zf-IS66 PF13005.2 AIC14741.1 - 0.31 11.0 2.2 0.86 9.6 0.2 2.0 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 zinc_ribbon_5 PF13719.1 AIC14741.1 - 0.5 9.9 3.4 1.8 8.2 2.4 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zf-RanBP PF00641.13 AIC14741.1 - 0.7 9.0 4.4 3.9 6.6 0.3 2.4 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zf-NADH-PPase PF09297.6 AIC14741.1 - 0.93 9.0 3.5 0.34 10.4 0.4 1.7 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Uso1_p115_C PF04871.8 AIC14742.1 - 0.001 18.9 3.7 0.001 18.9 2.5 3.5 1 1 2 4 4 4 1 Uso1 / p115 like vesicle tethering protein, C terminal region Atg14 PF10186.4 AIC14742.1 - 0.0056 15.6 3.2 0.0056 15.6 2.2 2.1 1 1 1 2 2 2 1 UV radiation resistance protein and autophagy-related subunit 14 TMPIT PF07851.8 AIC14742.1 - 0.0059 15.7 2.3 0.0059 15.7 1.6 2.0 1 1 1 2 2 2 1 TMPIT-like protein tRNA-Thr_ED PF08915.6 AIC14742.1 - 0.02 14.8 2.9 0.11 12.4 0.1 2.6 1 1 0 2 2 2 0 Archaea-specific editing domain of threonyl-tRNA synthetase Baculo_PEP_C PF04513.7 AIC14742.1 - 0.024 14.4 3.6 1.8 8.3 0.7 3.0 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0228 PF05727.6 AIC14742.1 - 0.028 14.1 1.1 0.028 14.1 0.8 2.6 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0228) NAAA-beta PF15508.1 AIC14742.1 - 0.03 14.6 0.9 0.12 12.6 0.2 2.3 2 1 0 2 2 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase UPF0184 PF03670.8 AIC14742.1 - 0.056 13.6 4.0 0.44 10.7 0.0 3.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) SNARE PF05739.14 AIC14742.1 - 0.061 13.0 3.1 0.064 12.9 0.3 2.5 2 0 0 2 2 2 0 SNARE domain BcsB PF03170.8 AIC14742.1 - 0.069 11.1 0.1 0.11 10.5 0.1 1.2 1 0 0 1 1 1 0 Bacterial cellulose synthase subunit Reo_sigmaC PF04582.7 AIC14742.1 - 0.1 11.7 6.3 0.072 12.2 1.4 2.0 1 1 1 2 2 2 0 Reovirus sigma C capsid protein DUF2408 PF10303.4 AIC14742.1 - 0.16 12.0 8.2 0.097 12.7 3.6 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2408) NPV_P10 PF05531.7 AIC14742.1 - 0.17 12.1 6.2 1.5 9.0 0.8 3.6 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein MtrG PF04210.8 AIC14742.1 - 0.28 10.8 2.5 8.7 6.0 0.1 3.3 2 1 1 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF2205 PF10224.4 AIC14742.1 - 0.66 9.5 6.8 0.32 10.5 0.2 3.1 2 2 0 2 2 2 0 Predicted coiled-coil protein (DUF2205) DUF3138 PF11336.3 AIC14742.1 - 0.66 8.0 2.3 0.56 8.3 0.6 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) FUSC PF04632.7 AIC14742.1 - 1.1 7.6 4.2 1.4 7.2 2.9 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Nup54 PF13874.1 AIC14742.1 - 1.2 8.7 14.7 0.91 9.1 4.4 3.0 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 WASH_WAHD PF11945.3 AIC14742.1 - 2.7 7.1 9.3 7 5.8 6.5 1.8 1 1 0 1 1 1 0 WAHD domain of WASH complex Occludin_ELL PF07303.8 AIC14742.1 - 3.5 8.4 11.8 2.5 8.8 0.4 3.5 1 1 2 3 3 3 0 Occludin homology domain DUF1664 PF07889.7 AIC14742.1 - 3.8 7.3 14.8 2.1 8.1 1.9 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) APG6 PF04111.7 AIC14742.1 - 4.7 6.1 16.6 3.6 6.5 5.5 2.1 1 1 1 2 2 2 0 Autophagy protein Apg6 Calci_bind_CcbP PF11535.3 AIC14744.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.2 1 0 0 1 1 1 0 Calcium binding Trp_syntA PF00290.15 AIC14745.1 - 5.6e-90 300.3 0.0 6.3e-90 300.1 0.0 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain His_biosynth PF00977.16 AIC14745.1 - 3.4e-06 26.4 0.0 5.7e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.12 AIC14745.1 - 4.5e-06 26.0 0.3 1.1e-05 24.7 0.0 1.8 2 0 0 2 2 2 1 PcrB family Ribul_P_3_epim PF00834.14 AIC14745.1 - 0.00033 19.8 0.0 0.00071 18.7 0.0 1.6 2 0 0 2 2 2 1 Ribulose-phosphate 3 epimerase family NanE PF04131.9 AIC14745.1 - 0.0045 15.9 0.1 0.053 12.4 0.0 2.2 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.9 AIC14745.1 - 0.0049 15.9 0.1 0.011 14.7 0.1 1.6 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG Peripla_BP_4 PF13407.1 AIC14745.1 - 0.056 12.7 1.1 11 5.2 0.1 3.0 3 0 0 3 3 3 0 Periplasmic binding protein domain Pterin_bind PF00809.17 AIC14745.1 - 0.12 11.7 0.7 7.3 5.9 0.1 3.0 3 1 1 4 4 4 0 Pterin binding enzyme OMP_b-brl PF13505.1 AIC14745.1 - 0.13 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Outer membrane protein beta-barrel domain PALP PF00291.20 AIC14746.1 - 5.5e-40 137.4 0.3 6.9e-40 137.1 0.2 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF1863 PF08937.6 AIC14746.1 - 0.13 12.3 0.0 5 7.1 0.0 2.2 2 0 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) IGPS PF00218.16 AIC14747.1 - 9.5e-67 224.7 0.8 1.1e-66 224.4 0.5 1.0 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase NanE PF04131.9 AIC14747.1 - 0.00034 19.6 1.1 0.0012 17.7 0.8 1.9 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.16 AIC14747.1 - 0.0019 17.4 0.2 0.033 13.4 0.0 2.3 2 1 0 2 2 2 1 Histidine biosynthesis protein QRPTase_C PF01729.14 AIC14747.1 - 0.0062 16.0 0.0 0.012 15.1 0.0 1.4 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain ThiG PF05690.9 AIC14747.1 - 0.052 12.6 3.7 0.4 9.6 0.0 2.5 2 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG FMN_dh PF01070.13 AIC14747.1 - 0.077 11.8 0.2 3.5 6.3 0.0 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase PcrB PF01884.12 AIC14747.1 - 0.11 11.7 0.6 0.29 10.3 0.1 1.8 2 0 0 2 2 2 0 PcrB family AAA_22 PF13401.1 AIC14748.1 - 9.6e-11 41.9 0.2 3.6e-10 40.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 AIC14748.1 - 1.5e-07 31.6 0.1 5e-07 29.8 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA PF00004.24 AIC14748.1 - 6.5e-05 23.1 0.0 0.00019 21.6 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 AIC14748.1 - 0.00025 20.0 0.0 0.00043 19.2 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain Arch_ATPase PF01637.13 AIC14748.1 - 0.0003 20.5 1.1 0.00065 19.4 0.1 1.9 1 1 0 2 2 2 1 Archaeal ATPase NACHT PF05729.7 AIC14748.1 - 0.01 15.5 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_17 PF13207.1 AIC14748.1 - 0.023 15.4 0.4 3.3 8.5 0.0 3.0 3 0 0 3 3 3 0 AAA domain MarR_2 PF12802.2 AIC14748.1 - 0.067 12.8 1.0 0.24 11.1 0.1 2.3 2 0 0 2 2 2 0 MarR family SRP54 PF00448.17 AIC14748.1 - 0.098 12.0 0.6 0.21 11.0 0.4 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TrmB PF01978.14 AIC14749.1 - 0.01 15.5 0.0 0.017 14.8 0.0 1.4 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF977 PF06163.6 AIC14749.1 - 0.11 12.2 0.1 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) DUF1183 PF06682.7 AIC14750.1 - 0.12 11.9 0.1 0.12 11.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1183) Trypan_PARP PF05887.6 AIC14750.1 - 0.32 10.7 2.0 0.35 10.6 1.4 1.0 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF3628 PF12300.3 AIC14750.1 - 0.4 10.7 2.5 0.45 10.5 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3628) DUF3335 PF11814.3 AIC14751.1 - 0.062 12.4 0.0 0.21 10.6 0.0 1.8 2 0 0 2 2 2 0 Peptidase_C39 like family CTP_synth_N PF06418.9 AIC14752.1 - 3.9e-124 413.2 0.1 4.9e-124 412.8 0.1 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.23 AIC14752.1 - 4e-44 150.3 0.0 6.9e-44 149.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AIC14752.1 - 1.5e-10 40.8 0.0 2.6e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.18 AIC14752.1 - 7.5e-07 28.7 0.1 1.1e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ArgK PF03308.11 AIC14752.1 - 0.021 13.6 0.1 0.036 12.8 0.0 1.4 1 0 0 1 1 1 0 ArgK protein NAD_kinase PF01513.16 AIC14753.1 - 5.5e-34 117.2 0.3 7e-34 116.8 0.2 1.1 1 0 0 1 1 1 1 ATP-NAD kinase MarR_2 PF12802.2 AIC14753.1 - 0.00059 19.4 0.1 0.0011 18.5 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 AIC14753.1 - 0.00094 19.4 0.2 0.0021 18.3 0.1 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.17 AIC14753.1 - 0.0011 18.6 0.3 0.002 17.7 0.2 1.4 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC14753.1 - 0.017 14.8 0.2 0.049 13.3 0.1 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC14753.1 - 0.024 14.0 0.1 0.052 12.9 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding FeoC PF09012.5 AIC14753.1 - 0.049 13.3 0.1 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_9 PF08221.6 AIC14753.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain PfkB PF00294.19 AIC14754.1 - 4e-09 36.0 0.0 7.5e-09 35.1 0.0 1.4 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.7 AIC14754.1 - 0.035 13.2 0.0 0.046 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Ribosomal_S26e PF01283.14 AIC14755.1 - 3.4e-30 104.6 1.3 4e-30 104.3 0.9 1.0 1 0 0 1 1 1 1 Ribosomal protein S26e zf-dskA_traR PF01258.12 AIC14755.1 - 0.0085 15.8 0.1 0.79 9.5 0.0 2.3 2 0 0 2 2 2 1 Prokaryotic dksA/traR C4-type zinc finger DUF2112 PF09885.4 AIC14755.1 - 0.073 12.7 0.0 0.092 12.3 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2112) DZR PF12773.2 AIC14755.1 - 0.09 12.6 0.3 0.27 11.0 0.2 1.7 1 1 0 1 1 1 0 Double zinc ribbon Auto_anti-p27 PF06677.7 AIC14755.1 - 0.1 12.3 2.1 1.5 8.6 0.1 2.3 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Lar_restr_allev PF14354.1 AIC14755.1 - 0.14 12.4 1.1 1.6 9.1 0.0 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar RRN7 PF11781.3 AIC14755.1 - 0.23 11.0 2.7 2 8.0 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 CDP-OH_P_transf PF01066.16 AIC14756.1 - 2.2e-15 56.7 3.5 2.2e-15 56.7 2.4 1.5 2 0 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Response_reg PF00072.19 AIC14758.1 - 1.3e-13 50.9 0.1 2.4e-13 50.0 0.1 1.4 1 1 0 1 1 1 1 Response regulator receiver domain DUF3567 PF12091.3 AIC14758.1 - 0.09 12.7 0.1 0.59 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3567) HATPase_c PF02518.21 AIC14759.1 - 6.3e-23 80.6 0.0 1e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 AIC14759.1 - 6.4e-14 51.7 0.1 1.7e-13 50.3 0.1 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain MerC PF03203.9 AIC14759.1 - 0.025 14.9 3.3 0.058 13.7 1.7 2.1 1 1 1 2 2 2 0 MerC mercury resistance protein YtpI PF14007.1 AIC14759.1 - 8.5 6.3 10.3 0.22 11.4 0.2 3.0 3 0 0 3 3 3 0 YtpI-like protein GSDH PF07995.6 AIC14760.1 - 4.6e-48 164.0 0.1 5.4e-48 163.7 0.1 1.0 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Tachylectin PF14517.1 AIC14760.1 - 0.00053 19.3 0.1 0.011 15.0 0.0 2.3 2 0 0 2 2 2 1 Tachylectin Aldolase_II PF00596.16 AIC14761.1 - 2.2e-32 112.1 0.7 2.5e-32 111.9 0.5 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain ATP-synt_F PF01990.12 AIC14762.1 - 1.5e-17 63.7 0.0 1.6e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit DHquinase_I PF01487.10 AIC14762.1 - 0.057 13.0 0.0 0.061 12.9 0.0 1.1 1 0 0 1 1 1 0 Type I 3-dehydroquinase UBA PF00627.26 AIC14763.1 - 0.019 14.7 0.1 0.075 12.8 0.0 1.9 2 0 0 2 2 2 0 UBA/TS-N domain PrgI PF12666.2 AIC14764.1 - 0.028 14.5 0.5 0.028 14.5 0.3 1.0 1 0 0 1 1 1 0 PrgI family protein Srg PF02118.16 AIC14764.1 - 0.068 12.6 0.7 0.059 12.8 0.5 1.0 1 0 0 1 1 1 0 Srg family chemoreceptor ATPase_gene1 PF09527.5 AIC14764.1 - 0.088 12.6 0.1 0.092 12.5 0.1 1.2 1 0 0 1 1 1 0 Putative F0F1-ATPase subunit (ATPase_gene1) Myco_arth_vir_N PF09610.5 AIC14764.1 - 0.11 12.4 0.2 0.11 12.4 0.1 1.8 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) DUF4044 PF13253.1 AIC14764.1 - 1.4 8.1 3.8 2.4 7.4 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) SnoaL PF07366.7 AIC14765.1 - 4.7e-33 113.4 0.0 5.5e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.2 AIC14765.1 - 8.5e-21 74.2 0.0 1.1e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 AIC14765.1 - 0.059 13.5 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) PrgI PF12666.2 AIC14766.1 - 0.0049 16.9 0.3 0.0053 16.8 0.2 1.0 1 0 0 1 1 1 1 PrgI family protein DUF1049 PF06305.6 AIC14766.1 - 2.8 7.4 6.6 2.7 7.5 2.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1049) DnaJ PF00226.26 AIC14767.1 - 2.2e-26 91.3 3.9 3.5e-26 90.7 0.5 2.0 2 0 0 2 2 2 1 DnaJ domain DUF3273 PF11677.3 AIC14768.1 - 0.016 14.4 3.1 0.026 13.8 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3273) Abi PF02517.11 AIC14768.1 - 1.1 9.4 17.6 0.11 12.6 4.1 3.1 1 1 2 3 3 3 0 CAAX protease self-immunity Polyketide_cyc2 PF10604.4 AIC14769.1 - 4.7e-17 62.4 0.1 5.2e-17 62.3 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.6 AIC14769.1 - 1.2e-07 31.8 0.1 1.4e-07 31.6 0.0 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc PF03364.15 AIC14769.1 - 3.1e-06 27.1 0.0 3.9e-06 26.8 0.0 1.2 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport FixH PF05751.6 AIC14769.1 - 0.0095 15.7 0.0 0.012 15.4 0.0 1.1 1 0 0 1 1 1 1 FixH DUF4131 PF13567.1 AIC14770.1 - 0.045 13.1 0.0 0.081 12.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DUF972 PF06156.8 AIC14772.1 - 0.00012 22.3 10.9 0.036 14.3 2.4 2.6 1 1 1 2 2 2 2 Protein of unknown function (DUF972) TMF_TATA_bd PF12325.3 AIC14772.1 - 0.00017 21.2 11.6 0.0031 17.2 0.9 2.2 2 0 0 2 2 2 2 TATA element modulatory factor 1 TATA binding DUF904 PF06005.7 AIC14772.1 - 0.00028 21.0 14.5 0.1 12.9 4.2 3.2 1 1 2 3 3 3 2 Protein of unknown function (DUF904) APG6 PF04111.7 AIC14772.1 - 0.00051 19.1 15.7 0.011 14.8 4.4 2.1 1 1 1 2 2 2 2 Autophagy protein Apg6 CENP-F_leu_zip PF10473.4 AIC14772.1 - 0.00055 19.8 12.0 0.019 14.8 0.7 2.2 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HALZ PF02183.13 AIC14772.1 - 0.0012 18.4 19.7 0.38 10.4 5.1 5.0 4 2 1 5 5 4 1 Homeobox associated leucine zipper DUF4591 PF15261.1 AIC14772.1 - 0.0013 18.9 6.2 0.0024 18.1 4.3 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4591) TMF_DNA_bd PF12329.3 AIC14772.1 - 0.0014 18.3 16.8 0.044 13.5 0.8 3.1 3 0 0 3 3 3 2 TATA element modulatory factor 1 DNA binding DivIVA PF05103.8 AIC14772.1 - 0.0016 18.4 15.5 0.005 16.8 6.2 2.4 1 1 1 2 2 2 1 DivIVA protein Cep57_CLD_2 PF14197.1 AIC14772.1 - 0.0022 17.8 12.0 0.096 12.6 2.0 3.4 2 1 1 3 3 3 1 Centrosome localisation domain of PPC89 V_ATPase_I PF01496.14 AIC14772.1 - 0.0033 15.3 2.5 0.0041 15.0 1.7 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Kinesin-relat_1 PF12711.2 AIC14772.1 - 0.0039 17.5 10.2 0.034 14.5 1.2 3.7 1 1 3 4 4 4 1 Kinesin motor DUF4201 PF13870.1 AIC14772.1 - 0.004 16.5 6.0 0.55 9.6 0.6 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF4201) DivIC PF04977.10 AIC14772.1 - 0.0045 16.4 17.7 0.02 14.3 4.6 3.3 2 1 1 3 3 3 1 Septum formation initiator DUF2353 PF09789.4 AIC14772.1 - 0.0046 16.2 7.6 0.024 13.9 5.5 1.8 1 1 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) NYD-SP28_assoc PF14775.1 AIC14772.1 - 0.0063 16.1 9.4 1.3 8.8 0.1 4.2 3 1 1 4 4 4 1 Sperm tail C-terminal domain ATG16 PF08614.6 AIC14772.1 - 0.0072 16.1 15.6 0.03 14.1 8.6 2.0 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) bZIP_1 PF00170.16 AIC14772.1 - 0.013 15.3 17.0 0.34 10.9 0.5 4.3 2 2 1 4 4 4 0 bZIP transcription factor bZIP_2 PF07716.10 AIC14772.1 - 0.017 14.9 20.3 0.34 10.7 0.5 4.4 2 2 2 4 4 4 0 Basic region leucine zipper Laminin_I PF06008.9 AIC14772.1 - 0.038 13.2 13.2 0.12 11.6 1.9 2.2 2 0 0 2 2 2 0 Laminin Domain I CCDC155 PF14662.1 AIC14772.1 - 0.041 13.4 15.1 0.16 11.5 5.7 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 Golgin_A5 PF09787.4 AIC14772.1 - 0.046 12.2 14.8 0.042 12.3 2.6 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF3573 PF12097.3 AIC14772.1 - 0.06 11.9 3.7 0.11 11.1 1.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) Takusan PF04822.8 AIC14772.1 - 0.071 12.8 2.6 0.36 10.6 0.1 2.3 2 1 0 2 2 2 0 Takusan TLE_N PF03920.10 AIC14772.1 - 0.075 12.8 3.8 0.22 11.3 0.6 2.6 1 1 2 3 3 3 0 Groucho/TLE N-terminal Q-rich domain MAD PF05557.8 AIC14772.1 - 0.076 11.1 13.3 0.077 11.0 1.2 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein THOC7 PF05615.8 AIC14772.1 - 0.097 12.9 10.6 0.26 11.5 2.4 2.7 1 1 1 2 2 2 0 Tho complex subunit 7 GAS PF13851.1 AIC14772.1 - 0.1 11.7 13.1 0.85 8.7 8.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Med21 PF11221.3 AIC14772.1 - 0.15 12.0 0.2 0.15 12.0 0.2 2.8 1 1 0 2 2 2 0 Subunit 21 of Mediator complex CcmH PF03918.9 AIC14772.1 - 0.16 10.9 6.4 2.5 7.0 0.4 2.2 1 1 1 2 2 2 0 Cytochrome C biogenesis protein DUF342 PF03961.8 AIC14772.1 - 0.16 10.3 5.5 0.24 9.7 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Myosin_tail_1 PF01576.14 AIC14772.1 - 0.17 9.6 14.9 0.3 8.7 10.4 1.4 1 1 0 1 1 1 0 Myosin tail ADIP PF11559.3 AIC14772.1 - 0.17 11.7 15.0 1.4 8.7 1.8 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Hormone_1 PF00103.15 AIC14772.1 - 0.18 11.1 2.6 0.28 10.4 0.3 2.0 2 0 0 2 2 2 0 Somatotropin hormone family DUF848 PF05852.6 AIC14772.1 - 0.24 11.2 8.6 0.1 12.4 1.8 2.2 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Rab5-bind PF09311.6 AIC14772.1 - 0.25 11.2 13.7 0.62 9.9 3.3 2.9 1 1 2 3 3 3 0 Rabaptin-like protein DUF4618 PF15397.1 AIC14772.1 - 0.31 10.3 8.0 2.6 7.2 4.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) HAP1_N PF04849.8 AIC14772.1 - 0.32 9.8 9.2 1.5 7.7 6.3 2.0 1 1 0 1 1 1 0 HAP1 N-terminal conserved region CtIP_N PF10482.4 AIC14772.1 - 0.32 10.7 7.4 1.2 8.9 0.9 2.8 2 1 1 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain IncA PF04156.9 AIC14772.1 - 0.33 10.5 14.0 3.6 7.1 9.7 2.0 1 1 0 1 1 1 0 IncA protein TBPIP PF07106.8 AIC14772.1 - 0.35 10.3 12.0 1.7 8.1 2.9 2.3 1 1 2 3 3 3 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) TSC22 PF01166.13 AIC14772.1 - 0.45 10.5 7.6 24 4.9 2.1 3.8 1 1 3 4 4 3 0 TSC-22/dip/bun family HAUS6_N PF14661.1 AIC14772.1 - 0.52 9.6 16.0 0.26 10.6 3.0 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Gly-rich_Ago1 PF12764.2 AIC14772.1 - 0.62 10.7 5.1 0.49 11.0 1.5 2.0 2 0 0 2 2 2 0 Glycine-rich region of argonaut Rootletin PF15035.1 AIC14772.1 - 0.63 10.0 14.2 4.5 7.1 0.2 3.0 1 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.6 AIC14772.1 - 0.71 8.4 7.9 0.36 9.4 0.9 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein FlaC_arch PF05377.6 AIC14772.1 - 0.75 9.7 6.4 1.3 8.9 1.5 3.2 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) NTR2 PF15458.1 AIC14772.1 - 0.85 8.8 11.2 0.19 10.9 4.7 2.0 1 1 1 2 2 2 0 Nineteen complex-related protein 2 BLOC1_2 PF10046.4 AIC14772.1 - 1 9.5 7.4 0.27 11.3 0.8 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ERM PF00769.14 AIC14772.1 - 1.5 8.2 17.0 1 8.8 9.8 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family PilJ PF13675.1 AIC14772.1 - 1.6 9.0 12.2 1.7 8.9 4.9 2.5 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Shugoshin_N PF07558.6 AIC14772.1 - 2 8.2 5.1 18 5.1 0.0 3.2 2 2 2 4 4 3 0 Shugoshin N-terminal coiled-coil region DUF2570 PF10828.3 AIC14772.1 - 2 8.0 11.7 14 5.3 0.1 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) Bap31 PF05529.7 AIC14772.1 - 2.3 7.6 15.3 0.44 9.9 1.1 2.2 1 1 1 2 2 2 0 B-cell receptor-associated protein 31-like DMPK_coil PF08826.5 AIC14772.1 - 2.6 8.0 11.1 0.27 11.1 2.7 2.8 3 0 0 3 3 2 0 DMPK coiled coil domain like YlqD PF11068.3 AIC14772.1 - 2.7 8.0 9.8 60 3.6 6.8 2.1 1 1 0 1 1 1 0 YlqD protein KfrA_N PF11740.3 AIC14772.1 - 2.8 8.4 24.1 0.54 10.7 9.2 2.2 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term DASH_Dad3 PF08656.5 AIC14772.1 - 2.8 7.6 7.9 1 9.0 0.3 2.9 3 0 0 3 3 2 0 DASH complex subunit Dad3 DUF3450 PF11932.3 AIC14772.1 - 3.1 7.0 18.0 4 6.6 3.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) GreA_GreB_N PF03449.10 AIC14772.1 - 3.2 7.8 8.6 4.5 7.3 1.2 3.6 2 2 1 3 3 3 0 Transcription elongation factor, N-terminal Mto2_bdg PF12808.2 AIC14772.1 - 3.5 7.8 14.6 10 6.3 1.9 4.2 4 1 0 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region TPR_MLP1_2 PF07926.7 AIC14772.1 - 3.5 7.3 20.2 2.8 7.7 7.4 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Mnd1 PF03962.10 AIC14772.1 - 3.5 7.2 13.3 5.6 6.5 1.4 2.1 1 1 1 2 2 2 0 Mnd1 family Seryl_tRNA_N PF02403.17 AIC14772.1 - 3.6 7.6 13.3 20 5.2 0.3 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Prefoldin_2 PF01920.15 AIC14772.1 - 4.5 7.0 11.8 11 5.8 0.1 3.2 2 2 1 3 3 3 0 Prefoldin subunit Nnf1 PF03980.9 AIC14772.1 - 6 6.8 12.2 5.9 6.9 0.8 3.5 1 1 3 4 4 4 0 Nnf1 DUF3584 PF12128.3 AIC14772.1 - 6.2 4.0 15.7 7.6 3.7 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CENP-H PF05837.7 AIC14772.1 - 6.6 6.9 12.1 2.3 8.4 2.2 2.5 1 1 1 3 3 3 0 Centromere protein H (CENP-H) Tropomyosin_1 PF12718.2 AIC14772.1 - 7.2 6.4 16.2 0.38 10.5 3.9 2.4 2 1 0 2 2 2 0 Tropomyosin like Reo_sigmaC PF04582.7 AIC14772.1 - 7.6 5.6 8.7 6.8 5.7 1.3 2.2 1 1 1 2 2 2 0 Reovirus sigma C capsid protein FdhE PF04216.7 AIC14772.1 - 7.9 6.0 14.9 8.5 5.9 9.4 1.6 1 1 1 2 2 2 0 Protein involved in formate dehydrogenase formation EMP24_GP25L PF01105.19 AIC14772.1 - 9.2 5.9 7.2 2.1 8.0 0.2 2.1 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD AAA_13 PF13166.1 AIC14772.1 - 9.6 4.5 11.1 15 3.8 7.7 1.3 1 1 0 1 1 1 0 AAA domain DUF3275 PF11679.3 AIC14772.1 - 9.8 5.7 7.8 4.8 6.7 2.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3275) Prok-RING_1 PF14446.1 AIC14773.1 - 0.012 15.3 2.5 0.016 14.8 1.7 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_2 PF13639.1 AIC14773.1 - 0.012 15.3 2.5 0.017 14.9 1.7 1.2 1 0 0 1 1 1 0 Ring finger domain C1_1 PF00130.17 AIC14773.1 - 0.03 14.0 3.6 0.042 13.5 2.5 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2180 PF09947.4 AIC14773.1 - 0.052 13.2 1.3 0.063 13.0 0.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2180) zf-U1 PF06220.7 AIC14773.1 - 0.066 12.7 0.6 0.12 11.9 0.4 1.5 1 0 0 1 1 1 0 U1 zinc finger PHF5 PF03660.9 AIC14773.1 - 0.085 12.9 1.1 0.11 12.5 0.8 1.2 1 0 0 1 1 1 0 PHF5-like protein PHD PF00628.24 AIC14773.1 - 0.097 12.3 4.1 0.13 11.9 2.8 1.2 1 0 0 1 1 1 0 PHD-finger RINGv PF12906.2 AIC14773.1 - 0.26 11.3 3.7 0.44 10.6 2.5 1.4 1 0 0 1 1 1 0 RING-variant domain zf-met PF12874.2 AIC14773.1 - 7.5 6.9 6.2 18 5.7 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger of C2H2 type PDH PF02153.12 AIC14774.1 - 3.9e-17 61.9 0.5 5.5e-17 61.5 0.4 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.10 AIC14774.1 - 2.5e-06 27.4 0.2 4.9e-06 26.4 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 AIC14774.1 - 3.5e-05 24.1 0.3 0.00016 22.0 0.1 2.3 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent CoA_binding_2 PF13380.1 AIC14774.1 - 9.4e-05 22.5 0.2 0.00021 21.4 0.1 1.7 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.14 AIC14774.1 - 0.0002 21.7 0.9 0.00059 20.2 0.2 2.0 2 0 0 2 2 2 1 CoA binding domain NAD_Gly3P_dh_N PF01210.18 AIC14774.1 - 0.00021 21.0 2.6 0.0026 17.4 0.5 2.4 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Rossmann-like PF10727.4 AIC14774.1 - 0.00075 19.2 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 Rossmann-like domain DapB_N PF01113.15 AIC14774.1 - 0.0021 17.9 0.1 0.0053 16.6 0.1 1.8 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus IlvN PF07991.7 AIC14774.1 - 0.0041 16.4 0.1 0.048 13.0 0.0 2.1 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain GFO_IDH_MocA PF01408.17 AIC14774.1 - 0.0075 16.7 0.5 0.038 14.5 0.2 2.3 2 1 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold ApbA_C PF08546.6 AIC14774.1 - 0.016 15.1 0.1 0.041 13.8 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Ldh_1_N PF00056.18 AIC14774.1 - 0.049 13.4 0.6 1.2 8.9 0.4 2.6 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain ApbA PF02558.11 AIC14774.1 - 0.049 13.0 0.4 0.36 10.2 0.3 2.2 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Strep_pep PF14404.1 AIC14774.1 - 0.14 12.3 0.9 10 6.3 0.1 2.9 2 1 1 3 3 3 0 Ribosomally synthesized peptide in Streptomyces species Semialdhyde_dh PF01118.19 AIC14774.1 - 0.17 12.2 1.2 1.5 9.1 0.8 2.4 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Aminotran_1_2 PF00155.16 AIC14775.1 - 5.6e-52 176.8 0.0 7.2e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II CM_2 PF01817.16 AIC14775.1 - 4.3e-10 39.5 3.0 1.1e-09 38.2 2.1 1.7 1 0 0 1 1 1 1 Chorismate mutase type II Aminotran_5 PF00266.14 AIC14775.1 - 4.3e-10 38.8 0.0 6.6e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 AIC14775.1 - 1.8e-09 36.3 0.0 2.5e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.16 AIC14775.1 - 9.1e-09 34.8 0.0 6.3e-08 32.0 0.0 2.1 2 0 0 2 2 2 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 AIC14775.1 - 0.00011 21.4 0.3 0.00028 20.0 0.0 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Chorismate_synt PF01264.16 AIC14776.1 - 8.8e-140 465.0 0.0 1e-139 464.8 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase EPSP_synthase PF00275.15 AIC14777.1 - 4.5e-107 358.0 0.1 5.3e-107 357.8 0.1 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) GHMP_kinases_N PF00288.21 AIC14778.1 - 1.8e-11 43.9 0.7 5.2e-11 42.4 0.5 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 AIC14778.1 - 1.6e-05 24.9 0.1 5.1e-05 23.3 0.1 1.9 2 0 0 2 2 2 1 GHMP kinases C terminal Shikimate_dh_N PF08501.6 AIC14779.1 - 1.6e-31 108.2 0.0 4.2e-31 106.8 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain Shikimate_DH PF01488.15 AIC14779.1 - 2.2e-15 56.9 0.0 4e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 AIC14779.1 - 0.0001 21.4 1.2 0.00014 20.9 0.3 1.8 2 1 0 2 2 2 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 AIC14779.1 - 0.01 16.2 1.5 0.014 15.7 0.4 1.7 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DHquinase_I PF01487.10 AIC14780.1 - 1.1e-49 169.1 0.0 1.2e-49 168.9 0.0 1.0 1 0 0 1 1 1 1 Type I 3-dehydroquinase zf-C2H2 PF00096.21 AIC14781.1 - 2.1e-05 24.5 0.3 3.6e-05 23.8 0.2 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AIC14781.1 - 0.00029 20.9 0.3 0.00045 20.3 0.2 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger UPF0547 PF10571.4 AIC14781.1 - 0.0018 17.9 0.0 0.0022 17.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 zf-C2H2_jaz PF12171.3 AIC14781.1 - 0.0021 18.1 0.1 0.0021 18.1 0.0 1.5 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.2 AIC14781.1 - 0.0034 17.5 0.1 0.0066 16.6 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_6 PF13912.1 AIC14781.1 - 0.0052 16.6 0.5 0.0091 15.8 0.3 1.5 1 1 0 1 1 1 1 C2H2-type zinc finger zf-Di19 PF05605.7 AIC14781.1 - 0.082 13.0 0.5 0.098 12.8 0.4 1.1 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-BED PF02892.10 AIC14781.1 - 0.23 11.2 0.8 0.23 11.2 0.6 1.3 1 1 0 1 1 1 0 BED zinc finger DUF1628 PF07790.6 AIC14782.1 - 0.0055 17.4 0.1 0.011 16.5 0.1 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF1628) DUF3268 PF11672.3 AIC14783.1 - 0.1 12.6 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3268) N6_N4_Mtase PF01555.13 AIC14784.1 - 4.1e-35 121.3 0.0 5e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 AIC14784.1 - 1.1e-10 41.5 0.0 0.00015 21.7 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.1 AIC14784.1 - 0.0002 20.9 0.0 0.0011 18.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14784.1 - 0.00066 20.1 0.0 0.12 12.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC14784.1 - 0.016 15.5 0.0 0.03 14.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 AIC14784.1 - 0.044 13.3 0.0 2.8 7.4 0.0 2.4 2 1 0 2 2 2 0 Putative RNA methylase family UPF0020 CMAS PF02353.15 AIC14784.1 - 0.084 11.9 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.2 AIC14784.1 - 0.097 13.2 0.0 0.21 12.1 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain MethyltransfD12 PF02086.10 AIC14784.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase DHQS PF01959.11 AIC14786.1 - 2.5e-113 378.3 1.2 2.9e-113 378.1 0.9 1.0 1 0 0 1 1 1 1 3-dehydroquinate synthase (EC 4.6.1.3) Helicase_RecD PF05127.9 AIC14786.1 - 0.063 12.9 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Helicase NMO PF03060.10 AIC14786.1 - 0.069 12.2 0.1 0.16 11.0 0.1 1.7 1 0 0 1 1 1 0 Nitronate monooxygenase DeoC PF01791.4 AIC14787.1 - 4.5e-47 160.3 0.0 5.2e-47 160.1 0.0 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase PEP_mutase PF13714.1 AIC14787.1 - 0.0021 17.3 0.2 0.057 12.6 0.1 2.1 1 1 1 2 2 2 1 Phosphoenolpyruvate phosphomutase ThiG PF05690.9 AIC14787.1 - 0.009 15.1 0.8 0.009 15.1 0.6 2.6 3 1 0 3 3 3 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 AIC14787.1 - 0.024 13.9 0.1 0.1 11.8 0.0 1.9 2 0 0 2 2 2 0 Histidine biosynthesis protein DUF561 PF04481.7 AIC14787.1 - 0.081 11.8 0.0 0.12 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) V4R PF02830.13 AIC14788.1 - 7.4e-09 35.3 0.5 1.2e-08 34.6 0.3 1.4 1 0 0 1 1 1 1 V4R domain AP_endonuc_2 PF01261.19 AIC14790.1 - 1.2e-31 109.6 0.0 1.5e-31 109.3 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DNA_primase_lrg PF04104.9 AIC14791.1 - 7.4e-29 100.8 0.0 1.4e-28 99.9 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit EzrA PF06160.7 AIC14791.1 - 0.11 10.7 0.0 0.16 10.1 0.0 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA DNA_primase_S PF01896.14 AIC14792.1 - 1e-14 54.5 0.0 2.3e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase small subunit FAM72 PF14976.1 AIC14792.1 - 0.08 12.7 0.4 0.15 11.9 0.3 1.4 1 0 0 1 1 1 0 FAM72 protein OrfB_Zn_ribbon PF07282.6 AIC14792.1 - 0.094 12.3 2.7 0.095 12.3 0.7 1.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Zn_Tnp_IS1595 PF12760.2 AIC14792.1 - 0.64 9.8 3.3 1.6 8.6 2.3 1.7 1 0 0 1 1 1 0 Transposase zinc-ribbon domain UPF0182 PF03699.8 AIC14793.1 - 1.5e-33 115.7 15.2 4.4e-20 71.2 0.4 3.4 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0182) GATase PF00117.23 AIC14794.1 - 8.2e-23 80.8 0.0 9.6e-23 80.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AIC14794.1 - 5.5e-11 42.3 0.0 6e-10 38.9 0.0 2.0 1 1 0 1 1 1 1 Peptidase C26 TPR_11 PF13414.1 AIC14795.1 - 2.9e-23 81.2 10.1 2.3e-11 43.1 2.6 2.4 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.1 AIC14795.1 - 2.3e-15 56.2 17.5 8.8e-10 38.3 0.9 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 AIC14795.1 - 4.6e-15 55.8 13.0 8.1e-07 29.5 0.2 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.23 AIC14795.1 - 2.1e-13 49.2 12.3 2.5e-05 23.6 1.3 5.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.12 AIC14795.1 - 3.5e-13 48.3 11.0 0.0013 18.4 1.1 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.1 AIC14795.1 - 1.2e-11 43.8 7.4 2e-05 24.3 0.8 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.1 AIC14795.1 - 7.9e-10 38.9 8.8 6.6e-05 23.1 0.3 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.1 AIC14795.1 - 1.3e-09 37.8 9.9 0.00015 22.0 1.4 4.3 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.1 AIC14795.1 - 7.2e-09 34.7 8.5 0.0018 17.9 2.8 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.1 AIC14795.1 - 7.6e-08 32.1 2.8 5.4e-06 26.1 0.0 2.9 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.1 AIC14795.1 - 3.9e-07 29.3 6.7 0.23 11.3 0.0 4.4 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.1 AIC14795.1 - 0.00087 19.5 10.9 3.9 8.1 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat Peptidase_C39 PF03412.10 AIC14795.1 - 0.0009 19.0 0.0 0.0018 18.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase C39 family TPR_20 PF14561.1 AIC14795.1 - 0.0048 16.9 5.2 0.027 14.5 0.6 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat Peptidase_C39_2 PF13529.1 AIC14795.1 - 0.011 16.1 0.2 0.03 14.6 0.0 1.8 2 0 0 2 2 2 0 Peptidase_C39 like family Transpep_BrtH PF14399.1 AIC14795.1 - 0.05 12.9 0.9 0.61 9.3 0.0 2.8 1 1 0 2 2 2 0 NlpC/p60-like transpeptidase TPR_10 PF13374.1 AIC14795.1 - 0.14 12.1 7.0 10 6.2 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.7 AIC14795.1 - 0.96 10.1 10.2 2.5 8.8 2.5 3.6 3 0 0 3 3 3 0 Sel1 repeat ABM PF03992.11 AIC14796.1 - 1.4e-17 63.4 0.0 2.3e-17 62.8 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Clathrin_bdg PF15045.1 AIC14798.1 - 0.13 11.7 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking Aldo_ket_red PF00248.16 AIC14800.1 - 2.4e-32 111.8 0.0 3.8e-32 111.2 0.0 1.3 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_45 PF14947.1 AIC14802.1 - 6.7e-12 45.0 0.0 9.6e-12 44.5 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DUF2513 PF10711.4 AIC14802.1 - 0.0021 18.1 0.1 0.0048 16.9 0.0 1.6 1 1 0 1 1 1 1 Hypothetical protein (DUF2513) Rio2_N PF09202.6 AIC14802.1 - 0.011 15.7 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 0 Rio2, N-terminal AAA_assoc_C PF09821.4 AIC14802.1 - 0.069 13.4 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 C-terminal AAA-associated domain TrmB PF01978.14 AIC14802.1 - 0.1 12.3 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.1 AIC14802.1 - 0.11 12.5 0.0 1.1 9.3 0.0 2.0 1 1 0 1 1 1 0 Winged helix DNA-binding domain DUF4394 PF14339.1 AIC14803.1 - 0.00062 19.1 3.2 0.0043 16.3 0.4 2.9 1 1 2 3 3 3 1 Domain of unknown function (DUF4394) Pep3_Vps18 PF05131.9 AIC14803.1 - 0.013 14.9 0.0 0.03 13.7 0.0 1.6 1 0 0 1 1 1 0 Pep3/Vps18/deep orange family PQQ_3 PF13570.1 AIC14803.1 - 0.44 10.9 9.2 0.31 11.3 0.2 4.2 4 1 0 4 4 4 0 PQQ-like domain LT-IIB PF06453.6 AIC14803.1 - 0.44 10.2 13.0 9.2 5.9 0.2 4.2 2 2 2 4 4 4 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) Reprolysin_5 PF13688.1 AIC14805.1 - 0.00014 21.8 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Metallopep PF12044.3 AIC14805.1 - 0.00046 18.7 0.0 0.00056 18.4 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_3 PF13582.1 AIC14805.1 - 0.0016 18.9 0.8 0.0029 18.1 0.5 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin PF01421.14 AIC14805.1 - 0.0018 17.8 0.0 0.0024 17.5 0.0 1.1 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M66 PF10462.4 AIC14805.1 - 0.0085 14.9 0.8 0.013 14.3 0.6 1.2 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_2 PF13574.1 AIC14805.1 - 0.013 15.5 0.2 0.025 14.6 0.0 1.6 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M43 PF05572.8 AIC14805.1 - 0.041 13.4 0.1 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Pregnancy-associated plasma protein-A Reprolysin_4 PF13583.1 AIC14805.1 - 0.059 12.8 0.1 0.097 12.1 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M10 PF00413.19 AIC14805.1 - 0.076 12.7 0.2 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Matrixin CHU_C PF13585.1 AIC14808.1 - 0.0059 16.4 4.4 3.6 7.5 0.3 3.7 3 0 0 3 3 3 2 C-terminal domain of CHU protein family UbiA PF01040.13 AIC14809.1 - 2.5e-31 108.8 24.0 3.3e-31 108.4 16.7 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family DUF3989 PF13150.1 AIC14809.1 - 0.43 10.0 1.5 1.1 8.7 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) AsnC_trans_reg PF01037.16 AIC14810.1 - 3.6e-10 39.3 0.0 4e-10 39.2 0.0 1.0 1 0 0 1 1 1 1 AsnC family ACT_4 PF13291.1 AIC14810.1 - 0.027 14.7 0.1 6.3 7.2 0.0 2.1 2 0 0 2 2 2 0 ACT domain DUF2203 PF09969.4 AIC14811.1 - 6.9e-35 119.8 0.1 8e-35 119.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) Na_H_Exchanger PF00999.16 AIC14812.1 - 3.8e-70 236.3 48.4 4.5e-70 236.0 33.5 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family GDE_C PF06202.9 AIC14813.1 - 5.5e-38 130.6 0.1 1e-37 129.7 0.0 1.5 1 1 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Bac_rhamnosid PF05592.6 AIC14813.1 - 4e-11 41.8 0.1 6e-11 41.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase Glyco_hydro_100 PF12899.2 AIC14813.1 - 1.9e-08 33.1 0.1 0.00097 17.6 0.0 2.3 2 0 0 2 2 2 2 Alkaline and neutral invertase DUF608 PF04685.8 AIC14813.1 - 3.1e-06 26.1 2.1 1.7e-05 23.7 1.6 2.0 2 1 0 2 2 2 1 Protein of unknown function, DUF608 Trehalase PF01204.13 AIC14813.1 - 1.6e-05 23.7 0.3 4.2e-05 22.3 0.0 1.7 2 0 0 2 2 2 1 Trehalase Type_III_YscG PF09477.5 AIC14813.1 - 0.0018 18.3 0.0 0.0057 16.7 0.0 1.8 2 0 0 2 2 2 1 Bacterial type II secretion system chaperone protein (type_III_yscG) Glyco_transf_36 PF06165.6 AIC14813.1 - 0.14 12.0 0.0 0.35 10.7 0.0 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 36 Osmo_MPGsynth PF09488.5 AIC14814.1 - 5.9e-156 518.9 0.0 6.7e-156 518.7 0.0 1.0 1 0 0 1 1 1 1 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) Zn_Tnp_IS1595 PF12760.2 AIC14815.1 - 0.023 14.5 0.4 0.039 13.7 0.3 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.7 AIC14815.1 - 0.038 13.2 5.7 0.07 12.4 4.0 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding C1_2 PF03107.11 AIC14815.1 - 0.079 13.0 2.6 0.079 13.0 1.8 1.6 2 0 0 2 2 2 0 C1 domain PSCyt3 PF07627.6 AIC14815.1 - 0.1 12.5 1.0 0.11 12.3 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) Elf1 PF05129.8 AIC14815.1 - 0.23 11.1 2.2 0.5 10.0 1.5 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like TFIIS_C PF01096.13 AIC14815.1 - 0.28 10.8 4.1 7.2 6.3 0.1 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zinc_ribbon_5 PF13719.1 AIC14815.1 - 0.3 10.7 2.2 2 8.0 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC14815.1 - 0.33 10.6 2.4 1.8 8.3 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.7 AIC14815.1 - 0.4 10.5 4.1 0.82 9.4 2.1 1.7 1 1 0 1 1 1 0 zinc-ribbons Zn-ribbon_8 PF09723.5 AIC14815.1 - 0.54 10.2 4.7 2.5 8.1 0.2 2.3 2 0 0 2 2 2 0 Zinc ribbon domain Cytochrom_c3_2 PF14537.1 AIC14815.1 - 0.59 10.5 3.4 0.4 11.0 0.9 1.5 1 1 0 1 1 1 0 Cytochrome c3 DUF2387 PF09526.5 AIC14815.1 - 1 9.3 6.8 0.26 11.2 1.6 1.9 2 0 0 2 2 2 0 Probable metal-binding protein (DUF2387) C1_3 PF07649.7 AIC14815.1 - 4.7 7.3 9.8 0.13 12.3 2.3 1.7 2 0 0 2 2 2 0 C1-like domain UPF0086 PF01868.11 AIC14816.1 - 0.0011 18.5 0.1 0.066 12.8 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function UPF0086 DUF4147 PF13660.1 AIC14817.1 - 2.2e-81 272.4 2.3 3.2e-81 271.9 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.8 AIC14817.1 - 7e-33 112.9 0.9 1.4e-32 111.9 0.6 1.6 1 0 0 1 1 1 1 MOFRL family BPL_LplA_LipB PF03099.14 AIC14818.1 - 3.9e-19 68.8 0.0 8.5e-19 67.8 0.0 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family HTH_11 PF08279.7 AIC14818.1 - 1.4e-13 50.2 0.0 3e-13 49.1 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.1 AIC14818.1 - 1e-06 28.0 0.0 2e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding BPL_C PF02237.12 AIC14818.1 - 0.00023 20.8 0.1 0.00052 19.6 0.1 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain HTH_AsnC-type PF13404.1 AIC14818.1 - 0.0022 17.5 0.3 0.006 16.1 0.2 1.8 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_36 PF13730.1 AIC14818.1 - 0.0071 16.4 0.0 0.017 15.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.15 AIC14818.1 - 0.014 15.5 0.1 0.089 12.9 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulator Fe_dep_repress PF01325.14 AIC14818.1 - 0.015 15.2 0.0 0.033 14.1 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_1 PF00126.22 AIC14818.1 - 0.015 15.0 0.1 0.055 13.2 0.1 1.9 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family TrmB PF01978.14 AIC14818.1 - 0.064 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_10 PF04967.7 AIC14818.1 - 0.095 12.3 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 HTH DNA binding domain DUF2087 PF09860.4 AIC14819.1 - 0.0022 17.6 0.0 0.0039 16.9 0.0 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2087) MMR_HSR1_C PF08438.5 AIC14820.1 - 4.8e-34 116.8 0.0 1.4e-33 115.3 0.0 1.8 2 0 0 2 2 2 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 AIC14820.1 - 1.1e-16 60.8 0.0 3.6e-16 59.1 0.0 1.9 3 0 0 3 3 3 1 50S ribosome-binding GTPase TGS PF02824.16 AIC14820.1 - 2.3e-10 40.1 0.0 4.4e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.13 AIC14820.1 - 9.2e-08 31.5 0.1 4.7e-06 25.9 0.2 2.9 2 1 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.18 AIC14820.1 - 0.00017 21.4 0.0 0.043 13.6 0.0 2.4 1 1 0 2 2 2 2 Dynamin family GTP_EFTU PF00009.22 AIC14820.1 - 0.0036 16.7 0.2 1.4 8.2 0.1 2.6 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Imm31 PF15595.1 AIC14824.1 - 0.054 13.2 0.0 0.085 12.6 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 31 Erythro-docking PF09277.6 AIC14824.1 - 0.65 9.7 3.3 0.65 9.7 0.1 2.4 2 1 1 3 3 3 0 Erythronolide synthase, docking zf-C3HC4_3 PF13920.1 AIC14828.1 - 0.053 13.1 1.9 0.088 12.4 1.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) EFG_II PF14492.1 AIC14828.1 - 0.076 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Elongation Factor G, domain II zf-C2H2_2 PF12756.2 AIC14828.1 - 0.67 10.0 0.0 0.67 10.0 0.0 2.3 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) MEDS PF14417.1 AIC14829.1 - 0.0026 16.8 0.0 0.0093 15.0 0.0 2.0 1 1 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain CoA_binding_2 PF13380.1 AIC14830.1 - 8.3e-38 129.1 0.2 9.5e-38 128.9 0.2 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.14 AIC14830.1 - 7.3e-08 32.8 0.4 1.4e-07 31.9 0.1 1.5 2 0 0 2 2 2 1 CoA binding domain TroA PF01297.12 AIC14830.1 - 0.0049 16.1 0.0 0.009 15.2 0.0 1.4 2 0 0 2 2 2 1 Periplasmic solute binding protein family DAHP_synth_2 PF01474.11 AIC14830.1 - 0.093 11.0 0.0 0.12 10.7 0.0 1.1 1 0 0 1 1 1 0 Class-II DAHP synthetase family HEPN PF05168.9 AIC14831.1 - 4.9e-06 26.4 1.2 9.8e-06 25.4 0.8 1.5 1 0 0 1 1 1 1 HEPN domain DUF4285 PF14113.1 AIC14831.1 - 0.13 12.2 0.1 0.95 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4285) Collar PF07484.7 AIC14832.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Phage Tail Collar Domain SHOCT PF09851.4 AIC14833.1 - 1.3e-06 27.6 3.7 2.2e-06 26.9 1.4 2.2 2 0 0 2 2 2 1 Short C-terminal domain GRAM PF02893.15 AIC14833.1 - 0.00025 20.5 0.0 0.00065 19.1 0.0 1.7 1 0 0 1 1 1 1 GRAM domain DUF4428 PF14471.1 AIC14833.1 - 0.00095 18.8 6.2 0.3 10.8 0.2 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4428) Vps36_ESCRT-II PF11605.3 AIC14833.1 - 0.024 14.4 0.0 0.066 13.0 0.0 1.8 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 Cytochrome_C7 PF14522.1 AIC14833.1 - 0.045 13.3 4.9 0.16 11.6 0.3 2.4 2 0 0 2 2 2 0 Cytochrome c7 GvpG PF05120.7 AIC14833.1 - 0.051 13.3 0.2 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 Gas vesicle protein G Cytochrom_c3_2 PF14537.1 AIC14833.1 - 0.068 13.5 5.0 0.17 12.2 0.3 2.4 2 0 0 2 2 2 0 Cytochrome c3 Paired_CXXCH_1 PF09699.5 AIC14833.1 - 0.14 11.7 4.4 0.29 10.6 0.8 2.5 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrome_C554 PF13435.1 AIC14833.1 - 0.4 10.7 3.7 0.71 9.9 0.4 2.4 2 0 0 2 2 2 0 Cytochrome c554 and c-prime FYVE_2 PF02318.11 AIC14833.1 - 0.81 9.6 4.2 5 7.0 0.2 2.4 2 0 0 2 2 2 0 FYVE-type zinc finger GATase_2 PF00310.16 AIC14836.1 - 1.9e-21 76.1 0.1 2e-10 39.9 0.0 3.1 2 1 0 3 3 3 3 Glutamine amidotransferases class-II GATase_6 PF13522.1 AIC14836.1 - 2.1e-15 56.8 0.0 4e-15 55.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.1 AIC14836.1 - 1.7e-13 50.3 0.0 3e-13 49.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.22 AIC14836.1 - 3.6e-10 39.6 0.1 8.3e-10 38.4 0.1 1.6 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.1 AIC14836.1 - 4e-06 25.7 0.0 6.2e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferases class-II AIRS_C PF02769.17 AIC14837.1 - 1.7e-45 154.7 0.7 1.5e-21 77.0 0.0 2.2 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.19 AIC14837.1 - 8.9e-39 131.6 3.5 5.5e-23 81.0 0.6 2.6 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain GATase_5 PF13507.1 AIC14838.1 - 6.9e-44 149.6 0.0 9.5e-44 149.2 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_3 PF07685.9 AIC14838.1 - 7.2e-09 35.4 0.0 3.4e-08 33.2 0.0 2.0 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.19 AIC14838.1 - 1.6e-08 34.1 0.0 6.5e-08 32.1 0.0 2.0 2 0 0 2 2 2 1 DJ-1/PfpI family GATase PF00117.23 AIC14838.1 - 8.5e-08 31.8 0.0 1.5e-07 31.1 0.0 1.4 1 1 0 1 1 1 1 Glutamine amidotransferase class-I DUF4066 PF13278.1 AIC14838.1 - 4.4e-05 22.8 0.0 0.00014 21.2 0.0 1.7 2 0 0 2 2 2 1 Putative amidotransferase SNO PF01174.14 AIC14838.1 - 0.00078 19.1 0.0 0.0025 17.4 0.0 1.7 1 1 0 1 1 1 1 SNO glutamine amidotransferase family Peptidase_C26 PF07722.8 AIC14838.1 - 0.0031 16.9 0.0 0.0062 16.0 0.0 1.6 1 0 0 1 1 1 1 Peptidase C26 CBS PF00571.23 AIC14839.1 - 2.6e-32 110.3 5.7 3.9e-17 61.7 0.1 2.6 3 0 0 3 3 3 2 CBS domain MAPKK1_Int PF08923.5 AIC14839.1 - 0.0059 16.2 0.1 0.0081 15.7 0.1 1.3 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting PurS PF02700.9 AIC14840.1 - 6.2e-19 67.7 0.3 7e-19 67.5 0.2 1.0 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase Cnd1 PF12717.2 AIC14840.1 - 0.033 14.0 0.0 0.036 13.9 0.0 1.0 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Nitroreductase PF00881.19 AIC14841.1 - 1.9e-22 79.8 0.0 2.6e-22 79.4 0.0 1.1 1 0 0 1 1 1 1 Nitroreductase family TIMP PF00965.12 AIC14843.1 - 0.0022 17.6 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase Gram_pos_anchor PF00746.16 AIC14843.1 - 0.01 15.5 2.2 0.023 14.4 1.5 1.6 1 0 0 1 1 1 0 Gram positive anchor MitoNEET_N PF10660.4 AIC14845.1 - 0.023 14.5 0.3 0.046 13.5 0.2 1.5 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Glycophorin_A PF01102.13 AIC14845.1 - 0.026 14.2 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A Bromo_TP PF07524.8 AIC14847.1 - 0.091 12.5 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Bromodomain associated DUF3566 PF12089.3 AIC14847.1 - 1.3 9.0 6.4 11 6.1 0.2 2.4 1 1 1 2 2 2 0 Transmembrane domain of unknown function (DUF3566) HTH_34 PF13601.1 AIC14848.1 - 0.00065 19.6 0.1 0.002 18.1 0.0 1.8 2 1 0 2 2 2 1 Winged helix DNA-binding domain HTH_45 PF14947.1 AIC14848.1 - 0.0027 17.4 0.4 0.022 14.5 0.3 2.0 1 1 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC14848.1 - 0.022 14.3 0.1 0.032 13.8 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4364) Mrr_N PF14338.1 AIC14848.1 - 0.024 14.7 0.0 0.27 11.3 0.0 2.0 1 1 1 2 2 2 0 Mrr N-terminal domain PadR PF03551.9 AIC14848.1 - 0.025 14.3 0.1 0.032 13.9 0.1 1.4 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family Phage_int_SAM_4 PF13495.1 AIC14848.1 - 0.036 14.4 0.1 0.14 12.5 0.0 1.9 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain HTH_36 PF13730.1 AIC14848.1 - 0.098 12.7 0.0 18 5.5 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain YjcQ PF09639.5 AIC14848.1 - 0.12 12.4 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 YjcQ protein ABC2_membrane PF01061.19 AIC14849.1 - 1.5e-16 60.1 23.3 2.2e-16 59.6 16.1 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 AIC14849.1 - 2.2e-10 40.1 25.0 4.1e-10 39.2 17.3 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein Phage_holin_1 PF04531.8 AIC14849.1 - 0.034 14.2 0.5 0.089 12.8 0.1 2.0 2 0 0 2 2 2 0 Bacteriophage holin ABC2_membrane_2 PF12679.2 AIC14849.1 - 5.4 5.7 23.4 0.31 9.8 11.1 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein ABC_tran PF00005.22 AIC14850.1 - 1.6e-27 96.4 0.0 2.3e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC14850.1 - 3.4e-09 37.1 0.0 4.8e-06 26.7 0.0 2.2 2 0 0 2 2 2 2 AAA domain UPF0079 PF02367.12 AIC14850.1 - 0.00024 20.7 0.0 0.00043 19.9 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 AIC14850.1 - 0.0018 17.7 0.2 0.0059 16.1 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain SMC_N PF02463.14 AIC14850.1 - 0.0045 16.2 0.0 0.1 11.7 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.1 AIC14850.1 - 0.013 15.4 0.0 0.11 12.4 0.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.1 AIC14850.1 - 0.013 15.0 0.0 0.2 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.1 AIC14850.1 - 0.024 14.5 0.0 0.043 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain MutS_V PF00488.16 AIC14850.1 - 0.035 13.4 0.0 0.69 9.2 0.0 2.1 2 0 0 2 2 2 0 MutS domain V SRP54 PF00448.17 AIC14850.1 - 0.047 13.1 0.1 0.085 12.2 0.1 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_22 PF13401.1 AIC14850.1 - 0.053 13.6 0.1 0.13 12.4 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA PF00004.24 AIC14850.1 - 0.11 12.7 0.0 0.21 11.7 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 AIC14850.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.1 AIC14850.1 - 0.15 12.3 0.0 0.27 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Peptidase_M50 PF02163.17 AIC14853.1 - 7.7e-30 103.2 0.0 2.7e-29 101.5 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M50 PDZ_2 PF13180.1 AIC14853.1 - 0.0048 16.7 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.1 AIC14853.1 - 0.0093 15.7 0.1 0.018 14.8 0.1 1.4 1 0 0 1 1 1 1 Tricorn protease PDZ domain VPS28 PF03997.7 AIC14854.1 - 0.033 13.8 0.1 0.034 13.7 0.1 1.0 1 0 0 1 1 1 0 VPS28 protein TIR_2 PF13676.1 AIC14855.1 - 2.5e-07 30.7 0.0 3.6e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 TIR domain DUF1863 PF08937.6 AIC14855.1 - 0.019 14.9 2.8 0.066 13.2 2.0 1.7 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) DUF4062 PF13271.1 AIC14855.1 - 0.03 14.3 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4062) HypA PF01155.14 AIC14855.1 - 0.32 10.6 1.6 0.58 9.8 1.1 1.3 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-IS66 PF13005.2 AIC14855.1 - 0.54 10.2 3.3 1.4 8.9 0.2 2.2 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 zf-ISL3 PF14690.1 AIC14855.1 - 7.5 6.6 9.5 0.33 10.9 0.3 2.8 2 1 0 3 3 3 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 HTH_45 PF14947.1 AIC14859.1 - 0.00033 20.4 0.0 0.00091 18.9 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_5 PF01022.15 AIC14859.1 - 0.0017 17.9 0.0 0.0041 16.7 0.0 1.7 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family TrbC_Ftype PF09673.5 AIC14859.1 - 0.051 13.1 0.0 0.094 12.3 0.0 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Glyco_hydro_4 PF02056.11 AIC14859.1 - 0.16 11.2 0.7 0.96 8.7 0.1 2.1 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase DDE_Tnp_IS240 PF13610.1 AIC14860.1 - 1.9e-16 60.2 0.6 6.3e-16 58.6 0.1 2.0 2 0 0 2 2 2 1 DDE domain DDE_Tnp_IS66 PF03050.9 AIC14860.1 - 1.7e-08 34.0 0.1 3.5e-08 33.0 0.1 1.5 1 1 0 1 1 1 1 Transposase IS66 family rve_3 PF13683.1 AIC14860.1 - 5.2e-07 29.0 0.0 2.6e-06 26.8 0.0 2.1 2 0 0 2 2 2 1 Integrase core domain rve PF00665.21 AIC14860.1 - 2.5e-06 27.5 0.1 5.8e-06 26.4 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain SWIM PF04434.12 AIC14860.1 - 0.00028 20.2 0.8 0.00069 19.0 0.6 1.6 1 0 0 1 1 1 1 SWIM zinc finger Transposase_mut PF00872.13 AIC14860.1 - 0.0087 14.6 0.1 0.061 11.8 0.1 2.0 2 0 0 2 2 2 1 Transposase, Mutator family Elf1 PF05129.8 AIC14860.1 - 0.024 14.3 0.9 0.065 12.9 0.6 1.7 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Rpr2 PF04032.11 AIC14860.1 - 0.088 12.6 2.1 0.31 10.9 1.5 1.9 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain Zn_Tnp_IS1595 PF12760.2 AIC14860.1 - 1.9 8.3 8.3 0.88 9.4 3.7 2.0 2 0 0 2 2 2 0 Transposase zinc-ribbon domain Zn_ribbon_recom PF13408.1 AIC14860.1 - 6.3 7.1 8.6 0.44 10.8 1.3 2.6 4 0 0 4 4 3 0 Recombinase zinc beta ribbon domain PHD PF00628.24 AIC14860.1 - 9.8 5.9 8.6 0.4 10.4 1.2 2.3 2 0 0 2 2 2 0 PHD-finger Beta-Casp PF10996.3 AIC14862.1 - 2.5e-27 95.3 0.0 4.8e-27 94.3 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.22 AIC14862.1 - 1.2e-16 60.8 0.1 3.4e-16 59.4 0.1 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.7 AIC14862.1 - 1.7e-14 53.3 0.0 3.6e-14 52.2 0.0 1.6 1 0 0 1 1 1 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_2 PF12706.2 AIC14862.1 - 1.4e-12 47.6 0.1 4.1e-10 39.5 0.0 2.5 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 AIC14862.1 - 0.022 14.4 0.0 0.058 13.0 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain PhageMin_Tail PF10145.4 AIC14865.1 - 0.00079 19.1 3.0 0.0013 18.4 2.1 1.4 1 1 0 1 1 1 1 Phage-related minor tail protein Talin_middle PF09141.5 AIC14865.1 - 0.0069 16.0 1.0 0.0069 16.0 0.7 1.6 2 0 0 2 2 2 1 Talin, middle domain DUF2203 PF09969.4 AIC14865.1 - 0.007 16.5 4.7 0.078 13.2 0.2 2.2 1 1 1 2 2 2 2 Uncharacterized conserved protein (DUF2203) Amidohydro_2 PF04909.9 AIC14865.1 - 0.062 12.8 3.4 0.061 12.8 1.4 1.6 1 1 1 2 2 2 0 Amidohydrolase HisKA_3 PF07730.8 AIC14865.1 - 0.12 12.7 0.1 0.12 12.7 0.1 4.1 1 1 1 2 2 2 0 Histidine kinase RuvA_C PF07499.8 AIC14865.1 - 0.13 12.4 1.8 0.22 11.7 0.1 2.2 2 0 0 2 2 2 0 RuvA, C-terminal domain UPF0147 PF03685.8 AIC14866.1 - 2.8e-22 78.3 3.4 3.3e-22 78.1 2.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0147) DUF1216 PF06746.6 AIC14866.1 - 0.031 14.0 6.7 1.1 8.9 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1216) YtzH PF14165.1 AIC14866.1 - 0.089 13.0 2.4 0.67 10.2 0.9 2.3 1 1 1 2 2 2 0 YtzH-like protein DUF3461 PF11944.3 AIC14866.1 - 0.16 11.8 2.6 1.1 9.0 1.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) Rgp1 PF08737.5 AIC14866.1 - 0.37 9.8 4.1 0.42 9.6 2.8 1.1 1 0 0 1 1 1 0 Rgp1 Prp18 PF02840.10 AIC14866.1 - 0.72 9.6 4.6 0.94 9.2 1.6 1.8 1 1 1 2 2 2 0 Prp18 domain PadR PF03551.9 AIC14867.1 - 0.039 13.7 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_45 PF14947.1 AIC14867.1 - 0.077 12.8 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix AKAP95 PF04988.7 AIC14868.1 - 0.053 13.3 0.2 0.067 12.9 0.1 1.1 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Usp PF00582.21 AIC14869.1 - 6.4e-34 117.1 0.1 7.2e-34 116.9 0.0 1.0 1 0 0 1 1 1 1 Universal stress protein family PucR PF07905.6 AIC14869.1 - 0.00092 18.7 0.0 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 Purine catabolism regulatory protein-like family ETF PF01012.16 AIC14869.1 - 0.076 12.7 0.1 0.78 9.4 0.1 2.2 1 1 0 1 1 1 0 Electron transfer flavoprotein domain Na_Ca_ex PF01699.19 AIC14870.1 - 1.4e-26 92.8 30.4 2.7e-13 49.7 7.1 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Methyltransf_26 PF13659.1 AIC14871.1 - 0.00069 19.6 0.1 0.005 16.8 0.1 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14871.1 - 0.011 16.3 0.1 0.026 15.1 0.1 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.1 AIC14871.1 - 0.016 14.8 0.3 0.028 14.0 0.2 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 AIC14871.1 - 0.055 13.1 0.0 0.097 12.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 AIC14871.1 - 0.16 11.3 0.1 0.27 10.6 0.0 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Zn_Tnp_IS1595 PF12760.2 AIC14872.1 - 0.0021 17.8 1.6 0.0026 17.5 1.1 1.2 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DNA_RNApol_7kD PF03604.8 AIC14872.1 - 0.099 12.1 5.8 0.22 11.0 4.0 1.6 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Ribosomal_L37e PF01907.14 AIC14872.1 - 0.12 12.1 1.1 0.13 12.0 0.8 1.2 1 0 0 1 1 1 0 Ribosomal protein L37e Zn-ribbon_8 PF09723.5 AIC14872.1 - 0.22 11.5 1.9 0.37 10.7 0.2 1.9 2 0 0 2 2 2 0 Zinc ribbon domain DUF883 PF05957.8 AIC14873.1 - 0.067 13.6 4.2 0.077 13.4 2.9 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) MT0933_antitox PF14013.1 AIC14873.1 - 0.067 13.2 22.0 0.53 10.4 12.7 2.8 1 1 1 2 2 2 0 MT0933-like antitoxin protein SseC PF04888.7 AIC14873.1 - 0.083 12.2 9.6 0.083 12.2 6.7 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family ATP-synt_B PF00430.13 AIC14873.1 - 0.23 11.2 10.1 0.25 11.1 7.0 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) EAP30 PF04157.11 AIC14873.1 - 0.36 9.9 2.2 0.37 9.9 1.5 1.0 1 0 0 1 1 1 0 EAP30/Vps36 family YtxH PF12732.2 AIC14873.1 - 0.51 10.7 9.3 1.2 9.5 6.5 1.6 1 1 0 1 1 1 0 YtxH-like protein PAG PF15347.1 AIC14873.1 - 0.78 8.7 4.2 0.85 8.6 2.9 1.0 1 0 0 1 1 1 0 Phosphoprotein associated with glycosphingolipid-enriched Borrelia_P83 PF05262.6 AIC14873.1 - 1.5 7.0 11.6 1.6 6.9 8.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein ISG65-75 PF11727.3 AIC14873.1 - 1.9 7.4 11.0 2 7.3 7.6 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein Rotamase PF00639.16 AIC14873.1 - 2.9 8.6 6.7 3.4 8.4 4.7 1.1 1 0 0 1 1 1 0 PPIC-type PPIASE domain AgrB PF04647.10 AIC14875.1 - 0.015 14.3 0.0 0.017 14.1 0.0 1.0 1 0 0 1 1 1 0 Accessory gene regulator B Wzy_C PF04932.10 AIC14875.1 - 0.06 13.1 1.2 0.063 13.0 0.8 1.0 1 0 0 1 1 1 0 O-Antigen ligase VPEP PF07589.6 AIC14875.1 - 1.2 9.1 4.3 17 5.5 0.2 2.4 2 0 0 2 2 2 0 PEP-CTERM motif DUF2892 PF11127.3 AIC14875.1 - 2.4 8.0 5.3 3.2 7.6 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2892) CoA_binding PF02629.14 AIC14878.1 - 1.9e-20 73.1 0.5 5.8e-20 71.6 0.3 1.8 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.14 AIC14878.1 - 4.4e-09 36.1 0.0 7.7e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 CoA-ligase CoA_binding_2 PF13380.1 AIC14878.1 - 5.2e-05 23.3 0.0 0.00014 22.0 0.0 1.7 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.1 AIC14878.1 - 0.00012 21.7 0.0 0.00019 21.0 0.0 1.4 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain GFO_IDH_MocA PF01408.17 AIC14878.1 - 0.0051 17.3 0.0 0.014 15.8 0.0 1.7 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold ATP-grasp_2 PF08442.5 AIC14879.1 - 8.4e-40 136.3 0.1 1.5e-39 135.4 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.1 AIC14879.1 - 6.6e-14 51.6 0.1 7.4e-13 48.2 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.14 AIC14879.1 - 9.8e-14 51.2 1.0 1.8e-13 50.3 0.7 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_4 PF13535.1 AIC14879.1 - 7.2e-07 29.1 0.0 2.1e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp PF02222.17 AIC14879.1 - 5.2e-05 22.6 0.0 9.8e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 AIC14879.1 - 0.00021 20.6 0.1 0.00045 19.5 0.0 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Transp_cyt_pur PF02133.10 AIC14880.1 - 1.2e-30 106.4 33.9 1.9e-30 105.8 23.5 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin CcmD PF04995.9 AIC14880.1 - 0.067 12.9 0.3 0.067 12.9 0.2 3.9 3 0 0 3 3 3 0 Heme exporter protein D (CcmD) ThiC PF01964.13 AIC14881.1 - 7.8e-177 588.0 0.1 8.9e-177 587.8 0.1 1.0 1 0 0 1 1 1 1 ThiC family Phos_pyr_kin PF08543.7 AIC14884.1 - 1.1e-83 280.2 2.0 1.5e-83 279.7 1.4 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase Aldolase_2 PF10120.4 AIC14884.1 - 2.6e-56 189.6 0.6 1.5e-55 187.1 0.2 2.1 2 0 0 2 2 2 1 Putative aldolase PfkB PF00294.19 AIC14884.1 - 3.6e-14 52.6 0.2 6.6e-14 51.7 0.2 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase NTP_transferase PF00483.18 AIC14885.1 - 5.5e-35 120.8 0.0 6.2e-35 120.6 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.2 AIC14885.1 - 1e-11 45.1 0.0 1.4e-11 44.7 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.14 AIC14885.1 - 8.2e-05 22.3 0.0 0.00016 21.4 0.0 1.5 1 1 0 1 1 1 1 Cytidylyltransferase IspD PF01128.14 AIC14885.1 - 0.0011 18.5 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_4 PF13562.1 AIC14886.1 - 5.1e-15 55.4 0.0 7.6e-15 54.8 0.0 1.3 1 0 0 1 1 1 1 Sugar nucleotidyl transferase Hexapep PF00132.19 AIC14886.1 - 3e-05 23.3 2.6 5.3 6.7 0.0 5.3 3 1 1 5 5 5 2 Bacterial transferase hexapeptide (six repeats) Phage_integrase PF00589.17 AIC14887.1 - 3.3e-05 23.6 0.1 0.00051 19.7 0.1 2.4 1 1 0 1 1 1 1 Phage integrase family HTH_38 PF13936.1 AIC14887.1 - 4.9e-05 22.7 1.5 8.6e-05 22.0 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.1 AIC14887.1 - 0.03 13.7 0.0 0.067 12.5 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_Crp_2 PF13545.1 AIC14889.1 - 0.00091 18.9 0.0 0.0017 18.1 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain FUR PF01475.14 AIC14889.1 - 0.0045 16.9 0.0 0.0056 16.6 0.0 1.3 1 0 0 1 1 1 1 Ferric uptake regulator family LacI PF00356.16 AIC14889.1 - 0.015 14.9 0.1 0.042 13.4 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family HTH_23 PF13384.1 AIC14889.1 - 0.018 14.6 0.0 0.052 13.2 0.0 1.8 2 0 0 2 2 2 0 Homeodomain-like domain HTH_24 PF13412.1 AIC14889.1 - 0.024 14.0 0.0 0.049 13.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC14889.1 - 0.073 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 MarR family Ubiq_cyt_C_chap PF03981.7 AIC14889.1 - 0.077 12.8 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone HTH_29 PF13551.1 AIC14889.1 - 0.12 12.5 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Opacity PF02462.10 AIC14889.1 - 0.12 12.2 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Opacity family porin protein Ins_allergen_rp PF06757.8 AIC14890.1 - 0.035 13.5 0.0 0.24 10.8 0.0 1.8 1 1 0 2 2 2 0 Insect allergen related repeat, nitrile-specifier detoxification McrBC PF10117.4 AIC14891.1 - 4.9e-05 22.4 0.0 0.00011 21.2 0.0 1.5 1 1 0 1 1 1 1 McrBC 5-methylcytosine restriction system component DUF524 PF04411.7 AIC14891.1 - 0.0017 18.2 1.5 0.086 12.6 1.0 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF524) AAA_5 PF07728.9 AIC14892.1 - 1.1e-16 60.8 0.0 2.2e-16 59.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.1 AIC14892.1 - 0.00075 19.6 0.0 0.0092 16.1 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.1 AIC14892.1 - 0.0011 18.6 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 AIC14892.1 - 0.0052 16.7 0.0 0.067 13.1 0.0 2.6 3 0 0 3 3 3 1 AAA ATPase domain Mg_chelatase PF01078.16 AIC14892.1 - 0.0057 15.8 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.6 AIC14892.1 - 0.08 12.5 0.0 4.6 6.8 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 AIC14892.1 - 0.081 13.1 0.1 0.52 10.5 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.7 AIC14892.1 - 0.13 11.3 0.0 0.28 10.1 0.0 1.5 1 0 0 1 1 1 0 Holliday junction DNA helicase ruvB N-terminus TIP49 PF06068.8 AIC14892.1 - 0.13 10.9 0.0 0.23 10.1 0.0 1.3 1 0 0 1 1 1 0 TIP49 C-terminus AAA_30 PF13604.1 AIC14892.1 - 0.16 11.5 0.0 0.29 10.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.1 AIC14892.1 - 0.35 11.7 2.6 3.7 8.3 0.0 3.8 4 1 1 5 5 5 0 AAA domain SIMPL PF04402.9 AIC14893.1 - 4.7e-28 98.4 7.8 2.1e-17 63.6 0.5 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF541) Imm7 PF15588.1 AIC14893.1 - 0.0079 16.2 0.1 0.015 15.3 0.0 1.4 1 0 0 1 1 1 1 Immunity protein 7 DUF4265 PF14085.1 AIC14893.1 - 0.11 12.2 0.0 4.8 6.9 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4265) Peptidase_S49 PF01343.13 AIC14894.1 - 0.12 12.1 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Peptidase family S49 Epimerase_2 PF02350.14 AIC14895.1 - 4e-52 177.1 0.0 5.1e-52 176.7 0.0 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase GshA PF08886.6 AIC14896.1 - 0.083 11.1 0.0 0.1 10.8 0.0 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase SLAC1 PF03595.12 AIC14896.1 - 0.12 10.9 11.1 0.19 10.3 7.7 1.3 1 1 0 1 1 1 0 Voltage-dependent anion channel 7TMR-DISM_7TM PF07695.6 AIC14896.1 - 0.22 11.1 8.7 0.66 9.6 6.0 1.8 1 1 0 1 1 1 0 7TM diverse intracellular signalling FUSC PF04632.7 AIC14896.1 - 2.1 6.6 10.4 3.3 6.0 7.2 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4536 PF15055.1 AIC14896.1 - 3.5 7.7 9.3 0.18 11.9 1.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4536) GalP_UDP_transf PF01087.17 AIC14897.1 - 2.3e-12 47.3 0.0 8.5e-11 42.2 0.0 2.4 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain HIT PF01230.18 AIC14897.1 - 2.3e-09 37.6 0.0 0.00074 20.0 0.0 2.5 2 0 0 2 2 2 2 HIT domain GalP_UDP_tr_C PF02744.12 AIC14897.1 - 7.5e-05 22.3 0.0 0.00014 21.4 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DcpS_C PF11969.3 AIC14897.1 - 0.0006 20.0 0.0 0.0017 18.5 0.0 1.7 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding zf-Di19 PF05605.7 AIC14897.1 - 0.13 12.4 0.3 8.5 6.5 0.0 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-FPG_IleRS PF06827.9 AIC14898.1 - 0.00021 20.8 1.0 0.0005 19.6 0.1 1.8 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS TF_Zn_Ribbon PF08271.7 AIC14898.1 - 0.0081 15.4 3.2 0.096 12.0 2.2 2.1 1 1 0 1 1 1 1 TFIIB zinc-binding Gin PF10764.4 AIC14898.1 - 0.015 15.0 0.7 0.086 12.5 0.5 1.8 1 1 0 1 1 1 0 Inhibitor of sigma-G Gin DNA_RNApol_7kD PF03604.8 AIC14898.1 - 0.033 13.6 0.8 1.8 8.1 0.0 2.1 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Zn_Tnp_IS1595 PF12760.2 AIC14898.1 - 0.051 13.3 0.3 0.067 13.0 0.2 1.2 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-C4_ClpX PF06689.8 AIC14898.1 - 0.065 12.7 0.1 3.8 7.0 0.0 2.1 2 0 0 2 2 2 0 ClpX C4-type zinc finger FYVE PF01363.16 AIC14898.1 - 0.09 12.6 1.1 0.19 11.6 0.7 1.5 1 1 0 1 1 1 0 FYVE zinc finger zf-ribbon_3 PF13248.1 AIC14898.1 - 0.1 11.8 0.3 1 8.6 0.0 2.0 2 0 0 2 2 2 0 zinc-ribbon domain DUF4182 PF13790.1 AIC14898.1 - 0.12 12.2 0.1 8.4 6.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4182) Lar_restr_allev PF14354.1 AIC14898.1 - 0.14 12.5 0.2 0.15 12.3 0.1 1.1 1 0 0 1 1 1 0 Restriction alleviation protein Lar A2L_zn_ribbon PF08792.5 AIC14898.1 - 0.17 11.3 0.7 13 5.3 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-AD PF07776.10 AIC14898.1 - 0.21 11.6 0.9 5.2 7.1 0.1 2.0 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) DUF2688 PF10892.3 AIC14898.1 - 0.52 10.0 2.1 3.3 7.4 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2688) Prim_Zn_Ribbon PF08273.7 AIC14898.1 - 2.5 8.2 4.6 27 4.9 3.2 2.0 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase Glyco_tranf_2_2 PF10111.4 AIC14899.1 - 0.035 13.1 0.1 0.046 12.7 0.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase like family 2 PhosphMutase PF10143.4 AIC14900.1 - 5.8e-45 153.0 0.1 8.5e-45 152.4 0.0 1.3 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.13 AIC14900.1 - 3.5e-26 92.1 0.0 5.1e-26 91.5 0.0 1.3 1 1 0 1 1 1 1 Metalloenzyme superfamily Phosphodiest PF01663.17 AIC14900.1 - 0.016 14.5 0.0 0.1 11.9 0.0 2.1 2 0 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF2142 PF09913.4 AIC14901.1 - 0.018 13.7 0.1 0.018 13.7 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) PMP22_Claudin PF00822.15 AIC14901.1 - 0.036 13.7 0.0 0.038 13.6 0.0 1.0 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family TPT PF03151.11 AIC14901.1 - 0.045 13.3 0.3 0.049 13.2 0.2 1.1 1 0 0 1 1 1 0 Triose-phosphate Transporter family DUF4199 PF13858.1 AIC14901.1 - 0.051 13.4 0.0 0.056 13.3 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) P12 PF12669.2 AIC14901.1 - 0.077 13.2 0.7 2.2 8.5 0.1 2.0 2 0 0 2 2 2 0 Virus attachment protein p12 family DUF1469 PF07332.6 AIC14901.1 - 0.084 12.6 0.0 0.084 12.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) DUF4401 PF14351.1 AIC14901.1 - 0.1 11.5 0.2 0.11 11.5 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4401) Gram_pos_anchor PF00746.16 AIC14901.1 - 0.17 11.7 0.1 0.17 11.7 0.0 2.0 2 0 0 2 2 2 0 Gram positive anchor DUF202 PF02656.10 AIC14901.1 - 0.69 10.1 2.8 1.3 9.3 1.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DZR PF12773.2 AIC14902.1 - 0.0065 16.2 1.2 0.0096 15.7 0.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon NOB1_Zn_bind PF08772.6 AIC14902.1 - 0.028 14.2 0.1 0.034 13.9 0.1 1.2 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like A2L_zn_ribbon PF08792.5 AIC14902.1 - 0.053 12.9 2.2 4.3 6.9 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain DUF4379 PF14311.1 AIC14902.1 - 0.075 12.8 2.7 0.11 12.3 1.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4379) zf-ribbon_3 PF13248.1 AIC14902.1 - 0.64 9.2 4.8 4.2 6.7 0.9 2.2 1 1 1 2 2 2 0 zinc-ribbon domain HNH PF01844.18 AIC14902.1 - 0.66 9.8 4.3 0.94 9.4 0.8 2.0 2 0 0 2 2 2 0 HNH endonuclease RNA_POL_M_15KD PF02150.11 AIC14902.1 - 4.3 7.1 8.6 69 3.2 6.0 2.1 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit zf-B_box PF00643.19 AIC14902.1 - 5.8 6.8 7.9 19 5.2 5.5 1.8 1 1 0 1 1 1 0 B-box zinc finger TFIIB PF00382.14 AIC14903.1 - 1.4e-26 92.0 4.2 9.9e-14 50.9 1.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 AIC14903.1 - 3e-09 36.0 0.8 3e-09 36.0 0.6 1.7 2 0 0 2 2 2 1 TFIIB zinc-binding zf-C4_Topoisom PF01396.14 AIC14903.1 - 0.0054 16.2 2.0 0.021 14.3 0.5 2.3 2 1 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger zf-ribbon_3 PF13248.1 AIC14903.1 - 0.073 12.3 0.9 0.17 11.1 0.6 1.7 1 0 0 1 1 1 0 zinc-ribbon domain Cyclin_N PF00134.18 AIC14903.1 - 0.25 10.9 3.5 0.48 9.9 1.3 2.1 1 1 2 3 3 3 0 Cyclin, N-terminal domain OrfB_Zn_ribbon PF07282.6 AIC14903.1 - 0.44 10.2 5.2 0.13 11.9 1.3 1.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain UPF0547 PF10571.4 AIC14903.1 - 2.4 7.9 8.1 0.76 9.5 1.9 2.6 2 1 0 2 2 2 0 Uncharacterised protein family UPF0547 Spt4 PF06093.8 AIC14903.1 - 4.7 7.1 6.5 15 5.5 0.4 2.7 2 1 0 2 2 2 0 Spt4/RpoE2 zinc finger Gar1 PF04410.9 AIC14904.1 - 7.1e-07 28.7 0.0 1e-06 28.3 0.0 1.3 1 1 0 1 1 1 1 Gar1/Naf1 RNA binding region SRP19 PF01922.12 AIC14905.1 - 2.6e-17 63.1 0.1 3e-17 62.9 0.1 1.1 1 0 0 1 1 1 1 SRP19 protein AAA_33 PF13671.1 AIC14905.1 - 0.08 12.8 0.1 0.092 12.6 0.1 1.1 1 0 0 1 1 1 0 AAA domain Ribosomal_S8e PF01201.17 AIC14906.1 - 2.5e-29 102.0 4.3 2.7e-29 101.9 3.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e DUF387 PF04079.11 AIC14907.1 - 9.4e-37 125.8 0.8 1.1e-36 125.5 0.6 1.0 1 0 0 1 1 1 1 Putative transcriptional regulators (Ypuh-like) HTH_20 PF12840.2 AIC14907.1 - 0.0012 18.6 0.2 0.056 13.2 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.14 AIC14907.1 - 0.0014 18.3 1.6 0.028 14.1 0.1 2.5 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_15 PF12324.3 AIC14907.1 - 0.0051 16.4 0.3 0.15 11.7 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain of alkylmercury lyase PadR PF03551.9 AIC14907.1 - 0.078 12.7 0.3 0.62 9.8 0.1 2.2 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family ScpA_ScpB PF02616.9 AIC14908.1 - 1.5e-18 67.2 1.3 6.8e-09 35.6 0.1 2.1 1 1 1 2 2 2 2 ScpA/B protein DUF2207 PF09972.4 AIC14908.1 - 0.0032 16.1 0.0 0.0039 15.8 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) SNase PF00565.12 AIC14909.1 - 1.3e-07 31.7 0.0 1.5e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Staphylococcal nuclease homologue TPR_3 PF07720.7 AIC14910.1 - 0.012 15.4 0.4 0.2 11.5 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.13 AIC14910.1 - 0.038 13.8 0.3 1 9.3 0.0 2.5 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain HypD PF01924.11 AIC14910.1 - 0.042 12.5 0.1 0.057 12.1 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase formation hypA family Pyridox_oxidase PF01243.15 AIC14912.1 - 9.3e-15 54.4 0.0 1.3e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 AIC14912.1 - 1e-05 25.4 0.0 1.2e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Methyltransf_31 PF13847.1 AIC14913.1 - 8.4e-21 74.1 0.0 1.5e-20 73.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14913.1 - 1.7e-15 57.5 0.0 3.4e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC14913.1 - 2.6e-13 49.9 0.0 4.2e-13 49.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14913.1 - 3.3e-13 49.9 0.0 6.1e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC14913.1 - 9e-11 42.1 0.0 1.6e-10 41.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 AIC14913.1 - 1.4e-08 33.9 0.0 2.6e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 AIC14913.1 - 1.5e-08 34.1 0.0 2.7e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 AIC14913.1 - 7.4e-08 32.6 0.0 1.7e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC14913.1 - 2.8e-06 27.3 0.0 9.7e-06 25.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC14913.1 - 1.5e-05 24.2 0.0 2.6e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GCD14 PF08704.5 AIC14913.1 - 6.3e-05 22.5 0.0 9.9e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PrmA PF06325.8 AIC14913.1 - 0.00015 21.0 0.0 0.00034 19.8 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 AIC14913.1 - 0.0005 19.2 0.0 0.00077 18.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PCMT PF01135.14 AIC14913.1 - 0.0011 18.5 0.0 0.0017 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FmrO PF07091.6 AIC14913.1 - 0.0068 15.4 0.0 0.01 14.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) TehB PF03848.9 AIC14913.1 - 0.015 14.4 0.0 0.034 13.2 0.0 1.6 2 0 0 2 2 2 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.1 AIC14913.1 - 0.038 13.6 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.1 AIC14913.1 - 0.075 13.8 0.0 0.28 12.0 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_2 PF00891.13 AIC14913.1 - 0.084 12.0 0.0 0.18 10.9 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase Dimerisation PF08100.6 AIC14913.1 - 0.12 12.2 0.0 0.29 10.9 0.0 1.7 1 0 0 1 1 1 0 Dimerisation domain GidB PF02527.10 AIC14913.1 - 0.18 10.9 0.0 0.3 10.2 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Oxidored_q6 PF01058.17 AIC14914.1 - 1.2e-30 105.7 1.1 2.5e-30 104.7 0.2 1.8 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Fer4_7 PF12838.2 AIC14914.1 - 0.00024 21.4 0.6 0.0025 18.1 0.2 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_15 PF13459.1 AIC14914.1 - 0.00054 20.4 4.7 0.00085 19.8 0.1 3.1 3 1 0 3 3 3 1 4Fe-4S single cluster domain Fer4_13 PF13370.1 AIC14914.1 - 0.0028 18.0 0.1 0.0028 18.0 0.1 2.6 3 0 0 3 3 3 1 4Fe-4S single cluster domain Fer4_10 PF13237.1 AIC14914.1 - 0.01 15.6 0.9 0.057 13.2 0.7 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4 PF00037.22 AIC14914.1 - 0.024 14.2 5.5 0.069 12.7 0.4 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.1 AIC14914.1 - 0.034 14.1 1.0 0.099 12.6 0.7 1.7 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_2 PF12797.2 AIC14914.1 - 0.047 13.6 3.9 1 9.3 0.4 2.7 2 0 0 2 2 2 0 4Fe-4S binding domain Complex1_49kDa PF00346.14 AIC14915.1 - 1.2e-21 76.9 0.8 2.5e-18 66.0 0.6 2.9 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Complex1_30kDa PF00329.14 AIC14915.1 - 9.1e-21 74.0 0.0 2e-20 72.9 0.0 1.6 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Oxidored_q1 PF00361.15 AIC14916.1 - 2.5e-56 190.9 19.3 2.5e-56 190.9 13.3 1.8 2 0 0 2 2 2 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q1_N PF00662.15 AIC14916.1 - 0.02 14.4 3.8 0.09 12.3 0.0 3.2 3 0 0 3 3 3 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidored_q2 PF00420.19 AIC14917.1 - 0.00031 20.2 9.2 0.00031 20.2 6.4 2.7 1 1 1 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L WSS_VP PF12175.3 AIC14917.1 - 0.025 13.6 0.5 0.025 13.6 0.3 1.7 2 0 0 2 2 2 0 White spot syndrome virus structural envelope protein VP NADHdh PF00146.16 AIC14918.1 - 1.6e-20 73.4 13.3 2.1e-20 73.0 9.2 1.0 1 0 0 1 1 1 1 NADH dehydrogenase Oxidored_q1 PF00361.15 AIC14919.1 - 5.6e-55 186.4 15.2 3e-54 184.1 10.5 2.3 1 0 0 1 1 1 1 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q1_N PF00662.15 AIC14919.1 - 0.1 12.1 0.1 0.1 12.1 0.1 3.1 2 1 1 3 3 3 0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus DUF3481 PF11980.3 AIC14919.1 - 2.3 8.1 4.2 8.9 6.2 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3481) TrmB PF01978.14 AIC14920.1 - 0.0019 17.8 0.0 0.0046 16.6 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB RNA_pol_Rpc34 PF05158.7 AIC14920.1 - 0.037 13.2 0.0 0.056 12.6 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit B-block_TFIIIC PF04182.7 AIC14920.1 - 0.049 13.4 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC NAM PF02365.10 AIC14920.1 - 0.056 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 No apical meristem (NAM) protein eIF3g PF12353.3 AIC14920.1 - 0.091 12.6 0.8 0.21 11.5 0.5 1.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G Pyridox_oxidase PF01243.15 AIC14922.1 - 2.7e-12 46.5 0.0 4.3e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 AIC14922.1 - 7.4e-12 45.2 0.0 8.6e-12 45.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase ABC2_membrane PF01061.19 AIC14923.1 - 1.5e-30 105.9 17.9 1.5e-30 105.9 12.4 1.3 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 AIC14923.1 - 1.1e-16 60.8 16.6 1.1e-16 60.8 11.5 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC_tran PF00005.22 AIC14924.1 - 3.7e-26 92.0 0.0 9.8e-26 90.6 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 AIC14924.1 - 5.7e-15 56.0 0.2 3.3e-09 37.1 0.0 2.3 1 1 0 2 2 2 2 AAA domain AAA_29 PF13555.1 AIC14924.1 - 5.4e-05 22.6 0.1 0.00012 21.5 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain DUF4162 PF13732.1 AIC14924.1 - 0.00018 21.9 0.0 0.00043 20.7 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_19 PF13245.1 AIC14924.1 - 0.0021 17.7 0.1 0.063 13.0 0.1 2.6 2 0 0 2 2 2 1 Part of AAA domain SRP54 PF00448.17 AIC14924.1 - 0.0046 16.4 0.1 0.0076 15.7 0.1 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_23 PF13476.1 AIC14924.1 - 0.0088 16.3 0.0 0.014 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 AIC14924.1 - 0.0092 16.1 0.0 0.061 13.5 0.0 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 AIC14924.1 - 0.0096 14.6 0.0 0.013 14.2 0.0 1.1 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_16 PF13191.1 AIC14924.1 - 0.024 14.6 0.3 0.059 13.3 0.2 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.1 AIC14924.1 - 0.032 14.3 0.3 0.17 12.0 0.2 2.2 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 AIC14924.1 - 0.037 13.6 0.3 0.23 10.9 0.1 2.3 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.1 AIC14924.1 - 0.059 12.7 1.0 1.2 8.4 0.1 2.7 3 0 0 3 3 3 0 AAA domain UPF0079 PF02367.12 AIC14924.1 - 0.067 12.8 1.7 0.18 11.4 0.1 2.3 3 0 0 3 3 3 0 Uncharacterised P-loop hydrolase UPF0079 SMC_N PF02463.14 AIC14924.1 - 0.086 12.0 0.0 1.2 8.2 0.0 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.1 AIC14924.1 - 0.097 12.2 0.9 0.3 10.6 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_15 PF13175.1 AIC14924.1 - 0.11 11.5 0.0 4.8 6.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Abhydrolase_6 PF12697.2 AIC14925.1 - 1.6e-28 100.1 0.0 2e-28 99.8 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AIC14925.1 - 9e-11 41.7 0.0 2.1e-09 37.3 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AIC14925.1 - 1.1e-08 34.8 0.0 1.7e-08 34.3 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.15 AIC14925.1 - 0.0042 16.5 0.0 0.0063 15.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.9 AIC14925.1 - 0.021 13.3 0.0 0.038 12.4 0.0 1.4 1 0 0 1 1 1 0 Ndr family Methyltransf_21 PF05050.7 AIC14926.1 - 6.1e-29 101.1 0.0 7.9e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase FkbM domain Methyltransf_18 PF12847.2 AIC14926.1 - 1.3e-08 35.4 0.0 2.9e-08 34.2 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.11 AIC14926.1 - 1.2e-07 31.5 0.0 1.7e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.1 AIC14926.1 - 2.8e-06 27.1 0.0 9.4e-05 22.1 0.0 2.4 1 1 1 2 2 2 1 Methyltransferase domain V_cholerae_RfbT PF05575.6 AIC14926.1 - 0.00038 19.6 0.0 0.00071 18.7 0.0 1.4 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein RrnaAD PF00398.15 AIC14926.1 - 0.0011 17.9 0.0 0.0016 17.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase tRNA_U5-meth_tr PF05958.6 AIC14926.1 - 0.0019 16.9 0.0 0.0025 16.5 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.1 AIC14926.1 - 0.0025 17.4 0.0 0.015 14.8 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC14926.1 - 0.0028 17.0 0.0 0.0045 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_26 PF13659.1 AIC14926.1 - 0.003 17.5 0.0 0.0045 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14926.1 - 0.01 16.3 0.0 0.033 14.6 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain FtsJ PF01728.14 AIC14926.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase HTH_24 PF13412.1 AIC14928.1 - 1.1e-06 27.8 2.9 1.9e-06 27.1 0.6 2.3 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC14928.1 - 8.5e-05 22.0 1.4 8.5e-05 22.0 1.0 2.6 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HTH_IclR PF09339.5 AIC14928.1 - 0.055 13.0 2.7 0.2 11.3 0.4 2.7 3 0 0 3 3 3 0 IclR helix-turn-helix domain MarR_2 PF12802.2 AIC14928.1 - 0.074 12.7 2.2 1.1 8.9 0.3 3.1 3 0 0 3 3 3 0 MarR family HTH_23 PF13384.1 AIC14928.1 - 0.27 10.9 0.1 0.27 10.9 0.1 2.6 4 0 0 4 4 4 0 Homeodomain-like domain Rieske PF00355.21 AIC14929.1 - 0.022 14.3 0.1 0.023 14.2 0.1 1.2 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain Herpes_Helicase PF02689.9 AIC14931.1 - 0.029 12.1 0.2 0.033 11.9 0.1 1.0 1 0 0 1 1 1 0 Helicase RHH_1 PF01402.16 AIC14932.1 - 0.0066 16.2 0.3 0.079 12.8 0.0 2.4 2 0 0 2 2 2 1 Ribbon-helix-helix protein, copG family HicB PF05534.7 AIC14932.1 - 0.014 14.9 0.1 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 HicB family Arc PF03869.9 AIC14932.1 - 0.043 13.4 0.0 0.098 12.2 0.0 1.5 1 0 0 1 1 1 0 Arc-like DNA binding domain SBP_bac_3 PF00497.15 AIC14933.1 - 2.4e-56 190.5 0.5 2.7e-56 190.3 0.4 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 LysR_substrate PF03466.15 AIC14933.1 - 0.062 12.3 0.0 1.9 7.5 0.0 3.0 2 1 0 2 2 2 0 LysR substrate binding domain CD20 PF04103.10 AIC14934.1 - 0.014 15.3 0.1 0.032 14.1 0.0 1.7 1 1 0 1 1 1 0 CD20-like family Tetraspannin PF00335.15 AIC14934.1 - 0.018 14.3 2.7 0.024 13.9 1.9 1.1 1 0 0 1 1 1 0 Tetraspanin family Herpes_LMP1 PF05297.6 AIC14934.1 - 2.9 6.7 16.2 3.8 6.3 11.2 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Daxx PF03344.10 AIC14934.1 - 6.4 5.1 12.4 8.1 4.7 8.6 1.1 1 0 0 1 1 1 0 Daxx Family TRAP_alpha PF03896.11 AIC14934.1 - 8.1 5.3 12.4 0.17 10.8 3.3 1.8 1 1 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit VID27 PF08553.5 AIC14934.1 - 8.1 4.5 14.0 9.5 4.2 9.7 1.0 1 0 0 1 1 1 0 VID27 cytoplasmic protein CD20 PF04103.10 AIC14935.1 - 0.09 12.7 0.6 0.42 10.5 0.4 2.2 1 1 0 1 1 1 0 CD20-like family bPH_3 PF14470.1 AIC14939.1 - 1.8e-05 24.9 0.0 2.1e-05 24.7 0.0 1.1 1 0 0 1 1 1 1 Bacterial PH domain bPH_1 PF08000.6 AIC14939.1 - 0.01 15.4 0.3 0.013 15.1 0.2 1.3 1 1 0 1 1 1 0 Bacterial PH domain TIG PF01833.19 AIC14940.1 - 1.9e-08 34.1 16.5 0.00024 21.0 0.6 4.6 3 3 1 4 4 4 3 IPT/TIG domain Qn_am_d_aIII PF09099.5 AIC14940.1 - 1e-05 25.7 3.8 0.46 10.8 0.3 3.7 3 1 0 3 3 3 2 Quinohemoprotein amine dehydrogenase, alpha subunit domain III A2M_N PF01835.14 AIC14940.1 - 2.9e-05 24.2 4.1 0.068 13.4 0.0 3.9 3 1 1 4 4 4 2 MG2 domain T2SI PF02501.12 AIC14940.1 - 0.005 16.7 0.8 0.022 14.7 0.2 2.2 2 0 0 2 2 2 1 Type II secretion system (T2SS), protein I BiPBP_C PF06832.7 AIC14940.1 - 0.0062 16.4 0.4 7.9 6.4 0.0 3.3 2 2 0 2 2 2 2 Penicillin-Binding Protein C-terminus Family Alph_Pro_TM PF09608.5 AIC14940.1 - 0.011 15.2 0.1 1.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Putative transmembrane protein (Alph_Pro_TM) DUF4625 PF15418.1 AIC14940.1 - 0.033 14.3 0.0 0.53 10.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) DUF4140 PF13600.1 AIC14940.1 - 0.24 11.8 3.8 10 6.6 0.1 3.0 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF4398 PF14346.1 AIC14941.1 - 2.5e-06 27.4 10.5 0.0012 18.8 5.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF4398) Cupredoxin_1 PF13473.1 AIC14941.1 - 3.9e-06 26.7 0.0 1.1e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 Cupredoxin-like domain MarR_2 PF12802.2 AIC14941.1 - 2.9e-05 23.6 0.1 0.0001 21.9 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_IclR PF09339.5 AIC14941.1 - 0.0049 16.4 0.0 0.014 14.9 0.0 1.8 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.1 AIC14941.1 - 0.035 13.4 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding NnrS PF05940.7 AIC14946.1 - 4.9 5.9 47.0 43 2.8 32.6 2.2 1 1 0 1 1 1 0 NnrS protein zf-C2H2_4 PF13894.1 AIC14947.1 - 0.0037 17.4 1.8 0.0057 16.8 0.8 1.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC14947.1 - 0.014 15.7 0.8 0.024 14.9 0.5 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-RanBP PF00641.13 AIC14947.1 - 0.014 14.4 0.8 0.027 13.5 0.5 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DUF629 PF04780.7 AIC14947.1 - 0.03 12.8 0.5 0.026 13.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF629) DUF2852 PF11014.3 AIC14947.1 - 0.069 13.1 0.3 0.076 12.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Abhydrolase_1 PF00561.15 AIC14948.1 - 4.2e-08 33.0 0.2 5e-08 32.7 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.2 AIC14948.1 - 7.8e-06 25.9 0.3 9e-06 25.7 0.2 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_4 PF08386.5 AIC14948.1 - 0.00011 22.0 0.2 0.00013 21.8 0.1 1.1 1 0 0 1 1 1 1 TAP-like protein Abhydrolase_5 PF12695.2 AIC14948.1 - 0.00037 20.2 0.1 0.0005 19.8 0.1 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family FSH1 PF03959.8 AIC14948.1 - 0.0085 15.5 0.4 0.0098 15.3 0.2 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DUF2048 PF09752.4 AIC14948.1 - 0.12 11.1 0.0 0.14 11.0 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2048) Bmp PF02608.9 AIC14949.1 - 3.1e-60 203.5 1.9 3.8e-60 203.2 1.3 1.1 1 0 0 1 1 1 1 Basic membrane protein Peripla_BP_6 PF13458.1 AIC14949.1 - 3.3e-05 23.4 2.1 0.021 14.1 0.2 2.2 2 0 0 2 2 2 2 Periplasmic binding protein Peripla_BP_4 PF13407.1 AIC14949.1 - 0.00017 21.0 3.6 0.00042 19.7 2.5 1.8 1 1 0 1 1 1 1 Periplasmic binding protein domain Fe-ADH PF00465.14 AIC14949.1 - 0.0023 16.6 0.0 0.0037 15.9 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Peripla_BP_3 PF13377.1 AIC14949.1 - 0.058 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Periplasmic binding protein-like domain IncA PF04156.9 AIC14949.1 - 0.078 12.5 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 IncA protein HATPase_c PF02518.21 AIC14950.1 - 2.3e-26 91.6 0.2 4.3e-26 90.8 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 AIC14950.1 - 8.1e-11 41.7 1.2 1.7e-10 40.7 0.3 1.9 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.1 AIC14950.1 - 6.9e-05 22.5 0.1 0.00017 21.2 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.1 AIC14950.1 - 7.5e-05 22.3 0.4 0.00022 20.8 0.0 1.9 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.1 AIC14950.1 - 0.001 18.8 0.0 0.0023 17.6 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Response_reg PF00072.19 AIC14952.1 - 6.6e-23 80.8 0.2 7.7e-23 80.6 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain AICARFT_IMPCHas PF01808.13 AIC14952.1 - 0.094 11.7 0.0 0.13 11.3 0.0 1.2 1 1 0 1 1 1 0 AICARFT/IMPCHase bienzyme NT5C PF06941.7 AIC14955.1 - 6.9e-15 55.0 0.1 7.9e-15 54.8 0.1 1.0 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Hydrolase PF00702.21 AIC14955.1 - 0.0036 17.7 0.0 0.0065 16.8 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 AIC14955.1 - 0.025 14.7 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Pribosyltran PF00156.22 AIC14957.1 - 0.0073 16.0 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_7 PF13537.1 AIC14957.1 - 0.13 11.9 0.4 0.39 10.4 0.0 2.0 3 0 0 3 3 3 0 Glutamine amidotransferase domain Aconitase_C PF00694.14 AIC14958.1 - 2.1e-39 134.6 0.0 3.4e-39 133.9 0.0 1.3 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.8 AIC14958.1 - 0.0039 16.6 0.0 0.16 11.3 0.0 2.1 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase PF00330.15 AIC14959.1 - 1.2e-170 568.0 0.0 1.3e-170 567.8 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF521 PF04412.8 AIC14959.1 - 0.039 12.4 0.0 0.1 11.0 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF521) Proteasome PF00227.21 AIC14960.1 - 7.1e-53 178.7 1.4 8.3e-53 178.5 1.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Peptidase_M3 PF01432.15 AIC14961.1 - 4.8e-05 22.5 2.0 0.001 18.2 1.4 2.7 1 1 0 1 1 1 1 Peptidase family M3 Peptidase_M32 PF02074.10 AIC14961.1 - 0.00078 18.1 0.0 0.013 14.1 0.0 2.2 2 0 0 2 2 2 1 Carboxypeptidase Taq (M32) metallopeptidase zf-FCS PF06467.9 AIC14963.1 - 0.098 12.3 0.2 0.24 11.0 0.1 1.6 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif DUF4364 PF14277.1 AIC14964.1 - 0.0078 15.8 1.5 0.0093 15.5 1.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) ATP-synt_F6 PF05511.6 AIC14964.1 - 0.0085 15.9 0.7 0.01 15.7 0.5 1.2 1 0 0 1 1 1 1 Mitochondrial ATP synthase coupling factor 6 DNA_ligase_A_C PF04679.10 AIC14964.1 - 0.01 16.2 0.2 0.012 15.9 0.1 1.2 1 0 0 1 1 1 0 ATP dependent DNA ligase C terminal region Zeta_toxin PF06414.7 AIC14964.1 - 0.012 14.7 0.1 0.014 14.5 0.1 1.2 1 0 0 1 1 1 0 Zeta toxin DUF573 PF04504.9 AIC14964.1 - 0.065 13.5 1.9 0.085 13.1 0.9 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF573 DUF4316 PF14195.1 AIC14964.1 - 0.079 13.0 1.2 0.1 12.6 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4316) Ground-like PF04155.13 AIC14964.1 - 0.12 12.7 3.3 1.1 9.5 0.6 2.0 1 1 1 2 2 2 0 Ground-like domain XkdN PF08890.6 AIC14964.1 - 0.19 11.4 4.0 0.23 11.2 2.8 1.1 1 0 0 1 1 1 0 Phage XkdN-like protein HTH_45 PF14947.1 AIC14966.1 - 0.0022 17.7 0.0 0.0076 16.0 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix TrmB PF01978.14 AIC14966.1 - 0.0024 17.5 0.0 0.0052 16.4 0.0 1.6 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.2 AIC14966.1 - 0.0044 16.7 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.2 AIC14966.1 - 0.0076 15.8 0.0 0.015 14.9 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.15 AIC14966.1 - 0.033 13.8 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_27 PF13463.1 AIC14966.1 - 0.086 13.1 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain Radical_SAM PF04055.16 AIC14967.1 - 1.8e-17 64.0 0.1 1.8e-17 64.0 0.0 2.8 3 0 0 3 3 3 1 Radical SAM superfamily Fer4_12 PF13353.1 AIC14967.1 - 3e-09 37.1 0.0 9.1e-09 35.5 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 AIC14967.1 - 2.4e-08 34.0 0.0 2.4e-08 34.0 0.0 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain TrmB PF01978.14 AIC14968.1 - 3.3e-20 71.5 0.0 9.7e-20 70.0 0.0 1.9 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 AIC14968.1 - 7.4e-09 34.9 0.0 9.9e-09 34.5 0.0 1.1 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_IclR PF09339.5 AIC14968.1 - 4.4e-05 22.9 0.0 0.00017 21.1 0.0 2.0 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.17 AIC14968.1 - 0.00038 20.0 0.0 0.0013 18.3 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.1 AIC14968.1 - 0.00067 19.9 0.0 0.0031 17.7 0.0 2.1 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_24 PF13412.1 AIC14968.1 - 0.00082 18.7 0.0 0.0019 17.5 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Penicillinase_R PF03965.11 AIC14968.1 - 0.018 15.1 0.0 0.054 13.5 0.0 1.9 2 0 0 2 2 2 0 Penicillinase repressor HTH_9 PF08221.6 AIC14968.1 - 0.02 14.7 0.0 0.053 13.3 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain PadR PF03551.9 AIC14968.1 - 0.041 13.6 0.0 0.1 12.4 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_36 PF13730.1 AIC14968.1 - 0.047 13.8 0.0 0.083 13.0 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Rrf2 PF02082.15 AIC14968.1 - 0.098 12.7 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator Fe_dep_repr_C PF02742.10 AIC14969.1 - 4.2e-20 71.1 0.3 6.9e-20 70.5 0.2 1.4 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain Fe_dep_repress PF01325.14 AIC14969.1 - 2.1e-14 53.2 0.4 4.1e-14 52.2 0.3 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_5 PF01022.15 AIC14969.1 - 2.9e-05 23.6 0.2 8e-05 22.2 0.0 1.8 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.2 AIC14969.1 - 8.6e-05 22.1 0.0 0.00015 21.3 0.0 1.4 1 0 0 1 1 1 1 MarR family Rrf2 PF02082.15 AIC14969.1 - 9.8e-05 22.3 0.1 0.00016 21.6 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator MarR PF01047.17 AIC14969.1 - 0.00052 19.6 0.0 0.00092 18.8 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_1 PF00126.22 AIC14969.1 - 0.00073 19.2 0.0 0.0017 18.0 0.0 1.6 1 1 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family HTH_45 PF14947.1 AIC14969.1 - 0.0015 18.2 0.2 0.0024 17.6 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_Crp_2 PF13545.1 AIC14969.1 - 0.003 17.3 0.0 0.0056 16.4 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TrmB PF01978.14 AIC14969.1 - 0.0044 16.6 0.1 0.0076 15.9 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.1 AIC14969.1 - 0.0057 16.9 0.0 0.009 16.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_37 PF13744.1 AIC14969.1 - 0.0093 15.7 0.0 0.02 14.6 0.0 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain AAA_assoc_C PF09821.4 AIC14969.1 - 0.013 15.8 0.1 0.024 14.8 0.0 1.5 1 1 0 1 1 1 0 C-terminal AAA-associated domain HTH_IclR PF09339.5 AIC14969.1 - 0.028 13.9 0.0 0.056 13.0 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain IF2_N PF04760.10 AIC14969.1 - 0.036 13.7 0.7 0.14 11.8 0.0 2.1 2 1 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region HTH_6 PF01418.12 AIC14969.1 - 0.042 13.5 0.0 0.081 12.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family HrcA_DNA-bdg PF03444.10 AIC14969.1 - 0.047 13.1 0.1 0.088 12.2 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_11 PF08279.7 AIC14969.1 - 0.047 13.3 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 HTH domain NLPC_P60 PF00877.14 AIC14969.1 - 0.06 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family HTH_20 PF12840.2 AIC14969.1 - 0.061 13.1 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain TFIIE_beta PF02186.10 AIC14969.1 - 0.13 12.2 0.3 0.32 11.0 0.1 1.7 2 0 0 2 2 2 0 TFIIE beta subunit core domain eRF1_1 PF03463.10 AIC14971.1 - 1.7e-21 76.1 0.1 3.2e-21 75.2 0.1 1.4 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.10 AIC14971.1 - 6.1e-12 45.7 0.2 2.4e-11 43.9 0.1 2.0 2 0 0 2 2 2 1 eRF1 domain 3 eRF1_2 PF03464.10 AIC14971.1 - 3.4e-08 33.8 0.0 7.1e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 2 CutA1 PF03091.10 AIC14972.1 - 8.1e-28 96.0 0.1 9.9e-28 95.7 0.1 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Ribosomal_L11 PF00298.14 AIC14972.1 - 0.0013 18.8 0.0 0.0031 17.5 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L11, RNA binding domain DUF354 PF04007.7 AIC14974.1 - 1.2e-45 155.8 0.0 1.4e-45 155.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF354) Glyco_trans_4_4 PF13579.1 AIC14974.1 - 0.00062 19.9 3.5 0.00065 19.8 0.2 2.4 2 1 0 2 2 2 1 Glycosyl transferase 4-like domain LpxB PF02684.10 AIC14974.1 - 0.0013 17.4 0.0 0.002 16.8 0.0 1.2 1 0 0 1 1 1 1 Lipid-A-disaccharide synthetase Glyco_tran_28_C PF04101.11 AIC14974.1 - 0.0023 17.5 0.0 0.0034 17.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Epimerase_2 PF02350.14 AIC14974.1 - 0.021 13.6 0.0 0.032 13.0 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase DUF2478 PF10649.4 AIC14974.1 - 0.077 12.3 0.1 0.23 10.8 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2478) Glycos_transf_1 PF00534.15 AIC14974.1 - 0.079 12.3 0.0 0.16 11.3 0.0 1.6 1 1 0 1 1 1 0 Glycosyl transferases group 1 Glyco_trans_1_3 PF13528.1 AIC14974.1 - 0.088 11.9 0.0 4.7 6.3 0.0 2.2 2 0 0 2 2 2 0 Glycosyl transferase family 1 2-Hacid_dh_C PF02826.14 AIC14975.1 - 1.7e-66 222.7 0.1 2.3e-66 222.3 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 AIC14975.1 - 6e-26 90.4 0.0 7.4e-26 90.1 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 AIC14975.1 - 1.7e-06 27.9 0.1 5e-06 26.4 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 AIC14975.1 - 5.5e-05 23.5 0.0 0.00018 21.8 0.0 2.0 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent IlvN PF07991.7 AIC14975.1 - 9.6e-05 21.8 0.2 0.00062 19.1 0.0 2.2 2 1 1 3 3 3 1 Acetohydroxy acid isomeroreductase, catalytic domain Shikimate_DH PF01488.15 AIC14975.1 - 0.004 17.2 0.1 0.008 16.2 0.1 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 AIC14975.1 - 0.0067 16.4 0.1 0.018 15.0 0.0 1.8 2 0 0 2 2 2 1 NADH(P)-binding adh_short PF00106.20 AIC14975.1 - 0.011 15.6 0.1 0.02 14.7 0.1 1.4 1 0 0 1 1 1 0 short chain dehydrogenase AdoHcyase_NAD PF00670.16 AIC14975.1 - 0.031 14.1 0.1 0.16 11.7 0.0 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 3HCDH_N PF02737.13 AIC14975.1 - 0.057 13.0 0.0 0.12 12.0 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Hexapep PF00132.19 AIC14976.1 - 9.9e-26 88.0 17.5 7.8e-09 34.6 2.4 3.4 2 1 0 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 AIC14976.1 - 1.1e-16 60.0 13.9 4e-09 35.8 1.9 4.1 3 1 1 4 4 4 4 Hexapeptide repeat of succinyl-transferase Trm112p PF03966.11 AIC14977.1 - 8.6e-09 35.6 0.3 1.9e-08 34.5 0.2 1.6 1 1 0 1 1 1 1 Trm112p-like protein GFO_IDH_MocA PF01408.17 AIC14978.1 - 6.3e-26 91.2 0.0 1.2e-25 90.3 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 AIC14978.1 - 7.5e-07 28.9 0.0 1.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain IlvN PF07991.7 AIC14978.1 - 0.00031 20.1 0.0 0.0018 17.6 0.0 2.0 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.10 AIC14978.1 - 0.0016 18.3 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ThiF PF00899.16 AIC14978.1 - 0.017 14.9 0.4 0.038 13.7 0.1 1.7 2 0 0 2 2 2 0 ThiF family 2-Hacid_dh_C PF02826.14 AIC14978.1 - 0.017 14.2 0.0 0.037 13.1 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 AIC14978.1 - 0.022 14.8 0.0 0.054 13.6 0.0 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase NAD_Gly3P_dh_N PF01210.18 AIC14978.1 - 0.029 14.0 0.0 0.059 13.0 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Aminotran_4 PF01063.14 AIC14979.1 - 8.9e-44 149.6 0.0 1.1e-43 149.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class IV DUF790 PF05626.6 AIC14980.1 - 0.062 11.8 0.0 0.13 10.7 0.0 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF790) Alba PF01918.16 AIC14981.1 - 7.5e-10 38.2 0.1 9.8e-10 37.8 0.1 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.3 AIC14981.1 - 0.064 12.8 1.0 0.9 9.1 0.1 2.2 1 1 1 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P HTH_AsnC-type PF13404.1 AIC14982.1 - 0.033 13.7 0.1 0.058 12.9 0.1 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain ADK PF00406.17 AIC14982.1 - 0.036 13.9 0.1 0.048 13.5 0.0 1.1 1 0 0 1 1 1 0 Adenylate kinase Mga PF05043.8 AIC14982.1 - 0.084 13.1 0.6 0.16 12.2 0.2 1.6 2 0 0 2 2 2 0 Mga helix-turn-helix domain ACT_4 PF13291.1 AIC14982.1 - 0.096 13.0 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 ACT domain GerE PF00196.14 AIC14983.1 - 0.00041 19.6 0.1 0.00096 18.4 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family HTH_23 PF13384.1 AIC14983.1 - 0.0012 18.4 0.0 0.0048 16.5 0.0 2.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_24 PF13412.1 AIC14983.1 - 0.0024 17.2 1.3 0.0047 16.2 0.9 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.16 AIC14983.1 - 0.0026 17.4 0.0 0.0048 16.5 0.0 1.4 1 0 0 1 1 1 1 AsnC family HTH_AsnC-type PF13404.1 AIC14983.1 - 0.014 14.9 1.2 0.056 13.0 0.8 1.9 1 1 0 1 1 1 0 AsnC-type helix-turn-helix domain DELLA PF12041.3 AIC14983.1 - 0.02 14.5 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal Sigma70_r4_2 PF08281.7 AIC14983.1 - 0.021 14.2 0.0 0.044 13.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 HTH_28 PF13518.1 AIC14983.1 - 0.026 14.5 0.0 0.061 13.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain FixG_C PF11614.3 AIC14984.1 - 0.041 13.9 0.8 2.5 8.2 0.0 2.7 2 1 1 3 3 3 0 IG-like fold at C-terminal of FixG, putative oxidoreductase He_PIG PF05345.7 AIC14984.1 - 0.096 12.7 1.2 0.32 11.0 0.5 2.2 1 1 0 1 1 1 0 Putative Ig domain DUF1180 PF06679.7 AIC14984.1 - 6 6.7 9.4 9.7 6.0 6.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) CcdA PF07362.7 AIC14985.1 - 0.56 10.1 2.4 6.6 6.6 0.2 2.7 3 0 0 3 3 3 0 Post-segregation antitoxin CcdA Methyltransf_31 PF13847.1 AIC14986.1 - 4.7e-17 61.9 0.0 7.6e-17 61.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC14986.1 - 2.9e-15 56.5 0.0 7.9e-15 55.1 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC14986.1 - 9.4e-11 41.9 0.0 2e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC14986.1 - 3.5e-10 40.2 0.0 9.8e-10 38.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC14986.1 - 8.5e-10 38.5 0.0 2.4e-09 37.1 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC14986.1 - 1.1e-09 38.8 0.0 2.8e-09 37.5 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC14986.1 - 9.7e-08 31.3 0.0 2.3e-07 30.1 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.12 AIC14986.1 - 0.0013 17.8 0.0 0.0028 16.7 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase MTS PF05175.9 AIC14986.1 - 0.0062 15.9 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DREV PF05219.7 AIC14986.1 - 0.013 14.4 0.0 0.019 13.8 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Trm112p PF03966.11 AIC14986.1 - 0.018 15.4 0.1 0.037 14.3 0.1 1.6 1 0 0 1 1 1 0 Trm112p-like protein Methyltransf_9 PF08003.6 AIC14986.1 - 0.04 12.6 0.0 0.056 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PCMT PF01135.14 AIC14986.1 - 0.13 11.7 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) META PF03724.11 AIC14987.1 - 1.4e-07 31.2 0.0 1.9e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 META domain AsnC_trans_reg PF01037.16 AIC14988.1 - 1.8e-12 46.7 0.2 2e-12 46.6 0.1 1.0 1 0 0 1 1 1 1 AsnC family SIS PF01380.17 AIC14989.1 - 3.9e-10 39.4 1.1 0.00022 20.8 0.8 3.0 2 1 0 2 2 2 2 SIS domain SIS_2 PF13580.1 AIC14989.1 - 0.022 14.4 5.8 0.034 13.8 0.4 3.2 2 2 2 4 4 4 0 SIS domain Rhodanese PF00581.15 AIC14990.1 - 1.4e-42 144.6 0.3 3.7e-20 72.3 0.1 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Fe_dep_repress PF01325.14 AIC14991.1 - 1.6e-21 75.9 2.0 1.8e-21 75.8 0.5 1.7 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain Fe_dep_repr_C PF02742.10 AIC14991.1 - 1.3e-13 50.4 1.3 3.3e-13 49.1 0.9 1.7 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain HTH_24 PF13412.1 AIC14991.1 - 3.4e-06 26.3 0.0 7.2e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC14991.1 - 7.8e-06 25.4 0.0 1.9e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 MarR family HTH_27 PF13463.1 AIC14991.1 - 1.9e-05 24.9 0.1 7.7e-05 22.9 0.0 2.0 2 1 1 3 3 3 1 Winged helix DNA-binding domain TrmB PF01978.14 AIC14991.1 - 4.3e-05 23.1 0.1 8.3e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_11 PF08279.7 AIC14991.1 - 6.2e-05 22.5 0.0 0.00014 21.4 0.0 1.6 1 0 0 1 1 1 1 HTH domain LexA_DNA_bind PF01726.11 AIC14991.1 - 0.00014 21.3 0.0 0.00051 19.5 0.0 1.8 2 0 0 2 2 2 1 LexA DNA binding domain FeoC PF09012.5 AIC14991.1 - 0.00047 19.8 0.0 0.001 18.7 0.0 1.6 1 0 0 1 1 1 1 FeoC like transcriptional regulator MarR PF01047.17 AIC14991.1 - 0.00057 19.5 0.0 0.0016 18.1 0.0 1.8 2 0 0 2 2 1 1 MarR family HTH_DeoR PF08220.7 AIC14991.1 - 0.0014 18.1 0.1 0.029 13.9 0.0 2.7 2 1 1 3 3 3 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.15 AIC14991.1 - 0.0016 18.5 0.1 0.0026 17.8 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator EAP30 PF04157.11 AIC14991.1 - 0.0061 15.7 0.3 0.009 15.1 0.0 1.4 2 0 0 2 2 2 1 EAP30/Vps36 family HTH_Crp_2 PF13545.1 AIC14991.1 - 0.01 15.6 0.0 0.031 14.0 0.0 1.8 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain TFIIE_alpha PF02002.12 AIC14991.1 - 0.01 15.3 0.1 0.02 14.3 0.0 1.6 2 0 0 2 2 1 0 TFIIE alpha subunit TALPID3 PF15324.1 AIC14991.1 - 0.012 13.0 0.1 0.013 12.9 0.0 1.0 1 0 0 1 1 1 0 Hedgehog signalling target DUF977 PF06163.6 AIC14991.1 - 0.036 13.8 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) DUF4423 PF14394.1 AIC14991.1 - 0.036 13.6 0.0 0.057 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) DUF2250 PF10007.4 AIC14991.1 - 0.04 13.8 0.1 0.07 13.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_1 PF00126.22 AIC14991.1 - 0.051 13.3 0.2 0.27 10.9 0.0 2.2 2 1 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family PAX PF00292.13 AIC14991.1 - 0.061 13.0 0.0 0.085 12.5 0.0 1.2 1 0 0 1 1 1 0 'Paired box' domain DUF2042 PF09743.4 AIC14991.1 - 0.061 12.6 0.0 0.08 12.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2042) HTH_37 PF13744.1 AIC14991.1 - 0.062 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Penicillinase_R PF03965.11 AIC14991.1 - 0.075 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Penicillinase repressor HTH_23 PF13384.1 AIC14991.1 - 0.081 12.5 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_34 PF13601.1 AIC14991.1 - 0.096 12.7 0.0 0.18 11.8 0.0 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain T2SE PF00437.15 AIC14992.1 - 3.6e-12 45.7 0.0 8.6e-12 44.5 0.0 1.7 1 1 0 1 1 1 1 Type II/IV secretion system protein KH_1 PF00013.24 AIC14992.1 - 8.2e-11 41.3 2.4 1.1e-10 40.9 0.1 2.5 3 0 0 3 3 1 1 KH domain KH_3 PF13014.1 AIC14992.1 - 3.7e-08 32.8 0.1 2.7e-07 30.0 0.0 2.6 2 0 0 2 2 2 1 KH domain AAA_17 PF13207.1 AIC14992.1 - 8.3e-06 26.6 0.0 3.8e-05 24.4 0.0 2.2 2 0 0 2 2 1 1 AAA domain PIN_4 PF13638.1 AIC14992.1 - 2.3e-05 24.5 0.1 0.00012 22.1 0.1 2.1 1 1 0 1 1 1 1 PIN domain ArgK PF03308.11 AIC14992.1 - 3e-05 22.9 0.0 5.8e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 ArgK protein AAA_18 PF13238.1 AIC14992.1 - 6.1e-05 23.3 0.0 0.00021 21.5 0.0 2.0 2 0 0 2 2 1 1 AAA domain KH_2 PF07650.12 AIC14992.1 - 7.4e-05 22.2 0.3 0.00036 20.0 0.2 2.2 1 0 0 1 1 1 1 KH domain AAA_16 PF13191.1 AIC14992.1 - 8.6e-05 22.5 0.0 0.00017 21.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.12 AIC14992.1 - 0.00031 20.2 0.0 0.00057 19.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_25 PF13481.1 AIC14992.1 - 0.00035 20.0 0.0 0.00085 18.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AIC14992.1 - 0.00041 20.2 0.0 0.0012 18.7 0.0 1.8 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 AIC14992.1 - 0.0015 18.8 0.0 0.004 17.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_5 PF07728.9 AIC14992.1 - 0.0025 17.5 0.0 0.0063 16.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 AIC14992.1 - 0.0027 17.3 0.0 0.0091 15.7 0.0 1.9 2 0 0 2 2 1 1 Part of AAA domain AAA_22 PF13401.1 AIC14992.1 - 0.0041 17.2 0.0 0.017 15.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 AIC14992.1 - 0.0048 16.7 0.0 0.022 14.6 0.0 2.1 2 0 0 2 2 1 1 AAA domain UPF0278 PF08745.6 AIC14992.1 - 0.007 15.6 0.0 0.043 13.0 0.0 2.3 2 0 0 2 2 2 1 UPF0278 family KH_4 PF13083.1 AIC14992.1 - 0.0077 15.8 0.2 0.055 13.1 0.0 2.5 2 0 0 2 2 2 1 KH domain NTPase_1 PF03266.10 AIC14992.1 - 0.0084 15.8 0.2 0.031 13.9 0.0 2.1 3 0 0 3 3 1 1 NTPase Zeta_toxin PF06414.7 AIC14992.1 - 0.0089 15.1 0.1 0.021 13.9 0.1 1.5 1 0 0 1 1 1 1 Zeta toxin AAA_10 PF12846.2 AIC14992.1 - 0.01 15.2 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain AAA_29 PF13555.1 AIC14992.1 - 0.013 14.9 0.0 0.047 13.2 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.1 AIC14992.1 - 0.017 14.7 0.0 0.047 13.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.5 AIC14992.1 - 0.017 14.3 0.0 0.034 13.3 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 MobB PF03205.9 AIC14992.1 - 0.018 14.7 0.0 0.05 13.3 0.0 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_28 PF13521.1 AIC14992.1 - 0.018 15.0 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.12 AIC14992.1 - 0.019 14.4 0.1 0.036 13.6 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA PF00004.24 AIC14992.1 - 0.02 15.1 0.1 0.082 13.1 0.0 2.1 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 AIC14992.1 - 0.04 13.0 0.1 0.1 11.7 0.0 1.6 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.11 AIC14992.1 - 0.044 13.0 0.0 0.1 11.7 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein PPV_E1_C PF00519.12 AIC14992.1 - 0.046 12.3 0.0 0.069 11.7 0.0 1.1 1 0 0 1 1 1 0 Papillomavirus helicase NACHT PF05729.7 AIC14992.1 - 0.061 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 AIC14992.1 - 0.067 13.3 0.0 0.17 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase DUF258 PF03193.11 AIC14992.1 - 0.083 12.0 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 NB-ARC PF00931.17 AIC14992.1 - 0.1 11.4 0.0 0.17 10.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain DAP3 PF10236.4 AIC14992.1 - 0.11 11.4 0.0 0.2 10.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 MMR_HSR1 PF01926.18 AIC14992.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sigma54_activ_2 PF14532.1 AIC14992.1 - 0.15 12.1 0.0 0.33 11.0 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain P-II PF00543.17 AIC14993.1 - 2.1e-28 98.7 0.0 2.4e-28 98.6 0.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II Peptidase_M10 PF00413.19 AIC14994.1 - 4.2e-05 23.3 0.1 5.9e-05 22.8 0.1 1.3 1 1 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.4 AIC14994.1 - 0.0015 17.4 0.3 0.0024 16.8 0.2 1.3 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_3 PF13582.1 AIC14994.1 - 0.011 16.2 0.1 0.02 15.4 0.1 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF3152 PF11350.3 AIC14994.1 - 0.019 14.4 0.1 0.043 13.3 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3152) BSP PF04450.7 AIC14994.1 - 0.13 11.7 0.3 0.2 11.1 0.0 1.4 2 0 0 2 2 2 0 Peptidase of plants and bacteria YfhO PF09586.5 AIC14994.1 - 0.15 10.0 0.3 0.2 9.6 0.2 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Metallopep PF12044.3 AIC14994.1 - 0.21 9.9 0.6 0.31 9.4 0.4 1.2 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M24 PF00557.19 AIC14995.1 - 1.2e-39 136.0 0.3 1.3e-39 135.9 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF917 PF06032.7 AIC14995.1 - 0.057 11.9 0.1 0.11 11.0 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF917) OrfB_Zn_ribbon PF07282.6 AIC14996.1 - 0.0044 16.6 5.4 0.021 14.4 3.8 1.8 1 1 0 1 1 1 1 Putative transposase DNA-binding domain Nudix_N_2 PF14803.1 AIC14996.1 - 0.0052 16.4 1.0 0.016 14.8 0.7 1.7 1 1 1 2 2 2 1 Nudix N-terminal TF_Zn_Ribbon PF08271.7 AIC14996.1 - 0.015 14.5 2.7 2.6 7.4 0.3 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding A2L_zn_ribbon PF08792.5 AIC14996.1 - 0.021 14.2 2.4 1.3 8.5 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-ribbon_3 PF13248.1 AIC14996.1 - 0.024 13.8 0.8 5.2 6.4 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 AIC14996.1 - 0.027 14.4 1.6 2.8 7.9 0.1 2.2 2 0 0 2 2 2 0 Zinc ribbon domain DZR PF12773.2 AIC14996.1 - 0.064 13.0 2.0 0.12 12.1 1.4 1.5 1 1 0 1 1 1 0 Double zinc ribbon YhfH PF14149.1 AIC14996.1 - 0.076 12.8 1.8 4.1 7.2 0.1 2.3 2 0 0 2 2 2 0 YhfH-like protein zf-IS66 PF13005.2 AIC14996.1 - 0.08 12.9 1.7 1.7 8.7 0.1 2.3 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 C1_1 PF00130.17 AIC14996.1 - 0.088 12.5 1.5 0.51 10.1 1.1 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-ISL3 PF14690.1 AIC14996.1 - 0.1 12.6 0.4 11 6.1 0.0 2.2 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc_ribbon_2 PF13240.1 AIC14996.1 - 0.13 11.7 3.5 6.8 6.3 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-C3HC4_3 PF13920.1 AIC14996.1 - 0.24 11.1 2.1 0.61 9.8 1.5 1.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_1 PF14446.1 AIC14996.1 - 0.29 10.9 3.2 1.4 8.7 2.2 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 zf-C2H2_3 PF13878.1 AIC14996.1 - 0.48 10.0 1.9 19 4.9 0.1 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO Zn_Tnp_IS1595 PF12760.2 AIC14996.1 - 0.48 10.2 3.0 3.9 7.3 2.1 2.0 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-DNL PF05180.7 AIC14996.1 - 0.5 10.1 3.8 2.7 7.7 0.1 2.1 1 1 1 2 2 2 0 DNL zinc finger Zn_ribbon_recom PF13408.1 AIC14996.1 - 1.5 9.1 5.1 29 5.0 3.5 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF1512 PF07431.7 AIC14997.1 - 3.2e-105 351.7 13.3 4e-105 351.4 9.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1512) EB PF01683.13 AIC14998.1 - 0.47 10.5 5.4 0.7 10.0 3.8 1.3 1 0 0 1 1 1 0 EB module Molydop_binding PF01568.16 AIC14999.1 - 0.01 15.6 0.0 0.036 13.8 0.0 1.8 1 1 0 1 1 1 0 Molydopterin dinucleotide binding domain DUF1090 PF06476.7 AIC15000.1 - 4.8e-05 23.0 11.2 4.8e-05 23.0 7.8 3.8 1 1 3 4 4 3 2 Protein of unknown function (DUF1090) Reo_sigmaC PF04582.7 AIC15000.1 - 0.029 13.5 3.1 0.92 8.6 0.5 2.3 1 1 0 2 2 2 0 Reovirus sigma C capsid protein KNOX2 PF03791.8 AIC15000.1 - 0.048 12.9 1.4 0.13 11.5 0.2 2.4 2 0 0 2 2 2 0 KNOX2 domain DUF869 PF05911.6 AIC15000.1 - 0.091 10.9 41.0 0.14 10.3 17.9 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF869) NPV_P10 PF05531.7 AIC15000.1 - 0.14 12.4 11.6 20 5.5 3.0 4.5 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.7 AIC15000.1 - 0.33 10.7 9.7 7.5 6.3 1.7 3.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Not1 PF04054.10 AIC15000.1 - 0.44 9.3 5.0 0.16 10.8 1.6 1.7 1 1 0 1 1 1 0 CCR4-Not complex component, Not1 COG2 PF06148.6 AIC15000.1 - 1.4 8.7 28.6 0.37 10.6 2.7 4.2 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 YqzH PF14164.1 AIC15000.1 - 1.7 8.5 5.9 0.38 10.6 0.2 2.9 2 2 1 3 3 3 0 YqzH-like protein Allexi_40kDa PF05549.6 AIC15000.1 - 2.3 7.4 24.3 0.59 9.3 2.6 3.1 1 1 2 3 3 3 0 Allexivirus 40kDa protein Laminin_II PF06009.7 AIC15000.1 - 3.5 7.3 26.4 1.2 8.8 4.5 3.3 1 1 3 4 4 4 0 Laminin Domain II ERM PF00769.14 AIC15000.1 - 3.5 7.0 56.3 0.27 10.7 5.4 3.1 1 1 2 3 3 3 0 Ezrin/radixin/moesin family UPF0184 PF03670.8 AIC15000.1 - 7.6 6.7 9.7 0.8 9.9 0.8 3.2 2 2 1 3 3 3 0 Uncharacterised protein family (UPF0184) Peptidase_C65 PF10275.4 AIC15001.1 - 0.012 14.9 0.0 0.017 14.4 0.0 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain APH PF01636.18 AIC15002.1 - 0.013 15.2 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.9 AIC15002.1 - 0.064 12.3 0.0 0.18 10.8 0.0 1.8 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Ubie_methyltran PF01209.13 AIC15003.1 - 2.9e-19 69.1 0.0 3.6e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 AIC15003.1 - 9.3e-19 67.7 0.0 2.1e-18 66.5 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15003.1 - 2.5e-12 47.0 0.0 4.9e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15003.1 - 1.9e-11 43.9 0.0 2.9e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15003.1 - 1.8e-10 40.6 0.0 2.7e-10 40.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15003.1 - 1.2e-09 38.7 0.0 2.5e-09 37.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC15003.1 - 2.2e-09 37.3 1.2 1.3e-08 34.8 0.6 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15003.1 - 9.4e-08 32.4 0.0 1.8e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 AIC15003.1 - 5.6e-05 22.3 0.0 0.0001 21.5 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 AIC15003.1 - 7.1e-05 22.2 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.1 AIC15003.1 - 0.0047 17.7 0.0 0.013 16.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.7 AIC15003.1 - 0.0071 15.7 0.0 0.013 14.8 0.0 1.4 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.10 AIC15003.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase PCMT PF01135.14 AIC15003.1 - 0.089 12.3 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FmrO PF07091.6 AIC15003.1 - 0.16 10.9 0.0 0.24 10.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) DUF2651 PF10852.3 AIC15004.1 - 0.0059 16.9 2.7 0.014 15.7 1.9 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2651) DUF98 PF01947.11 AIC15005.1 - 0.0006 19.5 0.0 0.012 15.4 0.0 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF98) Telomere_Sde2 PF13019.1 AIC15005.1 - 0.017 14.8 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 Telomere stability and silencing Tissue_fac PF01108.12 AIC15007.1 - 0.095 12.4 0.0 0.15 11.7 0.0 1.4 1 1 0 1 1 1 0 Tissue factor fn3 PF00041.16 AIC15007.1 - 0.12 12.5 0.1 0.35 11.0 0.1 1.8 1 1 0 1 1 1 0 Fibronectin type III domain NUDIX PF00293.23 AIC15009.1 - 4.5e-18 65.2 0.0 5.7e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.1 AIC15009.1 - 0.0018 17.6 0.0 0.0023 17.3 0.0 1.2 1 0 0 1 1 1 1 Nucleotide hydrolase Imm45 PF15603.1 AIC15009.1 - 0.014 15.5 0.0 0.025 14.7 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 45 Radical_SAM PF04055.16 AIC15010.1 - 9.9e-13 48.5 0.0 1.8e-12 47.7 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.14 AIC15010.1 - 0.035 13.9 0.0 0.32 10.8 0.0 2.2 2 0 0 2 2 2 0 B12 binding domain NAD_binding_1 PF00175.16 AIC15012.1 - 3.1e-12 47.0 0.0 6.5e-12 45.9 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.19 AIC15012.1 - 3.9e-12 46.1 0.0 5.9e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.7 AIC15012.1 - 0.047 13.5 0.1 0.094 12.6 0.1 1.8 1 1 0 1 1 1 0 Ferric reductase NAD binding domain Nup188 PF10487.4 AIC15013.1 - 0.056 11.3 0.2 0.052 11.4 0.1 1.0 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 DUF4584 PF15223.1 AIC15013.1 - 0.079 12.2 0.1 0.079 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4584) DUF1192 PF06698.6 AIC15013.1 - 0.14 11.9 0.6 0.81 9.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) FlgN PF05130.7 AIC15013.1 - 0.16 12.2 2.3 0.15 12.3 1.2 1.4 1 1 0 1 1 1 0 FlgN protein HAUS-augmin3 PF14932.1 AIC15013.1 - 0.23 10.6 3.6 0.29 10.2 2.5 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF1326 PF07040.6 AIC15016.1 - 1e-48 165.5 0.0 1.1e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) AAA PF00004.24 AIC15017.1 - 1.6e-94 313.0 0.0 2.4e-47 160.4 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 AIC15017.1 - 3.7e-27 94.0 0.3 1.2e-26 92.4 0.2 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_16 PF13191.1 AIC15017.1 - 1.7e-14 54.2 0.1 2.2e-06 27.7 0.0 3.4 2 1 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.9 AIC15017.1 - 2.2e-14 53.7 0.0 9e-06 25.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 AIC15017.1 - 3.6e-14 52.3 0.0 2.3e-08 33.3 0.0 2.4 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 AIC15017.1 - 1.3e-12 47.9 0.1 0.00011 22.3 0.0 4.1 2 2 1 3 3 3 2 AAA domain AAA_17 PF13207.1 AIC15017.1 - 6.7e-12 46.2 0.0 0.0001 23.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 AIC15017.1 - 3.5e-11 42.5 0.1 0.00019 20.5 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin TIP49 PF06068.8 AIC15017.1 - 1e-10 40.9 0.2 0.00015 20.6 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus AAA_14 PF13173.1 AIC15017.1 - 2.7e-10 40.2 0.0 0.00025 20.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 AIC15017.1 - 6.3e-10 39.0 0.0 0.001 18.9 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_5 PF07728.9 AIC15017.1 - 7.7e-10 38.6 1.0 0.00033 20.3 0.1 4.2 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.12 AIC15017.1 - 5.1e-08 32.5 0.4 0.0034 16.8 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.21 AIC15017.1 - 1.1e-06 28.1 0.1 0.087 12.2 0.0 3.3 3 1 0 3 3 3 2 Sigma-54 interaction domain NACHT PF05729.7 AIC15017.1 - 1.4e-06 28.0 0.0 0.078 12.6 0.0 3.5 4 0 0 4 4 3 2 NACHT domain AAA_18 PF13238.1 AIC15017.1 - 1.4e-06 28.6 0.0 0.026 14.8 0.0 2.8 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.16 AIC15017.1 - 2.1e-06 27.0 1.4 0.029 13.5 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.17 AIC15017.1 - 2.8e-06 27.4 0.0 0.039 14.1 0.0 2.5 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.1 AIC15017.1 - 3.5e-06 27.0 0.0 0.012 15.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AIC15017.1 - 7.9e-06 25.5 5.1 0.0053 16.4 0.1 3.4 3 0 0 3 3 2 2 Part of AAA domain ABC_tran PF00005.22 AIC15017.1 - 1.1e-05 25.7 0.1 0.088 13.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter Sigma54_activ_2 PF14532.1 AIC15017.1 - 3.4e-05 23.9 0.0 0.098 12.7 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain KaiC PF06745.8 AIC15017.1 - 5.5e-05 22.4 0.8 0.1 11.7 0.0 3.4 2 1 1 3 3 3 1 KaiC AAA_24 PF13479.1 AIC15017.1 - 5.7e-05 22.7 0.4 0.027 14.0 0.0 2.3 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.13 AIC15017.1 - 7.3e-05 22.5 0.0 0.066 12.8 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein AAA_25 PF13481.1 AIC15017.1 - 8e-05 22.1 5.5 0.51 9.7 0.2 4.0 2 2 2 4 4 4 2 AAA domain Arch_ATPase PF01637.13 AIC15017.1 - 8.6e-05 22.3 0.0 0.049 13.3 0.0 3.3 3 0 0 3 3 3 1 Archaeal ATPase UPF0079 PF02367.12 AIC15017.1 - 9.1e-05 22.0 0.0 0.14 11.7 0.0 2.5 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 PhoH PF02562.11 AIC15017.1 - 0.00015 21.1 0.3 0.17 11.1 0.0 2.4 2 0 0 2 2 2 2 PhoH-like protein CDC48_2 PF02933.12 AIC15017.1 - 0.00018 21.0 0.0 0.00087 18.8 0.0 2.1 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 NB-ARC PF00931.17 AIC15017.1 - 0.0002 20.3 0.0 0.42 9.4 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain AAA_3 PF07726.6 AIC15017.1 - 0.00084 18.9 0.0 0.52 9.9 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.8 AIC15017.1 - 0.001 18.0 0.0 0.38 9.6 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATP-synt_ab PF00006.20 AIC15017.1 - 0.0011 18.4 0.0 1.4 8.3 0.0 2.5 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain NTPase_1 PF03266.10 AIC15017.1 - 0.0021 17.8 1.6 5.3 6.7 0.0 3.9 4 1 1 5 5 3 0 NTPase SKI PF01202.17 AIC15017.1 - 0.0029 17.4 0.1 1.8 8.4 0.0 2.6 2 0 0 2 2 2 1 Shikimate kinase Guanylate_kin PF00625.16 AIC15017.1 - 0.0034 16.8 1.2 1.4 8.3 0.0 3.4 3 1 1 4 4 3 1 Guanylate kinase CPT PF07931.7 AIC15017.1 - 0.0037 16.9 0.0 0.38 10.3 0.0 2.6 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein T2SE PF00437.15 AIC15017.1 - 0.0039 16.1 0.0 2.3 7.0 0.0 2.3 2 0 0 2 2 2 1 Type II/IV secretion system protein DUF2075 PF09848.4 AIC15017.1 - 0.0043 16.0 0.1 0.51 9.2 0.0 2.6 3 0 0 3 3 2 1 Uncharacterized conserved protein (DUF2075) AFG1_ATPase PF03969.11 AIC15017.1 - 0.0058 15.4 0.0 1.6 7.4 0.0 2.8 3 0 0 3 3 3 1 AFG1-like ATPase AAA_30 PF13604.1 AIC15017.1 - 0.0065 16.0 0.1 4.4 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain ResIII PF04851.10 AIC15017.1 - 0.011 15.6 0.0 5 6.9 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_29 PF13555.1 AIC15017.1 - 0.011 15.2 0.7 1.6 8.3 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.1 AIC15017.1 - 0.014 15.7 0.1 2 8.7 0.0 2.5 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 AIC15017.1 - 0.02 14.0 0.0 1.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 Parvo_NS1 PF01057.12 AIC15017.1 - 0.021 13.7 0.1 0.49 9.2 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 PduV-EutP PF10662.4 AIC15017.1 - 0.054 12.9 0.0 4 6.9 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_10 PF12846.2 AIC15017.1 - 0.078 12.4 2.1 12 5.2 0.1 3.7 4 1 0 5 5 4 0 AAA-like domain AAA_11 PF13086.1 AIC15017.1 - 0.095 12.2 0.0 0.92 9.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain KAP_NTPase PF07693.9 AIC15017.1 - 0.14 11.1 0.3 8.1 5.3 0.0 2.8 2 2 2 4 4 4 0 KAP family P-loop domain cobW PF02492.14 AIC15017.1 - 0.17 11.2 0.2 23 4.3 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Viral_helicase1 PF01443.13 AIC15017.1 - 0.18 11.2 0.0 4.1 6.8 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Arginase PF00491.16 AIC15018.1 - 6.4e-27 94.5 0.0 8e-27 94.2 0.0 1.0 1 0 0 1 1 1 1 Arginase family FAA_hydrolase PF01557.13 AIC15020.1 - 7e-66 221.7 0.0 9.6e-66 221.3 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family tRNA-synt_1c PF00749.16 AIC15021.1 - 2.1e-76 256.5 0.0 2.7e-76 256.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.13 AIC15021.1 - 1.1e-30 106.5 0.0 1.9e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain polyprenyl_synt PF00348.12 AIC15022.1 - 1.9e-61 207.2 0.0 2.5e-61 206.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase BUD22 PF09073.5 AIC15022.1 - 0.13 11.3 0.1 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 BUD22 FMN_dh PF01070.13 AIC15023.1 - 1.4e-30 106.3 0.0 7.4e-22 77.6 0.0 2.0 1 1 1 2 2 2 2 FMN-dependent dehydrogenase Glu_synthase PF01645.12 AIC15023.1 - 0.00039 19.4 3.5 0.00082 18.3 2.4 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.20 AIC15023.1 - 0.0021 17.0 4.6 0.0086 14.9 0.1 2.8 2 1 1 3 3 3 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.10 AIC15023.1 - 0.0072 15.5 0.5 0.0072 15.5 0.3 1.6 2 0 0 2 2 2 1 Nitronate monooxygenase DHO_dh PF01180.16 AIC15023.1 - 0.37 9.7 2.6 2.6 6.9 1.8 2.4 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase AA_kinase PF00696.23 AIC15024.1 - 4.3e-28 98.4 2.7 5.3e-28 98.1 1.8 1.1 1 0 0 1 1 1 1 Amino acid kinase family TPR_1 PF00515.23 AIC15026.1 - 1e-29 100.9 7.7 1.5e-13 49.7 1.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.1 AIC15026.1 - 1.8e-29 101.2 5.2 2.8e-17 62.1 0.4 3.3 4 0 0 4 4 4 2 TPR repeat TPR_2 PF07719.12 AIC15026.1 - 1.7e-28 96.1 1.8 1.2e-10 40.4 0.4 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.1 AIC15026.1 - 7.7e-20 69.3 0.7 4.1e-06 26.5 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.1 AIC15026.1 - 1e-16 61.0 0.0 3.6e-06 27.4 0.0 4.1 2 1 1 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.1 AIC15026.1 - 6.5e-16 56.8 6.6 1.7e-08 33.6 0.3 5.2 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_9 PF13371.1 AIC15026.1 - 7.6e-14 51.3 0.1 8.7e-07 28.7 0.0 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.1 AIC15026.1 - 4.5e-13 48.9 0.1 3.2e-07 30.1 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat Apc3 PF12895.2 AIC15026.1 - 2.1e-12 46.9 5.1 2.4e-06 27.5 0.4 2.4 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.1 AIC15026.1 - 3.5e-11 42.7 0.0 0.0012 19.2 0.0 4.7 2 1 3 5 5 4 3 Tetratricopeptide repeat TPR_19 PF14559.1 AIC15026.1 - 1.9e-10 40.9 0.0 0.00077 19.7 0.0 2.9 2 1 0 3 3 2 2 Tetratricopeptide repeat TPR_7 PF13176.1 AIC15026.1 - 1.9e-08 33.4 0.1 0.0025 17.4 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.1 AIC15026.1 - 6.5e-08 32.3 0.1 0.005 16.6 0.0 3.2 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.1 AIC15026.1 - 6.5e-06 26.2 1.7 0.061 13.8 0.0 4.9 6 0 0 6 6 4 1 Tetratricopeptide repeat NARP1 PF12569.3 AIC15026.1 - 0.00015 20.6 0.1 0.07 11.8 0.0 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_20 PF14561.1 AIC15026.1 - 0.011 15.8 0.0 0.061 13.4 0.0 2.3 2 1 1 3 3 2 0 Tetratricopeptide repeat YfiO PF13525.1 AIC15026.1 - 0.052 13.0 0.1 0.61 9.5 0.1 2.3 1 1 1 2 2 2 0 Outer membrane lipoprotein DUF2250 PF10007.4 AIC15026.1 - 0.062 13.2 0.2 0.17 11.8 0.1 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) NAD_binding_5 PF07994.7 AIC15027.1 - 4.1e-24 85.5 0.0 7.1e-23 81.5 0.0 2.2 1 1 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.12 AIC15027.1 - 5.8e-14 51.8 0.0 1e-13 51.1 0.0 1.4 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase GFO_IDH_MocA PF01408.17 AIC15027.1 - 0.067 13.7 0.1 0.65 10.5 0.1 2.6 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold CoA_binding PF02629.14 AIC15027.1 - 0.094 13.2 1.6 10 6.7 1.1 2.8 1 1 0 1 1 1 0 CoA binding domain DUF4307 PF14155.1 AIC15028.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) Thi4 PF01946.12 AIC15029.1 - 2.4e-62 210.0 0.0 2.9e-62 209.7 0.0 1.0 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.19 AIC15029.1 - 2.6e-12 46.3 1.0 1.9e-07 30.2 0.2 2.7 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.2 AIC15029.1 - 6.6e-10 38.6 0.0 1e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 AIC15029.1 - 1.1e-08 34.4 1.2 1.7e-05 23.8 0.4 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 AIC15029.1 - 5.3e-08 32.3 0.1 7.6e-08 31.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.1 AIC15029.1 - 9.5e-08 31.9 0.1 1.9e-07 30.9 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.9 AIC15029.1 - 4.2e-07 30.0 0.2 8.2e-07 29.0 0.2 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 AIC15029.1 - 5.2e-06 25.1 0.1 7e-06 24.7 0.0 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.1 AIC15029.1 - 2.8e-05 24.2 0.1 4.1e-05 23.7 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 AIC15029.1 - 8.7e-05 21.6 0.5 0.00056 18.9 0.4 1.9 1 1 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.17 AIC15029.1 - 0.00019 20.4 0.8 0.0003 19.7 0.5 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.9 AIC15029.1 - 0.0011 17.7 0.3 0.41 9.2 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase ThiF PF00899.16 AIC15029.1 - 0.0089 15.8 0.4 0.028 14.2 0.1 1.9 2 1 1 3 3 3 1 ThiF family Amino_oxidase PF01593.19 AIC15029.1 - 0.018 14.1 0.0 0.028 13.5 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase NAD_binding_9 PF13454.1 AIC15029.1 - 0.052 13.3 0.2 0.099 12.4 0.2 1.4 1 0 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.22 AIC15029.1 - 0.095 13.1 0.5 0.36 11.2 0.3 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MacB_PCD PF12704.2 AIC15031.1 - 0.014 15.0 0.1 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 MacB-like periplasmic core domain IncA PF04156.9 AIC15031.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 IncA protein DUF1510 PF07423.6 AIC15031.1 - 0.016 14.6 0.0 0.021 14.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) Trp_oprn_chp PF09534.5 AIC15031.1 - 0.069 12.7 0.2 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) zf-UDP PF14569.1 AIC15032.1 - 0.039 13.6 0.0 0.41 10.4 0.0 2.2 2 0 0 2 2 2 0 Zinc-binding RING-finger Pyr_redox_2 PF07992.9 AIC15033.1 - 7.8e-34 117.3 4.6 5.9e-32 111.1 3.2 3.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 AIC15033.1 - 1.7e-19 69.9 0.5 1.7e-19 69.9 0.3 2.3 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 AIC15033.1 - 2.2e-18 67.0 0.4 3.2e-14 53.4 0.0 3.0 2 1 1 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 AIC15033.1 - 2.8e-09 36.3 3.6 0.00017 20.6 0.0 3.6 3 1 1 4 4 4 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AIC15033.1 - 1.8e-06 27.1 8.7 0.00035 19.5 0.2 4.4 2 2 3 5 5 5 2 FAD binding domain K_oxygenase PF13434.1 AIC15033.1 - 1.8e-06 27.1 0.1 0.014 14.3 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.12 AIC15033.1 - 7.1e-06 25.2 0.5 0.0014 17.7 0.0 2.7 3 0 0 3 3 3 1 Thi4 family GIDA PF01134.17 AIC15033.1 - 1.3e-05 24.2 7.5 0.022 13.6 0.1 4.7 3 2 2 5 5 5 2 Glucose inhibited division protein A FAD_binding_3 PF01494.14 AIC15033.1 - 1.5e-05 24.2 1.7 0.2 10.6 0.1 3.3 2 1 1 3 3 3 2 FAD binding domain NAD_binding_7 PF13241.1 AIC15033.1 - 6.2e-05 23.1 0.5 0.0076 16.4 0.4 2.5 2 1 0 2 2 2 1 Putative NAD(P)-binding FAD_oxidored PF12831.2 AIC15033.1 - 0.00016 20.9 1.3 0.0044 16.1 0.0 2.7 2 1 1 3 3 3 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AIC15033.1 - 0.00031 20.7 0.0 0.037 14.0 0.0 2.5 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 AIC15033.1 - 0.00031 19.3 1.7 0.034 12.6 0.1 3.2 3 1 0 3 3 3 1 HI0933-like protein NAD_binding_9 PF13454.1 AIC15033.1 - 0.0079 15.9 1.9 0.59 9.9 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 AIC15033.1 - 0.0084 15.0 0.8 0.83 8.5 0.0 3.1 3 1 0 3 3 3 1 Lycopene cyclase protein Shikimate_DH PF01488.15 AIC15033.1 - 0.038 14.0 0.2 0.28 11.2 0.0 2.4 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase XdhC_C PF13478.1 AIC15033.1 - 0.06 13.6 0.0 2.1 8.6 0.0 2.3 2 0 0 2 2 2 0 XdhC Rossmann domain Trp_halogenase PF04820.9 AIC15033.1 - 0.068 11.7 0.7 3.1 6.3 0.1 2.8 3 0 0 3 3 3 0 Tryptophan halogenase PALP PF00291.20 AIC15034.1 - 2.6e-54 184.5 0.0 3.4e-54 184.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CcmE PF03100.10 AIC15034.1 - 0.08 12.5 0.0 0.17 11.4 0.0 1.6 1 0 0 1 1 1 0 CcmE TusA PF01206.12 AIC15035.1 - 1.1e-23 82.5 0.0 1.3e-23 82.3 0.0 1.0 1 0 0 1 1 1 1 Sulfurtransferase TusA DUF2249 PF10006.4 AIC15035.1 - 0.011 15.2 0.0 0.018 14.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2249) Abhydrolase_6 PF12697.2 AIC15036.1 - 7.2e-38 130.7 0.0 8.5e-38 130.4 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AIC15036.1 - 1.4e-25 90.1 0.0 2.9e-25 89.1 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.2 AIC15036.1 - 8.7e-20 70.9 0.0 6.5e-19 68.1 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.11 AIC15036.1 - 3.9e-06 26.4 0.0 0.0025 17.3 0.0 2.5 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.3 AIC15036.1 - 5.4e-06 26.1 0.0 0.0016 18.2 0.0 2.4 2 0 0 2 2 2 1 Putative lysophospholipase Abhydrolase_4 PF08386.5 AIC15036.1 - 9.9e-05 22.1 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Thioesterase PF00975.15 AIC15036.1 - 0.00016 22.0 0.0 0.00021 21.6 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain DUF915 PF06028.6 AIC15036.1 - 0.00028 20.0 0.0 0.0024 17.0 0.0 2.0 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) DLH PF01738.13 AIC15036.1 - 0.00033 20.0 0.1 0.079 12.2 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF1057 PF06342.7 AIC15036.1 - 0.00064 18.6 0.0 0.0011 17.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) LIP PF03583.9 AIC15036.1 - 0.0022 17.2 0.0 0.36 9.9 0.0 2.1 1 1 0 1 1 1 1 Secretory lipase PGAP1 PF07819.8 AIC15036.1 - 0.0025 17.4 0.1 0.079 12.5 0.1 2.5 2 1 0 2 2 2 1 PGAP1-like protein Ser_hydrolase PF06821.8 AIC15036.1 - 0.0034 16.9 0.0 1.3 8.6 0.0 2.2 2 0 0 2 2 2 2 Serine hydrolase Lipase_3 PF01764.20 AIC15036.1 - 0.0067 16.0 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Esterase PF00756.15 AIC15036.1 - 0.011 15.2 0.0 0.016 14.6 0.0 1.2 1 0 0 1 1 1 0 Putative esterase FSH1 PF03959.8 AIC15036.1 - 0.017 14.5 0.5 0.99 8.8 0.1 2.7 1 1 0 2 2 2 0 Serine hydrolase (FSH1) BAAT_C PF08840.6 AIC15036.1 - 0.039 13.6 0.1 0.16 11.6 0.1 2.0 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF900 PF05990.7 AIC15036.1 - 0.046 13.0 0.0 0.098 11.9 0.0 1.7 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Abhydrolase_3 PF07859.8 AIC15036.1 - 0.074 12.6 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF726 PF05277.7 AIC15036.1 - 0.095 11.5 0.0 0.19 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF726) EHN PF06441.7 AIC15036.1 - 0.11 12.4 0.1 0.48 10.3 0.1 2.0 1 1 1 2 2 2 0 Epoxide hydrolase N terminus Ndr PF03096.9 AIC15036.1 - 0.15 10.5 0.0 0.16 10.3 0.0 1.3 1 1 0 1 1 1 0 Ndr family F420_ligase PF01996.11 AIC15037.1 - 6.9e-71 237.9 1.6 7.9e-71 237.7 1.1 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase HAD PF12710.2 AIC15038.1 - 3.3e-09 37.1 0.1 4.6e-09 36.7 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AIC15038.1 - 1.1e-08 35.7 0.8 4.6e-08 33.7 0.1 1.9 1 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 AIC15038.1 - 1.3e-06 28.7 0.0 2.2e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AIC15038.1 - 0.00012 21.7 0.1 0.00028 20.5 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 AIC15038.1 - 0.00075 18.8 0.0 0.001 18.4 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase VWA_2 PF13519.1 AIC15039.1 - 9.1e-11 42.1 0.0 6e-10 39.4 0.0 2.4 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.23 AIC15039.1 - 0.052 13.2 0.3 0.54 9.9 0.0 2.6 3 1 0 3 3 3 0 von Willebrand factor type A domain YlbD_coat PF14071.1 AIC15039.1 - 1.8 8.6 8.9 3.9 7.5 6.2 1.5 1 0 0 1 1 1 0 Putative coat protein OmpH PF03938.9 AIC15039.1 - 2.4 8.0 11.5 4.6 7.1 8.0 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_5 PF07728.9 AIC15040.1 - 4e-10 39.5 0.0 6.2e-06 25.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 AIC15040.1 - 1.7e-09 37.3 0.0 1e-06 28.3 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_3 PF07726.6 AIC15040.1 - 8.3e-07 28.6 0.0 6.8e-05 22.4 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.16 AIC15040.1 - 7.3e-05 22.0 0.0 0.33 10.0 0.0 2.7 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI AAA_PrkA PF08298.6 AIC15040.1 - 0.00024 19.9 0.1 0.0024 16.6 0.0 2.2 2 1 0 2 2 2 1 PrkA AAA domain MCM PF00493.18 AIC15040.1 - 0.00048 19.0 0.0 0.0056 15.5 0.0 2.2 2 0 0 2 2 2 1 MCM2/3/5 family AAA PF00004.24 AIC15040.1 - 0.048 13.8 0.0 2.1 8.5 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CbbQ_C PF08406.5 AIC15040.1 - 0.11 12.5 0.8 0.56 10.2 0.0 2.4 2 0 0 2 2 2 0 CbbQ/NirQ/NorQ C-terminal Ribosomal_S13 PF00416.17 AIC15042.1 - 3.2e-29 101.5 0.1 3.9e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 S4 PF01479.20 AIC15043.1 - 2.5e-13 49.2 4.6 2.8e-12 45.8 0.1 2.8 3 0 0 3 3 3 2 S4 domain Ribosomal_S4 PF00163.14 AIC15043.1 - 0.00018 21.7 3.9 0.00025 21.3 1.2 2.1 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain S_layer_C PF05124.7 AIC15044.1 - 3.1e-10 40.0 0.0 5.2e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 S-layer like family, C-terminal region HTH_20 PF12840.2 AIC15044.1 - 2.6e-09 36.7 0.0 4.8e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 AIC15044.1 - 3.3e-06 26.7 0.1 5.6e-06 25.9 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.2 AIC15044.1 - 0.0068 16.0 0.0 0.016 14.8 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_29 PF13551.1 AIC15044.1 - 0.047 13.8 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix HTH_27 PF13463.1 AIC15044.1 - 0.14 12.5 0.0 0.37 11.1 0.0 1.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain HTH_5 PF01022.15 AIC15044.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family SIS PF01380.17 AIC15045.1 - 1.5e-49 166.9 2.7 1.3e-25 89.5 0.7 2.4 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.1 AIC15045.1 - 1.6e-23 83.0 0.0 3.3e-23 82.1 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 AIC15045.1 - 1.9e-19 69.6 0.1 5.2e-15 55.0 0.1 2.8 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 AIC15045.1 - 4e-17 62.1 0.0 9.7e-17 60.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.1 AIC15045.1 - 1.3e-06 28.1 5.0 0.006 16.2 0.1 3.8 2 2 1 3 3 3 2 SIS domain GATase_4 PF13230.1 AIC15045.1 - 2.9e-05 22.8 0.0 4.4e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Snf7 PF03357.16 AIC15046.1 - 1.1e-07 31.4 0.3 1.6e-07 30.8 0.2 1.2 1 0 0 1 1 1 1 Snf7 DHC_N1 PF08385.7 AIC15046.1 - 0.00014 20.4 0.9 0.00017 20.1 0.6 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 LOH1CR12 PF10158.4 AIC15046.1 - 0.0024 17.6 0.5 0.0039 16.9 0.4 1.3 1 0 0 1 1 1 1 Tumour suppressor protein CK2S PF15011.1 AIC15046.1 - 0.049 13.4 1.1 0.13 12.0 0.7 1.7 1 1 1 2 2 2 0 Casein Kinase 2 substrate Matrilin_ccoil PF10393.4 AIC15046.1 - 0.062 12.6 0.5 0.062 12.6 0.3 2.3 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin IFT57 PF10498.4 AIC15046.1 - 0.13 11.0 4.9 0.19 10.4 3.4 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Baculo_PEP_C PF04513.7 AIC15046.1 - 0.17 11.7 2.5 1.2 8.9 0.2 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AHH PF14412.1 AIC15046.1 - 0.23 11.4 1.5 0.37 10.8 1.0 1.4 1 1 0 1 1 1 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH Nuc_rec_co-act PF08815.5 AIC15046.1 - 0.59 9.7 2.4 6.3 6.4 0.0 3.3 4 0 0 4 4 4 0 Nuclear receptor coactivator NPV_P10 PF05531.7 AIC15046.1 - 0.91 9.8 4.0 10 6.4 0.2 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein UPF0104 PF03706.8 AIC15048.1 - 4.3e-27 95.1 24.8 6.1e-27 94.6 17.2 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0104) K-cyclin_vir_C PF09080.5 AIC15048.1 - 0.0047 17.1 0.1 0.014 15.6 0.1 1.7 1 0 0 1 1 1 1 K cyclin, C terminal ATP_bind_1 PF03029.12 AIC15050.1 - 1.5e-52 178.4 0.0 1.7e-52 178.3 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.1 AIC15050.1 - 6.7e-05 22.9 0.0 0.00054 20.0 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain CbiA PF01656.18 AIC15050.1 - 0.00069 19.0 0.0 0.0012 18.3 0.0 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_10 PF12846.2 AIC15050.1 - 0.00088 18.7 0.0 0.0025 17.3 0.0 1.6 2 0 0 2 2 2 1 AAA-like domain AAA_22 PF13401.1 AIC15050.1 - 0.0028 17.7 0.0 0.0082 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 AIC15050.1 - 0.0053 15.5 0.1 0.04 12.6 0.0 2.0 2 0 0 2 2 2 1 ArgK protein AAA_17 PF13207.1 AIC15050.1 - 0.0056 17.4 0.0 0.012 16.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.4 AIC15050.1 - 0.0073 15.3 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) MMR_HSR1 PF01926.18 AIC15050.1 - 0.0089 15.9 0.0 0.039 13.9 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.1 AIC15050.1 - 0.017 15.4 0.2 0.037 14.3 0.0 1.8 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.4 AIC15050.1 - 0.035 12.7 0.0 0.053 12.1 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain cobW PF02492.14 AIC15050.1 - 0.059 12.8 0.3 8.8 5.7 0.0 2.2 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain NACHT PF05729.7 AIC15050.1 - 0.078 12.6 0.0 0.21 11.2 0.0 1.7 2 0 0 2 2 2 0 NACHT domain MobB PF03205.9 AIC15050.1 - 0.097 12.3 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B GHMP_kinases_N PF00288.21 AIC15051.1 - 1.6e-15 56.9 3.8 3.7e-15 55.7 2.0 2.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.8 AIC15051.1 - 9.5e-09 35.3 0.1 2.1e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal FlpD PF02662.11 AIC15051.1 - 0.029 14.0 0.1 0.068 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyl-viologen-reducing hydrogenase, delta subunit ECH PF00378.15 AIC15052.1 - 2.4e-68 229.9 4.3 2.8e-68 229.6 3.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase family ECH_C PF13766.1 AIC15052.1 - 0.0022 18.1 0.1 0.004 17.2 0.1 1.4 1 0 0 1 1 1 1 2-enoyl-CoA Hydratase C-terminal region Peptidase_S49 PF01343.13 AIC15052.1 - 0.0048 16.7 0.1 0.041 13.6 0.0 2.2 2 0 0 2 2 2 1 Peptidase family S49 Arginase PF00491.16 AIC15053.1 - 2.1e-61 207.6 0.2 2.4e-61 207.4 0.2 1.0 1 0 0 1 1 1 1 Arginase family ABC_membrane PF00664.18 AIC15055.1 - 0.057 12.8 0.1 0.079 12.3 0.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region E1-E2_ATPase PF00122.15 AIC15056.1 - 8.5e-54 182.0 2.5 2.4e-53 180.5 1.8 1.8 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 AIC15056.1 - 5.2e-51 174.1 6.3 1.1e-50 172.9 4.4 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.21 AIC15056.1 - 8.6e-26 89.8 0.5 5.7e-16 58.4 0.3 3.1 3 0 0 3 3 3 2 Heavy-metal-associated domain HAD PF12710.2 AIC15056.1 - 2e-15 57.4 0.0 1.3e-14 54.7 0.0 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.1 AIC15056.1 - 6.7e-05 22.7 0.1 0.045 13.6 0.0 3.4 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AIC15056.1 - 0.00026 20.6 5.1 0.017 14.7 1.0 3.1 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase PCP_red PF08369.5 AIC15056.1 - 0.05 13.4 0.2 0.14 12.0 0.2 1.8 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit DXPR_C PF13288.1 AIC15056.1 - 0.091 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 DXP reductoisomerase C-terminal domain DUF3673 PF12425.3 AIC15057.1 - 0.084 12.7 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) PAC2 PF09754.4 AIC15058.1 - 1.6e-23 83.7 0.0 2.1e-23 83.3 0.0 1.1 1 0 0 1 1 1 1 PAC2 family Oxysterol_BP PF01237.13 AIC15059.1 - 0.048 12.1 0.1 0.055 11.9 0.1 1.0 1 0 0 1 1 1 0 Oxysterol-binding protein DNA_ligase_A_M PF01068.16 AIC15062.1 - 1.6e-51 174.5 0.2 3.7e-51 173.3 0.1 1.6 2 0 0 2 2 2 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.9 AIC15062.1 - 4e-47 160.2 0.2 8.4e-47 159.2 0.0 1.6 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.10 AIC15062.1 - 1.7e-21 76.4 0.0 3.6e-21 75.3 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region Ribosomal_S25 PF03297.10 AIC15063.1 - 1.8e-06 27.9 4.8 2e-06 27.7 3.3 1.1 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.14 AIC15063.1 - 0.0016 18.1 0.2 0.0022 17.6 0.2 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF4355 PF14265.1 AIC15063.1 - 0.0081 16.1 1.6 0.01 15.8 1.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4355) MarR PF01047.17 AIC15063.1 - 0.0099 15.5 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.1 AIC15063.1 - 0.01 15.1 0.1 0.015 14.6 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC15063.1 - 0.02 14.5 0.0 0.025 14.2 0.0 1.2 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.15 AIC15063.1 - 0.037 14.1 0.6 0.05 13.7 0.4 1.3 1 1 0 1 1 1 0 Transcriptional regulator HTH_IclR PF09339.5 AIC15063.1 - 0.072 12.6 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_Crp_2 PF13545.1 AIC15063.1 - 0.076 12.8 0.0 0.093 12.5 0.0 1.2 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain PocR PF10114.4 AIC15063.1 - 0.12 11.5 0.1 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Sensory domain found in PocR Cyclophil_like PF04126.8 AIC15064.1 - 4.2e-09 36.0 0.0 6.5e-09 35.4 0.0 1.3 1 1 0 1 1 1 1 Cyclophilin-like ACP_syn_III PF08545.5 AIC15064.1 - 0.08 12.6 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III DUF3830 PF12903.2 AIC15064.1 - 0.098 12.0 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) RNA_pol_Rpb6 PF01192.17 AIC15066.1 - 1.7e-12 46.8 0.0 3e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 Raffinose_syn PF05691.7 AIC15066.1 - 0.11 9.9 0.0 0.12 9.8 0.0 1.0 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 Pyr_redox_2 PF07992.9 AIC15067.1 - 6.7e-35 120.7 6.7 2.2e-33 115.8 4.7 3.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 AIC15067.1 - 6.9e-25 87.2 0.1 1.3e-24 86.3 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 AIC15067.1 - 2.5e-15 56.6 2.3 6e-12 45.8 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.1 AIC15067.1 - 6.6e-10 39.3 0.2 7.3e-06 26.1 0.0 3.2 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.1 AIC15067.1 - 3.1e-07 29.6 1.0 7.8e-05 21.7 0.0 3.0 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.19 AIC15067.1 - 3.5e-05 22.8 4.9 0.00027 19.9 1.1 2.8 2 1 1 3 3 3 1 FAD binding domain GIDA PF01134.17 AIC15067.1 - 7.8e-05 21.6 0.6 0.00016 20.6 0.1 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A DAO PF01266.19 AIC15067.1 - 0.0048 15.8 3.3 0.012 14.5 0.1 2.6 3 0 0 3 3 3 1 FAD dependent oxidoreductase 3HCDH_N PF02737.13 AIC15067.1 - 0.0059 16.2 0.3 1.7 8.2 0.0 2.4 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Thi4 PF01946.12 AIC15067.1 - 0.0065 15.5 0.1 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Thi4 family XdhC_C PF13478.1 AIC15067.1 - 0.011 16.0 0.0 0.048 13.9 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain HI0933_like PF03486.9 AIC15067.1 - 0.022 13.2 0.8 0.09 11.2 0.3 2.0 2 0 0 2 2 2 0 HI0933-like protein FAD_oxidored PF12831.2 AIC15067.1 - 0.022 13.8 0.3 0.036 13.1 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AIC15067.1 - 0.38 10.8 3.4 4.7 7.3 0.3 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain HTH_20 PF12840.2 AIC15069.1 - 4.3e-09 36.0 0.0 8.1e-09 35.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_45 PF14947.1 AIC15069.1 - 2.8e-06 27.0 0.1 8.2e-06 25.5 0.1 1.8 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_24 PF13412.1 AIC15069.1 - 5.4e-06 25.7 0.8 1.2e-05 24.6 0.5 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC15069.1 - 5.5e-06 25.9 0.1 1.5e-05 24.5 0.0 1.7 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.1 AIC15069.1 - 0.00028 21.1 0.1 0.00076 19.7 0.0 1.8 2 0 0 2 2 2 1 Winged helix DNA-binding domain DUF4423 PF14394.1 AIC15069.1 - 0.00088 18.8 0.0 0.0021 17.6 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4423) TrmB PF01978.14 AIC15069.1 - 0.0019 17.8 0.0 0.0095 15.6 0.0 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.15 AIC15069.1 - 0.0022 17.5 0.1 0.0062 16.1 0.1 1.8 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF2250 PF10007.4 AIC15069.1 - 0.0028 17.5 0.2 0.012 15.4 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) MarR PF01047.17 AIC15069.1 - 0.0041 16.7 0.5 0.011 15.4 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_11 PF08279.7 AIC15069.1 - 0.0044 16.6 0.1 0.0089 15.6 0.0 1.5 1 0 0 1 1 1 1 HTH domain Regulator_TrmB PF11495.3 AIC15069.1 - 0.011 14.7 0.1 0.019 13.9 0.0 1.4 1 1 0 1 1 1 0 Archaeal transcriptional regulator TrmB Mrr_N PF14338.1 AIC15069.1 - 0.022 14.8 0.0 0.059 13.4 0.0 1.8 1 0 0 1 1 1 0 Mrr N-terminal domain HTH_34 PF13601.1 AIC15069.1 - 0.03 14.3 0.0 0.064 13.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain Fe_dep_repress PF01325.14 AIC15069.1 - 0.036 13.9 0.1 0.12 12.2 0.0 1.8 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain GCFC PF07842.7 AIC15069.1 - 0.069 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein XRCC4 PF06632.7 AIC15069.1 - 0.1 11.4 0.3 0.38 9.5 0.1 1.8 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 HTH_IclR PF09339.5 AIC15069.1 - 0.14 11.7 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain IncA PF04156.9 AIC15070.1 - 9.9e-05 22.0 0.2 0.00012 21.7 0.1 1.0 1 0 0 1 1 1 1 IncA protein TctB PF07331.6 AIC15070.1 - 0.00087 18.9 0.1 0.00092 18.8 0.1 1.0 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family DUF1469 PF07332.6 AIC15070.1 - 0.001 18.7 1.5 0.0012 18.5 1.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1469) UPF0104 PF03706.8 AIC15070.1 - 0.0024 17.2 0.2 0.0025 17.1 0.2 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0104) DUF998 PF06197.8 AIC15070.1 - 0.0033 16.7 1.6 0.0037 16.5 1.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF998) CitMHS PF03600.11 AIC15070.1 - 0.011 14.4 0.3 0.012 14.2 0.2 1.0 1 0 0 1 1 1 0 Citrate transporter DsbD_2 PF13386.1 AIC15070.1 - 0.023 14.4 0.1 0.024 14.3 0.1 1.0 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region DUF2371 PF10177.4 AIC15070.1 - 0.025 14.4 0.1 0.037 13.8 0.0 1.3 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) EmrE PF13536.1 AIC15070.1 - 0.037 14.2 2.0 0.043 14.0 1.4 1.2 1 0 0 1 1 1 0 Multidrug resistance efflux transporter DUF872 PF05915.7 AIC15070.1 - 0.037 13.8 2.0 0.07 12.9 0.1 1.9 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) NfeD PF01957.13 AIC15070.1 - 0.043 13.9 0.8 0.055 13.6 0.6 1.1 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding COPI_assoc PF08507.5 AIC15070.1 - 0.075 12.7 0.1 0.09 12.4 0.0 1.1 1 0 0 1 1 1 0 COPI associated protein DUF3185 PF11381.3 AIC15070.1 - 0.084 12.6 3.3 1.4 8.7 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3185) O-ag_pol_Wzy PF14296.1 AIC15070.1 - 0.09 11.3 0.0 0.1 11.1 0.0 1.0 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy TMEM51 PF15345.1 AIC15070.1 - 0.091 12.4 0.0 0.096 12.3 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 CRPA PF05745.6 AIC15070.1 - 0.19 11.5 0.9 0.23 11.2 0.6 1.1 1 0 0 1 1 1 0 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) SdpI PF13630.1 AIC15070.1 - 1.3 8.7 4.1 1.8 8.3 2.8 1.2 1 0 0 1 1 1 0 SdpI/YhfL protein family DUF202 PF02656.10 AIC15070.1 - 1.4 9.2 7.4 2.9 8.1 5.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF3188 PF11384.3 AIC15070.1 - 3 7.4 6.5 12 5.6 4.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3188) VPEP PF07589.6 AIC15070.1 - 3.2 7.7 7.4 0.84 9.6 0.5 2.2 2 0 0 2 2 2 0 PEP-CTERM motif HTH_3 PF01381.17 AIC15071.1 - 1.6e-05 24.6 0.2 4.7e-05 23.1 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.1 AIC15071.1 - 0.00029 20.5 0.0 0.00064 19.4 0.0 1.6 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.2 AIC15071.1 - 0.0007 19.5 0.1 0.0063 16.5 0.1 2.1 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_26 PF13443.1 AIC15071.1 - 0.0094 16.1 0.1 0.027 14.6 0.0 1.7 2 0 0 2 2 2 1 Cro/C1-type HTH DNA-binding domain P22_Cro PF14549.1 AIC15071.1 - 0.027 14.1 0.2 0.13 12.0 0.0 2.1 2 1 1 3 3 3 0 DNA-binding transcriptional regulator Cro Sigma70_r4_2 PF08281.7 AIC15071.1 - 0.044 13.2 0.1 0.19 11.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 MarR_2 PF12802.2 AIC15071.1 - 0.048 13.3 0.0 3.3 7.4 0.0 2.4 2 0 0 2 2 2 0 MarR family CPSase_L_D3 PF02787.14 AIC15071.1 - 0.066 12.9 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain DUF2666 PF10869.3 AIC15071.1 - 0.094 12.7 0.1 0.14 12.1 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2666) HTH_23 PF13384.1 AIC15071.1 - 0.097 12.3 0.0 0.39 10.4 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain F5_F8_type_C PF00754.20 AIC15072.1 - 2.4e-16 59.7 4.0 2.4e-16 59.7 2.8 2.5 3 0 0 3 3 3 1 F5/8 type C domain Big_3_4 PF13754.1 AIC15072.1 - 0.00014 22.1 2.0 0.00014 22.1 1.4 3.0 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 3) Sad1_UNC PF07738.8 AIC15072.1 - 0.004 16.9 0.0 0.0071 16.1 0.0 1.4 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal HYR PF02494.11 AIC15072.1 - 0.024 14.6 0.1 0.082 12.9 0.0 1.9 2 0 0 2 2 2 0 HYR domain Cas_Csy3 PF09615.5 AIC15072.1 - 0.16 11.0 0.1 0.33 9.9 0.1 1.4 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy3) ADH_N PF08240.7 AIC15073.1 - 5.6e-24 83.9 1.6 9.9e-24 83.2 1.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 AIC15073.1 - 1.9e-21 75.9 0.8 3.6e-21 75.0 0.0 1.8 2 0 0 2 2 2 1 Zinc-binding dehydrogenase HI0933_like PF03486.9 AIC15073.1 - 0.056 11.9 0.1 0.094 11.1 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein DeoC PF01791.4 AIC15074.1 - 8.6e-20 71.0 0.6 7e-19 68.0 0.0 1.9 1 1 1 2 2 2 1 DeoC/LacD family aldolase ThiG PF05690.9 AIC15074.1 - 0.06 12.4 0.1 0.08 12.0 0.1 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG SnoaL_3 PF13474.1 AIC15075.1 - 2e-11 43.9 0.0 2.6e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 AIC15075.1 - 1.2e-06 28.6 0.0 1.5e-06 28.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.1 AIC15075.1 - 0.00034 20.5 0.0 0.00049 20.0 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF3804 PF12707.2 AIC15075.1 - 0.005 16.4 0.1 0.0064 16.0 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3804) CaMKII_AD PF08332.5 AIC15075.1 - 0.016 15.1 0.0 0.024 14.5 0.0 1.3 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II Association Lumazine_bd_2 PF12893.2 AIC15075.1 - 0.051 14.1 0.0 0.081 13.4 0.0 1.5 1 1 0 1 1 1 0 Putative lumazine-binding TPP_enzyme_N PF02776.13 AIC15076.1 - 1.3e-62 210.3 1.2 8.8e-62 207.6 0.1 2.3 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.17 AIC15076.1 - 1.7e-45 154.1 0.1 4.8e-45 152.6 0.1 1.8 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.16 AIC15076.1 - 3.3e-45 153.4 0.7 6.6e-44 149.1 0.2 2.8 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain ALS_ss_C PF10369.4 AIC15077.1 - 2.2e-30 104.1 1.2 3e-28 97.3 0.0 2.8 2 1 0 2 2 2 1 Small subunit of acetolactate synthase ACT_5 PF13710.1 AIC15077.1 - 2.8e-20 71.8 1.0 9.8e-20 70.1 0.4 1.9 2 0 0 2 2 2 1 ACT domain ACT PF01842.20 AIC15077.1 - 9.2e-17 60.1 0.1 1.7e-16 59.2 0.0 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.1 AIC15077.1 - 5.1e-07 29.9 0.9 9.8e-07 29.0 0.6 1.4 1 0 0 1 1 1 1 ACT domain NIL PF09383.5 AIC15077.1 - 0.0018 17.8 0.2 0.44 10.1 0.0 2.3 2 0 0 2 2 2 2 NIL domain Saccharop_dh_N PF04455.7 AIC15077.1 - 0.01 15.9 0.4 0.022 14.8 0.2 1.6 1 1 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region ZipA_C PF04354.8 AIC15077.1 - 0.039 13.4 0.0 0.067 12.6 0.0 1.4 1 0 0 1 1 1 0 ZipA, C-terminal FtsZ-binding domain Acylphosphatase PF00708.13 AIC15077.1 - 0.047 13.7 0.0 2 8.5 0.0 2.2 2 0 0 2 2 2 0 Acylphosphatase ACT_6 PF13740.1 AIC15077.1 - 0.062 13.0 0.1 1.4 8.7 0.1 2.3 2 0 0 2 2 2 0 ACT domain Trans_reg_C PF00486.23 AIC15077.1 - 0.074 12.9 0.2 0.4 10.6 0.1 2.0 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal HMGL-like PF00682.14 AIC15078.1 - 2.3e-80 269.6 2.8 4.8e-80 268.6 1.9 1.5 1 0 0 1 1 1 1 HMGL-like LeuA_dimer PF08502.5 AIC15078.1 - 7.1e-31 106.7 2.8 1.6e-30 105.5 2.0 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Iso_dh PF00180.15 AIC15079.1 - 3.2e-98 328.9 0.3 3.7e-98 328.7 0.2 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.7 AIC15079.1 - 0.003 16.8 0.0 0.0061 15.8 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthetic protein PdxA zf-B_box PF00643.19 AIC15080.1 - 0.12 12.3 9.4 0.35 10.7 4.8 2.0 2 0 0 2 2 2 0 B-box zinc finger FlhC PF05280.6 AIC15080.1 - 3.8 6.9 6.8 4.9 6.5 4.7 1.2 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) FYVE_2 PF02318.11 AIC15080.1 - 3.9 7.4 8.0 5.3 6.9 5.6 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger zf-C3HC4_3 PF13920.1 AIC15080.1 - 6.3 6.5 12.5 16 5.2 8.6 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) MEDS PF14417.1 AIC15081.1 - 4.2e-11 42.2 0.1 5.9e-11 41.7 0.1 1.2 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Lipase_3 PF01764.20 AIC15081.1 - 0.082 12.5 0.0 1.3 8.5 0.0 2.5 3 0 0 3 3 3 0 Lipase (class 3) CPSase_sm_chain PF00988.17 AIC15083.1 - 1.8e-49 166.5 0.0 2.9e-49 165.8 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.23 AIC15083.1 - 1.2e-42 145.5 0.0 1.7e-42 145.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AIC15083.1 - 1e-09 38.1 0.1 1.9e-07 30.7 0.1 2.3 1 1 0 1 1 1 1 Peptidase C26 CPSase_L_D2 PF02786.12 AIC15084.1 - 3.2e-107 356.6 0.1 1e-74 250.4 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.14 AIC15084.1 - 9.9e-43 144.8 0.0 2e-42 143.8 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain ATP-grasp_4 PF13535.1 AIC15084.1 - 2.9e-31 108.6 0.0 3.2e-16 59.6 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_chain PF00289.17 AIC15084.1 - 5.4e-24 84.4 0.3 1.2e-17 63.9 0.0 3.6 5 0 0 5 5 3 2 Carbamoyl-phosphate synthase L chain, N-terminal domain ATPgrasp_Ter PF15632.1 AIC15084.1 - 2.9e-22 78.8 0.1 2.3e-13 49.5 0.0 3.8 2 2 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 AIC15084.1 - 5.9e-14 51.7 0.5 3.4e-06 26.5 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.17 AIC15084.1 - 6.9e-14 51.5 0.1 3.4e-13 49.3 0.0 2.3 3 0 0 3 3 2 1 MGS-like domain Dala_Dala_lig_C PF07478.8 AIC15084.1 - 1.6e-12 47.2 0.3 2.5e-09 36.8 0.0 2.6 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus RimK PF08443.6 AIC15084.1 - 2.9e-08 33.4 0.1 0.00019 20.9 0.0 2.7 2 1 0 2 2 2 2 RimK-like ATP-grasp domain GARS_A PF01071.14 AIC15084.1 - 3.2e-06 26.8 0.2 0.00033 20.2 0.0 2.8 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_3 PF02655.9 AIC15084.1 - 0.00032 20.6 0.2 0.024 14.5 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_5 PF13549.1 AIC15084.1 - 0.0011 18.2 0.1 1.2 8.2 0.0 2.6 2 0 0 2 2 2 2 ATP-grasp domain Peripla_BP_6 PF13458.1 AIC15084.1 - 0.038 13.3 0.0 0.89 8.8 0.0 2.5 2 0 0 2 2 2 0 Periplasmic binding protein Radical_SAM PF04055.16 AIC15085.1 - 1.6e-12 47.8 0.1 3e-12 47.0 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 AIC15085.1 - 3.4e-07 30.2 0.1 6.2e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPASM PF13186.1 AIC15085.1 - 0.00011 22.4 0.4 0.00035 20.8 0.3 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_12 PF13353.1 AIC15085.1 - 0.00022 21.3 0.0 0.00042 20.4 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Metallophos_2 PF12850.2 AIC15086.1 - 9.3e-08 32.0 0.0 1.6e-07 31.2 0.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 AIC15086.1 - 2.6e-07 30.2 0.2 1.3e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase SWIM PF04434.12 AIC15087.1 - 0.00035 19.9 0.2 0.00055 19.3 0.1 1.3 1 0 0 1 1 1 1 SWIM zinc finger FliW PF02623.10 AIC15087.1 - 0.12 11.9 0.0 0.76 9.3 0.0 1.8 1 1 1 2 2 2 0 FliW protein GARS_A PF01071.14 AIC15088.1 - 3.2e-78 261.7 0.4 4.6e-78 261.2 0.3 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.10 AIC15088.1 - 2.3e-31 108.2 0.0 4.8e-31 107.1 0.0 1.6 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.11 AIC15088.1 - 1.4e-26 92.4 0.4 4.2e-26 90.9 0.3 1.8 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_4 PF13535.1 AIC15088.1 - 2.8e-17 63.0 0.1 8.1e-17 61.5 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 AIC15088.1 - 5e-10 38.6 0.0 4.1e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.9 AIC15088.1 - 3.5e-07 30.2 0.0 7.2e-07 29.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.17 AIC15088.1 - 6.7e-06 25.5 0.1 1.7e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 AIC15088.1 - 1.5e-05 24.4 0.0 2.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.12 AIC15088.1 - 5e-05 22.6 0.5 0.00027 20.2 0.3 2.0 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain RimK PF08443.6 AIC15088.1 - 0.00023 20.6 0.0 0.0012 18.4 0.1 2.0 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_2 PF08442.5 AIC15088.1 - 0.0016 17.8 0.5 0.0035 16.7 0.4 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.1 AIC15088.1 - 0.043 12.8 0.1 0.12 11.4 0.0 1.7 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp 5-FTHF_cyc-lig PF01812.15 AIC15089.1 - 8.4e-33 113.6 0.0 9.9e-33 113.4 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family THF_DHG_CYH_C PF02882.14 AIC15090.1 - 9.1e-64 213.3 0.5 1.3e-63 212.8 0.3 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.18 AIC15090.1 - 3.3e-43 146.4 0.9 4.7e-43 145.9 0.2 1.5 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Semialdhyde_dh PF01118.19 AIC15090.1 - 0.0051 17.1 0.2 0.019 15.2 0.0 2.0 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 AIC15090.1 - 0.0055 16.8 0.2 0.022 14.8 0.1 2.0 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase CstA PF02554.9 AIC15091.1 - 0.0074 14.9 0.4 0.0083 14.8 0.3 1.1 1 0 0 1 1 1 1 Carbon starvation protein CstA 7TM_GPCR_Srd PF10317.4 AIC15091.1 - 0.058 12.3 1.8 0.074 12.0 1.2 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd Glycos_transf_2 PF00535.21 AIC15092.1 - 8.2e-21 74.4 0.0 1.2e-20 73.8 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AIC15092.1 - 1.1e-09 38.4 0.3 7.1e-09 35.7 0.0 1.8 1 1 1 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 AIC15092.1 - 0.00056 20.1 0.0 0.0013 18.9 0.0 1.7 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_5 PF13712.1 AIC15092.1 - 0.058 12.6 0.4 0.11 11.6 0.0 1.7 2 0 0 2 2 2 0 Glycosyltransferase like family Asn_synthase PF00733.16 AIC15093.1 - 7.3e-22 78.0 0.0 1.1e-21 77.5 0.0 1.1 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.11 AIC15093.1 - 0.016 13.8 0.0 0.022 13.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase NAD_synthase PF02540.12 AIC15093.1 - 0.1 11.4 0.0 0.19 10.5 0.0 1.4 1 0 0 1 1 1 0 NAD synthase DUF2899 PF11449.3 AIC15094.1 - 0.095 11.8 0.0 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2899) Cytochrom_B562 PF07361.6 AIC15094.1 - 0.64 10.4 10.3 1.6 9.2 0.1 3.1 1 1 2 3 3 3 0 Cytochrome b562 Uds1 PF15456.1 AIC15094.1 - 1.6 8.7 8.1 0.25 11.3 1.8 2.3 1 1 0 2 2 2 0 Up-regulated During Septation PSK_trans_fac PF07704.6 AIC15094.1 - 2.6 8.7 10.1 1.4 9.5 1.5 3.1 1 1 2 3 3 3 0 Rv0623-like transcription factor AAA_23 PF13476.1 AIC15094.1 - 2.8 8.2 6.4 4.6 7.4 4.4 1.4 1 1 0 1 1 1 0 AAA domain Matrilin_ccoil PF10393.4 AIC15094.1 - 3.4 7.1 6.2 3.2 7.2 0.1 2.6 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Ribosomal_L37e PF01907.14 AIC15095.1 - 1.6e-22 79.0 12.5 1.9e-22 78.8 8.7 1.0 1 0 0 1 1 1 1 Ribosomal protein L37e HypA PF01155.14 AIC15095.1 - 0.00094 18.8 0.8 0.001 18.7 0.6 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family DZR PF12773.2 AIC15095.1 - 0.0022 17.7 1.6 0.0027 17.4 1.1 1.2 1 0 0 1 1 1 1 Double zinc ribbon DNA_RNApol_7kD PF03604.8 AIC15095.1 - 0.0022 17.4 8.3 0.0043 16.4 1.2 2.2 2 0 0 2 2 2 1 DNA directed RNA polymerase, 7 kDa subunit Stc1 PF12898.2 AIC15095.1 - 0.0054 16.7 1.7 0.0055 16.7 1.2 1.1 1 0 0 1 1 1 1 Stc1 domain Ribosomal_S14 PF00253.16 AIC15095.1 - 0.0063 15.8 1.4 0.0063 15.8 0.9 2.1 1 1 1 2 2 2 1 Ribosomal protein S14p/S29e Zn-ribbon_8 PF09723.5 AIC15095.1 - 0.009 15.9 0.8 3.1 7.8 0.1 2.1 2 0 0 2 2 2 2 Zinc ribbon domain GCC2_GCC3 PF07699.8 AIC15095.1 - 0.012 15.1 3.0 0.019 14.5 2.1 1.4 1 0 0 1 1 1 0 GCC2 and GCC3 zinc_ribbon_6 PF14599.1 AIC15095.1 - 0.015 15.0 1.6 0.018 14.8 1.1 1.3 1 0 0 1 1 1 0 Zinc-ribbon zf-ribbon_3 PF13248.1 AIC15095.1 - 0.019 14.1 3.7 0.04 13.1 2.6 1.5 1 1 0 1 1 1 0 zinc-ribbon domain DUF35_N PF12172.3 AIC15095.1 - 0.036 13.9 3.5 0.048 13.5 2.5 1.2 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) OrfB_Zn_ribbon PF07282.6 AIC15095.1 - 0.041 13.5 3.9 0.051 13.2 2.7 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-NADH-PPase PF09297.6 AIC15095.1 - 0.055 12.9 5.7 0.15 11.6 0.2 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain NOB1_Zn_bind PF08772.6 AIC15095.1 - 0.06 13.1 3.9 0.12 12.2 2.7 1.5 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.1 AIC15095.1 - 0.075 12.5 6.7 0.13 11.8 4.5 1.5 1 1 0 1 1 1 0 zinc-ribbon domain Zn_Tnp_IS91 PF14319.1 AIC15095.1 - 0.075 12.5 2.9 0.078 12.4 2.0 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain LIM PF00412.17 AIC15095.1 - 0.09 12.8 5.4 0.24 11.4 3.7 1.8 1 1 0 1 1 1 0 LIM domain DnaJ_CXXCXGXG PF00684.14 AIC15095.1 - 0.16 11.9 4.6 0.22 11.6 3.2 1.1 1 0 0 1 1 1 0 DnaJ central domain Baculo_ME53 PF06061.6 AIC15095.1 - 0.24 10.3 3.1 0.25 10.3 2.2 1.0 1 0 0 1 1 1 0 Baculoviridae ME53 DUF2082 PF09855.4 AIC15095.1 - 0.27 11.0 3.8 3.2 7.6 0.2 2.2 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) NRDD PF13597.1 AIC15095.1 - 0.38 8.7 2.2 0.36 8.8 1.6 1.0 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase GFA PF04828.9 AIC15095.1 - 0.4 10.6 4.5 1.5 8.8 3.1 1.8 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme zinc_ribbon_4 PF13717.1 AIC15095.1 - 0.55 9.9 7.8 1.5 8.6 0.6 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TFIIS_C PF01096.13 AIC15095.1 - 0.59 9.8 6.0 7.1 6.3 0.5 2.4 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) zinc_ribbon_5 PF13719.1 AIC15095.1 - 0.86 9.2 8.0 1.8 8.1 0.7 2.2 2 0 0 2 2 2 0 zinc-ribbon domain UPF0547 PF10571.4 AIC15095.1 - 0.98 9.1 8.8 4.1 7.1 1.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-Mss51 PF13824.1 AIC15095.1 - 1.1 9.1 5.2 1.8 8.4 0.3 2.1 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 YhfH PF14149.1 AIC15095.1 - 3.6 7.4 8.2 7 6.5 0.4 2.2 1 1 1 2 2 2 0 YhfH-like protein RNA_POL_M_15KD PF02150.11 AIC15095.1 - 3.7 7.3 7.3 4.4 7.0 0.8 2.1 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit Zn_ribbon_recom PF13408.1 AIC15095.1 - 4.9 7.4 12.1 75 3.6 8.4 2.2 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain LSM PF01423.17 AIC15096.1 - 4.4e-22 77.3 1.6 5.1e-22 77.2 1.1 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.1 AIC15096.1 - 0.017 15.0 0.1 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 Ataxin 2 SM domain Creatininase PF02633.9 AIC15097.1 - 6.3e-65 218.5 1.1 7.6e-65 218.3 0.8 1.0 1 0 0 1 1 1 1 Creatinine amidohydrolase Formyl_trans_N PF00551.14 AIC15098.1 - 2.9e-45 154.0 0.0 4.1e-45 153.5 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT_6 PF13740.1 AIC15098.1 - 1.8e-10 40.3 0.1 3.8e-10 39.3 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT PF01842.20 AIC15098.1 - 5.8e-07 28.8 0.2 2.6e-06 26.7 0.0 2.1 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.1 AIC15098.1 - 6.2e-06 26.4 0.6 3.2e-05 24.1 0.1 2.3 3 0 0 3 3 3 1 ACT domain Tmemb_9 PF05434.6 AIC15101.1 - 0.028 14.1 0.5 0.037 13.7 0.3 1.2 1 0 0 1 1 1 0 TMEM9 CemA PF03040.9 AIC15103.1 - 0.0017 17.9 1.0 0.94 9.0 0.0 2.1 2 0 0 2 2 2 2 CemA family Sdh_cyt PF01127.17 AIC15103.1 - 1.2 8.9 5.4 3.9 7.3 3.8 1.7 1 1 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF3139 PF11337.3 AIC15103.1 - 4 7.7 9.3 14 6.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) DUF843 PF05814.6 AIC15103.1 - 6.4 6.6 7.3 4.2 7.2 0.1 2.1 2 0 0 2 2 2 0 Baculovirus protein of unknown function (DUF843) HTH_45 PF14947.1 AIC15104.1 - 6e-07 29.1 1.5 7.4e-07 28.8 1.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF2680 PF10925.3 AIC15104.1 - 0.013 15.3 0.4 6.1 6.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) MarR PF01047.17 AIC15104.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 MarR family Polyketide_cyc2 PF10604.4 AIC15106.1 - 6.6e-17 61.9 0.1 7.3e-17 61.8 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 AIC15106.1 - 4.2e-08 33.2 0.0 1.2e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.8 AIC15106.1 - 0.00038 20.1 0.0 0.0006 19.4 0.0 1.3 1 1 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) AHSA1 PF08327.6 AIC15106.1 - 0.0044 17.1 0.0 0.023 14.7 0.0 2.0 1 1 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DUF1857 PF08982.6 AIC15106.1 - 0.02 14.4 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1857) DUF2505 PF10698.4 AIC15106.1 - 0.14 11.6 0.2 2.2 7.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2505) DUF221 PF02714.10 AIC15107.1 - 0.033 13.0 0.1 0.041 12.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function DUF221 DUF4231 PF14015.1 AIC15107.1 - 0.91 9.5 3.6 2 8.4 2.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF4231) HBS1_N PF08938.5 AIC15108.1 - 0.098 12.7 0.1 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 HBS1 N-terminus SHOCT PF09851.4 AIC15109.1 - 1.2e-08 34.1 0.3 1.5e-08 33.8 0.2 1.2 1 0 0 1 1 1 1 Short C-terminal domain Tic20 PF09685.5 AIC15109.1 - 0.45 10.5 4.5 0.57 10.1 3.1 1.1 1 0 0 1 1 1 0 Tic20-like protein Sec62 PF03839.11 AIC15109.1 - 2.5 7.4 4.3 2.6 7.3 3.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 HxlR PF01638.12 AIC15110.1 - 6.8e-23 80.1 0.2 8.2e-23 79.8 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.1 AIC15110.1 - 0.00014 21.8 0.0 0.00019 21.3 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_20 PF12840.2 AIC15110.1 - 0.049 13.4 0.1 0.073 12.8 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain MarR PF01047.17 AIC15110.1 - 0.075 12.7 0.1 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 MarR family Glyco_trans_1_4 PF13692.1 AIC15111.1 - 7.6e-11 42.3 0.0 2.1e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 AIC15111.1 - 1.7e-08 34.7 3.0 1.8e-07 31.4 2.1 2.1 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_transf_4 PF13439.1 AIC15111.1 - 3.7e-07 30.0 0.9 1e-06 28.6 0.6 1.6 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_2 PF13524.1 AIC15111.1 - 0.00011 22.4 0.0 0.00034 20.8 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.1 AIC15111.1 - 0.0025 17.6 0.0 0.0053 16.5 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like PIG-L PF02585.12 AIC15111.1 - 0.066 13.7 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase Synapsin PF02078.11 AIC15111.1 - 0.071 13.2 0.0 0.18 11.9 0.0 1.7 1 0 0 1 1 1 0 Synapsin, N-terminal domain Glyco_trans_4_4 PF13579.1 AIC15112.1 - 0.0065 16.6 0.2 0.016 15.3 0.1 1.7 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.1 AIC15112.1 - 0.071 12.9 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase 4-like Methyltransf_23 PF13489.1 AIC15113.1 - 1.6e-16 60.4 0.1 3.3e-16 59.4 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15113.1 - 1.6e-12 47.2 0.0 2.2e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15113.1 - 1.8e-10 41.1 0.0 3e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC15113.1 - 3e-09 37.2 0.0 4.8e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15113.1 - 3.1e-09 37.0 0.0 4.7e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15113.1 - 6.4e-08 33.1 0.0 1.1e-07 32.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.6 AIC15113.1 - 1.1e-07 31.4 0.0 1.5e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.9 AIC15113.1 - 5e-06 25.9 0.1 2.2e-05 23.9 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain NNMT_PNMT_TEMT PF01234.12 AIC15113.1 - 0.00035 19.6 0.1 0.0014 17.6 0.0 1.8 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family Ubie_methyltran PF01209.13 AIC15113.1 - 0.00053 19.1 0.1 0.00072 18.7 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Pox_MCEL PF03291.11 AIC15113.1 - 0.0017 17.2 1.0 0.0064 15.4 0.7 1.7 1 1 0 1 1 1 1 mRNA capping enzyme Methyltransf_26 PF13659.1 AIC15113.1 - 0.0031 17.5 0.0 0.014 15.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.6 AIC15113.1 - 0.004 15.8 0.0 0.0054 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Bin3 PF06859.7 AIC15113.1 - 0.051 13.5 0.0 0.1 12.5 0.0 1.6 1 1 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) Epimerase_2 PF02350.14 AIC15114.1 - 3.2e-96 322.1 0.0 3.9e-96 321.8 0.0 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase DUF354 PF04007.7 AIC15114.1 - 0.00058 18.8 0.0 0.00085 18.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF354) Ribonucleas_3_2 PF11469.3 AIC15118.1 - 0.037 14.2 0.0 0.071 13.3 0.0 1.5 1 0 0 1 1 1 0 Ribonuclease III DUF3734 PF12536.3 AIC15118.1 - 0.039 14.0 0.1 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Patatin phospholipase SnoaL_2 PF12680.2 AIC15119.1 - 2e-05 24.8 0.3 2.6e-05 24.5 0.2 1.3 1 1 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.1 AIC15119.1 - 0.054 13.5 0.1 0.074 13.0 0.0 1.2 1 1 0 1 1 1 0 SnoaL-like domain SnoaL_4 PF13577.1 AIC15119.1 - 0.058 13.3 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain DUF1396 PF07161.8 AIC15121.1 - 0.034 13.8 0.2 1.3 8.6 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1396) PvlArgDC PF01862.11 AIC15123.1 - 1.1e-60 204.0 0.0 1.2e-60 203.8 0.0 1.0 1 0 0 1 1 1 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) IF3_N PF05198.11 AIC15123.1 - 0.059 13.3 0.1 0.14 12.1 0.0 1.6 2 0 0 2 2 2 0 Translation initiation factor IF-3, N-terminal domain DUF2015 PF09435.5 AIC15124.1 - 0.0068 16.1 1.1 0.4 10.4 0.3 2.5 2 0 0 2 2 2 1 Fungal protein of unknown function (DUF2015) Baculo_11_kDa PF06143.6 AIC15124.1 - 0.0095 15.2 1.3 0.032 13.5 0.9 2.0 1 0 0 1 1 1 1 Baculovirus 11 kDa family DUF485 PF04341.7 AIC15124.1 - 0.019 14.6 0.6 0.04 13.6 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Peptidase_S49_N PF08496.5 AIC15124.1 - 0.024 14.4 0.6 0.04 13.7 0.4 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pox_LP_H2 PF03356.10 AIC15124.1 - 0.028 14.1 1.7 0.045 13.4 1.1 1.3 1 0 0 1 1 1 0 Viral late protein H2 DUF4381 PF14316.1 AIC15124.1 - 0.034 14.2 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF3481 PF11980.3 AIC15124.1 - 0.048 13.5 0.1 5.5 6.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3481) Chordopox_A13L PF05961.6 AIC15124.1 - 0.061 13.2 0.6 0.17 11.8 0.4 1.8 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF912 PF06024.7 AIC15124.1 - 0.068 13.2 2.5 0.11 12.5 0.9 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF912) IncA PF04156.9 AIC15124.1 - 0.076 12.6 2.1 0.24 10.9 1.5 1.8 1 1 0 1 1 1 0 IncA protein DUF4320 PF14208.1 AIC15124.1 - 0.085 12.8 1.2 0.3 11.0 0.2 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4320) DUF4446 PF14584.1 AIC15124.1 - 0.15 11.9 1.9 0.25 11.1 0.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) ASFV_J13L PF05568.6 AIC15124.1 - 0.16 11.4 3.2 0.28 10.7 2.2 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein CARDB PF07705.6 AIC15124.1 - 0.22 11.5 2.3 0.73 9.9 1.6 1.8 1 1 0 1 1 1 0 CARDB ABC2_membrane_3 PF12698.2 AIC15124.1 - 0.26 10.2 5.4 0.026 13.5 0.6 1.6 2 0 0 2 2 2 0 ABC-2 family transporter protein FixQ PF05545.6 AIC15124.1 - 0.6 9.8 5.4 19 4.9 3.7 2.4 1 1 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ HemY_N PF07219.8 AIC15124.1 - 2.7 7.5 5.3 0.59 9.7 0.9 1.9 2 0 0 2 2 2 0 HemY protein N-terminus Rifin_STEVOR PF02009.11 AIC15124.1 - 8.5 5.9 14.8 1.1 8.8 6.5 1.9 1 1 1 2 2 2 0 Rifin/stevor family HTH_45 PF14947.1 AIC15130.1 - 0.0077 16.0 0.1 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix Piwi PF02171.12 AIC15131.1 - 7.1e-11 41.6 0.0 1.3e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 Piwi domain AAA_23 PF13476.1 AIC15133.1 - 6.4e-11 42.9 62.5 1.2e-08 35.5 26.9 5.3 1 1 1 2 2 2 1 AAA domain SMC_N PF02463.14 AIC15133.1 - 2.6e-09 36.6 20.7 4.1e-08 32.7 14.3 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 AIC15133.1 - 0.00019 20.5 0.0 0.00019 20.5 0.0 3.4 3 2 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.1 AIC15133.1 - 0.00097 18.6 0.0 0.0024 17.3 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.1 AIC15133.1 - 0.0018 18.2 0.4 0.025 14.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain AAA PF00004.24 AIC15133.1 - 0.01 16.0 0.3 0.086 13.0 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.7 AIC15133.1 - 0.041 13.5 5.4 2.2 7.8 0.3 3.7 4 0 0 4 4 4 0 NACHT domain ABC_tran PF00005.22 AIC15133.1 - 0.041 14.1 0.1 0.041 14.1 0.0 4.2 3 2 1 4 4 4 0 ABC transporter DnaJ_CXXCXGXG PF00684.14 AIC15134.1 - 4.7e-05 23.3 2.0 0.00011 22.1 1.4 1.6 1 1 0 1 1 1 1 DnaJ central domain Lar_restr_allev PF14354.1 AIC15134.1 - 0.0027 17.9 0.4 0.0053 17.0 0.2 1.4 1 0 0 1 1 1 1 Restriction alleviation protein Lar zf-TFIIB PF13453.1 AIC15134.1 - 0.0078 15.3 1.3 0.022 13.9 0.9 1.8 1 1 0 1 1 1 1 Transcription factor zinc-finger Mut7-C PF01927.11 AIC15134.1 - 0.046 13.7 0.3 0.091 12.7 0.2 1.7 1 1 0 1 1 1 0 Mut7-C RNAse domain zinc_ribbon_2 PF13240.1 AIC15134.1 - 0.063 12.7 0.8 3.5 7.2 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zf-RING_3 PF14369.1 AIC15134.1 - 0.068 13.1 5.8 3 7.9 0.5 2.3 1 1 1 2 2 2 0 zinc-finger Zn-ribbon_8 PF09723.5 AIC15134.1 - 0.14 12.1 0.6 11 6.0 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-HC2 PF13490.1 AIC15134.1 - 0.26 11.2 0.1 0.26 11.2 0.1 3.4 3 0 0 3 3 3 0 Putative zinc-finger DUF1356 PF07092.7 AIC15134.1 - 0.37 9.9 1.9 1.3 8.1 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) zf-C4_Topoisom PF01396.14 AIC15134.1 - 0.64 9.5 2.9 9.6 5.8 0.4 2.2 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Strep_SA_rep PF06696.6 AIC15136.1 - 0.061 13.0 0.2 0.1 12.3 0.1 1.3 1 0 0 1 1 1 0 Streptococcal surface antigen repeat HTH_45 PF14947.1 AIC15136.1 - 0.083 12.7 0.0 12 5.7 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix AAA_16 PF13191.1 AIC15137.1 - 0.0072 16.3 0.0 0.023 14.6 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_12 PF13087.1 AIC15138.1 - 2e-21 76.2 0.0 5.4e-21 74.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.1 AIC15138.1 - 5.5e-16 58.8 0.0 1e-07 31.7 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AIC15138.1 - 1.2e-12 47.3 0.2 3.4e-12 45.9 0.1 1.8 1 0 0 1 1 1 1 Part of AAA domain DUF4011 PF13195.1 AIC15138.1 - 9.8e-11 41.9 0.0 2.5e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4011) zinc_ribbon_2 PF13240.1 AIC15138.1 - 1.1e-07 31.0 4.4 2.3e-07 30.0 3.0 1.5 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC15138.1 - 2.9e-06 26.2 3.1 5.5e-06 25.4 2.1 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DUF2075 PF09848.4 AIC15138.1 - 1.7e-05 23.9 0.5 0.0037 16.2 0.0 3.6 4 0 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) DZR PF12773.2 AIC15138.1 - 6.1e-05 22.7 1.7 0.00012 21.8 1.2 1.4 1 0 0 1 1 1 1 Double zinc ribbon AAA_30 PF13604.1 AIC15138.1 - 0.00018 21.1 0.0 0.0048 16.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain DUF559 PF04480.7 AIC15138.1 - 0.00049 19.7 0.0 0.0015 18.1 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF559) PhoH PF02562.11 AIC15138.1 - 0.00053 19.2 0.0 0.024 13.8 0.0 2.7 2 0 0 2 2 2 1 PhoH-like protein Viral_helicase1 PF01443.13 AIC15138.1 - 0.00089 18.8 0.1 0.23 10.9 0.0 3.2 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase DEAD PF00270.24 AIC15138.1 - 0.0025 17.3 0.7 0.037 13.5 0.0 2.7 2 1 0 2 2 2 1 DEAD/DEAH box helicase UPF0547 PF10571.4 AIC15138.1 - 0.0048 16.5 2.7 0.0094 15.6 1.9 1.5 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 Zot PF05707.7 AIC15138.1 - 0.0063 15.9 0.3 0.058 12.8 0.1 2.4 2 0 0 2 2 2 1 Zonular occludens toxin (Zot) AAA_16 PF13191.1 AIC15138.1 - 0.0076 16.2 0.0 0.034 14.1 0.0 2.2 1 0 0 1 1 1 1 AAA ATPase domain ArgK PF03308.11 AIC15138.1 - 0.011 14.4 0.1 0.045 12.5 0.0 1.9 2 0 0 2 2 2 0 ArgK protein IstB_IS21 PF01695.12 AIC15138.1 - 0.019 14.3 0.0 0.068 12.5 0.0 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein TrwB_AAD_bind PF10412.4 AIC15138.1 - 0.024 13.2 0.0 0.045 12.3 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Herpes_ori_bp PF02399.10 AIC15138.1 - 0.031 12.2 0.0 0.049 11.5 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein DAP3 PF10236.4 AIC15138.1 - 0.042 12.7 0.0 0.078 11.8 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 UvrD_C_2 PF13538.1 AIC15138.1 - 0.057 13.5 0.0 0.18 11.9 0.0 1.9 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain AAA_22 PF13401.1 AIC15138.1 - 0.064 13.3 0.2 0.6 10.2 0.0 2.7 2 0 0 2 2 2 0 AAA domain UvrD-helicase PF00580.16 AIC15138.1 - 0.071 12.3 0.0 0.64 9.2 0.0 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain AAA_25 PF13481.1 AIC15138.1 - 0.072 12.4 0.0 0.28 10.5 0.0 2.1 1 0 0 1 1 1 0 AAA domain ResIII PF04851.10 AIC15138.1 - 0.077 12.8 0.0 1.4 8.7 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_5 PF07728.9 AIC15138.1 - 0.098 12.3 0.2 2.2 8.0 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF1236 PF06823.7 AIC15138.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1236) FtsK_SpoIIIE PF01580.13 AIC15138.1 - 0.14 11.6 0.0 0.35 10.3 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Helicase_RecD PF05127.9 AIC15138.1 - 0.15 11.6 0.0 0.38 10.3 0.0 1.7 1 0 0 1 1 1 0 Helicase UvrD-helicase PF00580.16 AIC15139.1 - 6.9e-64 216.1 0.1 6.9e-64 216.1 0.1 2.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.1 AIC15139.1 - 1.8e-52 178.9 1.1 1.8e-52 178.9 0.8 3.2 4 1 0 4 4 4 1 UvrD-like helicase C-terminal domain PDDEXK_1 PF12705.2 AIC15139.1 - 2.6e-43 148.2 1.1 5.5e-43 147.2 0.2 2.0 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily AAA_19 PF13245.1 AIC15139.1 - 4.7e-14 51.8 0.1 1.9e-13 49.9 0.0 2.0 2 0 0 2 2 2 1 Part of AAA domain UvrD_C_2 PF13538.1 AIC15139.1 - 6.7e-11 42.2 2.2 3.6e-10 39.8 0.2 2.9 2 1 0 2 2 1 1 UvrD-like helicase C-terminal domain Cas_Cas4 PF01930.12 AIC15139.1 - 2.3e-06 27.6 0.8 1.3e-05 25.1 0.1 2.8 2 1 1 3 3 3 1 Domain of unknown function DUF83 Viral_helicase1 PF01443.13 AIC15139.1 - 4.1e-06 26.4 1.1 0.18 11.3 0.0 4.2 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.1 AIC15139.1 - 1e-05 25.1 0.0 3.5e-05 23.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.1 AIC15139.1 - 9.9e-05 21.8 0.1 0.0019 17.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain AAA_11 PF13086.1 AIC15139.1 - 0.00074 19.1 0.8 0.00074 19.1 0.6 3.5 3 2 0 3 3 3 1 AAA domain AAA_16 PF13191.1 AIC15139.1 - 0.08 12.9 2.1 1.2 9.0 0.0 3.2 3 1 0 3 3 3 0 AAA ATPase domain Methyltransf_26 PF13659.1 AIC15140.1 - 8.4e-11 41.9 0.0 2e-10 40.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Eco57I PF07669.6 AIC15140.1 - 3.5e-08 33.7 0.1 2.1e-06 28.0 0.0 3.3 3 1 0 3 3 3 1 Eco57I restriction-modification methylase N6_Mtase PF02384.11 AIC15140.1 - 4.1e-06 26.1 1.0 0.086 11.8 0.0 4.8 4 1 0 4 4 4 2 N-6 DNA Methylase TaqI_C PF12950.2 AIC15140.1 - 0.0003 20.5 0.0 0.00077 19.2 0.0 1.7 1 0 0 1 1 1 1 TaqI-like C-terminal specificity domain SNF2_N PF00176.18 AIC15141.1 - 1.3e-16 60.2 0.1 9.4e-11 41.0 0.0 3.2 1 1 1 3 3 3 2 SNF2 family N-terminal domain Helicase_C PF00271.26 AIC15141.1 - 1.3e-16 60.1 0.0 4.8e-16 58.3 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PLDc_2 PF13091.1 AIC15141.1 - 7.1e-16 58.0 1.4 1e-14 54.3 0.3 2.8 2 0 0 2 2 2 1 PLD-like domain ResIII PF04851.10 AIC15141.1 - 1.2e-12 48.0 0.0 5.5e-06 26.3 0.0 3.5 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit DEAD PF00270.24 AIC15141.1 - 1.6e-09 37.5 0.2 7.2e-05 22.3 0.0 3.2 2 1 0 3 3 3 2 DEAD/DEAH box helicase Flavi_DEAD PF07652.9 AIC15141.1 - 0.00014 21.6 0.2 0.01 15.5 0.1 2.7 1 1 0 1 1 1 1 Flavivirus DEAD domain PLDc PF00614.17 AIC15141.1 - 0.00041 20.0 0.1 0.0083 15.9 0.0 2.6 2 0 0 2 2 2 1 Phospholipase D Active site motif DUF2075 PF09848.4 AIC15141.1 - 0.001 18.1 0.3 0.0043 16.0 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NMT PF01233.14 AIC15141.1 - 0.03 13.9 0.1 0.077 12.6 0.1 1.7 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain DUF3655 PF12379.3 AIC15141.1 - 7.3 6.6 9.3 0.093 12.6 0.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3655) HD PF01966.17 AIC15142.1 - 4.6e-10 39.5 0.5 1.5e-09 37.9 0.4 2.0 1 0 0 1 1 1 1 HD domain Radical_SAM PF04055.16 AIC15144.1 - 0.0002 21.5 0.1 0.0029 17.8 0.1 2.4 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 AIC15144.1 - 0.043 13.9 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain Gp37_Gp68 PF07505.6 AIC15145.1 - 4.8e-56 189.8 0.0 5.7e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 Phage protein Gp37/Gp68 Cdc6_C PF09079.6 AIC15146.1 - 1.9e-09 37.1 0.1 2.6e-08 33.4 0.1 2.5 3 0 0 3 3 3 1 CDC6, C terminal AAA_22 PF13401.1 AIC15146.1 - 1.4e-08 34.9 0.1 4e-08 33.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 AIC15146.1 - 3.1e-06 27.2 0.1 3.5e-05 23.8 0.0 2.4 2 1 0 2 2 2 1 AAA ATPase domain Bac_DnaA PF00308.13 AIC15146.1 - 0.00034 20.3 0.1 0.00092 18.9 0.1 1.6 1 1 0 1 1 1 1 Bacterial dnaA protein AAA PF00004.24 AIC15146.1 - 0.0029 17.7 0.1 0.0088 16.2 0.0 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 AIC15146.1 - 0.0043 16.7 2.1 0.0067 16.1 0.2 2.2 2 1 0 2 2 2 1 Archaeal ATPase AAA_24 PF13479.1 AIC15146.1 - 0.037 13.6 0.6 0.11 12.0 0.4 1.8 1 1 0 1 1 1 0 AAA domain HTH_20 PF12840.2 AIC15147.1 - 4.9e-07 29.4 0.0 7e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.15 AIC15147.1 - 2.2e-05 24.4 0.1 2.9e-05 24.0 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator HTH_5 PF01022.15 AIC15147.1 - 0.00068 19.2 1.8 0.002 17.7 1.2 1.8 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family RepL PF05732.6 AIC15147.1 - 0.004 16.3 0.0 0.0041 16.3 0.0 1.2 1 0 0 1 1 1 1 Firmicute plasmid replication protein (RepL) HTH_36 PF13730.1 AIC15147.1 - 0.0062 16.6 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 AIC15147.1 - 0.0067 16.1 0.0 0.0084 15.8 0.0 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.1 AIC15147.1 - 0.0087 16.0 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF1495 PF07381.6 AIC15147.1 - 0.012 15.2 0.3 0.048 13.3 0.2 1.8 1 1 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) HTH_45 PF14947.1 AIC15147.1 - 0.019 14.7 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DUF4423 PF14394.1 AIC15147.1 - 0.028 13.9 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) MarR_2 PF12802.2 AIC15147.1 - 0.041 13.5 0.0 0.06 13.0 0.0 1.2 1 0 0 1 1 1 0 MarR family B-block_TFIIIC PF04182.7 AIC15147.1 - 0.048 13.5 0.1 0.062 13.1 0.0 1.2 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC DUF2513 PF10711.4 AIC15147.1 - 0.062 13.3 0.0 0.08 13.0 0.0 1.2 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) Cullin PF00888.17 AIC15147.1 - 0.085 11.3 0.0 0.098 11.1 0.0 1.1 1 0 0 1 1 1 0 Cullin family HTH_23 PF13384.1 AIC15147.1 - 0.11 12.1 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_24 PF13412.1 AIC15147.1 - 0.12 11.8 0.6 0.18 11.1 0.1 1.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.7 AIC15147.1 - 0.13 11.9 0.0 0.18 11.4 0.0 1.2 1 0 0 1 1 1 0 HTH domain HTH_IclR PF09339.5 AIC15148.1 - 1.5e-06 27.7 0.0 3.1e-06 26.6 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.2 AIC15148.1 - 2e-05 24.1 0.0 3.3e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 MarR family SpoIIID PF12116.3 AIC15148.1 - 0.00028 20.7 0.0 0.00058 19.7 0.0 1.5 1 0 0 1 1 1 1 Stage III sporulation protein D TrmB PF01978.14 AIC15148.1 - 0.00035 20.2 0.0 0.00058 19.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC15148.1 - 0.00058 19.1 0.0 0.0011 18.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_28 PF13518.1 AIC15148.1 - 0.0012 18.7 0.0 0.0023 17.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_10 PF04967.7 AIC15148.1 - 0.0023 17.4 0.0 0.0039 16.7 0.0 1.3 1 0 0 1 1 1 1 HTH DNA binding domain HTH_20 PF12840.2 AIC15148.1 - 0.0037 17.0 0.1 0.0066 16.2 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Fe_dep_repress PF01325.14 AIC15148.1 - 0.004 17.0 0.0 0.0083 16.0 0.0 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_5 PF01022.15 AIC15148.1 - 0.011 15.3 0.0 0.025 14.2 0.0 1.6 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family GntR PF00392.16 AIC15148.1 - 0.011 15.1 0.1 0.025 14.0 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_11 PF08279.7 AIC15148.1 - 0.014 15.0 0.0 0.034 13.8 0.0 1.7 1 1 0 1 1 1 0 HTH domain FaeA PF04703.7 AIC15148.1 - 0.018 15.2 0.0 0.029 14.5 0.0 1.4 1 0 0 1 1 1 0 FaeA-like protein HTH_Crp_2 PF13545.1 AIC15148.1 - 0.021 14.6 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_23 PF13384.1 AIC15148.1 - 0.029 14.0 0.0 0.051 13.2 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain HTH_29 PF13551.1 AIC15148.1 - 0.033 14.3 0.1 0.057 13.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix HTH_27 PF13463.1 AIC15148.1 - 0.038 14.3 0.0 0.078 13.3 0.0 1.7 1 1 0 1 1 1 0 Winged helix DNA-binding domain MarR PF01047.17 AIC15148.1 - 0.043 13.5 0.0 0.1 12.2 0.0 1.6 2 0 0 2 2 2 0 MarR family LexA_DNA_bind PF01726.11 AIC15148.1 - 0.048 13.2 0.1 0.086 12.4 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain DUF4423 PF14394.1 AIC15148.1 - 0.054 13.0 0.1 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) HTH_AsnC-type PF13404.1 AIC15148.1 - 0.08 12.4 0.1 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain CobN-Mg_chel PF02514.11 AIC15148.1 - 0.13 9.6 0.1 0.14 9.5 0.0 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase TFIIB PF00382.14 AIC15150.1 - 0.13 12.0 1.7 8.1 6.3 0.3 2.6 2 1 0 2 2 2 0 Transcription factor TFIIB repeat ParBc PF02195.13 AIC15151.1 - 4.3e-14 52.3 0.0 8.1e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 ParB-like nuclease domain VirB8 PF04335.8 AIC15152.1 - 0.0089 15.6 1.3 0.0089 15.6 0.9 1.7 1 1 1 2 2 2 1 VirB8 protein Cadherin-like PF12733.2 AIC15152.1 - 0.017 15.3 6.0 0.098 12.9 4.2 2.0 1 1 0 1 1 1 0 Cadherin-like beta sandwich domain DUF1034 PF06280.7 AIC15152.1 - 0.021 15.1 3.5 0.033 14.6 2.4 1.3 1 0 0 1 1 1 0 Fn3-like domain (DUF1034) CBM_4_9 PF02018.12 AIC15152.1 - 0.023 14.7 1.7 1.8 8.5 0.0 2.1 1 1 0 2 2 2 0 Carbohydrate binding domain DUF2393 PF09624.5 AIC15152.1 - 0.034 13.6 4.2 0.055 13.0 2.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2393) Big_2 PF02368.13 AIC15152.1 - 0.13 12.1 0.5 0.13 12.1 0.3 2.4 1 1 0 2 2 2 0 Bacterial Ig-like domain (group 2) CARDB PF07705.6 AIC15152.1 - 0.19 11.7 3.0 0.43 10.6 2.1 1.7 1 1 0 1 1 1 0 CARDB DUF1628 PF07790.6 AIC15152.1 - 0.64 10.8 6.7 0.56 10.9 3.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1628) DUF1628 PF07790.6 AIC15153.1 - 0.007 17.1 1.0 0.012 16.3 0.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1628) I-set PF07679.11 AIC15154.1 - 3.3e-05 23.6 3.0 5.4 6.9 0.0 7.8 9 0 0 9 9 9 1 Immunoglobulin I-set domain A2M_N PF01835.14 AIC15154.1 - 7.5e-05 22.9 13.8 14 6.0 0.0 8.1 8 1 1 9 9 9 1 MG2 domain CopC PF04234.7 AIC15154.1 - 0.00028 21.4 10.3 2.3 8.8 0.1 7.3 7 1 0 7 7 7 1 CopC domain DUF4625 PF15418.1 AIC15154.1 - 0.00066 19.8 0.0 19 5.3 0.0 5.6 6 0 0 6 6 6 0 Domain of unknown function (DUF4625) A2M_N_2 PF07703.9 AIC15154.1 - 0.011 15.5 8.6 1.6 8.5 0.0 5.4 4 1 0 4 4 4 0 Alpha-2-macroglobulin family N-terminal region Y_Y_Y PF07495.8 AIC15154.1 - 0.064 13.0 10.8 0.78 9.5 0.0 7.1 9 1 0 9 9 9 0 Y_Y_Y domain Cadherin PF00028.12 AIC15154.1 - 6.7 7.0 17.6 77 3.6 0.2 7.4 8 0 0 8 8 8 0 Cadherin domain NPCBM_assoc PF10633.4 AIC15154.1 - 7.7 6.6 53.5 1.4 8.9 1.5 11.2 10 1 0 11 11 11 0 NPCBM-associated, NEW3 domain of alpha-galactosidase E1_DerP2_DerF2 PF02221.10 AIC15154.1 - 8.8 6.5 8.5 1.9e+02 2.2 0.0 5.7 4 2 2 6 6 6 0 ML domain HATPase_c_3 PF13589.1 AIC15157.1 - 9.1e-08 31.8 0.0 2.2e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase T2SE PF00437.15 AIC15158.1 - 1.9e-40 138.4 0.0 3e-40 137.8 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_18 PF13238.1 AIC15158.1 - 0.0012 19.2 0.1 0.012 15.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.22 AIC15158.1 - 0.0017 18.6 0.0 0.0081 16.4 0.0 2.1 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.1 AIC15158.1 - 0.0061 16.0 0.4 0.018 14.5 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.13 AIC15158.1 - 0.016 14.7 0.2 0.045 13.2 0.1 1.7 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_30 PF13604.1 AIC15158.1 - 0.034 13.7 0.1 0.23 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.1 AIC15158.1 - 0.058 13.5 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.17 AIC15158.1 - 0.061 12.7 0.2 0.14 11.5 0.1 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_28 PF13521.1 AIC15158.1 - 0.075 12.9 0.7 0.23 11.3 0.0 2.1 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.4 AIC15158.1 - 0.084 11.4 0.1 0.17 10.5 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_10 PF12846.2 AIC15158.1 - 0.096 12.1 1.6 0.2 11.0 1.1 1.5 1 0 0 1 1 1 0 AAA-like domain MobB PF03205.9 AIC15158.1 - 0.13 11.9 0.0 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 AIC15158.1 - 0.14 11.5 0.1 0.29 10.5 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain HAUS4 PF14735.1 AIC15158.1 - 0.14 11.3 0.1 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 4 DUF2499 PF10693.4 AIC15160.1 - 0.076 13.0 0.8 0.1 12.6 0.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2499) T2SF PF00482.18 AIC15161.1 - 2.3e-06 27.5 0.1 2.3e-06 27.5 0.0 3.9 4 0 0 4 4 4 2 Type II secretion system (T2SS), protein F GRAM PF02893.15 AIC15163.1 - 0.00082 18.8 0.0 0.0018 17.7 0.0 1.5 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.3 AIC15163.1 - 0.0021 17.8 0.1 0.0053 16.5 0.0 1.7 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 PIN PF01850.16 AIC15164.1 - 3.4e-17 62.9 0.1 3.8e-17 62.7 0.1 1.0 1 0 0 1 1 1 1 PIN domain PIN_3 PF13470.1 AIC15164.1 - 0.05 14.2 0.0 0.067 13.8 0.0 1.2 1 0 0 1 1 1 0 PIN domain Antitoxin-MazE PF04014.13 AIC15165.1 - 0.00044 19.8 0.0 0.00089 18.9 0.0 1.7 1 1 0 1 1 1 1 Antidote-toxin recognition MazE DUF123 PF01986.11 AIC15166.1 - 3.2e-17 62.4 0.2 3.7e-17 62.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF123 GIY-YIG PF01541.19 AIC15166.1 - 0.018 15.4 0.0 0.018 15.3 0.0 1.3 1 0 0 1 1 1 0 GIY-YIG catalytic domain PrgI PF12666.2 AIC15167.1 - 0.002 18.2 1.0 0.0031 17.6 0.7 1.2 1 0 0 1 1 1 1 PrgI family protein Big_1 PF02369.11 AIC15167.1 - 0.016 15.1 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 1) DUF2635 PF10948.3 AIC15167.1 - 0.034 13.4 0.1 0.094 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2635) PEGA PF08308.6 AIC15167.1 - 0.049 13.4 0.0 0.16 11.7 0.0 1.8 1 1 0 1 1 1 0 PEGA domain DUF3955 PF13127.1 AIC15167.1 - 2 8.0 6.7 17 5.0 0.1 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3955) AAA_10 PF12846.2 AIC15168.1 - 1e-36 126.9 0.1 5.2e-23 81.9 0.0 2.3 1 1 1 2 2 2 2 AAA-like domain DUF87 PF01935.12 AIC15168.1 - 3.3e-10 40.1 0.0 8e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF87 AAA_22 PF13401.1 AIC15168.1 - 0.0054 16.8 0.0 0.14 12.2 0.0 3.1 3 1 0 3 3 3 1 AAA domain TrwB_AAD_bind PF10412.4 AIC15168.1 - 0.0054 15.3 0.0 2.6 6.5 0.0 2.3 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain TraG-D_C PF12696.2 AIC15168.1 - 0.03 14.1 0.0 0.062 13.1 0.0 1.5 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG DUF3508 PF12018.3 AIC15168.1 - 0.076 11.9 0.6 0.19 10.7 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) FtsK_SpoIIIE PF01580.13 AIC15168.1 - 0.12 11.8 0.0 0.4 10.1 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family GtrA PF04138.9 AIC15169.1 - 0.023 14.6 0.1 0.037 13.9 0.0 1.4 1 1 0 1 1 1 0 GtrA-like protein DUF418 PF04235.7 AIC15169.1 - 0.024 14.2 0.9 0.039 13.6 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF418) EmrE PF13536.1 AIC15169.1 - 0.089 12.9 2.7 0.16 12.1 1.8 1.5 1 1 0 1 1 1 0 Multidrug resistance efflux transporter MadM PF03818.8 AIC15169.1 - 0.3 10.6 4.0 4.9 6.7 0.0 2.8 3 0 0 3 3 3 0 Malonate/sodium symporter MadM subunit Rab5ip PF07019.7 AIC15169.1 - 0.51 10.4 3.1 1.1 9.4 0.1 2.1 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) Yip1 PF04893.12 AIC15169.1 - 1.7 8.0 10.3 15 4.9 7.1 1.9 1 1 0 1 1 1 0 Yip1 domain TrbC PF04956.8 AIC15169.1 - 6 6.9 6.8 3.7 7.6 0.1 2.7 2 1 0 2 2 2 0 TrbC/VIRB2 family AAA_10 PF12846.2 AIC15172.1 - 3.3e-19 69.4 0.3 1e-18 67.8 0.1 1.8 2 0 0 2 2 2 1 AAA-like domain FtsK_SpoIIIE PF01580.13 AIC15172.1 - 1.3e-06 27.9 0.2 6.3e-06 25.8 0.0 2.1 2 1 0 2 2 2 1 FtsK/SpoIIIE family MarR_2 PF12802.2 AIC15172.1 - 3.7e-06 26.4 0.3 0.00024 20.7 0.0 2.5 2 0 0 2 2 2 1 MarR family AAA_22 PF13401.1 AIC15172.1 - 6.5e-05 23.0 0.1 0.0096 16.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain TrwB_AAD_bind PF10412.4 AIC15172.1 - 0.00012 20.7 0.0 0.0008 18.1 0.0 2.1 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain Arch_ATPase PF01637.13 AIC15172.1 - 0.00058 19.6 1.3 0.092 12.4 0.0 3.0 4 0 0 4 4 4 1 Archaeal ATPase AAA_14 PF13173.1 AIC15172.1 - 0.00075 19.3 0.1 0.013 15.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain HTH_45 PF14947.1 AIC15172.1 - 0.00081 19.1 0.0 0.0084 15.8 0.0 2.4 2 0 0 2 2 2 1 Winged helix-turn-helix Miro PF08477.8 AIC15172.1 - 0.0049 17.3 0.1 0.042 14.3 0.0 2.4 2 0 0 2 2 2 1 Miro-like protein DUF87 PF01935.12 AIC15172.1 - 0.029 14.2 0.2 0.26 11.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function DUF87 HTH_24 PF13412.1 AIC15172.1 - 0.05 12.9 3.3 0.17 11.2 0.0 3.2 4 0 0 4 4 4 0 Winged helix-turn-helix DNA-binding ATP-synt_ab PF00006.20 AIC15172.1 - 0.069 12.6 0.0 0.083 12.3 0.0 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain HTH_IclR PF09339.5 AIC15172.1 - 0.079 12.5 1.3 0.65 9.6 0.0 2.9 4 0 0 4 4 3 0 IclR helix-turn-helix domain MMR_HSR1 PF01926.18 AIC15172.1 - 0.085 12.8 0.9 0.26 11.2 0.0 2.3 3 0 0 3 3 3 0 50S ribosome-binding GTPase MarR PF01047.17 AIC15172.1 - 0.088 12.5 0.0 0.32 10.7 0.0 1.9 1 0 0 1 1 1 0 MarR family SnoaL PF07366.7 AIC15175.1 - 0.014 14.9 0.0 0.02 14.4 0.0 1.3 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase PapC_N PF13954.1 AIC15175.1 - 0.046 13.3 1.1 0.39 10.2 0.0 2.0 1 1 1 2 2 2 0 PapC N-terminal domain zf-C3HC4_3 PF13920.1 AIC15177.1 - 0.061 12.9 0.2 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Vps39_2 PF10367.4 AIC15177.1 - 0.075 13.2 0.2 0.1 12.7 0.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 RNA_pol_Rpc34 PF05158.7 AIC15179.1 - 0.041 13.0 0.0 0.042 13.0 0.0 1.0 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit HATPase_c PF02518.21 AIC15180.1 - 0.0015 18.2 0.1 0.0083 15.8 0.0 2.4 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_S7 PF00177.16 AIC15183.1 - 0.081 12.5 0.4 0.087 12.4 0.3 1.1 1 0 0 1 1 1 0 Ribosomal protein S7p/S5e TRAM PF01938.15 AIC15184.1 - 2.3e-14 52.9 2.0 2.7e-14 52.6 1.4 1.1 1 0 0 1 1 1 1 TRAM domain FKBP_C PF00254.23 AIC15184.1 - 0.086 12.8 0.2 0.15 12.1 0.1 1.4 1 1 0 1 1 1 0 FKBP-type peptidyl-prolyl cis-trans isomerase EIF_2_alpha PF07541.7 AIC15184.1 - 0.11 12.2 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit GAS PF13851.1 AIC15186.1 - 0.0087 15.2 1.2 0.47 9.6 0.0 2.1 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding K-box PF01486.12 AIC15186.1 - 0.021 14.6 2.8 0.2 11.4 0.1 2.2 2 0 0 2 2 2 0 K-box region DUF2681 PF10883.3 AIC15186.1 - 0.061 13.5 1.4 3.5 7.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Cep57_MT_bd PF06657.8 AIC15186.1 - 0.086 12.7 0.4 1.1 9.2 0.1 2.2 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Snapin_Pallidin PF14712.1 AIC15186.1 - 0.099 12.9 4.2 2 8.7 0.2 2.1 2 0 0 2 2 2 0 Snapin/Pallidin Peptidase_A24 PF01478.13 AIC15187.1 - 1.1e-10 41.5 10.2 1.1e-10 41.5 7.1 2.2 2 0 0 2 2 2 1 Type IV leader peptidase family Arc_PepC_II PF06847.6 AIC15187.1 - 1.2e-08 35.3 0.0 2e-08 34.5 0.0 1.4 1 0 0 1 1 1 1 Archaeal Peptidase A24 C-terminus Type II CbiN PF02553.10 AIC15187.1 - 0.065 13.2 0.2 0.2 11.6 0.1 1.9 1 1 0 1 1 1 0 Cobalt transport protein component CbiN RHH_1 PF01402.16 AIC15188.1 - 0.0011 18.7 0.0 0.018 14.9 0.0 2.1 1 1 1 2 2 2 1 Ribbon-helix-helix protein, copG family RHH_2 PF03693.9 AIC15188.1 - 0.0043 17.2 0.0 0.0056 16.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0156) PRD PF00874.15 AIC15188.1 - 0.15 12.2 1.8 0.37 10.9 1.2 1.7 1 1 0 1 1 1 0 PRD domain TcdB_N PF12918.2 AIC15191.1 - 0.017 15.1 1.1 0.036 14.1 0.2 1.7 1 1 1 2 2 2 0 TcdB toxin N-terminal helical domain Hrs_helical PF12210.3 AIC15191.1 - 0.019 15.2 0.9 0.022 14.9 0.6 1.0 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate KNOX2 PF03791.8 AIC15191.1 - 0.13 11.5 0.5 0.15 11.3 0.4 1.2 1 0 0 1 1 1 0 KNOX2 domain IFT20 PF14931.1 AIC15191.1 - 0.47 10.3 4.7 0.45 10.4 3.2 1.0 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 Phage_integrase PF00589.17 AIC15192.1 - 3.7e-15 56.0 0.0 7e-15 55.1 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family zf-ribbon_3 PF13248.1 AIC15192.1 - 3.1e-05 23.0 1.2 5e-05 22.3 0.8 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 AIC15192.1 - 0.0053 16.5 2.1 0.012 15.4 0.4 2.0 2 0 0 2 2 2 1 Double zinc ribbon Ribosomal_L37e PF01907.14 AIC15192.1 - 0.016 14.9 1.0 0.039 13.7 0.7 1.6 1 0 0 1 1 1 0 Ribosomal protein L37e Phage_int_SAM_1 PF02899.12 AIC15192.1 - 0.031 14.4 0.1 0.18 11.9 0.0 2.3 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain TF_Zn_Ribbon PF08271.7 AIC15192.1 - 0.1 11.9 2.5 0.37 10.1 1.7 2.0 1 1 0 1 1 1 0 TFIIB zinc-binding YhfH PF14149.1 AIC15192.1 - 0.15 11.8 8.4 0.16 11.7 0.2 3.0 2 1 1 3 3 3 0 YhfH-like protein zinc_ribbon_2 PF13240.1 AIC15192.1 - 0.41 10.1 6.5 1.5 8.3 4.5 1.9 1 1 0 1 1 1 0 zinc-ribbon domain UPF0547 PF10571.4 AIC15192.1 - 0.43 10.3 6.0 1.6 8.4 4.2 2.0 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-tcix PF14952.1 AIC15192.1 - 3 7.2 10.0 62 3.0 1.7 2.5 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding DUF1059 PF06348.6 AIC15193.1 - 5.6e-20 70.9 0.9 6.6e-20 70.6 0.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) GST_C_2 PF13410.1 AIC15200.1 - 0.0034 17.2 0.2 0.016 15.0 0.2 2.2 1 1 1 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.20 AIC15200.1 - 0.0049 16.8 0.0 0.01 15.8 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain PAC2 PF09754.4 AIC15201.1 - 1.4e-44 152.6 0.0 1.6e-44 152.3 0.0 1.0 1 0 0 1 1 1 1 PAC2 family tRNA_anti-codon PF01336.20 AIC15202.1 - 1e-08 34.9 0.2 1.2e-08 34.6 0.2 1.1 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4397 PF14344.1 AIC15202.1 - 0.11 12.8 0.0 0.13 12.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4397) zf-CHY PF05495.7 AIC15203.1 - 0.0083 16.2 1.5 0.0094 16.0 1.0 1.1 1 0 0 1 1 1 1 CHY zinc finger zf-UBR PF02207.15 AIC15203.1 - 0.0091 15.6 0.7 0.0094 15.6 0.5 1.1 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Cytochrome_C7 PF14522.1 AIC15203.1 - 0.019 14.6 1.2 0.023 14.3 0.9 1.2 1 0 0 1 1 1 0 Cytochrome c7 A2L_zn_ribbon PF08792.5 AIC15203.1 - 0.021 14.2 3.1 0.38 10.2 0.3 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain TF_Zn_Ribbon PF08271.7 AIC15203.1 - 0.024 13.9 1.3 0.036 13.3 0.9 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding DZR PF12773.2 AIC15203.1 - 0.045 13.5 0.9 0.071 12.9 0.6 1.3 1 1 0 1 1 1 0 Double zinc ribbon GATA PF00320.22 AIC15203.1 - 0.051 12.9 0.2 0.089 12.1 0.1 1.4 1 1 0 1 1 1 0 GATA zinc finger Paired_CXXCH_1 PF09699.5 AIC15203.1 - 0.15 11.5 0.5 0.15 11.5 0.3 2.0 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) DUF2082 PF09855.4 AIC15203.1 - 0.21 11.4 3.1 4.2 7.3 0.2 2.1 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zinc_ribbon_4 PF13717.1 AIC15203.1 - 0.25 11.0 2.6 0.79 9.4 1.8 1.8 1 1 0 1 1 1 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.8 AIC15203.1 - 0.3 10.5 3.0 2.6 7.5 2.1 2.0 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_5 PF13719.1 AIC15203.1 - 0.31 10.6 2.8 0.9 9.1 2.0 1.8 1 1 0 1 1 1 0 zinc-ribbon domain zf-trcl PF13451.1 AIC15203.1 - 0.4 10.3 2.3 0.87 9.2 0.2 2.0 2 0 0 2 2 2 0 Probable zinc-binding domain Cytochrom_NNT PF03264.9 AIC15203.1 - 0.45 9.9 4.6 1.1 8.6 3.2 1.7 1 1 0 1 1 1 0 NapC/NirT cytochrome c family, N-terminal region Lar_restr_allev PF14354.1 AIC15203.1 - 0.49 10.7 2.2 0.94 9.8 1.5 1.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.2 AIC15203.1 - 0.57 10.0 2.2 13 5.6 0.1 2.0 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DUF2387 PF09526.5 AIC15203.1 - 0.76 9.7 3.7 19 5.2 3.0 2.0 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) DUF192 PF02643.10 AIC15204.1 - 3.4e-17 62.0 0.0 4.2e-17 61.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 Arch_flagellin PF01917.11 AIC15205.1 - 1.4e-19 70.4 8.6 1.9e-19 70.0 5.9 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin Bundlin PF05307.6 AIC15205.1 - 0.055 13.3 0.4 0.055 13.3 0.3 2.3 2 1 0 2 2 2 0 Bundlin TrmB PF01978.14 AIC15206.1 - 1.3e-11 44.0 0.0 3.4e-11 42.6 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.3 AIC15206.1 - 2.6e-10 39.6 0.1 0.0001 21.4 0.0 2.3 2 0 0 2 2 2 2 Archaeal transcriptional regulator TrmB MarR_2 PF12802.2 AIC15206.1 - 0.0045 16.6 0.1 0.013 15.1 0.1 1.8 1 0 0 1 1 1 1 MarR family MarR PF01047.17 AIC15206.1 - 0.0047 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 MarR family PLDc_2 PF13091.1 AIC15206.1 - 0.0077 15.9 0.0 0.082 12.6 0.0 2.6 2 1 0 2 2 2 1 PLD-like domain HTH_IclR PF09339.5 AIC15206.1 - 0.069 12.7 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain MCPsignal PF00015.16 AIC15207.1 - 9.4e-52 175.6 61.8 5.4e-49 166.6 26.4 3.3 3 1 0 3 3 3 2 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.20 AIC15207.1 - 9.3e-17 60.9 5.0 5.9e-15 55.2 0.0 4.4 4 1 1 5 5 5 1 HAMP domain Isochorismatase PF00857.15 AIC15207.1 - 0.0029 17.5 1.6 2.4 8.0 0.0 3.1 3 0 0 3 3 3 2 Isochorismatase family Laminin_II PF06009.7 AIC15207.1 - 4.8 6.9 44.1 0.41 10.4 2.6 5.9 3 2 3 6 6 6 0 Laminin Domain II DUF3989 PF13150.1 AIC15209.1 - 0.029 13.8 0.1 0.04 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) MCPsignal PF00015.16 AIC15210.1 - 1e-13 51.3 2.8 1.6e-13 50.6 2.0 1.3 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Cache_1 PF02743.13 AIC15210.1 - 0.0029 17.1 0.0 0.012 15.1 0.0 2.0 2 0 0 2 2 2 1 Cache domain CheW PF01584.14 AIC15211.1 - 5.9e-31 106.7 1.9 7e-31 106.5 1.3 1.0 1 0 0 1 1 1 1 CheW-like domain Response_reg PF00072.19 AIC15212.1 - 1.8e-30 105.2 1.2 2e-30 105.0 0.9 1.0 1 0 0 1 1 1 1 Response regulator receiver domain DUF3798 PF12683.2 AIC15212.1 - 0.0025 16.9 0.4 0.0034 16.5 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) CheB_methylest PF01339.12 AIC15213.1 - 1.5e-61 207.0 0.7 4.4e-61 205.4 0.4 1.8 2 0 0 2 2 2 1 CheB methylesterase Response_reg PF00072.19 AIC15213.1 - 3.1e-21 75.4 0.1 6.5e-21 74.4 0.0 1.6 1 0 0 1 1 1 1 Response regulator receiver domain DUF3798 PF12683.2 AIC15213.1 - 6.6e-05 22.1 0.0 0.00011 21.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) Hpt PF01627.18 AIC15214.1 - 5e-22 77.7 0.6 1.4e-21 76.2 0.4 1.8 1 0 0 1 1 1 1 Hpt domain HATPase_c PF02518.21 AIC15214.1 - 4.5e-21 74.6 1.8 1.5e-20 72.9 0.7 2.2 1 1 1 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase CheW PF01584.14 AIC15214.1 - 1.6e-20 72.9 0.3 2.9e-20 72.1 0.2 1.5 1 0 0 1 1 1 1 CheW-like domain H-kinase_dim PF02895.9 AIC15214.1 - 2.1e-12 47.2 1.3 2.1e-12 47.2 0.9 2.8 3 0 0 3 3 3 1 Signal transducing histidine kinase, homodimeric domain Snf7 PF03357.16 AIC15214.1 - 0.001 18.4 3.4 0.001 18.4 2.3 2.4 3 1 0 3 3 3 1 Snf7 HATPase_c_3 PF13589.1 AIC15214.1 - 0.015 14.9 1.3 0.059 13.0 0.9 2.0 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RasGAP_C PF03836.10 AIC15214.1 - 0.2 11.3 6.2 1.9 8.1 0.2 3.5 3 1 0 3 3 3 0 RasGAP C-terminus MRP-S31 PF15433.1 AIC15214.1 - 0.24 10.8 5.1 0.87 8.9 2.7 2.1 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 Blo-t-5 PF11642.3 AIC15214.1 - 5 6.9 9.7 0.98 9.1 0.8 3.5 3 1 1 4 4 4 0 Mite allergen Blo t 5 CheC PF04509.7 AIC15215.1 - 3.6e-09 36.1 0.1 8.6e-09 34.9 0.1 1.7 1 0 0 1 1 1 1 CheC-like family CheX PF13690.1 AIC15215.1 - 0.00037 20.2 0.0 0.0012 18.6 0.0 1.8 2 0 0 2 2 2 1 Chemotaxis phosphatase CheX Chlorosome_CsmC PF11098.3 AIC15215.1 - 0.12 12.0 0.1 0.18 11.5 0.1 1.3 1 0 0 1 1 1 0 Chlorosome envelope protein C CheD PF03975.8 AIC15216.1 - 1.2e-27 95.8 0.5 1.5e-27 95.6 0.3 1.1 1 0 0 1 1 1 1 CheD chemotactic sensory transduction Cu-oxidase_4 PF02578.10 AIC15216.1 - 0.087 11.8 0.1 0.17 10.9 0.1 1.4 1 0 0 1 1 1 0 Multi-copper polyphenol oxidoreductase laccase CheR PF01739.13 AIC15217.1 - 8.6e-57 191.6 0.0 1e-56 191.3 0.0 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.10 AIC15217.1 - 1.3e-11 43.6 0.9 3e-11 42.5 0.6 1.6 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_12 PF08242.7 AIC15217.1 - 5.9e-08 33.1 0.0 1.8e-07 31.5 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15217.1 - 1.6e-07 30.9 0.1 0.017 14.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15217.1 - 1.8e-07 31.7 0.0 3.2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC15217.1 - 4.3e-06 27.1 0.0 4.8e-05 23.7 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15217.1 - 1.7e-05 25.1 0.0 6.4e-05 23.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15217.1 - 2.2e-05 24.2 0.0 3.2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 AIC15217.1 - 0.00048 19.4 0.0 0.00077 18.7 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase NodS PF05401.6 AIC15217.1 - 0.032 13.6 0.1 0.099 12.0 0.0 1.7 1 1 1 2 2 2 0 Nodulation protein S (NodS) TehB PF03848.9 AIC15217.1 - 0.077 12.1 0.0 0.38 9.9 0.0 1.9 2 0 0 2 2 2 0 Tellurite resistance protein TehB T2SE PF00437.15 AIC15218.1 - 3.5e-44 150.7 0.0 5e-44 150.2 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.1 AIC15218.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain TrmB PF01978.14 AIC15219.1 - 2.6e-13 49.4 0.4 1.7e-12 46.8 0.1 2.4 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.15 AIC15219.1 - 0.031 13.9 0.0 0.063 12.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family MarR_2 PF12802.2 AIC15219.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_IclR PF09339.5 AIC15219.1 - 0.13 11.9 0.8 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 IclR helix-turn-helix domain Arch_flagellin PF01917.11 AIC15220.1 - 4.1e-24 85.2 11.6 6.5e-24 84.6 8.0 1.3 1 1 0 1 1 1 1 Archaebacterial flagellin EIID-AGA PF03613.9 AIC15220.1 - 0.064 12.1 0.5 0.085 11.7 0.4 1.2 1 0 0 1 1 1 0 PTS system mannose/fructose/sorbose family IID component Rab5ip PF07019.7 AIC15220.1 - 0.073 13.2 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 Rab5-interacting protein (Rab5ip) Arch_flagellin PF01917.11 AIC15221.1 - 3.1e-20 72.6 15.5 4.2e-20 72.1 10.7 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin DUF2393 PF09624.5 AIC15221.1 - 0.14 11.6 1.1 0.22 11.0 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) Reo_sigmaC PF04582.7 AIC15222.1 - 0.032 13.4 0.0 0.051 12.7 0.0 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein FlaC_arch PF05377.6 AIC15222.1 - 0.055 13.3 1.3 0.15 12.0 0.7 1.9 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) Cluap1 PF10234.4 AIC15222.1 - 0.098 11.8 0.1 0.15 11.2 0.1 1.2 1 0 0 1 1 1 0 Clusterin-associated protein-1 Arch_flagellin PF01917.11 AIC15223.1 - 5.3e-08 32.6 9.1 5.7e-07 29.3 6.3 2.0 1 1 0 1 1 1 1 Archaebacterial flagellin DUF973 PF06157.6 AIC15223.1 - 0.087 11.7 1.5 0.21 10.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF973) KaiC PF06745.8 AIC15225.1 - 2e-21 76.1 0.2 2.3e-21 75.9 0.1 1.0 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 AIC15225.1 - 2.3e-09 36.9 0.0 3.2e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain DUF835 PF05763.7 AIC15225.1 - 0.00058 19.4 0.2 0.0014 18.1 0.2 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF835) Rad51 PF08423.6 AIC15225.1 - 0.00066 18.6 0.0 0.00094 18.1 0.0 1.2 1 0 0 1 1 1 1 Rad51 Arch_ATPase PF01637.13 AIC15225.1 - 0.001 18.8 0.3 0.0022 17.7 0.2 1.5 1 1 0 1 1 1 1 Archaeal ATPase AAA_16 PF13191.1 AIC15225.1 - 0.0037 17.2 0.0 0.005 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain PAXNEB PF05625.6 AIC15225.1 - 0.0054 15.6 0.7 0.016 14.1 0.0 1.9 2 0 0 2 2 2 1 PAXNEB protein RAP1 PF07218.6 AIC15225.1 - 0.006 14.7 0.1 0.0068 14.5 0.1 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) DUF2348 PF09807.4 AIC15225.1 - 0.0082 15.2 1.7 0.2 10.7 0.3 2.1 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2348) ABC_tran PF00005.22 AIC15225.1 - 0.0092 16.2 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.1 AIC15225.1 - 0.0096 16.2 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 AIC15225.1 - 0.011 15.3 0.1 0.027 14.1 0.0 1.6 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.1 AIC15225.1 - 0.012 15.5 0.2 0.03 14.2 0.1 1.7 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.8 AIC15225.1 - 0.02 13.8 0.0 0.035 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) GvpD PF07088.6 AIC15225.1 - 0.022 13.1 0.0 0.026 12.8 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein Ras PF00071.17 AIC15225.1 - 0.041 13.2 0.0 0.083 12.2 0.0 1.5 1 0 0 1 1 1 0 Ras family Miro PF08477.8 AIC15225.1 - 0.044 14.2 0.0 0.069 13.6 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein IstB_IS21 PF01695.12 AIC15225.1 - 0.055 12.8 0.0 0.38 10.1 0.0 2.1 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.17 AIC15225.1 - 0.063 13.4 0.1 0.16 12.1 0.0 1.7 2 0 0 2 2 2 0 RNA helicase Elong_Iki1 PF10483.4 AIC15225.1 - 0.068 12.5 0.1 0.09 12.1 0.0 1.2 1 0 0 1 1 1 0 Elongator subunit Iki1 MinE PF03776.9 AIC15225.1 - 0.069 12.6 0.3 0.45 10.0 0.0 2.2 2 0 0 2 2 2 0 Septum formation topological specificity factor MinE AAA_24 PF13479.1 AIC15225.1 - 0.07 12.6 0.0 0.15 11.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 AIC15225.1 - 0.088 11.7 0.1 0.12 11.2 0.1 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.21 AIC15225.1 - 0.092 12.2 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain UPF0079 PF02367.12 AIC15225.1 - 0.1 12.2 0.0 0.27 10.8 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 AAA_22 PF13401.1 AIC15225.1 - 0.14 12.2 0.1 0.21 11.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain T2SF PF00482.18 AIC15226.1 - 1.9e-08 34.2 11.5 1.3e-06 28.3 0.4 3.5 3 0 0 3 3 3 2 Type II secretion system (T2SS), protein F DUF3227 PF11537.3 AIC15227.1 - 0.001 19.1 0.0 0.0012 18.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3227) KaiC PF06745.8 AIC15229.1 - 8.5e-53 178.7 0.3 1.3e-52 178.1 0.2 1.3 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.1 AIC15229.1 - 4.5e-11 42.5 0.0 7e-11 41.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 AIC15229.1 - 1.4e-05 24.3 0.0 1.9e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_14 PF13173.1 AIC15229.1 - 2.5e-05 24.2 0.2 0.00015 21.6 0.1 2.1 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 AIC15229.1 - 2.9e-05 23.5 0.1 0.00027 20.4 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein DUF2075 PF09848.4 AIC15229.1 - 0.00016 20.7 0.0 0.00021 20.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) DnaB_C PF03796.10 AIC15229.1 - 0.00055 18.9 0.0 0.0012 17.7 0.0 1.5 1 1 1 2 2 2 1 DnaB-like helicase C terminal domain AAA_19 PF13245.1 AIC15229.1 - 0.0022 17.7 0.0 0.0059 16.3 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain GvpD PF07088.6 AIC15229.1 - 0.0024 16.2 0.8 0.013 13.8 0.6 1.9 1 1 0 1 1 1 1 GvpD gas vesicle protein PhoH PF02562.11 AIC15229.1 - 0.0026 17.0 0.7 0.02 14.1 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.1 AIC15229.1 - 0.0034 17.5 0.1 0.0069 16.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.12 AIC15229.1 - 0.0037 16.1 0.2 0.017 13.9 0.1 1.8 1 1 1 2 2 2 1 Parvovirus non-structural protein NS1 Arch_ATPase PF01637.13 AIC15229.1 - 0.0053 16.4 0.1 0.0085 15.8 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase Elong_Iki1 PF10483.4 AIC15229.1 - 0.015 14.7 0.0 0.018 14.4 0.0 1.1 1 0 0 1 1 1 0 Elongator subunit Iki1 TIP49 PF06068.8 AIC15229.1 - 0.015 14.0 0.1 0.033 12.8 0.0 1.5 1 0 0 1 1 1 0 TIP49 C-terminus Rad51 PF08423.6 AIC15229.1 - 0.017 14.0 0.3 0.042 12.7 0.1 1.7 2 1 0 2 2 2 0 Rad51 NACHT PF05729.7 AIC15229.1 - 0.018 14.7 0.0 0.044 13.4 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.1 AIC15229.1 - 0.018 15.3 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain DEAD PF00270.24 AIC15229.1 - 0.036 13.5 0.1 0.062 12.7 0.0 1.4 1 1 0 1 1 1 0 DEAD/DEAH box helicase PAXNEB PF05625.6 AIC15229.1 - 0.046 12.5 0.9 0.48 9.2 0.1 2.0 1 1 1 2 2 2 0 PAXNEB protein AAA_16 PF13191.1 AIC15229.1 - 0.048 13.6 0.1 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.1 AIC15229.1 - 0.085 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 AIC15229.1 - 0.099 12.1 0.1 0.17 11.3 0.0 1.3 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_17 PF13207.1 AIC15229.1 - 0.12 13.2 0.4 0.26 12.1 0.3 1.8 1 1 0 1 1 1 0 AAA domain PIF1 PF05970.9 AIC15229.1 - 0.37 9.6 2.5 2.3 7.0 0.1 2.1 1 1 1 2 2 2 0 PIF1-like helicase DUF1686 PF07937.6 AIC15230.1 - 0.12 11.9 3.7 0.2 11.2 0.9 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1686) TrmB PF01978.14 AIC15232.1 - 6.8e-14 51.3 0.2 1.6e-13 50.1 0.1 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB FUR PF01475.14 AIC15232.1 - 0.072 13.0 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Ferric uptake regulator family MotA_activ PF09114.5 AIC15232.1 - 0.1 12.3 0.3 0.3 10.8 0.0 1.9 2 0 0 2 2 2 0 Transcription factor MotA, activation domain Arc_PepC_II PF06847.6 AIC15234.1 - 1.4e-07 31.8 0.0 2.1e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 Archaeal Peptidase A24 C-terminus Type II Peptidase_A24 PF01478.13 AIC15234.1 - 4.4e-06 26.8 7.4 4.4e-06 26.8 5.2 2.2 2 0 0 2 2 2 1 Type IV leader peptidase family GFO_IDH_MocA PF01408.17 AIC15235.1 - 1.7e-27 96.3 0.0 3.1e-27 95.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.12 AIC15235.1 - 2.8e-08 33.5 0.0 8.7e-08 31.9 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain Shikimate_DH PF01488.15 AIC15235.1 - 1.3e-05 25.3 0.1 2.9e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Semialdhyde_dh PF01118.19 AIC15235.1 - 0.00045 20.5 0.0 0.00095 19.4 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 AIC15235.1 - 0.0021 17.2 0.0 0.004 16.3 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 AIC15235.1 - 0.0025 17.1 0.0 0.0047 16.3 0.0 1.4 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain AlaDh_PNT_C PF01262.16 AIC15235.1 - 0.026 14.0 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_2 PF03446.10 AIC15235.1 - 0.047 13.5 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase Pyridox_oxidase PF01243.15 AIC15237.1 - 5.3e-15 55.1 0.0 8.6e-15 54.5 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 AIC15237.1 - 1.6e-09 37.7 0.0 2.2e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase AMP-binding PF00501.23 AIC15238.1 - 5.1e-97 324.9 0.1 6.3e-97 324.6 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 AIC15238.1 - 6.2e-20 71.9 1.3 2.7e-19 69.8 0.2 2.3 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain MethyltransfD12 PF02086.10 AIC15239.1 - 1.3e-45 155.8 0.0 1.5e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Methyltransf_26 PF13659.1 AIC15239.1 - 0.0076 16.2 4.2 0.017 15.1 2.9 1.6 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.10 AIC15239.1 - 0.016 14.6 0.2 4.9 6.4 0.1 2.8 2 1 1 3 3 3 0 Conserved hypothetical protein 95 CBFD_NFYB_HMF PF00808.18 AIC15241.1 - 2.8e-17 62.5 0.3 3.1e-17 62.4 0.2 1.0 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.19 AIC15241.1 - 7.1e-12 45.2 0.6 8.3e-12 45.0 0.4 1.1 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-S PF15630.1 AIC15241.1 - 4e-05 23.7 0.1 4.3e-05 23.6 0.1 1.1 1 0 0 1 1 1 1 Kinetochore component CENP-S TFIID-31kDa PF02291.10 AIC15241.1 - 0.00096 18.9 0.0 0.0011 18.7 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TAF PF02969.12 AIC15241.1 - 0.002 18.0 0.5 0.0024 17.7 0.3 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Bromo_TP PF07524.8 AIC15241.1 - 0.0021 17.7 0.0 0.0023 17.5 0.0 1.0 1 0 0 1 1 1 1 Bromodomain associated CENP-T PF15511.1 AIC15241.1 - 0.0042 16.4 0.2 0.0045 16.3 0.1 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T TFIIB PF00382.14 AIC15241.1 - 0.042 13.6 0.2 0.065 13.0 0.1 1.3 1 0 0 1 1 1 0 Transcription factor TFIIB repeat TFIID-18kDa PF02269.11 AIC15241.1 - 0.065 13.0 0.0 0.07 12.9 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit HK97-gp10_like PF04883.7 AIC15241.1 - 0.11 13.4 0.4 0.13 13.1 0.3 1.3 1 0 0 1 1 1 0 Bacteriophage HK97-gp10, putative tail-component TFIID_20kDa PF03847.8 AIC15241.1 - 0.13 12.5 0.1 0.14 12.4 0.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID subunit A TatD_DNase PF01026.16 AIC15242.1 - 1.2e-41 142.5 0.0 1.5e-41 142.3 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Ribosomal_S17e PF00833.13 AIC15243.1 - 1.1e-17 63.8 0.7 1.2e-17 63.8 0.5 1.0 1 0 0 1 1 1 1 Ribosomal S17 RRP7 PF12923.2 AIC15243.1 - 0.19 11.7 2.5 0.26 11.3 1.7 1.2 1 0 0 1 1 1 0 Ribosomal RNA-processing protein 7 (RRP7) CGI-121 PF08617.5 AIC15244.1 - 1.1e-13 51.1 0.0 1.5e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Kinase binding protein CGI-121 ThiS PF02597.15 AIC15244.1 - 1.3e-09 38.3 0.5 6.2e-09 36.1 0.0 2.3 2 1 1 3 3 3 1 ThiS family Urm1 PF09138.6 AIC15244.1 - 0.0013 18.8 0.1 0.0036 17.3 0.1 1.9 1 1 0 1 1 1 1 Urm1 (Ubiquitin related modifier) TrkA_C PF02080.16 AIC15244.1 - 0.04 13.5 0.5 0.45 10.1 0.1 2.4 2 0 0 2 2 2 0 TrkA-C domain TGS PF02824.16 AIC15244.1 - 0.12 12.1 0.1 0.27 11.0 0.1 1.6 1 0 0 1 1 1 0 TGS domain THUMP PF02926.12 AIC15245.1 - 6.3e-15 55.3 0.5 7.6e-15 55.0 0.4 1.2 1 0 0 1 1 1 1 THUMP domain Sua5_yciO_yrdC PF01300.13 AIC15246.1 - 1.2e-45 154.9 0.0 1.3e-45 154.7 0.0 1.0 1 0 0 1 1 1 1 Telomere recombination Hydantoinase_A PF01968.13 AIC15247.1 - 5.2e-52 176.7 5.6 5.2e-52 176.7 3.9 2.1 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.8 AIC15247.1 - 3e-24 85.5 1.4 3e-24 85.5 1.0 3.6 5 0 0 5 5 5 2 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.1 AIC15247.1 - 1.8e-08 33.1 4.7 1.6e-05 23.4 0.8 2.3 2 0 0 2 2 2 2 MutL protein BcrAD_BadFG PF01869.15 AIC15247.1 - 1.7e-05 24.2 3.6 0.00029 20.2 0.4 3.4 3 1 1 4 4 4 1 BadF/BadG/BcrA/BcrD ATPase family FGGY_N PF00370.16 AIC15247.1 - 3.2e-05 23.3 1.3 7.8e-05 22.1 0.9 1.7 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain DUF4229 PF14012.1 AIC15248.1 - 0.006 16.4 1.7 0.0072 16.1 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4229) Branch_AA_trans PF05525.8 AIC15249.1 - 0.0013 17.4 0.1 0.0015 17.2 0.1 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport protein KbaA PF14089.1 AIC15249.1 - 0.0014 18.1 0.2 0.0014 18.1 0.1 1.0 1 0 0 1 1 1 1 KinB-signalling pathway activation in sporulation DUF4131 PF13567.1 AIC15249.1 - 0.0035 16.7 0.7 0.056 12.8 0.0 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4131) DUF1129 PF06570.6 AIC15249.1 - 0.0044 16.3 0.4 0.0051 16.1 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) YfhO PF09586.5 AIC15249.1 - 0.0047 15.0 0.2 0.0049 14.9 0.1 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO EpsG PF14897.1 AIC15249.1 - 0.0052 15.7 0.3 0.0059 15.5 0.2 1.1 1 0 0 1 1 1 1 EpsG family Bax1-I PF01027.15 AIC15249.1 - 0.0073 15.9 0.1 0.0085 15.7 0.1 1.1 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 7TMR-DISM_7TM PF07695.6 AIC15249.1 - 0.016 14.8 0.1 0.018 14.7 0.1 1.1 1 0 0 1 1 1 0 7TM diverse intracellular signalling Polysacc_synt_C PF14667.1 AIC15249.1 - 0.017 14.9 1.8 0.024 14.4 1.2 1.3 1 1 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain CitMHS PF03600.11 AIC15249.1 - 0.024 13.2 0.1 0.026 13.0 0.1 1.0 1 0 0 1 1 1 0 Citrate transporter DUF2919 PF11143.3 AIC15249.1 - 0.025 14.4 0.4 0.1 12.4 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2919) DUF2339 PF10101.4 AIC15249.1 - 0.031 12.5 0.1 0.033 12.4 0.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) Cyto_ox_2 PF02322.10 AIC15249.1 - 0.045 12.9 1.6 0.073 12.2 1.2 1.4 1 1 0 1 1 1 0 Cytochrome oxidase subunit II TB2_DP1_HVA22 PF03134.14 AIC15249.1 - 0.049 13.3 0.1 0.062 13.0 0.0 1.3 1 0 0 1 1 1 0 TB2/DP1, HVA22 family INSIG PF07281.7 AIC15249.1 - 0.052 12.8 0.1 0.059 12.6 0.1 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) 5TM-5TMR_LYT PF07694.7 AIC15249.1 - 0.062 12.6 0.4 0.073 12.4 0.3 1.2 1 0 0 1 1 1 0 5TMR of 5TMR-LYT GpcrRhopsn4 PF10192.4 AIC15249.1 - 0.064 12.4 0.4 0.074 12.2 0.3 1.0 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain TctB PF07331.6 AIC15249.1 - 0.066 12.8 1.5 0.13 11.9 1.0 1.6 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF4153 PF13687.1 AIC15249.1 - 0.067 12.7 0.6 0.14 11.6 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4153) Ceramidase PF05875.7 AIC15249.1 - 0.073 12.1 0.3 0.09 11.8 0.2 1.0 1 0 0 1 1 1 0 Ceramidase SLAC1 PF03595.12 AIC15249.1 - 0.1 11.2 2.7 0.49 8.9 2.2 1.8 1 1 0 1 1 1 0 Voltage-dependent anion channel YwiC PF14256.1 AIC15249.1 - 0.16 12.0 1.3 0.42 10.6 0.9 1.7 1 1 0 1 1 1 0 YwiC-like protein COX14 PF14880.1 AIC15249.1 - 0.18 11.4 1.0 0.46 10.1 0.2 1.9 1 1 1 2 2 2 0 Cytochrome oxidase c assembly DUF1206 PF06724.6 AIC15249.1 - 0.29 10.9 3.7 0.66 9.7 0.0 2.6 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1206) O-antigen_lig PF13425.1 AIC15249.1 - 0.37 10.7 2.4 2.5 8.1 1.7 1.9 1 1 0 1 1 1 0 O-antigen ligase like membrane protein DUF4418 PF14387.1 AIC15249.1 - 0.42 10.3 1.8 4 7.2 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4418) DUF202 PF02656.10 AIC15249.1 - 0.45 10.7 3.8 4.5 7.5 2.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF202) VPEP PF07589.6 AIC15249.1 - 0.53 10.2 4.7 1.3 8.9 0.1 2.7 3 0 0 3 3 3 0 PEP-CTERM motif Tetraspannin PF00335.15 AIC15249.1 - 0.56 9.4 2.9 1.5 8.0 2.0 1.6 1 1 0 1 1 1 0 Tetraspanin family Rab5ip PF07019.7 AIC15249.1 - 0.97 9.6 4.3 4 7.6 0.1 2.3 2 1 0 2 2 2 0 Rab5-interacting protein (Rab5ip) ECF-ribofla_trS PF07155.7 AIC15249.1 - 4.5 6.9 7.4 22 4.7 5.2 1.8 1 1 0 1 1 1 0 ECF-type riboflavin transporter, S component DDE_Tnp_IS240 PF13610.1 AIC15250.1 - 1.7e-19 70.1 0.8 3.7e-19 69.0 0.5 1.6 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC15250.1 - 8.6e-10 38.7 0.1 1.6e-09 37.8 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 AIC15250.1 - 0.00093 18.6 1.0 0.0033 16.8 0.7 2.0 1 1 0 1 1 1 1 Integrase core domain SWIM PF04434.12 AIC15250.1 - 0.011 15.2 0.5 0.011 15.2 0.4 1.8 2 0 0 2 2 2 0 SWIM zinc finger Elf1 PF05129.8 AIC15250.1 - 0.014 15.0 0.5 0.031 13.9 0.4 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF2135 PF09906.4 AIC15250.1 - 0.017 15.0 0.0 0.046 13.6 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2135) Zn_Tnp_IS1 PF03811.8 AIC15250.1 - 0.059 12.8 1.8 0.14 11.6 1.3 1.7 1 0 0 1 1 1 0 InsA N-terminal domain DDE_Tnp_IS66 PF03050.9 AIC15250.1 - 0.06 12.5 0.6 0.1 11.7 0.0 1.7 2 0 0 2 2 2 0 Transposase IS66 family zf-Dof PF02701.10 AIC15250.1 - 0.4 10.6 5.6 1.3 8.9 3.7 2.1 1 1 1 2 2 2 0 Dof domain, zinc finger C1_4 PF07975.7 AIC15250.1 - 5.5 7.0 6.8 8.4 6.4 2.4 2.5 2 1 0 2 2 2 0 TFIIH C1-like domain Antitoxin-MazE PF04014.13 AIC15251.1 - 7.9e-05 22.2 0.2 0.00016 21.2 0.1 1.6 1 1 0 1 1 1 1 Antidote-toxin recognition MazE DUF267 PF03268.9 AIC15252.1 - 0.15 10.8 0.8 0.34 9.7 0.1 1.8 1 1 1 2 2 2 0 Caenorhabditis protein of unknown function, DUF267 Ribosomal_L29e PF01779.12 AIC15254.1 - 0.15 11.9 0.2 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 Ribosomal L29e protein family DDE_Tnp_IS240 PF13610.1 AIC15255.1 - 1.8e-16 60.3 0.5 2.3e-16 60.0 0.4 1.1 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC15255.1 - 1.2e-07 31.9 0.0 1.7e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 AIC15255.1 - 2.4e-06 26.9 0.2 5.7e-06 25.7 0.1 1.7 1 1 0 1 1 1 1 Integrase core domain MULE PF10551.4 AIC15255.1 - 0.06 13.5 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 MULE transposase domain PhnH PF05845.7 AIC15255.1 - 0.13 11.6 0.0 0.25 10.7 0.0 1.5 2 0 0 2 2 2 0 Bacterial phosphonate metabolism protein (PhnH) V4R PF02830.13 AIC15256.1 - 3.5e-13 49.1 0.2 5.5e-13 48.5 0.2 1.4 1 0 0 1 1 1 1 V4R domain HTH_24 PF13412.1 AIC15257.1 - 3.9e-08 32.5 0.9 5.8e-08 31.9 0.1 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC15257.1 - 6.6e-07 28.7 0.4 2.1e-06 27.1 0.1 2.0 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain TrmB PF01978.14 AIC15257.1 - 0.0081 15.8 0.0 0.016 14.9 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.1 AIC15257.1 - 0.01 15.4 0.0 0.044 13.4 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain HTH_20 PF12840.2 AIC15257.1 - 0.017 14.9 0.0 0.034 13.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_psq PF05225.11 AIC15257.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain UDPG_MGDP_dh PF00984.14 AIC15258.1 - 1.4e-18 66.8 0.2 2.5e-18 66.0 0.1 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.9 AIC15258.1 - 4.9e-11 42.3 0.0 3.5e-05 23.2 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.10 AIC15258.1 - 0.00011 22.1 0.0 0.00016 21.5 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 AIC15258.1 - 0.0003 19.9 0.0 0.00044 19.4 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 AIC15258.1 - 0.0009 18.9 0.1 0.0046 16.6 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 AIC15258.1 - 0.0019 18.1 0.0 0.0053 16.7 0.0 1.7 1 0 0 1 1 1 1 TrkA-N domain NAD_binding_8 PF13450.1 AIC15258.1 - 0.062 13.3 0.1 0.93 9.5 0.0 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Methyltransf_18 PF12847.2 AIC15258.1 - 0.063 13.8 0.0 0.16 12.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain ImpE PF07024.8 AIC15258.1 - 0.1 12.5 0.0 6.3 6.7 0.0 2.4 1 1 1 2 2 2 0 ImpE protein HTH_45 PF14947.1 AIC15259.1 - 2.5e-16 59.2 0.1 2.7e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix Mrr_N PF14338.1 AIC15259.1 - 0.025 14.6 0.1 0.033 14.2 0.1 1.1 1 0 0 1 1 1 0 Mrr N-terminal domain HTH_24 PF13412.1 AIC15260.1 - 2.1e-06 26.9 0.5 4e-06 26.1 0.3 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC15260.1 - 0.00053 19.4 0.2 0.0011 18.4 0.2 1.6 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.7 AIC15260.1 - 0.0018 17.8 0.2 0.0044 16.6 0.1 1.6 1 0 0 1 1 1 1 HTH domain AsnC_trans_reg PF01037.16 AIC15260.1 - 0.0064 16.1 0.0 0.014 15.0 0.0 1.6 1 0 0 1 1 1 1 AsnC family HTH_20 PF12840.2 AIC15260.1 - 0.0092 15.7 0.1 0.024 14.4 0.1 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 AIC15260.1 - 0.032 13.9 0.1 0.071 12.8 0.1 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.1 AIC15260.1 - 0.041 13.5 0.0 0.097 12.3 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_IclR PF09339.5 AIC15260.1 - 0.13 11.8 0.1 0.29 10.7 0.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_psq PF05225.11 AIC15260.1 - 0.13 11.8 0.2 0.4 10.2 0.0 1.8 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_24 PF13412.1 AIC15261.1 - 1.1e-06 27.9 2.2 5e-06 25.8 0.1 2.6 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC15261.1 - 0.00047 19.6 0.1 0.0029 17.0 0.1 2.1 2 1 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.7 AIC15261.1 - 0.0013 18.3 0.2 0.0034 16.9 0.1 1.7 1 0 0 1 1 1 1 HTH domain HTH_20 PF12840.2 AIC15261.1 - 0.0018 18.0 0.6 0.0077 16.0 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain ACT_4 PF13291.1 AIC15261.1 - 0.017 15.4 0.2 0.067 13.5 0.0 2.1 2 1 0 2 2 2 0 ACT domain TrmB PF01978.14 AIC15261.1 - 0.02 14.5 0.1 0.1 12.3 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_23 PF13384.1 AIC15261.1 - 0.034 13.8 0.0 0.086 12.5 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_IclR PF09339.5 AIC15261.1 - 0.077 12.5 0.9 0.23 11.0 0.1 2.1 3 0 0 3 3 3 0 IclR helix-turn-helix domain HTH_psq PF05225.11 AIC15261.1 - 0.13 11.8 0.0 0.29 10.7 0.0 1.6 1 0 0 1 1 1 0 helix-turn-helix, Psq domain DUF2116 PF09889.4 AIC15262.1 - 0.02 14.6 11.8 0.34 10.7 4.8 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) ASFV_p27 PF06556.6 AIC15262.1 - 0.094 12.6 0.7 0.13 12.1 0.5 1.2 1 0 0 1 1 1 0 IAP-like protein p27 C-terminus DUF3357 PF11837.3 AIC15265.1 - 0.037 13.8 1.3 0.069 13.0 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Pax2_C PF12403.3 AIC15265.1 - 0.059 13.0 0.1 0.15 11.7 0.0 1.7 1 1 0 1 1 1 0 Paired-box protein 2 C terminal PsbQ PF05757.6 AIC15265.1 - 0.4 10.0 2.1 0.35 10.2 0.3 1.6 1 1 1 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) ETRAMP PF09716.5 AIC15265.1 - 0.72 9.8 2.7 0.49 10.3 0.2 1.9 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SIS PF01380.17 AIC15266.1 - 7.3e-51 171.1 2.4 2.1e-30 105.0 1.3 2.3 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.1 AIC15266.1 - 1.1e-24 86.9 0.0 2.1e-24 85.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 AIC15266.1 - 2.9e-19 69.0 0.1 2.2e-15 56.2 0.0 2.7 1 1 1 2 2 2 2 Glutamine amidotransferases class-II GATase_7 PF13537.1 AIC15266.1 - 2.7e-18 65.9 0.0 6.2e-18 64.7 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.1 AIC15266.1 - 1.8e-05 23.6 0.0 3.2e-05 22.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II SIS_2 PF13580.1 AIC15266.1 - 0.00012 21.7 2.7 0.0003 20.5 0.3 2.5 1 1 1 2 2 2 1 SIS domain Sprouty PF05210.8 AIC15267.1 - 0.033 14.2 0.4 0.035 14.1 0.3 1.0 1 0 0 1 1 1 0 Sprouty protein (Spry) Sina PF03145.11 AIC15267.1 - 0.21 11.2 1.1 0.2 11.2 0.8 1.1 1 0 0 1 1 1 0 Seven in absentia protein family F5_F8_type_C PF00754.20 AIC15269.1 - 3.3e-14 52.8 1.9 3.3e-14 52.8 1.3 2.2 3 0 0 3 3 3 1 F5/8 type C domain Mo-co_dimer PF03404.11 AIC15269.1 - 7.1e-05 22.4 0.3 0.00021 20.9 0.2 1.7 1 1 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Big_3_4 PF13754.1 AIC15269.1 - 0.0002 21.5 0.3 0.0002 21.5 0.2 3.5 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 3) CBM_6 PF03422.10 AIC15269.1 - 0.0014 18.8 0.5 0.0014 18.8 0.4 2.8 3 0 0 3 3 3 1 Carbohydrate binding module (family 6) CHB_HEX_C PF03174.8 AIC15270.1 - 2.7e-128 418.0 82.2 3.6e-23 81.1 4.4 7.9 7 0 0 7 7 7 6 Chitobiase/beta-hexosaminidase C-terminal domain CHB_HEX_C_1 PF13290.1 AIC15270.1 - 1.7e-111 364.0 78.8 3e-20 71.7 4.4 8.2 8 0 0 8 8 8 6 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 AIC15270.1 - 2.4e-107 351.0 71.4 1.1e-19 70.2 2.4 7.7 7 0 0 7 7 7 6 Fn3 associated HYR PF02494.11 AIC15270.1 - 1.7e-14 53.5 14.2 5.5e-07 29.4 1.1 4.6 4 0 0 4 4 4 2 HYR domain Polysacc_deac_1 PF01522.16 AIC15270.1 - 4.3e-10 39.2 0.0 9.7e-10 38.1 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase SWM_repeat PF13753.1 AIC15270.1 - 3e-07 29.8 91.9 0.0001 21.4 8.5 7.0 3 1 3 6 6 6 3 Putative flagellar system-associated repeat Big_3_4 PF13754.1 AIC15270.1 - 8.2e-07 29.2 13.3 1.3e-05 25.4 0.3 12.8 13 1 0 13 13 13 5 Bacterial Ig-like domain (group 3) Big_3_2 PF12245.3 AIC15270.1 - 5.5e-06 25.8 12.2 2.9 7.5 0.0 7.9 8 0 0 8 8 8 1 Bacterial Ig-like domain (group 3) Glyco_hydro_57 PF03065.10 AIC15270.1 - 0.027 13.3 0.0 0.048 12.5 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 TrkA_C PF02080.16 AIC15270.1 - 0.035 13.6 0.0 19 4.9 0.0 3.3 3 0 0 3 3 3 0 TrkA-C domain Beta_helix PF13229.1 AIC15271.1 - 1.6e-20 73.4 27.9 5.4e-14 52.2 9.8 2.6 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.8 AIC15271.1 - 2.4e-19 69.4 16.8 6.5e-19 68.0 11.6 1.7 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) Pectate_lyase_3 PF12708.2 AIC15271.1 - 2.8e-06 27.6 1.7 2.8e-06 27.6 1.2 2.2 1 1 1 2 2 2 1 Pectate lyase superfamily protein DUF1565 PF07602.6 AIC15271.1 - 8.2e-05 21.8 10.6 0.0011 18.1 4.7 2.7 1 1 0 2 2 2 2 Protein of unknown function (DUF1565) Glycos_transf_2 PF00535.21 AIC15272.1 - 4.6e-32 111.0 0.0 1e-31 109.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AIC15272.1 - 1.4e-26 93.7 0.7 6.7e-26 91.4 0.5 1.9 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.10 AIC15272.1 - 2.1e-17 62.7 0.2 7.3e-16 57.6 0.1 2.1 1 1 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 AIC15272.1 - 2.4e-12 46.9 4.3 2.4e-12 46.9 3.0 2.4 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 AIC15272.1 - 5.9e-09 35.4 2.2 7.9e-08 31.7 0.7 2.6 2 1 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 AIC15272.1 - 2.8e-05 23.3 0.1 4.2e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 MARVEL PF01284.18 AIC15272.1 - 0.62 9.8 8.8 1.1 9.0 0.1 2.4 2 0 0 2 2 2 0 Membrane-associating domain YjgF_endoribonc PF14588.1 AIC15273.1 - 2.4e-42 144.3 0.0 2.8e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.16 AIC15273.1 - 2.8e-22 78.7 0.0 4.2e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 Endoribonuclease L-PSP DHHA1 PF02272.14 AIC15275.1 - 1.7e-12 46.8 0.2 5.2e-12 45.2 0.1 1.8 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.15 AIC15275.1 - 5.7e-07 29.2 0.1 1.1e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 DHH family Thioredox_DsbH PF03190.10 AIC15278.1 - 2.8e-33 114.9 0.0 4.4e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Glyco_hydro_88 PF07470.8 AIC15278.1 - 2.5e-11 43.2 0.0 0.00022 20.4 0.0 2.8 2 1 0 2 2 2 2 Glycosyl Hydrolase Family 88 C5-epim_C PF06662.8 AIC15278.1 - 6.3e-08 32.1 1.8 0.00033 19.9 0.1 3.7 4 0 0 4 4 4 2 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_76 PF03663.9 AIC15278.1 - 2.3e-07 30.5 0.0 3.8e-06 26.5 0.0 2.5 2 1 0 2 2 2 1 Glycosyl hydrolase family 76 GlcNAc_2-epim PF07221.6 AIC15278.1 - 1.3e-05 24.3 0.7 0.23 10.4 0.0 3.0 2 1 0 3 3 3 2 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) DUF1680 PF07944.7 AIC15278.1 - 0.002 16.4 0.0 0.051 11.8 0.0 2.5 3 0 0 3 3 3 1 Putative glycosyl hydrolase of unknown function (DUF1680) PMBR PF09373.5 AIC15278.1 - 0.007 16.2 0.1 8.3 6.5 0.0 3.2 2 0 0 2 2 2 2 Pseudomurein-binding repeat BPD_transp_2 PF02653.11 AIC15280.1 - 0.015 14.2 0.2 0.015 14.2 0.1 1.0 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component DUF2975 PF11188.3 AIC15280.1 - 0.023 14.3 2.2 0.031 14.0 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) PrgI PF12666.2 AIC15280.1 - 0.06 13.5 0.1 0.067 13.3 0.1 1.2 1 0 0 1 1 1 0 PrgI family protein DUF2681 PF10883.3 AIC15280.1 - 0.18 12.0 1.3 1.9 8.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Pyridox_ox_2 PF12900.2 AIC15281.1 - 6.1e-25 87.7 0.0 7.5e-25 87.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxidase PF01243.15 AIC15281.1 - 4.7e-16 58.5 0.0 8.4e-16 57.7 0.0 1.4 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.7 AIC15281.1 - 4.8e-05 22.8 0.0 6.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Putative FMN-binding domain SAE2 PF08573.5 AIC15282.1 - 0.55 10.9 3.0 0.77 10.5 2.1 1.4 1 1 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus HTH_45 PF14947.1 AIC15283.1 - 1.5e-19 69.6 0.4 1.6e-19 69.4 0.2 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC15283.1 - 0.003 17.1 0.2 0.0036 16.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) PadR PF03551.9 AIC15284.1 - 2.6e-10 39.9 0.0 9.5e-10 38.1 0.0 1.9 1 1 1 2 2 2 1 Transcriptional regulator PadR-like family HTH_45 PF14947.1 AIC15284.1 - 0.00017 21.3 0.0 0.00034 20.3 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix HemN_C PF06969.11 AIC15284.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.7 1 0 0 1 1 1 0 HemN C-terminal domain Ribonuc_L-PSP PF01042.16 AIC15285.1 - 8.5e-24 83.6 0.3 1e-23 83.3 0.2 1.0 1 0 0 1 1 1 1 Endoribonuclease L-PSP MEDS PF14417.1 AIC15287.1 - 1.9e-05 23.7 0.0 3.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain KaiC PF06745.8 AIC15287.1 - 0.04 13.0 0.0 0.063 12.3 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF4396 PF14342.1 AIC15289.1 - 5.7e-26 91.2 11.4 7.4e-26 90.9 7.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) UPF0086 PF01868.11 AIC15291.1 - 0.0075 15.8 0.0 0.12 11.9 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function UPF0086 Na_H_Exchanger PF00999.16 AIC15292.1 - 2.1e-64 217.4 49.1 2.6e-64 217.1 34.1 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TauE PF01925.14 AIC15294.1 - 1.1e-37 129.7 38.3 1.4e-37 129.4 26.6 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Herpes_glycop PF01528.11 AIC15294.1 - 3.6 6.1 7.9 0.61 8.7 1.8 2.1 2 0 0 2 2 2 0 Herpesvirus glycoprotein M Glug PF07581.7 AIC15294.1 - 8.8 6.7 17.6 31 5.0 0.1 5.4 5 0 0 5 5 5 0 The GLUG motif CRCB PF02537.10 AIC15297.1 - 8.5e-23 80.4 9.1 9.7e-23 80.2 6.3 1.0 1 0 0 1 1 1 1 CrcB-like protein DUF1229 PF06797.6 AIC15297.1 - 0.038 12.8 0.6 0.039 12.7 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) DUF3681 PF12442.3 AIC15297.1 - 0.37 10.9 5.7 0.24 11.5 2.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3681) DUF2157 PF09925.4 AIC15297.1 - 2.1 7.9 6.2 4.6 6.8 4.3 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF190 PF02641.10 AIC15298.1 - 1.8e-21 75.8 0.3 2.1e-21 75.6 0.2 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 Cation_efflux PF01545.16 AIC15299.1 - 1.2e-49 168.9 5.5 1.3e-49 168.8 3.8 1.0 1 0 0 1 1 1 1 Cation efflux family Rab5ip PF07019.7 AIC15299.1 - 0.15 12.2 0.3 0.15 12.2 0.2 3.1 2 2 1 3 3 3 0 Rab5-interacting protein (Rab5ip) Glycos_transf_4 PF00953.16 AIC15299.1 - 0.58 9.9 9.1 0.045 13.5 2.2 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 4 Cation_ATPase_C PF00689.16 AIC15299.1 - 1.8 8.0 7.8 0.21 11.0 2.2 1.7 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus DUF3147 PF11345.3 AIC15300.1 - 0.048 13.6 10.6 0.53 10.3 6.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3147) DUF3169 PF11368.3 AIC15300.1 - 1.1 8.4 5.9 0.32 10.1 1.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) YqhR PF11085.3 AIC15300.1 - 2.5 7.6 7.7 0.61 9.5 2.0 2.1 1 1 1 2 2 2 0 Conserved membrane protein YqhR DUF3040 PF11239.3 AIC15302.1 - 0.077 13.0 2.7 0.082 12.9 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) DUF2619 PF10942.3 AIC15302.1 - 0.69 9.9 3.3 0.9 9.5 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2619) IncA PF04156.9 AIC15302.1 - 1.4 8.5 4.8 1.6 8.2 3.3 1.1 1 0 0 1 1 1 0 IncA protein Thioredoxin_4 PF13462.1 AIC15303.1 - 7.6e-35 120.3 0.0 1.1e-34 119.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.15 AIC15303.1 - 3e-14 53.0 0.4 9.5e-13 48.1 0.1 2.4 2 1 0 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.1 AIC15303.1 - 2e-08 34.4 0.0 1.2e-07 31.9 0.0 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain ETRAMP PF09716.5 AIC15303.1 - 0.023 14.6 0.2 0.036 14.0 0.2 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) AAA_27 PF13514.1 AIC15304.1 - 0.00042 18.1 31.6 0.022 12.4 15.4 2.4 1 1 1 2 2 2 2 AAA domain DUF3542 PF12061.3 AIC15304.1 - 0.0075 15.2 0.0 0.013 14.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3542) ADIP PF11559.3 AIC15304.1 - 0.051 13.4 18.3 0.34 10.8 5.0 2.9 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Bystin PF05291.6 AIC15304.1 - 0.057 12.3 2.2 0.28 10.0 1.5 2.2 1 1 0 1 1 1 0 Bystin GLTSCR1 PF15249.1 AIC15304.1 - 0.11 12.6 14.2 0.12 12.5 0.4 4.0 3 1 1 4 4 4 0 Glioma tumor suppressor candidate region IF-2B PF01008.12 AIC15304.1 - 0.18 10.7 5.5 0.038 12.9 1.1 1.9 2 0 0 2 2 2 0 Initiation factor 2 subunit family ParB PF08775.5 AIC15304.1 - 0.27 11.5 13.4 0.14 12.4 0.6 4.7 3 1 3 6 6 6 0 ParB family Cob_adeno_trans PF01923.13 AIC15304.1 - 0.43 10.3 12.9 1.5 8.5 2.6 3.7 2 2 2 4 4 4 0 Cobalamin adenosyltransferase Syntaxin-6_N PF09177.6 AIC15304.1 - 0.72 10.2 17.8 2.2 8.7 0.0 4.8 3 2 2 5 5 5 0 Syntaxin 6, N-terminal Baculo_PEP_C PF04513.7 AIC15304.1 - 0.79 9.5 13.0 2.4 7.9 1.2 4.4 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fib_alpha PF08702.5 AIC15304.1 - 1.3 9.0 14.6 3.9 7.6 0.3 4.2 1 1 4 5 5 5 0 Fibrinogen alpha/beta chain family TMF_TATA_bd PF12325.3 AIC15304.1 - 1.8 8.2 23.9 0.75 9.5 0.3 5.0 2 2 3 5 5 5 0 TATA element modulatory factor 1 TATA binding DUF2450 PF10475.4 AIC15304.1 - 2.7 6.7 10.7 0.36 9.6 3.2 2.4 2 1 1 3 3 3 0 Protein of unknown function N-terminal domain (DUF2450) CDC37_N PF03234.9 AIC15304.1 - 3.2 8.0 20.3 0.57 10.4 1.6 3.7 1 1 3 4 4 4 0 Cdc37 N terminal kinase binding DUF883 PF05957.8 AIC15304.1 - 6.4 7.2 19.0 2.4 8.6 1.5 4.6 2 2 2 5 5 5 0 Bacterial protein of unknown function (DUF883) ERp29 PF07749.7 AIC15304.1 - 9.2 6.9 16.5 0.51 10.9 2.7 4.0 2 1 3 5 5 5 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF2627 PF11118.3 AIC15305.1 - 0.014 15.4 2.4 0.32 11.1 1.4 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2627) DUF4491 PF14898.1 AIC15305.1 - 0.065 13.3 1.0 0.15 12.2 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4491) DUF1673 PF07895.6 AIC15305.1 - 0.34 10.4 2.1 1 8.8 1.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1673) DUF1049 PF06305.6 AIC15306.1 - 0.039 13.4 0.2 0.059 12.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1049) DUF2613 PF11021.3 AIC15306.1 - 0.12 12.1 1.3 0.18 11.5 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2613) EpuA PF11772.3 AIC15306.1 - 0.55 9.7 2.2 0.86 9.0 1.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta GerPC PF10737.4 AIC15307.1 - 0.18 11.5 1.1 0.25 11.0 0.8 1.2 1 0 0 1 1 1 0 Spore germination protein GerPC Cupin_2 PF07883.6 AIC15308.1 - 5.5e-11 41.8 0.1 6.7e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 AIC15308.1 - 1.3e-05 24.6 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.14 AIC15308.1 - 0.00042 20.0 0.0 0.00052 19.7 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain CENP-C_C PF11699.3 AIC15308.1 - 0.0025 17.7 0.0 0.0031 17.4 0.0 1.1 1 0 0 1 1 1 1 Mif2/CENP-C like Cupin_6 PF12852.2 AIC15308.1 - 0.0062 16.1 0.0 0.0076 15.8 0.0 1.2 1 0 0 1 1 1 1 Cupin ARD PF03079.9 AIC15308.1 - 0.062 13.2 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 ARD/ARD' family CarboxypepD_reg PF13620.1 AIC15311.1 - 0.0018 18.2 0.2 0.021 14.8 0.1 2.6 2 1 1 3 3 3 1 Carboxypeptidase regulatory-like domain DUF1255 PF06865.6 AIC15311.1 - 0.051 13.8 0.0 0.095 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1255) Wzt_C PF14524.1 AIC15311.1 - 0.069 12.8 0.0 0.15 11.7 0.0 1.5 1 1 0 1 1 1 0 Wzt C-terminal domain HTH_45 PF14947.1 AIC15312.1 - 2.9e-06 27.0 0.4 4.9e-06 26.2 0.3 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_20 PF12840.2 AIC15312.1 - 0.00056 19.6 0.0 0.0024 17.6 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_Tnp_ISL3 PF13542.1 AIC15312.1 - 0.0015 17.6 0.0 0.67 9.1 0.0 2.7 3 0 0 3 3 3 2 Helix-turn-helix domain of transposase family ISL3 HTH_5 PF01022.15 AIC15312.1 - 0.0041 16.7 0.1 0.025 14.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 AIC15312.1 - 0.025 13.9 0.5 0.43 9.9 0.1 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_27 PF13463.1 AIC15312.1 - 0.037 14.3 0.0 0.061 13.6 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF4364 PF14277.1 AIC15312.1 - 0.052 13.1 0.1 0.078 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) TrmB PF01978.14 AIC15312.1 - 0.094 12.4 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB BNR_2 PF13088.1 AIC15313.1 - 6.6e-06 25.6 4.6 0.0023 17.2 0.7 3.3 1 1 2 3 3 3 3 BNR repeat-like domain Glyco_hydro_43 PF04616.9 AIC15313.1 - 0.0076 15.3 0.1 0.023 13.7 0.0 1.7 1 1 0 1 1 1 1 Glycosyl hydrolases family 43 DZR PF12773.2 AIC15314.1 - 0.0097 15.7 1.2 0.011 15.5 0.8 1.2 1 0 0 1 1 1 1 Double zinc ribbon Ribosomal_L40e PF01020.12 AIC15314.1 - 0.016 14.8 2.7 0.019 14.5 1.9 1.2 1 0 0 1 1 1 0 Ribosomal L40e family DNA_RNApol_7kD PF03604.8 AIC15314.1 - 0.02 14.3 3.8 0.034 13.6 2.6 1.4 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DnaJ_CXXCXGXG PF00684.14 AIC15314.1 - 0.024 14.6 1.7 0.028 14.4 1.2 1.2 1 0 0 1 1 1 0 DnaJ central domain Paired_CXXCH_1 PF09699.5 AIC15314.1 - 0.024 14.1 0.4 0.54 9.8 0.1 2.1 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) DUF2024 PF09630.5 AIC15314.1 - 0.085 12.5 0.2 0.1 12.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) DUF1752 PF08550.5 AIC15314.1 - 0.098 12.2 2.3 8 6.1 0.2 2.1 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1752) Cytochrome_C7 PF14522.1 AIC15314.1 - 0.17 11.5 2.5 0.45 10.1 1.8 1.6 1 1 0 1 1 1 0 Cytochrome c7 Haem_bd PF14376.1 AIC15314.1 - 0.89 9.2 3.1 0.56 9.8 0.5 1.7 1 1 1 2 2 2 0 Haem-binding domain zf-CCHC PF00098.18 AIC15314.1 - 7 6.7 8.0 6 6.9 1.4 2.2 2 0 0 2 2 2 0 Zinc knuckle ProRS-C_1 PF09180.6 AIC15317.1 - 0.063 13.2 0.1 0.088 12.7 0.1 1.2 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal AdoHcyase PF05221.12 AIC15318.1 - 8.7e-66 221.6 0.1 9.8e-66 221.4 0.1 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.16 AIC15318.1 - 7.7e-56 188.4 4.5 3.9e-55 186.1 2.5 2.1 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.14 AIC15318.1 - 5.6e-11 41.9 1.9 8.4e-11 41.3 0.5 1.9 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.7 AIC15318.1 - 1.6e-07 30.8 0.6 3.9e-07 29.5 0.4 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain ELFV_dehydrog PF00208.16 AIC15318.1 - 0.0025 17.4 0.9 0.0047 16.5 0.7 1.4 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Shikimate_DH PF01488.15 AIC15318.1 - 0.0043 17.1 2.0 0.035 14.1 0.6 2.3 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.13 AIC15318.1 - 0.0058 16.6 0.5 0.015 15.2 0.1 1.9 2 0 0 2 2 2 1 TrkA-N domain F420_oxidored PF03807.12 AIC15318.1 - 0.048 14.0 1.3 0.13 12.7 0.9 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.16 AIC15318.1 - 0.19 11.2 5.0 0.14 11.6 0.7 2.3 1 1 1 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Pribosyltran PF00156.22 AIC15319.1 - 1.1e-23 83.2 1.2 1.9e-23 82.5 0.8 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 AIC15319.1 - 1.8e-06 27.2 0.1 2.7e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 AIC15319.1 - 0.00028 20.2 0.1 0.0021 17.3 0.0 2.1 2 0 0 2 2 2 1 Phosphoribosyl transferase Lysine_decarbox PF03641.9 AIC15320.1 - 8.6e-07 28.8 0.2 5.9e-06 26.1 0.0 2.2 1 1 1 2 2 2 1 Possible lysine decarboxylase DNA_processg_A PF02481.10 AIC15320.1 - 6.9e-05 21.8 0.2 0.002 17.0 0.1 2.1 2 0 0 2 2 2 2 DNA recombination-mediator protein A DAGK_cat PF00781.19 AIC15320.1 - 0.22 10.9 5.5 0.64 9.4 0.2 2.3 1 1 1 2 2 2 0 Diacylglycerol kinase catalytic domain 3HCDH_N PF02737.13 AIC15321.1 - 5.6e-65 218.3 0.0 1.5e-64 216.9 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.17 AIC15321.1 - 1.3e-31 108.8 0.4 1.6e-25 89.3 0.0 3.2 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.18 AIC15321.1 - 6.2e-08 32.5 0.0 9.9e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.10 AIC15321.1 - 4.2e-05 23.4 0.1 7e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.9 AIC15321.1 - 0.017 14.4 0.0 0.028 13.8 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain F420_oxidored PF03807.12 AIC15321.1 - 0.025 15.0 0.3 0.11 12.9 0.2 2.2 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Ribosomal_L39 PF00832.15 AIC15322.1 - 6.6e-19 67.0 14.0 8.3e-19 66.7 9.7 1.2 1 0 0 1 1 1 1 Ribosomal L39 protein Ribosomal_L31e PF01198.14 AIC15323.1 - 1.1e-25 89.0 2.6 1.7e-25 88.5 1.8 1.2 1 0 0 1 1 1 1 Ribosomal protein L31e NUMOD3 PF07460.6 AIC15324.1 - 0.12 12.3 2.3 0.16 11.8 1.6 1.1 1 0 0 1 1 1 0 NUMOD3 motif (2 copies) DnaJ_CXXCXGXG PF00684.14 AIC15325.1 - 0.0045 17.0 4.5 0.0073 16.3 3.1 1.4 1 1 0 1 1 1 1 DnaJ central domain zf-trcl PF13451.1 AIC15325.1 - 0.045 13.3 0.3 0.045 13.3 0.2 2.8 3 0 0 3 3 3 0 Probable zinc-binding domain DUF983 PF06170.7 AIC15325.1 - 0.052 13.6 0.3 0.052 13.6 0.2 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF983) zf-C2H2 PF00096.21 AIC15325.1 - 0.63 10.5 0.2 0.63 10.5 0.2 3.4 3 1 0 3 3 3 0 Zinc finger, C2H2 type DUF2175 PF09943.4 AIC15325.1 - 1.4 9.0 5.1 0.16 12.0 0.6 1.7 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Tubulin PF00091.20 AIC15326.1 - 3.6e-11 43.3 0.2 4.4e-09 36.4 0.0 2.1 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain NAD_binding_7 PF13241.1 AIC15326.1 - 0.085 13.1 0.2 0.53 10.5 0.0 2.3 3 1 0 3 3 3 0 Putative NAD(P)-binding Radical_SAM PF04055.16 AIC15327.1 - 1.3e-23 83.9 0.0 2.2e-23 83.2 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.15 AIC15327.1 - 1e-17 63.7 0.2 3.7e-17 61.9 0.0 2.1 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 DUF2232 PF09991.4 AIC15330.1 - 0.0012 17.9 1.1 0.0013 17.7 0.7 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2232) ABC_membrane PF00664.18 AIC15330.1 - 0.0032 16.9 1.4 0.0034 16.8 1.0 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region IncA PF04156.9 AIC15330.1 - 3.1 7.3 6.1 3.4 7.2 4.2 1.1 1 0 0 1 1 1 0 IncA protein DUF1049 PF06305.6 AIC15330.1 - 4.2 6.9 7.5 6.9 6.2 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1049) AhpC-TSA PF00578.16 AIC15332.1 - 8.8e-25 86.7 0.0 1.1e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AIC15332.1 - 6.1e-18 64.7 0.0 7.3e-18 64.5 0.0 1.1 1 0 0 1 1 1 1 Redoxin GSHPx PF00255.14 AIC15332.1 - 8.3e-08 31.5 0.0 1.2e-07 31.0 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin_8 PF13905.1 AIC15332.1 - 0.00033 20.7 0.0 0.00043 20.3 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like SCO1-SenC PF02630.9 AIC15332.1 - 0.0018 17.8 0.0 0.0027 17.3 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_2 PF13098.1 AIC15332.1 - 0.0033 17.5 0.0 0.0051 16.9 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like domain DAO PF01266.19 AIC15333.1 - 5.5e-09 35.3 0.4 0.0022 16.9 0.0 2.4 2 1 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.9 AIC15333.1 - 9.2e-07 28.9 0.6 8.3e-06 25.8 0.3 2.2 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.14 AIC15333.1 - 1.7e-05 24.0 0.9 0.046 12.7 0.7 3.2 3 0 0 3 3 3 1 FAD binding domain FAD_oxidored PF12831.2 AIC15333.1 - 4.8e-05 22.6 0.7 7.2e-05 22.0 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AIC15333.1 - 8.5e-05 21.5 1.1 0.00015 20.7 0.8 1.5 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.9 AIC15333.1 - 0.00019 20.0 2.8 0.00019 20.0 1.9 2.0 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.12 AIC15333.1 - 0.00037 19.6 0.3 0.00085 18.4 0.2 1.5 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.1 AIC15333.1 - 0.00064 19.8 0.1 0.0012 18.9 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 AIC15333.1 - 0.00072 19.5 1.7 0.002 18.0 0.3 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain GIDA PF01134.17 AIC15333.1 - 0.014 14.3 0.5 0.031 13.1 0.3 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.22 AIC15333.1 - 0.041 14.2 0.7 0.12 12.7 0.5 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fer4_7 PF12838.2 AIC15333.1 - 0.13 12.6 3.0 0.28 11.6 2.1 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4 PF00037.22 AIC15333.1 - 2 8.1 4.5 0.57 9.8 0.8 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_alpha PF00766.14 AIC15334.1 - 4e-28 96.8 0.1 1.1e-27 95.5 0.1 1.7 1 0 0 1 1 1 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.16 AIC15334.1 - 4.2e-16 59.0 0.0 8.8e-16 58.0 0.0 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF PF01012.16 AIC15335.1 - 2.8e-21 75.9 0.1 4e-21 75.4 0.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain HD_4 PF13328.1 AIC15336.1 - 1.5e-15 57.2 0.2 2.1e-15 56.7 0.1 1.2 1 0 0 1 1 1 1 HD domain MannoseP_isomer PF01050.13 AIC15337.1 - 2.4e-22 79.1 0.0 2.7e-22 79.0 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.6 AIC15337.1 - 8e-09 34.8 0.0 1.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Cupin domain CENP-C_C PF11699.3 AIC15337.1 - 0.075 13.0 0.0 0.097 12.6 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like DUF1255 PF06865.6 AIC15337.1 - 0.077 13.2 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1255) DUF4066 PF13278.1 AIC15338.1 - 0.073 12.3 0.0 0.076 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative amidotransferase zf-FCS PF06467.9 AIC15338.1 - 1 9.0 4.5 2.7 7.6 0.2 2.3 2 0 0 2 2 2 0 MYM-type Zinc finger with FCS sequence motif HTH_20 PF12840.2 AIC15339.1 - 9.4e-16 57.3 0.3 1.9e-15 56.4 0.0 1.6 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC15339.1 - 1.1e-12 47.3 0.0 3.2e-12 45.9 0.0 1.8 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 AIC15339.1 - 5.3e-12 44.9 0.0 1.2e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC15339.1 - 3.2e-08 33.1 0.0 7.8e-08 31.8 0.0 1.7 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.1 AIC15339.1 - 1.3e-05 25.1 0.1 2.4e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_11 PF08279.7 AIC15339.1 - 1.5e-05 24.5 0.0 4.1e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 HTH domain HTH_27 PF13463.1 AIC15339.1 - 0.00019 21.6 0.0 0.00034 20.8 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain B-block_TFIIIC PF04182.7 AIC15339.1 - 0.00086 19.1 0.0 0.0023 17.7 0.0 1.7 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_Crp_2 PF13545.1 AIC15339.1 - 0.0013 18.4 0.0 0.0027 17.4 0.0 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_12 PF08461.5 AIC15339.1 - 0.0031 17.2 0.1 0.0071 16.0 0.0 1.7 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain MarR PF01047.17 AIC15339.1 - 0.011 15.4 0.0 0.025 14.2 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_28 PF13518.1 AIC15339.1 - 0.012 15.6 0.0 0.03 14.3 0.0 1.7 1 1 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4 PF04545.11 AIC15339.1 - 0.024 13.9 0.0 0.13 11.6 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 TrmB PF01978.14 AIC15339.1 - 0.03 14.0 0.0 0.06 13.0 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_10 PF04967.7 AIC15339.1 - 0.033 13.7 0.0 0.12 11.9 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain DUF2513 PF10711.4 AIC15339.1 - 0.041 13.9 0.0 0.085 12.9 0.0 1.5 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) FaeA PF04703.7 AIC15339.1 - 0.042 14.0 0.0 0.091 12.9 0.0 1.6 1 0 0 1 1 1 0 FaeA-like protein HTH_36 PF13730.1 AIC15339.1 - 0.048 13.7 0.0 0.097 12.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Sigma70_r4_2 PF08281.7 AIC15339.1 - 0.051 13.0 0.0 0.26 10.7 0.0 2.1 3 0 0 3 3 2 0 Sigma-70, region 4 HTH_23 PF13384.1 AIC15339.1 - 0.081 12.6 0.0 0.3 10.7 0.0 2.0 1 1 0 1 1 1 0 Homeodomain-like domain Fe_dep_repress PF01325.14 AIC15339.1 - 0.087 12.7 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_IclR PF09339.5 AIC15339.1 - 0.14 11.7 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain Asn_synthase PF00733.16 AIC15341.1 - 3e-51 174.3 0.3 4.9e-51 173.6 0.2 1.4 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.1 AIC15341.1 - 1.9e-34 118.0 0.0 3.5e-34 117.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.1 AIC15341.1 - 4.3e-31 107.6 0.0 7.9e-31 106.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_2 PF00310.16 AIC15341.1 - 1.3e-13 50.4 0.4 8.4e-12 44.4 0.1 2.7 1 1 1 2 2 2 1 Glutamine amidotransferases class-II NAD_synthase PF02540.12 AIC15341.1 - 0.00023 20.1 0.0 0.0016 17.3 0.0 2.1 2 0 0 2 2 2 1 NAD synthase QueC PF06508.8 AIC15341.1 - 0.0039 16.4 0.0 0.0084 15.4 0.0 1.6 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.14 AIC15341.1 - 0.066 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DUF1961 PF09224.6 AIC15341.1 - 0.11 11.5 0.0 0.23 10.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1961) C1_1 PF00130.17 AIC15342.1 - 0.0028 17.3 2.4 0.0032 17.1 1.7 1.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Cytochrom_c3_2 PF14537.1 AIC15342.1 - 0.0035 17.6 1.2 0.0036 17.6 0.9 1.2 1 0 0 1 1 1 1 Cytochrome c3 Prok-RING_1 PF14446.1 AIC15342.1 - 0.0069 16.0 2.2 0.0083 15.8 1.6 1.1 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 HypA PF01155.14 AIC15342.1 - 0.008 15.8 1.7 0.0085 15.7 1.2 1.0 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family Spt4 PF06093.8 AIC15342.1 - 0.011 15.5 0.9 0.011 15.5 0.7 1.0 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger zf-dskA_traR PF01258.12 AIC15342.1 - 0.013 15.1 1.8 0.62 9.8 0.2 2.1 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zinc-ribbons_6 PF07191.7 AIC15342.1 - 0.035 13.8 1.5 0.038 13.7 1.0 1.1 1 0 0 1 1 1 0 zinc-ribbons Cytochrome_C7 PF14522.1 AIC15342.1 - 0.15 11.7 5.1 0.14 11.8 0.4 1.5 1 1 1 2 2 2 0 Cytochrome c7 Fer2_BFD PF04324.10 AIC15342.1 - 0.21 11.6 3.2 4.9 7.2 2.2 2.0 1 1 0 1 1 1 0 BFD-like [2Fe-2S] binding domain zf-trcl PF13451.1 AIC15342.1 - 0.22 11.2 2.4 6.7 6.4 0.2 2.1 2 0 0 2 2 2 0 Probable zinc-binding domain Laminin_EGF PF00053.19 AIC15342.1 - 0.34 10.8 4.2 1.3 9.0 2.9 1.8 1 1 0 1 1 1 0 Laminin EGF-like (Domains III and V) XPA_N PF01286.13 AIC15342.1 - 0.45 10.2 2.6 3.2 7.4 0.1 2.1 1 1 1 2 2 2 0 XPA protein N-terminal Fer4_4 PF12800.2 AIC15342.1 - 1.8 9.1 4.3 14 6.2 0.5 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain Paired_CXXCH_1 PF09699.5 AIC15342.1 - 1.9 8.0 6.6 0.65 9.5 0.6 2.1 1 1 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) YhfH PF14149.1 AIC15342.1 - 3 7.6 7.6 7.8 6.3 5.2 1.7 1 1 0 1 1 1 0 YhfH-like protein UvrB PF12344.3 AIC15343.1 - 4.2e-21 74.2 2.3 1.1e-20 72.8 1.6 1.8 1 0 0 1 1 1 1 Ultra-violet resistance protein B Helicase_C PF00271.26 AIC15343.1 - 2.9e-15 55.8 0.0 1.1e-14 54.0 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.10 AIC15343.1 - 2.8e-12 46.8 0.2 2e-11 44.0 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.24 AIC15343.1 - 1.9e-06 27.4 0.1 0.00017 21.1 0.0 3.3 3 0 0 3 3 3 1 DEAD/DEAH box helicase AAA_19 PF13245.1 AIC15343.1 - 0.00011 21.8 0.1 0.0033 17.1 0.0 2.7 2 0 0 2 2 2 1 Part of AAA domain Kinesin PF00225.18 AIC15343.1 - 0.0081 14.9 0.0 0.015 14.0 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain UB2H PF14814.1 AIC15343.1 - 0.03 14.0 0.0 0.16 11.6 0.0 2.3 2 0 0 2 2 2 0 Bifunctional transglycosylase second domain ABC_tran PF00005.22 AIC15343.1 - 0.074 13.3 0.1 0.28 11.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter UVR PF02151.14 AIC15343.1 - 0.19 11.2 13.5 0.019 14.4 4.4 3.0 2 0 0 2 2 2 0 UvrB/uvrC motif Tim44 PF04280.10 AIC15343.1 - 0.2 11.5 2.2 1.2 9.1 0.1 2.5 2 1 0 2 2 2 0 Tim44-like domain ABC_tran PF00005.22 AIC15344.1 - 1.7e-22 80.1 0.3 0.00017 21.8 0.0 4.6 4 0 0 4 4 4 4 ABC transporter SMC_N PF02463.14 AIC15344.1 - 2.2e-10 40.1 0.3 0.37 9.9 0.0 4.1 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 AIC15344.1 - 2.1e-09 37.7 8.3 0.0022 18.0 0.0 4.6 4 1 0 4 4 4 2 AAA domain AAA_29 PF13555.1 AIC15344.1 - 1.4e-08 34.1 0.2 0.0069 15.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_25 PF13481.1 AIC15344.1 - 2.2e-08 33.7 0.3 0.0017 17.8 0.1 3.1 3 1 0 3 3 2 2 AAA domain AAA_16 PF13191.1 AIC15344.1 - 3.8e-07 30.2 0.1 0.0061 16.5 0.0 3.0 3 0 0 3 3 2 2 AAA ATPase domain DUF258 PF03193.11 AIC15344.1 - 7.1e-07 28.5 0.1 0.014 14.5 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function, DUF258 AAA_33 PF13671.1 AIC15344.1 - 3.9e-06 26.7 0.8 0.16 11.8 0.0 3.9 4 0 0 4 4 4 2 AAA domain AAA_14 PF13173.1 AIC15344.1 - 6.2e-06 26.1 0.0 0.055 13.3 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_19 PF13245.1 AIC15344.1 - 1.7e-05 24.4 0.0 0.26 11.0 0.0 3.7 3 0 0 3 3 3 2 Part of AAA domain DnaJ_CXXCXGXG PF00684.14 AIC15344.1 - 2.5e-05 24.2 12.5 0.0044 17.0 0.4 4.5 3 1 1 4 4 4 1 DnaJ central domain AAA_17 PF13207.1 AIC15344.1 - 3.3e-05 24.7 6.2 0.089 13.6 0.4 4.1 5 0 0 5 5 3 2 AAA domain AAA_10 PF12846.2 AIC15344.1 - 4.1e-05 23.1 1.6 0.092 12.1 0.1 3.1 4 0 0 4 4 3 2 AAA-like domain AAA_18 PF13238.1 AIC15344.1 - 5.4e-05 23.4 0.6 0.36 11.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain NACHT PF05729.7 AIC15344.1 - 6.9e-05 22.5 0.0 0.089 12.4 0.0 2.7 3 0 0 3 3 2 2 NACHT domain AAA_22 PF13401.1 AIC15344.1 - 0.00041 20.4 5.8 0.68 10.0 0.0 4.4 5 1 0 5 5 5 2 AAA domain AAA_15 PF13175.1 AIC15344.1 - 0.0005 19.2 0.4 2.2 7.2 0.0 4.2 4 0 0 4 4 4 1 AAA ATPase domain APS_kinase PF01583.15 AIC15344.1 - 0.0005 19.7 0.8 0.28 10.8 0.0 2.9 3 0 0 3 3 3 1 Adenylylsulphate kinase AAA_23 PF13476.1 AIC15344.1 - 0.00052 20.4 10.1 0.0025 18.1 0.2 3.1 4 0 0 4 4 2 2 AAA domain MMR_HSR1 PF01926.18 AIC15344.1 - 0.00069 19.5 0.1 1.8 8.5 0.0 3.7 3 0 0 3 3 3 1 50S ribosome-binding GTPase FtsK_SpoIIIE PF01580.13 AIC15344.1 - 0.001 18.6 0.2 1.5 8.2 0.0 2.5 2 0 0 2 2 2 2 FtsK/SpoIIIE family KaiC PF06745.8 AIC15344.1 - 0.0012 17.9 0.1 0.73 8.8 0.0 2.8 2 0 0 2 2 2 1 KaiC T2SE PF00437.15 AIC15344.1 - 0.0012 17.7 0.1 1.1 8.0 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein Viral_helicase1 PF01443.13 AIC15344.1 - 0.0021 17.6 0.1 0.28 10.6 0.1 2.8 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase cobW PF02492.14 AIC15344.1 - 0.0022 17.4 0.9 0.46 9.9 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.4 AIC15344.1 - 0.0028 16.6 0.1 2.1 7.2 0.1 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.17 AIC15344.1 - 0.0033 16.3 0.8 5.2 5.8 0.0 3.3 3 0 0 3 3 3 0 NB-ARC domain MobB PF03205.9 AIC15344.1 - 0.0045 16.6 1.2 2.2 7.9 0.1 3.2 3 0 0 3 3 2 1 Molybdopterin guanine dinucleotide synthesis protein B DAP3 PF10236.4 AIC15344.1 - 0.0053 15.7 0.3 5.3 5.8 0.1 3.1 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 ArgK PF03308.11 AIC15344.1 - 0.0096 14.7 1.0 3.8 6.1 0.0 2.9 3 0 0 3 3 3 1 ArgK protein NTPase_1 PF03266.10 AIC15344.1 - 0.011 15.4 1.9 2.8 7.5 0.0 3.3 3 1 1 4 4 3 0 NTPase Arch_ATPase PF01637.13 AIC15344.1 - 0.012 15.2 1.6 2.3 7.8 0.0 3.2 3 0 0 3 3 3 0 Archaeal ATPase RNA_helicase PF00910.17 AIC15344.1 - 0.016 15.3 0.1 2.8 8.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 AIC15344.1 - 0.02 14.8 0.5 9.2 6.2 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_30 PF13604.1 AIC15344.1 - 0.022 14.3 0.2 9.7 5.7 0.0 3.0 3 0 0 3 3 3 0 AAA domain SbcCD_C PF13558.1 AIC15344.1 - 0.1 12.5 0.8 4.6 7.2 0.0 3.5 3 2 0 3 3 3 0 Putative exonuclease SbcCD, C subunit BCA_ABC_TP_C PF12399.3 AIC15344.1 - 0.18 11.5 4.1 0.21 11.3 0.1 2.6 3 0 0 3 3 2 0 Branched-chain amino acid ATP-binding cassette transporter DUF87 PF01935.12 AIC15344.1 - 2.1 8.1 7.5 5.9 6.6 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function DUF87 UvrC_HhH_N PF08459.6 AIC15345.1 - 7.5e-44 148.9 0.0 1.8e-43 147.7 0.0 1.7 1 0 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal GIY-YIG PF01541.19 AIC15345.1 - 2.2e-10 40.7 0.1 6.6e-10 39.2 0.1 1.8 1 0 0 1 1 1 1 GIY-YIG catalytic domain UVR PF02151.14 AIC15345.1 - 0.01 15.3 1.8 0.01 15.3 1.3 1.9 2 0 0 2 2 2 1 UvrB/uvrC motif DUF294 PF03445.8 AIC15346.1 - 0.099 12.2 0.7 0.11 12.1 0.5 1.1 1 0 0 1 1 1 0 Putative nucleotidyltransferase DUF294 AlaDh_PNT_N PF05222.10 AIC15348.1 - 1.7e-37 128.4 0.0 3e-37 127.6 0.0 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.16 AIC15348.1 - 4.2e-14 52.4 0.5 1.6e-12 47.3 0.4 2.3 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.9 AIC15348.1 - 4.3e-05 22.1 0.3 6e-05 21.6 0.2 1.1 1 0 0 1 1 1 1 HI0933-like protein Shikimate_DH PF01488.15 AIC15348.1 - 9.2e-05 22.5 0.1 0.00021 21.4 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.1 AIC15348.1 - 0.00023 21.3 0.2 0.00049 20.3 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_3 PF01494.14 AIC15348.1 - 0.0059 15.6 0.0 0.017 14.1 0.0 1.7 2 0 0 2 2 2 1 FAD binding domain ADH_zinc_N PF00107.21 AIC15348.1 - 0.0062 16.0 0.3 0.013 15.0 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 AIC15348.1 - 0.0081 15.3 0.1 0.016 14.3 0.1 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XdhC_C PF13478.1 AIC15348.1 - 0.05 13.9 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 XdhC Rossmann domain UDPG_MGDP_dh_C PF03720.10 AIC15348.1 - 0.058 13.5 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Pyr_redox PF00070.22 AIC15348.1 - 0.088 13.2 0.1 0.23 11.9 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.9 AIC15348.1 - 0.094 11.3 0.3 0.18 10.4 0.0 1.5 2 0 0 2 2 2 0 Tryptophan halogenase HypA PF01155.14 AIC15349.1 - 4.6 6.9 7.0 4.8 6.8 4.8 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Copper-bind PF00127.15 AIC15350.1 - 1.7e-10 41.0 0.0 2.3e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC15350.1 - 5.9e-05 22.9 0.0 0.00018 21.3 0.0 1.8 1 1 0 1 1 1 1 Cupredoxin-like domain Peptidase_M23 PF01551.17 AIC15353.1 - 8.3e-09 35.3 0.6 1.7e-07 31.2 0.3 2.4 2 0 0 2 2 2 1 Peptidase family M23 Cupredoxin_1 PF13473.1 AIC15354.1 - 3.2e-13 49.4 0.0 5.6e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 AIC15354.1 - 1e-09 38.4 0.2 8.9e-09 35.4 0.1 2.1 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family DUF4480 PF13715.1 AIC15354.1 - 0.044 13.8 0.1 0.073 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4480) HTH_45 PF14947.1 AIC15355.1 - 1e-05 25.2 0.0 1.2e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.17 AIC15355.1 - 0.0077 15.9 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 MarR family PrgI PF12666.2 AIC15356.1 - 0.0088 16.1 0.6 0.012 15.6 0.4 1.2 1 0 0 1 1 1 1 PrgI family protein DUF3754 PF12576.3 AIC15356.1 - 0.016 14.8 0.1 0.02 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3754) DUF2721 PF11026.3 AIC15356.1 - 0.027 14.0 1.2 0.068 12.8 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) DUF2852 PF11014.3 AIC15356.1 - 0.03 14.2 4.4 2.9 7.8 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) Brr6_like_C_C PF10104.4 AIC15356.1 - 0.036 13.5 0.8 0.078 12.4 0.2 1.7 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain DUF2207 PF09972.4 AIC15356.1 - 0.041 12.4 0.0 0.041 12.4 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Mtp PF03821.11 AIC15356.1 - 0.099 12.0 0.1 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Golgi 4-transmembrane spanning transporter DUF1049 PF06305.6 AIC15356.1 - 0.12 11.8 0.7 0.2 11.1 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) DUF805 PF05656.9 AIC15356.1 - 0.37 10.6 3.0 0.52 10.1 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF805) CbiQ PF02361.11 AIC15356.1 - 6.2 6.3 7.6 42 3.5 5.3 1.9 1 1 0 1 1 1 0 Cobalt transport protein PIG-Y PF15159.1 AIC15356.1 - 7.1 6.9 7.0 1.3e+02 2.8 4.8 2.2 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y Tetraspannin PF00335.15 AIC15357.1 - 0.11 11.7 3.2 0.042 13.1 0.8 1.5 2 0 0 2 2 2 0 Tetraspanin family DUF4267 PF14087.1 AIC15357.1 - 0.16 11.5 4.1 0.23 11.0 2.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4267) SnoaL_2 PF12680.2 AIC15358.1 - 0.33 11.3 2.7 3.5 8.0 1.9 2.0 1 1 0 1 1 1 0 SnoaL-like domain Radical_SAM PF04055.16 AIC15359.1 - 4.6e-15 56.1 0.0 8.4e-15 55.3 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Radical_SAM PF04055.16 AIC15360.1 - 5.7e-10 39.6 0.0 1.2e-09 38.5 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily BATS PF06968.8 AIC15360.1 - 0.13 12.0 0.0 0.36 10.6 0.0 1.7 1 0 0 1 1 1 0 Biotin and Thiamin Synthesis associated domain Trypsin_2 PF13365.1 AIC15361.1 - 4e-18 65.5 0.0 7.5e-18 64.6 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.1 AIC15361.1 - 2.3e-15 56.2 3.1 3.3e-14 52.5 1.0 2.7 2 1 0 2 2 2 1 PDZ domain Trypsin PF00089.21 AIC15361.1 - 7.4e-13 48.5 0.0 1.3e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Trypsin PDZ PF00595.19 AIC15361.1 - 0.0036 17.4 1.4 0.2 11.8 0.0 3.3 3 0 0 3 3 3 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S29 PF02907.10 AIC15361.1 - 0.041 13.4 0.0 0.091 12.2 0.0 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Peptidase_S46 PF10459.4 AIC15361.1 - 0.37 9.1 1.3 0.68 8.2 0.1 1.7 2 0 0 2 2 2 0 Peptidase S46 HTH_45 PF14947.1 AIC15362.1 - 3.5e-18 65.1 0.2 4.1e-18 64.9 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_27 PF13463.1 AIC15362.1 - 0.00023 21.4 0.0 0.00039 20.6 0.0 1.5 2 0 0 2 2 2 1 Winged helix DNA-binding domain DUF4364 PF14277.1 AIC15362.1 - 0.0009 18.8 0.1 0.0011 18.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_IclR PF09339.5 AIC15362.1 - 0.071 12.7 0.1 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_24 PF13412.1 AIC15362.1 - 0.14 11.5 0.0 0.23 10.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Glycos_transf_2 PF00535.21 AIC15363.1 - 7.7e-31 107.0 0.0 1.1e-30 106.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AIC15363.1 - 2e-22 80.1 0.0 3e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 AIC15363.1 - 8.9e-14 51.1 0.0 2e-13 49.9 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 AIC15363.1 - 2.2e-08 33.5 0.0 2.9e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 AIC15363.1 - 0.00011 22.3 0.0 0.0002 21.6 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Polyketide_cyc2 PF10604.4 AIC15364.1 - 1.5e-13 51.0 0.0 1.7e-13 50.9 0.0 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 AIC15364.1 - 4.6e-08 33.1 0.0 6.5e-08 32.6 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.8 AIC15364.1 - 0.00097 18.8 0.1 0.0018 17.9 0.1 1.4 1 1 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) DUF2310 PF10071.4 AIC15364.1 - 0.16 10.9 0.0 0.19 10.6 0.0 1.1 1 0 0 1 1 1 0 Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310) CbtA PF09490.5 AIC15365.1 - 1.6e-19 70.1 12.5 2.2e-19 69.6 8.7 1.1 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) Acyl_transf_3 PF01757.17 AIC15365.1 - 0.49 9.1 9.2 0.92 8.2 1.8 2.2 1 1 1 2 2 2 0 Acyltransferase family 7TM-7TMR_HD PF07698.6 AIC15365.1 - 2.6 7.4 11.8 0.17 11.2 0.8 2.9 2 1 1 3 3 3 0 7TM receptor with intracellular HD hydrolase ATP_synt_H PF05493.8 AIC15365.1 - 6.7 6.8 6.6 21 5.2 0.0 3.2 3 1 1 4 4 4 0 ATP synthase subunit H CbtB PF09489.5 AIC15366.1 - 1.1e-06 28.4 6.7 9.2e-06 25.4 0.9 2.1 2 0 0 2 2 2 2 Probable cobalt transporter subunit (CbtB) DUF4443 PF14544.1 AIC15367.1 - 1.2e-07 31.5 0.0 1.9e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4443) Ribosomal_S19e PF01090.14 AIC15367.1 - 0.025 13.9 0.0 0.052 12.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein S19e MarR_2 PF12802.2 AIC15367.1 - 0.054 13.1 0.0 0.13 11.9 0.0 1.6 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.1 AIC15367.1 - 0.056 12.8 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding FeoC PF09012.5 AIC15367.1 - 0.058 13.1 0.2 0.19 11.4 0.1 1.8 2 0 0 2 2 2 0 FeoC like transcriptional regulator Yae1_N PF09811.4 AIC15368.1 - 0.99 8.9 7.5 19 4.8 0.2 3.1 2 1 1 3 3 3 0 Essential protein Yae1, N terminal Guanylate_cyc PF00211.15 AIC15370.1 - 2.2e-16 59.7 0.0 2.8e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain CBS PF00571.23 AIC15371.1 - 1.1e-24 85.9 0.3 1.6e-14 53.3 0.0 2.1 2 0 0 2 2 2 2 CBS domain RDD PF06271.7 AIC15372.1 - 5.8e-21 74.8 5.2 6.7e-21 74.6 3.6 1.1 1 0 0 1 1 1 1 RDD family F5_F8_type_C PF00754.20 AIC15373.1 - 3.5e-18 65.6 0.2 5.7e-18 64.9 0.1 1.3 1 0 0 1 1 1 1 F5/8 type C domain LysM PF01476.15 AIC15373.1 - 1.8e-11 43.7 0.0 2.8e-11 43.1 0.0 1.3 1 0 0 1 1 1 1 LysM domain 3D PF06725.6 AIC15373.1 - 4e-05 23.5 0.0 0.0001 22.2 0.0 1.7 1 0 0 1 1 1 1 3D domain HTH_27 PF13463.1 AIC15374.1 - 0.016 15.5 1.9 0.15 12.4 0.1 2.4 3 0 0 3 3 3 0 Winged helix DNA-binding domain Fibritin_C PF07921.7 AIC15374.1 - 0.017 15.0 0.0 0.023 14.6 0.0 1.4 1 0 0 1 1 1 0 Fibritin C-terminal region ACCA PF03255.9 AIC15374.1 - 0.086 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit zf-CHCC PF10276.4 AIC15377.1 - 0.067 13.0 0.5 0.15 11.9 0.1 1.8 2 0 0 2 2 2 0 Zinc-finger domain DUF640 PF04852.7 AIC15377.1 - 3.5 7.8 5.1 1.6 8.9 1.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF640) Type_III_YscX PF09474.5 AIC15380.1 - 0.014 15.4 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) DUF624 PF04854.9 AIC15380.1 - 0.016 15.0 0.4 0.69 9.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF624 DUF4250 PF14056.1 AIC15380.1 - 0.04 13.6 0.0 11 5.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) Annexin PF00191.15 AIC15380.1 - 0.069 13.0 0.2 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Annexin Radical_SAM PF04055.16 AIC15380.1 - 0.099 12.8 0.5 0.77 9.9 0.3 2.0 1 1 0 1 1 1 0 Radical SAM superfamily TENA_THI-4 PF03070.11 AIC15381.1 - 2e-16 60.4 0.8 2.4e-16 60.1 0.5 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Haem_oxygenas_2 PF14518.1 AIC15381.1 - 1.1e-13 51.2 0.5 3.7e-10 39.8 0.1 2.2 1 1 1 2 2 2 2 Iron-containing redox enzyme GAD PF02938.9 AIC15381.1 - 0.08 13.1 0.1 0.25 11.5 0.0 1.9 2 0 0 2 2 2 0 GAD domain Glyco_hydro_42M PF08532.5 AIC15382.1 - 0.12 11.4 0.0 0.88 8.6 0.0 1.9 1 1 0 1 1 1 0 Beta-galactosidase trimerisation domain HTH_45 PF14947.1 AIC15383.1 - 3.8e-20 71.4 0.1 4.9e-20 71.1 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC15383.1 - 0.00053 19.6 0.0 0.00074 19.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) Pol_alpha_B_N PF08418.5 AIC15385.1 - 0.0074 15.8 0.1 0.0074 15.8 0.1 1.0 1 0 0 1 1 1 1 DNA polymerase alpha subunit B N-terminal DUF3567 PF12091.3 AIC15385.1 - 0.12 12.3 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3567) AmoC PF04896.7 AIC15387.1 - 3.9e-15 55.5 4.8 4.8e-15 55.2 3.3 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C OAD_gamma PF04277.8 AIC15387.1 - 0.35 11.2 1.8 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain polyprenyl_synt PF00348.12 AIC15388.1 - 2.4e-44 151.1 0.0 3.2e-44 150.7 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Oxidored_q1 PF00361.15 AIC15389.1 - 9.1e-59 198.9 17.1 9.1e-59 198.9 11.8 2.6 2 1 1 3 3 3 1 NADH-Ubiquinone/plastoquinone (complex I), various chains DUF2108 PF09881.4 AIC15389.1 - 0.28 11.0 10.5 0.041 13.7 3.3 2.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2108) Oxidored_q1 PF00361.15 AIC15390.1 - 4.7e-60 203.1 29.0 1.1e-54 185.5 14.6 3.1 3 0 0 3 3 3 2 NADH-Ubiquinone/plastoquinone (complex I), various chains Oxidored_q1_N PF00662.15 AIC15390.1 - 7.5e-08 31.8 1.0 3.3e-07 29.7 0.7 2.1 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidored_q1_C PF01010.14 AIC15390.1 - 0.00025 20.6 0.1 0.00044 19.8 0.0 1.4 1 0 0 1 1 1 1 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus Ca_hom_mod PF14798.1 AIC15390.1 - 0.92 8.4 5.9 0.41 9.5 1.1 2.4 3 0 0 3 3 3 0 Calcium homeostasis modulator Oxidored_q1 PF00361.15 AIC15391.1 - 3.5e-63 213.4 26.5 3.5e-63 213.4 18.4 2.3 3 0 0 3 3 3 1 NADH-Ubiquinone/plastoquinone (complex I), various chains DUF3272 PF11676.3 AIC15391.1 - 5.7 7.0 13.7 5.4 7.1 4.2 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3272) Oxidored_q2 PF00420.19 AIC15392.1 - 4.2e-24 83.9 4.7 4.6e-24 83.8 3.3 1.0 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L Oxidored_q1_C PF01010.14 AIC15392.1 - 0.065 12.7 1.2 0.071 12.6 0.8 1.1 1 0 0 1 1 1 0 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus DUF2108 PF09881.4 AIC15392.1 - 3.3 7.5 9.2 0.68 9.8 2.4 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2108) BphX PF06139.7 AIC15392.1 - 3.5 7.2 8.0 8.8 5.9 5.6 1.6 1 1 0 1 1 1 0 BphX-like DUF3098 PF11297.3 AIC15392.1 - 8.6 6.1 10.9 0.75 9.5 3.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3098) Oxidored_q3 PF00499.15 AIC15393.1 - 3.1e-19 69.1 12.5 4e-19 68.8 8.7 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4040 PF13244.1 AIC15393.1 - 0.0017 18.3 13.5 0.0017 18.3 9.4 2.1 3 0 0 3 3 3 1 Domain of unknown function (DUF4040) TMEM171 PF15471.1 AIC15393.1 - 0.01 14.6 0.5 0.018 13.8 0.0 1.6 1 1 1 2 2 2 0 Transmembrane protein family 171 IncA PF04156.9 AIC15393.1 - 0.68 9.5 0.0 0.68 9.5 0.0 3.7 2 1 2 4 4 4 0 IncA protein Fer4 PF00037.22 AIC15394.1 - 3.4e-13 48.5 11.0 2.7e-09 36.2 1.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 AIC15394.1 - 5.9e-10 39.3 8.5 1e-09 38.6 5.9 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 AIC15394.1 - 4.1e-09 36.1 7.5 7.5e-09 35.2 5.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.1 AIC15394.1 - 1.9e-08 34.0 20.5 1.2e-06 28.2 7.1 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 AIC15394.1 - 2.9e-08 33.1 11.9 6.9e-05 22.5 1.7 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.2 AIC15394.1 - 1.5e-07 30.9 12.2 5.2e-06 26.0 1.2 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.1 AIC15394.1 - 5.3e-07 29.7 9.3 2.3e-06 27.7 6.9 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.2 AIC15394.1 - 1e-06 28.5 8.3 0.0023 18.1 0.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 AIC15394.1 - 1.7e-06 27.9 16.7 8.9e-05 22.4 6.1 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.1 AIC15394.1 - 3.7e-06 27.5 7.3 6.7e-06 26.7 5.1 1.5 1 0 0 1 1 1 1 4Fe-4S double cluster binding domain Fer4_17 PF13534.1 AIC15394.1 - 8.7e-06 25.9 6.4 0.0062 16.8 0.1 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_15 PF13459.1 AIC15394.1 - 4.7e-05 23.8 3.6 0.072 13.6 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_18 PF13746.1 AIC15394.1 - 0.0046 17.3 12.4 0.0068 16.8 0.9 2.3 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_3 PF12798.2 AIC15394.1 - 0.0058 17.1 4.0 0.0058 17.1 2.8 2.2 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_13 PF13370.1 AIC15394.1 - 0.018 15.4 8.4 0.19 12.1 0.1 2.3 2 0 0 2 2 2 0 4Fe-4S single cluster domain NADHdh PF00146.16 AIC15395.1 - 1.1e-75 254.6 18.0 1.6e-75 254.0 12.5 1.2 1 0 0 1 1 1 1 NADH dehydrogenase Complex1_49kDa PF00346.14 AIC15396.1 - 4.6e-63 212.7 0.0 5.4e-49 166.6 0.0 2.1 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Csm1 PF12539.3 AIC15396.1 - 0.013 15.9 0.0 0.51 10.8 0.0 2.5 1 1 1 2 2 2 0 Chromosome segregation protein Csm1/Pcs1 Complex1_30kDa PF00329.14 AIC15397.1 - 8.6e-29 99.8 0.0 1.2e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit HpaP PF09483.5 AIC15397.1 - 0.29 11.0 15.9 0.43 10.5 11.0 1.2 1 0 0 1 1 1 0 Type III secretion protein (HpaP) FAP PF07174.6 AIC15397.1 - 9.6 5.4 27.6 12 5.0 19.2 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) Oxidored_q6 PF01058.17 AIC15398.1 - 4.4e-24 84.5 0.4 6.3e-24 84.0 0.3 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Oxidored_q4 PF00507.14 AIC15399.1 - 1.4e-14 53.7 2.2 1.7e-14 53.4 1.5 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 DUF4367 PF14285.1 AIC15400.1 - 0.0026 17.0 2.0 0.035 13.4 1.4 2.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4367) DUF4307 PF14155.1 AIC15400.1 - 0.11 12.2 0.1 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) FAD_oxidored PF12831.2 AIC15403.1 - 2.4e-17 63.1 0.1 2.9e-17 62.8 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.19 AIC15403.1 - 2.3e-12 46.4 6.3 1e-07 31.2 1.6 2.2 1 1 0 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.7 AIC15403.1 - 3.5e-10 39.3 0.0 4.4e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein HI0933_like PF03486.9 AIC15403.1 - 2e-08 33.1 0.9 3e-08 32.5 0.3 1.5 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_3 PF01494.14 AIC15403.1 - 3.4e-08 32.9 0.2 1.9e-07 30.5 0.1 2.0 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 AIC15403.1 - 1.1e-07 31.9 0.1 1.8e-07 31.2 0.0 1.4 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.19 AIC15403.1 - 2.8e-07 29.7 4.9 3.2e-07 29.5 1.7 1.9 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.17 AIC15403.1 - 4.2e-07 29.1 1.1 6.1e-07 28.6 0.8 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A NAD_binding_8 PF13450.1 AIC15403.1 - 6e-07 29.4 0.2 1.5e-06 28.1 0.2 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.9 AIC15403.1 - 2.1e-06 26.6 1.2 0.033 12.8 0.4 2.4 1 1 1 2 2 2 2 Tryptophan halogenase Pyr_redox_3 PF13738.1 AIC15403.1 - 9.6e-06 25.7 0.1 1.7e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.12 AIC15403.1 - 3.3e-05 23.0 0.6 0.00017 20.7 0.1 2.0 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.16 AIC15403.1 - 0.00031 20.3 0.0 0.0005 19.6 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 AIC15403.1 - 0.0011 19.3 0.3 0.0026 18.1 0.0 1.8 2 0 0 2 2 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.13 AIC15403.1 - 0.0033 17.1 0.9 0.022 14.3 0.2 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PA PF02225.17 AIC15403.1 - 0.03 14.0 0.6 3.6 7.3 0.1 2.5 2 0 0 2 2 2 0 PA domain NAD_binding_7 PF13241.1 AIC15403.1 - 0.083 13.1 0.1 0.2 11.9 0.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding NAD_Gly3P_dh_N PF01210.18 AIC15403.1 - 0.17 11.6 0.7 0.41 10.3 0.2 1.8 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PmbA_TldD PF01523.11 AIC15404.1 - 9.6e-62 208.8 7.7 1.2e-61 208.5 5.3 1.1 1 0 0 1 1 1 1 Putative modulator of DNA gyrase PmbA_TldD PF01523.11 AIC15405.1 - 3.7e-65 220.1 6.4 6.3e-65 219.3 4.4 1.4 1 0 0 1 1 1 1 Putative modulator of DNA gyrase GSDH PF07995.6 AIC15406.1 - 6.8e-49 166.7 0.0 1.1e-48 165.9 0.0 1.3 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Tachylectin PF14517.1 AIC15406.1 - 0.008 15.5 0.0 3.6 6.8 0.0 2.4 2 0 0 2 2 2 2 Tachylectin Cupin_2 PF07883.6 AIC15407.1 - 8.7e-09 34.7 0.6 1.2e-07 31.1 0.4 2.1 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.17 AIC15407.1 - 1.7e-07 30.7 0.0 2.2e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Cupin Auxin_BP PF02041.11 AIC15407.1 - 0.0001 21.7 0.0 0.00012 21.5 0.0 1.2 1 0 0 1 1 1 1 Auxin binding protein ARD PF03079.9 AIC15407.1 - 0.0063 16.4 0.1 0.0085 16.0 0.0 1.3 1 0 0 1 1 1 1 ARD/ARD' family AraC_binding PF02311.14 AIC15407.1 - 0.028 14.0 0.3 0.051 13.2 0.2 1.4 1 1 0 1 1 1 0 AraC-like ligand binding domain adh_short PF00106.20 AIC15408.1 - 3.9e-36 124.4 0.5 4.8e-36 124.1 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AIC15408.1 - 1.2e-20 74.3 0.1 1.4e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AIC15408.1 - 9.9e-13 48.1 0.5 1.3e-12 47.7 0.4 1.1 1 0 0 1 1 1 1 KR domain Saccharop_dh PF03435.13 AIC15408.1 - 0.00029 19.9 0.8 0.0004 19.4 0.6 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase THF_DHG_CYH_C PF02882.14 AIC15408.1 - 0.026 13.5 0.5 0.049 12.7 0.3 1.6 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.14 AIC15408.1 - 0.043 12.9 0.3 0.33 10.0 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF1776 PF08643.5 AIC15408.1 - 0.045 12.8 0.0 0.11 11.5 0.0 1.7 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.16 AIC15408.1 - 0.071 12.5 0.0 0.091 12.1 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 AIC15408.1 - 0.079 13.0 0.2 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_binding_3 PF01494.14 AIC15408.1 - 0.11 11.5 0.1 0.17 10.8 0.0 1.4 2 0 0 2 2 2 0 FAD binding domain AhpC-TSA PF00578.16 AIC15409.1 - 1.2e-11 44.3 0.0 1.9e-11 43.7 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AIC15409.1 - 1.3e-08 34.5 0.0 2e-08 33.9 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.1 AIC15409.1 - 6.2e-08 32.6 0.1 1.5e-07 31.4 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.1 AIC15409.1 - 0.062 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain GSHPx PF00255.14 AIC15409.1 - 0.11 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Glutathione peroxidase SelP_N PF04592.9 AIC15409.1 - 0.13 11.5 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AhpC-TSA PF00578.16 AIC15410.1 - 2.5e-40 136.9 0.0 3.2e-40 136.6 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AIC15410.1 - 2.9e-25 88.4 0.0 3.5e-25 88.2 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.1 AIC15410.1 - 7.9e-07 28.9 0.0 1.7e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF899 PF05988.7 AIC15410.1 - 0.00063 19.2 0.0 0.00068 19.1 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) SCO1-SenC PF02630.9 AIC15410.1 - 0.0057 16.2 0.1 0.062 12.9 0.1 2.0 1 1 0 1 1 1 1 SCO1/SenC Rubrerythrin PF02915.12 AIC15411.1 - 0.00062 20.0 1.9 0.0034 17.6 1.3 2.0 1 1 0 1 1 1 1 Rubrerythrin Ferritin PF00210.19 AIC15411.1 - 0.0063 16.2 4.4 0.041 13.6 2.9 2.0 1 1 0 1 1 1 1 Ferritin-like domain DUF2383 PF09537.5 AIC15411.1 - 0.0076 16.4 1.2 0.096 12.9 0.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF2383) DUF892 PF05974.7 AIC15411.1 - 0.19 11.5 3.7 0.84 9.4 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF892) MgtE_N PF03448.12 AIC15411.1 - 0.61 10.4 4.4 3.7 7.9 0.4 2.4 2 1 0 2 2 2 0 MgtE intracellular N domain RNA_pol_N PF01194.12 AIC15412.1 - 1.1e-28 98.9 0.6 1.5e-28 98.6 0.4 1.2 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Enolase_C PF00113.17 AIC15413.1 - 6e-60 202.7 0.0 8.1e-60 202.2 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.11 AIC15413.1 - 2.8e-30 104.9 0.1 5.9e-30 103.9 0.1 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE PF01188.16 AIC15413.1 - 0.00036 21.0 0.0 0.01 16.3 0.0 2.8 2 1 0 2 2 2 1 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MR_MLE_C PF13378.1 AIC15413.1 - 0.005 16.8 0.1 0.0096 15.8 0.1 1.5 1 0 0 1 1 1 1 Enolase C-terminal domain-like 5_3_exonuc_N PF02739.11 AIC15413.1 - 0.011 15.1 0.0 0.028 13.8 0.0 1.6 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain Ribosomal_S2 PF00318.15 AIC15414.1 - 1.5e-33 115.8 0.0 8.3e-30 103.5 0.0 2.1 1 1 0 1 1 1 1 Ribosomal protein S2 Peripla_BP_4 PF13407.1 AIC15414.1 - 0.021 14.1 0.3 0.031 13.6 0.2 1.3 1 0 0 1 1 1 0 Periplasmic binding protein domain Prismane PF03063.15 AIC15415.1 - 0.14 10.4 0.0 0.15 10.4 0.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family MEDS PF14417.1 AIC15416.1 - 0.0034 16.4 0.0 0.0053 15.8 0.0 1.3 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Abi_C PF14355.1 AIC15416.1 - 0.049 13.5 0.7 11 6.0 0.0 3.0 2 1 1 3 3 3 0 Abortive infection C-terminus Imm16 PF15565.1 AIC15416.1 - 0.13 12.1 0.0 1.9 8.3 0.0 2.4 2 1 1 3 3 3 0 Immunity protein 16 Memo PF01875.12 AIC15417.1 - 6.6e-76 254.7 0.0 7.7e-76 254.5 0.0 1.0 1 0 0 1 1 1 1 Memo-like protein LigB PF02900.13 AIC15417.1 - 0.0012 17.9 0.0 0.0022 17.0 0.0 1.4 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase GHMP_kinases_C PF08544.8 AIC15418.1 - 1.2e-17 63.8 1.7 1.2e-17 63.8 1.2 2.5 4 0 0 4 4 4 1 GHMP kinases C terminal GHMP_kinases_N PF00288.21 AIC15418.1 - 1.4e-17 63.5 0.6 1.4e-17 63.5 0.4 2.1 2 0 0 2 2 2 1 GHMP kinases N terminal domain PhoU PF01895.14 AIC15419.1 - 4.2e-17 62.3 5.4 1.7e-09 37.9 1.5 2.4 2 0 0 2 2 2 2 PhoU domain Antitoxin-MazE PF04014.13 AIC15419.1 - 0.00029 20.4 0.2 0.00076 19.1 0.1 1.8 1 1 0 1 1 1 1 Antidote-toxin recognition MazE GHMP_kinases_N PF00288.21 AIC15420.1 - 3.6e-10 39.7 1.3 7.1e-10 38.8 0.9 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain HHH_5 PF14520.1 AIC15420.1 - 0.055 13.6 0.0 0.27 11.4 0.0 2.2 1 1 0 1 1 1 0 Helix-hairpin-helix domain DUF137 PF02006.11 AIC15421.1 - 5.4e-75 250.6 0.4 7.2e-75 250.2 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF137 Pantoate_transf PF02548.10 AIC15422.1 - 8.9e-111 369.1 0.6 1e-110 368.9 0.4 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.1 AIC15422.1 - 5e-05 22.6 0.8 0.0004 19.6 0.6 2.3 1 1 0 1 1 1 1 Phosphoenolpyruvate phosphomutase DFP PF04127.10 AIC15423.1 - 1.5e-56 190.9 7.7 9.3e-56 188.3 2.9 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Flavoprotein PF02441.14 AIC15423.1 - 4.7e-29 100.6 0.6 4.7e-29 100.6 0.4 2.0 2 1 0 2 2 2 1 Flavoprotein YjeF_N PF03853.10 AIC15423.1 - 7.7e-05 22.3 2.0 0.15 11.6 0.1 3.6 3 1 1 4 4 4 2 YjeF-related protein N-terminus CPSase_L_chain PF00289.17 AIC15423.1 - 0.038 14.1 1.4 11 6.1 0.1 3.8 4 0 0 4 4 4 0 Carbamoyl-phosphate synthase L chain, N-terminal domain PrcB_C PF14343.1 AIC15424.1 - 0.013 15.2 0.3 0.054 13.1 0.0 2.1 2 0 0 2 2 2 0 PrcB C-terminal GbpC PF08363.5 AIC15424.1 - 0.1 11.8 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 Glucan-binding protein C Peptidase_M24 PF00557.19 AIC15425.1 - 7.6e-55 185.7 0.2 1e-54 185.2 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.13 AIC15425.1 - 3.3e-09 37.3 0.0 7.2e-09 36.2 0.0 1.7 1 0 0 1 1 1 1 Creatinase/Prolidase N-terminal domain URO-D PF01208.12 AIC15425.1 - 0.044 12.6 0.0 0.1 11.5 0.0 1.5 1 0 0 1 1 1 0 Uroporphyrinogen decarboxylase (URO-D) AAA PF00004.24 AIC15426.1 - 6.5e-98 324.0 0.0 3.6e-48 163.0 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 AIC15426.1 - 4.5e-21 74.5 0.4 1.3e-20 73.0 0.3 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.7 AIC15426.1 - 6e-15 54.9 0.1 6.5e-08 31.9 0.0 2.9 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 AIC15426.1 - 2.2e-14 53.7 0.2 9.3e-05 22.5 0.1 4.4 2 2 0 2 2 2 2 AAA domain AAA_2 PF07724.9 AIC15426.1 - 2.4e-14 53.5 0.0 9.6e-06 25.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.12 AIC15426.1 - 7.9e-14 51.0 0.1 2.1e-13 49.6 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.1 AIC15426.1 - 8.4e-14 51.9 0.6 1.5e-05 25.0 0.0 4.2 4 1 1 5 5 5 2 AAA ATPase domain AAA_17 PF13207.1 AIC15426.1 - 7.8e-13 49.2 0.0 1.2e-05 26.1 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.1 AIC15426.1 - 1.4e-10 41.1 0.0 0.00034 20.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 AIC15426.1 - 1.6e-10 40.8 0.9 0.0014 18.3 0.1 4.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 AIC15426.1 - 1.9e-10 40.1 0.0 0.00038 19.6 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_33 PF13671.1 AIC15426.1 - 2.4e-10 40.4 0.0 2.9e-05 23.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AIC15426.1 - 1.6e-09 37.3 0.7 0.0011 18.7 0.1 2.9 2 0 0 2 2 2 2 Part of AAA domain TIP49 PF06068.8 AIC15426.1 - 7.9e-09 34.7 0.0 0.0021 16.8 0.0 2.4 2 0 0 2 2 2 2 TIP49 C-terminus IstB_IS21 PF01695.12 AIC15426.1 - 2.2e-08 33.7 0.1 0.0023 17.3 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.1 AIC15426.1 - 2.5e-08 34.2 0.5 0.0048 17.2 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_25 PF13481.1 AIC15426.1 - 1.4e-07 31.1 5.1 0.36 10.1 0.0 4.9 4 1 0 5 5 5 3 AAA domain Arch_ATPase PF01637.13 AIC15426.1 - 3.1e-07 30.3 0.0 0.011 15.4 0.0 3.1 2 1 1 3 3 3 2 Archaeal ATPase AAA_28 PF13521.1 AIC15426.1 - 1.9e-06 27.9 0.0 0.0059 16.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.17 AIC15426.1 - 1.9e-06 27.9 0.1 0.059 13.5 0.0 2.9 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.16 AIC15426.1 - 2.5e-06 26.8 0.7 0.051 12.7 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI PhoH PF02562.11 AIC15426.1 - 6.5e-06 25.5 0.4 0.079 12.1 0.0 2.9 3 0 0 3 3 3 2 PhoH-like protein NB-ARC PF00931.17 AIC15426.1 - 8.1e-06 24.8 0.0 0.037 12.9 0.0 2.6 3 0 0 3 3 2 2 NB-ARC domain Sigma54_activat PF00158.21 AIC15426.1 - 1.4e-05 24.6 0.1 0.39 10.1 0.0 3.7 3 1 0 3 3 3 2 Sigma-54 interaction domain NACHT PF05729.7 AIC15426.1 - 1.6e-05 24.6 0.1 0.13 11.9 0.0 3.7 4 0 0 4 4 4 1 NACHT domain AAA_24 PF13479.1 AIC15426.1 - 2.7e-05 23.8 0.6 0.032 13.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.4 AIC15426.1 - 6.4e-05 22.0 0.0 0.082 11.8 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.6 AIC15426.1 - 6.5e-05 22.5 0.0 0.24 11.0 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.1 AIC15426.1 - 8.4e-05 22.2 0.3 0.38 10.3 0.0 3.4 3 0 0 3 3 3 1 AAA domain NTPase_1 PF03266.10 AIC15426.1 - 0.00013 21.7 0.2 0.39 10.4 0.0 3.3 2 1 1 3 3 3 1 NTPase DUF815 PF05673.8 AIC15426.1 - 0.00014 20.9 0.0 0.18 10.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ABC_tran PF00005.22 AIC15426.1 - 0.00015 22.0 0.0 0.37 11.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter Sigma54_activ_2 PF14532.1 AIC15426.1 - 0.00017 21.6 0.0 0.71 9.9 0.0 2.7 2 0 0 2 2 2 2 Sigma-54 interaction domain KaiC PF06745.8 AIC15426.1 - 0.00033 19.8 0.5 1.6 7.8 0.0 3.4 2 1 1 3 3 3 1 KaiC AAA_11 PF13086.1 AIC15426.1 - 0.00068 19.2 0.0 0.63 9.5 0.0 2.5 2 1 0 2 2 2 1 AAA domain Bac_DnaA PF00308.13 AIC15426.1 - 0.0012 18.5 0.0 2.8 7.5 0.0 3.1 3 0 0 3 3 3 0 Bacterial dnaA protein Parvo_NS1 PF01057.12 AIC15426.1 - 0.0013 17.7 0.1 0.98 8.2 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AFG1_ATPase PF03969.11 AIC15426.1 - 0.0021 16.9 0.0 1.7 7.3 0.0 2.5 2 0 0 2 2 2 2 AFG1-like ATPase T2SE PF00437.15 AIC15426.1 - 0.0051 15.7 0.0 2.7 6.8 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein Viral_helicase1 PF01443.13 AIC15426.1 - 0.0067 15.9 0.0 0.97 8.9 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UPF0079 PF02367.12 AIC15426.1 - 0.007 15.9 0.0 2.4 7.7 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 ATP-synt_ab PF00006.20 AIC15426.1 - 0.0073 15.8 0.0 2.1 7.7 0.0 2.5 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain ResIII PF04851.10 AIC15426.1 - 0.009 15.8 0.0 6.7 6.4 0.0 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit SKI PF01202.17 AIC15426.1 - 0.0095 15.8 0.0 5.6 6.8 0.0 2.5 2 0 0 2 2 2 0 Shikimate kinase Cytidylate_kin2 PF13189.1 AIC15426.1 - 0.023 14.6 0.5 0.14 12.0 0.0 2.5 4 0 0 4 4 2 0 Cytidylate kinase-like family Guanylate_kin PF00625.16 AIC15426.1 - 0.047 13.1 0.2 7.5 5.9 0.0 3.5 3 1 1 4 4 3 0 Guanylate kinase KAP_NTPase PF07693.9 AIC15426.1 - 0.056 12.4 0.0 7.6 5.4 0.0 2.7 2 1 1 3 3 3 0 KAP family P-loop domain CPT PF07931.7 AIC15426.1 - 0.064 12.8 0.0 3.6 7.1 0.0 2.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DAP3 PF10236.4 AIC15426.1 - 0.069 12.0 0.0 9.1 5.1 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Molydop_binding PF01568.16 AIC15426.1 - 0.072 12.9 0.1 0.68 9.7 0.0 2.5 2 1 1 3 3 2 0 Molydopterin dinucleotide binding domain KTI12 PF08433.5 AIC15426.1 - 0.074 12.2 0.0 2.3 7.3 0.0 2.3 2 0 0 2 2 2 0 Chromatin associated protein KTI12 Vps4_C PF09336.5 AIC15426.1 - 0.11 12.4 0.7 11 5.9 0.0 2.7 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain cobW PF02492.14 AIC15426.1 - 0.11 11.8 0.1 12 5.3 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FTCD_C PF04961.7 AIC15426.1 - 0.12 11.7 2.4 0.3 10.4 1.7 1.6 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase Torsin PF06309.6 AIC15426.1 - 0.12 12.2 0.0 2.7 7.8 0.0 2.4 2 0 0 2 2 2 0 Torsin RibD_C PF01872.12 AIC15427.1 - 4.8e-17 62.2 0.0 1.3e-11 44.4 0.0 2.0 1 1 1 2 2 2 2 RibD C-terminal domain DHFR_1 PF00186.14 AIC15427.1 - 1.7e-08 34.2 0.0 2.2e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Aminotran_5 PF00266.14 AIC15429.1 - 2.5e-34 118.6 0.0 3.3e-34 118.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.15 AIC15429.1 - 0.0013 17.1 0.0 0.0019 16.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme L_lactis_RepB_C PF06430.7 AIC15432.1 - 0.091 12.8 0.1 1.9 8.5 0.1 2.3 1 1 0 1 1 1 0 Lactococcus lactis RepB C-terminus DUF3156 PF11354.3 AIC15432.1 - 0.25 10.6 1.4 0.26 10.6 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3156) Replic_Relax PF13814.1 AIC15434.1 - 0.0043 16.9 0.2 0.0057 16.5 0.1 1.2 1 0 0 1 1 1 1 Replication-relaxation MarR_2 PF12802.2 AIC15434.1 - 0.015 14.9 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.1 AIC15434.1 - 0.019 14.3 0.0 0.043 13.2 0.0 1.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding TrmB PF01978.14 AIC15434.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_36 PF13730.1 AIC15434.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4179 PF13786.1 AIC15436.1 - 0.03 14.5 0.5 0.28 11.4 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) CBM_X PF06204.6 AIC15436.1 - 0.083 12.3 0.6 0.24 10.9 0.0 2.0 2 0 0 2 2 2 0 Putative carbohydrate binding domain Cupredoxin_1 PF13473.1 AIC15438.1 - 0.012 15.4 0.0 0.11 12.4 0.0 2.3 2 1 0 2 2 2 0 Cupredoxin-like domain PPC PF04151.10 AIC15438.1 - 0.056 14.4 0.2 2.1 9.3 0.0 2.5 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain Gmad1 PF10647.4 AIC15440.1 - 6.4e-05 22.4 0.0 0.00012 21.6 0.0 1.4 1 1 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain eIF2A PF08662.6 AIC15440.1 - 0.022 14.4 0.1 4.7 6.8 0.0 2.4 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A FKBP_C PF00254.23 AIC15441.1 - 9.2e-12 44.8 0.0 2.1e-11 43.6 0.0 1.7 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Fe-S_biosyn PF01521.15 AIC15442.1 - 2.2e-25 88.7 0.0 2.5e-25 88.5 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis HTH_45 PF14947.1 AIC15443.1 - 0.00033 20.3 0.1 0.00074 19.2 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_20 PF12840.2 AIC15443.1 - 0.00043 20.0 0.0 0.00084 19.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC15443.1 - 0.0038 16.8 0.0 0.007 16.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF4364 PF14277.1 AIC15443.1 - 0.12 11.9 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) TIMP PF00965.12 AIC15444.1 - 4.9e-05 23.0 0.0 7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase HIG_1_N PF04588.8 AIC15444.1 - 0.054 13.2 0.0 0.16 11.7 0.0 1.8 2 0 0 2 2 2 0 Hypoxia induced protein conserved region MFS_1 PF07690.11 AIC15445.1 - 5.2e-47 160.2 69.5 1.8e-42 145.3 33.5 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 AIC15445.1 - 7.2e-11 41.3 13.5 7.2e-11 41.3 9.4 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.8 AIC15445.1 - 9.8e-07 27.3 13.0 1.6e-06 26.6 9.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) HTH_5 PF01022.15 AIC15446.1 - 1.6e-06 27.6 0.3 4e-06 26.3 0.2 1.7 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.2 AIC15446.1 - 3.8e-06 26.6 0.1 0.00067 19.4 0.2 2.4 1 1 1 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.2 AIC15446.1 - 2.9e-05 23.6 0.1 8.7e-05 22.1 0.0 1.8 2 0 0 2 2 1 1 MarR family HTH_11 PF08279.7 AIC15446.1 - 3.4e-05 23.3 0.1 6.9e-05 22.4 0.1 1.5 1 0 0 1 1 1 1 HTH domain HTH_34 PF13601.1 AIC15446.1 - 4.9e-05 23.2 0.4 9.1e-05 22.4 0.0 1.6 2 0 0 2 2 1 1 Winged helix DNA-binding domain TrmB PF01978.14 AIC15446.1 - 5.2e-05 22.8 0.4 0.00017 21.2 0.1 2.0 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 AIC15446.1 - 6.5e-05 22.5 0.2 0.00015 21.3 0.1 1.6 2 0 0 2 2 1 1 MarR family HTH_24 PF13412.1 AIC15446.1 - 0.0002 20.6 0.0 0.00062 19.0 0.0 1.9 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding PadR PF03551.9 AIC15446.1 - 0.00027 20.6 0.0 0.00075 19.2 0.0 1.8 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Replic_Relax PF13814.1 AIC15446.1 - 0.00029 20.7 0.0 0.00044 20.1 0.0 1.3 1 0 0 1 1 1 1 Replication-relaxation Rrf2 PF02082.15 AIC15446.1 - 0.00041 20.4 0.3 0.0011 19.0 0.2 1.7 1 0 0 1 1 1 1 Transcriptional regulator HTH_IclR PF09339.5 AIC15446.1 - 0.00057 19.4 0.0 0.0013 18.2 0.0 1.7 1 0 0 1 1 1 1 IclR helix-turn-helix domain FaeA PF04703.7 AIC15446.1 - 0.00092 19.3 0.2 0.0019 18.3 0.1 1.5 1 0 0 1 1 1 1 FaeA-like protein HTH_10 PF04967.7 AIC15446.1 - 0.0011 18.5 0.0 0.0028 17.1 0.0 1.7 1 0 0 1 1 1 1 HTH DNA binding domain HTH_27 PF13463.1 AIC15446.1 - 0.0016 18.7 0.0 0.0031 17.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_DeoR PF08220.7 AIC15446.1 - 0.0019 17.6 0.2 0.0037 16.7 0.1 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain B-block_TFIIIC PF04182.7 AIC15446.1 - 0.0021 17.8 0.0 0.0049 16.6 0.0 1.7 1 1 0 1 1 1 1 B-block binding subunit of TFIIIC DUF2250 PF10007.4 AIC15446.1 - 0.0038 17.0 0.9 0.0088 15.9 0.6 1.7 1 1 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) FeoC PF09012.5 AIC15446.1 - 0.0052 16.4 0.2 0.01 15.4 0.2 1.5 1 0 0 1 1 1 1 FeoC like transcriptional regulator GntR PF00392.16 AIC15446.1 - 0.023 14.1 0.2 0.042 13.2 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family LexA_DNA_bind PF01726.11 AIC15446.1 - 0.026 14.0 0.4 0.088 12.3 0.2 1.9 2 0 0 2 2 2 0 LexA DNA binding domain Fe_dep_repress PF01325.14 AIC15446.1 - 0.029 14.3 0.8 0.057 13.3 0.1 1.9 2 0 0 2 2 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_9 PF08221.6 AIC15446.1 - 0.034 14.0 0.1 0.06 13.2 0.1 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_36 PF13730.1 AIC15446.1 - 0.037 14.1 0.0 0.082 13.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF387 PF04079.11 AIC15446.1 - 0.055 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Putative transcriptional regulators (Ypuh-like) AsnC_trans_reg PF01037.16 AIC15448.1 - 4.8e-11 42.1 0.2 5.3e-11 42.0 0.2 1.1 1 0 0 1 1 1 1 AsnC family Gln-synt_C PF00120.19 AIC15449.1 - 2.4e-75 253.0 0.0 3e-75 252.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 AIC15449.1 - 4.2e-15 55.0 0.0 1e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain HTH_AsnC-type PF13404.1 AIC15450.1 - 2.8e-16 58.7 0.1 4.8e-16 58.0 0.1 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 AIC15450.1 - 9.7e-16 56.8 0.0 2.1e-15 55.8 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.16 AIC15450.1 - 5.1e-12 45.3 0.1 8.5e-12 44.6 0.1 1.4 1 0 0 1 1 1 1 AsnC family TrmB PF01978.14 AIC15450.1 - 8.8e-06 25.3 0.1 1.6e-05 24.4 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Fe_dep_repress PF01325.14 AIC15450.1 - 1.7e-05 24.6 0.1 3.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_23 PF13384.1 AIC15450.1 - 2.1e-05 24.0 0.0 4.1e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.1 AIC15450.1 - 0.00015 21.6 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_11 PF08279.7 AIC15450.1 - 0.00019 21.0 0.0 0.00036 20.0 0.0 1.6 1 1 0 1 1 1 1 HTH domain HTH_38 PF13936.1 AIC15450.1 - 0.00026 20.4 0.0 0.00061 19.2 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC15450.1 - 0.00028 20.4 0.0 0.0009 18.8 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.2 AIC15450.1 - 0.00039 20.0 0.0 0.00071 19.1 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.2 AIC15450.1 - 0.00096 18.9 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.15 AIC15450.1 - 0.0014 18.7 0.1 0.0062 16.6 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulator HTH_Mga PF08280.6 AIC15450.1 - 0.0048 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain MarR PF01047.17 AIC15450.1 - 0.0051 16.4 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_30 PF13556.1 AIC15450.1 - 0.0071 15.9 0.0 0.015 14.8 0.0 1.5 2 0 0 2 2 1 1 PucR C-terminal helix-turn-helix domain Sigma70_r4_2 PF08281.7 AIC15450.1 - 0.0076 15.6 0.0 0.016 14.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_IclR PF09339.5 AIC15450.1 - 0.013 15.0 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_10 PF04967.7 AIC15450.1 - 0.02 14.4 0.0 0.046 13.3 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain TetR_N PF00440.18 AIC15450.1 - 0.022 14.4 0.0 0.17 11.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HTH_Crp_2 PF13545.1 AIC15450.1 - 0.025 14.3 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain GntR PF00392.16 AIC15450.1 - 0.027 13.9 0.1 0.047 13.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_29 PF13551.1 AIC15450.1 - 0.032 14.3 0.0 0.058 13.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Trp_repressor PF01371.14 AIC15450.1 - 0.048 13.5 0.1 0.11 12.3 0.0 1.7 2 0 0 2 2 2 0 Trp repressor protein HTH_6 PF01418.12 AIC15450.1 - 0.075 12.7 0.0 0.17 11.6 0.0 1.6 2 0 0 2 2 1 0 Helix-turn-helix domain, rpiR family HTH_27 PF13463.1 AIC15450.1 - 0.095 13.0 0.0 0.24 11.7 0.0 1.7 2 0 0 2 2 1 0 Winged helix DNA-binding domain HTH_40 PF14493.1 AIC15450.1 - 0.1 12.8 0.0 0.17 12.1 0.0 1.4 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_34 PF13601.1 AIC15450.1 - 0.11 12.5 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF190 PF02641.10 AIC15451.1 - 6.1e-17 61.3 0.0 7.3e-17 61.0 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 Lactonase PF10282.4 AIC15453.1 - 3.6e-10 39.4 3.0 3.8e-06 26.2 0.1 3.3 1 1 2 3 3 3 3 Lactonase, 7-bladed beta-propeller Cytochrom_D1 PF02239.11 AIC15453.1 - 1.4e-09 36.7 3.8 1.6e-05 23.4 0.4 3.1 1 1 2 3 3 3 3 Cytochrome D1 heme domain NHL PF01436.16 AIC15453.1 - 3.2e-09 36.2 35.3 0.014 15.3 0.1 10.5 12 1 1 13 13 13 3 NHL repeat SGL PF08450.7 AIC15453.1 - 4.3e-05 23.0 5.5 0.0073 15.7 2.6 3.1 1 1 0 2 2 2 1 SMP-30/Gluconolaconase/LRE-like region He_PIG PF05345.7 AIC15453.1 - 0.0013 18.7 6.5 2.4 8.2 0.0 4.5 4 0 0 4 4 4 2 Putative Ig domain Arylesterase PF01731.15 AIC15453.1 - 0.0069 16.3 16.8 0.45 10.5 0.1 5.8 2 1 5 7 7 7 2 Arylesterase DUF4346 PF14251.1 AIC15453.1 - 0.69 9.6 3.6 47 3.7 0.1 3.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4346) PBP5_C PF07943.8 AIC15453.1 - 0.82 9.7 3.7 55 3.8 0.0 4.2 4 1 1 5 5 5 0 Penicillin-binding protein 5, C-terminal domain DUF190 PF02641.10 AIC15454.1 - 8.5e-14 51.2 0.1 9.1e-14 51.1 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 Hydrolase_3 PF08282.7 AIC15455.1 - 1.3e-07 31.4 0.1 8e-07 28.8 0.0 2.1 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 AIC15455.1 - 0.00064 19.0 0.0 0.00099 18.4 0.0 1.3 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase YqcI_YcgG PF08892.6 AIC15455.1 - 0.015 14.8 0.0 0.031 13.8 0.0 1.5 1 1 0 1 1 1 0 YqcI/YcgG family Bcr-Abl_Oligo PF09036.5 AIC15455.1 - 0.026 14.4 0.1 0.39 10.7 0.0 2.3 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain ELFV_dehydrog PF00208.16 AIC15456.1 - 9e-74 248.1 6.6 9.3e-74 248.0 4.1 1.4 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.13 AIC15456.1 - 1.2e-55 186.6 0.0 2.2e-55 185.7 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.14 AIC15456.1 - 0.046 12.8 0.3 0.095 11.8 0.2 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MttA_Hcf106 PF02416.11 AIC15457.1 - 2e-11 42.8 0.3 2.8e-11 42.3 0.2 1.4 1 1 0 1 1 1 1 mttA/Hcf106 family Translin PF01997.11 AIC15458.1 - 1.8e-27 96.2 0.2 2.2e-27 95.9 0.1 1.1 1 0 0 1 1 1 1 Translin family Hjc PF01870.13 AIC15459.1 - 5.6e-08 32.2 0.0 7.9e-08 31.8 0.0 1.3 1 0 0 1 1 1 1 Archaeal holliday junction resolvase (hjc) VRR_NUC PF08774.6 AIC15459.1 - 0.095 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 VRR-NUC domain Cyclophil_like PF04126.8 AIC15460.1 - 1.2e-28 99.1 0.0 1.5e-28 98.8 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin-like SNase PF00565.12 AIC15461.1 - 2.5e-09 37.3 0.0 6.8e-09 35.9 0.0 1.7 2 0 0 2 2 2 1 Staphylococcal nuclease homologue TFIIB PF00382.14 AIC15462.1 - 1.9e-31 107.6 1.4 7.3e-15 54.5 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 AIC15462.1 - 2.2e-11 42.8 0.2 3.8e-11 42.1 0.1 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4 PF04545.11 AIC15462.1 - 3e-05 23.2 0.1 0.0016 17.6 0.0 2.5 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_AsnC-type PF13404.1 AIC15462.1 - 0.00034 20.0 0.2 0.0022 17.4 0.0 2.5 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.7 AIC15462.1 - 0.0026 17.3 0.5 0.024 14.2 0.1 2.5 2 0 0 2 2 2 1 HTH domain LacI PF00356.16 AIC15462.1 - 0.0026 17.3 1.3 0.64 9.6 0.0 3.4 3 0 0 3 3 3 1 Bacterial regulatory proteins, lacI family Rrf2 PF02082.15 AIC15462.1 - 0.0035 17.4 0.2 4.4 7.4 0.0 2.7 2 1 0 2 2 2 2 Transcriptional regulator HARE-HTH PF05066.8 AIC15462.1 - 0.01 16.1 0.1 0.043 14.1 0.0 2.0 2 0 0 2 2 2 1 HB1, ASXL, restriction endonuclease HTH domain Sigma70_r4_2 PF08281.7 AIC15462.1 - 0.02 14.3 0.1 0.098 12.1 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.1 AIC15462.1 - 0.022 14.4 0.3 0.11 12.1 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain HTH_24 PF13412.1 AIC15462.1 - 0.034 13.5 0.9 0.13 11.6 0.0 2.5 3 0 0 3 3 3 0 Winged helix-turn-helix DNA-binding GerE PF00196.14 AIC15462.1 - 0.054 12.8 0.2 0.47 9.7 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory proteins, luxR family TetR_N PF00440.18 AIC15462.1 - 0.09 12.4 0.1 3.7 7.2 0.0 2.5 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family YibE_F PF07907.6 AIC15462.1 - 0.1 11.7 0.1 0.24 10.5 0.0 1.5 2 0 0 2 2 2 0 YibE/F-like protein HTH_Tnp_ISL3 PF13542.1 AIC15462.1 - 0.13 11.4 0.4 1.3 8.2 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain of transposase family ISL3 SCIMP PF15050.1 AIC15462.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 SCIMP protein Cation_efflux PF01545.16 AIC15463.1 - 6.7e-71 238.6 23.4 7e-55 186.1 8.4 3.0 2 1 1 3 3 3 3 Cation efflux family AMP-binding_C_2 PF14535.1 AIC15463.1 - 1.9e-05 24.6 2.7 0.00021 21.3 0.1 2.6 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain DUF1319 PF07028.6 AIC15463.1 - 0.018 15.2 0.6 0.59 10.3 0.1 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1319) NMN_transporter PF04973.7 AIC15463.1 - 3.7 6.9 9.5 0.32 10.4 0.4 2.5 2 1 0 2 2 2 0 Nicotinamide mononucleotide transporter Carb_kinase PF01256.12 AIC15464.1 - 1.7e-40 138.8 0.2 2e-40 138.5 0.1 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.10 AIC15464.1 - 6.7e-06 25.4 0.0 1e-05 24.8 0.0 1.2 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.7 AIC15464.1 - 0.0035 16.5 0.1 0.011 14.9 0.0 1.9 2 1 0 2 2 2 1 Phosphomethylpyrimidine kinase adh_short PF00106.20 AIC15465.1 - 1.9e-30 105.9 0.0 2.6e-30 105.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AIC15465.1 - 5.7e-12 45.9 0.0 7.4e-12 45.5 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AIC15465.1 - 4.7e-10 39.4 0.0 7.4e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 AIC15465.1 - 4.5e-07 29.2 0.0 6e-07 28.8 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.1 AIC15465.1 - 8.5e-06 25.8 0.0 4.6e-05 23.4 0.0 2.1 1 1 1 2 2 2 1 NADH(P)-binding Epimerase PF01370.16 AIC15465.1 - 0.0034 16.8 0.0 0.0066 15.9 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 AIC15465.1 - 0.0037 17.0 0.4 0.0086 15.8 0.3 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase tRNA_bind PF01588.15 AIC15466.1 - 5.3e-19 67.8 0.1 6.2e-19 67.6 0.0 1.1 1 0 0 1 1 1 1 Putative tRNA binding domain DUF556 PF04476.8 AIC15466.1 - 0.11 11.6 0.1 0.37 9.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF556) EF-hand_1 PF00036.27 AIC15466.1 - 0.12 11.7 0.1 0.29 10.5 0.1 1.6 1 0 0 1 1 1 0 EF hand PAC2 PF09754.4 AIC15467.1 - 1.8e-25 90.1 0.0 2e-25 89.9 0.0 1.0 1 0 0 1 1 1 1 PAC2 family NAD_binding_2 PF03446.10 AIC15468.1 - 1.3e-40 138.9 0.7 2.3e-40 138.0 0.1 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.1 AIC15468.1 - 2.7e-26 92.0 0.5 4.9e-26 91.1 0.4 1.4 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 3HCDH_N PF02737.13 AIC15468.1 - 5.3e-09 35.9 0.0 0.00012 21.8 0.1 2.2 1 1 1 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.12 AIC15468.1 - 4.1e-08 33.5 0.4 2.6e-07 30.9 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.14 AIC15468.1 - 4.4e-07 29.2 0.0 7e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.15 AIC15468.1 - 0.0019 18.3 0.1 0.0071 16.4 0.0 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase NAD_binding_10 PF13460.1 AIC15468.1 - 0.0045 17.0 0.1 0.0095 15.9 0.1 1.6 1 0 0 1 1 1 1 NADH(P)-binding ApbA PF02558.11 AIC15468.1 - 0.012 15.0 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA NAD_Gly3P_dh_N PF01210.18 AIC15468.1 - 0.068 12.8 0.1 0.14 11.9 0.1 1.7 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_7 PF13241.1 AIC15468.1 - 0.093 12.9 0.1 0.45 10.8 0.0 1.9 2 0 0 2 2 2 0 Putative NAD(P)-binding TrkA_N PF02254.13 AIC15468.1 - 0.1 12.6 0.1 0.44 10.5 0.0 2.3 2 1 0 2 2 2 0 TrkA-N domain GMC_oxred_N PF00732.14 AIC15470.1 - 2.4e-36 125.4 0.7 3.3e-36 124.9 0.5 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.8 AIC15470.1 - 7.4e-25 87.9 0.0 1.4e-24 87.0 0.0 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.19 AIC15470.1 - 3.8e-08 32.5 3.7 0.00017 20.6 1.0 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.19 AIC15470.1 - 1.6e-07 30.6 1.6 4.2e-05 22.6 0.2 2.3 2 0 0 2 2 2 2 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AIC15470.1 - 0.00026 20.9 1.1 0.00082 19.3 0.8 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 AIC15470.1 - 0.00043 18.8 0.9 0.00077 18.0 0.6 1.4 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.14 AIC15470.1 - 0.00044 19.4 0.1 0.00072 18.7 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.9 AIC15470.1 - 0.00069 19.5 0.3 0.0018 18.2 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ApbA PF02558.11 AIC15470.1 - 0.0027 17.1 0.1 0.005 16.2 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Pyr_redox_3 PF13738.1 AIC15470.1 - 0.0036 17.3 0.4 3 7.8 0.2 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase ELFV_dehydrog PF00208.16 AIC15470.1 - 0.004 16.7 0.2 0.004 16.7 0.2 1.5 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GDI PF00996.13 AIC15470.1 - 0.0056 15.0 0.0 0.0089 14.3 0.0 1.2 1 0 0 1 1 1 1 GDP dissociation inhibitor Pyr_redox PF00070.22 AIC15470.1 - 0.0057 17.0 0.1 0.62 10.5 0.1 3.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 AIC15470.1 - 0.0066 15.5 0.8 0.011 14.8 0.6 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.17 AIC15470.1 - 0.01 14.7 0.1 0.069 12.0 0.0 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.7 AIC15470.1 - 0.021 13.7 0.5 0.043 12.7 0.3 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_Gly3P_dh_N PF01210.18 AIC15470.1 - 0.054 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.13 AIC15470.1 - 0.073 12.7 0.1 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain CarboxypepD_reg PF13620.1 AIC15471.1 - 0.00011 22.1 0.0 0.00023 21.1 0.0 1.6 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF290 PF01060.18 AIC15471.1 - 0.00054 19.9 0.0 0.00091 19.1 0.0 1.4 1 1 0 1 1 1 1 Transthyretin-like family DUF4480 PF13715.1 AIC15471.1 - 0.031 14.2 0.0 0.053 13.5 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4480) C2 PF00168.25 AIC15471.1 - 0.075 12.8 0.0 15 5.5 0.0 2.4 2 0 0 2 2 2 0 C2 domain Dioxygenase_C PF00775.16 AIC15471.1 - 0.082 12.1 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Dioxygenase Radical_SAM PF04055.16 AIC15473.1 - 4.4e-12 46.4 0.1 6.5e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 AIC15473.1 - 0.00064 19.7 0.0 0.0016 18.4 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 AIC15473.1 - 0.0039 17.3 0.0 0.0085 16.2 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain DUF1848 PF08902.6 AIC15473.1 - 0.052 13.0 1.9 0.1 12.0 1.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) Glyco_hydro_2_C PF02836.12 AIC15473.1 - 0.13 11.0 1.4 1.8 7.3 0.1 2.6 1 1 1 2 2 2 0 Glycosyl hydrolases family 2, TIM barrel domain NUDIX PF00293.23 AIC15474.1 - 5.5e-22 77.8 0.0 6.7e-22 77.5 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.1 AIC15474.1 - 0.00039 19.8 0.0 0.00066 19.0 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain ArsA_ATPase PF02374.10 AIC15475.1 - 0.071 12.1 0.1 0.088 11.8 0.1 1.2 1 0 0 1 1 1 0 Anion-transporting ATPase DUF1090 PF06476.7 AIC15475.1 - 0.19 11.4 2.2 0.26 10.9 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) Trns_repr_metal PF02583.12 AIC15475.1 - 0.2 11.8 2.3 3.5 7.8 0.1 2.5 2 1 1 3 3 3 0 Metal-sensitive transcriptional repressor UPF0051 PF01458.12 AIC15476.1 - 7.5e-72 241.5 0.3 1.1e-71 240.9 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) Pico_P1A PF02226.11 AIC15476.1 - 0.049 13.3 0.3 14 5.4 0.0 2.7 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) UPF0051 PF01458.12 AIC15477.1 - 2.5e-58 197.2 0.9 3.4e-58 196.7 0.6 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) Rieske PF00355.21 AIC15478.1 - 2.8e-16 58.8 0.0 3.2e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 AIC15478.1 - 1.1e-13 50.7 0.0 1.3e-13 50.5 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Aminotran_5 PF00266.14 AIC15479.1 - 8.2e-154 511.8 0.5 9.3e-154 511.6 0.4 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 AIC15479.1 - 1.3e-05 24.4 0.0 2.5e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 AIC15479.1 - 0.00037 19.5 0.1 0.00065 18.7 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.15 AIC15479.1 - 0.0016 16.8 0.0 0.0024 16.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SelA PF03841.8 AIC15479.1 - 0.0048 15.6 0.1 0.015 14.0 0.0 1.6 1 1 0 1 1 1 1 L-seryl-tRNA selenium transferase DegT_DnrJ_EryC1 PF01041.12 AIC15479.1 - 0.022 13.8 0.1 0.037 13.0 0.0 1.4 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family NifU_N PF01592.11 AIC15480.1 - 1.2e-32 112.4 0.0 1.4e-32 112.2 0.0 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Lip_prot_lig_C PF10437.4 AIC15480.1 - 0.026 14.1 0.3 0.05 13.2 0.1 1.6 1 1 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus SAM_1 PF00536.25 AIC15480.1 - 0.13 12.4 0.1 0.27 11.4 0.1 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DZR PF12773.2 AIC15481.1 - 0.006 16.3 1.3 0.0087 15.8 0.9 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF3647 PF12363.3 AIC15481.1 - 0.0063 16.6 0.1 1.3 9.1 0.0 2.2 1 1 1 2 2 2 2 Phage protein HypA PF01155.14 AIC15481.1 - 0.13 11.9 0.8 0.18 11.4 0.6 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Opy2 PF09463.5 AIC15481.1 - 1.7 8.8 4.8 19 5.4 0.3 2.1 2 0 0 2 2 2 0 Opy2 protein Zn-ribbon_8 PF09723.5 AIC15481.1 - 2.1 8.3 6.0 0.96 9.4 2.2 1.9 2 1 0 2 2 2 0 Zinc ribbon domain zf-trcl PF13451.1 AIC15481.1 - 2.6 7.7 7.8 5.9 6.5 1.1 2.2 1 1 1 2 2 2 0 Probable zinc-binding domain PAP2 PF01569.16 AIC15482.1 - 1.5e-20 73.1 7.2 1.5e-20 73.1 5.0 2.1 1 1 1 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.1 AIC15482.1 - 0.00018 21.1 5.9 0.00018 21.1 4.1 1.6 1 1 0 1 1 1 1 PAP2 superfamily PAP2_C PF14360.1 AIC15482.1 - 0.054 13.7 0.4 0.054 13.7 0.3 2.7 3 0 0 3 3 3 0 PAP2 superfamily C-terminal DUF2298 PF10060.4 AIC15482.1 - 0.91 8.2 9.8 1.5 7.5 2.3 2.1 2 0 0 2 2 2 0 Uncharacterized membrane protein (DUF2298) DUF4064 PF13273.1 AIC15482.1 - 1.8 8.6 9.7 3.2 7.9 4.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Peptidase_M50B PF13398.1 AIC15482.1 - 4.5 6.6 12.4 0.81 9.0 1.2 2.4 3 0 0 3 3 3 0 Peptidase M50B-like CAP18_C PF12153.3 AIC15483.1 - 0.83 9.3 2.9 0.83 9.3 0.3 2.1 2 0 0 2 2 2 0 LPS binding domain of CAP18 (C terminal) DAO PF01266.19 AIC15484.1 - 2.5e-07 29.9 0.2 0.0013 17.7 0.0 2.2 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AIC15484.1 - 3.4e-07 29.4 0.2 0.0028 16.5 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain Trp_halogenase PF04820.9 AIC15484.1 - 0.0029 16.3 0.1 0.14 10.7 0.1 2.2 2 0 0 2 2 2 1 Tryptophan halogenase Lycopene_cycl PF05834.7 AIC15484.1 - 0.0095 14.8 0.0 0.016 14.1 0.0 1.4 1 1 0 1 1 1 1 Lycopene cyclase protein GDI PF00996.13 AIC15484.1 - 0.012 14.0 0.0 0.022 13.1 0.0 1.4 1 0 0 1 1 1 0 GDP dissociation inhibitor Thi4 PF01946.12 AIC15484.1 - 0.018 14.1 0.9 0.074 12.1 0.7 2.0 2 1 0 2 2 2 0 Thi4 family FAD_oxidored PF12831.2 AIC15484.1 - 0.11 11.5 0.4 0.24 10.4 0.2 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase NAD_binding_8 PF13450.1 AIC15484.1 - 0.11 12.4 0.0 0.32 11.0 0.0 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.9 AIC15484.1 - 0.12 10.8 0.6 0.29 9.5 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein HAD_2 PF13419.1 AIC15485.1 - 8.9e-17 61.8 0.0 1.2e-16 61.4 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AIC15485.1 - 9.2e-13 47.7 0.0 1.4e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.21 AIC15485.1 - 1.7e-08 35.1 0.0 1.9e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.5 AIC15485.1 - 0.0012 18.2 0.0 0.0021 17.4 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase DUF962 PF06127.6 AIC15486.1 - 0.00016 21.5 0.3 0.00021 21.0 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF962) DUF3923 PF13061.1 AIC15486.1 - 0.13 12.1 0.9 0.19 11.6 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3923) HIT PF01230.18 AIC15487.1 - 2e-23 82.7 0.1 2.5e-23 82.4 0.1 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.3 AIC15487.1 - 4.6e-16 59.0 0.0 5.8e-16 58.7 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.10 AIC15487.1 - 0.00072 19.1 0.4 0.0017 17.9 0.3 1.5 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 DUF2443 PF10398.4 AIC15488.1 - 0.086 12.6 0.1 1.3 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) PAPS_reduct PF01507.14 AIC15489.1 - 1.9e-44 151.5 0.0 2.4e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ATP-sulfurylase PF01747.12 AIC15490.1 - 5.9e-88 293.7 0.3 7.9e-88 293.3 0.2 1.1 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.1 AIC15490.1 - 2.1e-40 137.7 0.0 3.4e-40 137.0 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain HTH_5 PF01022.15 AIC15493.1 - 1.8e-09 37.1 0.0 3e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.2 AIC15493.1 - 1.8e-08 34.0 0.0 3.5e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.14 AIC15493.1 - 9.1e-05 22.0 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC15493.1 - 0.00018 20.8 0.1 0.0005 19.3 0.1 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_45 PF14947.1 AIC15493.1 - 0.00026 20.7 0.5 0.00042 20.0 0.4 1.3 1 1 0 1 1 1 1 Winged helix-turn-helix HTH_11 PF08279.7 AIC15493.1 - 0.0011 18.5 0.0 0.0019 17.7 0.0 1.4 1 0 0 1 1 1 1 HTH domain Phage_rep_org_N PF09681.5 AIC15493.1 - 0.0027 17.2 0.0 0.0035 16.9 0.0 1.2 1 0 0 1 1 1 1 N-terminal phage replisome organiser (Phage_rep_org_N) B-block_TFIIIC PF04182.7 AIC15493.1 - 0.017 14.9 0.3 0.11 12.3 0.0 2.0 1 1 1 2 2 2 0 B-block binding subunit of TFIIIC Nup35_RRM PF05172.8 AIC15493.1 - 0.02 14.6 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif MarR_2 PF12802.2 AIC15493.1 - 0.083 12.5 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 MarR family DDE_Tnp_2 PF04693.7 AIC15493.1 - 0.09 11.7 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Archaeal putative transposase ISC1217 LexA_DNA_bind PF01726.11 AIC15493.1 - 0.1 12.2 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain HTH_29 PF13551.1 AIC15493.1 - 0.12 12.5 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn helix Penicillinase_R PF03965.11 AIC15493.1 - 0.14 12.2 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Penicillinase repressor DUF3179 PF11376.3 AIC15494.1 - 8.7e-94 313.5 0.0 1.3e-93 312.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3179) DUF1887 PF09002.6 AIC15496.1 - 0.00052 18.5 0.1 0.00065 18.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1887) P16-Arc PF04699.9 AIC15496.1 - 0.056 13.4 0.1 0.09 12.7 0.1 1.3 1 0 0 1 1 1 0 ARP2/3 complex 16 kDa subunit (p16-Arc) WAK_assoc PF14380.1 AIC15497.1 - 0.073 13.5 0.9 0.082 13.4 0.0 1.5 2 0 0 2 2 2 0 Wall-associated receptor kinase C-terminal HTH_10 PF04967.7 AIC15498.1 - 6.2e-19 67.3 0.3 1.1e-18 66.5 0.2 1.4 1 0 0 1 1 1 1 HTH DNA binding domain HTH_5 PF01022.15 AIC15498.1 - 0.0097 15.5 0.4 0.049 13.2 0.2 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family Put_DNA-bind_N PF06971.8 AIC15498.1 - 0.049 13.3 0.0 0.32 10.7 0.0 2.2 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus MarR_2 PF12802.2 AIC15498.1 - 0.059 13.0 0.1 0.26 10.9 0.1 2.1 2 0 0 2 2 2 0 MarR family Sigma70_r4_2 PF08281.7 AIC15498.1 - 0.13 11.7 0.7 1.4 8.4 0.5 2.3 1 1 0 1 1 1 0 Sigma-70, region 4 MerB PF03243.10 AIC15499.1 - 2.2e-38 130.9 0.0 3.2e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 Alkylmercury lyase HTH_15 PF12324.3 AIC15499.1 - 0.00068 19.2 0.0 0.0016 18.0 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain of alkylmercury lyase DUF1495 PF07381.6 AIC15499.1 - 0.021 14.5 0.0 0.039 13.6 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) DUF3816 PF12822.2 AIC15500.1 - 0.039 13.8 13.0 0.085 12.7 9.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) Cation_efflux PF01545.16 AIC15500.1 - 2.7 6.9 5.2 3.9 6.4 3.6 1.3 1 1 0 1 1 1 0 Cation efflux family RseC_MucC PF04246.7 AIC15500.1 - 3.8 7.1 7.4 0.23 11.0 1.2 1.8 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Rhomboid PF01694.17 AIC15500.1 - 3.9 7.5 9.2 5.6 6.9 4.4 2.0 1 1 1 2 2 2 0 Rhomboid family AhpC-TSA PF00578.16 AIC15501.1 - 1.2e-14 54.0 0.0 1.7e-14 53.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AIC15501.1 - 6.9e-11 41.8 0.0 1.1e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.1 AIC15501.1 - 3.1e-08 33.6 0.0 4.6e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.1 AIC15501.1 - 8.9e-07 29.1 0.1 1.7e-06 28.2 0.0 1.4 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin PF00085.15 AIC15501.1 - 8.5e-06 25.4 0.0 0.00011 21.8 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_7 PF13899.1 AIC15501.1 - 0.00026 20.9 0.1 0.00055 19.9 0.0 1.6 1 1 0 1 1 1 1 Thioredoxin-like SCO1-SenC PF02630.9 AIC15501.1 - 0.0017 18.0 0.0 0.0029 17.2 0.0 1.4 1 1 0 1 1 1 1 SCO1/SenC NADH_4Fe-4S PF10589.4 AIC15501.1 - 0.033 13.3 0.1 0.061 12.4 0.0 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region DUF2627 PF11118.3 AIC15502.1 - 0.14 12.3 0.9 0.31 11.1 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) HxlR PF01638.12 AIC15503.1 - 4.4e-22 77.5 0.1 5.8e-22 77.1 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.9 AIC15503.1 - 0.0027 17.4 0.1 0.0049 16.5 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family B-block_TFIIIC PF04182.7 AIC15503.1 - 0.0044 16.8 0.0 0.0056 16.4 0.0 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_24 PF13412.1 AIC15503.1 - 0.0073 15.6 0.2 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.17 AIC15503.1 - 0.052 13.2 0.0 0.079 12.6 0.0 1.3 1 0 0 1 1 1 0 MarR family RepL PF05732.6 AIC15503.1 - 0.053 12.7 0.0 0.061 12.5 0.0 1.1 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) RNA12 PF10443.4 AIC15503.1 - 0.11 10.9 0.0 0.14 10.6 0.0 1.1 1 0 0 1 1 1 0 RNA12 protein RseC_MucC PF04246.7 AIC15504.1 - 0.014 15.0 0.1 0.031 13.8 0.0 1.6 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC MFS_1 PF07690.11 AIC15504.1 - 0.062 12.0 0.0 0.066 11.9 0.0 1.0 1 0 0 1 1 1 0 Major Facilitator Superfamily ADP_ribosyl_GH PF03747.9 AIC15504.1 - 0.16 11.6 0.7 8.2 6.1 0.4 2.1 2 0 0 2 2 2 0 ADP-ribosylglycohydrolase Bacteriocin_IIc PF10439.4 AIC15504.1 - 1.3 9.2 5.0 1.8 8.7 3.5 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Pyr_redox_2 PF07992.9 AIC15505.1 - 4.7e-40 137.6 1.4 2.3e-37 128.8 1.0 3.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.17 AIC15505.1 - 1.1e-29 102.6 0.4 2.5e-29 101.5 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.22 AIC15505.1 - 3.7e-18 65.7 1.4 5.4e-14 52.3 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.17 AIC15505.1 - 2.5e-17 62.8 2.4 3.2e-14 52.6 0.1 3.3 2 2 1 3 3 3 2 Glucose inhibited division protein A Pyr_redox_3 PF13738.1 AIC15505.1 - 1.8e-11 44.4 0.0 8.5e-07 29.2 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 AIC15505.1 - 6e-08 32.1 6.7 2.1e-06 27.1 1.0 2.9 2 1 1 3 3 3 2 FAD dependent oxidoreductase HI0933_like PF03486.9 AIC15505.1 - 3.4e-07 29.1 7.2 0.0026 16.3 0.8 4.0 3 1 1 4 4 4 2 HI0933-like protein FAD_binding_2 PF00890.19 AIC15505.1 - 1.3e-06 27.5 5.5 6.5e-05 21.9 1.0 2.8 2 1 1 3 3 3 2 FAD binding domain K_oxygenase PF13434.1 AIC15505.1 - 6e-06 25.4 0.2 0.051 12.4 0.0 3.1 2 1 1 3 3 3 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.1 AIC15505.1 - 4.9e-05 23.2 0.9 0.092 12.7 0.4 2.7 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Thi4 PF01946.12 AIC15505.1 - 0.00026 20.1 0.4 0.0089 15.1 0.2 2.5 2 0 0 2 2 2 1 Thi4 family DAO PF01266.19 AIC15505.1 - 0.00038 19.4 4.4 0.0079 15.1 0.6 3.3 1 1 2 3 3 3 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.14 AIC15505.1 - 0.0061 15.6 0.8 0.28 10.1 0.0 2.2 2 0 0 2 2 2 1 FAD binding domain Lycopene_cycl PF05834.7 AIC15505.1 - 0.035 13.0 0.4 0.43 9.4 0.3 2.4 3 0 0 3 3 3 0 Lycopene cyclase protein NAD_binding_7 PF13241.1 AIC15505.1 - 0.079 13.2 0.5 4.8 7.4 0.0 2.7 2 1 0 2 2 2 0 Putative NAD(P)-binding 3HCDH_N PF02737.13 AIC15505.1 - 0.082 12.5 2.6 0.14 11.7 0.0 2.7 3 1 1 4 4 4 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF3357 PF11837.3 AIC15506.1 - 0.39 10.5 2.5 0.74 9.6 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF1464 PF07318.7 AIC15507.1 - 0.13 11.0 0.2 0.18 10.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) p53-inducible11 PF14936.1 AIC15507.1 - 0.3 10.9 1.8 0.36 10.7 1.2 1.1 1 0 0 1 1 1 0 Tumour protein p53-inducible protein 11 IBV_3C PF03620.8 AIC15507.1 - 1.1 9.2 5.0 1.2 9.1 0.4 2.4 1 1 1 2 2 2 0 IBV 3C protein Tetraspannin PF00335.15 AIC15507.1 - 6.6 5.9 9.1 8.4 5.5 6.3 1.1 1 0 0 1 1 1 0 Tetraspanin family HTH_45 PF14947.1 AIC15508.1 - 6.1e-20 70.8 0.5 7.3e-20 70.5 0.3 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC15508.1 - 0.00061 19.4 0.1 0.00077 19.1 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_27 PF13463.1 AIC15508.1 - 0.0061 16.8 0.0 0.0087 16.3 0.0 1.4 1 1 0 1 1 1 1 Winged helix DNA-binding domain HxlR PF01638.12 AIC15508.1 - 0.013 15.1 0.1 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Penicillinase_R PF03965.11 AIC15508.1 - 0.11 12.6 0.1 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Penicillinase repressor YfdX PF10938.3 AIC15509.1 - 0.041 13.5 11.4 0.42 10.2 0.0 3.7 3 0 0 3 3 3 0 YfdX protein PhoU PF01895.14 AIC15509.1 - 2.5 8.5 7.3 1 9.8 0.1 2.8 3 0 0 3 3 3 0 PhoU domain HhH-GPD PF00730.20 AIC15511.1 - 7.8e-27 93.6 0.0 1.2e-26 93.0 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.18 AIC15511.1 - 1.9e-07 30.3 1.7 3.3e-07 29.6 0.0 2.4 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_5 PF14520.1 AIC15511.1 - 2.2e-05 24.5 0.2 0.00026 21.0 0.1 2.4 1 1 0 1 1 1 1 Helix-hairpin-helix domain DUF2400 PF09674.5 AIC15511.1 - 0.0026 17.4 0.0 0.0058 16.3 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2400) DUF3349 PF11829.3 AIC15511.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3349) DUF521 PF04412.8 AIC15512.1 - 4.8e-110 367.8 0.0 6e-110 367.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF521) DUF126 PF01989.11 AIC15513.1 - 1.8e-28 98.0 0.0 3.1e-28 97.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function DUF126 TF_Zn_Ribbon PF08271.7 AIC15514.1 - 3.1e-07 29.5 0.3 4.8e-07 28.9 0.2 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.6 AIC15514.1 - 0.00022 20.8 1.1 0.00028 20.4 0.2 1.5 2 1 0 2 2 2 1 Putative transposase DNA-binding domain DZR PF12773.2 AIC15514.1 - 0.003 17.3 0.4 0.0049 16.6 0.3 1.3 1 0 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.5 AIC15514.1 - 0.0052 16.7 2.7 0.64 10.0 0.1 2.5 2 1 0 2 2 2 2 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 AIC15514.1 - 0.01 15.6 0.4 0.017 14.9 0.3 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Nudix_N_2 PF14803.1 AIC15514.1 - 0.013 15.1 4.4 0.11 12.1 3.1 2.1 1 1 0 1 1 1 0 Nudix N-terminal FYDLN_acid PF09538.5 AIC15514.1 - 0.014 15.9 1.4 0.018 15.6 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Zn_Tnp_IS91 PF14319.1 AIC15514.1 - 0.037 13.5 0.1 0.047 13.1 0.0 1.3 1 1 0 1 1 1 0 Transposase zinc-binding domain zf-Mss51 PF13824.1 AIC15514.1 - 0.038 13.8 1.3 0.076 12.8 0.9 1.7 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 FYVE PF01363.16 AIC15514.1 - 0.091 12.6 0.5 0.098 12.5 0.3 1.2 1 1 0 1 1 1 0 FYVE zinc finger DUF1272 PF06906.6 AIC15514.1 - 0.096 12.5 1.4 0.82 9.5 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1272) zf-ribbon_3 PF13248.1 AIC15514.1 - 0.1 11.8 5.2 0.27 10.4 3.6 1.7 1 1 0 1 1 1 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.7 AIC15514.1 - 0.14 12.2 1.5 0.27 11.3 1.1 1.4 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase C1_1 PF00130.17 AIC15514.1 - 0.14 11.8 0.7 0.2 11.3 0.5 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) UPF0547 PF10571.4 AIC15514.1 - 0.16 11.7 0.9 0.34 10.6 0.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 zf-IS66 PF13005.2 AIC15514.1 - 0.23 11.4 3.1 0.39 10.7 0.0 2.4 2 1 0 2 2 2 0 zinc-finger binding domain of transposase IS66 Auto_anti-p27 PF06677.7 AIC15514.1 - 0.35 10.6 1.6 0.62 9.8 1.1 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) PhnA_Zn_Ribbon PF08274.7 AIC15514.1 - 0.43 10.3 3.2 1.6 8.6 2.2 1.8 1 1 0 1 1 1 0 PhnA Zinc-Ribbon zf-NADH-PPase PF09297.6 AIC15514.1 - 0.49 9.9 3.2 3.2 7.3 2.3 2.0 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain DUF1610 PF07754.6 AIC15514.1 - 2.6 8.2 6.4 22 5.3 1.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zinc_ribbon_2 PF13240.1 AIC15514.1 - 9.4 5.8 9.0 1.2e+02 2.3 6.3 2.2 1 1 0 1 1 1 0 zinc-ribbon domain ATP_bind_3 PF01171.15 AIC15515.1 - 1.6e-19 70.0 0.0 2.6e-19 69.4 0.0 1.3 1 0 0 1 1 1 1 PP-loop family NAD_synthase PF02540.12 AIC15515.1 - 0.015 14.2 0.1 0.021 13.7 0.1 1.2 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.11 AIC15515.1 - 0.019 13.5 0.1 0.03 12.8 0.1 1.3 1 0 0 1 1 1 0 tRNA methyl transferase QueC PF06508.8 AIC15515.1 - 0.068 12.4 0.0 0.14 11.4 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC DUF2392 PF10288.4 AIC15515.1 - 0.092 13.0 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2392) RecR PF02132.10 AIC15515.1 - 0.19 11.1 10.4 0.58 9.6 1.3 2.8 3 0 0 3 3 3 0 RecR protein Rpr2 PF04032.11 AIC15515.1 - 0.22 11.3 6.8 15 5.5 0.1 3.9 3 1 1 4 4 4 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain FYVE PF01363.16 AIC15515.1 - 0.24 11.3 3.8 2.3 8.1 0.3 3.0 3 0 0 3 3 3 0 FYVE zinc finger DUF4206 PF13901.1 AIC15515.1 - 0.37 10.2 2.4 4.3 6.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4206) Bac_luciferase PF00296.15 AIC15516.1 - 4.8e-58 196.7 0.0 5.1e-58 196.6 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Methyltransf_18 PF12847.2 AIC15518.1 - 5.9e-13 49.3 0.0 1.2e-12 48.3 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15518.1 - 4.1e-12 45.9 0.0 5.1e-12 45.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15518.1 - 6.4e-11 42.2 0.0 1.6e-10 40.9 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC15518.1 - 9.1e-10 38.9 0.0 1.8e-09 37.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15518.1 - 4.4e-09 36.7 0.0 1.1e-08 35.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC15518.1 - 7.4e-09 35.6 0.1 1.5e-08 34.6 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15518.1 - 1.5e-08 34.8 0.0 2.9e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC15518.1 - 6.2e-05 22.4 0.0 0.00011 21.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.13 AIC15518.1 - 0.00017 20.7 0.0 0.00061 18.9 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.15 AIC15518.1 - 0.0013 17.8 0.0 0.014 14.5 0.0 2.2 2 1 1 3 3 3 1 Mycolic acid cyclopropane synthetase PCMT PF01135.14 AIC15518.1 - 0.017 14.6 0.0 0.028 13.9 0.0 1.3 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SnoaL PF07366.7 AIC15518.1 - 0.049 13.2 0.0 0.084 12.4 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase RrnaAD PF00398.15 AIC15518.1 - 0.17 10.8 0.0 0.25 10.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase MarR_2 PF12802.2 AIC15519.1 - 9.2e-15 54.0 0.0 1.7e-14 53.2 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.17 AIC15519.1 - 1.3e-11 44.0 0.0 2.1e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 AIC15519.1 - 1.2e-08 35.1 0.1 2.8e-08 33.9 0.1 1.7 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.14 AIC15519.1 - 2.2e-06 27.2 0.0 3.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_42 PF06224.7 AIC15519.1 - 0.00019 20.8 0.4 0.0002 20.7 0.3 1.1 1 0 0 1 1 1 1 Winged helix DNA-binding domain TFIIE_alpha PF02002.12 AIC15519.1 - 0.00048 19.6 0.0 0.00067 19.1 0.0 1.3 1 0 0 1 1 1 1 TFIIE alpha subunit GntR PF00392.16 AIC15519.1 - 0.00077 18.8 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_34 PF13601.1 AIC15519.1 - 0.002 18.1 0.0 0.0031 17.4 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain Fe_dep_repress PF01325.14 AIC15519.1 - 0.008 16.0 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_11 PF08279.7 AIC15519.1 - 0.01 15.4 0.0 0.018 14.6 0.0 1.4 1 0 0 1 1 1 0 HTH domain HTH_29 PF13551.1 AIC15519.1 - 0.017 15.2 0.1 0.031 14.4 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn helix DUF4423 PF14394.1 AIC15519.1 - 0.018 14.6 0.0 0.032 13.7 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4423) HTH_IclR PF09339.5 AIC15519.1 - 0.018 14.5 0.4 0.15 11.7 0.1 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF4393 PF14337.1 AIC15519.1 - 0.035 13.5 0.0 0.073 12.4 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4393) HrcA_DNA-bdg PF03444.10 AIC15519.1 - 0.09 12.2 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HTH_CodY PF08222.6 AIC15519.1 - 0.12 11.7 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 CodY helix-turn-helix domain Pyr_redox_2 PF07992.9 AIC15520.1 - 5.1e-20 72.2 0.0 6.2e-20 71.9 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.19 AIC15520.1 - 3.4e-07 29.5 2.4 0.012 14.5 0.1 3.2 2 1 1 3 3 3 3 FAD dependent oxidoreductase FAD_binding_2 PF00890.19 AIC15520.1 - 1.2e-06 27.7 1.4 2e-05 23.6 0.2 2.8 1 1 1 3 3 3 1 FAD binding domain HI0933_like PF03486.9 AIC15520.1 - 3.1e-06 25.9 0.6 0.0018 16.8 0.4 2.3 1 1 1 2 2 2 2 HI0933-like protein Pyr_redox_3 PF13738.1 AIC15520.1 - 2.3e-05 24.5 1.6 0.21 11.6 0.0 2.4 2 1 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.2 AIC15520.1 - 0.0013 17.9 1.0 0.0013 17.9 0.7 1.5 2 0 0 2 2 2 1 FAD dependent oxidoreductase NAD_binding_9 PF13454.1 AIC15520.1 - 0.005 16.6 2.3 2.4 7.8 0.0 3.1 3 0 0 3 3 3 2 FAD-NAD(P)-binding Lycopene_cycl PF05834.7 AIC15520.1 - 0.013 14.4 0.2 0.13 11.1 0.2 2.1 2 0 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.17 AIC15520.1 - 0.029 13.2 2.0 0.19 10.5 0.2 2.4 3 0 0 3 3 3 0 Glucose inhibited division protein A Thi4 PF01946.12 AIC15520.1 - 0.033 13.2 0.1 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Thi4 family TGT_C2 PF14810.1 AIC15520.1 - 0.086 12.6 0.1 13 5.6 0.0 2.5 2 0 0 2 2 2 0 Patch-forming domain C2 of tRNA-guanine transglycosylase FAD_binding_3 PF01494.14 AIC15520.1 - 0.099 11.6 0.1 0.15 11.1 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain DUF1697 PF08002.6 AIC15521.1 - 1.5e-37 128.6 0.0 1.8e-37 128.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1697) Inhibitor_I36 PF03995.8 AIC15522.1 - 0.13 12.6 0.6 2.3 8.6 0.0 2.9 3 0 0 3 3 3 0 Peptidase inhibitor family I36 PKD PF00801.15 AIC15523.1 - 0.0011 18.7 1.1 0.0011 18.7 0.7 2.3 2 0 0 2 2 2 1 PKD domain Cna_B PF05738.8 AIC15523.1 - 0.029 14.1 0.0 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 Cna protein B-type domain DUF4064 PF13273.1 AIC15524.1 - 1.4 9.0 21.0 1.9 8.6 9.1 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Fork_head_N PF08430.7 AIC15524.1 - 6.2 7.2 11.8 8.3 6.8 8.2 1.3 1 0 0 1 1 1 0 Forkhead N-terminal region DUF973 PF06157.6 AIC15524.1 - 8.6 5.2 11.9 3 6.7 3.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF973) E1-E2_ATPase PF00122.15 AIC15525.1 - 2.4e-57 193.6 2.2 2.8e-57 193.4 0.6 1.8 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.21 AIC15525.1 - 4.1e-53 180.9 9.1 1e-52 179.6 4.0 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AIC15525.1 - 1.8e-19 70.6 0.0 4.1e-19 69.4 0.0 1.7 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AIC15525.1 - 4.1e-07 29.8 1.9 0.006 16.1 0.2 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase YHS PF04945.8 AIC15525.1 - 0.00036 20.3 0.2 0.00075 19.3 0.1 1.4 1 0 0 1 1 1 1 YHS domain Hydrolase_6 PF13344.1 AIC15525.1 - 0.0032 17.3 0.0 0.015 15.1 0.0 2.2 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase DUF2116 PF09889.4 AIC15525.1 - 0.094 12.5 0.0 0.33 10.7 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) HAD_2 PF13419.1 AIC15525.1 - 0.15 12.3 0.0 4.3 7.5 0.0 3.0 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase zf-FCS PF06467.9 AIC15525.1 - 0.15 11.7 0.1 0.26 10.9 0.1 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif HMA PF00403.21 AIC15526.1 - 2.5e-12 46.7 0.5 3.1e-12 46.4 0.4 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain DUF2963 PF11178.3 AIC15526.1 - 0.02 14.2 1.5 0.026 13.9 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2963) YHS PF04945.8 AIC15527.1 - 9.5e-12 44.5 0.2 1.1e-11 44.4 0.1 1.0 1 0 0 1 1 1 1 YHS domain DEAD PF00270.24 AIC15529.1 - 1.2e-49 168.0 0.1 2.5e-48 163.7 0.0 2.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AIC15529.1 - 1.4e-28 98.5 0.1 3.4e-28 97.3 0.1 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF1253 PF06862.7 AIC15529.1 - 8e-05 21.2 0.0 0.2 10.0 0.0 2.9 2 1 0 2 2 2 2 Protein of unknown function (DUF1253) AAA_30 PF13604.1 AIC15529.1 - 0.00036 20.1 0.4 0.66 9.5 0.0 2.6 2 1 0 2 2 2 2 AAA domain SNF2_N PF00176.18 AIC15529.1 - 0.0016 17.3 0.0 0.0026 16.6 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 AIC15529.1 - 0.0027 17.5 0.0 0.0067 16.2 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.1 AIC15529.1 - 0.023 13.7 0.1 0.044 12.8 0.0 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Helicase_C_2 PF13307.1 AIC15529.1 - 0.03 14.2 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain AAA_19 PF13245.1 AIC15529.1 - 0.14 11.9 1.3 4.7 7.0 0.0 3.0 3 0 0 3 3 3 0 Part of AAA domain Radical_SAM PF04055.16 AIC15532.1 - 4.6e-18 65.9 0.0 1.1e-17 64.6 0.0 1.7 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 AIC15532.1 - 9.1e-09 35.5 0.0 2.4e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPASM PF13186.1 AIC15532.1 - 3.7e-08 33.5 1.8 1e-07 32.1 1.2 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_14 PF13394.1 AIC15532.1 - 2.7e-05 24.1 0.8 8.2e-05 22.6 0.0 2.2 2 0 0 2 2 2 1 4Fe-4S single cluster domain Peptidase_U32 PF01136.14 AIC15532.1 - 0.067 12.1 0.1 0.5 9.2 0.0 2.3 3 0 0 3 3 3 0 Peptidase family U32 PqqD PF05402.7 AIC15533.1 - 0.0066 16.4 0.0 0.0096 15.9 0.0 1.4 1 1 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) Radical_SAM PF04055.16 AIC15534.1 - 1.1e-19 71.2 0.1 1.8e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 AIC15534.1 - 1.3e-05 25.3 0.0 2.4e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPASM PF13186.1 AIC15534.1 - 0.0031 17.8 4.5 0.0064 16.7 3.1 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_14 PF13394.1 AIC15534.1 - 0.031 14.3 0.0 0.031 14.3 0.0 2.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain SnoaL_2 PF12680.2 AIC15535.1 - 1.8e-12 47.5 0.0 2.4e-12 47.1 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 AIC15535.1 - 1.2e-06 28.6 0.0 1.6e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) NTF2 PF02136.15 AIC15535.1 - 4e-05 23.9 0.0 5.2e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Fer4_7 PF12838.2 AIC15536.1 - 2.8e-12 46.8 24.6 1.6e-07 31.5 5.7 1.9 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.22 AIC15536.1 - 2e-11 42.9 13.1 2.5e-07 30.0 1.7 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 AIC15536.1 - 6.8e-09 35.6 19.0 2.5e-05 24.1 4.3 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.1 AIC15536.1 - 8.5e-09 35.5 4.9 1.4e-08 34.8 3.4 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 AIC15536.1 - 2e-07 30.6 16.5 6.5e-06 25.8 4.6 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.2 AIC15536.1 - 1.1e-06 28.1 13.6 8.4e-05 22.2 1.4 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_18 PF13746.1 AIC15536.1 - 2.5e-06 27.7 2.3 0.023 15.1 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 AIC15536.1 - 7.8e-06 26.1 0.7 0.11 12.8 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.2 AIC15536.1 - 1.1e-05 25.0 10.7 0.0011 18.7 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.1 AIC15536.1 - 3.2e-05 23.6 7.2 0.00039 20.2 5.3 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.2 AIC15536.1 - 4.3e-05 23.5 6.7 0.012 15.8 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_3 PF12798.2 AIC15536.1 - 0.00012 22.3 13.2 0.012 16.1 1.2 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.1 AIC15536.1 - 0.0016 18.9 10.9 0.0037 17.7 0.8 2.2 1 1 1 2 2 2 1 4Fe-4S single cluster domain Fer4_16 PF13484.1 AIC15536.1 - 0.0017 19.0 7.3 0.23 12.2 1.1 2.3 2 1 1 3 3 3 3 4Fe-4S double cluster binding domain Fer4_13 PF13370.1 AIC15536.1 - 0.03 14.7 8.4 0.27 11.6 0.4 2.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain Diphthamide_syn PF01866.12 AIC15537.1 - 7.8e-69 232.2 0.1 9.6e-69 231.9 0.1 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein ssDNA-exonuc_C PF10141.4 AIC15538.1 - 0.018 14.5 0.4 0.02 14.4 0.3 1.0 1 0 0 1 1 1 0 Single-strand DNA-specific exonuclease, C terminal domain Cys_rich_CPCC PF14206.1 AIC15539.1 - 0.013 15.0 1.2 0.06 12.9 0.2 2.1 2 0 0 2 2 2 0 Cysteine-rich CPCC UbiD PF01977.11 AIC15541.1 - 1e-107 360.1 0.8 1.2e-107 359.9 0.6 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DUF218 PF02698.12 AIC15543.1 - 0.049 13.1 0.0 0.067 12.6 0.0 1.2 1 0 0 1 1 1 0 DUF218 domain IlvN PF07991.7 AIC15543.1 - 0.12 11.7 0.1 0.27 10.5 0.0 1.6 2 0 0 2 2 2 0 Acetohydroxy acid isomeroreductase, catalytic domain HxlR PF01638.12 AIC15545.1 - 8.4e-26 89.4 0.1 1.1e-25 89.0 0.0 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.9 AIC15545.1 - 0.048 13.4 0.0 0.067 12.9 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family DUF505 PF04458.7 AIC15545.1 - 0.14 10.2 0.0 0.14 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) EutH PF04346.7 AIC15546.1 - 0.00028 19.9 1.8 0.00032 19.7 1.2 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein, EutH CopD PF05425.8 AIC15546.1 - 1 9.5 8.0 0.06 13.5 1.6 1.7 2 0 0 2 2 2 0 Copper resistance protein D 2TM PF13239.1 AIC15546.1 - 6.6 6.8 8.0 5 7.2 0.1 2.8 2 1 1 3 3 3 0 2TM domain LEA_2 PF03168.8 AIC15547.1 - 0.0012 19.1 0.1 0.0041 17.4 0.0 2.0 2 1 0 2 2 2 1 Late embryogenesis abundant protein 5TM-5TMR_LYT PF07694.7 AIC15547.1 - 0.042 13.1 0.4 0.057 12.7 0.3 1.2 1 0 0 1 1 1 0 5TMR of 5TMR-LYT DUF2393 PF09624.5 AIC15547.1 - 0.12 11.8 0.0 0.13 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) CopD PF05425.8 AIC15548.1 - 1.7e-14 53.8 7.3 1.7e-14 53.8 5.1 1.7 2 0 0 2 2 2 1 Copper resistance protein D DUF2269 PF10027.4 AIC15548.1 - 0.0069 16.1 10.2 0.0085 15.8 7.1 1.1 1 0 0 1 1 1 1 Predicted integral membrane protein (DUF2269) DUF4149 PF13664.1 AIC15548.1 - 0.045 13.8 8.9 0.58 10.2 6.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) DUF989 PF06181.6 AIC15548.1 - 0.08 12.0 0.3 0.08 12.0 0.2 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF989) DUF1035 PF06281.7 AIC15548.1 - 0.67 9.7 4.8 0.14 11.9 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1035) UPF0093 PF03653.8 AIC15548.1 - 1.9 8.4 5.7 3.2 7.6 3.9 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0093) RTC PF01137.16 AIC15549.1 - 2.1e-70 236.0 0.0 2.5e-70 235.8 0.0 1.0 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.8 AIC15549.1 - 1.8e-12 47.1 0.1 3.5e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Bac_luciferase PF00296.15 AIC15550.1 - 8e-55 186.1 0.0 9.5e-55 185.8 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase DUF4116 PF13475.1 AIC15551.1 - 0.085 12.3 0.0 0.092 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) Fic PF02661.13 AIC15552.1 - 4.4e-06 27.3 0.0 1.7e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 Fic/DOC family DUF1002 PF06207.6 AIC15552.1 - 0.064 12.5 0.7 0.085 12.1 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) CTP_transf_2 PF01467.21 AIC15555.1 - 2.6e-19 69.8 0.4 2.6e-19 69.8 0.2 2.1 1 1 1 2 2 2 1 Cytidylyltransferase RHH_2 PF03693.9 AIC15556.1 - 0.056 13.6 0.0 0.75 10.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0156) Prominin PF05478.6 AIC15557.1 - 0.032 11.7 0.0 0.039 11.4 0.0 1.0 1 0 0 1 1 1 0 Prominin Asparaginase PF00710.15 AIC15558.1 - 1.4e-87 293.5 1.5 1.9e-87 293.0 1.0 1.1 1 0 0 1 1 1 1 Asparaginase DJ-1_PfpI PF01965.19 AIC15558.1 - 0.073 12.5 0.0 0.45 9.9 0.0 2.2 2 0 0 2 2 2 0 DJ-1/PfpI family GatB_N PF02934.10 AIC15559.1 - 3.8e-72 242.5 0.0 5.1e-72 242.1 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 AIC15559.1 - 3.4e-21 75.5 3.3 3.4e-21 75.5 2.3 2.3 2 0 0 2 2 2 1 GatB domain GAD PF02938.9 AIC15559.1 - 4.5e-07 29.9 0.0 1.4e-06 28.3 0.0 2.0 1 0 0 1 1 1 1 GAD domain YqeY PF09424.5 AIC15559.1 - 0.00016 21.5 1.8 0.00016 21.5 1.3 1.9 2 0 0 2 2 2 1 Yqey-like protein Rsbr_N PF08678.5 AIC15560.1 - 0.051 13.4 0.0 0.73 9.7 0.0 2.0 1 1 1 2 2 2 0 Rsbr N terminal Borrelia_P13 PF05628.7 AIC15563.1 - 0.12 12.1 0.3 0.24 11.1 0.1 1.6 1 1 1 2 2 2 0 Borrelia membrane protein P13 FixG_C PF11614.3 AIC15564.1 - 0.0021 18.1 0.5 0.16 12.1 0.0 2.4 1 1 1 2 2 2 1 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF4232 PF14016.1 AIC15564.1 - 0.0026 17.3 0.8 0.2 11.2 0.1 2.5 1 1 0 2 2 2 1 Protein of unknown function (DUF4232) DUF1034 PF06280.7 AIC15564.1 - 0.0082 16.5 0.1 0.015 15.7 0.1 1.5 1 0 0 1 1 1 1 Fn3-like domain (DUF1034) NPCBM_assoc PF10633.4 AIC15564.1 - 0.017 15.1 3.4 1.3 9.1 0.2 3.7 3 1 1 4 4 4 0 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF824 PF05688.6 AIC15564.1 - 0.059 13.0 2.8 1.8 8.2 0.0 3.1 3 0 0 3 3 3 0 Salmonella repeat of unknown function (DUF824) Big_3_4 PF13754.1 AIC15564.1 - 9.8 6.5 8.6 2e+02 2.3 6.0 2.5 1 1 0 1 1 1 0 Bacterial Ig-like domain (group 3) DUF3971 PF13116.1 AIC15565.1 - 0.11 11.7 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function He_PIG PF05345.7 AIC15565.1 - 0.14 12.1 0.1 0.21 11.6 0.1 1.2 1 0 0 1 1 1 0 Putative Ig domain Abi PF02517.11 AIC15566.1 - 1.9e-06 27.8 7.0 2.3e-06 27.6 4.0 1.8 2 0 0 2 2 2 1 CAAX protease self-immunity Neocarzinostat PF00960.13 AIC15566.1 - 0.0062 16.4 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 Neocarzinostatin family HTH_34 PF13601.1 AIC15567.1 - 0.00013 21.8 0.0 0.00084 19.3 0.0 2.1 2 1 0 2 2 2 1 Winged helix DNA-binding domain HTH_27 PF13463.1 AIC15567.1 - 0.00031 21.0 0.0 0.0006 20.0 0.0 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_45 PF14947.1 AIC15567.1 - 0.00047 19.9 0.0 0.0015 18.2 0.0 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix TrmB PF01978.14 AIC15567.1 - 0.0033 17.1 0.1 0.0077 15.9 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC15567.1 - 0.0055 16.0 0.0 0.013 14.9 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.17 AIC15567.1 - 0.0059 16.2 0.0 0.016 14.9 0.0 1.7 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.2 AIC15567.1 - 0.028 14.0 0.0 0.055 13.1 0.0 1.6 1 0 0 1 1 1 0 MarR family Rio2_N PF09202.6 AIC15567.1 - 0.028 14.4 0.0 0.059 13.4 0.0 1.6 1 1 0 1 1 1 0 Rio2, N-terminal Rrf2 PF02082.15 AIC15567.1 - 0.12 12.5 0.1 0.34 11.0 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator zf-ZPR1 PF03367.8 AIC15568.1 - 0.099 11.8 0.2 0.15 11.1 0.2 1.2 1 0 0 1 1 1 0 ZPR1 zinc-finger domain NurA PF09376.5 AIC15569.1 - 3.1e-11 43.2 0.2 1.1e-08 34.8 0.1 2.1 2 0 0 2 2 2 2 NurA domain AAA_10 PF12846.2 AIC15570.1 - 1.7e-15 57.2 0.2 3.2e-07 30.1 0.0 2.2 1 1 0 2 2 2 2 AAA-like domain DUF87 PF01935.12 AIC15570.1 - 1.4e-07 31.5 0.0 3e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 Domain of unknown function DUF87 AAA_17 PF13207.1 AIC15570.1 - 0.00081 20.2 0.0 0.24 12.2 0.0 3.1 3 0 0 3 3 3 1 AAA domain MobB PF03205.9 AIC15570.1 - 0.024 14.3 0.4 0.074 12.7 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_22 PF13401.1 AIC15570.1 - 0.045 13.8 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 AAA domain CbiA PF01656.18 AIC15570.1 - 0.048 13.0 0.0 0.082 12.2 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_29 PF13555.1 AIC15570.1 - 0.051 13.1 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.1 AIC15570.1 - 0.067 13.0 0.1 0.27 11.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain KTI12 PF08433.5 AIC15570.1 - 0.095 11.8 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 P-II PF00543.17 AIC15571.1 - 6.8e-22 77.8 0.8 8.1e-22 77.6 0.6 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II LTD PF00932.14 AIC15572.1 - 4.2e-10 39.7 0.6 8.6e-10 38.7 0.1 1.8 2 0 0 2 2 2 1 Lamin Tail Domain SNase PF00565.12 AIC15572.1 - 0.035 14.3 0.0 0.081 13.1 0.0 1.6 1 0 0 1 1 1 0 Staphylococcal nuclease homologue Corona_6B_7B PF03262.8 AIC15572.1 - 0.092 11.9 0.1 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Coronavirus 6B/7B protein DUF1469 PF07332.6 AIC15573.1 - 0.0033 17.1 8.6 0.0034 17.1 6.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1469) DUF2910 PF11139.3 AIC15573.1 - 0.013 14.6 3.7 0.015 14.4 2.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2910) Chromate_transp PF02417.10 AIC15573.1 - 0.061 12.9 3.9 0.07 12.7 2.7 1.0 1 0 0 1 1 1 0 Chromate transporter NfeD PF01957.13 AIC15573.1 - 0.28 11.2 5.1 0.32 11.1 3.6 1.0 1 0 0 1 1 1 0 NfeD-like C-terminal, partner-binding Trp_oprn_chp PF09534.5 AIC15573.1 - 0.73 9.4 8.4 0.85 9.2 5.8 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) YwiC PF14256.1 AIC15573.1 - 0.81 9.7 7.6 0.93 9.5 5.3 1.1 1 0 0 1 1 1 0 YwiC-like protein DUF4175 PF13779.1 AIC15573.1 - 1.2 6.7 5.6 1.2 6.7 3.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ETRAMP PF09716.5 AIC15573.1 - 4.3 7.3 5.2 8.8 6.3 3.6 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF1206 PF06724.6 AIC15573.1 - 6.2 6.6 7.4 1.2 8.9 0.3 2.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1206) Glycos_transf_4 PF00953.16 AIC15574.1 - 4.1e-26 91.6 15.0 4.1e-26 91.6 10.4 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 4 DEAD PF00270.24 AIC15575.1 - 1.9e-25 89.3 0.0 3.6e-25 88.3 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AIC15575.1 - 7.4e-11 41.7 0.0 1.6e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.1 AIC15575.1 - 3.3e-09 36.7 3.5 1.4e-08 34.7 0.5 2.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain ResIII PF04851.10 AIC15575.1 - 1.7e-05 24.7 0.0 0.00052 19.8 0.0 2.4 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit HHH_2 PF12826.2 AIC15575.1 - 0.00021 21.0 0.1 0.00082 19.2 0.0 2.1 2 0 0 2 2 1 1 Helix-hairpin-helix motif HHH PF00633.18 AIC15575.1 - 0.0015 18.1 3.7 0.58 9.9 0.1 3.5 3 0 0 3 3 3 2 Helix-hairpin-helix motif AAA_19 PF13245.1 AIC15575.1 - 0.0039 16.9 3.6 0.011 15.4 0.4 3.2 3 1 0 3 3 3 1 Part of AAA domain DNA_pol_lambd_f PF10391.4 AIC15575.1 - 0.022 14.3 0.0 0.062 12.8 0.0 1.7 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda RecA PF00154.16 AIC15575.1 - 0.031 13.3 0.1 0.055 12.5 0.0 1.3 1 0 0 1 1 1 0 recA bacterial DNA recombination protein KaiC PF06745.8 AIC15575.1 - 0.035 13.2 0.0 0.082 12.0 0.0 1.5 1 0 0 1 1 1 0 KaiC AAA_26 PF13500.1 AIC15575.1 - 0.036 13.6 0.1 0.065 12.8 0.1 1.4 1 0 0 1 1 1 0 AAA domain DUF4157 PF13699.1 AIC15576.1 - 0.041 14.0 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) LigD_N PF13298.1 AIC15576.1 - 0.057 13.5 0.0 0.12 12.4 0.0 1.5 1 1 0 1 1 1 0 DNA polymerase Ligase (LigD) Peptidase_MA_2 PF13485.1 AIC15576.1 - 0.083 12.9 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase MA superfamily MCM PF00493.18 AIC15577.1 - 2.5e-124 414.3 0.2 3.3e-124 413.9 0.1 1.1 1 0 0 1 1 1 1 MCM2/3/5 family MCM_N PF14551.1 AIC15577.1 - 7.6e-20 71.6 1.0 2.1e-19 70.2 0.2 2.1 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.16 AIC15577.1 - 9.3e-07 28.2 0.1 0.00023 20.3 0.0 2.6 2 1 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.9 AIC15577.1 - 1.1e-06 28.4 0.0 9e-06 25.4 0.0 2.6 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 AIC15577.1 - 0.0015 18.1 0.0 0.0061 16.1 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sld5 PF05916.6 AIC15578.1 - 4.7e-05 23.6 0.0 6.8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 GINS complex protein DNA_pol3_delta2 PF13177.1 AIC15579.1 - 6.9e-17 61.5 0.0 7e-16 58.3 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.24 AIC15579.1 - 8e-14 51.9 0.0 1.6e-13 51.0 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 AIC15579.1 - 3.3e-10 39.2 0.1 3.1e-07 29.4 0.0 2.1 1 1 0 2 2 2 2 Rad17 cell cycle checkpoint protein Rep_fac_C PF08542.6 AIC15579.1 - 9.7e-09 35.1 0.1 4.1e-08 33.0 0.0 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain RuvB_N PF05496.7 AIC15579.1 - 1.5e-07 30.7 0.1 3.4e-07 29.5 0.0 1.6 2 0 0 2 2 2 1 Holliday junction DNA helicase ruvB N-terminus AAA_14 PF13173.1 AIC15579.1 - 1.8e-06 27.8 0.0 3.4e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.1 AIC15579.1 - 3.4e-06 27.2 0.3 6.8e-05 23.0 0.2 2.3 1 1 0 1 1 1 1 AAA domain DEAD PF00270.24 AIC15579.1 - 0.00011 21.7 0.2 0.11 11.9 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase AAA_16 PF13191.1 AIC15579.1 - 0.00021 21.3 0.1 0.031 14.2 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain Mg_chelatase PF01078.16 AIC15579.1 - 0.00028 20.1 0.0 0.065 12.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_10 PF12846.2 AIC15579.1 - 0.00034 20.1 1.7 0.12 11.7 0.0 2.5 1 1 0 2 2 2 2 AAA-like domain DNA_pol3_delta PF06144.8 AIC15579.1 - 0.0008 18.9 0.0 0.0017 17.8 0.0 1.5 2 0 0 2 2 1 1 DNA polymerase III, delta subunit ArgK PF03308.11 AIC15579.1 - 0.002 16.9 0.2 0.0057 15.4 0.1 1.8 1 1 0 1 1 1 1 ArgK protein TIP49 PF06068.8 AIC15579.1 - 0.0027 16.5 0.2 0.075 11.7 0.0 2.5 2 1 0 2 2 2 1 TIP49 C-terminus AAA_19 PF13245.1 AIC15579.1 - 0.0036 17.0 0.0 0.0094 15.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain Arch_ATPase PF01637.13 AIC15579.1 - 0.0043 16.7 0.0 0.24 11.0 0.0 2.2 1 1 1 2 2 2 2 Archaeal ATPase ResIII PF04851.10 AIC15579.1 - 0.0081 16.0 0.0 0.26 11.0 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit NB-ARC PF00931.17 AIC15579.1 - 0.011 14.6 0.0 0.017 14.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_2 PF07724.9 AIC15579.1 - 0.011 15.6 0.0 0.033 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) PhoH PF02562.11 AIC15579.1 - 0.013 14.7 0.1 2.6 7.2 0.0 2.5 2 0 0 2 2 2 0 PhoH-like protein AAA_5 PF07728.9 AIC15579.1 - 0.019 14.7 0.2 0.062 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.21 AIC15579.1 - 0.028 13.9 0.1 0.47 9.9 0.0 2.4 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.1 AIC15579.1 - 0.03 14.6 0.0 0.13 12.5 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.1 AIC15579.1 - 0.051 13.1 0.5 0.22 11.0 0.4 2.0 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 AIC15579.1 - 0.062 14.1 0.0 0.15 12.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.4 AIC15579.1 - 0.069 12.1 0.1 0.26 10.2 0.1 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_25 PF13481.1 AIC15579.1 - 0.11 11.8 0.2 0.3 10.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 AIC15579.1 - 0.13 11.7 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DUF2296 PF10058.4 AIC15580.1 - 0.002 17.8 0.4 0.0045 16.6 0.3 1.6 1 1 0 1 1 1 1 Predicted integral membrane metal-binding protein (DUF2296) zinc_ribbon_5 PF13719.1 AIC15580.1 - 0.0022 17.5 0.6 0.28 10.8 0.1 2.3 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC15580.1 - 0.0028 17.3 0.6 0.44 10.2 0.1 2.3 2 0 0 2 2 2 1 zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 AIC15580.1 - 0.01 15.5 0.1 0.017 14.7 0.1 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain tRNA-synt_1f PF01921.13 AIC15580.1 - 0.016 13.8 0.0 0.021 13.5 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) C1_1 PF00130.17 AIC15580.1 - 0.023 14.3 0.3 0.036 13.7 0.2 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CHY PF05495.7 AIC15580.1 - 0.034 14.3 0.1 0.054 13.6 0.1 1.3 1 0 0 1 1 1 0 CHY zinc finger Nudix_N_2 PF14803.1 AIC15580.1 - 0.034 13.8 1.0 1.9 8.2 0.1 2.2 2 0 0 2 2 2 0 Nudix N-terminal zf-ribbon_3 PF13248.1 AIC15580.1 - 0.053 12.7 1.7 0.43 9.8 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 AIC15580.1 - 0.066 12.5 5.7 3.2 7.1 0.0 2.9 2 1 0 2 2 2 0 TFIIB zinc-binding zf-C3HC4_3 PF13920.1 AIC15580.1 - 0.08 12.6 0.2 0.12 12.0 0.1 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn-ribbon_8 PF09723.5 AIC15580.1 - 0.093 12.6 2.9 0.81 9.6 1.8 2.3 1 1 1 2 2 2 0 Zinc ribbon domain TFIIS_C PF01096.13 AIC15580.1 - 0.098 12.3 1.9 4.3 7.0 0.1 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) CpXC PF14353.1 AIC15580.1 - 0.099 12.6 2.1 1.2 9.1 0.1 2.3 1 1 1 2 2 2 0 CpXC protein zf-C2H2 PF00096.21 AIC15580.1 - 0.1 12.9 1.3 17 6.0 0.0 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type HypA PF01155.14 AIC15580.1 - 0.11 12.2 0.5 0.21 11.3 0.3 1.7 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Elf1 PF05129.8 AIC15580.1 - 0.11 12.2 1.6 8.2 6.1 0.1 2.0 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like zf-C2H2_4 PF13894.1 AIC15580.1 - 0.11 12.8 0.5 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger DZR PF12773.2 AIC15580.1 - 0.16 11.8 1.1 0.54 10.1 0.8 1.8 1 1 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.1 AIC15580.1 - 0.16 11.4 1.2 2.1 7.9 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin PF00301.15 AIC15580.1 - 0.2 11.5 3.3 0.74 9.7 0.1 2.6 3 0 0 3 3 3 0 Rubredoxin zf-H2C2_2 PF13465.1 AIC15580.1 - 0.23 11.8 4.4 3.5 8.0 0.3 2.3 1 1 1 2 2 2 0 Zinc-finger double domain zf-C2H2_6 PF13912.1 AIC15580.1 - 0.24 11.3 1.8 7.5 6.6 0.1 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger Prim_Zn_Ribbon PF08273.7 AIC15580.1 - 0.34 11.0 2.3 14 5.8 0.4 2.3 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase DUF1610 PF07754.6 AIC15580.1 - 0.42 10.7 0.1 0.42 10.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) zf-Mss51 PF13824.1 AIC15580.1 - 1.4 8.8 4.6 5.8 6.8 3.2 2.2 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Pirin PF02678.11 AIC15581.1 - 3.2e-37 126.6 0.2 8.3e-37 125.3 0.1 1.7 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.8 AIC15581.1 - 2.2e-34 117.6 0.1 2e-32 111.3 0.0 2.9 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Cupin_2 PF07883.6 AIC15581.1 - 2e-08 33.6 4.7 0.00047 19.6 0.1 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.7 AIC15581.1 - 0.00053 19.3 0.8 0.31 10.4 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Patatin PF01734.17 AIC15582.1 - 3.7e-24 85.7 0.0 9e-24 84.5 0.0 1.6 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3734 PF12536.3 AIC15582.1 - 1.8e-05 24.8 0.4 7.5e-05 22.8 0.2 2.0 1 1 0 1 1 1 1 Patatin phospholipase DUF3343 PF11823.3 AIC15582.1 - 0.1 11.8 0.0 2.9 7.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) PseudoU_synth_2 PF00849.17 AIC15582.1 - 0.12 12.2 0.2 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 RNA pseudouridylate synthase FTR1 PF03239.9 AIC15583.1 - 9.1e-20 70.8 31.5 3.7e-17 62.2 12.1 3.1 3 1 1 4 4 4 2 Iron permease FTR1 family Dynactin PF12455.3 AIC15583.1 - 0.016 14.1 0.0 0.037 12.9 0.0 1.6 1 0 0 1 1 1 0 Dynein associated protein Ribosomal_S7 PF00177.16 AIC15584.1 - 2.8e-38 130.8 2.4 4.3e-38 130.2 1.7 1.3 1 1 0 1 1 1 1 Ribosomal protein S7p/S5e Ribosom_S12_S23 PF00164.20 AIC15585.1 - 1.3e-39 134.3 0.2 1.6e-39 134.1 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S12/S23 KH_2 PF07650.12 AIC15586.1 - 1.5e-22 78.9 1.4 8.2e-15 54.1 0.1 2.1 2 0 0 2 2 2 2 KH domain KH_5 PF13184.1 AIC15586.1 - 6e-11 41.9 2.7 6.7e-10 38.6 0.1 2.2 2 0 0 2 2 2 1 NusA-like KH domain KH_4 PF13083.1 AIC15586.1 - 9.2e-11 41.2 0.8 0.00042 19.9 0.0 2.2 2 0 0 2 2 2 2 KH domain KH_1 PF00013.24 AIC15586.1 - 3.8e-09 36.0 0.5 3e-05 23.5 0.1 2.4 2 0 0 2 2 2 2 KH domain KH_3 PF13014.1 AIC15586.1 - 0.013 15.1 0.3 0.013 15.1 0.2 2.5 3 0 0 3 3 3 0 KH domain DUF3979 PF13141.1 AIC15586.1 - 0.066 13.1 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3979) Ribosomal_L7Ae PF01248.21 AIC15587.1 - 2e-10 40.0 1.8 2.4e-10 39.7 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PYNP_C PF07831.8 AIC15587.1 - 0.029 13.8 0.0 0.05 13.0 0.0 1.4 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain RNA_pol_Rpb1_5 PF04998.12 AIC15588.1 - 4.9e-86 288.4 0.7 8.2e-86 287.6 0.5 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_1 PF04997.7 AIC15588.1 - 1.3e-83 281.0 0.6 1.7e-81 274.0 0.0 2.8 2 1 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_2 PF00623.15 AIC15588.1 - 4.2e-69 231.7 0.0 1.1e-68 230.3 0.0 1.8 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.13 AIC15588.1 - 2.9e-33 114.8 0.0 6.2e-33 113.7 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.12 AIC15588.1 - 5.6e-25 87.1 0.0 1.4e-24 85.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 TniQ PF06527.6 AIC15588.1 - 0.016 15.4 0.0 2.8 8.1 0.0 2.4 2 0 0 2 2 2 0 TniQ NAC PF01849.13 AIC15588.1 - 0.029 13.8 0.1 0.094 12.2 0.0 1.8 1 0 0 1 1 1 0 NAC domain Bystin PF05291.6 AIC15588.1 - 0.14 11.0 0.0 1.3 7.9 0.0 2.4 2 1 1 3 3 3 0 Bystin DUF164 PF02591.10 AIC15588.1 - 0.77 9.6 2.6 7.4 6.4 0.2 3.0 2 1 1 3 3 3 0 Putative zinc ribbon domain RNA_pol_Rpb2_6 PF00562.23 AIC15589.1 - 9e-120 399.9 0.0 1.3e-119 399.4 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.10 AIC15589.1 - 3.8e-47 159.8 0.0 5.7e-47 159.2 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.15 AIC15589.1 - 2.7e-30 104.4 0.1 5.9e-30 103.3 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.11 AIC15589.1 - 2.3e-27 94.5 0.0 4.3e-27 93.6 0.0 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.9 AIC15589.1 - 2.5e-21 75.9 0.0 4.9e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.8 AIC15589.1 - 4.2e-14 52.1 0.1 1.5e-13 50.3 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.12 AIC15589.1 - 1.5e-13 50.4 0.3 3.4e-13 49.3 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 FYVE PF01363.16 AIC15589.1 - 0.025 14.4 0.1 0.047 13.5 0.1 1.3 1 0 0 1 1 1 0 FYVE zinc finger Zn_Tnp_IS1595 PF12760.2 AIC15589.1 - 0.047 13.5 0.4 0.095 12.5 0.3 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain DUF2318 PF10080.4 AIC15589.1 - 0.11 12.2 0.4 0.25 11.1 0.3 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) OrfB_Zn_ribbon PF07282.6 AIC15589.1 - 0.2 11.3 1.3 0.58 9.8 0.9 1.8 1 0 0 1 1 1 0 Putative transposase DNA-binding domain CAF1-p150_N PF15557.1 AIC15589.1 - 0.26 10.5 0.0 0.45 9.7 0.0 1.3 1 0 0 1 1 1 0 CAF1 complex subunit p150, region binding to PCNA RNA_pol_Rpb5_C PF01191.14 AIC15590.1 - 5e-28 96.5 0.4 5.8e-28 96.3 0.3 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain A2M_N PF01835.14 AIC15591.1 - 4.9e-06 26.7 0.3 1.8e-05 24.9 0.2 1.9 1 1 0 1 1 1 1 MG2 domain DUF1416 PF07210.7 AIC15591.1 - 0.051 13.1 0.2 0.35 10.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1416) Ribosomal_S4e PF00900.15 AIC15591.1 - 0.057 13.0 0.1 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 Ribosomal family S4e DUF1264 PF06884.6 AIC15592.1 - 7.8e-26 90.5 0.0 1.1e-25 90.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) NIF3 PF01784.13 AIC15593.1 - 1.1e-20 74.3 1.4 2.4e-20 73.1 1.0 1.5 1 1 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) ADH_zinc_N PF00107.21 AIC15593.1 - 0.014 14.9 0.5 0.047 13.2 0.3 1.9 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Wyosine_form PF08608.7 AIC15594.1 - 1.5e-18 66.6 0.0 4e-18 65.2 0.0 1.8 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.16 AIC15594.1 - 7.8e-18 65.1 0.1 3.1e-17 63.2 0.1 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.1 AIC15594.1 - 0.0038 17.2 0.1 0.024 14.6 0.1 2.1 1 1 0 1 1 1 1 4Fe-4S single cluster domain NADH_Oxid_Nqo15 PF11497.3 AIC15594.1 - 0.099 12.3 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 NADH-quinone oxidoreductase chain 15 Fer4_12 PF13353.1 AIC15594.1 - 0.15 12.1 0.5 0.5 10.4 0.3 1.8 1 1 0 1 1 1 0 4Fe-4S single cluster domain Ham1p_like PF01725.11 AIC15595.1 - 1.2e-48 164.9 0.0 1.4e-48 164.7 0.0 1.0 1 0 0 1 1 1 1 Ham1 family APH PF01636.18 AIC15596.1 - 2.1e-09 37.4 1.7 1.2e-05 25.2 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.20 AIC15596.1 - 1.9e-05 23.9 0.0 4.8e-05 22.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.17 AIC15596.1 - 2.5e-05 23.6 0.0 4.5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.9 AIC15596.1 - 3.7e-05 22.8 0.0 9.2e-05 21.5 0.0 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 AIC15596.1 - 0.0048 15.8 0.0 0.015 14.2 0.0 1.7 1 1 1 2 2 2 1 Kinase-like Choline_kinase PF01633.15 AIC15596.1 - 0.017 14.7 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.12 AIC15596.1 - 0.024 13.7 0.0 0.031 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase EcKinase PF02958.15 AIC15596.1 - 0.056 12.5 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase bPH_3 PF14470.1 AIC15597.1 - 1.2e-05 25.4 0.0 2.2e-05 24.6 0.0 1.4 1 1 0 1 1 1 1 Bacterial PH domain GRAM PF02893.15 AIC15597.1 - 0.00059 19.3 0.0 0.00086 18.7 0.0 1.2 1 0 0 1 1 1 1 GRAM domain Peptidase_M22 PF00814.20 AIC15598.1 - 3.4e-77 259.5 0.0 4e-77 259.3 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family MMR_HSR1_C PF08438.5 AIC15599.1 - 8e-31 106.4 0.1 1.4e-30 105.7 0.1 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.18 AIC15599.1 - 5.4e-18 65.0 0.0 1.3e-17 63.8 0.0 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase TGS PF02824.16 AIC15599.1 - 5.7e-14 51.7 0.1 2.9e-13 49.4 0.0 2.1 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.13 AIC15599.1 - 6.6e-07 28.7 0.1 3.2e-06 26.5 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B AAA_29 PF13555.1 AIC15599.1 - 0.0079 15.7 0.1 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain YchF-GTPase_C PF06071.8 AIC15599.1 - 0.022 14.5 0.1 0.1 12.3 0.0 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF933) DUF2132 PF09905.4 AIC15599.1 - 0.024 14.6 0.1 0.065 13.1 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2132) YfdX PF10938.3 AIC15599.1 - 0.041 13.5 0.6 0.19 11.3 0.1 2.3 2 1 0 2 2 2 0 YfdX protein Cupin_5 PF06172.6 AIC15600.1 - 9.1e-48 161.7 0.0 1.1e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) QueC PF06508.8 AIC15601.1 - 1e-51 175.1 0.2 1.2e-51 175.0 0.1 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 AIC15601.1 - 3.1e-05 23.5 0.0 4e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase Arginosuc_synth PF00764.14 AIC15601.1 - 0.014 14.4 0.0 0.017 14.1 0.0 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase DUF1814 PF08843.6 AIC15601.1 - 0.021 14.6 0.9 0.03 14.1 0.6 1.3 1 1 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF1814) ThiI PF02568.9 AIC15601.1 - 0.038 13.4 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Mur_ligase_C PF02875.16 AIC15601.1 - 0.094 12.7 0.1 0.22 11.6 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain ApbA_C PF08546.6 AIC15601.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal Fer4_14 PF13394.1 AIC15602.1 - 8.6e-18 64.4 0.1 1.4e-17 63.8 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.16 AIC15602.1 - 6.4e-13 49.2 0.3 8.5e-13 48.8 0.2 1.2 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 AIC15602.1 - 2.2e-12 47.2 0.2 4e-12 46.4 0.1 1.5 1 1 0 1 1 1 1 4Fe-4S single cluster domain RadC PF04002.10 AIC15602.1 - 0.14 11.8 0.0 0.22 11.1 0.0 1.3 1 0 0 1 1 1 0 RadC-like JAB domain GTP_cyclohydroI PF01227.17 AIC15603.1 - 3.3e-61 205.6 0.1 3.8e-61 205.4 0.1 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.1 AIC15603.1 - 0.0033 17.3 0.0 0.0074 16.2 0.0 1.6 2 0 0 2 2 2 1 QueF-like protein CLU PF13236.1 AIC15603.1 - 0.13 11.6 0.0 0.34 10.2 0.0 1.6 2 0 0 2 2 2 0 Clustered mitochondria PepSY PF03413.14 AIC15604.1 - 1e-05 26.0 0.5 2.3e-05 24.9 0.4 1.6 1 1 0 1 1 1 1 Peptidase propeptide and YPEB domain AAA PF00004.24 AIC15606.1 - 4.1e-16 59.3 0.1 1.9e-15 57.2 0.0 2.2 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.10 AIC15606.1 - 3e-09 36.1 0.0 0.00052 18.8 0.0 2.2 2 0 0 2 2 2 2 Rad17 cell cycle checkpoint protein AAA_14 PF13173.1 AIC15606.1 - 5.3e-07 29.5 0.0 1.1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC15606.1 - 8.9e-07 29.7 0.0 2.1e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AIC15606.1 - 2.5e-06 27.6 0.2 0.00026 21.0 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_22 PF13401.1 AIC15606.1 - 3e-06 27.3 0.0 0.00046 20.3 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.9 AIC15606.1 - 1.9e-05 24.4 0.0 4.8e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) RuvB_N PF05496.7 AIC15606.1 - 0.0002 20.4 0.0 0.00041 19.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 AIC15606.1 - 0.00028 20.5 0.0 0.00089 18.9 0.0 1.9 1 0 0 1 1 1 1 Part of AAA domain NACHT PF05729.7 AIC15606.1 - 0.00051 19.7 0.0 0.14 11.8 0.0 2.5 2 0 0 2 2 2 1 NACHT domain ABC_tran PF00005.22 AIC15606.1 - 0.0007 19.9 0.0 0.0014 18.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter IstB_IS21 PF01695.12 AIC15606.1 - 0.00079 18.8 0.0 0.0016 17.9 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_18 PF13238.1 AIC15606.1 - 0.0011 19.2 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AIC15606.1 - 0.0013 18.1 0.0 0.0029 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AIC15606.1 - 0.0015 18.4 0.0 0.0032 17.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.8 AIC15606.1 - 0.0023 16.7 0.0 0.0043 15.8 0.0 1.4 1 0 0 1 1 1 1 TIP49 C-terminus DUF815 PF05673.8 AIC15606.1 - 0.0033 16.3 0.0 0.0053 15.7 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Mg_chelatase PF01078.16 AIC15606.1 - 0.0033 16.5 0.0 0.0069 15.5 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 AIC15606.1 - 0.004 17.1 0.0 0.0078 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain DUF258 PF03193.11 AIC15606.1 - 0.007 15.5 0.0 0.014 14.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 NTPase_1 PF03266.10 AIC15606.1 - 0.0078 15.9 0.0 0.019 14.6 0.0 1.7 1 0 0 1 1 1 1 NTPase RNA_helicase PF00910.17 AIC15606.1 - 0.01 16.0 0.0 0.023 14.8 0.0 1.7 1 1 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.7 AIC15606.1 - 0.016 14.3 0.0 0.027 13.5 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_29 PF13555.1 AIC15606.1 - 0.017 14.6 0.0 0.038 13.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_3 PF07726.6 AIC15606.1 - 0.022 14.3 0.1 0.069 12.7 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.9 AIC15606.1 - 0.037 13.9 0.0 0.095 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NB-ARC PF00931.17 AIC15606.1 - 0.038 12.8 0.0 0.068 12.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activ_2 PF14532.1 AIC15606.1 - 0.072 13.1 0.0 0.21 11.6 0.0 1.9 2 0 0 2 2 1 0 Sigma-54 interaction domain SRP54 PF00448.17 AIC15606.1 - 0.094 12.1 0.0 0.17 11.2 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.18 AIC15606.1 - 0.1 12.5 0.0 0.3 11.0 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_11 PF13086.1 AIC15606.1 - 0.16 11.5 0.0 0.26 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain zf-HC5HC2H_2 PF13832.1 AIC15607.1 - 0.05 13.5 12.3 0.11 12.4 8.4 1.6 1 1 1 2 2 2 0 PHD-zinc-finger like domain Prok-RING_1 PF14446.1 AIC15607.1 - 0.089 12.5 0.2 0.089 12.5 0.1 3.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 ProRS-C_1 PF09180.6 AIC15607.1 - 0.12 12.3 3.9 5.2 7.0 0.0 2.7 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal FBA_3 PF08268.7 AIC15607.1 - 0.15 11.8 0.3 0.21 11.3 0.2 1.2 1 0 0 1 1 1 0 F-box associated domain tRNA-synt_1g PF09334.6 AIC15607.1 - 0.2 10.2 2.0 0.22 10.1 1.4 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (M) DUF2175 PF09943.4 AIC15607.1 - 0.86 9.6 6.7 0.24 11.4 0.7 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) zf-HC5HC2H PF13771.1 AIC15607.1 - 1.9 8.6 14.3 0.41 10.8 6.4 2.1 1 1 1 2 2 2 0 PHD-like zinc-binding domain Vps5 PF09325.5 AIC15608.1 - 0.074 12.2 0.1 0.086 12.0 0.1 1.0 1 0 0 1 1 1 0 Vps5 C terminal like HalX PF08663.5 AIC15608.1 - 0.1 12.6 1.3 0.13 12.2 0.9 1.2 1 0 0 1 1 1 0 HalX domain Carboxyl_trans PF01039.17 AIC15609.1 - 2.1e-190 633.2 0.2 2.4e-190 633.0 0.1 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.6 AIC15609.1 - 2e-06 27.1 0.0 6.9e-06 25.4 0.0 1.8 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) CPSase_L_D2 PF02786.12 AIC15610.1 - 2e-74 249.4 0.0 3.2e-74 248.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_chain PF00289.17 AIC15610.1 - 1.2e-43 147.6 0.7 1.8e-42 143.8 0.1 2.5 3 0 0 3 3 3 1 Carbamoyl-phosphate synthase L chain, N-terminal domain Biotin_carb_C PF02785.14 AIC15610.1 - 7.9e-36 122.3 0.0 1.6e-35 121.2 0.0 1.6 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain ATP-grasp_4 PF13535.1 AIC15610.1 - 4.5e-18 65.6 0.1 9.6e-18 64.5 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 AIC15610.1 - 1.7e-15 56.6 0.1 5.5e-10 38.5 0.0 2.1 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon RimK PF08443.6 AIC15610.1 - 5.6e-10 39.0 0.0 7.1e-07 28.8 0.0 2.3 2 0 0 2 2 2 2 RimK-like ATP-grasp domain Dala_Dala_lig_C PF07478.8 AIC15610.1 - 2.5e-07 30.2 0.0 1e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.17 AIC15610.1 - 6.4e-07 28.8 0.0 1.4e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 AIC15610.1 - 3.7e-05 23.6 0.0 0.00028 20.7 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_YheCD PF14398.1 AIC15610.1 - 0.072 11.8 0.0 0.22 10.2 0.0 1.7 2 0 0 2 2 2 0 YheC/D like ATP-grasp Biotin_lipoyl PF00364.17 AIC15611.1 - 1.4e-16 59.9 4.7 2.1e-16 59.3 2.2 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.1 AIC15611.1 - 1.8e-14 53.1 2.4 3e-10 39.6 0.2 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_2 PF12700.2 AIC15611.1 - 8.5e-05 21.8 2.5 0.1 11.7 0.1 2.5 2 1 1 3 3 3 2 HlyD family secretion protein HlyD PF00529.15 AIC15611.1 - 0.00015 21.2 2.1 0.0067 15.7 0.2 2.1 1 1 1 2 2 2 2 HlyD family secretion protein HlyD_3 PF13437.1 AIC15611.1 - 0.0014 18.8 0.9 1.8 8.9 0.1 2.9 3 1 0 3 3 3 2 HlyD family secretion protein GCV_H PF01597.14 AIC15611.1 - 0.003 17.2 0.7 0.0069 16.0 0.3 1.8 2 0 0 2 2 2 1 Glycine cleavage H-protein PASTA PF03793.14 AIC15611.1 - 0.0043 16.6 0.2 0.013 15.1 0.1 2.0 2 0 0 2 2 2 1 PASTA domain DUF2118 PF09891.4 AIC15611.1 - 0.022 14.4 0.6 0.2 11.3 0.1 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) PYNP_C PF07831.8 AIC15611.1 - 0.072 12.5 0.4 0.74 9.3 0.0 2.3 2 0 0 2 2 2 0 Pyrimidine nucleoside phosphorylase C-terminal domain Fer2_4 PF13510.1 AIC15611.1 - 0.13 12.0 0.0 0.41 10.4 0.0 1.8 2 1 0 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain MFS_1 PF07690.11 AIC15612.1 - 1e-05 24.4 15.0 5.6e-05 22.0 10.4 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_2 PF13347.1 AIC15612.1 - 1.5 7.1 10.7 0.11 10.8 2.1 2.1 2 0 0 2 2 2 0 MFS/sugar transport protein PRA1 PF03208.14 AIC15612.1 - 6.7 6.0 8.9 0.77 9.0 2.4 2.0 2 0 0 2 2 2 0 PRA1 family protein DUF3487 PF11990.3 AIC15612.1 - 9.4 5.6 15.7 11 5.4 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3487) Lactamase_B_2 PF12706.2 AIC15613.1 - 1.4e-15 57.3 0.1 1.7e-15 57.0 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 AIC15613.1 - 2.6e-06 27.2 0.0 3.3e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain AhpC-TSA PF00578.16 AIC15614.1 - 7.7e-39 132.2 0.0 9.8e-39 131.8 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AIC15614.1 - 3.5e-27 94.7 0.0 4.4e-27 94.4 0.0 1.1 1 0 0 1 1 1 1 Redoxin SCO1-SenC PF02630.9 AIC15614.1 - 6.9e-05 22.5 0.0 9e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC TraF PF13728.1 AIC15614.1 - 0.076 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein AhpC-TSA_2 PF13911.1 AIC15614.1 - 0.13 12.1 0.0 3.8 7.4 0.0 2.2 1 1 0 1 1 1 0 AhpC/TSA antioxidant enzyme Aminotran_5 PF00266.14 AIC15615.1 - 2.2e-94 316.2 0.0 2.7e-94 315.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 AIC15615.1 - 4.6e-06 25.9 0.0 6.5e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.12 AIC15615.1 - 0.00046 19.3 0.1 0.00069 18.7 0.1 1.2 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family QueC PF06508.8 AIC15616.1 - 1.1e-10 41.1 0.0 6.1e-09 35.4 0.0 2.5 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.16 AIC15616.1 - 9.9e-09 35.0 0.0 1.4e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 AIC15616.1 - 1.9e-08 33.5 0.0 4.8e-08 32.2 0.0 1.6 2 0 0 2 2 2 1 NAD synthase tRNA_Me_trans PF03054.11 AIC15616.1 - 6.5e-08 31.5 0.0 3.7e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 tRNA methyl transferase ATP_bind_3 PF01171.15 AIC15616.1 - 9.8e-05 21.9 0.1 0.00053 19.5 0.1 2.1 1 1 1 2 2 2 1 PP-loop family ThiI PF02568.9 AIC15616.1 - 0.00014 21.3 0.0 0.00029 20.3 0.0 1.5 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.14 AIC15616.1 - 0.0029 16.7 0.1 0.0042 16.1 0.1 1.3 1 0 0 1 1 1 1 Arginosuccinate synthase Hydrolase_4 PF12146.3 AIC15616.1 - 0.013 15.2 0.0 0.28 11.0 0.0 2.4 2 0 0 2 2 2 0 Putative lysophospholipase AAA_33 PF13671.1 AIC15616.1 - 0.038 13.8 0.0 0.081 12.7 0.0 1.7 1 1 0 1 1 1 0 AAA domain PAPS_reduct PF01507.14 AIC15616.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.5 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DUF111 PF01969.12 AIC15617.1 - 2.2e-110 369.0 2.2 2.5e-110 368.9 1.5 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF111 HypA PF01155.14 AIC15618.1 - 0.042 13.5 0.1 0.051 13.2 0.0 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family CbtA PF09490.5 AIC15621.1 - 0.009 15.3 23.2 0.069 12.4 16.1 2.0 1 1 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) SHOCT PF09851.4 AIC15621.1 - 0.12 11.8 0.6 0.28 10.7 0.4 1.6 1 0 0 1 1 1 0 Short C-terminal domain DUF3054 PF11255.3 AIC15621.1 - 0.12 12.1 0.2 0.12 12.1 0.2 2.6 3 1 0 3 3 3 0 Protein of unknown function (DUF3054) TRAPP PF04051.11 AIC15621.1 - 0.13 11.7 0.1 14 5.1 0.0 2.3 2 0 0 2 2 2 0 Transport protein particle (TRAPP) component Yip1 PF04893.12 AIC15621.1 - 3.7 7.0 22.8 2 7.9 6.0 2.4 1 1 1 2 2 2 0 Yip1 domain Dioxygenase_N PF04444.9 AIC15622.1 - 0.12 12.4 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Catechol dioxygenase N terminus Toxin_9 PF02819.10 AIC15623.1 - 0.0018 18.2 3.8 0.0023 17.9 2.6 1.2 1 0 0 1 1 1 1 Spider toxin TruB_N PF01509.13 AIC15624.1 - 3.9e-24 85.4 0.8 2.5e-20 73.1 0.5 3.2 1 1 0 1 1 1 1 TruB family pseudouridylate synthase (N terminal domain) DKCLD PF08068.7 AIC15624.1 - 2e-14 53.2 0.0 3.9e-14 52.3 0.0 1.5 1 0 0 1 1 1 1 DKCLD (NUC011) domain PUA PF01472.15 AIC15624.1 - 2.5e-14 52.7 0.5 4.6e-14 51.9 0.4 1.5 1 0 0 1 1 1 1 PUA domain Cytidylate_kin2 PF13189.1 AIC15625.1 - 2.4e-16 60.1 0.0 3e-16 59.8 0.0 1.1 1 0 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.1 AIC15625.1 - 9.8e-14 51.7 0.1 1.3e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC15625.1 - 4.4e-09 37.1 0.1 8.5e-09 36.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 AIC15625.1 - 0.0025 17.0 0.0 0.0042 16.3 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.1 AIC15625.1 - 0.0073 16.2 0.2 0.034 14.1 0.1 1.9 1 1 1 2 2 2 1 AAA domain RNA_helicase PF00910.17 AIC15625.1 - 0.0083 16.2 0.0 0.012 15.8 0.0 1.3 1 0 0 1 1 1 1 RNA helicase AAA_14 PF13173.1 AIC15625.1 - 0.0088 15.9 0.0 0.017 15.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AIC15625.1 - 0.0098 15.7 0.0 0.018 14.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA PF00004.24 AIC15625.1 - 0.018 15.2 0.0 0.029 14.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SKI PF01202.17 AIC15625.1 - 0.02 14.7 0.7 0.4 10.5 0.4 2.4 1 1 0 1 1 1 0 Shikimate kinase ADK PF00406.17 AIC15625.1 - 0.029 14.2 0.2 0.076 12.8 0.0 1.7 2 0 0 2 2 2 0 Adenylate kinase AAA_22 PF13401.1 AIC15625.1 - 0.03 14.4 0.0 0.052 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF106 PF01956.11 AIC15626.1 - 2.4e-10 40.1 12.0 5.3e-10 39.0 7.2 2.0 1 1 0 1 1 1 1 Integral membrane protein DUF106 RSN1_TM PF13967.1 AIC15626.1 - 0.00037 20.0 0.1 0.1 12.1 0.0 2.3 2 0 0 2 2 2 2 Late exocytosis, associated with Golgi transport DUF4199 PF13858.1 AIC15626.1 - 0.079 12.8 1.2 0.14 12.0 0.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) PrgI PF12666.2 AIC15626.1 - 0.8 9.8 5.5 0.43 10.7 0.1 2.5 3 0 0 3 3 3 0 PrgI family protein AAA_18 PF13238.1 AIC15627.1 - 3.7e-13 49.8 0.0 5e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC15627.1 - 1.3e-06 29.1 0.0 2.1e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.17 AIC15627.1 - 5.2e-06 26.0 0.1 7.8e-06 25.4 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_28 PF13521.1 AIC15627.1 - 2.3e-05 24.4 0.1 5.8e-05 23.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 AIC15627.1 - 2.8e-05 24.0 0.0 3.7e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AIC15627.1 - 0.00023 20.8 0.7 0.00065 19.4 0.1 2.0 2 0 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 AIC15627.1 - 0.00026 21.1 0.1 0.00047 20.2 0.1 1.5 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 AIC15627.1 - 0.00056 19.1 0.0 0.00072 18.8 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 NTPase_1 PF03266.10 AIC15627.1 - 0.002 17.8 1.4 0.0067 16.1 1.0 1.8 1 1 0 1 1 1 1 NTPase AAA_5 PF07728.9 AIC15627.1 - 0.0036 17.0 0.2 0.0098 15.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_30 PF13604.1 AIC15627.1 - 0.004 16.7 0.5 0.0072 15.9 0.3 1.5 1 1 0 1 1 1 1 AAA domain cobW PF02492.14 AIC15627.1 - 0.0041 16.5 0.0 0.025 14.0 0.1 1.9 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.4 AIC15627.1 - 0.0045 16.0 0.0 0.0049 15.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.1 AIC15627.1 - 0.0075 16.2 0.0 0.0086 16.0 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain MobB PF03205.9 AIC15627.1 - 0.011 15.4 0.4 0.026 14.2 0.3 1.8 1 1 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.24 AIC15627.1 - 0.014 15.6 0.0 0.025 14.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.13 AIC15627.1 - 0.015 14.8 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.16 AIC15627.1 - 0.016 14.3 0.1 0.042 12.9 0.0 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI ATP_bind_1 PF03029.12 AIC15627.1 - 0.025 14.1 0.3 0.29 10.6 0.0 2.3 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.18 AIC15627.1 - 0.032 14.1 0.1 0.062 13.2 0.1 1.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Arch_ATPase PF01637.13 AIC15627.1 - 0.041 13.5 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase ArgK PF03308.11 AIC15627.1 - 0.041 12.6 0.2 0.067 11.9 0.1 1.3 1 0 0 1 1 1 0 ArgK protein AAA_14 PF13173.1 AIC15627.1 - 0.044 13.6 0.1 0.075 12.9 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_24 PF13479.1 AIC15627.1 - 0.047 13.2 0.4 0.083 12.4 0.3 1.6 1 1 0 1 1 1 0 AAA domain ResIII PF04851.10 AIC15627.1 - 0.087 12.6 1.1 0.5 10.1 0.5 1.9 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Miro PF08477.8 AIC15627.1 - 0.1 13.1 0.2 0.15 12.5 0.1 1.5 1 1 0 1 1 1 0 Miro-like protein NACHT PF05729.7 AIC15627.1 - 0.1 12.2 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.17 AIC15627.1 - 0.13 12.4 0.0 0.26 11.5 0.0 1.6 1 1 1 2 2 2 0 RNA helicase AAA_25 PF13481.1 AIC15627.1 - 0.17 11.2 1.2 0.83 9.0 0.8 2.0 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.1 AIC15627.1 - 0.21 11.1 1.3 0.51 9.8 0.9 1.9 1 1 0 1 1 1 0 AAA domain SecY PF00344.15 AIC15628.1 - 4.1e-84 282.4 16.8 5.1e-84 282.1 11.7 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.4 AIC15628.1 - 1.7e-12 46.6 0.5 5.4e-12 45.0 0.4 2.0 1 0 0 1 1 1 1 Plug domain of Sec61p Ribosomal_L18e PF00828.14 AIC15629.1 - 2.4e-21 76.4 1.5 3e-21 76.1 1.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L18e/L15 Ribosomal_L30 PF00327.15 AIC15630.1 - 4.2e-12 45.4 0.0 6.7e-12 44.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_S5 PF00333.15 AIC15631.1 - 6.4e-19 67.4 0.8 1.1e-18 66.7 0.5 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.10 AIC15631.1 - 2.8e-18 64.9 0.1 4.3e-18 64.3 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_L18p PF00861.17 AIC15632.1 - 1.4e-19 70.3 0.3 2.8e-19 69.4 0.2 1.5 1 0 0 1 1 1 1 Ribosomal L18p/L5e family Ribosomal_L18_c PF14204.1 AIC15632.1 - 3.4e-11 43.5 7.8 3.4e-11 43.5 5.4 1.8 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region FliD_C PF07195.7 AIC15632.1 - 0.0033 16.7 0.0 0.0064 15.8 0.0 1.4 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus DUF2058 PF09831.4 AIC15632.1 - 0.45 10.3 8.4 0.89 9.4 5.8 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) RNase_H2-Ydr279 PF09468.5 AIC15632.1 - 0.99 8.5 12.6 1.2 8.2 8.7 1.1 1 0 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) AIRC PF00731.15 AIC15633.1 - 6.7e-22 77.3 8.7 6.7e-22 77.3 6.1 1.6 2 0 0 2 2 2 1 AIR carboxylase CW_binding_2 PF04122.7 AIC15633.1 - 0.064 13.4 2.7 0.12 12.5 0.5 2.4 2 1 0 2 2 2 0 Putative cell wall binding repeat 2 Ldh_1_N PF00056.18 AIC15634.1 - 2.1e-36 124.8 0.8 2.1e-36 124.8 0.6 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.13 AIC15634.1 - 7.7e-26 90.8 0.1 1.1e-25 90.3 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.11 AIC15634.1 - 0.021 14.1 0.3 0.12 11.7 0.1 2.0 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase UDPG_MGDP_dh_N PF03721.9 AIC15634.1 - 0.56 9.5 4.8 0.37 10.1 1.2 2.2 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Herpes_US9 PF06072.6 AIC15635.1 - 0.033 14.0 0.3 0.058 13.2 0.2 1.3 1 0 0 1 1 1 0 Alphaherpesvirus tegument protein US9 YcaO PF02624.11 AIC15636.1 - 8.7e-71 239.1 0.0 2.5e-69 234.3 0.0 2.3 2 1 0 2 2 2 1 YcaO-like family TfuA PF07812.7 AIC15637.1 - 8.4e-31 105.9 0.1 1.4e-30 105.1 0.0 1.4 2 0 0 2 2 2 1 TfuA-like protein Cob_adeno_trans PF01923.13 AIC15638.1 - 2.5e-56 189.9 0.0 2.9e-56 189.7 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase ABC-3 PF00950.12 AIC15639.1 - 0.087 12.0 3.1 0.088 12.0 2.1 1.0 1 0 0 1 1 1 0 ABC 3 transport family zf-C2H2_4 PF13894.1 AIC15640.1 - 7.6e-07 29.0 0.4 9.1e-07 28.7 0.3 1.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC15640.1 - 2.7e-06 27.3 0.7 3.2e-06 27.1 0.5 1.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-Di19 PF05605.7 AIC15640.1 - 3.2e-05 23.9 0.1 3.8e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.2 AIC15640.1 - 0.00062 19.8 0.1 0.00062 19.8 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.1 AIC15640.1 - 0.0026 17.9 2.4 0.22 11.8 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-CHCC PF10276.4 AIC15640.1 - 0.0042 16.8 0.1 0.0054 16.5 0.1 1.2 1 0 0 1 1 1 1 Zinc-finger domain zf-C2H2_jaz PF12171.3 AIC15640.1 - 0.0089 16.1 0.1 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF2225 PF09986.4 AIC15640.1 - 0.012 15.0 0.0 0.012 15.0 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-BED PF02892.10 AIC15640.1 - 0.019 14.7 0.1 0.026 14.2 0.1 1.3 1 0 0 1 1 1 0 BED zinc finger HNH PF01844.18 AIC15640.1 - 0.024 14.5 0.2 0.029 14.2 0.2 1.2 1 0 0 1 1 1 0 HNH endonuclease zf-ribbon_3 PF13248.1 AIC15640.1 - 0.024 13.8 0.1 0.03 13.5 0.1 1.2 1 0 0 1 1 1 0 zinc-ribbon domain PyrI_C PF02748.10 AIC15640.1 - 0.042 13.2 0.1 0.049 13.0 0.1 1.2 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2HC_2 PF13913.1 AIC15640.1 - 0.051 13.2 0.6 0.076 12.7 0.4 1.4 1 1 0 1 1 1 0 zinc-finger of a C2HC-type zf-RING_3 PF14369.1 AIC15640.1 - 0.061 13.3 0.1 0.091 12.7 0.1 1.3 1 0 0 1 1 1 0 zinc-finger Cys_rich_CPXG PF14255.1 AIC15640.1 - 0.093 12.5 0.1 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Cysteine-rich CPXCG ADK_lid PF05191.9 AIC15640.1 - 0.094 12.3 0.1 0.15 11.7 0.1 1.3 1 0 0 1 1 1 0 Adenylate kinase, active site lid zinc_ribbon_2 PF13240.1 AIC15640.1 - 0.096 12.2 0.2 0.14 11.6 0.1 1.3 1 0 0 1 1 1 0 zinc-ribbon domain zf-TRAF PF02176.13 AIC15640.1 - 0.11 12.9 0.2 0.13 12.6 0.1 1.1 1 0 0 1 1 1 0 TRAF-type zinc finger Rad50_zn_hook PF04423.9 AIC15640.1 - 0.11 11.9 0.2 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Rad50 zinc hook motif Prok-RING_1 PF14446.1 AIC15640.1 - 0.12 12.1 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 HD_3 PF13023.1 AIC15641.1 - 3.3e-36 124.5 0.1 4e-36 124.2 0.1 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 AIC15641.1 - 0.0016 18.4 1.6 0.0084 16.1 1.1 2.0 1 1 0 1 1 1 1 HD domain Saccharop_dh_N PF04455.7 AIC15643.1 - 2.5e-37 127.1 0.0 5.7e-37 125.9 0.0 1.6 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Band_7 PF01145.20 AIC15644.1 - 8.3e-32 110.5 7.7 1.2e-31 109.9 5.4 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 AIC15644.1 - 3.6e-05 23.3 0.6 7.7e-05 22.3 0.4 1.5 1 0 0 1 1 1 1 SPFH domain-Band 7 family Tyr_Deacylase PF02580.11 AIC15644.1 - 0.00096 19.1 0.2 0.0034 17.3 0.0 2.0 2 0 0 2 2 2 1 D-Tyr-tRNA(Tyr) deacylase SelR PF01641.13 AIC15645.1 - 5.9e-48 161.6 0.3 7.1e-48 161.3 0.2 1.0 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.9 AIC15645.1 - 0.0025 17.8 0.1 0.005 16.8 0.0 1.5 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TF_Zn_Ribbon PF08271.7 AIC15645.1 - 0.0036 16.5 1.2 0.55 9.5 0.1 2.7 2 0 0 2 2 2 1 TFIIB zinc-binding DZR PF12773.2 AIC15645.1 - 0.0037 17.0 1.7 0.03 14.1 1.2 2.4 1 1 0 1 1 1 1 Double zinc ribbon GFA PF04828.9 AIC15645.1 - 0.01 15.7 2.1 2.2 8.2 0.3 2.2 1 1 1 2 2 2 2 Glutathione-dependent formaldehyde-activating enzyme DUF678 PF05077.7 AIC15645.1 - 0.044 13.7 0.2 0.75 9.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zinc_ribbon_2 PF13240.1 AIC15645.1 - 0.049 13.1 2.4 7 6.2 0.1 2.9 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 AIC15645.1 - 0.052 13.5 0.5 4.6 7.2 0.1 2.4 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2HC5 PF06221.8 AIC15645.1 - 0.11 12.2 1.1 0.41 10.4 0.1 2.1 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type HECT_2 PF09814.4 AIC15645.1 - 0.11 11.1 0.3 0.58 8.8 0.0 1.9 1 1 1 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zf-ribbon_3 PF13248.1 AIC15645.1 - 0.12 11.6 4.6 2.6 7.3 0.1 2.9 2 1 1 3 3 3 0 zinc-ribbon domain DUF2296 PF10058.4 AIC15645.1 - 0.12 12.0 1.9 10 5.9 0.2 2.4 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) Zn_ribbon_recom PF13408.1 AIC15645.1 - 0.13 12.5 1.0 24 5.3 0.3 2.6 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-HIT PF04438.11 AIC15645.1 - 0.65 9.6 5.8 0.4 10.3 0.2 2.6 2 1 0 2 2 2 0 HIT zinc finger Lar_restr_allev PF14354.1 AIC15645.1 - 1.6 9.0 6.6 5.1 7.4 1.4 2.3 1 1 1 2 2 2 0 Restriction alleviation protein Lar Endonuclease_7 PF02945.10 AIC15645.1 - 1.9 8.2 4.8 19 5.0 3.3 2.3 1 1 0 1 1 1 0 Recombination endonuclease VII E6 PF00518.12 AIC15647.1 - 0.04 14.2 0.3 0.041 14.2 0.2 1.0 1 0 0 1 1 1 0 Early Protein (E6) zf-C2HC_2 PF13913.1 AIC15647.1 - 0.075 12.7 2.6 0.089 12.4 0.0 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-PHD-like PF15446.1 AIC15647.1 - 0.096 11.9 0.3 0.1 11.9 0.2 1.1 1 0 0 1 1 1 0 PHD/FYVE-zinc-finger like domain YHS PF04945.8 AIC15648.1 - 3.1e-08 33.3 1.2 3.2e-08 33.2 0.8 1.0 1 0 0 1 1 1 1 YHS domain Arc_trans_TRASH PF08394.5 AIC15648.1 - 0.0033 17.5 0.2 0.0034 17.5 0.2 1.2 1 0 0 1 1 1 1 Archaeal TRASH domain ATPase-cat_bd PF12156.3 AIC15648.1 - 0.031 14.7 0.3 0.033 14.6 0.2 1.1 1 0 0 1 1 1 0 Putative metal-binding domain of cation transport ATPase Zn_Tnp_IS1595 PF12760.2 AIC15648.1 - 0.032 14.0 0.2 0.032 14.0 0.1 1.1 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.1 AIC15648.1 - 0.037 14.3 2.4 0.041 14.1 1.7 1.2 1 0 0 1 1 1 0 Zinc-finger double domain TFIIS_C PF01096.13 AIC15648.1 - 0.075 12.6 0.6 0.081 12.5 0.4 1.1 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) zf-FCS PF06467.9 AIC15648.1 - 0.089 12.4 3.3 0.1 12.2 2.3 1.1 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 PF13894.1 AIC15648.1 - 2.2 8.7 5.6 0.42 11.0 1.7 1.5 2 0 0 2 2 2 0 C2H2-type zinc finger PadR PF03551.9 AIC15649.1 - 1.6e-13 50.2 0.0 3.4e-13 49.1 0.0 1.6 1 1 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_45 PF14947.1 AIC15649.1 - 0.0016 18.1 0.2 0.0038 17.0 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix TrmB PF01978.14 AIC15649.1 - 0.0037 16.9 0.1 0.026 14.2 0.0 2.4 2 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB DUF4423 PF14394.1 AIC15649.1 - 0.048 13.2 0.0 0.076 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) DUF2067 PF09840.4 AIC15649.1 - 0.051 13.0 0.1 0.13 11.8 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) HTH_IclR PF09339.5 AIC15649.1 - 0.062 12.9 0.0 0.17 11.4 0.0 1.8 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF1803 PF08820.5 AIC15649.1 - 0.081 12.6 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) GatB_N PF02934.10 AIC15650.1 - 3e-102 341.4 0.0 4.2e-102 340.9 0.0 1.2 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.13 AIC15650.1 - 3.7e-33 114.3 2.7 6e-33 113.6 1.9 1.3 1 0 0 1 1 1 1 GatB domain Amidase PF01425.16 AIC15651.1 - 4.7e-146 487.0 0.1 5.4e-146 486.9 0.1 1.0 1 0 0 1 1 1 1 Amidase Glu-tRNAGln PF02686.10 AIC15652.1 - 6.3e-07 29.0 0.0 8.1e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit NPR1_like_C PF12313.3 AIC15652.1 - 0.018 14.4 0.3 0.019 14.3 0.2 1.1 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal Methyltransf_1N PF02870.10 AIC15652.1 - 0.085 13.4 0.0 0.14 12.8 0.0 1.4 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain tRNA-synt_2 PF00152.15 AIC15653.1 - 3.3e-86 289.1 0.1 4.8e-86 288.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AIC15653.1 - 9e-14 51.0 0.1 1.9e-13 50.0 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.15 AIC15653.1 - 0.0019 17.4 0.2 0.0064 15.7 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) DsbD PF02683.10 AIC15655.1 - 3.7e-53 180.2 15.9 2e-52 177.8 11.0 2.0 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region AhpC-TSA PF00578.16 AIC15655.1 - 7.5e-24 83.7 0.0 1.2e-23 83.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.5 AIC15655.1 - 2.2e-22 79.1 0.0 3.6e-22 78.5 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.1 AIC15655.1 - 3.7e-14 52.5 0.0 8.3e-13 48.2 0.0 2.5 3 0 0 3 3 3 1 Thioredoxin-like Thioredoxin PF00085.15 AIC15655.1 - 1.6e-05 24.5 0.0 3.3e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 AIC15655.1 - 2.5e-05 24.4 0.0 4.4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like domain GSHPx PF00255.14 AIC15655.1 - 0.00019 20.7 0.0 0.00034 19.9 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase SCO1-SenC PF02630.9 AIC15655.1 - 0.043 13.4 0.0 0.081 12.5 0.0 1.4 1 0 0 1 1 1 0 SCO1/SenC DUF1625 PF07787.7 AIC15655.1 - 0.34 10.1 7.8 0.47 9.6 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1625) DUF2207 PF09972.4 AIC15655.1 - 1.2 7.6 8.9 0.091 11.3 0.7 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) BNR_2 PF13088.1 AIC15656.1 - 1.2e-12 47.7 0.7 6.6e-09 35.4 0.0 2.5 1 1 1 2 2 2 2 BNR repeat-like domain BNR PF02012.15 AIC15656.1 - 2.3e-06 26.5 8.4 0.47 10.4 0.1 5.5 5 0 0 5 5 5 3 BNR/Asp-box repeat PSII_BNR PF14870.1 AIC15656.1 - 0.027 13.4 0.3 2.8 6.8 0.0 3.0 3 0 0 3 3 3 0 Photosynthesis system II assembly factor YCF48 PQQ_3 PF13570.1 AIC15656.1 - 0.04 14.2 1.4 0.55 10.5 0.1 3.3 3 0 0 3 3 3 0 PQQ-like domain DHHA1 PF02272.14 AIC15659.1 - 0.012 15.2 3.9 0.031 13.9 2.3 2.0 2 0 0 2 2 2 0 DHHA1 domain tRNA_SAD PF07973.9 AIC15659.1 - 0.03 14.2 0.2 0.067 13.0 0.1 1.7 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain HTH_20 PF12840.2 AIC15660.1 - 1.2e-06 28.1 1.8 2.6e-06 27.1 0.2 2.3 3 0 0 3 3 3 1 Helix-turn-helix domain MarR_2 PF12802.2 AIC15660.1 - 2.7e-05 23.7 1.1 4.8e-05 22.9 0.1 1.9 2 0 0 2 2 2 1 MarR family DUF1724 PF08350.5 AIC15660.1 - 0.0026 17.2 0.0 0.0046 16.4 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1724) HTH_5 PF01022.15 AIC15660.1 - 0.022 14.4 0.2 0.075 12.7 0.0 1.9 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.1 AIC15660.1 - 0.063 13.0 0.4 0.43 10.3 0.0 2.4 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain HTH_24 PF13412.1 AIC15660.1 - 0.091 12.1 0.2 0.19 11.1 0.0 1.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding CarboxypepD_reg PF13620.1 AIC15661.1 - 6.1e-10 39.0 0.0 1.6e-09 37.7 0.0 1.8 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain DUF4480 PF13715.1 AIC15661.1 - 0.065 13.2 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4480) HlyIII PF03006.15 AIC15662.1 - 0.065 12.6 4.4 0.084 12.2 3.0 1.2 1 0 0 1 1 1 0 Haemolysin-III related 7TM-7TMR_HD PF07698.6 AIC15662.1 - 0.066 12.6 5.2 0.086 12.2 3.6 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase PTPS_related PF10131.4 AIC15662.1 - 0.71 7.9 4.9 0.38 8.8 1.3 1.8 2 0 0 2 2 2 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF202 PF02656.10 AIC15662.1 - 2.5 8.3 10.1 2e+02 2.2 7.0 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF1297 PF06973.7 AIC15663.1 - 2.9e-73 245.2 0.0 3.7e-73 244.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.7 AIC15663.1 - 1.4e-30 105.6 0.0 2e-30 105.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) ATP-grasp_4 PF13535.1 AIC15663.1 - 0.0016 18.1 0.0 0.041 13.6 0.0 2.2 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.12 AIC15663.1 - 0.015 14.5 0.0 0.025 13.8 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Ehbp PF10622.4 AIC15663.1 - 0.13 12.2 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Energy-converting hydrogenase B subunit P (EhbP) YtkA PF13115.1 AIC15664.1 - 0.009 16.3 0.2 0.18 12.1 0.1 2.5 2 0 0 2 2 2 1 YtkA-like DUF1129 PF06570.6 AIC15664.1 - 0.39 10.0 3.6 0.58 9.4 2.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) CelD_N PF02927.9 AIC15666.1 - 0.1 12.8 0.1 0.49 10.6 0.1 1.9 1 1 1 2 2 2 0 N-terminal ig-like domain of cellulase TrbC PF04956.8 AIC15667.1 - 0.25 11.3 3.2 0.5 10.3 0.2 2.1 2 0 0 2 2 2 0 TrbC/VIRB2 family HTH_5 PF01022.15 AIC15668.1 - 2.9e-14 52.4 0.1 1.2e-10 40.8 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 AIC15668.1 - 1.9e-12 46.3 0.1 6.5e-06 25.4 0.0 2.3 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC15668.1 - 1.2e-10 40.9 0.4 2.7e-06 26.9 0.0 2.2 2 0 0 2 2 2 2 MarR family HTH_20 PF12840.2 AIC15668.1 - 7.5e-10 38.4 0.3 0.00013 21.6 0.0 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_IclR PF09339.5 AIC15668.1 - 4e-06 26.3 0.7 0.0026 17.3 0.0 2.4 2 1 0 2 2 2 2 IclR helix-turn-helix domain HTH_34 PF13601.1 AIC15668.1 - 5.6e-06 26.2 0.0 0.031 14.3 0.0 2.2 2 0 0 2 2 2 2 Winged helix DNA-binding domain MarR PF01047.17 AIC15668.1 - 5.9e-06 25.8 0.1 0.12 12.0 0.0 2.2 2 0 0 2 2 2 2 MarR family TrmB PF01978.14 AIC15668.1 - 2.1e-05 24.1 0.1 0.0016 18.1 0.0 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB LexA_DNA_bind PF01726.11 AIC15668.1 - 0.00015 21.2 0.2 0.14 11.6 0.0 2.7 2 1 0 2 2 2 2 LexA DNA binding domain Rrf2 PF02082.15 AIC15668.1 - 0.00032 20.7 0.1 0.03 14.4 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator Sulfolobus_pRN PF05584.6 AIC15668.1 - 0.00038 20.3 0.1 0.0069 16.3 0.0 2.5 2 1 1 3 3 3 1 Sulfolobus plasmid regulatory protein HTH_38 PF13936.1 AIC15668.1 - 0.0004 19.8 0.0 0.0011 18.5 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Crp_2 PF13545.1 AIC15668.1 - 0.00078 19.1 0.1 0.022 14.5 0.0 2.6 2 2 0 2 2 2 1 Crp-like helix-turn-helix domain Penicillinase_R PF03965.11 AIC15668.1 - 0.0074 16.3 0.1 0.065 13.3 0.0 2.4 2 2 1 3 3 3 1 Penicillinase repressor DUF2513 PF10711.4 AIC15668.1 - 0.027 14.5 0.0 1.4 9.0 0.0 2.6 2 1 0 2 2 2 0 Hypothetical protein (DUF2513) HTH_29 PF13551.1 AIC15668.1 - 0.045 13.9 0.1 2.3 8.3 0.0 2.2 1 1 1 2 2 2 0 Winged helix-turn helix RepL PF05732.6 AIC15668.1 - 0.047 12.9 0.0 0.1 11.8 0.0 1.5 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) Fe_dep_repress PF01325.14 AIC15668.1 - 0.052 13.5 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_36 PF13730.1 AIC15668.1 - 0.052 13.6 0.0 0.18 11.9 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_DeoR PF08220.7 AIC15668.1 - 0.06 12.8 0.0 0.14 11.6 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_40 PF14493.1 AIC15668.1 - 0.084 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2177 PF09945.4 AIC15669.1 - 0.12 12.3 2.7 0.17 11.9 1.5 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2177) 7TMR-DISM_7TM PF07695.6 AIC15669.1 - 0.14 11.7 14.6 0.23 11.1 10.1 1.4 1 1 0 1 1 1 0 7TM diverse intracellular signalling Arteri_Gl PF00951.13 AIC15669.1 - 0.16 11.5 4.0 0.23 11.0 2.7 1.4 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein DUF3816 PF12822.2 AIC15669.1 - 8.9 6.1 15.1 6.3 6.6 2.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3816) CopD PF05425.8 AIC15670.1 - 3.6e-18 65.7 9.3 3.6e-18 65.7 6.5 4.4 5 1 0 5 5 5 1 Copper resistance protein D CopC PF04234.7 AIC15670.1 - 2.9e-13 50.2 0.0 5.8e-13 49.2 0.0 1.6 1 0 0 1 1 1 1 CopC domain YtkA PF13115.1 AIC15670.1 - 0.0022 18.2 0.8 0.0086 16.4 0.0 2.2 2 0 0 2 2 2 1 YtkA-like CopC PF04234.7 AIC15672.1 - 3e-18 66.2 0.0 8.2e-18 64.8 0.0 1.8 1 0 0 1 1 1 1 CopC domain SGL PF08450.7 AIC15672.1 - 1.3e-13 50.9 0.0 0.00051 19.5 0.0 4.2 2 1 1 3 3 3 3 SMP-30/Gluconolaconase/LRE-like region CopD PF05425.8 AIC15672.1 - 3e-10 40.2 6.1 3e-10 40.2 4.2 3.7 3 1 1 4 4 4 1 Copper resistance protein D Reg_prop PF07494.6 AIC15672.1 - 7.4e-07 28.4 11.0 3.1 8.1 0.0 7.7 9 0 0 9 9 9 2 Two component regulator propeller DUF4149 PF13664.1 AIC15672.1 - 8.1e-06 25.8 3.8 8.1e-06 25.8 2.7 3.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) YtkA PF13115.1 AIC15672.1 - 0.00033 20.9 0.0 0.00089 19.5 0.0 1.8 1 0 0 1 1 1 1 YtkA-like SBBP PF06739.6 AIC15672.1 - 0.011 15.5 0.5 7.8 6.3 0.0 4.1 4 0 0 4 4 4 0 Beta-propeller repeat NHL PF01436.16 AIC15672.1 - 0.012 15.5 1.0 1.1e+02 2.9 0.0 5.3 5 0 0 5 5 5 0 NHL repeat DUF3272 PF11676.3 AIC15673.1 - 0.015 15.3 4.4 0.015 15.3 3.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3272) DUF3043 PF11241.3 AIC15673.1 - 1.2 8.7 3.8 0.33 10.5 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3043) UCR_UQCRX_QCR9 PF05365.7 AIC15673.1 - 1.2 8.8 4.8 15 5.2 1.4 2.6 2 0 0 2 2 2 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like PepSY_TM_2 PF13703.1 AIC15673.1 - 2.4 8.3 13.0 6.4e+02 0.6 9.0 3.0 1 1 0 1 1 1 0 PepSY-associated TM helix HXXEE PF13787.1 AIC15673.1 - 5.4 7.4 15.6 11 6.3 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function with HXXEE motif DUF1469 PF07332.6 AIC15673.1 - 6.8 6.4 11.9 6.3 6.5 3.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1469) DUF3395 PF11875.3 AIC15674.1 - 0.015 14.9 1.2 0.025 14.2 0.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3395) FlaC_arch PF05377.6 AIC15674.1 - 0.069 13.0 3.5 0.69 9.8 0.7 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2443 PF10398.4 AIC15674.1 - 0.098 12.4 2.6 0.14 11.9 0.5 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2443) Bap31 PF05529.7 AIC15674.1 - 0.11 11.8 2.9 0.14 11.6 2.0 1.1 1 0 0 1 1 1 0 B-cell receptor-associated protein 31-like ZapA PF05164.8 AIC15674.1 - 0.12 12.3 3.6 0.16 11.9 2.5 1.3 1 1 0 1 1 1 0 Cell division protein ZapA DUF2721 PF11026.3 AIC15674.1 - 0.13 11.8 2.0 0.13 11.9 1.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) Atg14 PF10186.4 AIC15674.1 - 0.32 9.8 2.6 0.34 9.7 1.8 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Tropomyosin_1 PF12718.2 AIC15674.1 - 0.48 10.2 6.6 1.4 8.7 4.6 1.7 1 1 0 1 1 1 0 Tropomyosin like DMPK_coil PF08826.5 AIC15674.1 - 0.63 9.9 5.6 0.23 11.3 1.2 2.0 1 1 1 2 2 2 0 DMPK coiled coil domain like DUF4200 PF13863.1 AIC15674.1 - 0.64 9.9 7.6 0.2 11.6 1.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) PhoU PF01895.14 AIC15674.1 - 0.97 9.9 4.9 0.27 11.7 1.3 1.6 2 0 0 2 2 2 0 PhoU domain TMF_DNA_bd PF12329.3 AIC15674.1 - 1 9.2 7.7 0.42 10.4 1.4 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.10 AIC15674.1 - 1.3 8.5 5.6 0.21 11.0 0.7 1.8 2 0 0 2 2 2 0 Septum formation initiator Prefoldin PF02996.12 AIC15674.1 - 1.8 8.1 6.5 0.6 9.7 1.6 2.0 1 1 1 2 2 2 0 Prefoldin subunit AAA_23 PF13476.1 AIC15674.1 - 2 8.6 4.9 2.2 8.5 3.4 1.1 1 0 0 1 1 1 0 AAA domain WEMBL PF05701.6 AIC15675.1 - 0.019 13.4 1.0 0.026 13.0 0.7 1.1 1 0 0 1 1 1 0 Weak chloroplast movement under blue light FliJ PF02050.11 AIC15675.1 - 0.025 14.6 0.1 0.04 13.9 0.1 1.2 1 0 0 1 1 1 0 Flagellar FliJ protein YtkA PF13115.1 AIC15675.1 - 0.031 14.6 0.0 0.058 13.7 0.0 1.5 1 0 0 1 1 1 0 YtkA-like OspD PF03207.8 AIC15675.1 - 0.035 13.2 1.1 0.051 12.7 0.8 1.2 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) phage_tail_N PF08400.5 AIC15675.1 - 0.06 13.0 1.7 0.12 12.0 1.2 1.6 1 1 0 1 1 1 0 Prophage tail fibre N-terminal DUF948 PF06103.6 AIC15675.1 - 0.42 10.5 0.1 0.42 10.5 0.1 2.4 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) PPC PF04151.10 AIC15676.1 - 0.00096 20.0 0.1 0.0018 19.1 0.1 1.4 1 0 0 1 1 1 1 Bacterial pre-peptidase C-terminal domain Filamin PF00630.14 AIC15676.1 - 0.0073 16.8 0.0 0.011 16.2 0.0 1.4 1 1 0 1 1 1 1 Filamin/ABP280 repeat Big_3_4 PF13754.1 AIC15676.1 - 0.033 14.5 0.1 1.2 9.5 0.0 2.5 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) ETRAMP PF09716.5 AIC15677.1 - 0.073 13.0 0.6 3.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Cupredoxin_1 PF13473.1 AIC15678.1 - 5.4e-10 39.0 1.7 2.7e-07 30.4 0.0 3.1 2 2 0 2 2 2 2 Cupredoxin-like domain Copper-bind PF00127.15 AIC15678.1 - 2.2e-08 34.2 0.5 3.3e-06 27.2 0.0 2.5 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Peripla_BP_2 PF01497.13 AIC15679.1 - 7.8e-39 133.2 0.0 9.5e-39 132.9 0.0 1.1 1 0 0 1 1 1 1 Periplasmic binding protein Ribosomal_S10 PF00338.17 AIC15680.1 - 2.3e-26 91.4 0.0 2.6e-26 91.3 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e GTP_EFTU PF00009.22 AIC15681.1 - 4.2e-51 173.0 0.0 9e-51 171.9 0.0 1.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.12 AIC15681.1 - 3.3e-30 104.1 0.0 1.5e-29 102.0 0.1 2.2 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.20 AIC15681.1 - 7.3e-17 61.2 5.5 9e-17 60.9 1.3 2.7 3 0 0 3 3 3 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.1 AIC15681.1 - 1.7e-06 27.5 1.5 3.9e-06 26.3 1.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.18 AIC15681.1 - 0.00028 20.8 0.0 0.00068 19.5 0.0 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 AIC15681.1 - 0.0017 18.8 0.2 0.0099 16.3 0.1 2.2 1 1 0 1 1 1 1 Miro-like protein YajC PF02699.10 AIC15681.1 - 0.052 13.2 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit Gtr1_RagA PF04670.7 AIC15681.1 - 0.095 11.8 0.0 0.41 9.7 0.0 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region DUF2228 PF10228.4 AIC15681.1 - 0.12 11.8 0.0 0.23 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) FBPase_3 PF01950.11 AIC15682.1 - 7.4e-151 502.2 0.1 8.4e-151 502.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-1,6-bisphosphatase YopR_core PF09025.5 AIC15682.1 - 0.16 11.9 0.0 15 5.5 0.0 2.2 1 1 1 2 2 2 0 YopR Core TIM PF00121.13 AIC15683.1 - 3.6e-25 88.4 0.8 2.1e-16 59.7 0.0 2.0 1 1 1 2 2 2 2 Triosephosphate isomerase IGPS PF00218.16 AIC15683.1 - 7.7e-05 21.8 0.0 0.00026 20.1 0.0 1.7 1 1 0 2 2 2 1 Indole-3-glycerol phosphate synthase ThiG PF05690.9 AIC15683.1 - 0.00029 20.0 0.4 0.00029 20.0 0.3 2.1 2 1 1 3 3 3 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 AIC15683.1 - 0.045 13.0 0.2 0.098 11.9 0.1 1.5 1 0 0 1 1 1 0 Histidine biosynthesis protein FMN_dh PF01070.13 AIC15683.1 - 0.11 11.3 0.7 0.19 10.5 0.2 1.6 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Methyltransf_31 PF13847.1 AIC15684.1 - 2.5e-18 66.1 0.0 4.5e-18 65.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15684.1 - 3.3e-16 59.8 0.3 2.9e-15 56.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC15684.1 - 5.9e-13 49.1 0.0 1.4e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15684.1 - 2.8e-11 43.7 0.2 3.6e-10 40.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15684.1 - 4.3e-11 42.7 0.0 3.4e-10 39.8 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15684.1 - 4.7e-09 36.5 0.0 9e-09 35.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC15684.1 - 2e-07 31.0 0.1 8e-07 29.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain GCD14 PF08704.5 AIC15684.1 - 2.1e-07 30.6 0.0 3.2e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit MTS PF05175.9 AIC15684.1 - 3e-07 29.9 0.2 1.5e-06 27.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_4 PF02390.12 AIC15684.1 - 1.7e-05 23.9 0.0 3.5e-05 22.9 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase Ubie_methyltran PF01209.13 AIC15684.1 - 3.7e-05 22.9 0.0 5.9e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PrmA PF06325.8 AIC15684.1 - 4.3e-05 22.7 0.0 9e-05 21.7 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.15 AIC15684.1 - 6.5e-05 22.1 0.0 0.00013 21.1 0.0 1.5 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.13 AIC15684.1 - 0.00027 20.1 0.3 0.011 14.9 0.0 2.3 2 0 0 2 2 2 1 O-methyltransferase Methyltransf_24 PF13578.1 AIC15684.1 - 0.00035 21.3 0.0 0.00096 19.9 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain UPF0020 PF01170.13 AIC15684.1 - 0.001 18.6 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 PCMT PF01135.14 AIC15684.1 - 0.0096 15.4 0.0 0.017 14.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FmrO PF07091.6 AIC15684.1 - 0.015 14.3 0.0 0.024 13.6 0.0 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) TehB PF03848.9 AIC15684.1 - 0.02 14.0 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_15 PF09445.5 AIC15684.1 - 0.03 13.8 0.0 0.042 13.3 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase UPF0126 PF03458.8 AIC15685.1 - 3.4e-43 145.1 30.6 4.3e-24 83.9 5.2 2.3 3 0 0 3 3 3 2 UPF0126 domain B12D PF06522.6 AIC15685.1 - 0.19 11.4 0.2 0.19 11.4 0.2 2.7 3 0 0 3 3 3 0 NADH-ubiquinone reductase complex 1 MLRQ subunit PRA1 PF03208.14 AIC15685.1 - 7.7 5.8 8.7 29 3.9 6.0 2.0 1 1 0 1 1 1 0 PRA1 family protein PEP-utilizers_C PF02896.13 AIC15686.1 - 1.7e-90 302.8 2.7 2.4e-90 302.3 1.9 1.2 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.14 AIC15686.1 - 7.1e-63 212.6 0.0 2e-62 211.1 0.0 1.7 1 1 0 1 1 1 1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.18 AIC15686.1 - 1.7e-23 81.9 0.4 5.8e-23 80.2 0.3 1.9 1 0 0 1 1 1 1 PEP-utilising enzyme, mobile domain HpcH_HpaI PF03328.9 AIC15686.1 - 0.0062 15.4 0.1 0.013 14.4 0.0 1.5 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family Polysacc_synt_3 PF13440.1 AIC15687.1 - 0.31 10.4 2.2 0.76 9.1 0.2 1.9 2 0 0 2 2 2 0 Polysaccharide biosynthesis protein MFS_1 PF07690.11 AIC15688.1 - 5.8e-43 146.9 52.8 4.3e-42 144.1 34.5 2.5 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.19 AIC15688.1 - 6.4e-10 38.1 14.6 6.4e-10 38.1 10.1 2.4 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.1 AIC15688.1 - 5.7e-05 21.6 8.6 5.7e-05 21.6 5.9 4.1 1 1 1 2 2 2 1 MFS/sugar transport protein Glyoxalase_2 PF12681.2 AIC15689.1 - 5.1e-12 46.3 0.0 7.1e-12 45.9 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 AIC15689.1 - 3.7e-06 26.9 0.0 8.6e-06 25.7 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Topoisom_I_N PF02919.10 AIC15689.1 - 0.033 13.4 0.2 0.7 9.1 0.1 2.0 1 1 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment HlyU PF10115.4 AIC15689.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Transcriptional activator HlyU DUF1428 PF07237.6 AIC15690.1 - 5e-08 32.7 0.1 6.6e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1428) HTH_45 PF14947.1 AIC15691.1 - 1.3e-13 50.5 0.1 1.9e-13 50.0 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DUF1611 PF07755.6 AIC15691.1 - 0.13 10.9 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1611) Rio2_N PF09202.6 AIC15691.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Rio2, N-terminal MEDS PF14417.1 AIC15692.1 - 1.5e-10 40.4 0.0 1.9e-10 40.1 0.0 1.2 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain KaiC PF06745.8 AIC15692.1 - 0.00019 20.6 0.0 0.00023 20.3 0.0 1.2 1 0 0 1 1 1 1 KaiC DNA_RNApol_7kD PF03604.8 AIC15693.1 - 4.1e-06 26.1 2.4 6.8e-06 25.4 1.7 1.4 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf-Mss51 PF13824.1 AIC15693.1 - 0.097 12.5 0.1 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-C2H2 PF00096.21 AIC15694.1 - 1.5e-07 31.3 6.6 0.00069 19.8 1.0 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AIC15694.1 - 3.5e-07 30.1 2.2 0.0019 18.4 0.5 2.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.1 AIC15694.1 - 6.2e-05 22.7 7.5 0.00014 21.6 1.2 2.4 2 1 0 2 2 2 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AIC15694.1 - 0.00015 21.8 8.1 0.031 14.5 0.3 2.8 3 0 0 3 3 3 2 Zinc-finger double domain Zn-ribbon_8 PF09723.5 AIC15694.1 - 0.0017 18.2 4.2 0.42 10.6 0.2 2.3 2 0 0 2 2 2 2 Zinc ribbon domain zf-C2H2_jaz PF12171.3 AIC15694.1 - 0.002 18.2 6.7 0.2 11.8 0.1 2.3 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding SAE2 PF08573.5 AIC15694.1 - 0.0096 16.6 5.9 0.56 10.9 0.6 2.0 1 1 1 2 2 2 2 DNA repair protein endonuclease SAE2/CtIP C-terminus DUF1610 PF07754.6 AIC15694.1 - 0.011 15.8 1.4 3.4 7.8 0.0 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF1610) DZR PF12773.2 AIC15694.1 - 0.029 14.1 0.8 0.046 13.5 0.6 1.3 1 0 0 1 1 1 0 Double zinc ribbon zf-Di19 PF05605.7 AIC15694.1 - 0.038 14.1 3.0 0.051 13.7 2.1 1.3 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.2 AIC15694.1 - 0.04 14.0 8.6 0.75 9.9 1.3 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) PolC_DP2 PF03833.8 AIC15694.1 - 0.059 11.0 0.6 0.065 10.8 0.4 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 FYVE PF01363.16 AIC15694.1 - 0.089 12.6 5.0 0.4 10.6 3.2 1.9 1 1 1 2 2 2 0 FYVE zinc finger Prok-RING_1 PF14446.1 AIC15694.1 - 0.1 12.3 2.8 1.2 8.9 0.2 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zf-C2HC_2 PF13913.1 AIC15694.1 - 0.11 12.1 0.6 0.11 12.1 0.4 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type C1_4 PF07975.7 AIC15694.1 - 0.21 11.5 5.9 1.5 8.9 4.2 2.0 1 1 1 2 2 2 0 TFIIH C1-like domain XPA_N PF01286.13 AIC15694.1 - 0.21 11.2 6.6 0.53 10.0 0.5 2.3 2 0 0 2 2 2 0 XPA protein N-terminal zf-CW PF07496.10 AIC15694.1 - 0.22 11.2 1.8 0.39 10.4 1.2 1.5 1 1 0 1 1 1 0 CW-type Zinc Finger zinc-ribbons_6 PF07191.7 AIC15694.1 - 0.35 10.6 4.7 2.5 7.9 0.4 2.1 1 1 1 2 2 2 0 zinc-ribbons Evr1_Alr PF04777.8 AIC15694.1 - 0.36 10.7 4.0 2.6 8.0 0.4 2.1 1 1 1 2 2 2 0 Erv1 / Alr family zf-DBF PF07535.7 AIC15694.1 - 0.44 10.2 6.5 3.9 7.2 0.8 2.4 1 1 1 2 2 2 0 DBF zinc finger TFIIS_C PF01096.13 AIC15694.1 - 0.65 9.6 4.6 1.8 8.2 0.1 2.5 2 1 0 2 2 2 0 Transcription factor S-II (TFIIS) DUF629 PF04780.7 AIC15694.1 - 0.78 8.1 6.3 0.61 8.5 0.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF629) PHD PF00628.24 AIC15694.1 - 1.2 8.8 5.4 4.5 7.0 3.9 1.8 1 1 0 1 1 1 0 PHD-finger zf-IS66 PF13005.2 AIC15694.1 - 1.7 8.6 4.9 20 5.2 3.4 2.1 1 1 0 1 1 1 0 zinc-finger binding domain of transposase IS66 C1_1 PF00130.17 AIC15695.1 - 0.00061 19.4 12.4 0.11 12.2 0.5 3.4 2 1 1 3 3 3 2 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF4428 PF14471.1 AIC15695.1 - 0.017 14.8 12.6 0.12 12.1 0.4 4.0 3 2 0 3 3 3 0 Domain of unknown function (DUF4428) Chordopox_RPO7 PF05864.7 AIC15695.1 - 0.063 13.3 0.1 17 5.5 0.0 2.8 2 0 0 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) zf-dskA_traR PF01258.12 AIC15695.1 - 0.082 12.6 12.0 4.5 7.1 0.1 4.8 5 0 0 5 5 5 0 Prokaryotic dksA/traR C4-type zinc finger LIM PF00412.17 AIC15695.1 - 0.091 12.8 10.7 3.4 7.8 0.8 3.9 3 3 0 3 3 3 0 LIM domain zf-C4pol PF14260.1 AIC15695.1 - 0.11 12.5 11.2 0.079 12.9 1.5 3.2 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta zinc_ribbon_2 PF13240.1 AIC15695.1 - 0.3 10.6 0.2 0.3 10.6 0.1 3.8 5 0 0 5 5 3 0 zinc-ribbon domain Cytochrom_c3_2 PF14537.1 AIC15695.1 - 0.33 11.3 9.2 0.047 14.0 1.7 2.6 2 1 1 3 3 3 0 Cytochrome c3 zf-ribbon_3 PF13248.1 AIC15695.1 - 0.33 10.2 4.9 0.74 9.0 0.1 3.4 4 0 0 4 4 4 0 zinc-ribbon domain DZR PF12773.2 AIC15695.1 - 0.33 10.7 20.9 2.2 8.1 4.0 3.8 1 1 1 2 2 2 0 Double zinc ribbon FYVE PF01363.16 AIC15695.1 - 0.77 9.6 16.2 2.4e+03 -1.5 11.3 3.0 1 1 0 1 1 1 0 FYVE zinc finger RRN7 PF11781.3 AIC15695.1 - 1.9 8.0 8.2 15 5.1 0.0 4.0 4 0 0 4 4 4 0 RNA polymerase I-specific transcription initiation factor Rrn7 Zn_ribbon_recom PF13408.1 AIC15695.1 - 2.3 8.5 12.6 9.2 6.6 1.1 2.7 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain Cytochrome_C7 PF14522.1 AIC15695.1 - 3.2 7.4 12.1 15 5.3 3.6 3.0 1 1 1 2 2 2 0 Cytochrome c7 Nudix_N_2 PF14803.1 AIC15695.1 - 4.1 7.1 11.0 6 6.6 0.1 3.5 3 1 0 3 3 3 0 Nudix N-terminal Ribosomal_S14 PF00253.16 AIC15695.1 - 6.1 6.3 6.5 6.2 6.2 1.0 3.1 3 1 0 3 3 3 0 Ribosomal protein S14p/S29e P-II PF00543.17 AIC15696.1 - 3.7e-17 62.6 0.3 4.2e-17 62.4 0.2 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II RHH_1 PF01402.16 AIC15697.1 - 0.0024 17.7 0.0 0.003 17.4 0.0 1.1 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family DPCD PF14913.1 AIC15697.1 - 0.08 12.0 0.0 0.08 12.0 0.0 1.0 1 0 0 1 1 1 0 DPCD protein family P-II PF00543.17 AIC15698.1 - 3.5e-19 69.1 0.1 3.9e-19 69.0 0.1 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II adh_short_C2 PF13561.1 AIC15700.1 - 1.7e-36 126.2 0.2 1.9e-36 126.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.20 AIC15700.1 - 8.8e-33 113.5 0.3 1.2e-32 113.1 0.2 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.5 AIC15700.1 - 3.4e-11 43.1 0.1 5e-11 42.6 0.1 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 AIC15700.1 - 1.8e-08 34.6 0.2 2.8e-08 34.0 0.2 1.3 1 0 0 1 1 1 1 NADH(P)-binding Epimerase PF01370.16 AIC15700.1 - 2e-08 33.9 0.4 6.3e-08 32.3 0.3 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Shikimate_DH PF01488.15 AIC15700.1 - 2.9e-06 27.4 1.3 5.9e-06 26.4 0.9 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Polysacc_synt_2 PF02719.10 AIC15700.1 - 3e-06 26.3 0.7 4.2e-06 25.8 0.5 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Saccharop_dh PF03435.13 AIC15700.1 - 1.3e-05 24.4 0.5 1.8e-05 23.9 0.3 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase F420_oxidored PF03807.12 AIC15700.1 - 0.00011 22.5 1.4 0.00021 21.6 1.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent 3Beta_HSD PF01073.14 AIC15700.1 - 0.00014 20.7 0.2 0.00017 20.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.7 AIC15700.1 - 0.00025 20.0 0.2 0.00043 19.2 0.1 1.4 1 0 0 1 1 1 1 Male sterility protein 3HCDH_N PF02737.13 AIC15700.1 - 0.00061 19.4 1.1 0.00089 18.9 0.8 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 AIC15700.1 - 0.00068 19.6 0.6 0.0012 18.7 0.4 1.4 1 0 0 1 1 1 1 TrkA-N domain NmrA PF05368.8 AIC15700.1 - 0.0022 17.3 0.9 0.014 14.7 0.5 2.0 2 0 0 2 2 2 1 NmrA-like family ApbA PF02558.11 AIC15700.1 - 0.0053 16.2 0.1 0.0084 15.5 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA RmlD_sub_bind PF04321.12 AIC15700.1 - 0.012 14.5 0.3 0.054 12.3 0.1 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain DUF3842 PF12953.2 AIC15700.1 - 0.017 15.2 3.4 0.081 13.0 1.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3842) NAD_binding_2 PF03446.10 AIC15700.1 - 0.026 14.3 0.1 0.045 13.6 0.1 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase CoA_binding_2 PF13380.1 AIC15700.1 - 0.033 14.3 0.0 0.085 13.0 0.0 1.7 1 0 0 1 1 1 0 CoA binding domain 2-Hacid_dh_C PF02826.14 AIC15700.1 - 0.041 13.0 0.2 0.069 12.3 0.2 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF4154 PF13689.1 AIC15700.1 - 0.073 12.6 0.0 0.65 9.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4154) NAD_binding_3 PF03447.11 AIC15700.1 - 0.08 13.3 0.3 0.15 12.4 0.2 1.4 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain DHHA1 PF02272.14 AIC15701.1 - 5.8e-05 22.7 0.1 0.00014 21.5 0.0 1.6 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.15 AIC15701.1 - 0.00037 20.1 0.0 0.00061 19.4 0.0 1.4 1 0 0 1 1 1 1 DHH family HAD_2 PF13419.1 AIC15702.1 - 2.5e-25 89.7 0.0 3.1e-25 89.4 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AIC15702.1 - 2.8e-07 30.1 0.0 1.3e-06 27.9 0.0 2.0 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase PF00702.21 AIC15702.1 - 4.3e-07 30.5 0.1 4.8e-06 27.1 0.1 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AIC15702.1 - 0.00088 19.4 0.0 0.0012 19.0 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase NT5C PF06941.7 AIC15702.1 - 0.0047 16.4 0.0 0.0086 15.5 0.0 1.4 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) Hydrolase_6 PF13344.1 AIC15702.1 - 0.055 13.3 0.1 2.4 8.0 0.0 2.9 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase tRNA-synt_1f PF01921.13 AIC15704.1 - 1.2e-105 353.1 0.0 1.6e-105 352.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (K) tRNA-synt_1g PF09334.6 AIC15704.1 - 0.064 11.9 0.3 0.44 9.1 0.0 2.3 2 1 1 3 3 3 0 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 AIC15704.1 - 0.076 11.0 0.0 0.12 10.3 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Trigger_C PF05698.9 AIC15704.1 - 0.079 12.8 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) C-terminus Radical_SAM PF04055.16 AIC15705.1 - 3.8e-20 72.7 0.0 1e-19 71.2 0.0 1.7 2 0 0 2 2 2 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 AIC15705.1 - 1.4e-10 41.0 0.2 6.6e-10 38.8 0.2 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AIC15705.1 - 0.039 14.1 0.2 0.47 10.6 0.1 2.7 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain AIRS_C PF02769.17 AIC15706.1 - 2.3e-18 66.6 0.0 4.6e-18 65.6 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.19 AIC15706.1 - 2.7e-17 62.7 0.4 6.6e-17 61.5 0.3 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain zf-C2H2_jaz PF12171.3 AIC15708.1 - 0.034 14.2 0.4 0.059 13.5 0.3 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-CGNR PF11706.3 AIC15708.1 - 0.11 12.0 4.4 0.12 11.8 2.2 1.7 2 0 0 2 2 2 0 CGNR zinc finger UreD PF01774.12 AIC15709.1 - 1.3e-48 165.2 0.0 1.6e-48 165.0 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein cobW PF02492.14 AIC15710.1 - 1.5e-34 119.0 0.0 1.7e-34 118.8 0.0 1.0 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain ArgK PF03308.11 AIC15710.1 - 1e-08 34.2 1.1 2.7e-08 32.9 0.8 1.6 1 1 0 1 1 1 1 ArgK protein MobB PF03205.9 AIC15710.1 - 7.2e-06 25.7 0.2 1.6e-05 24.6 0.0 1.8 2 1 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.10 AIC15710.1 - 0.0041 16.8 0.0 0.0082 15.8 0.0 1.5 1 0 0 1 1 1 1 NTPase ABC_tran PF00005.22 AIC15710.1 - 0.012 15.8 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 ABC transporter GTP_EFTU PF00009.22 AIC15710.1 - 0.013 14.9 0.0 6.9 6.0 0.0 2.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain Mg_chelatase PF01078.16 AIC15710.1 - 0.027 13.6 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.1 AIC15710.1 - 0.064 13.0 0.2 0.47 10.2 0.2 2.2 2 1 0 2 2 2 0 Part of AAA domain NACHT PF05729.7 AIC15710.1 - 0.091 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain LpxK PF02606.9 AIC15710.1 - 0.11 11.4 0.0 0.15 11.0 0.0 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase AAA_10 PF12846.2 AIC15710.1 - 0.12 11.8 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_33 PF13671.1 AIC15710.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain UreF PF01730.11 AIC15711.1 - 4.8e-28 98.1 0.0 6.2e-28 97.7 0.0 1.1 1 0 0 1 1 1 1 UreF UreE_N PF02814.10 AIC15712.1 - 8.5e-10 38.0 0.0 1.4e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 UreE urease accessory protein, N-terminal domain UreE_C PF05194.7 AIC15712.1 - 2.5e-07 30.6 0.2 4.6e-07 29.8 0.1 1.4 1 0 0 1 1 1 1 UreE urease accessory protein, C-terminal domain MCR_gamma PF02240.11 AIC15713.1 - 0.09 11.8 0.0 0.11 11.5 0.0 1.2 1 0 0 1 1 1 0 Methyl-coenzyme M reductase gamma subunit Cpn60_TCP1 PF00118.19 AIC15714.1 - 3.3e-106 355.8 5.8 4.1e-106 355.4 4.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Amidohydro_1 PF01979.15 AIC15715.1 - 9.5e-54 183.2 5.4 1.3e-53 182.8 3.7 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.15 AIC15715.1 - 3.5e-50 169.1 1.0 8.9e-50 167.8 0.7 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.6 AIC15715.1 - 3.2e-05 23.3 1.1 3.2e-05 23.3 0.8 2.2 2 0 0 2 2 2 1 Amidohydrolase family Amidohydro_5 PF13594.1 AIC15715.1 - 8.3e-05 22.3 1.0 0.00042 20.0 0.7 2.3 2 0 0 2 2 2 1 Amidohydrolase Urease_beta PF00699.15 AIC15716.1 - 1.1e-41 140.6 0.0 1.5e-41 140.2 0.0 1.2 1 0 0 1 1 1 1 Urease beta subunit DUF4232 PF14016.1 AIC15716.1 - 0.1 12.2 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4232) Urease_gamma PF00547.13 AIC15717.1 - 3.1e-44 149.0 0.1 3.4e-44 148.8 0.1 1.0 1 0 0 1 1 1 1 Urease, gamma subunit DUF929 PF06053.6 AIC15717.1 - 0.097 11.7 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF929) UT PF03253.9 AIC15719.1 - 6.1e-48 163.2 34.6 7.4e-21 74.3 6.3 3.1 2 1 1 3 3 3 3 Urea transporter SSF PF00474.12 AIC15720.1 - 1.2e-23 83.4 38.3 2.3e-23 82.5 26.6 1.5 1 0 0 1 1 1 1 Sodium:solute symporter family Usp PF00582.21 AIC15720.1 - 2.1e-22 79.8 0.1 3.9e-22 78.9 0.0 1.5 1 0 0 1 1 1 1 Universal stress protein family HTH_24 PF13412.1 AIC15721.1 - 0.063 12.6 1.1 8.9 5.7 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding ParBc PF02195.13 AIC15722.1 - 4.3e-20 71.6 0.4 4.9e-19 68.2 0.0 2.4 2 1 0 2 2 2 1 ParB-like nuclease domain KorB PF08535.5 AIC15722.1 - 1.5e-08 34.6 0.3 3.5e-08 33.5 0.1 1.7 2 0 0 2 2 2 1 KorB domain HTH_5 PF01022.15 AIC15722.1 - 0.0076 15.8 0.2 0.15 11.7 0.0 2.8 3 0 0 3 3 3 1 Bacterial regulatory protein, arsR family DUF2481 PF10654.4 AIC15722.1 - 0.037 13.7 0.3 0.092 12.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) GIDA PF01134.17 AIC15722.1 - 0.046 12.5 0.3 0.11 11.3 0.1 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF745 PF05335.8 AIC15722.1 - 0.082 12.4 2.0 0.13 11.7 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF2572 PF10833.3 AIC15722.1 - 0.53 9.6 4.5 0.21 11.0 0.9 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2572) Usp PF00582.21 AIC15725.1 - 8.6e-34 116.7 1.1 1e-33 116.4 0.7 1.1 1 0 0 1 1 1 1 Universal stress protein family ETF_QO PF05187.8 AIC15728.1 - 0.12 12.4 0.8 0.33 10.9 0.1 1.8 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase SSF PF00474.12 AIC15729.1 - 7.8e-30 103.8 28.9 7.8e-30 103.8 20.0 1.4 2 0 0 2 2 2 1 Sodium:solute symporter family DUF2011 PF09428.5 AIC15730.1 - 0.025 14.4 0.0 0.028 14.3 0.0 1.1 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) ParBc PF02195.13 AIC15731.1 - 3.4e-11 43.1 0.0 7.8e-11 41.9 0.0 1.6 1 0 0 1 1 1 1 ParB-like nuclease domain KorB PF08535.5 AIC15731.1 - 1.5e-05 25.0 0.3 7.8e-05 22.7 0.0 2.2 2 1 0 2 2 2 1 KorB domain HTH_23 PF13384.1 AIC15731.1 - 0.0051 16.4 0.0 0.013 15.1 0.0 1.7 1 0 0 1 1 1 1 Homeodomain-like domain CENP-B_N PF04218.8 AIC15731.1 - 0.013 14.8 0.0 0.034 13.5 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_Tnp_1 PF01527.15 AIC15731.1 - 0.036 14.0 0.1 1.3 9.0 0.0 2.5 2 0 0 2 2 2 0 Transposase HTH_28 PF13518.1 AIC15731.1 - 0.043 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain RHH_1 PF01402.16 AIC15731.1 - 0.044 13.6 0.1 3.2 7.7 0.0 3.1 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family HTH_IclR PF09339.5 AIC15731.1 - 0.13 11.8 0.0 0.27 10.8 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF123 PF01986.11 AIC15732.1 - 0.032 14.3 0.1 0.032 14.3 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function DUF123 Arginase PF00491.16 AIC15733.1 - 1e-76 257.9 0.0 1.2e-76 257.7 0.0 1.0 1 0 0 1 1 1 1 Arginase family Urease_gamma PF00547.13 AIC15734.1 - 1.2e-11 44.4 0.1 1.5e-11 44.1 0.1 1.1 1 0 0 1 1 1 1 Urease, gamma subunit ABC-3 PF00950.12 AIC15735.1 - 2.3e-67 226.9 31.4 2.7e-67 226.7 21.7 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.13 AIC15735.1 - 6e-09 35.1 30.9 1.3e-08 34.0 21.4 1.6 1 1 0 1 1 1 1 FecCD transport family ABC_tran PF00005.22 AIC15736.1 - 1.3e-28 100.0 0.0 1.9e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC15736.1 - 5.4e-16 59.3 0.0 3.1e-09 37.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AIC15736.1 - 0.00021 20.9 0.1 0.00049 19.7 0.1 1.6 1 0 0 1 1 1 1 Part of AAA domain SbcCD_C PF13558.1 AIC15736.1 - 0.00032 20.5 0.1 0.0053 16.6 0.0 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 AIC15736.1 - 0.00083 19.5 0.1 0.0027 17.8 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.1 AIC15736.1 - 0.001 18.6 0.0 0.0046 16.5 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AIC15736.1 - 0.0011 18.3 0.4 0.0036 16.7 0.1 1.8 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.1 AIC15736.1 - 0.0013 18.7 0.1 0.027 14.4 0.1 2.0 2 0 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 AIC15736.1 - 0.0017 18.5 0.1 0.016 15.4 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.14 AIC15736.1 - 0.0019 17.5 0.2 1.6 7.8 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 AIC15736.1 - 0.0049 16.3 0.1 0.01 15.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 AIC15736.1 - 0.0053 15.8 0.0 0.68 8.9 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_17 PF13207.1 AIC15736.1 - 0.0071 17.1 0.2 0.013 16.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.7 AIC15736.1 - 0.0074 15.9 0.1 0.014 15.0 0.1 1.4 1 0 0 1 1 1 1 NACHT domain AAA_10 PF12846.2 AIC15736.1 - 0.014 14.8 0.2 0.035 13.5 0.1 1.6 2 0 0 2 2 2 0 AAA-like domain AAA_18 PF13238.1 AIC15736.1 - 0.018 15.3 0.0 0.036 14.3 0.0 1.5 2 0 0 2 2 1 0 AAA domain Arch_ATPase PF01637.13 AIC15736.1 - 0.019 14.6 0.0 0.029 14.0 0.0 1.2 1 0 0 1 1 1 0 Archaeal ATPase AAA_23 PF13476.1 AIC15736.1 - 0.02 15.2 0.1 0.028 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.1 AIC15736.1 - 0.03 13.9 0.0 0.056 13.0 0.0 1.6 1 1 1 2 2 2 0 AAA domain AAA_33 PF13671.1 AIC15736.1 - 0.04 13.8 0.0 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF258 PF03193.11 AIC15736.1 - 0.049 12.8 0.0 0.08 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 DUF3987 PF13148.1 AIC15736.1 - 0.064 11.8 0.0 0.1 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) NB-ARC PF00931.17 AIC15736.1 - 0.065 12.0 0.5 0.2 10.4 0.3 1.7 2 0 0 2 2 2 0 NB-ARC domain MobB PF03205.9 AIC15736.1 - 0.065 12.9 0.1 0.11 12.1 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B T2SE PF00437.15 AIC15736.1 - 0.076 11.9 0.1 0.13 11.1 0.1 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_5 PF07728.9 AIC15736.1 - 0.083 12.6 0.2 1.1 8.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.16 AIC15736.1 - 0.089 11.9 0.1 0.21 10.7 0.0 1.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.10 AIC15736.1 - 0.094 12.4 0.1 0.36 10.5 0.0 1.9 2 0 0 2 2 2 0 NTPase cobW PF02492.14 AIC15736.1 - 0.11 11.9 0.3 0.19 11.1 0.2 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain DUF87 PF01935.12 AIC15736.1 - 0.17 11.6 0.2 0.29 10.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF87 TroA PF01297.12 AIC15737.1 - 7.8e-72 241.6 0.0 1.1e-71 241.1 0.0 1.1 1 0 0 1 1 1 1 Periplasmic solute binding protein family NB PF04159.8 AIC15739.1 - 0.0063 16.2 0.2 0.0067 16.1 0.1 1.1 1 0 0 1 1 1 1 NB glycoprotein NikR_C PF08753.6 AIC15741.1 - 2.1e-23 81.9 4.0 3.6e-23 81.2 2.8 1.4 1 0 0 1 1 1 1 NikR C terminal nickel binding domain Cpn60_TCP1 PF00118.19 AIC15743.1 - 1.9e-138 462.1 3.4 2.2e-138 461.9 2.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Urease_gamma PF00547.13 AIC15744.1 - 6.9e-47 157.5 0.0 7.6e-47 157.3 0.0 1.0 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.15 AIC15745.1 - 1.3e-41 140.4 0.0 1.5e-41 140.2 0.0 1.1 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_1 PF01979.15 AIC15746.1 - 4.7e-64 217.1 4.4 6.2e-64 216.7 3.1 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.15 AIC15746.1 - 2.5e-50 169.6 2.9 4.9e-50 168.7 2.0 1.5 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_5 PF13594.1 AIC15746.1 - 1.1e-06 28.3 8.9 1.9e-06 27.5 4.3 3.0 2 1 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 AIC15746.1 - 0.00084 18.6 5.7 0.04 13.1 1.2 3.0 1 1 0 2 2 2 2 Amidohydrolase family Amidohydro_4 PF13147.1 AIC15746.1 - 0.0019 18.3 0.9 0.16 12.0 0.5 2.4 2 0 0 2 2 2 1 Amidohydrolase CP2 PF04516.10 AIC15747.1 - 0.13 11.3 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 CP2 transcription factor Citrate_synt PF00285.16 AIC15748.1 - 8.8e-132 439.1 0.0 9.9e-132 438.9 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase Bac_luciferase PF00296.15 AIC15750.1 - 4.3e-62 209.9 0.0 5.2e-62 209.7 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Lactamase_B_2 PF12706.2 AIC15751.1 - 1.3e-07 31.3 0.2 1.4e-05 24.7 0.2 2.5 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 AIC15751.1 - 0.0051 16.5 0.0 0.016 14.8 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.7 AIC15751.1 - 0.022 14.5 0.0 0.049 13.4 0.0 1.6 1 0 0 1 1 1 0 RNA-metabolising metallo-beta-lactamase LytR_C PF13399.1 AIC15751.1 - 0.045 14.1 0.1 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 LytR cell envelope-related transcriptional attenuator DRMBL PF07522.9 AIC15751.1 - 0.12 12.3 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase Lactamase_B PF00753.22 AIC15751.1 - 4.7 6.8 6.8 52 3.4 4.7 2.2 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily Formyl_trans_N PF00551.14 AIC15752.1 - 4.5e-49 166.4 0.0 5.1e-49 166.2 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase MFS_1 PF07690.11 AIC15753.1 - 1.4e-33 116.1 47.8 2e-22 79.4 9.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily UNC-93 PF05978.11 AIC15753.1 - 0.00033 20.1 13.5 0.00082 18.8 2.8 2.3 2 0 0 2 2 2 2 Ion channel regulatory protein UNC-93 DUF1228 PF06779.9 AIC15753.1 - 0.0031 17.4 1.8 0.0031 17.4 1.2 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF1228) Ubie_methyltran PF01209.13 AIC15754.1 - 3.9e-23 81.7 0.0 4.4e-23 81.5 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.7 AIC15754.1 - 1.3e-17 64.0 0.0 2.2e-17 63.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15754.1 - 1.9e-12 47.7 0.0 2.9e-12 47.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15754.1 - 1.1e-11 44.6 0.0 1.3e-11 44.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15754.1 - 4e-11 42.7 0.0 5.9e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15754.1 - 7.3e-10 39.1 0.0 1.2e-09 38.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15754.1 - 1.1e-09 38.6 0.0 1.9e-09 37.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC15754.1 - 5.7e-06 26.3 0.1 1.2e-05 25.3 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC15754.1 - 0.00012 21.5 0.0 0.00019 20.8 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.10 AIC15754.1 - 0.0037 16.9 0.0 0.0056 16.3 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase Eno-Rase_NADH_b PF12242.3 AIC15754.1 - 0.0074 16.0 0.0 0.021 14.5 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DEAD PF00270.24 AIC15755.1 - 4.4e-33 114.1 0.0 9.1e-33 113.1 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF1998 PF09369.5 AIC15755.1 - 3.3e-12 46.8 0.2 1.1e-11 45.1 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.26 AIC15755.1 - 3.2e-11 42.9 0.0 5.4e-08 32.5 0.1 2.8 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.10 AIC15755.1 - 0.0079 16.0 0.0 0.021 14.6 0.0 1.7 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.18 AIC15755.1 - 0.011 14.5 0.0 0.016 14.0 0.0 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain zinc_ribbon_5 PF13719.1 AIC15755.1 - 0.019 14.5 0.9 0.019 14.5 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC15755.1 - 0.031 13.9 0.8 0.031 13.9 0.6 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-DNL PF05180.7 AIC15755.1 - 0.099 12.3 0.4 0.74 9.5 0.0 2.3 2 0 0 2 2 2 0 DNL zinc finger Topoisom_I_N PF02919.10 AIC15756.1 - 1.4e-63 214.1 1.1 1.4e-63 214.1 0.8 2.1 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.15 AIC15756.1 - 5.3e-53 179.5 8.2 1.1e-52 178.5 5.7 1.5 1 0 0 1 1 1 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.1 AIC15756.1 - 1e-22 79.5 3.5 1.3e-22 79.2 0.9 2.4 2 0 0 2 2 2 1 C-terminal topoisomerase domain DUF4226 PF10774.4 AIC15756.1 - 0.18 11.8 3.6 0.18 11.8 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4226) MarR_2 PF12802.2 AIC15757.1 - 2.6e-06 27.0 0.4 3.5e-05 23.3 0.0 2.6 2 0 0 2 2 2 1 MarR family DUF4366 PF14283.1 AIC15757.1 - 0.00043 19.7 2.0 0.004 16.5 0.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4366) DUF4398 PF14346.1 AIC15757.1 - 0.0015 18.5 7.1 0.0015 18.5 4.9 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4398) HTH_IclR PF09339.5 AIC15757.1 - 0.0027 17.2 0.0 0.0094 15.5 0.0 1.9 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.1 AIC15757.1 - 0.0066 15.8 0.0 0.017 14.4 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.14 AIC15757.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB TPR_12 PF13424.1 AIC15757.1 - 0.037 13.9 2.2 0.076 12.9 0.6 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TrwB_AAD_bind PF10412.4 AIC15757.1 - 0.072 11.7 3.0 0.1 11.1 2.1 1.2 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain HTH_20 PF12840.2 AIC15757.1 - 0.09 12.5 0.1 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1469 PF07332.6 AIC15757.1 - 0.15 11.7 9.5 0.089 12.5 1.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1469) TPR_16 PF13432.1 AIC15757.1 - 0.29 11.8 4.3 9.1 7.1 0.2 2.9 1 1 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.1 AIC15757.1 - 0.3 11.4 3.5 4.6 7.6 1.2 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat CBS PF00571.23 AIC15758.1 - 3.1e-18 65.2 2.9 4.2e-08 32.8 0.1 2.3 2 0 0 2 2 2 2 CBS domain zf-C2H2_4 PF13894.1 AIC15758.1 - 7.6e-05 22.7 0.1 0.00016 21.7 0.0 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC15758.1 - 0.0012 19.1 0.3 0.0023 18.1 0.0 1.7 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-Di19 PF05605.7 AIC15758.1 - 0.0094 16.0 0.0 0.02 15.0 0.0 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.2 AIC15758.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.21 AIC15759.1 - 0.00011 22.3 0.8 0.00015 21.8 0.6 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AIC15759.1 - 0.0034 17.6 0.6 0.0044 17.2 0.4 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.1 AIC15759.1 - 0.037 14.3 5.1 1.5 9.2 0.2 2.2 2 0 0 2 2 2 0 Zinc-finger double domain DUF1610 PF07754.6 AIC15759.1 - 0.042 13.9 0.1 0.066 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) Desulfoferrod_N PF06397.7 AIC15759.1 - 0.054 12.8 0.5 0.14 11.5 0.3 1.7 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Rubredoxin PF00301.15 AIC15759.1 - 0.13 12.1 0.0 0.18 11.7 0.0 1.2 1 0 0 1 1 1 0 Rubredoxin zf-met PF12874.2 AIC15759.1 - 0.14 12.4 0.7 0.18 12.0 0.5 1.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type eIF2A PF08662.6 AIC15760.1 - 0.00033 20.4 0.0 0.00056 19.6 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.7 AIC15760.1 - 0.0094 15.6 0.2 9.9 5.9 0.0 3.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Peptidase_S9_N PF02897.10 AIC15760.1 - 0.13 10.8 0.0 0.2 10.1 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Lyase_1 PF00206.15 AIC15762.1 - 2.7e-44 151.6 1.1 3.6e-44 151.2 0.1 1.7 2 0 0 2 2 2 1 Lyase ADSL_C PF10397.4 AIC15762.1 - 4.8e-20 71.3 0.2 1.1e-19 70.2 0.2 1.6 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus ASL_C PF08328.6 AIC15762.1 - 0.011 15.5 0.1 0.033 14.0 0.1 1.8 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal TPP_enzyme_N PF02776.13 AIC15762.1 - 0.1 12.0 0.7 0.71 9.3 0.1 2.5 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain RtcB PF01139.12 AIC15763.1 - 5.7e-148 493.3 0.0 6.5e-148 493.1 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB dsDNA_bind PF01984.15 AIC15764.1 - 4e-05 23.5 0.4 4.7e-05 23.3 0.3 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Ribosomal_S11 PF00411.14 AIC15766.1 - 4.7e-39 132.9 0.2 5.5e-39 132.7 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S11 Methyltransf_11 PF08241.7 AIC15767.1 - 9.8e-13 48.4 0.0 1.9e-12 47.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15767.1 - 2.1e-07 30.6 0.0 3e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15767.1 - 3.1e-05 23.7 0.0 4.1e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15767.1 - 0.00018 22.0 0.0 0.00028 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15767.1 - 0.00041 20.7 0.0 0.00072 19.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain DUF164 PF02591.10 AIC15769.1 - 0.066 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative zinc ribbon domain HATPase_c PF02518.21 AIC15771.1 - 6.4e-23 80.6 0.2 1.8e-22 79.1 0.0 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 AIC15771.1 - 2.1e-14 53.2 0.2 5.4e-14 51.9 0.2 1.8 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.1 AIC15771.1 - 1.1e-07 32.1 0.0 3.3e-07 30.6 0.0 1.8 1 1 0 1 1 1 1 PAS domain PAS PF00989.19 AIC15771.1 - 2.8e-05 23.8 0.0 0.00013 21.6 0.0 2.1 1 1 1 2 2 2 1 PAS fold PAS_8 PF13188.1 AIC15771.1 - 0.0079 16.0 0.0 0.058 13.2 0.0 2.4 2 0 0 2 2 2 1 PAS domain HATPase_c_3 PF13589.1 AIC15771.1 - 0.012 15.3 0.0 0.028 14.0 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_2 PF13581.1 AIC15771.1 - 0.021 14.5 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-like ATPase domain PAS_4 PF08448.5 AIC15771.1 - 0.028 14.4 0.0 0.27 11.3 0.0 2.2 2 0 0 2 2 2 0 PAS fold Response_reg PF00072.19 AIC15772.1 - 4.6e-14 52.3 0.1 6.5e-14 51.8 0.1 1.2 1 0 0 1 1 1 1 Response regulator receiver domain DUF2910 PF11139.3 AIC15774.1 - 1.3 8.0 11.4 8.7 5.4 8.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2910) Sina PF03145.11 AIC15775.1 - 0.016 14.8 0.1 0.016 14.8 0.1 1.1 1 0 0 1 1 1 0 Seven in absentia protein family XkdN PF08890.6 AIC15775.1 - 0.09 12.5 0.1 0.09 12.5 0.0 1.0 1 0 0 1 1 1 0 Phage XkdN-like protein zf-BED PF02892.10 AIC15775.1 - 0.28 10.9 2.2 3.3 7.5 0.1 2.2 2 0 0 2 2 2 0 BED zinc finger AIRS PF00586.19 AIC15776.1 - 3e-16 59.4 0.0 7.6e-16 58.1 0.0 1.7 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.17 AIC15776.1 - 2.7e-09 37.2 0.1 4.7e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain PGM_PMM_I PF02878.11 AIC15777.1 - 1.4e-24 86.1 0.0 3.1e-24 85.0 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.11 AIC15777.1 - 4.4e-17 62.1 0.1 9.5e-17 61.0 0.1 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.11 AIC15777.1 - 2.4e-14 53.5 0.1 4.8e-14 52.5 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.15 AIC15777.1 - 4.1e-07 29.9 0.0 1.3e-06 28.3 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain P-II PF00543.17 AIC15778.1 - 1.8e-07 31.5 0.1 2.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II Cpn60_TCP1 PF00118.19 AIC15779.1 - 5.6e-164 546.3 11.7 6.5e-164 546.1 8.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TraC PF07820.7 AIC15780.1 - 0.69 10.1 4.2 0.96 9.6 1.1 1.9 1 1 1 2 2 2 0 TraC-like protein zf-C2H2_4 PF13894.1 AIC15782.1 - 0.0018 18.4 0.5 0.014 15.6 0.1 2.2 2 0 0 2 2 2 1 C2H2-type zinc finger DUF1644 PF07800.7 AIC15782.1 - 0.04 13.7 0.5 2.8 7.7 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) zf-C2H2 PF00096.21 AIC15782.1 - 0.043 14.1 0.4 0.12 12.7 0.1 1.9 2 0 0 2 2 2 0 Zinc finger, C2H2 type Polysacc_deac_1 PF01522.16 AIC15784.1 - 7.2e-10 38.5 0.0 1.2e-09 37.8 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF308 PF03729.8 AIC15785.1 - 0.0031 17.4 15.0 0.0031 17.4 10.4 2.8 3 1 0 3 3 3 1 Short repeat of unknown function (DUF308) DUF2127 PF09900.4 AIC15785.1 - 0.0093 16.0 16.1 0.067 13.2 11.2 1.9 1 1 0 1 1 1 1 Predicted membrane protein (DUF2127) FixQ PF05545.6 AIC15785.1 - 1.3 8.6 0.0 1.3 8.6 0.0 2.8 3 1 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Tetraspannin PF00335.15 AIC15785.1 - 5.5 6.1 19.3 9.1 5.4 13.4 1.4 1 1 0 1 1 1 0 Tetraspanin family Ytp1 PF10355.4 AIC15785.1 - 7.1 5.7 10.9 0.32 10.1 3.5 1.7 2 1 0 2 2 2 0 Protein of unknown function (Ytp1) Ubiq-assoc PF09145.5 AIC15786.1 - 0.11 12.3 0.1 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-associated DUF482 PF04339.7 AIC15788.1 - 0.0084 15.0 1.3 0.0091 14.9 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF482 DUF2208 PF09973.4 AIC15789.1 - 0.04 13.1 0.4 0.042 13.0 0.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) TUG-UBL1 PF11470.3 AIC15789.1 - 0.067 13.1 0.0 0.086 12.7 0.0 1.2 1 0 0 1 1 1 0 GLUT4 regulating protein TUG Zn_ribbon_recom PF13408.1 AIC15791.1 - 0.065 13.4 0.0 0.078 13.2 0.0 1.2 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain DUF4451 PF14616.1 AIC15791.1 - 0.073 12.8 0.1 0.092 12.5 0.1 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) N6_N4_Mtase PF01555.13 AIC15793.1 - 1.2e-48 165.6 0.0 7.4e-48 163.0 0.0 1.8 1 1 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 AIC15793.1 - 8.3e-16 58.0 0.0 6.7e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain UPF0020 PF01170.13 AIC15793.1 - 3.9e-06 26.5 0.0 0.00075 19.1 0.0 2.3 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 MTS PF05175.9 AIC15793.1 - 5.5e-05 22.6 0.0 0.0038 16.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_18 PF12847.2 AIC15793.1 - 0.00091 19.7 0.0 0.028 14.9 0.0 2.6 3 0 0 3 3 3 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15793.1 - 0.025 14.1 0.0 0.05 13.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Nitroreductase PF00881.19 AIC15794.1 - 6e-25 87.9 0.0 1e-24 87.2 0.0 1.4 1 1 0 1 1 1 1 Nitroreductase family Methyltransf_4 PF02390.12 AIC15795.1 - 1.8e-08 33.6 0.0 3.8e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase HD PF01966.17 AIC15795.1 - 2.3e-05 24.4 0.0 5.6e-05 23.1 0.0 1.7 1 0 0 1 1 1 1 HD domain HxlR PF01638.12 AIC15796.1 - 5.3e-20 70.8 0.1 6.9e-20 70.4 0.0 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_24 PF13412.1 AIC15796.1 - 0.0022 17.3 0.0 0.004 16.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC15796.1 - 0.0099 15.5 0.0 0.017 14.7 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.17 AIC15796.1 - 0.033 13.9 0.0 0.061 13.0 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_20 PF12840.2 AIC15796.1 - 0.037 13.8 0.0 0.074 12.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Fe_dep_repress PF01325.14 AIC15796.1 - 0.056 13.3 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HHH_5 PF14520.1 AIC15796.1 - 0.084 13.0 0.0 0.18 12.0 0.0 1.6 1 1 0 1 1 1 0 Helix-hairpin-helix domain HTH_5 PF01022.15 AIC15796.1 - 0.13 11.9 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Glyoxalase_2 PF12681.2 AIC15797.1 - 7.1e-10 39.4 0.0 8.9e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 AIC15797.1 - 0.11 12.4 0.0 0.86 9.5 0.0 2.0 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HEAT_2 PF13646.1 AIC15799.1 - 2.2e-38 130.4 1.6 4.3e-16 58.9 0.2 2.1 1 1 2 3 3 3 3 HEAT repeats HEAT_EZ PF13513.1 AIC15799.1 - 9.4e-12 45.0 1.6 0.013 15.9 0.1 4.0 3 1 1 4 4 4 3 HEAT-like repeat HEAT_PBS PF03130.11 AIC15799.1 - 1.3e-11 43.8 0.3 0.077 13.5 0.0 4.1 4 0 0 4 4 4 3 PBS lyase HEAT-like repeat HEAT PF02985.17 AIC15799.1 - 1.4e-11 43.4 0.9 0.11 12.5 0.0 4.2 4 0 0 4 4 4 4 HEAT repeat Arm PF00514.18 AIC15799.1 - 4.6e-05 23.0 0.0 2.9 7.8 0.0 3.9 4 0 0 4 4 4 1 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.15 AIC15799.1 - 0.0084 14.4 0.4 0.16 10.2 0.3 2.1 1 1 0 1 1 1 1 Adaptin N terminal region DUF3385 PF11865.3 AIC15799.1 - 0.02 14.7 0.0 1.7 8.5 0.0 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF3385) DUF4042 PF13251.1 AIC15799.1 - 0.1 12.0 0.1 11 5.4 0.0 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4042) Cnd1 PF12717.2 AIC15799.1 - 0.13 12.1 0.9 12 5.6 0.1 2.9 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Rho_Binding PF08912.6 AIC15799.1 - 0.99 9.7 7.9 0.92 9.8 4.0 2.0 2 1 0 2 2 2 0 Rho Binding TatC PF00902.13 AIC15801.1 - 1.2e-55 188.2 21.3 1.4e-55 188.0 14.7 1.0 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) MttA_Hcf106 PF02416.11 AIC15802.1 - 1.7e-09 36.6 0.1 1.4e-08 33.7 0.1 2.0 2 0 0 2 2 2 1 mttA/Hcf106 family DUF4381 PF14316.1 AIC15802.1 - 0.033 14.2 0.0 0.046 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Lip_A_acyltrans PF03279.8 AIC15802.1 - 0.057 12.2 0.0 0.057 12.2 0.0 1.1 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase OAD_gamma PF04277.8 AIC15802.1 - 0.15 12.4 1.1 0.27 11.6 0.8 1.5 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF1297 PF06973.7 AIC15803.1 - 4.5e-75 251.1 0.1 5.9e-75 250.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.7 AIC15803.1 - 2.2e-46 156.6 0.0 6.5e-46 155.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF1246) ATP-grasp_4 PF13535.1 AIC15803.1 - 0.00083 19.1 0.0 0.0014 18.3 0.0 1.6 1 1 0 1 1 1 1 ATP-grasp domain DNase-RNase PF02577.9 AIC15804.1 - 1.1e-09 37.6 0.0 1.2e-09 37.4 0.0 1.1 1 0 0 1 1 1 1 Bifunctional nuclease MerT PF02411.10 AIC15805.1 - 0.013 15.3 3.5 0.013 15.3 2.4 2.8 2 1 0 2 2 2 0 MerT mercuric transport protein HAD PF12710.2 AIC15806.1 - 2.3e-14 53.9 0.1 2.8e-14 53.7 0.1 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AIC15806.1 - 1.5e-09 37.8 0.0 6.7e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AIC15806.1 - 4.5e-08 33.7 0.1 0.0004 20.8 0.0 2.1 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.1 AIC15806.1 - 4e-05 23.9 0.1 0.00046 20.4 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.7 AIC15806.1 - 0.00035 19.8 0.0 0.00086 18.5 0.0 1.7 1 1 0 1 1 1 1 Putative Phosphatase Cyclotide PF03784.8 AIC15806.1 - 0.057 13.2 0.8 0.1 12.4 0.6 1.3 1 0 0 1 1 1 0 Cyclotide family Hydrolase_like PF13242.1 AIC15806.1 - 0.072 12.8 0.2 0.23 11.1 0.1 1.9 2 1 0 2 2 2 0 HAD-hyrolase-like Tn7_Tnp_TnsA_C PF08721.6 AIC15807.1 - 0.11 12.5 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 TnsA endonuclease C terminal adh_short PF00106.20 AIC15812.1 - 2.1e-25 89.5 0.1 2.4e-25 89.3 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AIC15812.1 - 1e-15 58.1 0.0 1.3e-15 57.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AIC15812.1 - 1.5e-08 34.5 0.1 1.7e-08 34.3 0.1 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.5 AIC15812.1 - 0.0064 15.6 0.0 0.077 12.1 0.0 1.9 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) Eno-Rase_NADH_b PF12242.3 AIC15812.1 - 0.007 16.1 0.1 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase RmlD_sub_bind PF04321.12 AIC15812.1 - 0.011 14.5 0.1 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain Epimerase PF01370.16 AIC15812.1 - 0.039 13.3 0.1 0.049 13.0 0.0 1.3 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF2950 PF11453.3 AIC15813.1 - 0.058 12.3 0.1 0.063 12.2 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2950) SseB PF07179.7 AIC15814.1 - 0.12 12.2 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 SseB protein N-terminal domain DUF3367 PF11847.3 AIC15815.1 - 0.059 11.3 2.2 0.044 11.7 0.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3367) Trep_Strep PF09605.5 AIC15816.1 - 0.16 11.6 1.7 0.65 9.6 0.1 2.1 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) DUF4367 PF14285.1 AIC15816.1 - 0.9 8.8 4.1 0.16 11.2 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) Ribosomal_S2 PF00318.15 AIC15818.1 - 0.05 12.8 0.0 0.059 12.5 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 zf-A20 PF01754.11 AIC15818.1 - 0.27 10.8 7.6 0.75 9.4 3.0 2.6 2 1 0 2 2 2 0 A20-like zinc finger DUF1351 PF07083.6 AIC15820.1 - 0.016 14.8 0.1 0.021 14.4 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1351) Prim_Zn_Ribbon PF08273.7 AIC15823.1 - 0.73 9.9 4.7 5.6 7.1 3.2 2.0 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase DnaJ_CXXCXGXG PF00684.14 AIC15824.1 - 2.5e-05 24.2 0.5 4e-05 23.5 0.3 1.4 1 1 0 1 1 1 1 DnaJ central domain zf-TFIIB PF13453.1 AIC15824.1 - 0.058 12.6 1.0 0.083 12.1 0.7 1.4 1 1 0 1 1 1 0 Transcription factor zinc-finger A2L_zn_ribbon PF08792.5 AIC15824.1 - 0.43 10.1 2.4 0.87 9.1 0.2 2.0 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-C2H2 PF00096.21 AIC15825.1 - 0.0023 18.1 0.0 0.003 17.8 0.0 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 AIC15825.1 - 0.0029 17.4 0.0 0.0039 17.0 0.0 1.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.1 AIC15825.1 - 0.019 15.2 0.0 0.023 14.9 0.0 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AIC15825.1 - 0.021 14.9 0.0 0.031 14.4 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_3 PF13878.1 AIC15825.1 - 0.054 13.0 0.0 0.063 12.8 0.0 1.2 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO DUF1126 PF06565.7 AIC15825.1 - 0.081 12.4 0.0 1.3 8.5 0.0 2.1 2 0 0 2 2 2 0 Repeat of unknown function (DUF1126) UbiA PF01040.13 AIC15826.1 - 0.013 14.7 0.2 0.013 14.7 0.1 1.7 2 0 0 2 2 2 0 UbiA prenyltransferase family HN PF00423.14 AIC15827.1 - 0.06 11.6 0.1 0.069 11.4 0.0 1.1 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase DUF462 PF04315.7 AIC15829.1 - 0.057 12.7 0.0 0.057 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF462 ABM PF03992.11 AIC15830.1 - 1.5e-07 31.3 0.1 2.1e-07 30.8 0.1 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase COG7 PF10191.4 AIC15830.1 - 0.0022 16.0 0.1 0.0025 15.8 0.1 1.0 1 0 0 1 1 1 1 Golgi complex component 7 (COG7) DUF1374 PF07118.6 AIC15830.1 - 0.073 13.1 0.5 0.11 12.5 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1374) GTP_EFTU PF00009.22 AIC15831.1 - 4.6e-50 169.6 0.0 8.5e-50 168.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.13 AIC15831.1 - 2.1e-25 88.6 0.1 6.8e-25 86.9 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.1 AIC15831.1 - 4.3e-19 68.1 0.3 8e-19 67.2 0.2 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.19 AIC15831.1 - 2e-18 66.0 0.0 4.7e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.20 AIC15831.1 - 1.6e-11 44.1 0.1 5.2e-11 42.5 0.0 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 VitK2_biosynth PF02621.9 AIC15832.1 - 7.7e-68 228.3 0.0 8.6e-68 228.2 0.0 1.0 1 0 0 1 1 1 1 Menaquinone biosynthesis Phosphonate-bd PF12974.2 AIC15832.1 - 0.00023 20.6 0.1 0.00063 19.1 0.0 1.6 2 1 0 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein LAGLIDADG_WhiA PF14527.1 AIC15833.1 - 0.13 12.1 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain FAA_hydrolase PF01557.13 AIC15834.1 - 2.7e-69 232.9 0.0 1.5e-68 230.5 0.0 1.8 2 0 0 2 2 2 1 Fumarylacetoacetate (FAA) hydrolase family SpoA PF01052.15 AIC15834.1 - 0.013 15.0 0.1 0.031 13.8 0.1 1.6 1 1 0 1 1 1 0 Surface presentation of antigens (SPOA) DUF2437 PF10370.4 AIC15834.1 - 0.077 13.3 0.2 0.89 9.9 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2437) CitMHS PF03600.11 AIC15835.1 - 3.3e-53 180.5 34.2 3.3e-53 180.5 23.7 2.4 1 1 1 2 2 2 1 Citrate transporter ArsB PF02040.10 AIC15835.1 - 3e-24 85.7 35.8 3e-24 85.7 24.8 1.6 1 1 1 2 2 2 1 Arsenical pump membrane protein Na_sulph_symp PF00939.14 AIC15835.1 - 2.7e-11 43.0 41.4 3.5e-07 29.4 10.0 2.3 1 1 1 2 2 2 2 Sodium:sulfate symporter transmembrane region Isochorismatase PF00857.15 AIC15836.1 - 6.4e-32 110.8 0.0 1.7e-31 109.4 0.0 1.7 2 0 0 2 2 2 1 Isochorismatase family Transp_cyt_pur PF02133.10 AIC15837.1 - 1.3e-19 70.1 47.8 1.9e-19 69.5 33.1 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin AIRC PF00731.15 AIC15838.1 - 7.3e-49 164.8 0.1 8.3e-49 164.7 0.1 1.0 1 0 0 1 1 1 1 AIR carboxylase Hydrolase_3 PF08282.7 AIC15838.1 - 0.072 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Fe-ADH PF00465.14 AIC15838.1 - 0.1 11.1 0.0 0.36 9.4 0.0 1.7 2 0 0 2 2 2 0 Iron-containing alcohol dehydrogenase Amidase PF01425.16 AIC15840.1 - 8.2e-129 430.2 0.0 9.3e-129 430.1 0.0 1.0 1 0 0 1 1 1 1 Amidase DUF3270 PF11674.3 AIC15841.1 - 0.049 13.6 0.2 0.058 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) DUF4191 PF13829.1 AIC15841.1 - 0.087 11.9 0.5 0.098 11.7 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF3040 PF11239.3 AIC15841.1 - 0.091 12.8 1.0 0.11 12.6 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) Sre PF03125.13 AIC15841.1 - 0.16 10.8 2.1 0.21 10.4 1.5 1.1 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor Bmp PF02608.9 AIC15842.1 - 1.8e-53 181.2 1.1 3e-53 180.5 0.7 1.3 1 0 0 1 1 1 1 Basic membrane protein BPD_transp_2 PF02653.11 AIC15843.1 - 1e-41 142.6 32.9 1.4e-41 142.2 22.8 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component BPD_transp_2 PF02653.11 AIC15844.1 - 1.4e-40 138.9 34.7 1.4e-40 138.9 24.0 1.9 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component ABC_tran PF00005.22 AIC15845.1 - 2.9e-52 176.6 0.1 3.6e-30 105.0 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.1 AIC15845.1 - 3.1e-07 30.6 0.3 5.5e-05 23.2 0.2 2.7 2 1 0 2 2 2 1 AAA domain DUF258 PF03193.11 AIC15845.1 - 8.1e-05 21.8 0.4 0.002 17.3 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 AIC15845.1 - 0.00021 20.4 0.2 0.04 12.9 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 AIC15845.1 - 0.00032 20.1 0.0 0.00082 18.8 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.1 AIC15845.1 - 0.00077 19.8 0.0 0.0015 18.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.14 AIC15845.1 - 0.039 13.1 0.2 0.57 9.3 0.0 2.4 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain IstB_IS21 PF01695.12 AIC15845.1 - 0.066 12.6 0.5 6.5 6.1 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein Bac_DnaA PF00308.13 AIC15845.1 - 0.11 12.1 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein Ligase_CoA PF00549.14 AIC15846.1 - 1.9e-41 141.1 0.2 1.7e-39 134.8 0.0 2.3 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.14 AIC15846.1 - 1e-08 35.5 0.4 1e-06 29.1 0.3 2.8 2 0 0 2 2 2 1 CoA binding domain DUF2877 PF11392.3 AIC15848.1 - 1.6e-12 47.6 0.0 3e-12 46.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2877) Bmp PF02608.9 AIC15849.1 - 3.1e-52 177.2 0.7 5.3e-26 91.0 0.2 2.5 2 0 0 2 2 2 2 Basic membrane protein AA_kinase PF00696.23 AIC15849.1 - 8.8e-27 94.1 0.1 8.7e-15 54.9 0.0 2.8 2 1 1 3 3 3 2 Amino acid kinase family DUF1116 PF06545.6 AIC15850.1 - 7.8e-79 263.7 0.1 1.1e-78 263.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1116) Radical_SAM PF04055.16 AIC15851.1 - 3.6e-15 56.5 0.1 6.9e-15 55.6 0.1 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Radical_SAM PF04055.16 AIC15852.1 - 4.4e-17 62.7 0.1 7.4e-17 62.0 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.19 AIC15853.1 - 1.7e-11 43.9 0.0 2.2e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.1 AIC15853.1 - 6.7e-07 29.4 0.0 1.9e-05 24.7 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AIC15853.1 - 2.3e-05 24.2 0.1 0.00016 21.5 0.0 2.3 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 AIC15853.1 - 3.1e-05 24.0 0.0 0.00038 20.5 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain UbiD PF01977.11 AIC15854.1 - 2.5e-153 510.3 0.7 2.9e-153 510.1 0.5 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DDE_Tnp_IS240 PF13610.1 AIC15856.1 - 8.9e-10 38.6 0.0 1.4e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC15856.1 - 2.3e-05 24.4 0.2 4.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC15856.1 - 0.00017 20.8 0.6 0.00033 19.9 0.3 1.6 1 1 0 1 1 1 1 Transposase IS66 family DUF4206 PF13901.1 AIC15856.1 - 0.029 13.9 0.7 0.04 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) Ribosomal_S24e PF01282.14 AIC15857.1 - 3.5e-09 36.3 0.4 5e-09 35.8 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein S24e Ribosomal_S27 PF01599.14 AIC15858.1 - 1.4e-21 76.0 7.1 1.9e-21 75.6 4.9 1.2 1 0 0 1 1 1 1 Ribosomal protein S27a GCC2_GCC3 PF07699.8 AIC15858.1 - 0.0023 17.4 2.2 0.0029 17.1 1.5 1.2 1 0 0 1 1 1 1 GCC2 and GCC3 DUF1451 PF07295.6 AIC15858.1 - 0.0041 16.8 1.1 0.0043 16.8 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1451) DZR PF12773.2 AIC15858.1 - 0.0042 16.8 1.2 0.0059 16.4 0.9 1.2 1 0 0 1 1 1 1 Double zinc ribbon Ribosomal_L37e PF01907.14 AIC15858.1 - 0.0067 16.2 3.6 0.009 15.7 2.5 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e DUF2082 PF09855.4 AIC15858.1 - 0.012 15.4 6.4 0.015 15.1 0.2 2.4 2 1 1 3 3 3 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) NCD3G PF07562.9 AIC15858.1 - 0.013 15.2 0.6 0.018 14.7 0.4 1.3 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR GFA PF04828.9 AIC15858.1 - 0.014 15.2 2.4 0.2 11.5 0.1 2.0 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme IBR PF01485.16 AIC15858.1 - 0.016 15.1 0.8 0.019 14.8 0.5 1.2 1 0 0 1 1 1 0 IBR domain Nudix_N_2 PF14803.1 AIC15858.1 - 0.021 14.4 1.2 0.14 11.8 0.9 2.0 1 1 0 1 1 1 0 Nudix N-terminal A2L_zn_ribbon PF08792.5 AIC15858.1 - 0.024 14.1 2.4 0.041 13.3 1.6 1.4 1 1 0 1 1 1 0 A2L zinc ribbon domain DUF2387 PF09526.5 AIC15858.1 - 0.027 14.3 1.7 1.4 8.8 0.1 2.2 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) OrfB_Zn_ribbon PF07282.6 AIC15858.1 - 0.029 14.0 1.6 0.039 13.5 1.1 1.3 1 0 0 1 1 1 0 Putative transposase DNA-binding domain HypA PF01155.14 AIC15858.1 - 0.036 13.7 0.5 0.039 13.6 0.3 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Zn_Tnp_IS1595 PF12760.2 AIC15858.1 - 0.046 13.5 4.5 0.34 10.7 3.1 2.0 1 1 2 3 3 3 0 Transposase zinc-ribbon domain C1_1 PF00130.17 AIC15858.1 - 0.048 13.3 1.7 0.067 12.9 1.2 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) DNA_RNApol_7kD PF03604.8 AIC15858.1 - 0.071 12.5 1.6 0.14 11.6 1.1 1.5 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_2 PF13240.1 AIC15858.1 - 0.14 11.6 3.9 3 7.4 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF1936 PF09151.5 AIC15858.1 - 0.22 11.0 1.8 7.1 6.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1936) zf-C2H2 PF00096.21 AIC15858.1 - 0.69 10.3 2.8 4.5 7.8 0.2 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_2 PF13465.1 AIC15858.1 - 0.81 10.0 3.1 3.8 7.9 0.2 2.3 2 0 0 2 2 2 0 Zinc-finger double domain zf-ribbon_3 PF13248.1 AIC15858.1 - 1.1 8.5 5.4 9 5.6 3.7 2.1 1 1 1 2 2 2 0 zinc-ribbon domain FeS PF04060.8 AIC15858.1 - 3.5 7.2 7.5 0.25 10.9 0.5 2.3 2 0 0 2 2 2 0 Putative Fe-S cluster NTP_transf_2 PF01909.18 AIC15859.1 - 1.7e-07 31.4 0.1 3.7e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Kdo PF06293.9 AIC15859.1 - 0.00018 20.6 0.0 0.00051 19.1 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Nuc-transf PF10127.4 AIC15859.1 - 0.0042 16.4 0.1 0.028 13.7 0.0 2.2 2 0 0 2 2 2 1 Predicted nucleotidyltransferase SBP_bac_5 PF00496.17 AIC15861.1 - 0.016 14.0 0.3 0.032 13.0 0.1 1.5 2 0 0 2 2 2 0 Bacterial extracellular solute-binding proteins, family 5 Middle Tetraspannin PF00335.15 AIC15862.1 - 0.067 12.4 2.8 0.086 12.0 1.9 1.1 1 0 0 1 1 1 0 Tetraspanin family Peroxin-22 PF12827.2 AIC15862.1 - 0.14 11.9 4.1 0.27 10.9 0.2 2.1 2 0 0 2 2 2 0 Peroxisomal biogenesis protein family Baculo_LEF-10 PF07206.6 AIC15862.1 - 0.43 10.2 6.0 4.6 6.9 0.2 2.3 2 0 0 2 2 2 0 Baculovirus late expression factor 10 (LEF-10) Agenet PF05641.7 AIC15862.1 - 3.7 7.7 7.6 5.4 7.2 0.4 2.3 1 1 1 2 2 2 0 Agenet domain C5-epim_C PF06662.8 AIC15863.1 - 1.4e-30 106.0 1.7 1.9e-30 105.5 1.2 1.1 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.8 AIC15863.1 - 0.00011 21.3 0.3 1.5 7.7 0.0 3.0 1 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 THUMP PF02926.12 AIC15864.1 - 3.9e-06 26.8 0.0 9.5e-06 25.5 0.0 1.6 1 0 0 1 1 1 1 THUMP domain SRP54 PF00448.17 AIC15865.1 - 1.2e-70 237.0 0.2 1.9e-70 236.3 0.1 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.14 AIC15865.1 - 4.3e-27 94.4 9.8 3.6e-26 91.4 4.5 2.6 2 0 0 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.14 AIC15865.1 - 9e-15 54.5 1.2 1.5e-14 53.8 0.2 1.9 2 0 0 2 2 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.18 AIC15865.1 - 6e-10 38.8 0.1 2.5e-09 36.8 0.1 2.1 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MobB PF03205.9 AIC15865.1 - 3.6e-06 26.7 0.2 8.7e-06 25.4 0.1 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B cobW PF02492.14 AIC15865.1 - 5.3e-06 26.0 0.3 3.4e-05 23.3 0.2 2.1 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain AAA_22 PF13401.1 AIC15865.1 - 3.2e-05 24.0 0.1 0.00033 20.7 0.0 2.4 2 0 0 2 2 2 1 AAA domain ArgK PF03308.11 AIC15865.1 - 3.8e-05 22.6 1.4 5.2e-05 22.1 0.1 1.9 2 1 0 2 2 2 1 ArgK protein APS_kinase PF01583.15 AIC15865.1 - 0.0003 20.4 0.1 0.00066 19.3 0.1 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase MipZ PF09140.6 AIC15865.1 - 0.00042 19.4 0.3 0.025 13.6 0.2 2.4 1 1 0 1 1 1 1 ATPase MipZ AAA_16 PF13191.1 AIC15865.1 - 0.00064 19.7 0.0 0.0021 18.0 0.0 2.0 2 0 0 2 2 1 1 AAA ATPase domain AAA_33 PF13671.1 AIC15865.1 - 0.00095 19.0 0.0 0.0022 17.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 AIC15865.1 - 0.0018 18.5 0.0 0.021 15.0 0.0 2.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 AIC15865.1 - 0.0019 18.9 0.1 0.006 17.4 0.1 2.0 1 1 0 1 1 1 1 AAA domain Mur_ligase_M PF08245.7 AIC15865.1 - 0.0026 17.8 0.0 0.0062 16.6 0.0 1.7 1 0 0 1 1 1 1 Mur ligase middle domain KTI12 PF08433.5 AIC15865.1 - 0.0027 16.9 0.0 0.0057 15.8 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_10 PF12846.2 AIC15865.1 - 0.0032 16.9 0.2 0.0079 15.6 0.2 2.0 1 1 0 1 1 1 1 AAA-like domain AAA_25 PF13481.1 AIC15865.1 - 0.0033 16.8 0.1 0.0084 15.5 0.1 1.7 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.12 AIC15865.1 - 0.0046 16.3 0.2 0.011 15.1 0.1 1.6 1 0 0 1 1 1 1 Thymidylate kinase ArsA_ATPase PF02374.10 AIC15865.1 - 0.0058 15.7 2.5 0.023 13.7 0.1 2.8 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_18 PF13238.1 AIC15865.1 - 0.008 16.4 0.4 0.029 14.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.10 AIC15865.1 - 0.0086 15.7 0.4 0.03 14.0 0.3 2.0 1 1 0 1 1 1 1 NTPase AAA_19 PF13245.1 AIC15865.1 - 0.01 15.5 0.1 0.029 14.1 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain LpxK PF02606.9 AIC15865.1 - 0.011 14.6 0.6 0.023 13.6 0.4 1.4 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase 6PF2K PF01591.13 AIC15865.1 - 0.012 14.7 0.0 0.031 13.3 0.0 1.8 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_30 PF13604.1 AIC15865.1 - 0.013 15.1 0.7 0.042 13.4 0.1 2.2 2 1 0 2 2 1 0 AAA domain PduV-EutP PF10662.4 AIC15865.1 - 0.026 14.0 0.2 5 6.6 0.1 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.7 AIC15865.1 - 0.045 12.8 0.0 0.091 11.8 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_5 PF07728.9 AIC15865.1 - 0.048 13.3 0.5 0.23 11.1 0.1 2.3 2 1 1 3 3 2 0 AAA domain (dynein-related subfamily) ATP_bind_1 PF03029.12 AIC15865.1 - 0.052 13.0 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_26 PF13500.1 AIC15865.1 - 0.059 12.9 0.1 0.35 10.4 0.1 2.3 1 1 0 1 1 1 0 AAA domain Arch_fla_DE PF04659.8 AIC15865.1 - 0.065 13.0 0.0 13 5.6 0.0 2.4 2 0 0 2 2 2 0 Archaeal flagella protein AAA_28 PF13521.1 AIC15865.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.17 AIC15865.1 - 0.1 12.7 0.0 0.56 10.4 0.0 2.3 1 1 0 1 1 1 0 RNA helicase LytR_C PF13399.1 AIC15865.1 - 0.12 12.8 0.2 0.47 10.8 0.0 2.1 2 0 0 2 2 1 0 LytR cell envelope-related transcriptional attenuator NACHT PF05729.7 AIC15865.1 - 0.17 11.5 0.9 0.41 10.2 0.3 1.9 2 0 0 2 2 1 0 NACHT domain ATP_bind_4 PF01902.12 AIC15866.1 - 9.3e-61 204.9 0.0 1.1e-60 204.7 0.0 1.0 1 0 0 1 1 1 1 ATP-binding region QueC PF06508.8 AIC15866.1 - 0.017 14.4 0.0 0.024 13.9 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 AIC15866.1 - 0.084 11.4 0.0 0.11 10.9 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase ThiI PF02568.9 AIC15866.1 - 0.14 11.6 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine biosynthesis protein (ThiI) Ub-Mut7C PF14451.1 AIC15866.1 - 0.14 11.6 0.0 0.32 10.5 0.0 1.6 1 0 0 1 1 1 0 Mut7-C ubiquitin ABC_tran PF00005.22 AIC15867.1 - 4.2e-32 111.3 0.0 5.5e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.7 AIC15867.1 - 9.9e-07 29.0 0.0 1.7e-06 28.2 0.0 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_16 PF13191.1 AIC15867.1 - 1.7e-05 24.8 0.1 3.6e-05 23.8 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.7 AIC15867.1 - 7.4e-05 21.9 0.0 0.00015 20.9 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_22 PF13401.1 AIC15867.1 - 9.8e-05 22.5 0.1 0.00055 20.0 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.1 AIC15867.1 - 0.0002 21.4 0.0 0.041 13.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AIC15867.1 - 0.00042 19.9 0.0 0.0011 18.7 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain UPF0079 PF02367.12 AIC15867.1 - 0.00069 19.2 0.0 0.0012 18.4 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_29 PF13555.1 AIC15867.1 - 0.0025 17.2 0.0 0.0048 16.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.24 AIC15867.1 - 0.0034 17.5 0.0 0.0058 16.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.1 AIC15867.1 - 0.0039 17.4 0.0 0.0063 16.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AIC15867.1 - 0.006 16.0 0.0 0.0083 15.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain T2SE PF00437.15 AIC15867.1 - 0.0074 15.2 0.1 0.017 13.9 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein TIP49 PF06068.8 AIC15867.1 - 0.0093 14.7 0.0 0.013 14.2 0.0 1.3 1 0 0 1 1 1 1 TIP49 C-terminus AAA_5 PF07728.9 AIC15867.1 - 0.011 15.4 0.0 0.033 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) GvpD PF07088.6 AIC15867.1 - 0.017 13.4 0.0 0.023 13.0 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein DUF258 PF03193.11 AIC15867.1 - 0.02 14.0 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 SRP54 PF00448.17 AIC15867.1 - 0.033 13.6 0.0 0.052 12.9 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_17 PF13207.1 AIC15867.1 - 0.035 14.9 0.1 0.069 13.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.1 AIC15867.1 - 0.045 13.8 0.1 0.14 12.1 0.1 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain APS_kinase PF01583.15 AIC15867.1 - 0.054 13.1 0.0 0.09 12.4 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase DEAD PF00270.24 AIC15867.1 - 0.055 12.9 0.1 0.14 11.6 0.0 1.7 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_33 PF13671.1 AIC15867.1 - 0.064 13.1 0.1 0.086 12.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain PRK PF00485.13 AIC15867.1 - 0.07 12.6 0.1 0.12 11.9 0.1 1.5 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_30 PF13604.1 AIC15867.1 - 0.075 12.5 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.21 AIC15867.1 - 0.076 12.4 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain MobB PF03205.9 AIC15867.1 - 0.092 12.4 0.2 0.21 11.2 0.0 1.8 2 0 0 2 2 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 AIC15867.1 - 0.098 12.0 0.0 0.41 10.0 0.0 1.8 1 1 1 2 2 2 0 AAA-like domain NACHT PF05729.7 AIC15867.1 - 0.1 12.2 0.0 0.2 11.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain SBP_bac_5 PF00496.17 AIC15868.1 - 2.5e-19 69.3 0.2 2.5e-19 69.3 0.1 3.2 3 1 0 3 3 3 1 Bacterial extracellular solute-binding proteins, family 5 Middle Gmad2 PF10648.4 AIC15868.1 - 0.018 15.2 0.0 0.058 13.5 0.0 1.9 1 0 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination BPD_transp_1 PF00528.17 AIC15869.1 - 4.3e-37 127.4 14.1 4.3e-37 127.4 9.8 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.17 AIC15870.1 - 6.1e-27 94.3 9.6 1.5e-26 93.0 6.7 1.7 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.2 AIC15870.1 - 0.0071 15.6 0.0 0.026 13.8 0.0 1.9 1 0 0 1 1 1 1 N-terminal TM domain of oligopeptide transport permease C DUF1634 PF07843.6 AIC15870.1 - 2.6 7.7 9.9 0.21 11.2 1.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1634) eIF-5a PF01287.15 AIC15871.1 - 6e-10 38.9 1.5 8.1e-10 38.5 1.1 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold EFP_N PF08207.7 AIC15871.1 - 1.1e-07 31.5 0.0 1.4e-06 28.0 0.0 2.2 2 0 0 2 2 2 1 Elongation factor P (EF-P) KOW-like domain KOW PF00467.24 AIC15871.1 - 0.034 13.8 0.6 0.097 12.4 0.0 2.1 2 0 0 2 2 2 0 KOW motif EFP PF01132.15 AIC15871.1 - 0.041 13.5 0.0 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 Elongation factor P (EF-P) OB domain CorA PF01544.13 AIC15874.1 - 8.1e-58 195.7 0.4 9.2e-58 195.5 0.3 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein ABC2_membrane_4 PF12730.2 AIC15874.1 - 0.051 12.7 2.5 0.086 11.9 1.7 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein ALAD PF00490.16 AIC15875.1 - 7.2e-114 380.0 2.5 8.6e-114 379.7 1.7 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase B12-binding PF02310.14 AIC15875.1 - 0.079 12.8 0.1 1.5 8.7 0.0 2.4 2 0 0 2 2 2 0 B12 binding domain Aldedh PF00171.17 AIC15876.1 - 2.1e-146 487.9 0.2 2.3e-146 487.7 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 AIC15876.1 - 0.0013 17.5 0.0 0.0019 17.0 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) ADH_N PF08240.7 AIC15878.1 - 7.2e-34 115.8 0.3 1.2e-33 115.1 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 AIC15878.1 - 2.2e-28 98.4 0.4 2.2e-28 98.4 0.2 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.1 AIC15878.1 - 1.5e-12 48.5 0.5 5.5e-12 46.6 0.0 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.16 AIC15878.1 - 0.0074 15.8 1.2 0.013 15.0 0.8 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox PF00070.22 AIC15878.1 - 0.013 15.8 0.4 0.59 10.5 0.5 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase OCD_Mu_crystall PF02423.10 AIC15878.1 - 0.016 13.9 0.2 0.028 13.1 0.1 1.4 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family TrkA_N PF02254.13 AIC15878.1 - 0.017 15.0 0.2 0.036 14.0 0.2 1.5 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.14 AIC15878.1 - 0.021 13.9 0.4 0.049 12.7 0.2 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.11 AIC15878.1 - 0.06 12.6 0.1 0.095 12.0 0.1 1.3 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase Spermine_synth PF01564.12 AIC15878.1 - 0.1 11.4 0.2 0.16 10.8 0.2 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase 3HCDH_N PF02737.13 AIC15878.1 - 0.15 11.7 1.0 0.26 10.9 0.7 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DUF488 PF04343.8 AIC15879.1 - 3.9e-26 91.8 0.1 4.3e-26 91.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF488 Myb_DNA-bind_2 PF08914.6 AIC15879.1 - 0.031 14.0 0.8 0.07 12.9 0.3 1.8 2 0 0 2 2 2 0 Rap1 Myb domain Pox_A14 PF05767.7 AIC15880.1 - 0.13 12.2 3.5 0.32 10.9 0.0 2.6 2 1 0 2 2 2 0 Poxvirus virion envelope protein A14 DUF998 PF06197.8 AIC15880.1 - 2.1 7.6 11.4 18 4.5 8.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF998) IncA PF04156.9 AIC15880.1 - 8.8 5.8 6.9 1.1e+02 2.3 0.0 2.1 2 0 0 2 2 2 0 IncA protein Lyase_1 PF00206.15 AIC15881.1 - 4.7e-93 311.8 0.5 5.9e-93 311.4 0.4 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.4 AIC15881.1 - 3.8e-19 68.4 2.3 5.4e-19 67.9 0.4 2.3 2 0 0 2 2 2 1 Fumarase C C-terminus DUF1062 PF06353.7 AIC15881.1 - 0.16 12.1 1.4 0.3 11.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1062) Acetyltransf_3 PF13302.1 AIC15882.1 - 8.8e-34 116.6 0.0 1.1e-33 116.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AIC15882.1 - 1.2e-21 77.2 0.1 1.5e-21 76.9 0.1 1.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.19 AIC15882.1 - 1.6e-10 40.8 0.1 2.4e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.1 AIC15882.1 - 7.6e-06 25.8 0.0 1.5e-05 24.9 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2079 PF09852.4 AIC15883.1 - 0.034 12.8 3.8 0.041 12.6 2.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) SdpI PF13630.1 AIC15883.1 - 2.2 8.0 15.1 2.7 7.7 0.8 3.1 1 1 2 3 3 3 0 SdpI/YhfL protein family DUF2964 PF11177.3 AIC15883.1 - 3.8 7.5 13.8 5.7 6.9 3.4 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF2964) DUF2182 PF09948.4 AIC15884.1 - 1.3e-45 155.7 21.6 2.5e-41 141.7 9.2 2.7 3 0 0 3 3 3 2 Predicted metal-binding integral membrane protein (DUF2182) EmrE PF13536.1 AIC15884.1 - 0.0047 17.1 8.5 0.0047 17.1 5.9 3.2 2 1 0 3 3 3 1 Multidrug resistance efflux transporter zf-DHHC PF01529.15 AIC15884.1 - 2.5 7.4 4.2 3.9 6.8 0.1 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF1326 PF07040.6 AIC15885.1 - 3.1e-50 170.5 0.0 3.6e-50 170.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) DUF1326 PF07040.6 AIC15887.1 - 1.4e-56 191.2 0.0 1.6e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) 2-Hacid_dh_C PF02826.14 AIC15889.1 - 6.2e-67 224.1 0.0 2.3e-66 222.3 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.25 AIC15889.1 - 3.1e-29 101.1 0.5 3.5e-29 100.9 0.3 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.10 AIC15889.1 - 6.2e-07 29.3 0.4 5.2e-06 26.4 0.0 2.1 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.16 AIC15889.1 - 0.015 15.1 0.1 0.098 12.4 0.0 2.1 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Ribosomal_L15e PF00827.12 AIC15890.1 - 2e-49 167.6 3.1 2.4e-49 167.4 2.1 1.0 1 0 0 1 1 1 1 Ribosomal L15 zf-CDGSH PF09360.5 AIC15892.1 - 1.5e-31 107.9 4.0 3.3e-17 62.0 0.2 2.7 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type Fer4_19 PF06902.6 AIC15892.1 - 2.4e-07 30.4 0.1 1e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 Divergent 4Fe-4S mono-cluster Tecti-min-caps PF09300.5 AIC15892.1 - 0.14 12.0 0.0 0.36 10.6 0.0 1.6 2 0 0 2 2 2 0 Tectiviridae, minor capsid ADH_zinc_N_2 PF13602.1 AIC15893.1 - 3.8e-25 89.2 0.4 1.3e-24 87.4 0.0 2.0 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.21 AIC15893.1 - 4.6e-18 65.0 0.1 8.5e-18 64.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AIC15893.1 - 2.6e-11 43.2 0.0 7.6e-11 41.7 0.0 1.7 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain NAD_binding_10 PF13460.1 AIC15893.1 - 0.012 15.6 0.1 0.019 14.9 0.1 1.4 1 0 0 1 1 1 0 NADH(P)-binding AlaDh_PNT_C PF01262.16 AIC15893.1 - 0.042 13.4 0.1 0.079 12.5 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain adh_short PF00106.20 AIC15893.1 - 0.06 13.2 1.4 0.27 11.1 0.0 2.6 4 0 0 4 4 4 0 short chain dehydrogenase 2-Hacid_dh_C PF02826.14 AIC15893.1 - 0.066 12.3 0.2 0.12 11.4 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.16 AIC15893.1 - 0.13 11.8 4.6 0.33 10.5 0.8 2.6 2 1 1 3 3 3 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Nitroreductase PF00881.19 AIC15894.1 - 1.4e-28 99.7 0.0 1.9e-28 99.3 0.0 1.2 1 0 0 1 1 1 1 Nitroreductase family Methyltransf_2 PF00891.13 AIC15895.1 - 2.5e-38 131.6 0.1 3.2e-38 131.3 0.1 1.0 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.1 AIC15895.1 - 2.5e-08 33.8 0.0 3.6e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15895.1 - 7.1e-07 28.9 0.0 1.1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC15895.1 - 2.4e-06 27.0 0.0 4.3e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.7 AIC15895.1 - 1.3e-05 25.5 0.3 2.8e-05 24.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15895.1 - 4.8e-05 23.8 0.0 8.6e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC15895.1 - 0.00015 21.8 0.0 0.00028 20.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.4 AIC15895.1 - 0.0051 16.2 0.0 0.0068 15.8 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase DUF938 PF06080.7 AIC15895.1 - 0.0067 15.9 0.0 0.017 14.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF938) Methyltransf_11 PF08241.7 AIC15895.1 - 0.015 15.7 0.1 0.035 14.5 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15895.1 - 0.038 14.3 0.0 0.11 12.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_9 PF08003.6 AIC15895.1 - 0.051 12.2 0.0 0.075 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PrmA PF06325.8 AIC15895.1 - 0.089 11.9 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.7 AIC15896.1 - 6.1e-13 49.0 0.0 9.6e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15896.1 - 2.8e-07 30.3 0.0 4.5e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.15 AIC15896.1 - 0.00026 20.1 0.0 0.00054 19.1 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.7 AIC15896.1 - 0.00057 20.3 0.0 0.0012 19.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC15896.1 - 0.0015 17.9 0.1 0.015 14.7 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.1 AIC15896.1 - 0.0095 16.2 0.0 0.02 15.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.10 AIC15896.1 - 0.023 14.3 0.0 0.035 13.7 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_31 PF13847.1 AIC15896.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain DUF4367 PF14285.1 AIC15897.1 - 0.097 11.9 0.4 0.12 11.6 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) Adeno_E3 PF06040.6 AIC15898.1 - 0.2 11.5 0.8 0.58 10.1 0.1 2.0 2 0 0 2 2 2 0 Adenovirus E3 protein DUF677 PF05055.7 AIC15898.1 - 0.23 10.0 3.6 0.97 8.0 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF677) HTH_AsnC-type PF13404.1 AIC15899.1 - 5.1e-16 57.9 0.8 1.2e-15 56.7 0.2 1.8 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.1 AIC15899.1 - 8e-15 53.9 0.8 1.6e-14 53.0 0.1 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.16 AIC15899.1 - 2.3e-11 43.2 0.3 3.7e-11 42.5 0.2 1.3 1 0 0 1 1 1 1 AsnC family HTH_11 PF08279.7 AIC15899.1 - 6.7e-05 22.4 0.2 0.00016 21.2 0.2 1.7 1 0 0 1 1 1 1 HTH domain HTH_5 PF01022.15 AIC15899.1 - 0.0001 21.8 0.0 0.00084 18.9 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_IclR PF09339.5 AIC15899.1 - 0.0008 18.9 0.0 0.0018 17.8 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.2 AIC15899.1 - 0.0013 18.3 0.2 0.0037 16.9 0.0 1.8 1 1 1 2 2 2 1 MarR family TrmB PF01978.14 AIC15899.1 - 0.0022 17.6 0.2 0.011 15.4 0.0 2.0 1 1 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_Tnp_ISL3 PF13542.1 AIC15899.1 - 0.0082 15.3 0.1 0.03 13.5 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 NapD PF03927.8 AIC15899.1 - 0.0099 15.6 2.5 0.061 13.1 0.5 2.2 2 0 0 2 2 2 1 NapD protein HTH_20 PF12840.2 AIC15899.1 - 0.024 14.4 0.0 0.066 13.0 0.0 1.8 2 1 0 2 2 2 0 Helix-turn-helix domain HTH_6 PF01418.12 AIC15899.1 - 0.031 14.0 0.2 0.031 14.0 0.1 2.4 2 1 1 3 3 2 0 Helix-turn-helix domain, rpiR family MarR PF01047.17 AIC15899.1 - 0.036 13.7 1.9 0.048 13.3 0.0 2.1 3 0 0 3 3 3 0 MarR family B-block_TFIIIC PF04182.7 AIC15899.1 - 0.048 13.5 0.0 0.15 11.9 0.0 1.9 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC FaeA PF04703.7 AIC15899.1 - 0.06 13.5 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 FaeA-like protein Sigma70_r4 PF04545.11 AIC15899.1 - 0.063 12.6 0.1 0.16 11.2 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 GYD PF08734.6 AIC15899.1 - 0.094 12.4 0.1 0.44 10.3 0.0 2.1 1 1 1 2 2 2 0 GYD domain Mga PF05043.8 AIC15899.1 - 0.095 12.9 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain Rrf2 PF02082.15 AIC15899.1 - 0.095 12.8 0.1 0.5 10.5 0.0 2.1 1 1 1 2 2 2 0 Transcriptional regulator HTH_12 PF08461.5 AIC15899.1 - 0.097 12.4 0.1 0.19 11.4 0.1 1.6 1 1 0 1 1 1 0 Ribonuclease R winged-helix domain HTH_34 PF13601.1 AIC15899.1 - 0.11 12.5 0.0 0.23 11.4 0.0 1.6 1 1 0 1 1 1 0 Winged helix DNA-binding domain HTH_DeoR PF08220.7 AIC15899.1 - 0.11 12.0 0.1 0.23 11.0 0.1 1.5 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_Mga PF08280.6 AIC15899.1 - 0.12 12.1 0.1 0.64 9.8 0.0 2.0 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain TAFII55_N PF04658.8 AIC15899.1 - 0.15 11.5 1.1 3.2 7.2 0.0 2.4 2 1 0 2 2 2 0 TAFII55 protein conserved region Aminotran_3 PF00202.16 AIC15900.1 - 1e-105 353.3 0.2 1.3e-105 353.0 0.1 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 AIC15900.1 - 0.0001 21.3 0.0 0.00035 19.6 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.14 AIC15900.1 - 0.0017 17.1 0.0 0.0024 16.6 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Microvir_J PF04726.8 AIC15900.1 - 0.12 12.3 0.1 0.24 11.3 0.1 1.5 1 0 0 1 1 1 0 Microvirus J protein AA_kinase PF00696.23 AIC15901.1 - 9.9e-34 116.9 5.1 1.1e-33 116.7 3.5 1.0 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dh PF01118.19 AIC15902.1 - 1.2e-37 128.8 0.0 2.4e-37 127.9 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.13 AIC15902.1 - 1.2e-22 80.6 0.0 1.8e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain F420_oxidored PF03807.12 AIC15902.1 - 8.9e-05 22.8 0.0 0.00021 21.6 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.15 AIC15902.1 - 0.00022 21.1 0.1 0.00047 20.0 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 AIC15902.1 - 0.002 18.6 0.0 0.0041 17.6 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_10 PF13460.1 AIC15902.1 - 0.0028 17.6 0.0 0.0057 16.6 0.0 1.5 1 0 0 1 1 1 1 NADH(P)-binding Ldh_1_N PF00056.18 AIC15902.1 - 0.076 12.8 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Saccharop_dh PF03435.13 AIC15902.1 - 0.1 11.5 0.0 0.13 11.2 0.0 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase RimK PF08443.6 AIC15903.1 - 2.4e-48 164.1 0.0 3.2e-48 163.7 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.11 AIC15903.1 - 3.2e-14 52.4 0.0 4.5e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_4 PF13535.1 AIC15903.1 - 6e-14 52.1 0.0 8.5e-14 51.6 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.9 AIC15903.1 - 2.2e-10 40.6 0.0 6.6e-10 39.0 0.0 1.7 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_Ter PF15632.1 AIC15903.1 - 5.3e-09 35.2 0.0 1.4e-08 33.8 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.17 AIC15903.1 - 4.1e-07 29.5 0.0 8.8e-07 28.4 0.0 1.4 1 1 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 AIC15903.1 - 3e-05 23.3 0.0 5.8e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_YheCD PF14398.1 AIC15903.1 - 0.00017 20.5 0.0 0.0034 16.2 0.0 2.2 1 1 1 2 2 2 1 YheC/D like ATP-grasp ATP-grasp_5 PF13549.1 AIC15903.1 - 0.0016 17.7 0.0 0.0038 16.4 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.8 AIC15903.1 - 0.04 13.2 0.0 0.19 11.0 0.0 1.9 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus ATP-grasp_2 PF08442.5 AIC15903.1 - 0.054 12.8 0.0 0.19 11.1 0.0 1.8 1 1 1 2 2 2 0 ATP-grasp domain GARS_A PF01071.14 AIC15903.1 - 0.067 12.7 0.0 0.24 10.9 0.0 1.8 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain zinc_ribbon_4 PF13717.1 AIC15904.1 - 6.4e-05 22.5 4.3 0.0017 18.0 0.9 2.1 1 1 1 2 2 2 2 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC15904.1 - 6.4e-05 22.4 1.4 0.0094 15.5 1.4 2.1 1 1 1 2 2 2 2 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC15904.1 - 0.00024 20.1 0.7 0.29 10.4 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain YhfH PF14149.1 AIC15904.1 - 0.0026 17.5 3.9 0.029 14.1 0.5 2.1 2 0 0 2 2 2 1 YhfH-like protein DNA_RNApol_7kD PF03604.8 AIC15904.1 - 0.003 16.9 4.1 0.057 12.8 2.5 2.6 1 1 2 3 3 3 1 DNA directed RNA polymerase, 7 kDa subunit zf-RING_3 PF14369.1 AIC15904.1 - 0.0033 17.3 0.9 0.0061 16.5 0.6 1.4 1 1 0 1 1 1 1 zinc-finger PAAR_motif PF05488.8 AIC15904.1 - 0.0075 16.2 0.2 0.0081 16.1 0.1 1.3 1 0 0 1 1 1 1 PAAR motif DZR PF12773.2 AIC15904.1 - 0.0096 15.7 0.8 0.014 15.1 0.6 1.4 1 1 0 1 1 1 1 Double zinc ribbon zf-C4_Topoisom PF01396.14 AIC15904.1 - 0.012 15.1 1.7 1.1 8.8 0.0 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger DUF1272 PF06906.6 AIC15904.1 - 0.012 15.4 4.1 1.3 8.9 0.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) OrfB_Zn_ribbon PF07282.6 AIC15904.1 - 0.012 15.2 0.2 0.017 14.7 0.1 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-IS66 PF13005.2 AIC15904.1 - 0.013 15.4 4.4 0.1 12.5 0.1 2.3 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 Prok-RING_1 PF14446.1 AIC15904.1 - 0.019 14.6 5.2 0.13 12.0 3.6 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.5 AIC15904.1 - 0.021 14.7 3.6 0.15 12.0 2.4 2.0 1 1 1 2 2 2 0 Zinc ribbon domain HypA PF01155.14 AIC15904.1 - 0.023 14.4 0.3 0.024 14.3 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family UPF0547 PF10571.4 AIC15904.1 - 0.024 14.3 1.1 3.1 7.5 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 PhnA_Zn_Ribbon PF08274.7 AIC15904.1 - 0.049 13.4 0.1 0.098 12.4 0.1 1.5 1 1 0 1 1 1 0 PhnA Zinc-Ribbon zf-CSL PF05207.8 AIC15904.1 - 0.057 12.9 1.8 0.24 10.9 1.2 1.8 1 1 1 2 2 2 0 CSL zinc finger zinc_ribbon_2 PF13240.1 AIC15904.1 - 0.065 12.7 2.8 0.53 9.8 1.9 2.1 1 1 0 1 1 1 0 zinc-ribbon domain A2L_zn_ribbon PF08792.5 AIC15904.1 - 0.078 12.4 2.1 2.7 7.5 0.0 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-HYPF PF07503.7 AIC15904.1 - 0.083 12.3 2.5 1.1 8.7 1.7 2.0 1 1 0 1 1 1 0 HypF finger CpXC PF14353.1 AIC15904.1 - 0.095 12.6 0.2 5.1 7.0 0.0 2.1 2 0 0 2 2 2 0 CpXC protein Nudix_N_2 PF14803.1 AIC15904.1 - 0.13 11.9 0.9 11 5.8 0.1 2.2 2 0 0 2 2 2 0 Nudix N-terminal Lar_restr_allev PF14354.1 AIC15904.1 - 0.15 12.4 3.5 1.5 9.1 0.1 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar DUF983 PF06170.7 AIC15904.1 - 0.16 12.1 1.1 7.1 6.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF983) TF_Zn_Ribbon PF08271.7 AIC15904.1 - 0.18 11.1 3.0 0.47 9.8 2.2 1.6 1 1 1 2 2 2 0 TFIIB zinc-binding DUF3797 PF12677.2 AIC15904.1 - 0.23 11.0 3.0 2.4 7.8 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) zf-trcl PF13451.1 AIC15904.1 - 0.69 9.5 2.8 4.4 7.0 0.1 2.1 2 0 0 2 2 2 0 Probable zinc-binding domain DUF164 PF02591.10 AIC15904.1 - 1.9 8.3 3.9 9.9 6.0 2.7 2.0 1 1 0 1 1 1 0 Putative zinc ribbon domain zf-dskA_traR PF01258.12 AIC15904.1 - 2.1 8.1 7.8 3.1 7.6 0.8 2.2 1 1 1 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-TFIIB PF13453.1 AIC15904.1 - 7.1 5.9 7.2 1.8 7.8 0.5 2.2 2 1 0 2 2 2 0 Transcription factor zinc-finger Arginosuc_synth PF00764.14 AIC15905.1 - 3.5e-161 536.5 0.2 4e-161 536.3 0.1 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.16 AIC15905.1 - 0.00052 19.5 0.0 0.00086 18.8 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.8 AIC15905.1 - 0.056 12.7 0.1 0.12 11.6 0.0 1.6 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 AIC15905.1 - 0.083 11.4 0.0 0.15 10.6 0.0 1.5 1 0 0 1 1 1 0 tRNA methyl transferase ACT_7 PF13840.1 AIC15906.1 - 4.5e-06 26.0 0.0 1.1e-05 24.8 0.0 1.7 1 0 0 1 1 1 1 ACT domain ECH_C PF13766.1 AIC15906.1 - 0.0083 16.2 0.2 0.04 14.0 0.1 2.1 1 1 1 2 2 2 1 2-enoyl-CoA Hydratase C-terminal region DUF1319 PF07028.6 AIC15906.1 - 0.033 14.3 0.4 0.066 13.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) Rep_fac_C PF08542.6 AIC15906.1 - 0.093 12.7 0.2 0.55 10.2 0.0 2.1 2 1 0 2 2 2 0 Replication factor C C-terminal domain PDZ_1 PF12812.2 AIC15906.1 - 0.12 12.3 0.2 0.28 11.0 0.1 1.7 1 1 0 1 1 1 0 PDZ-like domain HTH_11 PF08279.7 AIC15909.1 - 4.4e-07 29.4 0.1 7.6e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 HTH domain B12-binding_2 PF02607.12 AIC15909.1 - 9.8e-07 28.7 0.1 2.2e-06 27.6 0.1 1.6 1 0 0 1 1 1 1 B12 binding domain HTH_24 PF13412.1 AIC15909.1 - 4.5e-06 25.9 0.0 8.2e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF2250 PF10007.4 AIC15909.1 - 0.00039 20.2 0.1 0.00073 19.3 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) MarR PF01047.17 AIC15909.1 - 0.0024 17.5 0.1 0.0045 16.6 0.0 1.4 1 0 0 1 1 1 1 MarR family GntR PF00392.16 AIC15909.1 - 0.0083 15.5 0.0 0.018 14.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_5 PF01022.15 AIC15909.1 - 0.01 15.4 0.0 0.022 14.4 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family RepL PF05732.6 AIC15909.1 - 0.043 13.0 0.2 0.079 12.1 0.1 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) HTH_IclR PF09339.5 AIC15909.1 - 0.049 13.2 0.0 0.18 11.4 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain HTH_45 PF14947.1 AIC15909.1 - 0.1 12.4 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Yip1 PF04893.12 AIC15910.1 - 0.11 11.9 26.6 0.16 11.4 18.4 1.3 1 0 0 1 1 1 0 Yip1 domain FUN14 PF04930.10 AIC15911.1 - 2.7e-21 75.7 7.1 3.1e-21 75.5 4.9 1.0 1 0 0 1 1 1 1 FUN14 family DUF4097 PF13349.1 AIC15911.1 - 0.29 10.6 2.5 0.16 11.5 0.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4097) Vma12 PF11712.3 AIC15911.1 - 0.44 10.2 5.0 1.6 8.4 2.1 1.9 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase SPC12 PF06645.8 AIC15911.1 - 1.6 8.5 7.2 0.6 9.9 2.9 1.9 2 1 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) ATPase_gene1 PF09527.5 AIC15911.1 - 3.1 7.6 10.9 0.3 10.9 3.5 2.1 2 0 0 2 2 2 0 Putative F0F1-ATPase subunit (ATPase_gene1) RINT1_TIP1 PF04437.8 AIC15912.1 - 0.1 11.1 2.7 0.11 10.9 1.8 1.1 1 0 0 1 1 1 0 RINT-1 / TIP-1 family DUF3416 PF11896.3 AIC15912.1 - 0.17 11.8 2.6 0.22 11.4 1.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) DUF3665 PF12427.3 AIC15912.1 - 0.2 11.0 0.6 0.73 9.2 0.1 2.2 2 0 0 2 2 2 0 Branched-chain amino acid aminotransferase HXXSHH PF07586.6 AIC15912.1 - 0.28 10.0 1.8 0.35 9.7 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1552) NPV_P10 PF05531.7 AIC15912.1 - 0.49 10.6 2.4 0.64 10.3 0.4 2.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein V_ATPase_I PF01496.14 AIC15912.1 - 0.58 7.9 9.7 0.76 7.5 6.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlpD PF02662.11 AIC15912.1 - 0.6 9.8 2.4 15 5.3 0.4 2.3 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit DUF4446 PF14584.1 AIC15912.1 - 0.95 9.2 12.2 3.1 7.6 2.5 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) DUF848 PF05852.6 AIC15912.1 - 1.6 8.5 12.1 0.22 11.3 4.6 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) IncA PF04156.9 AIC15912.1 - 1.6 8.2 22.3 0.37 10.3 4.7 2.1 1 1 1 2 2 2 0 IncA protein Cauli_AT PF03233.8 AIC15912.1 - 3.7 7.2 15.1 1.2 8.8 4.4 2.6 1 1 2 3 3 3 0 Aphid transmission protein Atg14 PF10186.4 AIC15912.1 - 3.9 6.3 19.4 9 5.1 12.6 2.1 1 1 1 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 PEARLI-4 PF05278.7 AIC15912.1 - 10 5.4 20.5 4.6 6.5 6.6 2.3 2 1 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Methyltransf_11 PF08241.7 AIC15913.1 - 5.6e-21 74.8 0.0 1.2e-20 73.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC15913.1 - 2.9e-20 72.4 0.0 3.3e-20 72.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15913.1 - 5.2e-15 55.9 0.0 1.1e-14 54.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15913.1 - 7.3e-14 51.7 0.0 9.2e-14 51.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15913.1 - 1.5e-11 44.6 0.0 2.5e-11 43.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC15913.1 - 1.6e-11 44.4 0.0 4.6e-11 42.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC15913.1 - 3.1e-09 36.2 0.0 4.3e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_26 PF13659.1 AIC15913.1 - 2e-08 34.2 0.2 1.2e-07 31.7 0.1 2.3 2 1 0 2 2 2 1 Methyltransferase domain MTS PF05175.9 AIC15913.1 - 1.5e-05 24.4 0.0 2.3e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 AIC15913.1 - 0.00026 20.5 0.0 0.00036 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_4 PF02390.12 AIC15913.1 - 0.0029 16.6 0.0 0.0043 16.1 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_32 PF13679.1 AIC15913.1 - 0.0036 16.9 0.0 0.0056 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.9 AIC15913.1 - 0.005 16.0 0.0 0.0078 15.3 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB PrmA PF06325.8 AIC15913.1 - 0.0098 15.0 0.0 0.015 14.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.7 AIC15913.1 - 0.0099 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.15 AIC15913.1 - 0.04 12.9 0.0 0.064 12.3 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_2 PF00891.13 AIC15913.1 - 0.074 12.2 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 O-methyltransferase Polyketide_cyc2 PF10604.4 AIC15914.1 - 0.04 14.0 0.0 0.043 13.9 0.0 1.0 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport MHCassoc_trimer PF08831.5 AIC15914.1 - 0.084 12.7 0.0 0.084 12.7 0.0 1.1 1 0 0 1 1 1 0 Class II MHC-associated invariant chain trimerisation domain eIF-1a PF01176.14 AIC15915.1 - 1e-21 76.1 1.0 1.2e-21 75.8 0.7 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.14 AIC15915.1 - 0.0057 16.3 1.1 0.023 14.3 0.2 2.1 2 1 0 2 2 2 1 Myosin N-terminal SH3-like domain DUF1314 PF07013.6 AIC15915.1 - 0.066 12.6 0.0 0.086 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) Ribosomal_60s PF00428.14 AIC15916.1 - 2.4e-17 63.0 14.0 2.9e-17 62.8 9.7 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein DUF348 PF03990.9 AIC15916.1 - 0.12 11.9 1.0 0.69 9.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF348) PepSY_2 PF13670.1 AIC15916.1 - 0.14 12.0 3.8 3.3 7.6 1.8 2.2 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain zinc_ribbon_5 PF13719.1 AIC15918.1 - 0.12 11.9 2.5 0.81 9.3 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain CpXC PF14353.1 AIC15918.1 - 0.14 12.0 0.6 2.2 8.2 0.0 2.3 1 1 1 2 2 2 0 CpXC protein zinc_ribbon_4 PF13717.1 AIC15918.1 - 0.17 11.5 2.6 1 9.1 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.2 AIC15918.1 - 3 7.7 5.6 3.9 7.3 2.7 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Ribosomal_L10 PF00466.15 AIC15919.1 - 1.3e-19 69.9 1.7 3.4e-19 68.6 0.9 1.8 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_L1 PF00687.16 AIC15920.1 - 5.1e-40 137.1 0.0 6.6e-40 136.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Polysacc_deac_1 PF01522.16 AIC15921.1 - 1.8e-11 43.7 0.0 3.3e-11 42.8 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 AIC15921.1 - 0.036 12.9 0.0 0.046 12.6 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Glycos_transf_2 PF00535.21 AIC15922.1 - 4.1e-11 42.8 0.0 4.2e-10 39.5 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AIC15922.1 - 5.9e-05 22.9 0.0 9.1e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Metallophos_2 PF12850.2 AIC15922.1 - 0.1 12.4 0.0 0.56 10.0 0.0 2.1 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase superfamily domain Hexapep PF00132.19 AIC15923.1 - 2.3e-30 102.7 23.1 1.9e-11 42.9 4.6 4.1 4 0 0 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 AIC15923.1 - 1.9e-14 52.9 23.1 2.2e-07 30.3 0.3 4.3 3 1 1 4 4 4 3 Hexapeptide repeat of succinyl-transferase Polysacc_deac_1 PF01522.16 AIC15924.1 - 0.085 12.4 0.1 0.13 11.9 0.1 1.5 1 1 0 1 1 1 0 Polysaccharide deacetylase Baculo_PEP_C PF04513.7 AIC15926.1 - 0.0017 18.2 2.1 0.0027 17.5 1.4 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus TBPIP PF07106.8 AIC15926.1 - 0.0034 16.9 0.4 0.0066 16.0 0.2 1.5 2 0 0 2 2 2 1 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) YtkA PF13115.1 AIC15926.1 - 0.0074 16.6 0.0 0.027 14.8 0.0 2.0 2 0 0 2 2 2 1 YtkA-like Filament PF00038.16 AIC15926.1 - 0.014 14.8 0.1 0.019 14.4 0.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein Cob_adeno_trans PF01923.13 AIC15926.1 - 0.023 14.4 0.2 0.038 13.7 0.1 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase PurA PF04845.8 AIC15926.1 - 0.032 13.3 0.2 0.053 12.6 0.1 1.3 1 0 0 1 1 1 0 PurA ssDNA and RNA-binding protein Laminin_II PF06009.7 AIC15926.1 - 0.042 13.6 0.8 0.071 12.8 0.6 1.3 1 0 0 1 1 1 0 Laminin Domain II Spc7 PF08317.6 AIC15926.1 - 0.1 11.2 0.2 0.19 10.3 0.1 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein LPP PF04728.8 AIC15926.1 - 0.11 12.2 0.8 0.31 10.8 0.3 1.9 1 1 1 2 2 2 0 Lipoprotein leucine-zipper A2M_N PF01835.14 AIC15926.1 - 0.13 12.5 0.0 0.38 11.0 0.0 1.8 2 0 0 2 2 2 0 MG2 domain FlgD_ig PF13860.1 AIC15926.1 - 0.13 11.9 0.0 0.44 10.3 0.0 1.9 1 0 0 1 1 1 0 FlgD Ig-like domain DUF432 PF04254.8 AIC15926.1 - 0.14 12.0 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF432) DUF1664 PF07889.7 AIC15926.1 - 0.2 11.4 0.8 0.38 10.5 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) H-kinase_dim PF02895.9 AIC15926.1 - 0.2 12.0 1.6 0.48 10.7 0.6 1.9 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain DUF4519 PF15012.1 AIC15926.1 - 0.28 11.1 0.1 0.28 11.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Syntaxin-6_N PF09177.6 AIC15926.1 - 0.33 11.3 1.8 0.59 10.5 1.2 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Toxin_42 PF15522.1 AIC15930.1 - 0.078 12.1 0.1 2.5 7.2 0.0 2.1 2 0 0 2 2 2 0 Putative toxin 42 DUF2136 PF09907.4 AIC15931.1 - 0.00011 22.2 0.0 0.00012 22.0 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2136) Plasmid_stabil PF05016.9 AIC15931.1 - 0.056 13.8 0.1 0.065 13.6 0.1 1.2 1 0 0 1 1 1 0 Plasmid stabilisation system protein SMC_N PF02463.14 AIC15933.1 - 1.4e-24 86.5 0.0 1.8e-11 43.7 0.0 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.1 AIC15933.1 - 1.2e-17 64.9 15.5 3.6e-16 60.1 10.8 2.8 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 AIC15933.1 - 9.2e-14 51.2 0.0 6.2e-08 32.1 0.0 2.6 3 0 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.1 AIC15933.1 - 2.9e-12 47.1 0.0 1.4e-06 28.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_13 PF13166.1 AIC15933.1 - 3e-10 39.2 16.1 8.2e-06 24.5 9.2 4.0 2 1 0 2 2 2 2 AAA domain SbcCD_C PF13558.1 AIC15933.1 - 7.2e-10 38.6 0.0 2e-09 37.2 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.1 AIC15933.1 - 1.1e-07 31.2 0.0 2.4e-07 30.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.22 AIC15933.1 - 2.1e-05 24.8 5.4 0.024 14.9 0.2 3.6 4 1 0 4 4 4 2 ABC transporter AAA_10 PF12846.2 AIC15933.1 - 0.0052 16.2 0.4 0.0052 16.2 0.3 2.8 3 1 0 3 3 3 1 AAA-like domain DUF258 PF03193.11 AIC15933.1 - 0.013 14.7 0.0 0.025 13.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_33 PF13671.1 AIC15933.1 - 0.018 14.9 0.8 0.1 12.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain DNA_ligase_ZBD PF03119.11 AIC15933.1 - 0.027 14.1 0.0 0.082 12.6 0.0 1.9 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain GTP_EFTU PF00009.22 AIC15933.1 - 0.069 12.5 0.2 0.86 9.0 0.0 2.5 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain zf-C3HC4_3 PF13920.1 AIC15933.1 - 0.12 12.1 0.1 0.19 11.4 0.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) AAA_16 PF13191.1 AIC15933.1 - 0.29 11.0 10.3 0.38 10.6 0.0 3.4 3 0 0 3 3 3 0 AAA ATPase domain Dynamin_N PF00350.18 AIC15933.1 - 0.69 9.7 5.0 2 8.1 0.0 3.1 3 1 0 3 3 3 0 Dynamin family CENP-F_leu_zip PF10473.4 AIC15933.1 - 1.3 8.8 24.3 24 4.7 12.0 3.7 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-C4H2 PF10146.4 AIC15933.1 - 5.8 6.8 12.6 2.8 7.8 6.2 2.1 2 0 0 2 2 2 0 Zinc finger-containing protein ERM PF00769.14 AIC15933.1 - 7.4 6.0 35.6 1.1 8.7 3.8 2.7 2 1 0 2 2 2 0 Ezrin/radixin/moesin family Metallophos_2 PF12850.2 AIC15934.1 - 8.9e-15 54.8 0.1 1.5e-14 54.1 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 AIC15934.1 - 1.4e-12 47.4 0.2 2.1e-12 46.8 0.1 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Plasmid_stabil PF05016.9 AIC15935.1 - 8.9e-10 38.8 0.2 1e-09 38.6 0.2 1.0 1 0 0 1 1 1 1 Plasmid stabilisation system protein Gp49 PF05973.9 AIC15935.1 - 0.033 14.2 0.1 0.04 13.9 0.1 1.2 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) DUF217 PF02697.9 AIC15936.1 - 0.048 13.9 4.3 0.091 13.0 3.0 1.6 1 1 0 1 1 1 0 Uncharacterized ACR, COG1753 ISG65-75 PF11727.3 AIC15936.1 - 0.088 11.8 0.6 0.1 11.6 0.4 1.0 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF87 PF01935.12 AIC15938.1 - 2.8e-36 125.4 0.2 5.9e-36 124.4 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF87 AAA_10 PF12846.2 AIC15938.1 - 3.4e-17 62.8 1.0 8.1e-15 55.0 0.7 2.1 1 1 0 1 1 1 1 AAA-like domain DUF853 PF05872.7 AIC15938.1 - 2.4e-05 22.8 0.1 0.022 13.1 0.0 2.2 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF853) HAS-barrel PF09378.5 AIC15938.1 - 0.0048 16.7 0.1 0.013 15.3 0.1 1.8 1 0 0 1 1 1 1 HAS barrel domain Zot PF05707.7 AIC15938.1 - 0.005 16.3 0.0 0.01 15.3 0.0 1.4 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) TrwB_AAD_bind PF10412.4 AIC15938.1 - 0.005 15.5 0.1 0.017 13.7 0.0 1.8 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_16 PF13191.1 AIC15938.1 - 0.0073 16.3 0.2 0.16 11.9 0.1 2.6 1 1 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.13 AIC15938.1 - 0.014 14.9 3.4 2 7.8 0.1 2.9 3 0 0 3 3 3 0 FtsK/SpoIIIE family BATS PF06968.8 AIC15938.1 - 0.051 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Biotin and Thiamin Synthesis associated domain ABC_tran PF00005.22 AIC15938.1 - 0.14 12.4 0.0 0.4 10.9 0.0 1.7 1 1 0 1 1 1 0 ABC transporter NurA PF09376.5 AIC15939.1 - 2.8e-12 46.6 0.0 3.9e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 NurA domain SH3_5 PF08460.5 AIC15939.1 - 0.13 12.1 0.0 0.35 10.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial SH3 domain DAO PF01266.19 AIC15940.1 - 2.2e-41 141.9 0.1 3.4e-41 141.3 0.0 1.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.10 AIC15940.1 - 2.6e-07 29.2 0.0 1e-05 23.9 0.0 2.2 2 1 0 2 2 2 1 Malate:quinone oxidoreductase (Mqo) Pyr_redox_2 PF07992.9 AIC15940.1 - 0.00086 19.2 0.0 0.035 13.9 0.0 2.2 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.7 AIC15940.1 - 0.0023 16.8 0.2 1.7 7.4 0.0 2.4 2 0 0 2 2 2 2 Lycopene cyclase protein NAD_binding_8 PF13450.1 AIC15940.1 - 0.0024 17.8 0.0 0.008 16.1 0.0 1.9 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.1 AIC15940.1 - 0.0063 16.5 0.0 0.34 10.9 0.0 2.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 AIC15940.1 - 0.052 12.0 0.1 0.14 10.5 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.22 AIC15940.1 - 0.057 13.8 0.0 1.4 9.3 0.1 2.5 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.1 AIC15940.1 - 0.072 12.8 0.1 4.6 7.0 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding DNA_pol_B PF00136.16 AIC15941.1 - 1.7e-81 274.4 0.7 3.5e-81 273.3 0.1 1.7 2 0 0 2 2 2 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.14 AIC15941.1 - 4.2e-35 121.1 0.1 7.7e-35 120.2 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.4 AIC15941.1 - 0.0002 20.9 0.0 0.00057 19.4 0.0 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.1 AIC15941.1 - 0.0019 18.0 0.0 0.0078 16.0 0.0 2.1 2 0 0 2 2 2 1 RNase_H superfamily DNA_pol_B_2 PF03175.8 AIC15941.1 - 0.0063 15.2 0.0 0.018 13.6 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase type B, organellar and viral Vinculin PF01044.14 AIC15941.1 - 0.14 10.1 0.0 0.21 9.5 0.0 1.1 1 0 0 1 1 1 0 Vinculin family Arginase PF00491.16 AIC15942.1 - 1.8e-54 184.9 0.0 2.1e-54 184.6 0.0 1.0 1 0 0 1 1 1 1 Arginase family DUF2136 PF09907.4 AIC15943.1 - 0.033 14.2 0.3 0.05 13.6 0.2 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2136) Plasmid_Txe PF06769.8 AIC15943.1 - 0.085 12.6 0.3 0.11 12.2 0.2 1.2 1 0 0 1 1 1 0 Plasmid encoded toxin Txe DUF104 PF01954.11 AIC15943.1 - 0.093 12.7 0.3 0.22 11.5 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF104 DUF1021 PF06257.6 AIC15943.1 - 0.13 12.0 0.4 0.24 11.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1021) DUF3895 PF13034.1 AIC15944.1 - 0.065 12.7 0.1 0.32 10.4 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3895) tRNA-Thr_ED PF08915.6 AIC15945.1 - 1.2e-45 154.8 0.9 2.7e-45 153.7 0.6 1.6 1 0 0 1 1 1 1 Archaea-specific editing domain of threonyl-tRNA synthetase HGTP_anticodon PF03129.15 AIC15945.1 - 6.1e-25 86.9 2.3 1.4e-24 85.8 1.6 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.20 AIC15945.1 - 7e-25 87.5 1.8 1.4e-24 86.5 1.3 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) FAM177 PF14774.1 AIC15946.1 - 0.02 14.7 0.1 0.023 14.6 0.1 1.1 1 0 0 1 1 1 0 FAM177 family Ca_chan_IQ PF08763.6 AIC15946.1 - 0.073 12.3 0.1 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Voltage gated calcium channel IQ domain THAP PF05485.7 AIC15946.1 - 0.53 10.4 5.2 3 8.0 0.5 2.1 1 1 1 2 2 2 0 THAP domain DUF4293 PF14126.1 AIC15950.1 - 0.12 12.3 0.1 0.2 11.5 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) SSP160 PF06933.6 AIC15952.1 - 0.0018 16.3 8.3 0.0023 16.0 5.7 1.4 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 Collagen PF01391.13 AIC15952.1 - 0.89 9.1 6.0 2 8.0 4.1 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) TM_helix PF05552.7 AIC15953.1 - 1.1e-14 53.8 7.8 7.6e-11 41.5 0.6 3.7 4 0 0 4 4 4 2 Conserved TM helix MS_channel PF00924.13 AIC15953.1 - 1.8e-10 40.5 3.1 1.8e-10 40.5 2.2 1.8 2 0 0 2 2 2 1 Mechanosensitive ion channel Colicin_V PF02674.11 AIC15953.1 - 0.01 15.6 22.6 0.13 12.0 0.2 3.2 2 1 1 3 3 3 0 Colicin V production protein FtsX PF02687.16 AIC15953.1 - 1.6 8.5 25.2 3.8 7.2 2.6 3.4 1 1 2 3 3 3 0 FtsX-like permease family zf-DHHC PF01529.15 AIC15955.1 - 0.00023 20.5 0.6 0.00027 20.3 0.4 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase DZR PF12773.2 AIC15955.1 - 0.00051 19.7 0.7 0.00065 19.4 0.5 1.2 1 0 0 1 1 1 1 Double zinc ribbon zf-C3HC4_3 PF13920.1 AIC15955.1 - 0.00057 19.5 0.9 0.00069 19.2 0.6 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Cys_rich_KTR PF14205.1 AIC15955.1 - 0.0023 17.3 0.7 0.014 14.8 0.1 2.0 2 0 0 2 2 2 1 Cysteine-rich KTR Nudix_N_2 PF14803.1 AIC15955.1 - 0.0046 16.6 1.6 0.33 10.6 0.1 2.1 2 0 0 2 2 2 1 Nudix N-terminal DUF1272 PF06906.6 AIC15955.1 - 0.012 15.4 0.8 0.014 15.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-NADH-PPase PF09297.6 AIC15955.1 - 0.016 14.6 2.1 2.5 7.6 0.1 2.1 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain Cript PF10235.4 AIC15955.1 - 0.018 15.3 0.4 0.02 15.2 0.3 1.1 1 0 0 1 1 1 0 Microtubule-associated protein CRIPT zf-RING_5 PF14634.1 AIC15955.1 - 0.018 14.7 0.7 0.024 14.3 0.5 1.2 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_2 PF13923.1 AIC15955.1 - 0.029 14.3 1.2 0.041 13.9 0.8 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_2 PF13240.1 AIC15955.1 - 0.1 12.1 4.5 2 7.9 3.3 2.0 1 1 1 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC15955.1 - 0.17 11.1 4.6 0.25 10.5 0.2 1.8 1 1 1 2 2 2 0 zinc-ribbon domain zf-FPG_IleRS PF06827.9 AIC15955.1 - 0.18 11.4 3.8 4.6 6.9 0.2 2.1 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS Lar_restr_allev PF14354.1 AIC15955.1 - 0.18 12.0 2.0 2.4 8.5 0.1 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar Zn_ribbon_recom PF13408.1 AIC15955.1 - 0.2 11.9 2.6 0.24 11.7 0.3 1.9 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Prim_Zn_Ribbon PF08273.7 AIC15955.1 - 0.23 11.5 5.2 0.57 10.2 0.2 2.1 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase zf-C2HC_2 PF13913.1 AIC15955.1 - 1.7 8.3 4.5 0.53 10.0 0.6 2.1 2 1 0 2 2 2 0 zinc-finger of a C2HC-type RRN7 PF11781.3 AIC15955.1 - 2.8 7.5 5.0 13 5.3 0.2 2.1 1 1 1 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 Auto_anti-p27 PF06677.7 AIC15955.1 - 5.5 6.8 5.9 36 4.2 4.1 2.0 1 1 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) SNase PF00565.12 AIC15956.1 - 0.1 12.8 0.0 0.12 12.6 0.0 1.1 1 0 0 1 1 1 0 Staphylococcal nuclease homologue HTH_45 PF14947.1 AIC15959.1 - 1.6e-12 47.0 0.0 3.5e-12 45.9 0.0 1.5 1 1 0 1 1 1 1 Winged helix-turn-helix Mrr_N PF14338.1 AIC15959.1 - 0.0032 17.4 0.0 0.0036 17.3 0.0 1.3 1 0 0 1 1 1 1 Mrr N-terminal domain Cdc6_C PF09079.6 AIC15959.1 - 0.037 13.7 0.0 0.062 13.0 0.0 1.4 1 1 0 1 1 1 0 CDC6, C terminal HTH_27 PF13463.1 AIC15959.1 - 0.042 14.1 0.0 0.049 13.9 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain ABA_GPCR PF12430.3 AIC15960.1 - 0.0095 15.0 0.2 0.014 14.5 0.1 1.3 1 0 0 1 1 1 1 Abscisic acid G-protein coupled receptor DUF2837 PF10997.3 AIC15960.1 - 0.31 10.1 6.1 0.3 10.1 1.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2837) zinc_ribbon_4 PF13717.1 AIC15961.1 - 0.00043 19.9 5.1 0.0054 16.4 3.6 2.0 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC15961.1 - 0.0005 19.5 5.4 0.0052 16.3 3.8 2.0 1 1 0 1 1 1 1 zinc-ribbon domain IBR PF01485.16 AIC15961.1 - 0.004 16.9 1.2 0.0061 16.4 0.8 1.3 1 0 0 1 1 1 1 IBR domain zinc_ribbon_6 PF14599.1 AIC15961.1 - 0.0051 16.5 0.9 0.0066 16.2 0.6 1.2 1 0 0 1 1 1 1 Zinc-ribbon Ribosomal_S27e PF01667.12 AIC15961.1 - 0.0077 15.7 3.9 0.023 14.2 2.7 1.7 1 1 0 1 1 1 1 Ribosomal protein S27 Lar_restr_allev PF14354.1 AIC15961.1 - 0.052 13.8 3.3 1 9.6 0.2 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar DUF2387 PF09526.5 AIC15961.1 - 0.064 13.1 2.4 0.12 12.3 1.7 1.5 1 1 0 1 1 1 0 Probable metal-binding protein (DUF2387) HypA PF01155.14 AIC15961.1 - 0.065 12.9 0.3 0.07 12.8 0.2 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zinc-ribbons_6 PF07191.7 AIC15961.1 - 0.071 12.9 0.5 0.088 12.6 0.3 1.2 1 0 0 1 1 1 0 zinc-ribbons zf-DNL PF05180.7 AIC15961.1 - 0.11 12.2 2.1 0.78 9.4 1.5 1.9 1 1 1 2 2 2 0 DNL zinc finger DUF329 PF03884.9 AIC15961.1 - 0.17 11.4 2.5 0.72 9.4 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF329) zf-LSD1 PF06943.7 AIC15961.1 - 0.19 11.3 0.6 11 5.6 0.1 2.2 2 0 0 2 2 2 0 LSD1 zinc finger zf-ribbon_3 PF13248.1 AIC15961.1 - 0.2 10.9 3.4 0.58 9.4 2.0 2.0 2 1 1 3 3 3 0 zinc-ribbon domain PhnA_Zn_Ribbon PF08274.7 AIC15961.1 - 0.25 11.1 4.6 1.7 8.4 0.1 2.2 1 1 1 2 2 2 0 PhnA Zinc-Ribbon Mu-like_Com PF10122.4 AIC15961.1 - 0.99 8.5 3.2 4.3 6.4 2.2 1.9 1 1 0 1 1 1 0 Mu-like prophage protein Com TFIIS_C PF01096.13 AIC15961.1 - 3.2 7.4 5.4 4.4 7.0 0.5 2.1 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DZR PF12773.2 AIC15962.1 - 0.022 14.5 1.3 0.032 14.0 0.9 1.2 1 0 0 1 1 1 0 Double zinc ribbon Laminin_EGF PF00053.19 AIC15962.1 - 0.024 14.5 1.3 0.032 14.1 0.9 1.2 1 0 0 1 1 1 0 Laminin EGF-like (Domains III and V) ABC_membrane_3 PF13748.1 AIC15962.1 - 0.12 11.4 0.7 0.15 11.0 0.5 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region zf-ribbon_3 PF13248.1 AIC15962.1 - 0.12 11.5 3.5 0.49 9.6 2.4 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 AIC15962.1 - 0.23 11.0 2.1 11 5.6 0.0 2.2 1 1 1 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 AIC15962.1 - 0.58 10.1 2.7 17 5.4 1.8 2.2 1 1 0 1 1 1 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.8 AIC15962.1 - 0.84 9.1 3.2 6.4 6.3 2.2 2.0 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Iron_traffic PF04362.9 AIC15963.1 - 1.6e-08 33.8 0.0 2.1e-08 33.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial Fe(2+) trafficking zinc_ribbon_2 PF13240.1 AIC15963.1 - 0.096 12.2 0.4 0.2 11.1 0.3 1.5 1 0 0 1 1 1 0 zinc-ribbon domain YhfH PF14149.1 AIC15963.1 - 0.21 11.3 0.3 0.21 11.3 0.2 1.8 2 0 0 2 2 2 0 YhfH-like protein zf-ribbon_3 PF13248.1 AIC15963.1 - 2.4 7.4 4.7 5.5 6.3 3.3 1.7 1 1 0 1 1 1 0 zinc-ribbon domain Adenylsucc_synt PF00709.16 AIC15965.1 - 2.1e-85 286.9 0.3 3.4e-41 141.2 0.0 3.0 1 1 2 3 3 3 3 Adenylosuccinate synthetase OMPdecase PF00215.19 AIC15968.1 - 3.4e-31 108.3 0.9 4.2e-31 108.1 0.6 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family PcrB PF01884.12 AIC15968.1 - 0.032 13.4 0.6 0.26 10.4 0.1 2.3 2 1 1 3 3 3 0 PcrB family NUDIX PF00293.23 AIC15969.1 - 2.8e-17 62.6 0.1 3.4e-17 62.3 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.1 AIC15969.1 - 0.11 11.9 0.0 0.21 11.0 0.0 1.4 1 0 0 1 1 1 0 NUDIX domain Adeno_E4 PF05385.6 AIC15969.1 - 0.13 12.2 0.1 0.2 11.6 0.1 1.4 1 1 0 1 1 1 0 Mastadenovirus early E4 13 kDa protein Ribosomal_60s PF00428.14 AIC15970.1 - 0.86 10.0 8.8 0.98 9.8 6.1 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein NUT_C PF12882.2 AIC15970.1 - 4.8 6.7 6.6 5.1 6.6 4.3 1.3 1 1 0 1 1 1 0 NUT protein C terminal DUF373 PF04123.8 AIC15971.1 - 2.1e-99 332.8 9.7 2.5e-99 332.5 6.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF373) DUF202 PF02656.10 AIC15971.1 - 3.4 7.9 9.6 6.5 7.0 0.5 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF202) TctB PF07331.6 AIC15971.1 - 5.8 6.5 16.7 1.4 8.5 0.8 2.9 1 1 2 3 3 3 0 Tripartite tricarboxylate transporter TctB family FtsJ PF01728.14 AIC15972.1 - 4e-58 196.3 0.0 4.5e-58 196.2 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.1 AIC15972.1 - 1.1e-07 31.6 0.0 1.9e-06 27.5 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC15972.1 - 2.4e-07 30.5 0.0 1e-06 28.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC15972.1 - 0.00017 22.1 0.3 0.0021 18.5 0.2 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC15972.1 - 0.00067 19.6 0.1 0.0024 17.9 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC15972.1 - 0.0023 18.3 0.3 0.02 15.4 0.1 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC15972.1 - 0.023 15.1 0.0 0.15 12.5 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.13 AIC15972.1 - 0.04 13.0 0.1 0.18 10.8 0.0 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.1 AIC15972.1 - 0.093 13.0 0.0 0.43 10.9 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain NSP13 PF06460.7 AIC15972.1 - 0.095 11.5 0.0 0.15 10.9 0.0 1.2 1 0 0 1 1 1 0 Coronavirus NSP13 CMAS PF02353.15 AIC15972.1 - 0.16 11.0 0.0 0.24 10.4 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase RNA_pol_Rpc34 PF05158.7 AIC15973.1 - 6.2e-06 25.6 0.6 0.00015 21.0 0.2 2.2 1 1 1 2 2 2 1 RNA polymerase Rpc34 subunit MarR PF01047.17 AIC15973.1 - 0.014 15.1 0.1 0.025 14.2 0.1 1.4 1 0 0 1 1 1 0 MarR family B-block_TFIIIC PF04182.7 AIC15973.1 - 0.044 13.6 0.0 0.057 13.2 0.0 1.4 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC MarR_2 PF12802.2 AIC15973.1 - 0.045 13.4 0.2 0.069 12.8 0.1 1.3 1 0 0 1 1 1 0 MarR family Glyoxalase_2 PF12681.2 AIC15974.1 - 1.3e-13 51.4 0.0 1.6e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 AIC15974.1 - 1.1e-05 25.3 0.0 0.00015 21.7 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HpaB_N PF11794.3 AIC15975.1 - 3.6e-89 298.6 0.0 5.3e-89 298.0 0.0 1.3 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HpaB PF03241.8 AIC15975.1 - 4.1e-74 247.8 0.2 5.5e-74 247.4 0.1 1.2 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase C terminal Abhydrolase_6 PF12697.2 AIC15976.1 - 3.8e-33 115.2 0.0 5.2e-33 114.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AIC15976.1 - 5.3e-19 68.4 0.0 1e-18 67.4 0.0 1.4 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AIC15976.1 - 4.7e-16 59.0 0.2 1.5e-14 54.1 0.1 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.3 AIC15976.1 - 8.5e-07 28.7 0.0 1.5e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Putative lysophospholipase Thioesterase PF00975.15 AIC15976.1 - 1.3e-05 25.5 0.0 1.7e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain DUF1057 PF06342.7 AIC15976.1 - 1.4e-05 24.0 0.0 3.1e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Abhydrolase_2 PF02230.11 AIC15976.1 - 7.4e-05 22.2 0.8 0.49 9.7 0.0 3.6 3 1 1 4 4 4 1 Phospholipase/Carboxylesterase DUF676 PF05057.9 AIC15976.1 - 0.00022 20.5 0.0 0.00064 19.0 0.0 1.8 2 1 0 2 2 2 1 Putative serine esterase (DUF676) UPF0227 PF05728.7 AIC15976.1 - 0.00044 20.0 0.2 0.0018 18.0 0.1 2.1 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0227) Chlorophyllase2 PF12740.2 AIC15976.1 - 0.0011 17.9 0.0 0.0016 17.3 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Peptidase_S9 PF00326.16 AIC15976.1 - 0.0037 16.5 0.0 0.03 13.5 0.0 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family PGAP1 PF07819.8 AIC15976.1 - 0.006 16.1 0.5 0.051 13.1 0.3 2.3 1 1 0 1 1 1 1 PGAP1-like protein DUF2305 PF10230.4 AIC15976.1 - 0.0067 15.8 0.0 0.0085 15.5 0.0 1.3 1 0 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) Abhydro_lipase PF04083.11 AIC15976.1 - 0.0083 15.4 0.2 0.026 13.8 0.1 1.7 2 0 0 2 2 2 1 Partial alpha/beta-hydrolase lipase region Ndr PF03096.9 AIC15976.1 - 0.012 14.1 0.0 0.022 13.2 0.0 1.5 1 1 0 1 1 1 0 Ndr family FSH1 PF03959.8 AIC15976.1 - 0.016 14.6 0.1 0.32 10.4 0.0 2.6 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.8 AIC15976.1 - 0.017 14.6 0.0 0.027 14.0 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Ser_hydrolase PF06821.8 AIC15976.1 - 0.018 14.6 0.0 0.049 13.2 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase Esterase PF00756.15 AIC15976.1 - 0.022 14.1 0.0 0.035 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Lipase_3 PF01764.20 AIC15976.1 - 0.027 14.0 0.0 0.13 11.8 0.0 1.9 2 0 0 2 2 2 0 Lipase (class 3) Chlorophyllase PF07224.6 AIC15976.1 - 0.043 12.5 0.0 0.058 12.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase DLH PF01738.13 AIC15976.1 - 0.079 12.2 0.0 5.6 6.1 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_8 PF06259.7 AIC15976.1 - 0.11 11.9 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Peptidase_M10 PF00413.19 AIC15977.1 - 0.03 14.0 0.0 0.039 13.6 0.0 1.3 1 0 0 1 1 1 0 Matrixin OrfB_Zn_ribbon PF07282.6 AIC15978.1 - 5e-20 70.9 0.3 8.8e-20 70.1 0.2 1.4 1 0 0 1 1 1 1 Putative transposase DNA-binding domain OrfB_IS605 PF01385.14 AIC15978.1 - 0.00093 18.6 2.4 0.0019 17.6 1.7 1.4 1 0 0 1 1 1 1 Probable transposase DZR PF12773.2 AIC15978.1 - 0.018 14.8 0.5 0.039 13.7 0.4 1.5 1 0 0 1 1 1 0 Double zinc ribbon RTC4 PF14474.1 AIC15978.1 - 0.075 12.9 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 RTC4-like domain zf-CCHC_5 PF14787.1 AIC15978.1 - 0.079 12.4 1.2 0.18 11.2 0.8 1.6 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger DUF3252 PF11623.3 AIC15978.1 - 0.082 12.3 0.0 0.46 9.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3252) Zn_Tnp_IS1595 PF12760.2 AIC15978.1 - 0.09 12.6 3.9 0.21 11.4 2.7 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Integrase_AP2 PF14657.1 AIC15979.1 - 0.097 12.4 0.3 1.9 8.3 0.3 2.2 2 0 0 2 2 2 0 AP2-like DNA-binding integrase domain Pribosyltran PF00156.22 AIC15980.1 - 4.7e-17 61.8 0.3 6.7e-17 61.3 0.2 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.1 AIC15980.1 - 2e-05 23.8 0.0 2.6e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PNP_UDP_1 PF01048.15 AIC15981.1 - 9.4e-44 149.1 0.0 1.1e-43 148.9 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily TrmB PF01978.14 AIC15984.1 - 8.3e-11 41.4 0.1 1.1e-10 41.0 0.1 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Ferritin PF00210.19 AIC15985.1 - 6.4e-21 74.6 0.1 7.5e-21 74.3 0.1 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.12 AIC15985.1 - 0.0013 19.0 0.1 0.0021 18.3 0.1 1.5 1 1 0 1 1 1 1 Rubrerythrin PspA_IM30 PF04012.7 AIC15985.1 - 0.032 13.5 0.4 0.056 12.8 0.3 1.3 1 0 0 1 1 1 0 PspA/IM30 family PfkB PF00294.19 AIC15988.1 - 2.3e-24 86.0 0.0 3.1e-24 85.6 0.0 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase SUD-M PF11633.3 AIC15988.1 - 0.032 13.5 0.1 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Single-stranded poly(A) binding domain Flavoprotein PF02441.14 AIC15989.1 - 6.2e-30 103.5 0.6 7.7e-30 103.2 0.1 1.4 2 0 0 2 2 2 1 Flavoprotein CofC PF01983.11 AIC15989.1 - 0.079 11.9 0.0 0.18 10.7 0.0 1.5 2 0 0 2 2 2 0 Guanylyl transferase CofC like GvpH PF05455.6 AIC15990.1 - 6.1e-06 25.9 0.0 6.6e-06 25.8 0.0 1.1 1 0 0 1 1 1 1 GvpH HSP20 PF00011.16 AIC15990.1 - 0.088 12.6 0.1 9.1 6.2 0.0 2.5 2 1 1 3 3 3 0 Hsp20/alpha crystallin family Cas_Cas4 PF01930.12 AIC15991.1 - 4.9e-17 62.3 0.1 5.8e-17 62.0 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.2 AIC15991.1 - 4.4e-06 26.2 0.4 1.4e-05 24.6 0.1 1.6 1 1 1 2 2 2 1 PD-(D/E)XK nuclease superfamily Exo5 PF09810.4 AIC15991.1 - 0.059 12.5 0.2 0.37 9.9 0.0 2.1 2 1 0 2 2 2 0 Exonuclease V - a 5' deoxyribonuclease CRISPR_Cas2 PF09827.4 AIC15992.1 - 1.4e-13 50.8 1.0 1.5e-13 50.6 0.7 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas2 Cas_Cas1 PF01867.11 AIC15993.1 - 1.2e-72 244.4 0.0 1.4e-72 244.2 0.0 1.0 1 0 0 1 1 1 1 CRISPR associated protein Cas1 DEAD PF00270.24 AIC15995.1 - 1.3e-13 50.7 0.0 7.8e-12 45.0 0.0 2.4 2 0 0 2 2 2 1 DEAD/DEAH box helicase HDOD PF08668.7 AIC15995.1 - 1.1e-06 28.0 0.0 2.3e-06 27.0 0.0 1.5 1 0 0 1 1 1 1 HDOD domain HD PF01966.17 AIC15995.1 - 2.3e-06 27.6 0.1 6.1e-06 26.2 0.1 1.8 1 0 0 1 1 1 1 HD domain AAA_19 PF13245.1 AIC15995.1 - 0.00011 21.8 0.0 0.018 14.7 0.0 2.8 2 0 0 2 2 2 1 Part of AAA domain ResIII PF04851.10 AIC15995.1 - 0.0013 18.5 0.2 0.0081 16.0 0.0 2.4 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit AAA_22 PF13401.1 AIC15995.1 - 0.0015 18.7 0.0 0.01 15.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain TetR_C_3 PF08362.6 AIC15995.1 - 0.0026 17.4 0.0 0.0084 15.8 0.0 1.8 2 0 0 2 2 2 1 YcdC-like protein, C-terminal region Helicase_C PF00271.26 AIC15995.1 - 0.014 15.2 0.0 0.067 13.0 0.0 2.3 2 0 0 2 2 2 0 Helicase conserved C-terminal domain Cas_Cas5d PF09704.5 AIC15996.1 - 4.5e-10 39.5 0.0 5.4e-10 39.2 0.0 1.2 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas5) DUF694 PF05107.7 AIC15997.1 - 3.2e-40 138.0 0.1 4.3e-40 137.6 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF694) DUF2527 PF10736.4 AIC15998.1 - 0.021 14.4 0.2 0.067 12.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) KH_1 PF00013.24 AIC15999.1 - 5e-16 58.0 5.7 2e-08 33.7 1.0 2.3 2 0 0 2 2 2 2 KH domain KH_3 PF13014.1 AIC15999.1 - 4.1e-09 35.8 5.5 5.9e-05 22.6 0.4 2.4 2 0 0 2 2 2 2 KH domain KH_2 PF07650.12 AIC15999.1 - 0.0003 20.3 2.0 0.24 10.9 0.1 2.4 2 0 0 2 2 2 2 KH domain KH_4 PF13083.1 AIC15999.1 - 0.095 12.3 0.9 3.2 7.4 0.0 2.6 2 0 0 2 2 2 0 KH domain DUF3343 PF11823.3 AIC15999.1 - 0.12 11.7 0.2 0.3 10.3 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3343) RIO1 PF01163.17 AIC16000.1 - 5.4e-56 188.9 1.7 1.1e-55 187.9 0.0 1.9 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.20 AIC16000.1 - 2.5e-07 30.0 0.3 4.8e-07 29.2 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.18 AIC16000.1 - 2.5e-06 27.4 0.6 0.032 13.9 0.0 3.1 2 1 1 3 3 3 2 Phosphotransferase enzyme family Kdo PF06293.9 AIC16000.1 - 1.5e-05 24.1 0.0 7.2e-05 21.9 0.0 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.1 AIC16000.1 - 0.017 14.0 0.2 0.12 11.3 0.0 2.1 2 0 0 2 2 2 0 Kinase-like CHD5 PF04420.9 AIC16000.1 - 0.94 9.1 3.9 1.7 8.3 2.7 1.4 1 0 0 1 1 1 0 CHD5-like protein DUF424 PF04242.8 AIC16001.1 - 4.7e-15 55.4 0.0 5.2e-15 55.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF424) FAD_binding_6 PF00970.19 AIC16002.1 - 9.6e-14 51.3 0.0 1.5e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.16 AIC16002.1 - 7.3e-13 49.0 0.0 1.6e-12 47.9 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.7 AIC16002.1 - 0.14 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain T4SS PF07996.6 AIC16003.1 - 0.096 12.5 0.5 1.9 8.2 0.1 2.0 1 1 1 2 2 2 0 Type IV secretion system proteins Syntaxin-6_N PF09177.6 AIC16003.1 - 0.11 12.8 0.0 0.33 11.3 0.0 1.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal TRM PF02005.11 AIC16004.1 - 4.4e-92 308.8 0.0 5.4e-92 308.6 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.11 AIC16004.1 - 5.8e-05 22.7 0.0 0.00011 21.9 0.0 1.5 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.9 AIC16004.1 - 0.0019 17.6 0.1 0.0044 16.4 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.1 AIC16004.1 - 0.0032 17.0 0.0 0.0051 16.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain zf-C3HC4_3 PF13920.1 AIC16004.1 - 0.0037 16.8 0.5 0.01 15.4 0.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PrmA PF06325.8 AIC16004.1 - 0.0056 15.8 0.0 0.0083 15.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 AIC16004.1 - 0.009 16.0 0.1 0.018 15.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain DUF4023 PF13215.1 AIC16004.1 - 0.044 13.5 0.9 0.11 12.3 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) UPF0020 PF01170.13 AIC16004.1 - 0.052 13.1 0.0 0.096 12.2 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Transcrip_reg PF01709.15 AIC16004.1 - 0.096 11.8 0.0 0.17 11.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator Pup PF05639.6 AIC16004.1 - 0.14 12.6 0.2 0.36 11.3 0.0 1.7 2 0 0 2 2 1 0 Pup-like protein PALP PF00291.20 AIC16006.1 - 3e-21 75.9 0.5 2.3e-20 73.0 0.1 2.4 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme RNase_HII PF01351.13 AIC16007.1 - 4.5e-44 150.4 0.5 5.3e-44 150.2 0.3 1.0 1 0 0 1 1 1 1 Ribonuclease HII Fibrillarin PF01269.12 AIC16008.1 - 3.4e-84 281.3 0.0 3.9e-84 281.1 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin PCMT PF01135.14 AIC16008.1 - 0.00016 21.2 0.2 0.00023 20.7 0.1 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_18 PF12847.2 AIC16008.1 - 0.00074 20.0 0.0 0.0013 19.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 AIC16008.1 - 0.0016 19.2 0.0 0.0029 18.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC16008.1 - 0.021 14.8 0.0 0.063 13.3 0.0 1.8 2 1 0 2 2 2 0 Methyltransferase domain GCD14 PF08704.5 AIC16008.1 - 0.025 14.0 0.0 0.036 13.5 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_23 PF13489.1 AIC16008.1 - 0.12 12.1 0.0 0.26 11.0 0.0 1.7 1 1 0 1 1 1 0 Methyltransferase domain Nop PF01798.13 AIC16009.1 - 6.7e-52 174.7 2.6 1.3e-49 167.2 1.2 2.2 2 0 0 2 2 2 2 Putative snoRNA binding domain NOSIC PF08060.8 AIC16009.1 - 7.3e-19 67.3 0.1 7.5e-18 64.0 0.0 2.3 2 0 0 2 2 2 1 NOSIC (NUC001) domain TAF1D PF15333.1 AIC16009.1 - 0.0083 15.9 0.3 0.014 15.1 0.2 1.3 1 0 0 1 1 1 1 TATA box-binding protein-associated factor 1D Peptidase_S24 PF00717.18 AIC16011.1 - 8.7e-10 38.1 1.7 1.3e-09 37.5 0.5 1.8 1 1 1 2 2 2 1 Peptidase S24-like TrbC PF04956.8 AIC16011.1 - 0.49 10.4 3.9 2.2 8.3 0.1 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family UPF0047 PF01894.12 AIC16012.1 - 5.5e-38 129.4 0.0 6.4e-38 129.1 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 TBP PF00352.16 AIC16013.1 - 4.2e-61 202.3 0.1 5e-30 102.7 0.1 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.3 AIC16013.1 - 3.9e-06 26.8 0.0 0.0046 16.9 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) TPM PF04536.9 AIC16014.1 - 6.2e-13 48.6 0.0 1.5e-12 47.4 0.0 1.6 1 1 0 1 1 1 1 TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase Peripla_BP_4 PF13407.1 AIC16014.1 - 0.16 11.3 1.4 0.27 10.5 1.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein domain GRA6 PF05084.8 AIC16014.1 - 7.9 5.9 15.9 0.15 11.5 5.7 1.9 2 0 0 2 2 2 0 Granule antigen protein (GRA6) LemA PF04011.7 AIC16015.1 - 6e-47 159.1 0.7 7.2e-47 158.9 0.5 1.1 1 0 0 1 1 1 1 LemA family Pribosyltran PF00156.22 AIC16016.1 - 1.8e-14 53.5 3.5 3.3e-13 49.4 2.0 2.7 1 1 1 2 2 2 2 Phosphoribosyl transferase domain UPRTase PF14681.1 AIC16016.1 - 0.0018 17.4 0.1 0.0025 17.0 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.1 AIC16016.1 - 0.0041 16.4 0.1 0.0068 15.7 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase Peptidase_M50 PF02163.17 AIC16018.1 - 7.2e-18 64.2 6.4 1.9e-16 59.5 4.4 2.4 1 1 0 1 1 1 1 Peptidase family M50 Acetyltransf_1 PF00583.19 AIC16019.1 - 1.7e-18 66.4 0.2 2.5e-18 65.8 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.5 AIC16019.1 - 8.7e-10 38.2 0.2 1.7e-09 37.2 0.1 1.5 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_7 PF13508.1 AIC16019.1 - 8.7e-10 38.6 0.1 1.6e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 AIC16019.1 - 3.9e-09 36.6 0.0 5.6e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AIC16019.1 - 3.7e-07 30.0 0.0 9.5e-07 28.7 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AIC16019.1 - 5.1e-05 23.2 0.0 6.5e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.1 AIC16019.1 - 9.1e-05 22.3 0.0 0.00024 20.9 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.1 AIC16019.1 - 0.00033 20.8 0.1 0.00048 20.3 0.0 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain 4HB_MCP_1 PF12729.2 AIC16020.1 - 4.6e-08 32.6 4.7 5.5e-07 29.1 0.6 2.4 3 0 0 3 3 3 2 Four helix bundle sensory module for signal transduction DUF835 PF05763.7 AIC16020.1 - 0.00011 21.7 0.0 0.00024 20.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF835) VMA21 PF09446.5 AIC16020.1 - 3.2 7.7 8.8 0.18 11.7 0.6 2.7 3 0 0 3 3 3 0 VMA21-like domain Dodecin PF07311.7 AIC16021.1 - 2.4e-21 75.5 2.6 2.6e-21 75.3 1.8 1.0 1 0 0 1 1 1 1 Dodecin Sigma70_r2 PF04542.9 AIC16021.1 - 0.12 11.9 0.1 0.57 9.8 0.0 1.8 2 0 0 2 2 2 0 Sigma-70 region 2 AXH PF08517.7 AIC16021.1 - 0.15 12.2 0.2 0.17 12.0 0.2 1.0 1 0 0 1 1 1 0 Ataxin-1 and HBP1 module (AXH) Jag_N PF14804.1 AIC16021.1 - 0.47 10.5 2.0 0.5 10.4 0.1 1.8 2 0 0 2 2 2 0 Jag N-terminus DUF2157 PF09925.4 AIC16022.1 - 0.005 16.4 2.5 0.0063 16.1 1.8 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2157) Cytochrom_B_C PF00032.12 AIC16022.1 - 0.012 15.8 0.4 0.014 15.5 0.3 1.1 1 0 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD Cytochrom_B_N PF00033.14 AIC16022.1 - 0.035 13.4 1.8 0.037 13.3 1.2 1.0 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB DUF350 PF03994.9 AIC16022.1 - 0.043 13.5 3.7 0.5 10.1 0.1 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF350) Phage_holin_1 PF04531.8 AIC16022.1 - 0.11 12.6 1.2 0.13 12.3 0.8 1.1 1 0 0 1 1 1 0 Bacteriophage holin Yip1 PF04893.12 AIC16022.1 - 0.53 9.7 8.3 0.62 9.5 5.7 1.0 1 0 0 1 1 1 0 Yip1 domain IncA PF04156.9 AIC16022.1 - 0.65 9.5 3.7 0.76 9.3 2.6 1.1 1 0 0 1 1 1 0 IncA protein Tetraspannin PF00335.15 AIC16022.1 - 0.95 8.6 3.4 1.1 8.4 2.4 1.0 1 0 0 1 1 1 0 Tetraspanin family DUF1469 PF07332.6 AIC16022.1 - 1.2 8.8 7.6 1.5 8.5 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) TMEMspv1-c74-12 PF11044.3 AIC16022.1 - 1.3 8.6 3.5 2.4 7.7 2.4 1.5 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein YjgP_YjgQ PF03739.9 AIC16022.1 - 4 6.0 5.8 4.2 6.0 4.0 1.0 1 0 0 1 1 1 0 Predicted permease YjgP/YjgQ family DUF4307 PF14155.1 AIC16022.1 - 5 6.9 8.1 8.7 6.1 1.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) MMPL PF03176.10 AIC16022.1 - 6.3 5.3 9.3 6.6 5.3 6.5 1.0 1 0 0 1 1 1 0 MMPL family Met_10 PF02475.11 AIC16023.1 - 3e-64 216.2 0.8 4e-64 215.8 0.6 1.1 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.5 AIC16023.1 - 8.8e-08 31.8 0.0 1.4e-07 31.2 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_26 PF13659.1 AIC16023.1 - 1e-05 25.5 0.1 1.9e-05 24.6 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC16023.1 - 0.00013 22.4 0.0 0.00026 21.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.8 AIC16023.1 - 0.0003 20.0 1.1 0.00037 19.7 0.1 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 AIC16023.1 - 0.0011 18.4 0.0 0.0021 17.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltrans_SAM PF10672.4 AIC16023.1 - 0.022 13.6 0.0 0.033 13.0 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase ADH_zinc_N PF00107.21 AIC16023.1 - 0.032 13.7 0.1 0.076 12.5 0.0 1.8 1 1 0 1 1 1 0 Zinc-binding dehydrogenase ABC_tran PF00005.22 AIC16024.1 - 6.9e-38 130.0 0.0 8.5e-18 64.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.14 AIC16024.1 - 9.6e-12 44.6 0.3 0.00018 20.8 0.2 3.1 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.1 AIC16024.1 - 5.1e-11 43.0 3.3 0.079 12.9 0.0 4.3 2 2 1 3 3 3 3 AAA domain RLI PF04068.10 AIC16024.1 - 3.7e-10 39.2 1.4 9.2e-10 37.9 0.9 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI Fer4 PF00037.22 AIC16024.1 - 8e-08 31.5 3.3 8e-08 31.5 2.3 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_6 PF12837.2 AIC16024.1 - 1.1e-05 25.0 12.2 9.3e-05 22.1 1.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain SbcCD_C PF13558.1 AIC16024.1 - 6.5e-05 22.7 0.2 0.33 10.9 0.1 2.7 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit AAA_25 PF13481.1 AIC16024.1 - 9.7e-05 21.8 0.2 0.13 11.6 0.0 2.9 3 0 0 3 3 3 1 AAA domain Fer4_21 PF14697.1 AIC16024.1 - 0.00015 21.5 10.2 0.00025 20.8 7.1 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_7 PF12838.2 AIC16024.1 - 0.00028 21.1 9.8 0.00089 19.5 6.9 1.8 1 1 1 2 2 2 1 4Fe-4S dicluster domain AAA_29 PF13555.1 AIC16024.1 - 0.0005 19.5 0.2 0.026 14.0 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain DUF258 PF03193.11 AIC16024.1 - 0.00052 19.2 0.1 0.01 15.0 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function, DUF258 Miro PF08477.8 AIC16024.1 - 0.00053 20.4 0.1 0.59 10.6 0.0 3.1 3 0 0 3 3 2 1 Miro-like protein Fer4_11 PF13247.1 AIC16024.1 - 0.00072 19.4 3.2 0.0013 18.5 2.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 AIC16024.1 - 0.0008 19.1 11.0 0.003 17.3 1.3 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain MMR_HSR1 PF01926.18 AIC16024.1 - 0.00098 19.0 0.1 0.12 12.3 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.1 AIC16024.1 - 0.0035 17.3 1.8 1.2 9.0 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain Fer4_10 PF13237.1 AIC16024.1 - 0.0036 17.0 1.5 0.0036 17.0 1.1 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain AAA_17 PF13207.1 AIC16024.1 - 0.005 17.6 1.6 4.8 8.0 0.1 3.4 2 2 0 2 2 2 0 AAA domain AAA_23 PF13476.1 AIC16024.1 - 0.0075 16.6 0.0 1 9.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain Fer4_9 PF13187.1 AIC16024.1 - 0.01 16.0 11.9 0.021 15.0 8.2 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_16 PF13484.1 AIC16024.1 - 0.016 15.9 0.1 0.016 15.9 0.1 2.4 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain Fer4_3 PF12798.2 AIC16024.1 - 0.018 15.5 3.7 0.018 15.5 2.5 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_8 PF13183.1 AIC16024.1 - 0.018 15.0 4.4 0.039 13.9 3.0 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain NB-ARC PF00931.17 AIC16024.1 - 0.033 13.0 1.0 0.27 10.0 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain ATP_bind_1 PF03029.12 AIC16024.1 - 0.067 12.7 0.4 5 6.6 0.0 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_15 PF13175.1 AIC16024.1 - 0.069 12.1 0.0 5.8 5.8 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain Septin PF00735.13 AIC16024.1 - 0.082 11.9 0.1 11 4.9 0.0 2.2 2 0 0 2 2 2 0 Septin FeoB_N PF02421.13 AIC16024.1 - 0.099 11.9 0.6 1.7 7.9 0.0 2.4 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_33 PF13671.1 AIC16024.1 - 0.1 12.4 1.1 6.3 6.6 0.0 3.1 4 0 0 4 4 2 0 AAA domain AAA_28 PF13521.1 AIC16024.1 - 0.11 12.4 0.6 51 3.7 0.0 3.6 4 0 0 4 4 4 0 AAA domain MobB PF03205.9 AIC16024.1 - 0.12 12.1 4.9 0.94 9.1 0.0 3.2 3 0 0 3 3 3 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_14 PF13173.1 AIC16024.1 - 0.12 12.2 0.3 9.9 6.0 0.0 3.3 4 0 0 4 4 3 0 AAA domain KAP_NTPase PF07693.9 AIC16024.1 - 0.13 11.2 0.0 0.21 10.5 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain Dynamin_N PF00350.18 AIC16024.1 - 0.17 11.7 1.8 15 5.3 0.0 2.5 2 0 0 2 2 2 0 Dynamin family UPF0079 PF02367.12 AIC16024.1 - 0.19 11.3 0.7 10 5.7 0.1 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 Fer4_4 PF12800.2 AIC16024.1 - 0.4 11.1 11.4 0.13 12.6 1.6 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain AAA_22 PF13401.1 AIC16024.1 - 1.9 8.6 4.2 20 5.3 0.1 3.5 3 1 0 3 3 2 0 AAA domain ArgK PF03308.11 AIC16024.1 - 2 7.1 4.9 1.1 7.9 0.2 2.3 3 0 0 3 3 2 0 ArgK protein HTH_24 PF13412.1 AIC16027.1 - 8.6e-07 28.2 0.1 2e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.15 AIC16027.1 - 2.1e-05 24.1 0.0 4.8e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_AsnC-type PF13404.1 AIC16027.1 - 3.5e-05 23.2 0.0 0.00021 20.7 0.0 2.1 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HMA PF00403.21 AIC16027.1 - 0.0044 17.1 0.7 0.01 15.9 0.5 1.5 1 0 0 1 1 1 1 Heavy-metal-associated domain HTH_Mga PF08280.6 AIC16027.1 - 0.0046 16.6 0.0 0.021 14.5 0.0 2.1 1 1 1 2 2 2 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_9 PF08221.6 AIC16027.1 - 0.0049 16.7 0.0 0.013 15.3 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_20 PF12840.2 AIC16027.1 - 0.0069 16.1 0.0 0.023 14.5 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.2 AIC16027.1 - 0.014 15.0 0.0 0.028 14.0 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_45 PF14947.1 AIC16027.1 - 0.037 13.8 0.0 0.086 12.6 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix HTH_IclR PF09339.5 AIC16027.1 - 0.047 13.2 0.0 0.13 11.9 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_11 PF08279.7 AIC16027.1 - 0.052 13.1 0.1 0.18 11.4 0.0 1.9 2 0 0 2 2 2 0 HTH domain Cache_2 PF08269.6 AIC16028.1 - 0.11 12.5 0.0 7 6.6 0.0 2.3 2 0 0 2 2 2 0 Cache domain Peptidase_M17 PF00883.16 AIC16029.1 - 8.9e-115 382.8 0.1 1.1e-114 382.5 0.0 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.12 AIC16029.1 - 5e-21 74.7 0.3 1.3e-20 73.3 0.0 1.9 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain DUF1294 PF06961.8 AIC16029.1 - 0.042 13.8 0.0 0.097 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) Med25_VWA PF11265.3 AIC16029.1 - 0.06 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A FYRN PF05964.9 AIC16030.1 - 0.0044 16.4 0.0 0.0088 15.4 0.0 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus Transketolase_N PF00456.16 AIC16031.1 - 2.4e-65 220.5 0.0 3.8e-65 219.8 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Ribul_P_3_epim PF00834.14 AIC16031.1 - 4.2e-58 195.7 0.1 6.1e-58 195.2 0.1 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family E1_dh PF00676.15 AIC16031.1 - 1.1e-08 34.1 0.0 2e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.1 AIC16031.1 - 7.6e-08 31.6 0.2 0.00048 19.1 0.1 3.0 2 1 1 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.16 AIC16031.1 - 0.00029 20.4 0.2 0.0036 16.8 0.1 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Radical_SAM PF04055.16 AIC16031.1 - 0.029 14.5 0.1 5.6 7.1 0.0 3.7 3 1 0 3 3 3 0 Radical SAM superfamily Transket_pyr PF02779.19 AIC16032.1 - 2.1e-35 121.8 0.0 3.2e-35 121.2 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.15 AIC16032.1 - 3.2e-29 101.3 1.4 4e-29 101.0 0.2 1.8 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transaldolase PF00923.14 AIC16033.1 - 3.3e-60 203.6 0.3 4.8e-59 199.8 0.2 2.1 1 1 0 1 1 1 1 Transaldolase VWA PF00092.23 AIC16034.1 - 3.8e-07 29.9 0.0 1.1e-06 28.4 0.0 1.8 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.1 AIC16034.1 - 1.5e-05 25.1 0.0 2.5e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.4 AIC16034.1 - 0.025 14.4 0.0 0.083 12.7 0.0 1.9 1 0 0 1 1 1 0 vWA found in TerF C terminus VWA_3 PF13768.1 AIC16034.1 - 0.027 14.1 0.0 0.057 13.1 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF3507 PF12015.3 AIC16034.1 - 0.06 12.8 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3507) AAA_5 PF07728.9 AIC16035.1 - 2e-28 98.8 0.0 2.9e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.6 AIC16035.1 - 7.6e-12 44.9 0.0 1.1e-11 44.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.24 AIC16035.1 - 2.3e-07 31.0 0.0 4.1e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.1 AIC16035.1 - 2.3e-06 27.7 0.1 4.9e-06 26.6 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.1 AIC16035.1 - 3.8e-06 26.8 0.0 6.5e-06 26.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 AIC16035.1 - 7.5e-06 25.8 0.1 1.2e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase MCM PF00493.18 AIC16035.1 - 2.7e-05 23.1 0.0 4.6e-05 22.3 0.0 1.3 1 1 0 1 1 1 1 MCM2/3/5 family RuvB_N PF05496.7 AIC16035.1 - 4.2e-05 22.6 0.1 0.00071 18.6 0.1 2.1 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus MobB PF03205.9 AIC16035.1 - 4.4e-05 23.2 0.1 7.2e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_17 PF13207.1 AIC16035.1 - 6.8e-05 23.6 0.1 0.00012 22.8 0.1 1.7 1 1 0 1 1 1 1 AAA domain KAP_NTPase PF07693.9 AIC16035.1 - 7.6e-05 21.8 0.0 0.00011 21.3 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain AAA_22 PF13401.1 AIC16035.1 - 0.00011 22.3 0.2 0.00027 21.0 0.1 1.7 1 1 0 1 1 1 1 AAA domain NACHT PF05729.7 AIC16035.1 - 0.00025 20.7 0.0 0.00043 19.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Mg_chelatase PF01078.16 AIC16035.1 - 0.00058 19.0 0.2 0.48 9.5 0.0 2.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.1 AIC16035.1 - 0.0007 19.6 0.0 0.0037 17.3 0.0 2.2 2 1 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activat PF00158.21 AIC16035.1 - 0.0008 18.9 0.1 0.0024 17.3 0.1 1.7 1 1 0 1 1 1 1 Sigma-54 interaction domain SRP54 PF00448.17 AIC16035.1 - 0.0012 18.3 0.1 0.0021 17.5 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain UPF0079 PF02367.12 AIC16035.1 - 0.0014 18.2 0.0 0.003 17.1 0.0 1.6 1 0 0 1 1 1 1 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 AIC16035.1 - 0.0016 18.0 0.3 0.0048 16.4 0.2 1.9 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.1 AIC16035.1 - 0.0017 18.0 0.0 0.0046 16.6 0.0 1.7 1 0 0 1 1 1 1 Part of AAA domain AAA_11 PF13086.1 AIC16035.1 - 0.0018 17.9 0.0 0.0025 17.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.1 AIC16035.1 - 0.0018 18.2 0.1 0.0056 16.6 0.0 1.8 2 0 0 2 2 2 1 AAA domain Miro PF08477.8 AIC16035.1 - 0.0024 18.3 0.1 0.0064 16.9 0.0 1.7 2 0 0 2 2 1 1 Miro-like protein NTPase_1 PF03266.10 AIC16035.1 - 0.003 17.3 0.1 0.005 16.5 0.1 1.4 1 0 0 1 1 1 1 NTPase AAA_33 PF13671.1 AIC16035.1 - 0.0044 16.8 0.0 0.0079 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 AIC16035.1 - 0.0045 17.2 0.1 0.014 15.6 0.0 1.6 1 1 0 1 1 1 1 ABC transporter T2SE PF00437.15 AIC16035.1 - 0.0048 15.8 0.0 0.0093 14.8 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein RNA_helicase PF00910.17 AIC16035.1 - 0.0074 16.4 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.1 AIC16035.1 - 0.0078 16.5 0.2 0.014 15.6 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AIC16035.1 - 0.0094 15.3 0.1 0.023 14.1 0.1 1.6 1 1 0 1 1 1 1 AAA domain CbbQ_C PF08406.5 AIC16035.1 - 0.013 15.4 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal AAA_24 PF13479.1 AIC16035.1 - 0.014 15.0 0.4 0.023 14.2 0.3 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.12 AIC16035.1 - 0.018 14.4 0.0 0.03 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein KaiC PF06745.8 AIC16035.1 - 0.02 13.9 0.0 0.033 13.2 0.0 1.3 1 0 0 1 1 1 0 KaiC DUF258 PF03193.11 AIC16035.1 - 0.024 13.8 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_29 PF13555.1 AIC16035.1 - 0.03 13.8 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.1 AIC16035.1 - 0.053 13.8 0.0 0.072 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_35 PF14516.1 AIC16035.1 - 0.054 12.1 0.0 0.12 10.9 0.0 1.5 1 1 1 2 2 2 0 AAA-like domain ATP_bind_1 PF03029.12 AIC16035.1 - 0.06 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF815 PF05673.8 AIC16035.1 - 0.083 11.7 0.1 0.19 10.5 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF815) PhoH PF02562.11 AIC16035.1 - 0.12 11.5 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Hemerythrin PF01814.18 AIC16036.1 - 9.6e-12 45.2 1.4 1.9e-11 44.2 0.2 1.8 1 1 1 2 2 2 1 Hemerythrin HHE cation binding domain CwfJ_C_2 PF04676.9 AIC16036.1 - 0.043 14.3 0.1 0.077 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein similar to CwfJ C-terminus 2 Cu-oxidase_3 PF07732.10 AIC16037.1 - 2.1e-26 91.9 1.6 2.6e-21 75.5 0.0 2.6 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 AIC16037.1 - 2.3e-19 69.2 6.4 3.8e-08 32.9 0.1 3.8 4 0 0 4 4 4 3 Multicopper oxidase Copper-bind PF00127.15 AIC16037.1 - 4.3e-11 42.9 1.4 1.3e-05 25.3 0.0 3.9 2 2 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC16037.1 - 2.2e-08 33.9 0.0 0.00021 21.1 0.0 3.7 3 1 0 3 3 3 1 Cupredoxin-like domain Cu-oxidase PF00394.17 AIC16037.1 - 0.0011 18.9 0.0 0.11 12.3 0.0 2.8 2 0 0 2 2 2 1 Multicopper oxidase SH3_2 PF07653.12 AIC16037.1 - 0.045 13.2 0.0 7 6.2 0.0 2.5 2 0 0 2 2 2 0 Variant SH3 domain DUF2345 PF10106.4 AIC16037.1 - 0.18 11.4 3.4 0.15 11.6 0.4 2.2 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2345) YbgS PF13985.1 AIC16037.1 - 0.63 9.9 6.5 0.079 12.8 0.4 2.1 2 0 0 2 2 2 0 YbgS-like protein ABM PF03992.11 AIC16038.1 - 2e-06 27.7 0.1 2.7e-06 27.3 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase HicB PF05534.7 AIC16039.1 - 0.059 12.9 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 HicB family PPDK_N PF01326.14 AIC16043.1 - 0.065 12.2 0.3 0.078 12.0 0.2 1.1 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain DUF385 PF04075.9 AIC16044.1 - 1.7e-12 47.4 0.0 2.1e-12 47.1 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF385) DUF2255 PF10012.4 AIC16044.1 - 0.0039 17.1 0.2 0.0044 16.9 0.1 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2255) Pyridox_oxidase PF01243.15 AIC16044.1 - 0.12 12.4 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase DUF4389 PF14333.1 AIC16045.1 - 0.27 10.9 1.8 0.44 10.2 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) DUF4342 PF14242.1 AIC16046.1 - 5.2e-22 77.4 2.0 6.3e-22 77.1 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4342) zinc_ribbon_2 PF13240.1 AIC16046.1 - 6.6e-08 31.8 4.1 1.2e-07 31.0 2.9 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 AIC16046.1 - 2.8e-07 30.2 0.3 4.1e-07 29.7 0.2 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC16046.1 - 1.2e-06 27.5 5.3 1.9e-06 26.8 3.7 1.3 1 0 0 1 1 1 1 zinc-ribbon domain UPF0547 PF10571.4 AIC16046.1 - 1.8e-05 24.3 4.4 3.1e-05 23.5 3.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 MreC PF04085.9 AIC16046.1 - 0.0034 16.8 0.1 0.0035 16.7 0.1 1.2 1 0 0 1 1 1 1 rod shape-determining protein MreC zf-NADH-PPase PF09297.6 AIC16046.1 - 0.009 15.5 0.1 0.016 14.6 0.1 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain NOB1_Zn_bind PF08772.6 AIC16046.1 - 0.02 14.6 1.1 0.035 13.9 0.8 1.5 1 1 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like DUF1936 PF09151.5 AIC16046.1 - 0.049 13.1 0.5 0.13 11.8 0.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1936) zf-HYPF PF07503.7 AIC16046.1 - 0.08 12.3 1.5 0.8 9.1 1.1 2.1 1 1 0 1 1 1 0 HypF finger Prok-RING_1 PF14446.1 AIC16046.1 - 0.085 12.6 1.1 0.14 11.8 0.8 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 Nudix_N_2 PF14803.1 AIC16046.1 - 0.21 11.3 0.1 0.21 11.3 0.1 2.0 2 0 0 2 2 2 0 Nudix N-terminal zinc_ribbon_4 PF13717.1 AIC16046.1 - 0.34 10.6 2.0 3 7.6 0.0 2.7 2 0 0 2 2 2 0 zinc-ribbon domain ADK_lid PF05191.9 AIC16046.1 - 0.46 10.1 3.2 12 5.6 0.1 2.6 3 0 0 3 3 3 0 Adenylate kinase, active site lid A2L_zn_ribbon PF08792.5 AIC16046.1 - 2.3 7.7 4.2 34 4.0 2.9 2.2 1 1 0 1 1 1 0 A2L zinc ribbon domain TF_Zn_Ribbon PF08271.7 AIC16046.1 - 2.9 7.2 4.8 16 4.9 3.3 2.2 1 1 0 1 1 1 0 TFIIB zinc-binding zf-LITAF-like PF10601.4 AIC16046.1 - 3.4 7.6 6.1 0.71 9.7 0.5 2.4 2 1 1 3 3 3 0 LITAF-like zinc ribbon domain AP_endonuc_2 PF01261.19 AIC16047.1 - 3.2e-11 42.9 0.3 6.6e-10 38.6 0.2 2.2 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel Endonuc_BglI PF14562.1 AIC16047.1 - 0.11 11.3 0.0 0.98 8.2 0.0 2.0 2 0 0 2 2 2 0 Restriction endonuclease BglI FtsA PF14450.1 AIC16047.1 - 0.12 12.1 0.1 0.6 9.9 0.0 2.0 2 0 0 2 2 2 0 Cell division protein FtsA Polysacc_deac_1 PF01522.16 AIC16048.1 - 5.7e-12 45.3 0.0 9.2e-12 44.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.10 AIC16048.1 - 0.12 11.2 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Wzy_C PF04932.10 AIC16049.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 O-Antigen ligase TPPK_C PF12555.3 AIC16051.1 - 0.063 13.0 1.0 2.2 8.0 0.3 2.9 3 0 0 3 3 3 0 Thiamine pyrophosphokinase C terminal DFF40 PF09230.5 AIC16051.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.1 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa SP_C-Propep PF08999.5 AIC16052.1 - 0.27 10.7 1.7 0.44 10.0 1.2 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Pterin_4a PF01329.14 AIC16053.1 - 6.5e-32 109.1 0.0 7.1e-32 109.0 0.0 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Mo-co_dimer PF03404.11 AIC16054.1 - 1.8e-05 24.3 0.1 6.6e-05 22.5 0.1 1.7 1 1 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Big_3_4 PF13754.1 AIC16054.1 - 0.00015 21.9 7.9 0.00015 21.9 5.5 2.6 2 2 0 2 2 2 1 Bacterial Ig-like domain (group 3) TIG PF01833.19 AIC16054.1 - 0.00021 21.2 2.5 0.00036 20.4 1.7 1.5 1 1 0 1 1 1 1 IPT/TIG domain DUF4625 PF15418.1 AIC16054.1 - 0.0016 18.5 0.1 0.58 10.2 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4625) PEGA PF08308.6 AIC16054.1 - 0.0045 16.7 0.3 0.017 14.8 0.0 2.1 1 1 0 2 2 2 1 PEGA domain Gmad2 PF10648.4 AIC16054.1 - 0.012 15.7 0.9 0.032 14.3 0.3 1.9 1 1 1 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination Ribosomal_L9_N PF01281.14 AIC16054.1 - 0.072 12.3 0.2 0.25 10.6 0.0 2.0 3 0 0 3 3 3 0 Ribosomal protein L9, N-terminal domain CarboxypepD_reg PF13620.1 AIC16054.1 - 1.2 9.2 5.8 2.8 8.0 3.0 2.6 1 1 0 1 1 1 0 Carboxypeptidase regulatory-like domain Pkinase PF00069.20 AIC16055.1 - 8.6e-37 126.6 0.0 1.1e-36 126.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.12 AIC16055.1 - 5.3e-24 84.6 0.0 6.8e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.18 AIC16055.1 - 0.00074 19.3 0.2 0.17 11.5 0.0 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.9 AIC16055.1 - 0.057 12.4 0.0 0.088 11.8 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VCBS PF13517.1 AIC16056.1 - 3.2e-14 53.0 33.8 8.9e-06 25.9 2.9 3.9 1 1 3 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella FG-GAP PF01839.18 AIC16056.1 - 3.3e-05 23.4 10.6 1.1 9.0 0.1 4.5 4 0 0 4 4 4 3 FG-GAP repeat DUF756 PF05506.7 AIC16056.1 - 0.0078 16.6 0.3 13 6.3 0.0 3.4 2 1 1 3 3 3 2 Domain of unknown function (DUF756) Ubie_methyltran PF01209.13 AIC16056.1 - 0.05 12.7 0.6 14 4.7 0.0 3.3 1 1 0 3 3 3 0 ubiE/COQ5 methyltransferase family HDPD PF02924.9 AIC16056.1 - 0.28 10.9 9.7 5.6 6.7 0.1 3.7 1 1 1 3 3 3 0 Bacteriophage lambda head decoration protein D PLAT PF01477.18 AIC16056.1 - 1.5 9.2 8.8 2.2 8.7 1.1 3.1 1 1 3 4 4 4 0 PLAT/LH2 domain Hexapep PF00132.19 AIC16057.1 - 1.4e-13 49.7 13.2 9.9e-05 21.6 0.1 4.6 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.1 AIC16057.1 - 0.00032 20.1 6.6 0.026 14.0 0.7 4.3 4 1 0 4 4 4 2 Hexapeptide repeat of succinyl-transferase MFS_1 PF07690.11 AIC16058.1 - 3.1e-34 118.2 39.1 3.1e-34 118.2 27.1 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.2 AIC16058.1 - 0.00078 19.1 0.5 0.0033 17.1 0.2 2.3 1 1 0 1 1 1 1 MFS_1 like family DUF2320 PF10082.4 AIC16059.1 - 0.15 10.7 0.1 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2320) Glyoxalase_2 PF12681.2 AIC16060.1 - 1.1e-11 45.2 0.0 1.3e-11 45.0 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 AIC16060.1 - 2.6e-07 30.6 0.0 4.3e-07 29.9 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Lon_C PF05362.8 AIC16061.1 - 3e-13 49.5 2.7 7.5e-13 48.2 1.9 1.6 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.1 AIC16061.1 - 0.0063 16.0 0.1 0.015 14.8 0.0 1.7 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase C5-epim_C PF06662.8 AIC16065.1 - 3e-17 62.5 3.4 7.2e-17 61.2 2.3 1.6 1 1 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus DUF1680 PF07944.7 AIC16065.1 - 0.001 17.4 0.8 0.01 14.1 0.5 1.9 1 1 1 2 2 2 2 Putative glycosyl hydrolase of unknown function (DUF1680) DUF1326 PF07040.6 AIC16066.1 - 8.2e-46 156.0 0.0 9.5e-46 155.8 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) HEAT_2 PF13646.1 AIC16067.1 - 0.042 14.1 0.8 0.061 13.6 0.5 1.3 1 1 0 1 1 1 0 HEAT repeats Med8 PF10232.4 AIC16067.1 - 0.096 12.1 1.6 0.12 11.9 1.1 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Asp-B-Hydro_N PF05279.6 AIC16067.1 - 0.25 11.1 5.7 0.28 11.0 3.9 1.0 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region CENP-F_leu_zip PF10473.4 AIC16067.1 - 0.32 10.8 4.0 5.6 6.8 2.8 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cellulase PF00150.13 AIC16068.1 - 1.1e-14 54.3 2.3 4e-14 52.4 1.6 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.19 AIC16068.1 - 0.0028 16.9 0.0 1.7 7.8 0.0 2.4 1 1 0 2 2 2 2 Xylose isomerase-like TIM barrel DUF3227 PF11537.3 AIC16070.1 - 0.015 15.3 0.0 0.017 15.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3227) SicP-binding PF09119.5 AIC16070.1 - 0.13 12.0 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 SicP binding Zn-ribbon_8 PF09723.5 AIC16071.1 - 0.00014 21.7 15.2 0.022 14.7 0.6 4.3 3 1 1 4 4 4 2 Zinc ribbon domain OrfB_Zn_ribbon PF07282.6 AIC16071.1 - 0.017 14.7 0.5 0.017 14.7 0.3 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain DUF35_N PF12172.3 AIC16071.1 - 0.031 14.1 5.3 0.9 9.5 0.1 3.2 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Ribosomal_L37ae PF01780.14 AIC16071.1 - 0.038 13.8 3.6 0.055 13.3 0.5 2.3 1 1 1 2 2 2 0 Ribosomal L37ae protein family C1_1 PF00130.17 AIC16071.1 - 0.12 12.0 6.2 0.54 10.0 0.8 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.5 AIC16071.1 - 0.19 11.2 12.3 0.22 11.0 0.3 3.6 4 0 0 4 4 4 0 A2L zinc ribbon domain zinc-ribbons_6 PF07191.7 AIC16071.1 - 0.29 10.9 11.1 2 8.2 1.6 3.3 1 1 2 3 3 3 0 zinc-ribbons DZR PF12773.2 AIC16071.1 - 0.79 9.5 10.0 5.5 6.8 0.4 2.6 1 1 1 2 2 2 0 Double zinc ribbon zf-Di19 PF05605.7 AIC16071.1 - 0.94 9.6 4.7 5.2 7.2 1.5 3.1 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-AN1 PF01428.11 AIC16071.1 - 1.9 8.4 12.1 6.1 6.7 1.1 3.1 2 1 1 3 3 3 0 AN1-like Zinc finger zf-C2H2 PF00096.21 AIC16071.1 - 2.6 8.5 16.6 2.4 8.6 0.7 3.8 4 0 0 4 4 3 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AIC16071.1 - 2.9 8.4 9.6 37 4.9 0.2 4.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-IS66 PF13005.2 AIC16071.1 - 3.5 7.6 8.2 1.6 8.7 0.0 3.8 4 0 0 4 4 4 0 zinc-finger binding domain of transposase IS66 HypA PF01155.14 AIC16071.1 - 5.6 6.7 9.8 78 3.0 0.4 3.7 2 1 1 3 3 3 0 Hydrogenase expression/synthesis hypA family zf-FPG_IleRS PF06827.9 AIC16071.1 - 6.4 6.5 10.2 17 5.1 0.0 3.6 4 0 0 4 4 3 0 Zinc finger found in FPG and IleRS Sgf11 PF08209.6 AIC16071.1 - 7.5 5.9 12.4 2.6 7.4 0.1 3.9 4 0 0 4 4 4 0 Sgf11 (transcriptional regulation protein) zf-RING_3 PF14369.1 AIC16071.1 - 8.3 6.5 9.3 23 5.1 0.2 3.5 2 1 1 3 3 3 0 zinc-finger Ribosomal_S27e PF01667.12 AIC16071.1 - 8.8 5.9 7.1 5 6.7 0.1 3.1 3 1 0 3 3 3 0 Ribosomal protein S27 CpXC PF14353.1 AIC16071.1 - 8.9 6.2 8.3 37 4.2 0.0 3.4 3 1 0 3 3 3 0 CpXC protein Ribosomal_L44 PF00935.14 AIC16071.1 - 9 6.3 7.8 30 4.6 0.5 3.2 2 1 1 3 3 3 0 Ribosomal protein L44 zf-Mss51 PF13824.1 AIC16071.1 - 10 6.0 10.7 3.9e+03 -2.2 7.4 3.1 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Glyco_tranf_2_3 PF13641.1 AIC16072.1 - 2.1e-37 129.1 0.1 2.7e-37 128.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 AIC16072.1 - 1e-24 87.3 4.3 1e-24 87.3 3.0 1.7 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.21 AIC16072.1 - 8.7e-14 51.5 0.0 1.4e-13 50.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.1 AIC16072.1 - 6.1e-09 35.4 0.6 1.4e-08 34.2 0.1 1.7 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 AIC16072.1 - 1.7e-05 24.0 0.0 3.4e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 DUF3270 PF11674.3 AIC16073.1 - 0.22 11.5 0.9 0.27 11.2 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3270) SelR PF01641.13 AIC16074.1 - 2e-37 127.6 0.0 2.3e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 SelR domain RIG-I_C-RD PF11648.3 AIC16074.1 - 0.0053 16.6 0.1 2.5 7.9 0.0 2.1 2 0 0 2 2 2 2 C-terminal domain of RIG-I Ribosomal_L37e PF01907.14 AIC16074.1 - 0.027 14.2 3.6 0.35 10.7 0.2 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e TF_Zn_Ribbon PF08271.7 AIC16074.1 - 0.09 12.1 0.9 2.3 7.6 0.1 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding HECT_2 PF09814.4 AIC16074.1 - 0.094 11.4 0.1 4.8 5.7 0.0 2.1 2 0 0 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zf-HIT PF04438.11 AIC16074.1 - 0.14 11.7 2.0 0.87 9.2 0.2 2.2 2 0 0 2 2 2 0 HIT zinc finger DZR PF12773.2 AIC16074.1 - 0.29 10.9 4.3 3.9 7.3 2.9 2.2 1 1 0 1 1 1 0 Double zinc ribbon RRN7 PF11781.3 AIC16074.1 - 7.3 6.1 7.3 3.2 7.3 1.2 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 PMSR PF01625.16 AIC16075.1 - 1.3e-63 213.5 0.3 1.5e-63 213.3 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase UvsY PF11056.3 AIC16076.1 - 0.086 12.9 1.4 20 5.3 0.2 3.0 2 1 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY Big_2 PF02368.13 AIC16079.1 - 0.68 9.8 6.0 7.4 6.5 1.3 2.6 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 2) DUF1942 PF09167.6 AIC16080.1 - 0.00059 19.5 1.7 0.011 15.5 0.2 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF1942) DUF677 PF05055.7 AIC16080.1 - 0.028 13.1 0.5 0.038 12.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) DUF460 PF04312.8 AIC16081.1 - 0.00027 20.4 0.1 0.00058 19.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF460) UPF0081 PF03652.10 AIC16081.1 - 0.067 13.3 0.1 0.53 10.4 0.1 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0081) Herpes_US12 PF05363.7 AIC16081.1 - 0.073 13.5 0.1 0.15 12.5 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus US12 family Exonuc_VII_L PF02601.10 AIC16082.1 - 0.0011 18.2 4.3 0.0012 18.0 3.0 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit ATP-synt_B PF00430.13 AIC16082.1 - 0.0013 18.5 13.7 0.0085 15.8 9.5 2.0 1 1 0 1 1 1 1 ATP synthase B/B' CF(0) Mitofilin PF09731.4 AIC16082.1 - 0.002 16.8 8.7 0.0025 16.5 6.0 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Mod_r PF07200.8 AIC16082.1 - 0.014 15.3 4.7 0.018 14.9 3.3 1.1 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CLTH PF10607.4 AIC16082.1 - 0.018 14.7 0.4 0.021 14.5 0.3 1.2 1 0 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain Phasin PF05597.6 AIC16082.1 - 0.02 14.6 8.1 0.41 10.4 2.1 2.4 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Apolipoprotein PF01442.13 AIC16082.1 - 0.021 14.3 4.1 0.025 14.0 2.9 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Reo_sigmaC PF04582.7 AIC16082.1 - 0.022 13.9 3.7 0.026 13.7 2.6 1.1 1 0 0 1 1 1 0 Reovirus sigma C capsid protein Activator-TraM PF11657.3 AIC16082.1 - 0.025 14.0 6.6 0.036 13.5 4.6 1.3 1 0 0 1 1 1 0 Transcriptional activator TraM Peptidase_M75 PF09375.5 AIC16082.1 - 0.033 13.5 1.3 0.038 13.3 0.9 1.1 1 0 0 1 1 1 0 Imelysin Phage_connect_1 PF05135.8 AIC16082.1 - 0.039 14.1 0.8 0.11 12.6 0.6 1.8 1 1 0 1 1 1 0 Phage gp6-like head-tail connector protein CsoSCA PF08936.5 AIC16082.1 - 0.045 12.1 1.9 0.071 11.4 1.3 1.4 1 1 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase COG6 PF06419.6 AIC16082.1 - 0.049 11.7 4.5 0.061 11.4 3.1 1.1 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Allexi_40kDa PF05549.6 AIC16082.1 - 0.051 12.8 2.2 0.061 12.6 1.5 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein HrpE PF06188.7 AIC16082.1 - 0.059 13.1 3.2 0.075 12.7 2.2 1.3 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E DUF4456 PF14644.1 AIC16082.1 - 0.065 12.4 4.7 0.22 10.7 2.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) OmpH PF03938.9 AIC16082.1 - 0.076 12.9 6.5 0.099 12.5 4.5 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Duffy_binding PF05424.6 AIC16082.1 - 0.077 12.8 1.9 0.11 12.3 1.3 1.3 1 0 0 1 1 1 0 Duffy binding domain PhdYeFM_antitox PF02604.14 AIC16082.1 - 0.085 12.4 2.6 0.6 9.7 0.0 2.7 1 1 1 2 2 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system DUF3552 PF12072.3 AIC16082.1 - 0.087 12.0 14.5 0.045 12.9 5.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DUF4211 PF13926.1 AIC16082.1 - 0.09 12.1 0.9 0.13 11.6 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4211) Herpes_U30 PF04523.8 AIC16082.1 - 0.11 9.9 1.5 0.14 9.6 1.0 1.0 1 0 0 1 1 1 0 Herpes virus tegument protein U30 DUF4142 PF13628.1 AIC16082.1 - 0.12 12.4 6.8 0.12 12.3 3.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4142) AAA_13 PF13166.1 AIC16082.1 - 0.12 10.8 6.8 0.13 10.6 4.7 1.1 1 0 0 1 1 1 0 AAA domain CDC37_N PF03234.9 AIC16082.1 - 0.13 12.6 6.5 0.15 12.3 4.5 1.1 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding Hyccin PF09790.4 AIC16082.1 - 0.13 11.1 1.5 0.14 10.9 1.0 1.2 1 0 0 1 1 1 0 Hyccin KfrA_N PF11740.3 AIC16082.1 - 0.14 12.6 8.0 0.6 10.5 3.7 2.2 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term DUF885 PF05960.6 AIC16082.1 - 0.15 11.2 3.5 0.16 11.0 2.4 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) Muted PF14942.1 AIC16082.1 - 0.16 11.8 5.2 0.21 11.4 3.6 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein VIT1 PF01988.14 AIC16082.1 - 0.19 11.1 5.3 0.25 10.8 3.7 1.2 1 0 0 1 1 1 0 VIT family Phage_Mu_Gam PF07352.7 AIC16082.1 - 0.24 10.9 9.9 0.15 11.5 0.5 2.2 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein COG5 PF10392.4 AIC16082.1 - 0.25 11.3 4.7 2.1 8.3 0.2 2.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF972 PF06156.8 AIC16082.1 - 0.25 11.7 7.2 0.84 10.0 5.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF972) DivIVA PF05103.8 AIC16082.1 - 0.26 11.3 14.1 0.18 11.8 7.9 1.8 1 1 1 2 2 2 0 DivIVA protein DUF1664 PF07889.7 AIC16082.1 - 0.27 11.0 7.8 0.11 12.3 1.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cob_adeno_trans PF01923.13 AIC16082.1 - 0.3 10.8 2.6 1.8 8.3 1.8 1.9 1 1 0 1 1 1 0 Cobalamin adenosyltransferase Translin PF01997.11 AIC16082.1 - 0.34 10.4 5.4 5.2 6.6 2.3 2.1 1 1 1 2 2 2 0 Translin family Baculo_PEP_C PF04513.7 AIC16082.1 - 0.37 10.6 2.6 6.1 6.6 1.3 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF883 PF05957.8 AIC16082.1 - 0.42 11.0 9.6 0.84 10.0 4.4 2.5 1 1 2 3 3 2 0 Bacterial protein of unknown function (DUF883) Glu_syn_central PF04898.9 AIC16082.1 - 0.54 9.4 4.8 1.6 7.9 2.3 1.9 2 0 0 2 2 2 0 Glutamate synthase central domain COG2 PF06148.6 AIC16082.1 - 0.55 10.1 7.2 0.41 10.5 3.9 1.7 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Uds1 PF15456.1 AIC16082.1 - 0.58 10.1 8.0 1.3 8.9 0.1 2.7 1 1 1 2 2 2 0 Up-regulated During Septation vATP-synt_E PF01991.13 AIC16082.1 - 0.61 9.3 13.9 0.97 8.6 9.0 1.8 1 1 0 1 1 1 0 ATP synthase (E/31 kDa) subunit V-ATPase_G PF03179.10 AIC16082.1 - 0.66 10.3 12.8 1.9 8.8 6.7 2.4 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit FlaC_arch PF05377.6 AIC16082.1 - 0.87 9.5 8.9 0.6 10.0 1.5 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) FliH PF02108.11 AIC16082.1 - 0.88 9.4 6.3 1.7 8.5 0.3 2.3 1 1 1 2 2 2 0 Flagellar assembly protein FliH AAA_11 PF13086.1 AIC16082.1 - 0.89 9.0 6.8 1.4 8.4 4.7 1.4 1 1 0 1 1 1 0 AAA domain DUF2894 PF11445.3 AIC16082.1 - 0.91 9.7 5.1 1.2 9.3 3.4 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) Fzo_mitofusin PF04799.8 AIC16082.1 - 1.4 8.2 4.4 2.6 7.3 1.1 2.0 1 1 1 2 2 2 0 fzo-like conserved region LUC7 PF03194.10 AIC16082.1 - 2.2 7.7 7.6 2.8 7.4 5.3 1.2 1 0 0 1 1 1 0 LUC7 N_terminus XhlA PF10779.4 AIC16082.1 - 2.5 8.0 10.4 7.3e+02 0.1 7.2 2.5 1 1 0 1 1 1 0 Haemolysin XhlA HSCB_C PF07743.8 AIC16082.1 - 3 8.3 10.0 2.3e+02 2.3 6.9 2.2 1 1 0 1 1 1 0 HSCB C-terminal oligomerisation domain Lge1 PF11488.3 AIC16082.1 - 4 7.6 8.2 4.8 7.4 0.6 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 Spc24 PF08286.6 AIC16082.1 - 4.9 6.8 7.6 26 4.5 5.2 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF2175 PF09943.4 AIC16082.1 - 5.3 7.1 7.2 4 7.5 3.7 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) DUF2203 PF09969.4 AIC16082.1 - 5.6 7.1 6.3 72 3.6 4.3 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) V-SNARE PF05008.10 AIC16082.1 - 7.2 6.8 10.7 4.5 7.4 1.0 2.5 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus ISG65-75 PF11727.3 AIC16082.1 - 8.3 5.3 13.7 14 4.5 5.4 1.8 1 1 1 2 2 2 0 Invariant surface glycoprotein NAC PF01849.13 AIC16083.1 - 9e-13 47.5 4.1 5.1e-11 41.9 1.4 2.1 2 0 0 2 2 2 2 NAC domain UBA PF00627.26 AIC16083.1 - 6.6e-05 22.6 0.1 0.00016 21.4 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain CUE PF02845.11 AIC16083.1 - 0.11 12.0 0.1 0.93 9.0 0.0 2.4 2 1 1 3 3 3 0 CUE domain PUA PF01472.15 AIC16084.1 - 4.7e-11 42.2 0.4 7.2e-11 41.6 0.3 1.3 1 0 0 1 1 1 1 PUA domain TGT_C2 PF14810.1 AIC16084.1 - 1.6e-10 40.6 0.0 2.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 Patch-forming domain C2 of tRNA-guanine transglycosylase PhoU PF01895.14 AIC16085.1 - 1.8e-25 89.1 18.5 1.3e-17 64.0 2.5 2.8 3 0 0 3 3 3 2 PhoU domain Antitoxin-MazE PF04014.13 AIC16085.1 - 1.4e-09 37.4 0.0 3.5e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 Antidote-toxin recognition MazE HSBP1 PF06825.7 AIC16085.1 - 0.016 14.7 0.3 0.034 13.7 0.2 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 HTH_3 PF01381.17 AIC16086.1 - 2.2e-05 24.2 0.1 3.3e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.1 AIC16086.1 - 0.00051 20.1 0.0 0.00077 19.6 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.2 AIC16086.1 - 0.048 13.7 0.2 0.083 12.9 0.2 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_25 PF13413.1 AIC16086.1 - 0.11 12.1 0.1 0.2 11.3 0.0 1.5 1 1 0 1 1 1 0 Helix-turn-helix domain zf-dskA_traR PF01258.12 AIC16086.1 - 0.16 11.7 0.6 0.47 10.2 0.4 1.8 1 1 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger MMR_HSR1 PF01926.18 AIC16087.1 - 1.8e-18 66.5 0.1 8.7e-18 64.3 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.1 AIC16087.1 - 2.5e-12 46.7 0.6 1.3e-11 44.4 0.0 2.4 3 0 0 3 3 3 1 GTP-binding GTPase N-terminal FeoB_N PF02421.13 AIC16087.1 - 3.9e-08 32.7 0.0 1.2e-07 31.1 0.0 1.9 1 0 0 1 1 1 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 AIC16087.1 - 7.3e-06 25.5 0.2 0.0023 17.3 0.1 2.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.5 AIC16087.1 - 0.0024 17.1 0.2 0.0024 17.1 0.1 2.4 2 1 1 3 3 3 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.22 AIC16087.1 - 0.0037 17.5 0.1 0.015 15.6 0.0 2.2 1 1 1 2 2 2 1 ABC transporter Miro PF08477.8 AIC16087.1 - 0.013 16.0 0.0 0.033 14.7 0.0 1.8 1 0 0 1 1 1 0 Miro-like protein Dynamin_N PF00350.18 AIC16087.1 - 0.029 14.2 2.0 0.25 11.1 0.1 2.8 2 2 2 4 4 4 0 Dynamin family DUF258 PF03193.11 AIC16087.1 - 0.082 12.0 0.3 0.24 10.5 0.2 2.0 1 1 0 1 1 1 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 AIC16087.1 - 0.085 12.3 0.2 0.58 9.6 0.1 2.3 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.1 AIC16087.1 - 5.2 7.3 6.7 5.9 7.1 0.2 2.3 2 0 0 2 2 2 0 AAA domain Trm56 PF01994.11 AIC16088.1 - 5.1e-52 174.7 0.2 6.6e-52 174.3 0.1 1.2 1 0 0 1 1 1 1 tRNA ribose 2'-O-methyltransferase, aTrm56 Glyoxalase_4 PF13669.1 AIC16088.1 - 0.058 13.4 0.0 0.077 13.0 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Lipoprot_C PF08794.5 AIC16088.1 - 0.11 12.3 0.1 0.16 11.8 0.1 1.3 1 0 0 1 1 1 0 Lipoprotein GNA1870 C terminal like AHSA1 PF08327.6 AIC16089.1 - 2.5e-22 79.2 0.1 2.8e-22 79.1 0.1 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.4 AIC16089.1 - 0.00027 21.1 0.2 0.00035 20.7 0.1 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.6 AIC16090.1 - 7.1e-24 84.2 0.3 1.1e-23 83.6 0.1 1.4 2 0 0 2 2 2 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.4 AIC16090.1 - 3.3e-12 46.7 2.4 1.3e-11 44.7 0.8 1.9 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 AIC16090.1 - 0.00084 19.3 0.1 0.0013 18.7 0.1 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport HTH_20 PF12840.2 AIC16091.1 - 2.4e-14 52.8 0.1 3.7e-14 52.2 0.1 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC16091.1 - 5.2e-14 51.6 0.0 6.9e-14 51.2 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.2 AIC16091.1 - 7.4e-06 25.5 0.1 1.3e-05 24.7 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.1 AIC16091.1 - 9.2e-06 24.9 0.0 1.4e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding TrmB PF01978.14 AIC16091.1 - 0.0023 17.5 0.0 0.0038 16.9 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 AIC16091.1 - 0.0028 17.3 0.0 0.0067 16.1 0.0 1.6 2 0 0 2 2 2 1 MarR family HTH_34 PF13601.1 AIC16091.1 - 0.0049 16.8 0.0 0.0082 16.1 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain Phage_rep_org_N PF09681.5 AIC16091.1 - 0.024 14.1 0.0 0.03 13.8 0.0 1.2 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) Rrf2 PF02082.15 AIC16091.1 - 0.028 14.5 0.0 0.042 13.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator TFIIE_alpha PF02002.12 AIC16091.1 - 0.078 12.4 0.0 0.11 11.9 0.0 1.4 1 1 0 1 1 1 0 TFIIE alpha subunit Sigma70_r4 PF04545.11 AIC16091.1 - 0.078 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-70, region 4 FeoC PF09012.5 AIC16091.1 - 0.13 12.0 0.0 2 8.2 0.0 2.2 2 1 0 2 2 2 0 FeoC like transcriptional regulator AMP-binding PF00501.23 AIC16093.1 - 2.4e-88 296.3 0.0 2.9e-88 296.0 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.1 AIC16093.1 - 8.7e-19 68.2 2.0 1.8e-18 67.2 1.4 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Peptidase_M1 PF01433.15 AIC16094.1 - 3.9e-74 250.0 0.9 6.8e-74 249.2 0.6 1.3 1 0 0 1 1 1 1 Peptidase family M1 HEAT_2 PF13646.1 AIC16094.1 - 4e-24 84.7 6.6 2e-10 40.8 0.0 4.0 1 1 3 4 4 4 3 HEAT repeats Peptidase_MA_2 PF13485.1 AIC16094.1 - 3.7e-16 59.3 1.6 9e-16 58.0 1.1 1.7 1 0 0 1 1 1 1 Peptidase MA superfamily HEAT_PBS PF03130.11 AIC16094.1 - 5.5e-12 44.9 9.8 0.029 14.8 0.2 5.9 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.17 AIC16094.1 - 2e-05 24.2 5.4 2.1 8.6 0.0 5.0 5 0 0 5 5 5 3 HEAT repeat HEAT_EZ PF13513.1 AIC16094.1 - 0.00082 19.7 9.0 0.016 15.7 0.3 3.8 3 1 0 3 3 3 1 HEAT-like repeat Abhydrolase_6 PF12697.2 AIC16095.1 - 1.6e-43 149.1 0.1 1.9e-43 148.9 0.1 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AIC16095.1 - 1.3e-18 67.1 0.0 7.2e-18 64.7 0.0 1.9 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.15 AIC16095.1 - 3.1e-18 66.1 0.0 2.8e-17 63.0 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.15 AIC16095.1 - 0.0005 19.5 0.1 0.00072 19.0 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.3 AIC16095.1 - 0.00066 19.4 0.0 0.0016 18.2 0.0 1.6 1 0 0 1 1 1 1 Putative lysophospholipase DUF2048 PF09752.4 AIC16095.1 - 0.0021 16.9 0.0 0.0025 16.7 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2048) Thioesterase PF00975.15 AIC16095.1 - 0.012 15.8 0.0 0.015 15.5 0.0 1.3 1 0 0 1 1 1 0 Thioesterase domain Abhydrolase_3 PF07859.8 AIC16095.1 - 0.015 14.8 0.2 0.034 13.7 0.2 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF829 PF05705.9 AIC16095.1 - 0.15 11.7 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Acetyltransf_1 PF00583.19 AIC16096.1 - 3.2e-14 52.7 0.1 6.2e-14 51.8 0.0 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.1 AIC16096.1 - 1.1e-11 45.1 0.1 3.6e-10 40.1 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 AIC16096.1 - 7.2e-08 32.5 0.4 2.6e-06 27.5 0.0 2.5 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AIC16096.1 - 1.1e-06 28.4 0.0 4e-06 26.7 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 AIC16096.1 - 3.6e-06 27.0 0.0 2.6e-05 24.2 0.0 2.3 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.1 AIC16096.1 - 3e-05 24.0 0.0 0.00012 22.1 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_6 PF13480.1 AIC16096.1 - 0.0025 17.7 0.2 0.014 15.3 0.0 2.2 2 1 1 3 3 3 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 AIC16096.1 - 0.0033 17.1 0.0 0.007 16.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Amb_V_allergen PF03913.8 AIC16096.1 - 0.086 12.5 0.2 0.69 9.6 0.0 2.2 2 0 0 2 2 2 0 Amb V Allergen dCMP_cyt_deam_1 PF00383.17 AIC16098.1 - 3.4e-24 84.4 1.0 4.9e-24 83.9 0.7 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.1 AIC16098.1 - 0.0019 17.8 0.1 0.0032 17.1 0.1 1.4 1 0 0 1 1 1 1 MafB19-like deaminase APOBEC_N PF08210.6 AIC16098.1 - 0.0057 16.2 0.2 0.0096 15.5 0.1 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain XOO_2897-deam PF14440.1 AIC16098.1 - 0.018 14.7 0.0 0.023 14.4 0.0 1.3 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Hemerythrin PF01814.18 AIC16099.1 - 0.0078 16.3 1.5 0.012 15.7 1.1 1.4 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain RecX PF02631.11 AIC16099.1 - 0.016 15.4 0.0 0.024 14.8 0.0 1.4 1 0 0 1 1 1 0 RecX family DUF3128 PF11326.3 AIC16099.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) PTS_EIIC PF02378.13 AIC16101.1 - 0.022 13.6 1.3 0.022 13.5 0.9 1.0 1 0 0 1 1 1 0 Phosphotransferase system, EIIC TMEM125 PF15109.1 AIC16101.1 - 0.15 12.1 0.0 0.16 12.0 0.0 1.1 1 0 0 1 1 1 0 TMEM125 protein family Thioredoxin_3 PF13192.1 AIC16102.1 - 2.9e-05 23.7 0.1 3.7e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin domain DUF4662 PF15578.1 AIC16103.1 - 0.06 12.9 0.0 0.06 12.9 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) DNA_pol_B_thumb PF14791.1 AIC16104.1 - 2e-24 85.0 0.1 5e-24 83.7 0.1 1.8 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.1 AIC16104.1 - 9.2e-17 60.9 8.4 1.4e-16 60.4 0.8 3.1 3 0 0 3 3 3 1 Helix-hairpin-helix domain HHH_5 PF14520.1 AIC16104.1 - 1.5e-10 41.0 15.6 6.9e-08 32.5 0.6 3.6 1 1 2 3 3 3 3 Helix-hairpin-helix domain PHP PF02811.14 AIC16104.1 - 4.3e-09 36.4 0.5 2.1e-08 34.1 0.1 2.1 2 0 0 2 2 2 1 PHP domain HHH PF00633.18 AIC16104.1 - 1e-05 24.9 4.9 0.031 13.9 0.2 3.7 3 0 0 3 3 3 2 Helix-hairpin-helix motif HHH_3 PF12836.2 AIC16104.1 - 0.00063 19.6 0.7 0.051 13.5 0.0 3.2 2 1 1 3 3 3 1 Helix-hairpin-helix motif HHH_2 PF12826.2 AIC16104.1 - 0.0032 17.3 0.0 0.32 10.8 0.0 2.9 1 1 2 3 3 3 1 Helix-hairpin-helix motif DNA_pol_B_palm PF14792.1 AIC16104.1 - 0.0043 17.0 0.0 0.012 15.6 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm IMS_HHH PF11798.3 AIC16104.1 - 0.077 13.0 0.8 7.2 6.8 0.0 3.7 3 1 1 4 4 4 0 IMS family HHH motif DUF4153 PF13687.1 AIC16105.1 - 0.061 12.8 4.2 3.2 7.1 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4153) Abhydrolase_9_N PF15420.1 AIC16105.1 - 0.066 12.9 1.8 0.085 12.5 1.2 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF4234 PF14018.1 AIC16105.1 - 7.8 6.3 9.6 4.6 7.0 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4234) Pyr_redox_2 PF07992.9 AIC16106.1 - 6.3e-21 75.1 0.0 8.1e-21 74.8 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.22 AIC16106.1 - 1.4e-05 25.3 0.1 0.02 15.3 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.1 AIC16106.1 - 0.0002 21.3 0.1 0.0005 20.0 0.1 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.19 AIC16106.1 - 0.0029 16.4 0.1 0.026 13.3 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.19 AIC16106.1 - 0.0036 16.2 0.3 0.0078 15.1 0.2 1.7 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.1 AIC16106.1 - 0.034 14.1 0.0 0.87 9.6 0.2 2.5 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.9 AIC16106.1 - 0.039 12.4 0.1 0.22 9.9 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_9 PF13454.1 AIC16106.1 - 0.041 13.6 0.1 0.3 10.8 0.0 2.2 2 0 0 2 2 2 0 FAD-NAD(P)-binding Trp_halogenase PF04820.9 AIC16106.1 - 0.097 11.2 0.0 0.19 10.3 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase adh_short PF00106.20 AIC16108.1 - 2.7e-39 134.7 2.0 3.7e-39 134.3 1.4 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.1 AIC16108.1 - 2.4e-20 73.3 1.2 3.1e-20 72.9 0.8 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.5 AIC16108.1 - 4.4e-15 55.8 0.8 6.5e-15 55.2 0.5 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.1 AIC16108.1 - 2.7e-05 24.2 3.9 0.00016 21.7 2.7 1.9 1 1 0 1 1 1 1 NADH(P)-binding DUF1776 PF08643.5 AIC16108.1 - 8.1e-05 21.8 0.0 0.0001 21.5 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.16 AIC16108.1 - 0.00018 21.0 0.3 0.0017 17.8 0.2 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Eno-Rase_NADH_b PF12242.3 AIC16108.1 - 0.00023 20.8 4.0 0.00067 19.3 2.8 1.8 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase THF_DHG_CYH_C PF02882.14 AIC16108.1 - 0.0077 15.3 2.0 0.029 13.4 0.1 2.5 2 1 0 3 3 3 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CTP_transf_1 PF01148.15 AIC16110.1 - 6.1e-14 52.2 16.1 2.9e-12 46.8 5.3 2.4 1 1 0 2 2 2 2 Cytidylyltransferase family Frizzled PF01534.12 AIC16110.1 - 0.074 11.8 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region ABC_membrane PF00664.18 AIC16110.1 - 2.8 7.2 8.1 1.4 8.2 0.4 2.7 2 1 0 3 3 3 0 ABC transporter transmembrane region DUF1440 PF07274.7 AIC16112.1 - 0.028 14.4 5.0 0.027 14.4 2.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1440) YqhR PF11085.3 AIC16112.1 - 0.18 11.3 7.6 0.58 9.6 5.3 1.9 1 1 0 1 1 1 0 Conserved membrane protein YqhR HAP PF03866.8 AIC16112.1 - 1.2 8.8 10.1 0.29 10.9 2.5 2.1 1 1 0 2 2 2 0 Hydrophobic abundant protein (HAP) DUF3816 PF12822.2 AIC16112.1 - 3.7 7.4 19.7 11 5.8 13.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) DUF2953 PF11167.3 AIC16112.1 - 5.4 7.0 9.9 16 5.4 0.1 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2953) IncA PF04156.9 AIC16113.1 - 0.31 10.6 1.9 0.36 10.4 1.3 1.2 1 0 0 1 1 1 0 IncA protein FA_desaturase PF00487.19 AIC16113.1 - 0.69 9.3 3.9 0.84 9.0 2.7 1.0 1 0 0 1 1 1 0 Fatty acid desaturase YlaH PF14036.1 AIC16113.1 - 0.78 9.8 5.4 1 9.4 3.8 1.2 1 0 0 1 1 1 0 YlaH-like protein Gln-synt_C PF00120.19 AIC16115.1 - 1.2e-88 296.6 0.0 1.5e-88 296.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.14 AIC16115.1 - 8.6e-24 82.9 0.0 1.9e-23 81.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain AA_synth PF06684.6 AIC16115.1 - 0.098 12.0 0.0 0.17 11.2 0.0 1.3 1 0 0 1 1 1 0 Amino acid synthesis NuiA PF07924.6 AIC16116.1 - 0.067 13.0 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein PTS-HPr PF00381.14 AIC16116.1 - 0.094 12.6 0.2 0.29 11.0 0.1 1.9 2 0 0 2 2 2 0 PTS HPr component phosphorylation site Rotamase_3 PF13616.1 AIC16118.1 - 3.8e-28 98.0 0.0 4.3e-28 97.9 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.16 AIC16118.1 - 9.9e-28 96.7 0.0 1.2e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.1 AIC16118.1 - 5.4e-11 43.1 0.0 6.1e-11 43.0 0.0 1.0 1 0 0 1 1 1 1 PPIC-type PPIASE domain PapD_C PF02753.12 AIC16118.1 - 0.1 12.4 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Pili assembly chaperone PapD, C-terminal domain Cupredoxin_1 PF13473.1 AIC16119.1 - 4.2e-07 29.7 0.0 3.2e-06 26.9 0.0 2.3 2 0 0 2 2 2 1 Cupredoxin-like domain Copper-bind PF00127.15 AIC16119.1 - 0.00045 20.3 0.0 0.0015 18.7 0.0 1.9 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family A2M_N PF01835.14 AIC16119.1 - 0.023 14.9 0.0 0.14 12.3 0.0 2.3 3 0 0 3 3 3 0 MG2 domain SIMPL PF04402.9 AIC16121.1 - 2.4e-45 154.9 8.8 3e-45 154.6 6.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF1657 PF07870.6 AIC16121.1 - 0.012 15.2 0.2 0.035 13.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1657) CAP_N PF01213.14 AIC16121.1 - 0.028 13.6 1.9 0.049 12.9 1.3 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal HD_4 PF13328.1 AIC16122.1 - 2.1e-21 76.2 7.8 2.7e-21 75.9 5.4 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.17 AIC16122.1 - 2e-07 31.0 2.8 3.3e-07 30.3 0.8 2.1 2 0 0 2 2 2 1 HD domain DMAP_binding PF06464.6 AIC16122.1 - 0.46 11.0 3.3 0.38 11.3 1.1 1.6 2 0 0 2 2 2 0 DMAP1-binding Domain DnaJ PF00226.26 AIC16124.1 - 9.2e-25 86.1 1.3 1.7e-24 85.3 0.9 1.5 1 0 0 1 1 1 1 DnaJ domain Fer4_15 PF13459.1 AIC16124.1 - 1.2e-09 38.5 0.2 3.3e-09 37.1 0.2 1.8 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_13 PF13370.1 AIC16124.1 - 4.3e-07 30.2 0.2 4.3e-07 30.2 0.1 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_19 PF06902.6 AIC16124.1 - 1.2e-06 28.2 0.1 2.8e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Divergent 4Fe-4S mono-cluster OrfB_IS605 PF01385.14 AIC16125.1 - 1e-26 93.7 3.6 1.8e-26 92.9 2.5 1.4 1 0 0 1 1 1 1 Probable transposase OrfB_Zn_ribbon PF07282.6 AIC16125.1 - 3.4e-13 49.0 1.2 9.3e-13 47.6 0.8 1.8 1 0 0 1 1 1 1 Putative transposase DNA-binding domain HTH_OrfB_IS605 PF12323.3 AIC16125.1 - 1.8e-12 46.3 0.7 4.7e-12 45.0 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain DZR PF12773.2 AIC16125.1 - 0.037 13.8 0.8 0.087 12.6 0.5 1.7 1 0 0 1 1 1 0 Double zinc ribbon HypA PF01155.14 AIC16125.1 - 0.058 13.0 0.2 0.058 13.0 0.1 1.6 2 0 0 2 2 2 0 Hydrogenase expression/synthesis hypA family FYVE PF01363.16 AIC16125.1 - 0.075 12.9 1.6 0.2 11.5 0.1 2.2 2 0 0 2 2 2 0 FYVE zinc finger zf-ribbon_3 PF13248.1 AIC16125.1 - 0.094 11.9 1.9 0.73 9.1 0.2 2.2 1 1 1 2 2 2 0 zinc-ribbon domain TP_methylase PF00590.15 AIC16126.1 - 6.5e-47 159.9 0.1 7.8e-47 159.6 0.1 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Radical_SAM PF04055.16 AIC16126.1 - 0.092 12.9 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily TP_methylase PF00590.15 AIC16127.1 - 3.5e-44 151.0 0.6 4.9e-44 150.5 0.4 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases FtsX PF02687.16 AIC16130.1 - 0.039 13.7 4.1 0.048 13.4 2.8 1.1 1 0 0 1 1 1 0 FtsX-like permease family Acyl_transf_3 PF01757.17 AIC16130.1 - 0.14 10.9 2.2 0.14 10.9 1.5 1.0 1 0 0 1 1 1 0 Acyltransferase family Abhydrolase_9_N PF15420.1 AIC16130.1 - 0.34 10.6 2.6 0.35 10.6 1.8 1.0 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus SPC12 PF06645.8 AIC16130.1 - 2.4 8.0 6.8 88 3.0 4.7 2.1 1 1 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Snf7 PF03357.16 AIC16131.1 - 0.028 13.7 5.8 0.05 12.9 4.0 1.5 1 1 0 1 1 1 0 Snf7 Big_3_4 PF13754.1 AIC16132.1 - 0.014 15.7 0.5 0.014 15.7 0.4 3.2 4 0 0 4 4 4 0 Bacterial Ig-like domain (group 3) Ovate PF04844.8 AIC16137.1 - 0.094 12.5 0.1 0.12 12.1 0.1 1.1 1 0 0 1 1 1 0 Transcriptional repressor, ovate DUF3944 PF13099.1 AIC16137.1 - 0.14 11.7 0.7 0.32 10.5 0.2 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3944) Polysacc_deac_1 PF01522.16 AIC16138.1 - 2.9e-11 43.0 0.0 4.1e-11 42.5 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Asp_Glu_race PF01177.17 AIC16141.1 - 1.2e-28 100.5 0.0 1.6e-28 100.1 0.0 1.2 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase rve_3 PF13683.1 AIC16142.1 - 4e-06 26.2 0.0 5.3e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DUF2384 PF09722.5 AIC16142.1 - 0.042 13.7 0.0 0.068 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2384) rve_3 PF13683.1 AIC16144.1 - 4.1e-08 32.6 0.0 7.7e-08 31.7 0.0 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.1 AIC16144.1 - 0.0002 21.3 0.2 0.00023 21.1 0.1 1.2 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16144.1 - 0.016 15.3 0.1 0.025 14.6 0.1 1.3 1 0 0 1 1 1 0 Integrase core domain 7TMR-DISM_7TM PF07695.6 AIC16145.1 - 0.015 14.9 9.7 0.022 14.4 6.8 1.2 1 0 0 1 1 1 0 7TM diverse intracellular signalling DUF2463 PF09591.5 AIC16145.1 - 0.33 10.5 7.4 0.49 9.9 5.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2463) SdpI PF13630.1 AIC16145.1 - 0.38 10.4 9.7 0.1 12.3 0.6 2.4 1 1 1 2 2 2 0 SdpI/YhfL protein family DUF998 PF06197.8 AIC16145.1 - 1.6 8.0 8.4 16 4.7 5.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF998) NfeD PF01957.13 AIC16145.1 - 3.5 7.7 5.6 5 7.2 0.4 2.2 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding DUF3784 PF12650.2 AIC16145.1 - 4.9 7.1 9.6 5.5 7.0 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3784) Prenyltransf PF01255.14 AIC16148.1 - 7.6e-76 254.1 0.9 9e-76 253.8 0.7 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Nucleo_P87 PF07267.6 AIC16149.1 - 9 4.8 7.6 13 4.2 5.3 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ish1 PF10281.4 AIC16150.1 - 0.048 13.7 0.1 0.07 13.2 0.1 1.3 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein zinc_ribbon_2 PF13240.1 AIC16151.1 - 8e-08 31.5 4.1 1.3e-07 30.8 2.9 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC16151.1 - 2.8e-07 29.5 2.6 4.7e-07 28.8 1.8 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 AIC16151.1 - 5.3e-05 22.9 2.1 9.2e-05 22.1 1.4 1.4 1 0 0 1 1 1 1 Double zinc ribbon ASFV_p27 PF06556.6 AIC16151.1 - 0.0003 20.7 0.3 0.00072 19.4 0.1 1.6 2 0 0 2 2 2 1 IAP-like protein p27 C-terminus UPF0547 PF10571.4 AIC16151.1 - 0.0033 17.0 3.4 0.0057 16.3 2.3 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 Cript PF10235.4 AIC16151.1 - 0.0089 16.3 0.1 0.017 15.4 0.1 1.5 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT zf-DHHC PF01529.15 AIC16151.1 - 0.022 14.1 0.4 0.038 13.3 0.3 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF2116 PF09889.4 AIC16151.1 - 0.043 13.6 1.4 0.079 12.7 1.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) RRN7 PF11781.3 AIC16151.1 - 0.1 12.1 3.9 3 7.4 0.6 2.4 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 Nudix_N_2 PF14803.1 AIC16151.1 - 0.55 9.9 5.2 5.7 6.7 0.7 2.4 2 0 0 2 2 2 0 Nudix N-terminal DUF4149 PF13664.1 AIC16152.1 - 0.035 14.1 1.1 0.035 14.1 0.8 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) DUF2269 PF10027.4 AIC16152.1 - 0.11 12.2 6.7 0.015 15.0 1.9 1.6 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2269) DUF3746 PF12562.3 AIC16153.1 - 0.091 12.6 0.5 0.15 11.9 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3746) DUF4624 PF15417.1 AIC16154.1 - 0.084 12.4 0.1 0.1 12.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4624) COBRA1 PF06209.8 AIC16154.1 - 0.1 11.1 0.0 0.12 10.9 0.0 1.0 1 0 0 1 1 1 0 Cofactor of BRCA1 (COBRA1) Na_H_Exchanger PF00999.16 AIC16155.1 - 9.7e-60 202.0 51.8 1.2e-59 201.8 35.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family UPF0542 PF15086.1 AIC16155.1 - 0.13 12.0 0.0 0.47 10.1 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Pro_CA PF00484.14 AIC16156.1 - 0.06 13.3 0.3 0.094 12.7 0.2 1.4 1 0 0 1 1 1 0 Carbonic anhydrase PS_Dcarbxylase PF02666.10 AIC16156.1 - 0.076 12.2 0.1 0.1 11.8 0.1 1.2 1 0 0 1 1 1 0 Phosphatidylserine decarboxylase Tcp10_C PF07202.8 AIC16156.1 - 0.083 12.4 0.1 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 T-complex protein 10 C-terminus Glyco_hydro_14 PF01373.12 AIC16156.1 - 0.14 10.9 0.1 0.18 10.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 ADH_zinc_N PF00107.21 AIC16157.1 - 5.8e-33 113.2 0.2 9.5e-33 112.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AIC16157.1 - 7.4e-25 86.8 0.0 1.3e-24 86.0 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 AIC16157.1 - 9.1e-14 52.4 0.0 1.7e-13 51.5 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.13 AIC16157.1 - 0.035 14.0 0.1 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_16 PF10294.4 AIC16157.1 - 0.12 11.7 0.1 0.18 11.2 0.1 1.2 1 0 0 1 1 1 0 Putative methyltransferase DUF165 PF02592.10 AIC16159.1 - 0.021 14.9 0.2 0.039 14.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized ACR, YhhQ family COG1738 DUF3198 PF11433.3 AIC16159.1 - 0.026 14.4 0.3 0.22 11.4 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3198) Cloacin_immun PF03513.9 AIC16159.1 - 0.029 14.3 0.1 0.15 12.1 0.0 2.2 2 1 0 2 2 2 0 Cloacin immunity protein HicB PF05534.7 AIC16159.1 - 0.056 13.0 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 HicB family DUF2985 PF11204.3 AIC16159.1 - 0.12 12.1 0.4 0.42 10.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) TerC PF03741.11 AIC16160.1 - 1.1e-51 174.9 16.2 1.1e-51 174.9 11.2 2.1 2 0 0 2 2 2 1 Integral membrane protein TerC family zf-C2H2_4 PF13894.1 AIC16161.1 - 1.9e-06 27.7 0.8 2.3e-06 27.5 0.6 1.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-Di19 PF05605.7 AIC16161.1 - 8.6e-05 22.5 0.2 0.0001 22.3 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.21 AIC16161.1 - 0.00016 21.8 0.9 0.00019 21.5 0.7 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_2 PF12756.2 AIC16161.1 - 0.0012 18.8 0.1 0.0012 18.8 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) DUF2225 PF09986.4 AIC16161.1 - 0.019 14.4 0.0 0.019 14.4 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-CHCC PF10276.4 AIC16161.1 - 0.026 14.3 0.2 0.033 14.0 0.1 1.2 1 0 0 1 1 1 0 Zinc-finger domain zf-H2C2_2 PF13465.1 AIC16161.1 - 0.032 14.5 3.5 1 9.8 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger double domain DUF629 PF04780.7 AIC16161.1 - 0.056 11.9 0.1 0.06 11.8 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-RING_3 PF14369.1 AIC16161.1 - 0.069 13.1 0.1 0.099 12.6 0.0 1.3 1 0 0 1 1 1 0 zinc-finger zf-C2H2_jaz PF12171.3 AIC16161.1 - 0.12 12.5 0.2 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF2555 PF10742.4 AIC16162.1 - 0.024 14.2 0.1 0.038 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) DUF72 PF01904.13 AIC16164.1 - 0.00042 20.1 0.1 0.00042 20.1 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 PepSY PF03413.14 AIC16166.1 - 1.6e-07 31.8 2.8 1.7e-05 25.3 0.2 2.2 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain Transposase_31 PF04754.7 AIC16166.1 - 0.00072 18.9 0.0 0.0012 18.2 0.0 1.3 1 0 0 1 1 1 1 Putative transposase, YhgA-like PepSY_2 PF13670.1 AIC16166.1 - 0.0038 17.0 0.0 0.89 9.5 0.0 2.2 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain Flagellin_D3 PF08884.6 AIC16166.1 - 1.7 8.8 7.4 1.1 9.5 1.7 2.6 1 1 1 2 2 2 0 Flagellin D3 domain zf-RING_3 PF14369.1 AIC16168.1 - 0.017 15.0 1.8 0.019 14.9 0.4 1.8 2 0 0 2 2 2 0 zinc-finger DUF4242 PF14026.1 AIC16169.1 - 8.3e-13 48.2 0.0 9.4e-13 48.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4242) AmoC PF04896.7 AIC16170.1 - 1.5e-16 60.2 4.4 1.8e-16 59.9 3.0 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C OAD_gamma PF04277.8 AIC16170.1 - 0.28 11.5 1.9 1.7 9.0 0.0 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain HicB PF05534.7 AIC16171.1 - 0.0012 18.3 0.2 0.0021 17.6 0.1 1.4 1 0 0 1 1 1 1 HicB family RHH_1 PF01402.16 AIC16171.1 - 0.0071 16.1 0.1 0.02 14.8 0.1 1.7 2 0 0 2 2 2 1 Ribbon-helix-helix protein, copG family HTH_20 PF12840.2 AIC16172.1 - 3.4e-11 42.7 0.7 6.4e-11 41.8 0.3 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC16172.1 - 1e-07 31.4 0.3 1.8e-07 30.7 0.2 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 AIC16172.1 - 2.7e-07 29.8 0.0 5.5e-07 28.8 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC16172.1 - 3.4e-05 23.4 0.4 5.9e-05 22.6 0.3 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC16172.1 - 0.0018 17.9 0.1 0.0047 16.5 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.7 AIC16172.1 - 0.044 13.6 0.0 0.065 13.0 0.0 1.4 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC Sigma70_r4 PF04545.11 AIC16172.1 - 0.054 12.8 0.2 0.72 9.2 0.0 2.7 3 0 0 3 3 3 0 Sigma-70, region 4 V4R PF02830.13 AIC16174.1 - 6.1e-09 35.5 1.4 1e-08 34.8 1.0 1.4 1 0 0 1 1 1 1 V4R domain RHH_1 PF01402.16 AIC16175.1 - 6.4e-05 22.6 0.2 0.00021 21.0 0.1 1.9 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family RHH_3 PF12651.2 AIC16175.1 - 0.0057 16.3 0.4 0.012 15.3 0.3 1.5 1 0 0 1 1 1 1 Ribbon-helix-helix domain HicB PF05534.7 AIC16175.1 - 0.018 14.5 0.1 0.048 13.2 0.0 1.8 2 0 0 2 2 2 0 HicB family RHH_4 PF13467.1 AIC16175.1 - 0.071 13.0 0.1 0.36 10.7 0.0 2.1 2 0 0 2 2 2 0 Ribbon-helix-helix domain HTH_40 PF14493.1 AIC16175.1 - 0.082 13.1 0.6 0.15 12.2 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HisKA_3 PF07730.8 AIC16177.1 - 0.0011 19.3 8.2 0.17 12.2 0.0 4.0 1 1 1 2 2 2 1 Histidine kinase DUF2088 PF09861.4 AIC16177.1 - 0.25 10.3 3.1 0.14 11.1 0.5 1.7 1 1 0 2 2 2 0 Domain of unknown function (DUF2088) Prominin PF05478.6 AIC16177.1 - 0.63 7.4 9.3 2.4 5.6 2.4 2.0 1 1 0 2 2 2 0 Prominin OMS28_porin PF03532.8 AIC16177.1 - 0.8 8.7 13.0 1 8.3 9.0 1.1 1 0 0 1 1 1 0 OMS28 porin Fibritin_C PF07921.7 AIC16177.1 - 1.1 9.2 9.0 1.1 9.2 2.6 2.8 1 1 2 3 3 3 0 Fibritin C-terminal region DUF4259 PF14078.1 AIC16177.1 - 4.3 7.8 6.8 7.9 6.9 2.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4259) DUF2203 PF09969.4 AIC16177.1 - 4.8 7.4 13.4 0.25 11.5 0.9 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF4131 PF13567.1 AIC16178.1 - 0.0021 17.5 0.4 0.0025 17.2 0.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) SbmA_BacA PF05992.7 AIC16178.1 - 0.016 14.3 0.7 0.017 14.2 0.5 1.0 1 0 0 1 1 1 0 SbmA/BacA-like family DUF4282 PF14110.1 AIC16178.1 - 0.05 13.7 2.0 0.058 13.5 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) Fzo_mitofusin PF04799.8 AIC16178.1 - 0.23 10.8 0.9 0.23 10.7 0.6 1.1 1 0 0 1 1 1 0 fzo-like conserved region DUF4190 PF13828.1 AIC16178.1 - 4.7 6.8 6.8 13 5.4 4.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4190) LIM PF00412.17 AIC16180.1 - 1.2e-05 25.2 1.8 2.2e-05 24.4 1.3 1.5 1 1 0 1 1 1 1 LIM domain DUF2296 PF10058.4 AIC16180.1 - 0.023 14.4 1.0 0.023 14.4 0.7 1.5 2 0 0 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) zf-dskA_traR PF01258.12 AIC16180.1 - 0.043 13.5 3.9 9.7 6.0 0.0 3.1 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger zf-HC5HC2H_2 PF13832.1 AIC16180.1 - 0.061 13.3 3.6 0.099 12.6 2.5 1.4 1 1 0 1 1 1 0 PHD-zinc-finger like domain zinc_ribbon_2 PF13240.1 AIC16180.1 - 0.12 11.8 5.6 1 8.9 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain C1_1 PF00130.17 AIC16180.1 - 0.14 11.9 8.2 0.45 10.2 1.1 2.6 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RRN7 PF11781.3 AIC16180.1 - 0.21 11.1 3.6 4.3 6.9 0.0 3.0 3 0 0 3 3 3 0 RNA polymerase I-specific transcription initiation factor Rrn7 Endonuclease_7 PF02945.10 AIC16180.1 - 0.25 11.0 3.7 0.11 12.2 1.1 1.5 1 1 1 2 2 2 0 Recombination endonuclease VII zf-LYAR PF08790.6 AIC16180.1 - 0.27 10.9 1.8 6.4 6.5 0.0 2.4 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger XPA_N PF01286.13 AIC16180.1 - 0.37 10.4 3.2 8.5 6.1 0.0 3.0 3 0 0 3 3 3 0 XPA protein N-terminal Prok-RING_1 PF14446.1 AIC16180.1 - 0.41 10.4 9.6 7.7 6.3 3.5 3.1 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 Vps39_2 PF10367.4 AIC16180.1 - 0.41 10.8 0.1 0.41 10.8 0.1 2.2 3 0 0 3 3 2 0 Vacuolar sorting protein 39 domain 2 zf-ribbon_3 PF13248.1 AIC16180.1 - 0.44 9.8 9.9 20 4.5 0.2 3.0 2 1 0 2 2 2 0 zinc-ribbon domain Lar_restr_allev PF14354.1 AIC16180.1 - 0.6 10.4 5.6 11 6.4 3.9 2.2 1 1 0 1 1 1 0 Restriction alleviation protein Lar DZR PF12773.2 AIC16180.1 - 0.7 9.7 7.1 21 5.0 4.9 2.5 1 1 0 1 1 1 0 Double zinc ribbon DUF1272 PF06906.6 AIC16180.1 - 1 9.2 6.3 4.1 7.3 0.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) DUF678 PF05077.7 AIC16180.1 - 1.1 9.2 8.0 0.13 12.2 1.8 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF678) Sgf11 PF08209.6 AIC16180.1 - 1.7 7.9 5.6 10 5.5 0.0 3.1 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zinc_ribbon_4 PF13717.1 AIC16180.1 - 1.9 8.2 5.7 8.7 6.1 0.0 3.0 3 0 0 3 3 3 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.7 AIC16180.1 - 2.1 7.7 6.9 6.8 6.0 0.1 2.7 3 0 0 3 3 3 0 TFIIB zinc-binding YhfH PF14149.1 AIC16180.1 - 2.8 7.8 0.0 2.8 7.8 0.0 3.0 4 0 0 4 4 4 0 YhfH-like protein zinc_ribbon_5 PF13719.1 AIC16180.1 - 3.9 7.1 7.2 8.4 6.0 0.0 3.0 3 0 0 3 3 3 0 zinc-ribbon domain Yippee-Mis18 PF03226.9 AIC16180.1 - 4.6 7.3 8.9 0.93 9.5 2.6 2.3 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DNA_RNApol_7kD PF03604.8 AIC16180.1 - 6.6 6.2 7.8 5.4 6.5 0.2 3.0 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-RanBP PF00641.13 AIC16180.1 - 8.4 5.5 12.3 2.1 7.5 0.7 3.1 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others Prim_Zn_Ribbon PF08273.7 AIC16180.1 - 9.1 6.4 6.7 39 4.4 2.4 2.8 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase HicB PF05534.7 AIC16183.1 - 0.0022 17.5 0.0 0.0039 16.7 0.0 1.4 1 0 0 1 1 1 1 HicB family DUF892 PF05974.7 AIC16183.1 - 0.0028 17.4 0.4 0.068 12.9 0.1 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF892) RNR_N PF08343.5 AIC16183.1 - 0.0039 16.9 0.0 0.008 15.9 0.0 1.5 1 0 0 1 1 1 1 Ribonucleotide reductase N-terminal Arc PF03869.9 AIC16183.1 - 0.008 15.7 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 Arc-like DNA binding domain Cu-oxidase_3 PF07732.10 AIC16184.1 - 3.9e-24 84.6 6.6 7.5e-23 80.5 0.1 3.1 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 AIC16184.1 - 1.1e-15 57.3 10.9 3.6e-06 26.5 0.0 3.9 4 0 0 4 4 4 3 Multicopper oxidase Cupredoxin_1 PF13473.1 AIC16184.1 - 5.9e-13 48.6 0.0 1.7e-09 37.5 0.1 3.5 4 1 0 4 4 4 2 Cupredoxin-like domain Copper-bind PF00127.15 AIC16184.1 - 1e-11 44.9 5.0 2.4e-08 34.1 0.4 3.6 2 1 1 3 3 3 2 Copper binding proteins, plastocyanin/azurin family PKD PF00801.15 AIC16184.1 - 0.001 18.7 0.4 0.0038 16.9 0.3 2.0 1 0 0 1 1 1 1 PKD domain Cu-oxidase PF00394.17 AIC16184.1 - 0.0074 16.2 0.2 0.71 9.7 0.0 3.1 3 0 0 3 3 3 1 Multicopper oxidase DUF4398 PF14346.1 AIC16185.1 - 0.0072 16.3 1.3 0.014 15.4 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4398) DUF2524 PF10732.4 AIC16185.1 - 0.2 11.8 3.6 0.33 11.0 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2524) DUF3306 PF11748.3 AIC16186.1 - 0.019 15.5 0.3 0.049 14.2 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3306) DUF2296 PF10058.4 AIC16186.1 - 0.36 10.6 1.8 1.5 8.5 1.3 1.9 1 1 1 2 2 2 0 Predicted integral membrane metal-binding protein (DUF2296) zf-C2H2_2 PF12756.2 AIC16186.1 - 2.2 8.4 4.3 2.1 8.4 0.3 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) p450 PF00067.17 AIC16187.1 - 6.5e-35 120.5 0.1 1.4e-32 112.8 0.1 3.0 1 1 0 1 1 1 1 Cytochrome P450 Fer4_7 PF12838.2 AIC16189.1 - 8.8e-10 38.8 27.2 2.8e-06 27.6 6.8 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.22 AIC16189.1 - 1.7e-09 36.8 12.2 2e-06 27.1 1.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.1 AIC16189.1 - 5.3e-09 35.9 0.7 0.0013 18.7 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.1 AIC16189.1 - 6e-08 32.8 5.9 1.5e-07 31.5 4.1 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.2 AIC16189.1 - 1.8e-07 30.6 10.5 0.0015 18.3 1.1 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_6 PF12837.2 AIC16189.1 - 2.2e-07 30.4 12.2 0.0013 18.5 2.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.1 AIC16189.1 - 4.9e-07 29.4 20.1 1.3e-05 24.9 6.8 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 AIC16189.1 - 2.4e-06 27.8 11.5 2.6e-05 24.4 4.0 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 AIC16189.1 - 2.7e-06 27.1 7.0 0.00013 21.7 4.9 2.2 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_4 PF12800.2 AIC16189.1 - 1.3e-05 25.0 6.3 0.034 14.4 1.2 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.1 AIC16189.1 - 1.5e-05 25.6 6.0 0.0044 17.7 0.5 2.5 3 0 0 3 3 2 2 4Fe-4S double cluster binding domain Fer4_13 PF13370.1 AIC16189.1 - 5.7e-05 23.4 8.0 0.016 15.6 0.3 2.8 3 0 0 3 3 3 2 4Fe-4S single cluster domain Fer4_18 PF13746.1 AIC16189.1 - 8.2e-05 22.9 9.7 0.0002 21.6 5.0 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_15 PF13459.1 AIC16189.1 - 9.8e-05 22.8 10.7 0.021 15.3 1.5 2.9 3 1 0 3 3 3 2 4Fe-4S single cluster domain Fer4_11 PF13247.1 AIC16189.1 - 0.0067 16.2 1.2 2.7 7.9 0.0 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.2 AIC16189.1 - 0.029 14.9 15.4 0.13 12.9 0.9 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain AsnC_trans_reg PF01037.16 AIC16191.1 - 4.8e-06 26.1 0.0 5e-06 26.1 0.0 1.0 1 0 0 1 1 1 1 AsnC family DZR PF12773.2 AIC16193.1 - 0.00034 20.3 9.2 0.0015 18.2 6.4 1.8 1 1 0 1 1 1 1 Double zinc ribbon Ribosomal_S27 PF01599.14 AIC16193.1 - 0.062 13.1 0.7 0.062 13.1 0.5 2.3 2 1 0 2 2 2 0 Ribosomal protein S27a DUF3133 PF11331.3 AIC16193.1 - 0.17 11.4 0.1 0.17 11.4 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3133) Ribosomal_L37e PF01907.14 AIC16193.1 - 0.24 11.2 15.2 0.86 9.4 1.1 2.4 1 1 1 2 2 2 0 Ribosomal protein L37e zf-C2H2 PF00096.21 AIC16193.1 - 0.96 9.9 0.1 0.96 9.9 0.0 3.5 2 1 1 3 3 3 0 Zinc finger, C2H2 type zf-dskA_traR PF01258.12 AIC16193.1 - 2.4 7.9 7.7 22 4.9 0.1 3.3 3 0 0 3 3 3 0 Prokaryotic dksA/traR C4-type zinc finger zf-ribbon_3 PF13248.1 AIC16193.1 - 2.8 7.2 11.9 6 6.2 1.8 2.6 2 1 0 2 2 2 0 zinc-ribbon domain DnaJ_CXXCXGXG PF00684.14 AIC16193.1 - 2.9 7.9 13.6 83 3.3 10.0 2.3 1 1 1 2 2 2 0 DnaJ central domain Papo_T_antigen PF02380.10 AIC16193.1 - 4 7.4 6.6 2 8.3 3.2 1.6 1 1 1 2 2 2 0 T-antigen specific domain Polyketide_cyc2 PF10604.4 AIC16196.1 - 4.2e-12 46.4 0.0 4.8e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 AIC16196.1 - 1.5e-05 24.9 0.0 3e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport RCC_reductase PF06405.6 AIC16197.1 - 0.029 13.3 0.0 0.036 13.0 0.0 1.1 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) HTH_45 PF14947.1 AIC16201.1 - 2.6e-17 62.4 0.5 3.3e-17 62.0 0.3 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix Spatacsin_C PF14649.1 AIC16201.1 - 0.072 11.9 0.1 0.085 11.7 0.0 1.2 1 0 0 1 1 1 0 Spatacsin C-terminus DnaI_N PF07319.6 AIC16203.1 - 0.0035 17.5 0.1 0.0042 17.2 0.0 1.1 1 0 0 1 1 1 1 Primosomal protein DnaI N-terminus Augurin PF15187.1 AIC16203.1 - 0.049 13.5 0.0 0.059 13.2 0.0 1.2 1 0 0 1 1 1 0 Oesophageal cancer-related gene 4 CPSase_L_D2 PF02786.12 AIC16203.1 - 0.094 11.9 0.1 0.11 11.7 0.0 1.0 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain SEN1_N PF12726.2 AIC16203.1 - 0.1 10.6 0.0 0.12 10.4 0.0 1.0 1 0 0 1 1 1 0 SEN1 N terminal Rubis-subs-bind PF09273.6 AIC16203.1 - 0.12 12.3 0.1 0.17 11.7 0.1 1.3 1 1 0 1 1 1 0 Rubisco LSMT substrate-binding DUF2922 PF11148.3 AIC16204.1 - 0.0078 15.8 0.2 0.022 14.3 0.2 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) CHB_HEX_C PF03174.8 AIC16206.1 - 4.9e-34 116.0 24.4 4e-20 71.4 6.2 5.3 5 0 0 5 5 5 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 AIC16206.1 - 2.5e-28 97.9 21.6 9.1e-17 60.9 4.4 5.4 5 0 0 5 5 5 2 Fn3 associated CHB_HEX_C_1 PF13290.1 AIC16206.1 - 3.4e-28 97.1 23.9 9e-18 63.8 6.3 6.3 7 0 0 7 7 7 2 Chitobiase/beta-hexosaminidase C-terminal domain Polysacc_deac_1 PF01522.16 AIC16206.1 - 5.9e-09 35.6 0.0 1.5e-08 34.3 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide deacetylase HYR PF02494.11 AIC16206.1 - 5.1e-08 32.8 1.6 5.1e-08 32.8 1.1 5.3 5 1 1 6 6 6 1 HYR domain Y_Y_Y PF07495.8 AIC16206.1 - 3.8e-07 29.7 0.0 0.017 14.8 0.0 2.9 2 0 0 2 2 2 2 Y_Y_Y domain Big_3_4 PF13754.1 AIC16206.1 - 5.2e-05 23.4 15.1 0.00027 21.1 4.7 6.5 5 2 2 7 7 7 3 Bacterial Ig-like domain (group 3) CARDB PF07705.6 AIC16206.1 - 0.014 15.4 0.9 0.014 15.4 0.6 2.7 2 1 0 2 2 2 0 CARDB Endonuc_Holl PF10107.4 AIC16206.1 - 0.12 12.0 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase PepSY PF03413.14 AIC16207.1 - 0.0031 18.1 0.2 0.0054 17.3 0.1 1.3 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain DUF3761 PF12587.3 AIC16207.1 - 0.075 13.1 0.3 0.14 12.2 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3761) RskA PF10099.4 AIC16207.1 - 0.12 12.1 2.3 0.2 11.4 0.7 1.8 2 0 0 2 2 2 0 Anti-sigma-K factor rskA SNARE_assoc PF09335.6 AIC16209.1 - 1.3e-17 64.1 1.9 1.3e-17 64.1 1.3 1.4 2 0 0 2 2 2 1 SNARE associated Golgi protein Pam17 PF08566.5 AIC16209.1 - 0.072 12.7 0.1 0.096 12.3 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial import protein Pam17 HTH_45 PF14947.1 AIC16210.1 - 1.6e-20 72.6 0.3 1.9e-20 72.4 0.2 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix ER PF01133.12 AIC16210.1 - 0.0081 15.8 0.0 0.0087 15.7 0.0 1.2 1 0 0 1 1 1 1 Enhancer of rudimentary DUF4364 PF14277.1 AIC16210.1 - 0.026 14.1 0.1 0.04 13.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) AsnC_trans_reg PF01037.16 AIC16211.1 - 1.3e-07 31.1 0.0 1.4e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 AsnC family Cpn60_TCP1 PF00118.19 AIC16213.1 - 0.0003 19.5 0.0 0.0003 19.5 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family eIF-1a PF01176.14 AIC16214.1 - 7.4e-22 76.5 1.0 9.7e-22 76.1 0.7 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.14 AIC16214.1 - 0.0078 15.8 1.1 0.034 13.8 0.2 2.2 2 1 0 2 2 2 1 Myosin N-terminal SH3-like domain DUF1314 PF07013.6 AIC16214.1 - 0.089 12.1 0.0 0.12 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) MMR_HSR1 PF01926.18 AIC16215.1 - 8.1e-18 64.4 0.4 1.7e-17 63.4 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_N PF13167.1 AIC16215.1 - 1.3e-13 50.8 0.2 6.4e-13 48.6 0.0 2.2 3 0 0 3 3 3 1 GTP-binding GTPase N-terminal FeoB_N PF02421.13 AIC16215.1 - 5.8e-08 32.1 1.5 6.4e-08 32.0 0.2 1.7 2 0 0 2 2 2 1 Ferrous iron transport protein B GTP_EFTU PF00009.22 AIC16215.1 - 1.2e-06 28.1 0.7 1.6e-05 24.4 0.5 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain PduV-EutP PF10662.4 AIC16215.1 - 4.7e-05 22.9 0.9 0.00047 19.6 0.7 2.4 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation SRPRB PF09439.5 AIC16215.1 - 6.1e-05 22.3 0.6 0.0001 21.5 0.4 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.22 AIC16215.1 - 0.00012 22.3 0.7 0.00066 19.9 0.1 2.5 1 1 1 2 2 2 1 ABC transporter DUF258 PF03193.11 AIC16215.1 - 0.00097 18.3 0.2 0.0024 17.0 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF258 Dynamin_N PF00350.18 AIC16215.1 - 0.0016 18.2 2.2 0.01 15.6 1.5 2.2 1 1 0 1 1 1 1 Dynamin family cobW PF02492.14 AIC16215.1 - 0.011 15.2 5.0 0.46 9.9 0.2 2.6 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain AAA_33 PF13671.1 AIC16215.1 - 0.013 15.3 0.0 0.35 10.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain Miro PF08477.8 AIC16215.1 - 0.023 15.1 0.5 0.093 13.2 0.1 2.2 2 1 0 2 2 2 0 Miro-like protein AAA_14 PF13173.1 AIC16215.1 - 0.061 13.2 0.2 0.25 11.2 0.2 2.1 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.1 AIC16215.1 - 0.083 13.1 2.5 7.7 6.8 0.0 2.6 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.1 AIC16215.1 - 0.09 12.3 0.2 0.26 10.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3787 PF12655.2 AIC16215.1 - 0.13 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3787) MobB PF03205.9 AIC16215.1 - 0.15 11.7 2.1 0.3 10.7 0.2 2.3 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B zf-C2H2_6 PF13912.1 AIC16216.1 - 0.063 13.2 1.8 0.19 11.6 0.0 2.3 2 1 0 2 2 2 0 C2H2-type zinc finger zinc_ribbon_5 PF13719.1 AIC16216.1 - 0.08 12.5 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain DUF866 PF05907.8 AIC16216.1 - 0.097 12.1 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) zinc_ribbon_4 PF13717.1 AIC16216.1 - 0.12 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 zinc-ribbon domain TFIIB PF00382.14 AIC16217.1 - 2e-30 104.3 6.3 1.2e-15 57.0 0.2 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 AIC16217.1 - 6.8e-07 28.5 3.8 1.4e-06 27.5 2.6 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_11 PF08279.7 AIC16217.1 - 1.7e-05 24.4 1.5 8.9e-05 22.0 0.1 2.5 3 0 0 3 3 3 1 HTH domain HTH_24 PF13412.1 AIC16217.1 - 0.00012 21.3 0.3 0.0018 17.5 0.0 2.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC16217.1 - 0.002 17.6 0.0 0.017 14.6 0.0 2.5 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain Cyclin_N PF00134.18 AIC16217.1 - 0.0023 17.5 0.1 1 8.9 0.0 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain HTH_3 PF01381.17 AIC16217.1 - 0.0057 16.4 0.1 0.032 14.0 0.0 2.3 3 0 0 3 3 3 1 Helix-turn-helix Sigma70_r4 PF04545.11 AIC16217.1 - 0.0059 15.8 0.0 0.13 11.6 0.0 2.5 2 1 0 2 2 2 1 Sigma-70, region 4 TetR_N PF00440.18 AIC16217.1 - 0.021 14.4 0.0 0.13 11.9 0.0 2.1 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Rrf2 PF02082.15 AIC16217.1 - 0.049 13.7 1.3 2.6 8.2 0.0 2.9 3 0 0 3 3 3 0 Transcriptional regulator HTH_23 PF13384.1 AIC16217.1 - 0.053 13.1 0.0 0.27 10.9 0.0 2.2 2 0 0 2 2 2 0 Homeodomain-like domain HARE-HTH PF05066.8 AIC16217.1 - 0.058 13.7 1.0 3.1 8.1 0.0 2.5 2 0 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain Sigma70_r4_2 PF08281.7 AIC16217.1 - 0.086 12.3 2.6 3.3 7.2 0.0 3.0 3 0 0 3 3 3 0 Sigma-70, region 4 RB_B PF01857.15 AIC16217.1 - 0.093 12.2 0.1 0.17 11.3 0.1 1.5 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain HrcA_DNA-bdg PF03444.10 AIC16217.1 - 0.22 10.9 2.9 0.56 9.6 0.0 2.8 4 0 0 4 4 4 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding DUF948 PF06103.6 AIC16221.1 - 0.0013 18.5 0.4 0.0015 18.3 0.3 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Myosin_tail_1 PF01576.14 AIC16221.1 - 0.0041 14.9 0.9 0.0045 14.7 0.6 1.0 1 0 0 1 1 1 1 Myosin tail BLOC1_2 PF10046.4 AIC16221.1 - 0.0045 17.1 1.4 0.0054 16.8 1.0 1.1 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 HWE_HK PF07536.9 AIC16221.1 - 0.005 17.2 0.1 0.0061 16.9 0.1 1.1 1 0 0 1 1 1 1 HWE histidine kinase Seryl_tRNA_N PF02403.17 AIC16221.1 - 0.0056 16.6 1.6 0.007 16.3 1.1 1.1 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Hpt PF01627.18 AIC16221.1 - 0.0081 16.1 0.1 0.011 15.7 0.1 1.3 1 1 0 1 1 1 1 Hpt domain Nup54 PF13874.1 AIC16221.1 - 0.0095 15.6 0.6 0.01 15.5 0.4 1.0 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 DUF745 PF05335.8 AIC16221.1 - 0.01 15.3 0.3 0.011 15.3 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF745) ECM11 PF15463.1 AIC16221.1 - 0.013 15.8 0.5 0.015 15.6 0.4 1.2 1 0 0 1 1 1 0 Extracellular mutant protein 11 Lebercilin PF15619.1 AIC16221.1 - 0.017 14.5 1.7 0.02 14.3 1.2 1.0 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease PspB PF06667.7 AIC16221.1 - 0.017 15.0 1.1 0.02 14.7 0.7 1.2 1 0 0 1 1 1 0 Phage shock protein B DUF1759 PF03564.10 AIC16221.1 - 0.02 14.6 0.7 0.023 14.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Laminin_II PF06009.7 AIC16221.1 - 0.022 14.4 0.9 0.025 14.3 0.6 1.0 1 0 0 1 1 1 0 Laminin Domain II AF0941-like PF14591.1 AIC16221.1 - 0.025 14.6 0.5 0.026 14.5 0.4 1.0 1 0 0 1 1 1 0 AF0941-like TBPIP PF07106.8 AIC16221.1 - 0.028 13.9 2.3 0.028 13.9 1.6 1.1 1 0 0 1 1 1 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) DUF4446 PF14584.1 AIC16221.1 - 0.041 13.7 0.4 0.041 13.7 0.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Cep57_MT_bd PF06657.8 AIC16221.1 - 0.057 13.3 1.4 0.09 12.7 0.8 1.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Snapin_Pallidin PF14712.1 AIC16221.1 - 0.06 13.6 0.7 0.21 11.9 0.1 1.7 1 1 1 2 2 2 0 Snapin/Pallidin DUF1319 PF07028.6 AIC16221.1 - 0.06 13.5 1.5 0.06 13.5 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1319) DUF1664 PF07889.7 AIC16221.1 - 0.072 12.8 0.7 0.12 12.1 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Occludin_ELL PF07303.8 AIC16221.1 - 0.082 13.6 0.7 0.089 13.5 0.5 1.0 1 0 0 1 1 1 0 Occludin homology domain Nup88 PF10168.4 AIC16221.1 - 0.1 10.4 1.1 0.11 10.3 0.7 1.0 1 0 0 1 1 1 0 Nuclear pore component P4Ha_N PF08336.6 AIC16221.1 - 0.11 12.3 1.3 0.13 12.0 0.9 1.1 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region DUF972 PF06156.8 AIC16221.1 - 0.21 11.9 1.8 0.37 11.1 1.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF972) MutS_IV PF05190.13 AIC16221.1 - 0.87 9.8 3.3 8.8 6.5 2.3 2.0 1 1 0 1 1 1 0 MutS family domain IV bZIP_1 PF00170.16 AIC16221.1 - 0.95 9.4 4.3 3.5 7.6 0.5 2.0 1 1 1 2 2 2 0 bZIP transcription factor Guanylate_cyc PF00211.15 AIC16225.1 - 3.7e-18 65.5 0.1 4.7e-17 61.9 0.0 2.1 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PGK PF00162.14 AIC16225.1 - 0.024 13.2 0.1 0.036 12.6 0.1 1.3 1 0 0 1 1 1 0 Phosphoglycerate kinase Terminase_5 PF06056.7 AIC16225.1 - 0.065 12.7 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Radical_SAM PF04055.16 AIC16226.1 - 3.8e-10 40.1 0.3 2.3e-09 37.6 0.1 2.1 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 AIC16226.1 - 1.9e-06 27.8 0.1 4.1e-06 26.8 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 AIC16226.1 - 2.1e-06 27.9 0.1 4.6e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain GCR1_C PF12550.3 AIC16228.1 - 0.0081 16.0 0.7 0.011 15.5 0.5 1.3 1 0 0 1 1 1 1 Transcriptional activator of glycolytic enzymes AAA PF00004.24 AIC16229.1 - 6.7e-98 324.0 0.0 2.8e-49 166.6 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 AIC16229.1 - 3.2e-25 87.8 0.1 9.9e-25 86.3 0.1 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.7 AIC16229.1 - 4.5e-17 61.8 0.0 5.2e-11 42.0 0.0 2.9 3 0 0 3 3 3 2 Holliday junction DNA helicase ruvB N-terminus AAA_2 PF07724.9 AIC16229.1 - 1.5e-16 60.7 0.0 5.4e-07 29.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 AIC16229.1 - 8.9e-14 51.8 0.1 2.2e-05 24.5 0.0 3.3 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.1 AIC16229.1 - 2.1e-13 50.5 0.3 8.3e-05 22.7 0.0 4.1 2 2 0 2 2 2 2 AAA domain AAA_5 PF07728.9 AIC16229.1 - 5.4e-13 48.8 1.1 2.5e-06 27.2 0.1 4.2 4 2 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_17 PF13207.1 AIC16229.1 - 7.3e-12 46.1 0.2 3.3e-05 24.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.1 AIC16229.1 - 2.6e-11 43.5 0.0 7.5e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 AIC16229.1 - 4.7e-10 38.8 0.0 0.0002 20.5 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin TIP49 PF06068.8 AIC16229.1 - 1.6e-09 37.0 0.2 0.00066 18.4 0.0 2.5 2 0 0 2 2 2 2 TIP49 C-terminus AAA_33 PF13671.1 AIC16229.1 - 1.2e-08 34.9 0.0 0.0028 17.5 0.0 2.6 2 0 0 2 2 2 2 AAA domain Arch_ATPase PF01637.13 AIC16229.1 - 3.1e-08 33.6 0.1 0.00079 19.1 0.0 3.6 2 2 1 3 3 3 2 Archaeal ATPase IstB_IS21 PF01695.12 AIC16229.1 - 4.1e-08 32.8 0.4 0.0025 17.2 0.1 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Sigma54_activat PF00158.21 AIC16229.1 - 1.9e-07 30.7 0.1 0.07 12.6 0.1 3.8 3 1 0 3 3 3 2 Sigma-54 interaction domain RNA_helicase PF00910.17 AIC16229.1 - 2.1e-07 31.0 0.0 0.016 15.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase CDC48_2 PF02933.12 AIC16229.1 - 3.8e-07 29.6 0.1 1.1e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_18 PF13238.1 AIC16229.1 - 7.7e-07 29.4 0.0 0.028 14.7 0.0 3.1 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AIC16229.1 - 8.1e-07 28.7 2.2 0.0043 16.7 0.1 2.9 3 0 0 3 3 2 2 Part of AAA domain AAA_25 PF13481.1 AIC16229.1 - 1.3e-06 27.9 5.9 0.8 9.0 0.1 4.3 2 2 1 4 4 4 2 AAA domain AAA_24 PF13479.1 AIC16229.1 - 2.1e-06 27.4 0.2 0.039 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain KaiC PF06745.8 AIC16229.1 - 3.4e-06 26.3 1.5 0.17 10.9 0.0 3.4 2 1 1 3 3 3 2 KaiC AAA_28 PF13521.1 AIC16229.1 - 4e-06 26.8 0.0 0.12 12.3 0.0 2.7 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.13 AIC16229.1 - 5e-06 26.3 0.2 0.17 11.5 0.0 3.7 2 2 2 4 4 3 2 Bacterial dnaA protein Mg_chelatase PF01078.16 AIC16229.1 - 6.7e-06 25.4 0.4 0.048 12.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI PhoH PF02562.11 AIC16229.1 - 1e-05 24.8 0.6 0.073 12.2 0.1 2.6 2 0 0 2 2 2 2 PhoH-like protein Sigma54_activ_2 PF14532.1 AIC16229.1 - 2e-05 24.6 0.0 0.14 12.2 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain NACHT PF05729.7 AIC16229.1 - 2.1e-05 24.2 0.1 0.81 9.3 0.0 3.8 3 1 0 4 4 4 2 NACHT domain ABC_tran PF00005.22 AIC16229.1 - 4.4e-05 23.7 0.0 0.4 10.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter DUF815 PF05673.8 AIC16229.1 - 4.5e-05 22.5 0.0 0.12 11.3 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) NB-ARC PF00931.17 AIC16229.1 - 0.00022 20.1 0.0 0.3 9.9 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain NTPase_1 PF03266.10 AIC16229.1 - 0.00046 19.9 1.1 6.1 6.5 0.0 4.0 2 1 1 3 3 3 0 NTPase AAA_3 PF07726.6 AIC16229.1 - 0.00079 19.0 0.0 0.18 11.4 0.0 2.6 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.4 AIC16229.1 - 0.0013 17.7 0.0 0.66 8.8 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.9 AIC16229.1 - 0.0029 16.6 0.0 1.1 8.1 0.0 3.2 2 2 1 3 3 3 1 KAP family P-loop domain T2SE PF00437.15 AIC16229.1 - 0.0031 16.4 0.0 1.6 7.5 0.0 2.5 2 0 0 2 2 2 1 Type II/IV secretion system protein UPF0079 PF02367.12 AIC16229.1 - 0.0034 17.0 0.1 2.4 7.7 0.0 2.5 2 0 0 2 2 2 1 Uncharacterised P-loop hydrolase UPF0079 Parvo_NS1 PF01057.12 AIC16229.1 - 0.0052 15.6 0.1 2 7.2 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 Guanylate_kin PF00625.16 AIC16229.1 - 0.0061 16.0 0.2 1.7 8.0 0.0 3.4 2 1 1 3 3 3 1 Guanylate kinase SKI PF01202.17 AIC16229.1 - 0.0064 16.3 0.0 1.6 8.5 0.0 2.5 2 0 0 2 2 2 1 Shikimate kinase AAA_30 PF13604.1 AIC16229.1 - 0.012 15.1 0.5 4.3 6.8 0.0 2.7 3 0 0 3 3 2 0 AAA domain ResIII PF04851.10 AIC16229.1 - 0.018 14.8 0.0 6.3 6.5 0.0 2.5 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit ATP-synt_ab PF00006.20 AIC16229.1 - 0.027 13.9 0.1 4.6 6.6 0.0 2.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain PduV-EutP PF10662.4 AIC16229.1 - 0.045 13.2 0.0 4.9 6.6 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CPT PF07931.7 AIC16229.1 - 0.046 13.3 0.0 7.1 6.2 0.0 2.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein DUF258 PF03193.11 AIC16229.1 - 0.051 12.7 0.0 3.5 6.7 0.0 2.6 3 0 0 3 3 2 0 Protein of unknown function, DUF258 SRPRB PF09439.5 AIC16229.1 - 0.071 12.3 0.0 11 5.1 0.0 2.5 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AFG1_ATPase PF03969.11 AIC16229.1 - 0.1 11.3 0.0 8.5 5.0 0.0 2.6 3 0 0 3 3 2 0 AFG1-like ATPase AAA_29 PF13555.1 AIC16229.1 - 0.1 12.1 0.4 12 5.5 0.1 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain DAP3 PF10236.4 AIC16229.1 - 0.11 11.4 0.0 5.3 5.8 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 DUF927 PF06048.6 AIC16229.1 - 0.12 11.6 0.0 1.2 8.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF927) IPT PF01745.11 AIC16229.1 - 0.13 11.4 0.3 13 4.8 0.1 2.5 2 0 0 2 2 2 0 Isopentenyl transferase AAA_11 PF13086.1 AIC16229.1 - 0.13 11.8 0.0 1.1 8.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain PIF1 PF05970.9 AIC16229.1 - 0.18 10.7 0.0 12 4.7 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase AAA_21 PF13304.1 AIC16229.1 - 0.18 11.7 2.0 5.1 6.9 0.0 3.3 3 1 0 3 3 2 0 AAA domain AAA_10 PF12846.2 AIC16229.1 - 1.9 7.8 4.6 21 4.4 0.3 3.5 4 1 0 4 4 2 0 AAA-like domain ABC2_membrane PF01061.19 AIC16230.1 - 2.4e-37 128.1 17.9 2.4e-37 128.1 12.4 1.3 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 AIC16230.1 - 2.1e-16 59.8 25.9 2.7e-16 59.5 18.0 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 AIC16230.1 - 3e-10 39.4 21.7 9.1e-10 37.8 15.1 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.2 AIC16230.1 - 4.9e-07 29.1 16.1 6.4e-07 28.7 11.2 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF3814 PF12769.2 AIC16230.1 - 0.25 11.5 13.1 2.8 8.1 0.4 4.3 1 1 2 4 4 4 0 Domain of unknown function (DUF3814) ABC_tran PF00005.22 AIC16231.1 - 1.1e-30 106.6 0.2 5.9e-30 104.3 0.0 2.3 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.1 AIC16231.1 - 1.5e-14 54.6 0.6 9.9e-11 42.1 0.0 2.6 2 1 0 3 3 3 2 AAA domain AAA_15 PF13175.1 AIC16231.1 - 1.4e-07 30.8 0.0 8.7e-06 25.0 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain DUF4162 PF13732.1 AIC16231.1 - 4.1e-05 23.9 0.0 0.00014 22.2 0.0 2.0 2 0 0 2 2 1 1 Domain of unknown function (DUF4162) AAA PF00004.24 AIC16231.1 - 0.0089 16.2 0.4 0.049 13.8 0.3 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.14 AIC16231.1 - 0.014 14.5 0.4 3.9 6.6 0.1 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 AIC16231.1 - 0.021 14.9 0.1 0.11 12.6 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.1 AIC16231.1 - 0.04 14.2 0.3 0.04 14.2 0.2 2.6 2 1 0 3 3 3 0 AAA domain AAA_16 PF13191.1 AIC16231.1 - 0.044 13.7 0.0 0.087 12.8 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.1 AIC16231.1 - 0.053 13.1 0.4 0.2 11.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_10 PF12846.2 AIC16231.1 - 0.086 12.2 0.6 0.35 10.2 0.3 2.0 1 1 1 2 2 2 0 AAA-like domain AAA_25 PF13481.1 AIC16231.1 - 0.12 11.8 0.8 5.9 6.2 0.6 2.5 1 1 0 1 1 1 0 AAA domain zf-C2H2_jaz PF12171.3 AIC16232.1 - 2.1e-05 24.4 0.1 3.2e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.1 AIC16232.1 - 9.6e-05 22.1 0.0 0.00012 21.8 0.0 1.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC16232.1 - 0.00037 20.6 0.2 0.00053 20.1 0.1 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-met PF12874.2 AIC16232.1 - 0.0031 17.6 0.0 0.007 16.5 0.0 1.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.1 AIC16232.1 - 0.021 15.1 0.1 0.031 14.5 0.1 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger zf-LYAR PF08790.6 AIC16232.1 - 0.044 13.4 0.0 0.076 12.7 0.0 1.5 1 0 0 1 1 1 0 LYAR-type C2HC zinc finger zf-H2C2_2 PF13465.1 AIC16232.1 - 0.058 13.7 1.6 0.19 12.0 0.2 2.1 2 0 0 2 2 2 0 Zinc-finger double domain DUF3215 PF11503.3 AIC16234.1 - 0.033 13.8 0.1 0.055 13.1 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3215) Methyltransf_26 PF13659.1 AIC16236.1 - 0.00015 21.7 0.0 0.00051 20.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC16236.1 - 0.01 16.4 0.2 0.034 14.7 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain AsnC_trans_reg PF01037.16 AIC16237.1 - 6.3e-08 32.2 0.0 7.5e-08 31.9 0.0 1.1 1 0 0 1 1 1 1 AsnC family NapD PF03927.8 AIC16237.1 - 0.0034 17.1 0.0 0.0089 15.8 0.0 1.5 1 1 0 1 1 1 1 NapD protein DUF1034 PF06280.7 AIC16238.1 - 0.57 10.5 5.5 17 5.8 1.3 3.3 1 1 1 2 2 2 0 Fn3-like domain (DUF1034) HTH_45 PF14947.1 AIC16240.1 - 1.5e-12 47.1 1.3 1.7e-12 46.9 0.9 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC16240.1 - 0.0021 17.6 0.1 0.0023 17.5 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_27 PF13463.1 AIC16240.1 - 0.0047 17.2 0.1 0.0062 16.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain ER PF01133.12 AIC16240.1 - 0.0053 16.4 0.0 0.006 16.2 0.0 1.1 1 0 0 1 1 1 1 Enhancer of rudimentary Acetyltransf_13 PF13880.1 AIC16240.1 - 0.0087 15.7 0.1 0.33 10.7 0.0 2.1 1 1 0 2 2 2 1 ESCO1/2 acetyl-transferase DUF4423 PF14394.1 AIC16240.1 - 0.047 13.2 0.0 0.05 13.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) DUF2397 PF09660.5 AIC16240.1 - 0.11 11.0 0.1 0.15 10.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) DUF63 PF01889.12 AIC16241.1 - 0.056 13.5 3.5 0.06 13.4 2.4 1.0 1 0 0 1 1 1 0 Membrane protein of unknown function DUF63 DUF4149 PF13664.1 AIC16241.1 - 0.095 12.7 4.9 0.14 12.2 3.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) Pox_A21 PF05323.7 AIC16241.1 - 0.13 12.7 0.3 0.18 12.2 0.2 1.3 1 0 0 1 1 1 0 Poxvirus A21 Protein DUF4131 PF13567.1 AIC16241.1 - 0.4 10.0 5.3 0.077 12.4 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) NfeD PF01957.13 AIC16241.1 - 4 7.5 5.9 0.58 10.2 0.2 1.9 1 1 1 2 2 2 0 NfeD-like C-terminal, partner-binding DUF2795 PF11387.3 AIC16242.1 - 2.7e-08 33.5 0.1 1.4e-07 31.2 0.1 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF2795) DEK_C PF08766.6 AIC16242.1 - 0.05 13.3 0.2 0.81 9.5 0.0 2.4 2 0 0 2 2 2 0 DEK C terminal domain Phage_integrase PF00589.17 AIC16243.1 - 5.4e-05 22.9 0.1 0.001 18.8 0.1 2.5 1 1 0 1 1 1 1 Phage integrase family HTH_38 PF13936.1 AIC16243.1 - 0.0003 20.2 1.1 0.00076 18.9 0.1 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.1 AIC16243.1 - 0.02 14.2 0.0 0.045 13.1 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Cpn60_TCP1 PF00118.19 AIC16246.1 - 1.8e-155 518.3 11.4 2e-155 518.1 7.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3574 PF12098.3 AIC16247.1 - 0.00019 20.9 0.0 0.00021 20.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3574) Usp PF00582.21 AIC16248.1 - 1.2e-31 109.8 0.2 1.4e-31 109.5 0.1 1.1 1 0 0 1 1 1 1 Universal stress protein family bact-PGI_C PF10432.4 AIC16248.1 - 0.015 15.0 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal region ETF PF01012.16 AIC16248.1 - 0.043 13.5 0.1 0.11 12.2 0.0 1.6 2 0 0 2 2 2 0 Electron transfer flavoprotein domain Activator-TraM PF11657.3 AIC16249.1 - 0.00047 19.6 0.3 0.00048 19.6 0.2 1.0 1 0 0 1 1 1 1 Transcriptional activator TraM Herpes_U34 PF04541.8 AIC16251.1 - 0.031 13.2 0.0 0.034 13.0 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus virion protein U34 CCDC14 PF15254.1 AIC16251.1 - 0.052 11.9 0.0 0.056 11.8 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 YodA PF09223.6 AIC16251.1 - 0.072 12.7 0.0 0.083 12.5 0.0 1.1 1 0 0 1 1 1 0 YodA lipocalin-like domain TFIIB PF00382.14 AIC16252.1 - 2e-21 75.5 1.9 2.4e-11 43.2 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.7 AIC16252.1 - 4.1e-08 32.4 0.1 7.3e-08 31.6 0.1 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_24 PF13412.1 AIC16252.1 - 0.00022 20.5 0.3 0.12 11.7 0.0 3.3 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC16252.1 - 0.00028 20.3 0.3 0.62 9.6 0.1 3.3 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.7 AIC16252.1 - 0.0012 18.4 1.3 0.022 14.3 0.0 3.0 4 0 0 4 4 4 1 HTH domain HTH_3 PF01381.17 AIC16252.1 - 0.0025 17.6 0.0 1.8 8.4 0.0 2.6 2 0 0 2 2 2 2 Helix-turn-helix HTH_10 PF04967.7 AIC16252.1 - 0.0033 16.9 0.4 5.5 6.6 0.0 3.2 3 0 0 3 3 3 2 HTH DNA binding domain GntR PF00392.16 AIC16252.1 - 0.0072 15.7 0.1 1.1 8.7 0.0 2.8 3 0 0 3 3 3 1 Bacterial regulatory proteins, gntR family Rrf2 PF02082.15 AIC16252.1 - 0.01 15.9 0.0 6.8 6.8 0.0 2.8 3 0 0 3 3 3 0 Transcriptional regulator HTH_Crp_2 PF13545.1 AIC16252.1 - 0.013 15.2 0.1 0.23 11.2 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_Mga PF08280.6 AIC16252.1 - 0.017 14.8 0.2 3.8 7.3 0.0 3.6 4 0 0 4 4 4 0 M protein trans-acting positive regulator (MGA) HTH domain DUF746 PF05344.6 AIC16252.1 - 0.18 11.3 1.0 13 5.4 0.0 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF746) HTH_23 PF13384.1 AIC16252.1 - 0.85 9.3 6.3 1.1 9.0 0.0 3.4 4 0 0 4 4 3 0 Homeodomain-like domain Abhydrolase_5 PF12695.2 AIC16253.1 - 2.2e-19 69.6 0.1 3.1e-19 69.1 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.2 AIC16253.1 - 4e-12 46.4 0.6 2.4e-05 24.3 0.8 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family DLH PF01738.13 AIC16253.1 - 8.2e-11 41.5 0.0 1.1e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.16 AIC16253.1 - 2.7e-08 33.3 0.5 3.9e-05 22.9 0.0 2.7 2 1 1 3 3 3 2 Prolyl oligopeptidase family BAAT_C PF08840.6 AIC16253.1 - 9.9e-06 25.4 0.0 0.016 14.9 0.0 2.1 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.13 AIC16253.1 - 2.8e-05 23.7 0.1 0.018 14.4 0.0 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.15 AIC16253.1 - 0.0098 15.4 0.3 2.2 7.7 0.2 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.11 AIC16253.1 - 0.03 13.7 0.0 0.88 8.9 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase zf-C2H2 PF00096.21 AIC16255.1 - 0.00011 22.2 0.7 0.00011 22.2 0.5 2.0 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-met PF12874.2 AIC16255.1 - 0.00031 20.8 1.1 0.00031 20.8 0.8 1.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.3 AIC16255.1 - 0.002 18.1 1.4 0.002 18.1 1.0 1.8 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.1 AIC16255.1 - 0.0026 17.9 2.1 0.0065 16.7 0.1 2.1 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.1 AIC16255.1 - 0.0055 16.9 0.4 0.0055 16.9 0.3 2.0 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_2 PF12756.2 AIC16255.1 - 0.052 13.6 1.8 0.059 13.4 1.2 1.2 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-BED PF02892.10 AIC16255.1 - 0.067 12.9 0.6 0.096 12.4 0.4 1.4 1 1 0 1 1 1 0 BED zinc finger zf-met2 PF12907.2 AIC16255.1 - 0.089 12.7 1.8 0.12 12.3 1.2 1.2 1 0 0 1 1 1 0 Zinc-binding TAT_signal PF10518.4 AIC16256.1 - 0.0023 17.7 0.1 0.0037 17.1 0.1 1.3 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.4 AIC16256.1 - 0.04 13.0 2.9 0.12 11.5 2.0 1.7 1 1 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DDE_Tnp_IS240 PF13610.1 AIC16257.1 - 8.9e-10 38.6 0.0 1.4e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16257.1 - 2.3e-05 24.4 0.2 4.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC16257.1 - 0.00017 20.8 0.6 0.00033 19.9 0.3 1.6 1 1 0 1 1 1 1 Transposase IS66 family DUF4206 PF13901.1 AIC16257.1 - 0.029 13.9 0.7 0.04 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) Rieske PF00355.21 AIC16258.1 - 7.2e-09 35.1 0.0 9.3e-09 34.7 0.0 1.2 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain EcoRII-C PF09019.6 AIC16259.1 - 0.047 13.5 0.2 0.052 13.3 0.1 1.1 1 0 0 1 1 1 0 EcoRII C terminal DUF3388 PF11868.3 AIC16259.1 - 0.057 12.5 0.2 0.088 11.9 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3388) DUF3490 PF11995.3 AIC16259.1 - 0.06 12.9 1.2 0.059 12.9 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) Ferritin_2 PF13668.1 AIC16259.1 - 0.076 12.9 0.2 0.1 12.5 0.2 1.4 1 1 0 1 1 1 0 Ferritin-like domain EssA PF10661.4 AIC16260.1 - 0.078 12.6 1.4 0.093 12.3 1.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA TarH PF02203.10 AIC16261.1 - 0.00062 19.6 0.0 0.00077 19.3 0.0 1.0 1 0 0 1 1 1 1 Tar ligand binding domain homologue DUF4131 PF13567.1 AIC16261.1 - 0.022 14.1 0.2 0.029 13.7 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4525 PF15027.1 AIC16261.1 - 0.26 10.8 1.0 7.6 6.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4525) Cupredoxin_1 PF13473.1 AIC16262.1 - 2.2e-06 27.4 0.0 5.1e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 AIC16262.1 - 0.00017 21.7 0.0 0.00035 20.7 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cu-oxidase_3 PF07732.10 AIC16262.1 - 0.006 16.3 0.0 1.8 8.3 0.0 2.6 2 0 0 2 2 2 2 Multicopper oxidase Mer2 PF09074.5 AIC16263.1 - 0.025 14.5 0.2 0.031 14.1 0.2 1.1 1 0 0 1 1 1 0 Mer2 DUF2096 PF09869.4 AIC16263.1 - 0.025 14.4 0.6 0.042 13.7 0.1 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) DUF1672 PF07901.6 AIC16263.1 - 0.026 13.5 0.3 0.028 13.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Muted PF14942.1 AIC16263.1 - 0.034 14.0 0.2 0.043 13.7 0.1 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein SLX9 PF15341.1 AIC16263.1 - 0.052 13.9 2.0 0.065 13.6 1.4 1.2 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 DUF1743 PF08489.6 AIC16263.1 - 0.076 12.7 0.1 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1743) Terminase_2 PF03592.11 AIC16263.1 - 0.52 10.5 5.3 0.14 12.4 1.8 1.5 2 0 0 2 2 2 0 Terminase small subunit PD40 PF07676.7 AIC16265.1 - 5.7e-10 38.6 4.2 0.0029 17.2 0.3 4.6 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat DPPIV_N PF00930.16 AIC16265.1 - 5.6e-07 28.4 0.0 1.5e-05 23.8 0.0 2.4 1 1 1 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9_N PF02897.10 AIC16265.1 - 6e-06 25.1 0.2 0.013 14.0 0.0 2.6 3 0 0 3 3 3 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Pectate_lyase22 PF14583.1 AIC16265.1 - 0.00065 18.2 0.1 0.036 12.5 0.0 2.6 1 1 0 2 2 2 1 Oligogalacturonate lyase Lactonase PF10282.4 AIC16265.1 - 0.013 14.6 0.3 0.15 11.1 0.0 2.4 1 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller PPC PF04151.10 AIC16265.1 - 0.053 14.5 2.0 0.053 14.5 1.4 3.6 2 2 1 3 3 3 0 Bacterial pre-peptidase C-terminal domain DUF3015 PF11220.3 AIC16266.1 - 0.16 11.5 1.3 0.28 10.7 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3015) DUF3552 PF12072.3 AIC16268.1 - 0.12 11.5 0.2 0.15 11.2 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) MS_channel PF00924.13 AIC16269.1 - 4e-12 45.9 8.8 4e-12 45.9 6.1 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel Alg14 PF08660.6 AIC16269.1 - 0.02 14.9 0.8 0.055 13.4 0.4 1.8 2 0 0 2 2 2 0 Oligosaccharide biosynthesis protein Alg14 like DUF1212 PF06738.7 AIC16269.1 - 0.19 11.1 7.5 0.22 10.9 4.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1212) DUF21 PF01595.15 AIC16269.1 - 8.5 5.6 14.5 0.91 8.7 5.9 2.0 1 1 1 2 2 2 0 Domain of unknown function DUF21 Guanylate_cyc PF00211.15 AIC16270.1 - 6.6e-16 58.1 0.0 8.7e-16 57.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain YiaAB PF05360.9 AIC16272.1 - 5.9 6.5 8.6 1.4 8.5 0.5 2.1 2 0 0 2 2 2 0 yiaA/B two helix domain Tetraspannin PF00335.15 AIC16272.1 - 6.1 6.0 7.2 14 4.8 4.9 1.6 1 1 0 1 1 1 0 Tetraspanin family Peptidase_M48 PF01435.13 AIC16273.1 - 2.3e-37 128.7 0.1 4.6e-37 127.7 0.1 1.5 1 1 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.6 AIC16273.1 - 3.3e-08 32.8 0.1 6.8e-07 28.5 0.0 2.0 2 0 0 2 2 2 1 BlaR1 peptidase M56 Peptidase_MA_2 PF13485.1 AIC16273.1 - 0.066 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Peptidase MA superfamily HemY_N PF07219.8 AIC16273.1 - 6.2 6.4 7.1 0.59 9.7 0.2 2.4 2 0 0 2 2 2 0 HemY protein N-terminus HTH_45 PF14947.1 AIC16274.1 - 1.1e-15 57.1 0.0 1.5e-15 56.7 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix UNC119_bdg PF15435.1 AIC16274.1 - 0.053 12.8 0.2 0.13 11.5 0.0 1.6 2 0 0 2 2 2 0 UNC119-binding protein C5orf30 homologue Ferritin PF00210.19 AIC16275.1 - 2.5e-19 69.4 0.0 3.2e-19 69.0 0.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.12 AIC16275.1 - 0.01 16.1 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 0 Rubrerythrin Rieske PF00355.21 AIC16276.1 - 4.7e-14 51.7 0.2 6.2e-14 51.3 0.1 1.2 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 AIC16276.1 - 0.0025 17.5 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain NAD_synthase PF02540.12 AIC16278.1 - 5.4e-78 261.2 0.0 6.2e-78 261.0 0.0 1.0 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.16 AIC16278.1 - 1.4e-06 28.0 0.0 2.1e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.11 AIC16278.1 - 4.8e-06 25.3 0.0 0.00017 20.2 0.0 2.5 3 0 0 3 3 3 1 tRNA methyl transferase HTH_23 PF13384.1 AIC16278.1 - 0.00051 19.5 0.1 0.0055 16.3 0.0 2.5 2 0 0 2 2 2 1 Homeodomain-like domain QueC PF06508.8 AIC16278.1 - 0.0081 15.4 0.0 0.016 14.5 0.0 1.5 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Sigma70_r4 PF04545.11 AIC16278.1 - 0.038 13.2 0.0 0.12 11.6 0.0 1.9 1 1 0 1 1 1 0 Sigma-70, region 4 HTH_28 PF13518.1 AIC16278.1 - 0.044 13.7 0.0 0.29 11.1 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain AP_endonuc_2 PF01261.19 AIC16279.1 - 2.5e-05 23.6 0.0 0.00011 21.5 0.0 2.0 2 1 0 2 2 2 1 Xylose isomerase-like TIM barrel PsbP PF01789.11 AIC16280.1 - 0.031 13.7 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 PsbP adh_short PF00106.20 AIC16283.1 - 7.1e-21 74.8 2.8 7.1e-21 74.8 1.9 1.7 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.5 AIC16283.1 - 1.6e-10 40.9 1.5 2.8e-10 40.1 1.0 1.4 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.1 AIC16283.1 - 5.9e-09 36.0 0.1 2e-08 34.3 0.1 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.16 AIC16283.1 - 1.3e-05 24.8 0.2 2e-05 24.1 0.0 1.4 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.1 AIC16283.1 - 0.016 15.1 4.2 0.049 13.6 1.7 2.5 2 2 0 2 2 2 0 NADH(P)-binding 3HCDH_N PF02737.13 AIC16283.1 - 0.034 13.7 0.1 0.061 12.9 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 AIC16283.1 - 0.037 13.1 0.3 0.071 12.2 0.2 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Eno-Rase_NADH_b PF12242.3 AIC16283.1 - 0.047 13.4 0.5 0.15 11.8 0.1 2.1 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase AdoHcyase_NAD PF00670.16 AIC16283.1 - 0.059 13.2 0.5 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain THF_DHG_CYH_C PF02882.14 AIC16283.1 - 0.076 12.0 0.2 0.14 11.2 0.1 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ribonuc_red_lgC PF02867.10 AIC16284.1 - 1.7e-156 521.9 0.0 4.1e-156 520.6 0.0 1.7 1 1 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.16 AIC16284.1 - 2e-31 107.6 0.0 6.8e-31 105.9 0.0 2.0 1 1 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.11 AIC16284.1 - 9.1e-19 67.6 0.3 3e-18 66.0 0.2 2.0 1 0 0 1 1 1 1 ATP cone domain zf-ribbon_3 PF13248.1 AIC16284.1 - 0.34 10.1 2.7 0.68 9.2 1.9 1.5 1 0 0 1 1 1 0 zinc-ribbon domain NRDD PF13597.1 AIC16285.1 - 9.1e-17 60.3 0.0 6e-16 57.6 0.0 2.0 2 0 0 2 2 2 1 Anaerobic ribonucleoside-triphosphate reductase ATP-cone PF03477.11 AIC16285.1 - 1.3e-09 38.3 0.2 4.7e-09 36.5 0.2 2.0 1 0 0 1 1 1 1 ATP cone domain HTH_20 PF12840.2 AIC16285.1 - 2.9e-09 36.5 0.0 1.3e-08 34.5 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain Snf7 PF03357.16 AIC16286.1 - 7.3e-06 25.4 4.1 1.4e-05 24.5 2.8 1.4 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.9 AIC16286.1 - 0.057 12.8 0.1 0.091 12.1 0.1 1.3 1 0 0 1 1 1 0 Regulator of Vps4 activity in the MVB pathway DASH_Dad2 PF08654.5 AIC16286.1 - 0.39 10.7 2.8 0.35 10.8 0.4 2.4 2 1 0 2 2 2 0 DASH complex subunit Dad2 Lebercilin PF15619.1 AIC16286.1 - 0.63 9.4 4.6 0.11 11.8 0.6 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TF_Zn_Ribbon PF08271.7 AIC16287.1 - 2.2e-05 23.6 0.3 0.018 14.3 0.1 2.1 2 0 0 2 2 2 2 TFIIB zinc-binding zf-ribbon_3 PF13248.1 AIC16287.1 - 0.00062 18.8 2.4 0.074 12.2 0.2 2.1 2 0 0 2 2 2 2 zinc-ribbon domain zf-NADH-PPase PF09297.6 AIC16287.1 - 0.0015 18.0 1.2 0.21 11.1 0.0 2.2 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain DZR PF12773.2 AIC16287.1 - 0.0026 17.5 0.4 0.0066 16.2 0.3 1.6 1 1 0 1 1 1 1 Double zinc ribbon Rad50_zn_hook PF04423.9 AIC16287.1 - 0.003 16.9 0.1 0.0051 16.2 0.1 1.5 1 1 0 1 1 1 1 Rad50 zinc hook motif Prok-RING_1 PF14446.1 AIC16287.1 - 0.0035 17.0 0.6 0.43 10.3 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 zinc_ribbon_2 PF13240.1 AIC16287.1 - 0.0042 16.5 0.4 0.53 9.8 0.0 2.1 2 0 0 2 2 2 1 zinc-ribbon domain zf-4CXXC_R1 PF10497.4 AIC16287.1 - 0.0088 16.1 0.3 0.0088 16.1 0.2 1.1 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 RRN7 PF11781.3 AIC16287.1 - 0.01 15.2 0.4 1.4 8.5 0.0 2.1 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C3HC4_3 PF13920.1 AIC16287.1 - 0.026 14.2 1.4 0.05 13.2 0.9 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-TFIIB PF13453.1 AIC16287.1 - 0.029 13.5 0.4 0.17 11.0 0.0 2.0 2 0 0 2 2 2 0 Transcription factor zinc-finger Rtf2 PF04641.7 AIC16287.1 - 0.038 13.1 0.2 0.039 13.1 0.2 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger Rubredoxin PF00301.15 AIC16287.1 - 0.049 13.5 0.2 1.4 8.8 0.0 2.1 2 0 0 2 2 2 0 Rubredoxin GFA PF04828.9 AIC16287.1 - 0.05 13.5 0.8 4.9 7.1 0.0 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme zf-Sec23_Sec24 PF04810.10 AIC16287.1 - 0.059 12.9 3.0 0.46 10.0 0.3 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Zn-ribbon_8 PF09723.5 AIC16287.1 - 0.066 13.1 1.6 0.55 10.2 1.1 2.0 1 1 1 2 2 2 0 Zinc ribbon domain zf-ISL3 PF14690.1 AIC16287.1 - 0.074 13.0 0.2 5.6 7.0 0.0 2.1 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Zn_Tnp_IS1595 PF12760.2 AIC16287.1 - 0.079 12.7 2.4 3.5 7.5 0.1 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-CHY PF05495.7 AIC16287.1 - 0.08 13.1 0.3 0.096 12.8 0.2 1.1 1 0 0 1 1 1 0 CHY zinc finger ADK_lid PF05191.9 AIC16287.1 - 0.097 12.3 0.7 5.5 6.7 0.1 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid DUF35_N PF12172.3 AIC16287.1 - 0.11 12.4 0.6 10 6.1 0.1 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Nudix_N_2 PF14803.1 AIC16287.1 - 0.11 12.2 4.8 1.7 8.4 0.6 2.2 2 0 0 2 2 2 0 Nudix N-terminal A2L_zn_ribbon PF08792.5 AIC16287.1 - 0.12 11.9 0.9 2.2 7.8 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zinc_ribbon_5 PF13719.1 AIC16287.1 - 0.12 12.0 0.9 7.3 6.2 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC16287.1 - 0.18 11.5 0.8 12 5.6 0.0 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF164 PF02591.10 AIC16287.1 - 0.18 11.6 1.3 1.9 8.4 1.4 1.8 1 1 1 2 2 2 0 Putative zinc ribbon domain Lar_restr_allev PF14354.1 AIC16287.1 - 0.18 12.1 3.1 6 7.2 0.1 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar OrfB_Zn_ribbon PF07282.6 AIC16287.1 - 0.18 11.4 0.7 0.94 9.1 0.5 1.8 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Ribosomal_S27 PF01599.14 AIC16287.1 - 0.2 11.4 1.0 3.9 7.3 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein S27a Zn_ribbon_recom PF13408.1 AIC16287.1 - 0.22 11.8 3.3 5.2 7.4 0.8 2.1 1 1 1 2 2 2 0 Recombinase zinc beta ribbon domain DNA_ligase_ZBD PF03119.11 AIC16287.1 - 0.24 11.1 0.6 0.24 11.1 0.4 2.1 2 1 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain ALMT PF11744.3 AIC16288.1 - 0.035 12.7 0.5 0.038 12.6 0.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Seryl_tRNA_N PF02403.17 AIC16288.1 - 0.067 13.2 7.8 0.1 12.6 5.4 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Muted PF14942.1 AIC16288.1 - 0.099 12.5 4.3 0.13 12.1 3.0 1.2 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF4337 PF14235.1 AIC16288.1 - 0.1 12.4 0.8 0.13 12.1 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) YlqD PF11068.3 AIC16288.1 - 0.11 12.5 2.7 0.23 11.4 1.9 1.6 1 1 0 1 1 1 0 YlqD protein Vma12 PF11712.3 AIC16288.1 - 0.19 11.4 2.3 0.38 10.4 1.6 1.5 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase NPV_P10 PF05531.7 AIC16288.1 - 0.23 11.7 3.1 2.6 8.3 1.7 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Occludin_ELL PF07303.8 AIC16288.1 - 0.32 11.7 0.2 0.32 11.7 0.1 2.8 1 1 0 2 2 2 0 Occludin homology domain APG6 PF04111.7 AIC16288.1 - 0.33 9.9 6.1 0.42 9.5 4.2 1.2 1 0 0 1 1 1 0 Autophagy protein Apg6 AAA_23 PF13476.1 AIC16288.1 - 2 8.6 8.3 2.9 8.1 5.7 1.3 1 0 0 1 1 1 0 AAA domain Pox_A_type_inc PF04508.7 AIC16288.1 - 4 7.4 0.0 4 7.4 0.0 3.9 3 2 0 3 3 3 0 Viral A-type inclusion protein repeat DUF342 PF03961.8 AIC16288.1 - 4.2 5.6 6.1 5.7 5.2 4.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF342) Sdh5 PF03937.11 AIC16288.1 - 5.5 6.7 7.5 4.1 7.1 0.2 2.7 3 0 0 3 3 3 0 Flavinator of succinate dehydrogenase DUF35 PF01796.12 AIC16289.1 - 1.3e-06 28.4 0.1 1.9e-06 27.9 0.1 1.2 1 0 0 1 1 1 1 DUF35 OB-fold domain zinc_ribbon_2 PF13240.1 AIC16289.1 - 0.00055 19.3 0.5 0.001 18.4 0.3 1.4 1 0 0 1 1 1 1 zinc-ribbon domain FYVE PF01363.16 AIC16289.1 - 0.0023 17.7 0.1 0.0026 17.6 0.0 1.2 1 0 0 1 1 1 1 FYVE zinc finger DZR PF12773.2 AIC16289.1 - 0.0092 15.7 0.4 0.014 15.2 0.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon Prok-RING_1 PF14446.1 AIC16289.1 - 0.042 13.5 1.1 0.062 13.0 0.8 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 MTHFR_C PF12225.3 AIC16289.1 - 0.046 13.2 0.6 0.065 12.7 0.4 1.2 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal zinc_ribbon_4 PF13717.1 AIC16289.1 - 0.056 13.1 0.9 1.8 8.3 0.1 2.9 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC16289.1 - 0.064 12.8 1.3 1.8 8.2 0.1 3.0 3 0 0 3 3 3 0 zinc-ribbon domain DUF35_N PF12172.3 AIC16289.1 - 0.088 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) A2L_zn_ribbon PF08792.5 AIC16289.1 - 0.12 11.8 2.9 0.34 10.4 2.0 1.7 1 1 0 1 1 1 0 A2L zinc ribbon domain DUF2082 PF09855.4 AIC16289.1 - 0.14 12.0 1.9 7.8 6.4 0.1 2.4 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-ribbon_3 PF13248.1 AIC16289.1 - 0.21 10.8 2.5 0.72 9.1 1.8 1.9 1 1 1 2 2 2 0 zinc-ribbon domain Auto_anti-p27 PF06677.7 AIC16289.1 - 1 9.1 4.1 5.6 6.8 3.2 1.8 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Thiolase_C PF02803.13 AIC16290.1 - 1.8e-13 49.9 0.7 1.3e-09 37.5 0.0 3.4 2 2 1 3 3 3 2 Thiolase, C-terminal domain Thiolase_N PF00108.18 AIC16290.1 - 9.8e-09 34.5 0.8 5.5e-08 32.1 0.4 2.2 3 0 0 3 3 3 1 Thiolase, N-terminal domain ketoacyl-synt PF00109.21 AIC16290.1 - 0.00014 21.4 2.7 0.025 14.0 0.4 2.6 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.17 AIC16290.1 - 0.0028 17.4 0.4 0.17 11.7 0.0 3.1 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain ACP_syn_III PF08545.5 AIC16290.1 - 0.04 13.5 0.2 7.6 6.2 0.1 2.8 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III Topoisom_bac PF01131.15 AIC16291.1 - 9.5e-104 347.4 0.0 1.1e-103 347.1 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.17 AIC16291.1 - 8.8e-12 44.8 0.0 1.9e-11 43.8 0.0 1.6 1 0 0 1 1 1 1 Toprim domain zf-C4_Topoisom PF01396.14 AIC16291.1 - 0.00033 20.0 1.5 0.00067 19.1 1.1 1.6 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger DUF2367 PF10164.4 AIC16291.1 - 0.026 14.3 0.1 0.068 13.0 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) zf-FPG_IleRS PF06827.9 AIC16292.1 - 0.22 11.2 0.2 0.22 11.2 0.1 2.0 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS bPH_3 PF14470.1 AIC16293.1 - 7.7e-14 51.7 0.0 7.2e-13 48.6 0.0 2.1 1 1 0 1 1 1 1 Bacterial PH domain SHOCT PF09851.4 AIC16293.1 - 1.5e-10 40.1 1.9 9.5e-10 37.6 1.2 2.2 2 0 0 2 2 2 1 Short C-terminal domain bPH_2 PF03703.9 AIC16293.1 - 0.14 12.2 0.3 0.42 10.6 0.2 1.9 1 1 0 1 1 1 0 Bacterial PH domain CN_hydrolase PF00795.17 AIC16294.1 - 2.2e-31 108.6 0.0 3.1e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Tautomerase PF01361.16 AIC16295.1 - 2.7e-14 52.4 0.0 2.9e-14 52.3 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.1 AIC16295.1 - 7.8e-11 41.8 0.0 8.5e-11 41.7 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_3 PF14832.1 AIC16295.1 - 0.0025 17.8 0.0 0.0026 17.7 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme DUF1904 PF08921.6 AIC16295.1 - 0.04 13.9 0.0 0.042 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) Ketoacyl-synt_2 PF13723.1 AIC16295.1 - 0.06 12.6 0.0 0.069 12.3 0.0 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain HTH_19 PF12844.2 AIC16296.1 - 5.3e-10 39.1 0.0 8.8e-10 38.4 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.17 AIC16296.1 - 2.5e-08 33.6 0.0 3.9e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.1 AIC16296.1 - 3.6e-08 33.5 0.0 6.2e-08 32.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.1 AIC16296.1 - 0.029 14.1 0.0 0.046 13.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain MerR_1 PF13411.1 AIC16296.1 - 0.07 12.9 0.0 5.1 6.9 0.0 2.4 1 1 1 2 2 2 0 MerR HTH family regulatory protein HTH_Tnp_1 PF01527.15 AIC16296.1 - 0.19 11.7 0.8 2.6 8.0 0.6 2.5 1 1 0 1 1 1 0 Transposase UDG PF03167.14 AIC16297.1 - 8.1e-31 106.5 0.0 1.2e-30 105.9 0.0 1.3 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily TFIIE_alpha PF02002.12 AIC16298.1 - 4.6e-21 74.3 1.0 4.6e-21 74.3 0.7 1.9 2 0 0 2 2 2 1 TFIIE alpha subunit Siah-Interact_N PF09032.6 AIC16298.1 - 0.015 15.3 4.8 0.015 15.3 3.4 2.2 2 1 1 3 3 3 0 Siah interacting protein, N terminal Y1_Tnp PF01797.11 AIC16298.1 - 0.046 13.5 0.2 0.098 12.5 0.1 1.5 1 0 0 1 1 1 0 Transposase IS200 like HTH_9 PF08221.6 AIC16298.1 - 0.084 12.7 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain D5_N PF08706.6 AIC16298.1 - 8.4 6.4 11.4 54 3.8 7.9 2.0 1 1 0 1 1 1 0 D5 N terminal like VMA21 PF09446.5 AIC16299.1 - 0.073 13.0 0.4 0.14 12.1 0.3 1.5 1 0 0 1 1 1 0 VMA21-like domain DUF3693 PF12472.3 AIC16299.1 - 3.2 7.4 5.0 1.3 8.7 1.7 1.6 2 0 0 2 2 2 0 Phage related protein Guanylate_cyc PF00211.15 AIC16301.1 - 1.9e-16 59.9 0.0 4.3e-16 58.8 0.0 1.5 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HTH_29 PF13551.1 AIC16301.1 - 0.006 16.7 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix HTH_23 PF13384.1 AIC16301.1 - 0.011 15.3 0.0 0.053 13.2 0.0 2.0 2 0 0 2 2 2 0 Homeodomain-like domain RNA_polI_A14 PF08203.6 AIC16301.1 - 0.1 12.8 1.4 7.1 6.9 0.1 2.5 1 1 1 2 2 2 0 Yeast RNA polymerase I subunit RPA14 Response_reg PF00072.19 AIC16303.1 - 3.4e-13 49.5 0.0 3.7e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Response regulator receiver domain COX15-CtaA PF02628.10 AIC16304.1 - 4.3e-17 61.9 8.1 6.8e-17 61.2 5.6 1.4 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein E1-E2_ATPase PF00122.15 AIC16304.1 - 0.094 11.7 2.7 0.25 10.3 1.9 1.8 1 1 0 1 1 1 0 E1-E2 ATPase DUF898 PF05987.8 AIC16304.1 - 0.11 11.3 8.9 0.15 10.9 1.8 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF898) DZR PF12773.2 AIC16305.1 - 0.00025 20.8 0.7 0.00028 20.6 0.5 1.1 1 0 0 1 1 1 1 Double zinc ribbon DNA_RNApol_7kD PF03604.8 AIC16305.1 - 0.0021 17.4 1.2 0.16 11.4 0.1 2.1 2 0 0 2 2 2 1 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_2 PF13240.1 AIC16305.1 - 0.0078 15.6 2.5 0.011 15.2 1.7 1.2 1 0 0 1 1 1 1 zinc-ribbon domain HypA PF01155.14 AIC16305.1 - 0.01 15.4 0.5 0.011 15.4 0.3 1.0 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zinc-ribbons_6 PF07191.7 AIC16305.1 - 0.018 14.8 0.6 0.02 14.6 0.4 1.1 1 0 0 1 1 1 0 zinc-ribbons C1_1 PF00130.17 AIC16305.1 - 0.039 13.6 2.0 0.054 13.2 1.4 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Cytochrom_CIII PF02085.11 AIC16305.1 - 0.039 14.0 0.4 0.039 14.0 0.3 1.0 1 0 0 1 1 1 0 Class III cytochrome C family zf-ribbon_3 PF13248.1 AIC16305.1 - 0.076 12.2 2.3 0.45 9.7 1.8 1.9 1 1 1 2 2 2 0 zinc-ribbon domain PHD PF00628.24 AIC16305.1 - 0.081 12.6 0.9 0.11 12.1 0.6 1.2 1 0 0 1 1 1 0 PHD-finger zf-CHY PF05495.7 AIC16305.1 - 0.094 12.8 1.1 2.7 8.2 1.1 2.0 1 1 1 2 2 2 0 CHY zinc finger DUF1272 PF06906.6 AIC16305.1 - 0.19 11.6 1.5 0.46 10.3 0.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) zf-AD PF07776.10 AIC16305.1 - 0.29 11.1 1.4 2.1 8.4 0.0 1.9 1 1 1 2 2 2 0 Zinc-finger associated domain (zf-AD) Cytochrome_C7 PF14522.1 AIC16305.1 - 0.31 10.7 2.0 0.73 9.5 1.4 1.7 1 1 0 1 1 1 0 Cytochrome c7 Mss4 PF04421.8 AIC16305.1 - 0.37 10.6 1.6 0.44 10.3 1.1 1.5 1 1 0 1 1 1 0 Mss4 protein Paired_CXXCH_1 PF09699.5 AIC16305.1 - 0.45 10.0 4.3 0.95 9.0 3.0 1.6 1 1 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) XPA_N PF01286.13 AIC16305.1 - 0.46 10.1 4.9 1.4 8.6 0.5 2.2 1 1 1 2 2 2 0 XPA protein N-terminal Mu-like_Com PF10122.4 AIC16305.1 - 1.5 7.9 5.5 2.3 7.3 0.2 2.1 1 1 1 2 2 2 0 Mu-like prophage protein Com zf-C2H2_6 PF13912.1 AIC16305.1 - 3.3 7.7 6.3 13 5.8 0.6 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger HTH_24 PF13412.1 AIC16306.1 - 8.9e-05 21.7 0.4 0.00024 20.4 0.1 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.7 AIC16306.1 - 0.00041 19.9 0.1 0.001 18.6 0.1 1.6 1 0 0 1 1 1 1 HTH domain HTH_AsnC-type PF13404.1 AIC16306.1 - 0.0011 18.4 0.1 0.002 17.5 0.1 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain Mga PF05043.8 AIC16306.1 - 0.0051 17.0 0.5 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 Mga helix-turn-helix domain HTH_psq PF05225.11 AIC16306.1 - 0.039 13.4 0.0 0.098 12.2 0.0 1.6 2 0 0 2 2 2 0 helix-turn-helix, Psq domain HTH_23 PF13384.1 AIC16306.1 - 0.061 13.0 0.0 0.15 11.7 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain DNA_pol_E_B PF04042.11 AIC16308.1 - 2.5e-20 72.6 0.0 6.7e-20 71.2 0.0 1.7 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B Metallophos_2 PF12850.2 AIC16308.1 - 1.7e-10 40.9 0.0 3.1e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 AIC16308.1 - 3.6e-06 26.4 0.2 1.1e-05 24.8 0.1 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase tRNA_anti-codon PF01336.20 AIC16308.1 - 2.5e-05 24.0 0.0 4.7e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2415 PF10313.4 AIC16308.1 - 0.1 12.2 0.0 0.21 11.3 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Cdc6_C PF09079.6 AIC16309.1 - 1.4e-21 75.9 0.3 4.9e-21 74.2 0.1 2.1 2 0 0 2 2 1 1 CDC6, C terminal AAA_16 PF13191.1 AIC16309.1 - 4.7e-13 49.5 1.6 5.6e-12 46.0 0.0 3.0 2 2 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 AIC16309.1 - 1.7e-12 47.7 2.6 2.5e-12 47.1 0.1 2.5 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.1 AIC16309.1 - 1.1e-09 38.5 0.1 6.6e-09 36.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.8 AIC16309.1 - 9.1e-06 24.7 0.3 4.7e-05 22.4 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) Arch_ATPase PF01637.13 AIC16309.1 - 4.6e-05 23.2 1.3 8.8e-05 22.3 0.1 2.0 2 0 0 2 2 2 1 Archaeal ATPase NACHT PF05729.7 AIC16309.1 - 0.00043 19.9 1.3 0.003 17.2 0.3 2.5 2 1 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.9 AIC16309.1 - 0.0006 18.9 0.7 0.14 11.1 0.0 2.5 1 1 1 2 2 2 1 KAP family P-loop domain NB-ARC PF00931.17 AIC16309.1 - 0.0012 17.7 0.1 0.0021 16.9 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.1 AIC16309.1 - 0.0013 18.4 0.3 0.0043 16.7 0.2 1.9 1 0 0 1 1 1 1 Part of AAA domain AAA_10 PF12846.2 AIC16309.1 - 0.0072 15.7 3.3 0.4 10.0 0.1 3.1 2 1 1 3 3 3 1 AAA-like domain TrwB_AAD_bind PF10412.4 AIC16309.1 - 0.011 14.4 0.1 3.1 6.3 0.0 2.4 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.1 AIC16309.1 - 0.015 14.9 0.8 0.074 12.6 0.0 2.3 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.1 AIC16309.1 - 0.017 15.4 0.7 0.045 14.0 0.0 2.1 3 0 0 3 3 2 0 AAA domain ResIII PF04851.10 AIC16309.1 - 0.017 14.9 0.2 0.042 13.6 0.0 1.8 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit KaiC PF06745.8 AIC16309.1 - 0.018 14.1 0.3 0.018 14.1 0.2 1.9 2 2 0 2 2 2 0 KaiC AAA_11 PF13086.1 AIC16309.1 - 0.019 14.5 0.1 0.041 13.4 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 AIC16309.1 - 0.02 14.6 0.2 0.1 12.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 AIC16309.1 - 0.03 14.1 0.6 0.14 12.0 0.0 2.3 2 1 1 3 3 3 0 AAA domain Zeta_toxin PF06414.7 AIC16309.1 - 0.039 13.0 1.3 0.062 12.3 0.0 2.0 2 1 0 2 2 2 0 Zeta toxin Miro PF08477.8 AIC16309.1 - 0.05 14.1 0.5 0.15 12.5 0.0 2.0 2 0 0 2 2 2 0 Miro-like protein DUF2075 PF09848.4 AIC16309.1 - 0.065 12.2 0.6 0.11 11.3 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) FtsK_SpoIIIE PF01580.13 AIC16309.1 - 0.066 12.6 0.6 0.15 11.4 0.0 1.9 2 1 0 2 2 2 0 FtsK/SpoIIIE family ABC_tran PF00005.22 AIC16309.1 - 0.074 13.3 2.6 3.3 8.0 0.1 3.1 2 2 1 3 3 3 0 ABC transporter AAA_25 PF13481.1 AIC16309.1 - 0.11 11.9 3.9 0.48 9.8 0.6 2.8 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 AIC16309.1 - 0.12 12.6 0.0 0.31 11.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.10 AIC16309.1 - 0.26 10.9 6.1 0.11 12.1 1.8 2.2 2 1 0 2 2 1 0 NTPase Penicillinase_R PF03965.11 AIC16310.1 - 0.046 13.8 0.0 0.067 13.2 0.0 1.3 1 0 0 1 1 1 0 Penicillinase repressor HTH_27 PF13463.1 AIC16311.1 - 2.2e-05 24.6 0.0 6e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.14 AIC16311.1 - 0.00016 21.3 0.0 0.00028 20.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.2 AIC16311.1 - 0.014 15.2 0.1 0.032 14.0 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_5 PF01022.15 AIC16311.1 - 0.042 13.5 0.0 0.086 12.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.1 AIC16311.1 - 0.045 13.1 0.0 0.091 12.1 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC16311.1 - 0.047 13.3 0.0 0.11 12.1 0.0 1.6 1 0 0 1 1 1 0 MarR family HxlR PF01638.12 AIC16311.1 - 0.049 13.2 0.1 0.11 12.1 0.1 1.5 1 0 0 1 1 1 0 HxlR-like helix-turn-helix HTH_IclR PF09339.5 AIC16311.1 - 0.063 12.8 0.2 0.11 12.0 0.2 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain CTP_transf_3 PF02348.14 AIC16311.1 - 0.11 12.0 1.4 0.13 11.8 0.9 1.2 1 0 0 1 1 1 0 Cytidylyltransferase HTH_34 PF13601.1 AIC16311.1 - 0.12 12.4 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain PcrB PF01884.12 AIC16313.1 - 3e-68 229.5 0.4 3.8e-68 229.2 0.3 1.0 1 0 0 1 1 1 1 PcrB family His_biosynth PF00977.16 AIC16313.1 - 3.6e-08 32.9 0.1 4.7e-07 29.3 0.0 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein Trp_syntA PF00290.15 AIC16313.1 - 2.4e-05 23.0 0.4 5.9e-05 21.7 0.1 1.7 2 0 0 2 2 2 1 Tryptophan synthase alpha chain IMPDH PF00478.20 AIC16313.1 - 3.2e-05 23.0 0.6 6.8e-05 21.9 0.4 1.7 1 1 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain NanE PF04131.9 AIC16313.1 - 0.00047 19.1 1.1 0.0071 15.3 0.1 2.3 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase Ribul_P_3_epim PF00834.14 AIC16313.1 - 0.0014 17.7 0.5 0.0026 16.9 0.2 1.5 2 0 0 2 2 2 1 Ribulose-phosphate 3 epimerase family IGPS PF00218.16 AIC16313.1 - 0.0023 17.0 0.2 0.058 12.4 0.0 2.2 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase ThiG PF05690.9 AIC16313.1 - 0.0024 16.9 2.2 0.064 12.3 0.3 2.1 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG Glyco_tran_WecB PF03808.8 AIC16313.1 - 0.0045 16.4 0.3 0.054 12.9 0.1 2.3 2 1 0 2 2 2 1 Glycosyl transferase WecB/TagA/CpsF family NMO PF03060.10 AIC16313.1 - 0.0083 15.3 1.0 2.5 7.1 0.2 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase DHO_dh PF01180.16 AIC16313.1 - 0.015 14.3 0.5 0.015 14.3 0.4 1.6 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase FMN_dh PF01070.13 AIC16313.1 - 0.022 13.6 0.0 0.077 11.8 0.0 1.8 1 1 0 1 1 1 0 FMN-dependent dehydrogenase TMP-TENI PF02581.12 AIC16313.1 - 0.022 13.9 0.1 0.05 12.7 0.0 1.6 2 0 0 2 2 2 0 Thiamine monophosphate synthase/TENI BtpA PF03437.10 AIC16313.1 - 0.035 13.3 0.9 0.44 9.7 0.1 2.1 2 0 0 2 2 2 0 BtpA family OMPdecase PF00215.19 AIC16313.1 - 0.074 12.4 0.1 0.14 11.5 0.1 1.5 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family B12-binding PF02310.14 AIC16313.1 - 0.094 12.5 1.5 1.5 8.6 0.1 3.1 3 1 1 4 4 4 0 B12 binding domain Pyr_redox PF00070.22 AIC16313.1 - 0.17 12.3 1.5 0.61 10.5 1.1 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase PolC_DP2 PF03833.8 AIC16314.1 - 2.7e-269 895.6 2.5 2.3e-268 892.5 0.1 2.7 2 1 0 2 2 2 1 DNA polymerase II large subunit DP2 zinc-ribbons_6 PF07191.7 AIC16314.1 - 0.19 11.5 13.7 0.76 9.6 0.1 3.2 2 1 1 3 3 3 0 zinc-ribbons DUF1272 PF06906.6 AIC16314.1 - 3.2 7.6 13.1 0.73 9.7 2.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1272) Na_trans_assoc PF06512.8 AIC16315.1 - 0.56 10.1 7.5 0.82 9.5 5.2 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated Daxx PF03344.10 AIC16315.1 - 1.3 7.3 12.7 1.5 7.1 8.8 1.0 1 0 0 1 1 1 0 Daxx Family BUD22 PF09073.5 AIC16315.1 - 2.6 7.0 18.9 3.3 6.6 13.1 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.7 AIC16315.1 - 8.1 5.6 13.3 10 5.2 9.2 1.2 1 0 0 1 1 1 0 SDA1 ThiF PF00899.16 AIC16316.1 - 2.5e-48 163.3 0.4 3.9e-48 162.7 0.3 1.3 1 0 0 1 1 1 1 ThiF family MoeZ_MoeB PF05237.8 AIC16316.1 - 1.4e-22 79.0 0.2 3.2e-22 77.9 0.2 1.7 1 0 0 1 1 1 1 MoeZ/MoeB domain ThiS PF02597.15 AIC16316.1 - 1e-09 38.6 0.0 6e-09 36.2 0.0 2.3 2 0 0 2 2 2 1 ThiS family Shikimate_DH PF01488.15 AIC16316.1 - 2.8e-06 27.4 0.1 5.6e-06 26.4 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Saccharop_dh PF03435.13 AIC16316.1 - 7.7e-05 21.8 0.2 0.00013 21.0 0.1 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NAD_binding_7 PF13241.1 AIC16316.1 - 0.0052 17.0 0.2 0.014 15.6 0.1 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding TBP PF00352.16 AIC16316.1 - 0.015 14.6 0.0 0.041 13.2 0.0 1.7 2 0 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) 2-Hacid_dh_C PF02826.14 AIC16316.1 - 0.026 13.6 0.1 0.046 12.8 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 AIC16316.1 - 0.03 13.6 0.2 0.059 12.7 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Polysacc_synt_2 PF02719.10 AIC16316.1 - 0.031 13.1 0.0 0.058 12.2 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Fumerase_C PF05683.7 AIC16316.1 - 0.043 12.9 0.0 0.091 11.8 0.0 1.5 1 0 0 1 1 1 0 Fumarase C-terminus PALP PF00291.20 AIC16317.1 - 1.1e-64 218.6 0.7 1.2e-64 218.4 0.5 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NinF PF05810.7 AIC16317.1 - 0.0072 16.1 0.2 0.018 14.8 0.1 1.7 1 0 0 1 1 1 1 NinF protein PK_C PF02887.11 AIC16317.1 - 0.015 14.8 0.5 0.093 12.2 0.1 2.1 2 0 0 2 2 2 0 Pyruvate kinase, alpha/beta domain Fungal_lectin PF07938.7 AIC16317.1 - 0.076 12.2 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 Fungal fucose-specific lectin zinc_ribbon_2 PF13240.1 AIC16317.1 - 0.71 9.4 5.0 1.3 8.6 3.5 1.4 1 0 0 1 1 1 0 zinc-ribbon domain C1_3 PF07649.7 AIC16317.1 - 1 9.4 3.5 1.9 8.6 2.4 1.4 1 0 0 1 1 1 0 C1-like domain PRA-CH PF01502.13 AIC16318.1 - 3.1e-34 116.4 0.1 3.8e-34 116.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase DUF4207 PF13904.1 AIC16319.1 - 0.2 11.0 7.8 0.19 11.0 5.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) Ripply PF14998.1 AIC16319.1 - 0.38 10.8 2.6 0.43 10.7 1.8 1.1 1 0 0 1 1 1 0 Transcription Regulator Atrophin-1 PF03154.10 AIC16319.1 - 1.1 7.3 3.7 1 7.4 2.6 1.0 1 0 0 1 1 1 0 Atrophin-1 family DUF1743 PF08489.6 AIC16321.1 - 3e-30 104.4 0.0 4.5e-30 103.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) OrfB_Zn_ribbon PF07282.6 AIC16321.1 - 0.036 13.7 1.0 0.087 12.4 0.7 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain C1_1 PF00130.17 AIC16321.1 - 0.089 12.5 1.7 0.26 11.0 1.2 1.7 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) YCII PF03795.9 AIC16321.1 - 0.11 12.6 0.0 0.8 9.9 0.0 2.2 2 0 0 2 2 2 0 YCII-related domain Abhydrolase_9 PF10081.4 AIC16321.1 - 0.16 10.6 0.0 0.27 9.9 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Fer4 PF00037.22 AIC16323.1 - 5.3e-11 41.6 10.4 4.1e-07 29.3 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 AIC16323.1 - 1e-09 38.6 4.3 1.3e-09 38.2 3.0 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.1 AIC16323.1 - 3.4e-08 33.1 3.0 6.4e-08 32.2 2.1 1.4 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.2 AIC16323.1 - 6.2e-08 32.1 9.6 3.6e-05 23.4 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.2 AIC16323.1 - 2.8e-07 30.0 8.4 0.0031 17.3 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.1 AIC16323.1 - 4e-06 26.5 5.6 7.9e-06 25.6 3.9 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_9 PF13187.1 AIC16323.1 - 8.5e-06 25.9 6.4 2.9e-05 24.2 4.6 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.1 AIC16323.1 - 4e-05 23.8 5.3 0.07 13.5 0.7 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_4 PF12800.2 AIC16323.1 - 8.4e-05 22.6 8.8 0.031 14.6 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_16 PF13484.1 AIC16323.1 - 0.00011 22.8 1.6 0.24 12.1 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_8 PF13183.1 AIC16323.1 - 0.00013 21.9 4.1 0.00038 20.4 2.9 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_15 PF13459.1 AIC16323.1 - 0.00015 22.2 9.9 0.0058 17.1 0.8 2.7 1 1 1 2 2 2 2 4Fe-4S single cluster domain Fer4_3 PF12798.2 AIC16323.1 - 0.00053 20.3 14.0 0.073 13.6 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_17 PF13534.1 AIC16323.1 - 0.0016 18.7 6.3 0.034 14.4 4.4 2.1 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_18 PF13746.1 AIC16323.1 - 0.0025 18.2 6.5 0.18 12.2 1.6 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain AFP PF02420.10 AIC16323.1 - 0.13 12.4 0.4 0.13 12.4 0.3 2.4 3 0 0 3 3 2 0 Insect antifreeze protein repeat bPH_3 PF14470.1 AIC16325.1 - 0.0002 21.5 0.0 0.011 16.0 0.0 2.1 2 0 0 2 2 2 2 Bacterial PH domain AsnC_trans_reg PF01037.16 AIC16326.1 - 1.4e-12 47.0 0.2 1.4e-12 47.0 0.1 1.1 1 0 0 1 1 1 1 AsnC family GYD PF08734.6 AIC16326.1 - 0.00062 19.4 0.0 0.00067 19.3 0.0 1.2 1 0 0 1 1 1 1 GYD domain UTP15_C PF09384.5 AIC16326.1 - 0.088 12.4 0.0 0.096 12.3 0.0 1.2 1 0 0 1 1 1 0 UTP15 C terminal TP_methylase PF00590.15 AIC16327.1 - 1.1e-31 110.1 0.0 1.3e-31 109.9 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases PAC2 PF09754.4 AIC16328.1 - 3.2e-33 115.4 0.0 3.8e-33 115.2 0.0 1.0 1 0 0 1 1 1 1 PAC2 family Glycolipid_bind PF06475.6 AIC16329.1 - 4.4e-61 205.1 0.0 5e-61 204.9 0.0 1.0 1 0 0 1 1 1 1 Putative glycolipid-binding MspA PF09203.6 AIC16329.1 - 0.015 14.7 0.0 0.021 14.2 0.0 1.2 1 0 0 1 1 1 0 MspA ABM PF03992.11 AIC16331.1 - 2.3e-09 37.1 0.0 2.6e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase DUF95 PF01944.12 AIC16332.1 - 4e-09 36.3 5.8 5.2e-09 35.9 4.0 1.1 1 0 0 1 1 1 1 Integral membrane protein DUF95 Na_H_Exchanger PF00999.16 AIC16333.1 - 2.7e-64 217.0 54.1 3.3e-64 216.7 37.5 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Asp-Al_Ex PF06826.7 AIC16333.1 - 0.061 12.8 32.4 0.15 11.5 5.7 3.4 2 1 0 2 2 2 0 Predicted Permease Membrane Region MIP PF00230.15 AIC16334.1 - 3.5e-34 118.2 19.9 4.1e-34 118.0 13.8 1.0 1 0 0 1 1 1 1 Major intrinsic protein DUF2105 PF09878.4 AIC16334.1 - 0.0067 16.0 4.5 0.013 15.0 3.1 1.5 1 0 0 1 1 1 1 Predicted membrane protein (DUF2105) Papilloma_E5 PF03025.9 AIC16334.1 - 0.015 15.1 0.7 0.049 13.5 0.5 1.8 1 0 0 1 1 1 0 Papillomavirus E5 LMWPc PF01451.16 AIC16335.1 - 2e-26 92.9 0.0 3.9e-26 92.0 0.0 1.4 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Methyltransf_31 PF13847.1 AIC16336.1 - 3.6e-34 117.5 0.0 6.2e-34 116.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC16336.1 - 4.9e-21 75.0 0.5 1.2e-20 73.7 0.0 1.9 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC16336.1 - 3.4e-16 59.8 0.1 7.1e-16 58.7 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC16336.1 - 4.6e-15 55.3 0.2 9.1e-15 54.4 0.1 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.1 AIC16336.1 - 2.1e-12 47.0 0.0 3.1e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC16336.1 - 2.6e-11 43.5 0.0 6.4e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC16336.1 - 5.4e-11 42.7 1.9 8.6e-11 42.0 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.14 AIC16336.1 - 1.4e-10 41.1 0.1 2.8e-10 40.0 0.1 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.7 AIC16336.1 - 6e-10 39.4 0.6 1.3e-09 38.4 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.8 AIC16336.1 - 1.4e-06 27.6 0.2 2.3e-06 26.9 0.1 1.3 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 AIC16336.1 - 2.1e-06 27.2 0.1 4.2e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.15 AIC16336.1 - 4.9e-05 22.5 0.0 6.7e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_8 PF05148.10 AIC16336.1 - 5.4e-05 22.9 0.0 0.00011 21.9 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_32 PF13679.1 AIC16336.1 - 0.00034 20.2 0.0 0.00055 19.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.13 AIC16336.1 - 0.00056 19.1 0.1 0.00096 18.4 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase UPF0020 PF01170.13 AIC16336.1 - 0.00066 19.3 0.1 0.0012 18.4 0.0 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 NNMT_PNMT_TEMT PF01234.12 AIC16336.1 - 0.0011 17.9 0.0 0.6 9.0 0.0 2.1 2 0 0 2 2 2 2 NNMT/PNMT/TEMT family DOT1 PF08123.8 AIC16336.1 - 0.017 14.4 0.1 0.032 13.5 0.1 1.5 1 1 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_29 PF03141.11 AIC16336.1 - 0.019 13.2 0.0 0.026 12.8 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_24 PF13578.1 AIC16336.1 - 0.041 14.7 0.0 0.082 13.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_4 PF02390.12 AIC16336.1 - 0.11 11.4 0.0 0.77 8.7 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase HxlR PF01638.12 AIC16337.1 - 4.2e-22 77.5 0.1 5.8e-22 77.1 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.9 AIC16337.1 - 0.00081 19.1 0.1 0.0012 18.6 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.1 AIC16337.1 - 0.00091 19.2 0.0 0.0013 18.7 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain RVT_3 PF13456.1 AIC16338.1 - 0.0012 18.5 0.2 0.0024 17.6 0.1 1.6 1 1 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.19 AIC16338.1 - 0.011 16.1 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 0 RNase H CHAD PF05235.9 AIC16340.1 - 8.4e-22 77.8 12.1 2.4e-20 73.1 5.9 2.1 1 1 1 2 2 2 2 CHAD domain Thymidylate_kin PF02223.12 AIC16341.1 - 2.6e-20 72.6 0.0 3.7e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Thymidylate kinase AAA_33 PF13671.1 AIC16341.1 - 0.0012 18.7 0.0 0.0025 17.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC16341.1 - 0.0094 16.7 0.2 0.85 10.4 0.1 2.2 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.1 AIC16341.1 - 0.069 13.4 0.2 0.78 10.0 0.0 2.2 1 1 1 2 2 2 0 AAA domain dNK PF01712.14 AIC16341.1 - 0.1 12.4 0.1 0.17 11.8 0.1 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase Thymidylate_kin PF02223.12 AIC16342.1 - 8.8e-23 80.6 0.0 1.5e-22 79.8 0.0 1.4 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.1 AIC16342.1 - 0.00084 19.6 0.4 0.0084 16.4 0.1 2.5 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.1 AIC16342.1 - 0.015 15.1 0.0 0.032 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.1 AIC16342.1 - 0.017 15.9 0.1 0.051 14.3 0.1 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.1 AIC16342.1 - 0.02 15.0 0.0 0.04 14.0 0.0 1.5 2 0 0 2 2 2 0 AAA domain Gp37_Gp68 PF07505.6 AIC16342.1 - 0.058 12.5 0.1 0.41 9.7 0.0 2.0 2 0 0 2 2 2 0 Phage protein Gp37/Gp68 Ppx-GppA PF02541.11 AIC16343.1 - 1.4e-47 162.3 0.0 5.9e-47 160.2 0.0 1.8 1 1 0 1 1 1 1 Ppx/GppA phosphatase family PYST-C1 PF09690.5 AIC16343.1 - 0.29 10.8 9.3 0.64 9.6 6.5 1.6 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) His_Phos_1 PF00300.17 AIC16344.1 - 1.4e-14 54.5 0.0 1.3e-12 48.1 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) zf-C3HC4_3 PF13920.1 AIC16346.1 - 0.032 13.8 0.1 0.044 13.4 0.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.14 AIC16346.1 - 0.07 12.8 0.0 0.079 12.6 0.0 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-C3HC4_2 PF13923.1 AIC16346.1 - 0.097 12.7 0.3 0.13 12.2 0.2 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_3 PF14369.1 AIC16346.1 - 0.32 11.0 2.2 1.2 9.2 1.7 1.9 1 1 1 2 2 2 0 zinc-finger PBP_like_2 PF12849.2 AIC16347.1 - 2.1e-54 184.8 6.8 2.1e-54 184.8 4.7 1.4 2 0 0 2 2 2 1 PBP superfamily domain PBP_like PF12727.2 AIC16347.1 - 2.1e-09 36.5 0.0 7.2e-09 34.8 0.0 1.7 1 1 0 1 1 1 1 PBP superfamily domain PBP_like_2 PF12849.2 AIC16348.1 - 3.4e-53 180.9 8.2 3.4e-53 180.9 5.7 2.0 2 0 0 2 2 2 1 PBP superfamily domain SBP_bac_1 PF01547.20 AIC16348.1 - 2.8e-16 60.1 8.1 2.8e-16 60.1 5.6 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein PBP_like PF12727.2 AIC16348.1 - 7.3e-08 31.5 0.0 2e-07 30.1 0.0 1.7 1 1 0 1 1 1 1 PBP superfamily domain BPD_transp_1 PF00528.17 AIC16349.1 - 3.9e-17 62.3 21.0 3.9e-17 62.3 14.6 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.17 AIC16350.1 - 6.7e-18 64.8 18.1 6.7e-18 64.8 12.5 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3333 PF11812.3 AIC16350.1 - 0.022 14.7 2.7 0.025 14.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3333) COX14 PF14880.1 AIC16350.1 - 0.034 13.7 0.0 0.12 12.0 0.0 1.9 1 0 0 1 1 1 0 Cytochrome oxidase c assembly ABC_tran PF00005.22 AIC16351.1 - 1.4e-30 106.3 0.0 2e-30 105.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC16351.1 - 3.4e-14 53.4 0.1 1.1e-10 41.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 AIC16351.1 - 1.4e-09 37.5 0.2 3.2e-08 33.0 0.1 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.1 AIC16351.1 - 5.4e-06 26.5 0.1 0.00014 22.0 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AIC16351.1 - 1.9e-05 24.7 0.0 0.0014 18.6 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_15 PF13175.1 AIC16351.1 - 6.2e-05 22.2 0.3 0.27 10.2 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain DUF258 PF03193.11 AIC16351.1 - 7.4e-05 21.9 0.0 0.00015 20.9 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA PF00004.24 AIC16351.1 - 0.00032 20.8 0.3 0.0047 17.1 0.2 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.1 AIC16351.1 - 0.00081 18.8 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Arch_ATPase PF01637.13 AIC16351.1 - 0.0018 17.9 0.0 0.051 13.2 0.0 2.1 2 0 0 2 2 2 1 Archaeal ATPase AAA_28 PF13521.1 AIC16351.1 - 0.0023 17.9 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.10 AIC16351.1 - 0.0043 15.7 0.0 0.0065 15.2 0.0 1.2 1 0 0 1 1 1 1 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 AIC16351.1 - 0.007 17.1 0.0 0.015 16.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.1 AIC16351.1 - 0.0086 16.3 0.1 0.025 14.8 0.0 1.8 2 0 0 2 2 1 1 AAA domain AAA_23 PF13476.1 AIC16351.1 - 0.0088 16.3 0.0 0.044 14.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 AIC16351.1 - 0.011 15.4 0.2 0.038 13.6 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.1 AIC16351.1 - 0.012 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.2 AIC16351.1 - 0.015 14.7 0.1 0.084 12.2 0.0 1.9 1 1 0 2 2 2 0 AAA-like domain PduV-EutP PF10662.4 AIC16351.1 - 0.016 14.6 0.1 0.031 13.7 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.1 AIC16351.1 - 0.019 14.5 0.1 0.042 13.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 AIC16351.1 - 0.023 14.4 0.0 0.66 9.7 0.0 2.4 2 0 0 2 2 2 0 Part of AAA domain NB-ARC PF00931.17 AIC16351.1 - 0.023 13.5 0.0 0.04 12.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_5 PF07728.9 AIC16351.1 - 0.024 14.3 0.0 0.046 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_ATPase PF09818.4 AIC16351.1 - 0.029 12.9 0.1 0.39 9.2 0.0 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class Viral_helicase1 PF01443.13 AIC16351.1 - 0.037 13.5 0.0 0.066 12.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Adeno_IVa2 PF02456.10 AIC16351.1 - 0.037 12.6 0.1 0.083 11.5 0.0 1.5 2 0 0 2 2 2 0 Adenovirus IVa2 protein AAA_14 PF13173.1 AIC16351.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 AIC16351.1 - 0.066 13.3 0.0 0.16 12.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.20 AIC16351.1 - 0.071 12.5 0.3 0.23 10.9 0.2 1.8 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.7 AIC16351.1 - 0.072 12.7 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_30 PF13604.1 AIC16351.1 - 0.096 12.2 0.3 0.24 10.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain cobW PF02492.14 AIC16351.1 - 0.13 11.7 0.5 0.27 10.6 0.1 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.12 AIC16351.1 - 0.14 11.5 0.2 0.46 9.8 0.0 1.8 2 0 0 2 2 2 0 IstB-like ATP binding protein PhoU PF01895.14 AIC16352.1 - 7.5e-29 100.0 2.6 7.2e-18 64.8 0.2 2.1 2 0 0 2 2 2 2 PhoU domain Peptidase_M19 PF01244.16 AIC16352.1 - 0.01 14.8 0.1 0.025 13.5 0.0 1.6 2 0 0 2 2 2 0 Membrane dipeptidase (Peptidase family M19) Pil1 PF13805.1 AIC16352.1 - 0.034 13.3 0.5 0.063 12.4 0.1 1.6 2 0 0 2 2 2 0 Eisosome component PIL1 DUF2034 PF10356.4 AIC16352.1 - 0.072 12.2 0.0 0.099 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) PhoU PF01895.14 AIC16353.1 - 1.7e-23 82.8 6.7 6e-17 61.8 0.9 2.6 2 0 0 2 2 2 2 PhoU domain Antitoxin-MazE PF04014.13 AIC16353.1 - 1.5e-05 24.6 0.0 6.9e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 Antidote-toxin recognition MazE Neur_chan_memb PF02932.11 AIC16354.1 - 7.4e-06 26.0 5.1 1.1e-05 25.4 3.5 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region 60KD_IMP PF02096.15 AIC16354.1 - 0.39 10.3 3.8 0.63 9.6 2.6 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein N6_N4_Mtase PF01555.13 AIC16355.1 - 7.6e-23 81.2 0.1 2.8e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 DNA methylase Dev_Cell_Death PF10539.4 AIC16355.1 - 2.5e-17 62.6 0.0 4.1e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 Development and cell death domain Methyltransf_26 PF13659.1 AIC16355.1 - 4.9e-10 39.4 0.1 1.7e-09 37.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC16355.1 - 4.4e-06 27.0 0.0 0.00011 22.5 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 AIC16355.1 - 7.3e-06 25.6 0.1 0.062 12.8 0.0 2.4 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_8 PF05148.10 AIC16355.1 - 0.00023 20.8 0.1 0.00067 19.3 0.0 1.7 2 0 0 2 2 2 1 Hypothetical methyltransferase Cons_hypoth95 PF03602.10 AIC16355.1 - 0.088 12.1 0.0 4.8 6.5 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical protein 95 zf-B_box PF00643.19 AIC16356.1 - 0.0044 16.8 6.7 0.0044 16.8 4.6 2.0 2 0 0 2 2 2 1 B-box zinc finger C6_DPF PF10170.4 AIC16356.1 - 0.058 13.4 4.6 0.076 13.0 3.2 1.3 1 1 0 1 1 1 0 Cysteine-rich domain Siva PF05458.7 AIC16356.1 - 0.2 11.2 4.6 0.2 11.2 3.2 1.1 1 0 0 1 1 1 0 Cd27 binding protein (Siva) FYVE_2 PF02318.11 AIC16356.1 - 0.21 11.4 8.9 0.38 10.6 6.2 1.5 1 1 0 1 1 1 0 FYVE-type zinc finger zf-C3HC4_3 PF13920.1 AIC16356.1 - 0.23 11.1 11.7 0.44 10.2 8.1 1.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Metallothio PF00131.15 AIC16356.1 - 0.37 10.6 8.1 0.42 10.5 5.6 1.2 1 0 0 1 1 1 0 Metallothionein DZR PF12773.2 AIC16356.1 - 3.3 7.6 10.8 2.2 8.1 1.0 2.1 1 1 1 2 2 2 0 Double zinc ribbon zf-HC5HC2H PF13771.1 AIC16356.1 - 4.1 7.6 9.5 9.8 6.4 4.5 2.0 1 1 1 2 2 2 0 PHD-like zinc-binding domain C1_1 PF00130.17 AIC16356.1 - 7.9 6.3 9.7 1.7 8.4 2.9 2.1 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-CXXC PF02008.15 AIC16356.1 - 8.6 6.2 12.4 63 3.4 0.0 2.7 2 1 0 2 2 2 0 CXXC zinc finger domain DUF4428 PF14471.1 AIC16356.1 - 9.9 6.0 11.4 20 5.0 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) NUDIX PF00293.23 AIC16357.1 - 2.6e-15 56.2 0.0 3.5e-15 55.8 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain MarR_2 PF12802.2 AIC16358.1 - 0.00013 21.5 0.0 0.00025 20.6 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_45 PF14947.1 AIC16358.1 - 0.026 14.3 1.0 0.047 13.5 0.7 1.4 1 1 0 1 1 1 0 Winged helix-turn-helix Rio2_N PF09202.6 AIC16358.1 - 0.079 13.0 0.1 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 Rio2, N-terminal HTH_27 PF13463.1 AIC16358.1 - 0.095 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF4271 PF14093.1 AIC16358.1 - 0.1 12.2 0.1 0.17 11.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) NikR_C PF08753.6 AIC16360.1 - 2.9e-12 46.2 0.8 4.3e-12 45.7 0.6 1.3 1 0 0 1 1 1 1 NikR C terminal nickel binding domain RHH_1 PF01402.16 AIC16360.1 - 7.3e-06 25.6 0.1 1.4e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family DUF2191 PF09957.4 AIC16360.1 - 0.0037 17.0 0.0 0.0076 16.0 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2191) RPA PF10134.4 AIC16360.1 - 0.061 12.5 0.0 0.075 12.2 0.0 1.2 1 0 0 1 1 1 0 Replication initiator protein A NikR_C PF08753.6 AIC16361.1 - 1e-11 44.5 0.3 1.4e-11 44.0 0.2 1.2 1 0 0 1 1 1 1 NikR C terminal nickel binding domain RHH_1 PF01402.16 AIC16361.1 - 0.037 13.9 0.7 0.2 11.6 0.0 2.5 3 0 0 3 3 3 0 Ribbon-helix-helix protein, copG family TroA PF01297.12 AIC16362.1 - 2.2e-74 249.9 0.0 2.6e-74 249.7 0.0 1.0 1 0 0 1 1 1 1 Periplasmic solute binding protein family ABC_tran PF00005.22 AIC16363.1 - 2.5e-33 115.2 0.0 1.1e-32 113.1 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.1 AIC16363.1 - 2.7e-15 57.1 0.1 2.2e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 AIC16363.1 - 1.6e-09 38.3 0.1 2.4e-09 37.8 0.1 1.3 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 AIC16363.1 - 4.9e-06 25.8 0.4 0.0048 16.0 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 AIC16363.1 - 1e-05 24.9 0.5 0.017 14.3 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_10 PF12846.2 AIC16363.1 - 2.9e-05 23.6 1.3 0.002 17.6 0.1 2.1 1 1 0 2 2 2 1 AAA-like domain AAA_29 PF13555.1 AIC16363.1 - 8.2e-05 22.0 0.3 0.00017 21.0 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.24 AIC16363.1 - 0.00039 20.6 0.8 0.0024 18.0 0.6 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.17 AIC16363.1 - 0.0012 17.7 0.1 0.27 10.0 0.0 2.1 2 0 0 2 2 2 2 NB-ARC domain AAA_16 PF13191.1 AIC16363.1 - 0.0032 17.4 0.2 0.014 15.3 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain MobB PF03205.9 AIC16363.1 - 0.011 15.3 0.1 0.029 14.0 0.0 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B Arch_ATPase PF01637.13 AIC16363.1 - 0.016 14.9 0.0 0.03 14.0 0.0 1.5 2 0 0 2 2 2 0 Archaeal ATPase SbcCD_C PF13558.1 AIC16363.1 - 0.019 14.8 0.2 0.47 10.4 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit T2SE PF00437.15 AIC16363.1 - 0.022 13.6 0.4 0.11 11.3 0.1 2.0 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_33 PF13671.1 AIC16363.1 - 0.025 14.4 0.2 0.052 13.4 0.1 1.7 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.18 AIC16363.1 - 0.05 13.5 1.0 0.11 12.4 0.7 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_17 PF13207.1 AIC16363.1 - 0.059 14.2 0.6 0.17 12.7 0.1 2.0 2 1 0 2 2 2 0 AAA domain PhoH PF02562.11 AIC16363.1 - 0.079 12.1 1.1 1 8.5 0.0 2.7 1 1 1 3 3 3 0 PhoH-like protein Mg_chelatase PF01078.16 AIC16363.1 - 0.08 12.0 0.0 0.3 10.2 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NACHT PF05729.7 AIC16363.1 - 0.088 12.4 0.3 0.71 9.5 0.1 2.0 2 0 0 2 2 2 0 NACHT domain DEAD PF00270.24 AIC16363.1 - 0.095 12.1 0.1 1.1 8.7 0.1 2.1 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF258 PF03193.11 AIC16363.1 - 0.1 11.7 0.0 0.17 11.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF258 AAA_25 PF13481.1 AIC16363.1 - 0.15 11.4 0.4 0.71 9.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 AIC16363.1 - 0.2 11.8 1.9 1.2 9.2 0.2 2.2 2 0 0 2 2 2 0 AAA domain ABC-3 PF00950.12 AIC16364.1 - 3.7e-66 223.0 39.0 4.2e-66 222.8 27.0 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.13 AIC16364.1 - 9.6e-10 37.7 35.6 1.3e-09 37.2 21.3 2.1 1 1 1 2 2 2 2 FecCD transport family Imm-NTF2 PF15655.1 AIC16365.1 - 0.19 12.2 1.7 0.24 11.8 1.2 1.0 1 0 0 1 1 1 0 NTF2 fold immunity protein CelD_N PF02927.9 AIC16365.1 - 0.2 11.9 1.2 0.22 11.8 0.8 1.1 1 0 0 1 1 1 0 N-terminal ig-like domain of cellulase zf-C5HC2 PF02928.11 AIC16366.1 - 0.013 15.5 0.2 0.02 14.9 0.1 1.3 1 0 0 1 1 1 0 C5HC2 zinc finger Glyco_trans_1_3 PF13528.1 AIC16367.1 - 1.7e-13 50.4 0.0 2.4e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.11 AIC16367.1 - 1.2e-11 44.6 0.0 2e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_4 PF13692.1 AIC16367.1 - 0.021 14.9 0.0 0.062 13.4 0.0 1.8 2 0 0 2 2 2 0 Glycosyl transferases group 1 DUF2325 PF10087.4 AIC16367.1 - 0.14 12.0 0.1 3.3 7.6 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2325) Kelch_1 PF01344.20 AIC16370.1 - 1e-60 201.0 0.0 2.6e-12 46.0 0.0 6.3 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.1 AIC16370.1 - 6.5e-46 152.6 7.7 1.2e-11 44.2 0.0 7.2 2 2 5 7 7 7 6 Kelch motif Kelch_3 PF13415.1 AIC16370.1 - 3.2e-33 113.1 17.3 3e-09 36.7 0.0 7.3 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.10 AIC16370.1 - 7.1e-33 111.1 0.0 8.3e-05 22.1 0.0 6.5 7 0 0 7 7 7 6 Kelch motif Kelch_4 PF13418.1 AIC16370.1 - 4.7e-30 103.1 8.9 2.7e-09 36.6 0.0 6.8 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_5 PF13854.1 AIC16370.1 - 3.3e-27 93.9 10.3 0.00013 21.8 0.0 6.2 6 0 0 6 6 6 6 Kelch motif DUF1668 PF07893.8 AIC16370.1 - 9.1e-05 21.7 0.1 0.23 10.5 0.0 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF1668) BA14K PF07886.6 AIC16370.1 - 0.22 11.2 0.6 3.3 7.4 0.0 2.8 3 0 0 3 3 3 0 BA14K-like protein A2L_zn_ribbon PF08792.5 AIC16371.1 - 0.017 14.5 3.7 0.9 9.0 0.3 2.3 2 0 0 2 2 2 0 A2L zinc ribbon domain C1_1 PF00130.17 AIC16371.1 - 0.045 13.4 2.3 0.049 13.3 1.0 1.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Desulfoferrod_N PF06397.7 AIC16371.1 - 0.068 12.5 0.7 0.068 12.5 0.5 2.2 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-IS66 PF13005.2 AIC16371.1 - 0.071 13.0 4.9 0.16 11.9 0.2 2.2 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 Ribosomal_L37e PF01907.14 AIC16371.1 - 0.12 12.2 0.3 0.17 11.6 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L37e Zn-ribbon_8 PF09723.5 AIC16371.1 - 0.15 12.0 4.5 3.2 7.7 0.4 2.1 2 0 0 2 2 2 0 Zinc ribbon domain zf-NADH-PPase PF09297.6 AIC16371.1 - 0.15 11.5 2.6 4.8 6.7 0.4 2.3 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain DZR PF12773.2 AIC16371.1 - 0.2 11.4 1.6 0.36 10.6 0.7 1.7 1 1 0 1 1 1 0 Double zinc ribbon Rubredoxin PF00301.15 AIC16371.1 - 0.24 11.3 1.5 0.31 10.9 0.2 1.8 2 0 0 2 2 2 0 Rubredoxin Zn_Tnp_IS1595 PF12760.2 AIC16371.1 - 0.25 11.1 1.7 0.42 10.4 1.2 1.4 1 1 0 1 1 1 0 Transposase zinc-ribbon domain Zn_Tnp_IS91 PF14319.1 AIC16371.1 - 0.3 10.5 2.5 1.1 8.7 1.7 1.8 1 1 0 1 1 1 0 Transposase zinc-binding domain zf-ISL3 PF14690.1 AIC16371.1 - 1 9.4 3.9 5.1 7.1 0.1 2.1 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 ZZ PF00569.12 AIC16371.1 - 5.1 6.7 6.0 12 5.5 0.1 2.4 2 1 1 3 3 3 0 Zinc finger, ZZ type Fer4 PF00037.22 AIC16371.1 - 6.4 6.5 6.1 1.7 8.3 0.8 2.2 2 0 0 2 2 2 0 4Fe-4S binding domain zf-TFIIB PF13453.1 AIC16371.1 - 8.5 5.6 6.5 2e+02 1.3 4.5 2.1 1 1 0 1 1 1 0 Transcription factor zinc-finger AA_kinase PF00696.23 AIC16373.1 - 2.4e-23 82.9 0.4 4.5e-23 82.0 0.2 1.5 1 0 0 1 1 1 1 Amino acid kinase family Aminotran_4 PF01063.14 AIC16374.1 - 7.5e-48 163.0 0.0 8.8e-48 162.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class IV DUF3944 PF13099.1 AIC16374.1 - 0.11 11.9 1.3 0.12 11.9 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3944) COesterase PF00135.23 AIC16375.1 - 0.18 10.4 0.4 0.19 10.3 0.3 1.0 1 0 0 1 1 1 0 Carboxylesterase family PepSY_TM_3 PF13706.1 AIC16375.1 - 0.23 10.9 1.3 0.43 10.0 0.0 2.1 2 0 0 2 2 2 0 PepSY-associated TM helix MoCF_biosynth PF00994.19 AIC16376.1 - 1.1e-35 122.1 0.1 1.5e-35 121.7 0.0 1.2 1 0 0 1 1 1 1 Probable molybdopterin binding domain Metallophos_3 PF14582.1 AIC16376.1 - 0.02 14.0 0.2 2.3 7.3 0.1 2.1 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily eIF-6 PF01912.13 AIC16377.1 - 1.5e-65 220.0 0.1 1.7e-65 219.8 0.1 1.1 1 0 0 1 1 1 1 eIF-6 family IncA PF04156.9 AIC16378.1 - 0.0033 17.0 0.0 0.0039 16.8 0.0 1.1 1 0 0 1 1 1 1 IncA protein Protocadherin PF08374.6 AIC16378.1 - 0.0045 16.6 0.0 0.0052 16.4 0.0 1.0 1 0 0 1 1 1 1 Protocadherin TMEM51 PF15345.1 AIC16378.1 - 0.012 15.2 0.1 0.014 15.0 0.0 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4231 PF14015.1 AIC16378.1 - 0.074 13.0 0.3 0.1 12.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) NfeD PF01957.13 AIC16378.1 - 0.097 12.8 0.5 0.14 12.3 0.4 1.4 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding DUF2681 PF10883.3 AIC16378.1 - 0.54 10.5 5.9 1.2 9.4 4.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) F420_oxidored PF03807.12 AIC16379.1 - 1.2e-15 57.7 0.2 1.7e-15 57.2 0.1 1.2 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.10 AIC16379.1 - 9.1e-06 25.6 0.1 1.4e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_10 PF13460.1 AIC16379.1 - 0.014 15.4 0.1 0.018 15.0 0.1 1.3 1 0 0 1 1 1 0 NADH(P)-binding 2-Hacid_dh_C PF02826.14 AIC16379.1 - 0.02 14.0 0.1 0.029 13.5 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 AIC16379.1 - 0.023 14.0 0.1 0.085 12.2 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Rossmann-like PF10727.4 AIC16379.1 - 0.035 13.8 0.1 0.47 10.1 0.0 2.5 2 1 0 2 2 2 0 Rossmann-like domain 3HCDH_N PF02737.13 AIC16379.1 - 0.045 13.3 0.3 0.058 13.0 0.2 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.11 AIC16379.1 - 0.053 12.9 0.2 0.11 11.9 0.1 1.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA IlvN PF07991.7 AIC16379.1 - 0.092 12.1 0.1 0.16 11.3 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain MSV199 PF10553.4 AIC16380.1 - 0.071 12.9 0.1 0.071 12.9 0.1 1.1 1 0 0 1 1 1 0 MSV199 domain YcfA PF07927.7 AIC16382.1 - 1.7e-13 50.2 0.1 2.3e-13 49.8 0.1 1.2 1 0 0 1 1 1 1 YcfA-like protein UPF0150 PF03681.10 AIC16383.1 - 6e-20 70.6 0.4 7.5e-20 70.3 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0150) DUF3832 PF12909.2 AIC16383.1 - 0.00083 19.3 0.1 0.00094 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3832) GAS PF13851.1 AIC16383.1 - 0.032 13.4 0.1 0.037 13.2 0.1 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding COG2 PF06148.6 AIC16383.1 - 0.071 12.9 0.0 0.082 12.7 0.0 1.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF3160 PF11369.3 AIC16383.1 - 0.073 11.3 0.0 0.078 11.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) OTCace_N PF02729.16 AIC16384.1 - 2.2e-41 140.8 0.0 3.7e-41 140.0 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 AIC16384.1 - 5.1e-36 123.9 0.0 7.1e-36 123.4 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Methyltransf_3 PF01596.12 AIC16385.1 - 1.4e-35 122.2 0.0 1.8e-35 121.8 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.1 AIC16385.1 - 7.4e-17 62.1 0.0 1.2e-16 61.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC16385.1 - 2.7e-11 43.2 0.0 3.7e-11 42.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC16385.1 - 1.9e-10 41.3 0.1 2.8e-10 40.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC16385.1 - 4.8e-09 36.2 0.1 1.2e-08 35.0 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 AIC16385.1 - 6.1e-08 32.4 0.0 9.2e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 AIC16385.1 - 1e-05 24.9 0.0 1.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain GCD14 PF08704.5 AIC16385.1 - 6.4e-05 22.5 0.0 9.1e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit CmcI PF04989.7 AIC16385.1 - 0.00011 21.5 0.0 0.00018 20.8 0.0 1.3 1 1 0 1 1 1 1 Cephalosporin hydroxylase Methyltransf_11 PF08241.7 AIC16385.1 - 0.00024 21.5 0.0 0.00045 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC16385.1 - 0.0032 17.8 0.0 0.0049 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC16385.1 - 0.017 14.2 0.0 0.021 13.9 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family PrmA PF06325.8 AIC16385.1 - 0.028 13.5 0.1 0.037 13.1 0.1 1.3 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.10 AIC16385.1 - 0.045 13.1 0.1 0.15 11.4 0.0 1.8 2 0 0 2 2 2 0 Conserved hypothetical protein 95 UPF0020 PF01170.13 AIC16385.1 - 0.053 13.0 0.0 0.075 12.6 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 UPF0146 PF03686.8 AIC16385.1 - 0.072 12.9 0.6 1.1 9.1 0.1 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0146) Methyltransf_23 PF13489.1 AIC16385.1 - 0.1 12.3 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Antitoxin-MazE PF04014.13 AIC16387.1 - 2.6e-12 46.1 1.9 4e-12 45.5 1.3 1.3 1 0 0 1 1 1 1 Antidote-toxin recognition MazE Dak1_2 PF13684.1 AIC16387.1 - 0.0073 15.2 0.3 0.0088 15.0 0.2 1.0 1 0 0 1 1 1 1 Dihydroxyacetone kinase family DUF2375 PF09558.5 AIC16387.1 - 0.038 13.8 0.8 0.091 12.6 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2375) Rad60-SLD PF11976.3 AIC16387.1 - 0.059 13.0 0.2 0.54 9.9 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like PemK PF02452.12 AIC16388.1 - 3.5e-20 72.2 0.5 3.8e-20 72.1 0.3 1.0 1 0 0 1 1 1 1 PemK-like protein DDE_Tnp_IS240 PF13610.1 AIC16390.1 - 8.9e-10 38.6 0.0 1.4e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16390.1 - 2.3e-05 24.4 0.2 4.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC16390.1 - 0.00017 20.8 0.6 0.00033 19.9 0.3 1.6 1 1 0 1 1 1 1 Transposase IS66 family DUF4206 PF13901.1 AIC16390.1 - 0.029 13.9 0.7 0.04 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) PIN PF01850.16 AIC16391.1 - 2e-09 37.7 0.7 2.4e-09 37.5 0.5 1.1 1 0 0 1 1 1 1 PIN domain CcdA PF07362.7 AIC16392.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Post-segregation antitoxin CcdA PI31_Prot_N PF11566.3 AIC16392.1 - 0.015 14.8 0.0 0.016 14.7 0.0 1.1 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal RHH_1 PF01402.16 AIC16392.1 - 0.15 11.9 1.2 5.8 6.9 0.3 2.6 2 1 0 2 2 2 0 Ribbon-helix-helix protein, copG family RHH_3 PF12651.2 AIC16392.1 - 0.18 11.5 0.8 2.3 8.0 0.1 2.6 2 1 0 2 2 2 0 Ribbon-helix-helix domain HATPase_c PF02518.21 AIC16393.1 - 1.7e-31 108.1 0.0 4.5e-31 106.8 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 AIC16393.1 - 4.2e-14 52.2 3.1 6.1e-14 51.7 0.1 2.8 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain Cache_1 PF02743.13 AIC16393.1 - 3.6e-07 29.6 0.0 8.7e-07 28.4 0.0 1.6 1 0 0 1 1 1 1 Cache domain HATPase_c_5 PF14501.1 AIC16393.1 - 0.03 14.0 0.0 0.1 12.3 0.0 1.9 1 0 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.1 AIC16393.1 - 0.089 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Atg14 PF10186.4 AIC16393.1 - 0.97 8.3 6.6 0.43 9.4 2.7 1.7 2 0 0 2 2 2 0 UV radiation resistance protein and autophagy-related subunit 14 Rnk_N PF14760.1 AIC16393.1 - 1.8 8.7 4.5 3.9 7.6 0.4 2.6 2 0 0 2 2 2 0 Rnk N-terminus Response_reg PF00072.19 AIC16394.1 - 1.1e-21 76.8 0.1 1.3e-21 76.7 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.6 AIC16394.1 - 0.029 14.5 0.0 0.038 14.1 0.0 1.1 1 0 0 1 1 1 0 Flagellar regulatory protein FleQ Response_reg PF00072.19 AIC16395.1 - 1.9e-18 66.5 0.0 2.1e-18 66.3 0.0 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.6 AIC16395.1 - 0.0016 18.5 0.0 0.0023 18.0 0.0 1.2 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ Imm34 PF15596.1 AIC16395.1 - 0.13 12.4 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 34 HATPase_c PF02518.21 AIC16396.1 - 1.3e-26 92.5 0.0 3.3e-26 91.1 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.20 AIC16396.1 - 2.1e-17 63.0 0.4 2.1e-17 63.0 0.3 2.2 2 0 0 2 2 2 1 HAMP domain HisKA PF00512.20 AIC16396.1 - 7.7e-05 22.6 0.0 0.00019 21.3 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.1 AIC16396.1 - 9.4e-05 22.0 0.0 0.00023 20.7 0.0 1.7 1 0 0 1 1 1 1 GHKL domain HATPase_c_2 PF13581.1 AIC16396.1 - 0.0016 18.1 0.0 0.0044 16.8 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain DUF948 PF06103.6 AIC16396.1 - 0.54 10.1 5.6 0.97 9.3 1.3 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Peptidase_M10 PF00413.19 AIC16397.1 - 2.3e-06 27.4 0.1 4.6e-06 26.4 0.1 1.8 1 1 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.1 AIC16397.1 - 0.0034 17.8 0.0 0.0066 16.9 0.0 1.5 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.4 AIC16397.1 - 0.0044 15.9 0.2 0.0075 15.1 0.1 1.3 1 0 0 1 1 1 1 Peptidase M66 Reprolysin_4 PF13583.1 AIC16397.1 - 0.013 15.0 0.0 0.02 14.4 0.0 1.4 1 1 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like SOG2 PF10428.4 AIC16397.1 - 0.033 12.8 0.2 0.047 12.3 0.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Metallopep PF12044.3 AIC16397.1 - 0.09 11.2 0.0 0.15 10.4 0.0 1.3 1 0 0 1 1 1 0 Putative peptidase family Peptidase_M24 PF00557.19 AIC16397.1 - 0.098 12.2 0.1 11 5.5 0.0 2.2 2 0 0 2 2 2 0 Metallopeptidase family M24 Peptidase_M54 PF07998.6 AIC16397.1 - 0.1 12.3 0.1 0.37 10.5 0.0 1.9 1 1 1 2 2 2 0 Peptidase family M54 NTP_transf_5 PF14907.1 AIC16398.1 - 1.2e-06 28.0 0.0 1.6e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised nucleotidyltransferase DUF1814 PF08843.6 AIC16398.1 - 0.0044 16.8 0.0 0.0057 16.4 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF1814) DUF4095 PF13338.1 AIC16399.1 - 0.099 12.7 0.1 0.17 12.0 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4095) Antitoxin-MazE PF04014.13 AIC16401.1 - 0.022 14.4 0.0 0.039 13.6 0.0 1.4 1 0 0 1 1 1 0 Antidote-toxin recognition MazE DDE_Tnp_IS240 PF13610.1 AIC16403.1 - 6.8e-23 81.1 2.0 1.4e-22 80.1 1.4 1.5 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16403.1 - 1.9e-09 37.6 0.0 3.7e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain SWIM PF04434.12 AIC16403.1 - 0.00042 19.7 0.2 0.00093 18.6 0.2 1.6 1 0 0 1 1 1 1 SWIM zinc finger rve_3 PF13683.1 AIC16403.1 - 0.003 17.0 0.1 0.0095 15.4 0.1 1.9 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC16403.1 - 0.004 16.4 0.3 0.0066 15.6 0.2 1.4 1 0 0 1 1 1 1 Transposase IS66 family Zn_Tnp_IS1 PF03811.8 AIC16403.1 - 0.015 14.8 0.7 0.044 13.2 0.3 2.0 2 0 0 2 2 2 0 InsA N-terminal domain DDE_Tnp_ISL3 PF01610.12 AIC16403.1 - 0.036 13.6 1.0 0.062 12.8 0.7 1.3 1 0 0 1 1 1 0 Transposase Herpes_UL3 PF03369.8 AIC16403.1 - 0.15 11.9 0.9 2.1 8.3 0.0 2.5 2 1 0 2 2 2 0 Herpesvirus UL3 protein Cdc6_C PF09079.6 AIC16405.1 - 5.8e-13 48.3 0.5 1.2e-12 47.3 0.1 1.8 2 0 0 2 2 2 1 CDC6, C terminal AAA_22 PF13401.1 AIC16405.1 - 6.3e-08 32.8 0.0 2e-07 31.1 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AIC16405.1 - 3e-07 30.6 0.4 0.00046 20.2 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain AAA PF00004.24 AIC16405.1 - 1.7e-06 28.2 0.0 4.9e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Arch_ATPase PF01637.13 AIC16405.1 - 1.6e-05 24.7 0.5 9e-05 22.2 0.1 2.3 1 1 1 2 2 2 1 Archaeal ATPase AAA_17 PF13207.1 AIC16405.1 - 0.00092 20.0 0.0 0.0024 18.6 0.0 2.0 1 1 0 1 1 1 1 AAA domain NB-ARC PF00931.17 AIC16405.1 - 0.012 14.5 0.2 0.024 13.4 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain DUF815 PF05673.8 AIC16405.1 - 0.023 13.5 0.0 0.071 12.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.22 AIC16405.1 - 0.03 14.6 0.0 0.11 12.8 0.0 1.9 1 0 0 1 1 1 0 ABC transporter GTPase_Cys_C PF12631.2 AIC16405.1 - 0.037 14.4 0.2 0.52 10.7 0.1 2.8 3 0 0 3 3 3 0 Catalytic cysteine-containing C-terminus of GTPase, MnmE AAA_33 PF13671.1 AIC16405.1 - 0.054 13.3 0.0 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.17 AIC16405.1 - 0.14 12.3 0.0 0.45 10.7 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Fapy_DNA_glyco PF01149.19 AIC16406.1 - 0.024 15.0 0.3 0.096 13.0 0.0 1.9 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase N-terminal domain PIN PF01850.16 AIC16407.1 - 5.4e-15 55.8 0.7 5.9e-15 55.6 0.5 1.0 1 0 0 1 1 1 1 PIN domain DUF217 PF02697.9 AIC16408.1 - 1.9e-15 56.8 1.0 2.1e-15 56.7 0.7 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1753 Lipase_chap PF03280.9 AIC16408.1 - 0.011 15.2 0.1 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein NTP_transf_5 PF14907.1 AIC16411.1 - 0.00018 20.9 0.1 0.00059 19.2 0.0 1.7 1 1 0 1 1 1 1 Uncharacterised nucleotidyltransferase HTH_25 PF13413.1 AIC16413.1 - 0.046 13.3 0.2 0.17 11.5 0.1 2.1 1 0 0 1 1 1 0 Helix-turn-helix domain TMP_2 PF06791.8 AIC16413.1 - 0.095 12.3 7.2 0.02 14.4 2.2 2.0 2 0 0 2 2 2 0 Prophage tail length tape measure protein DASH_Dam1 PF08653.5 AIC16413.1 - 0.59 9.9 4.0 35 4.2 0.0 4.5 5 0 0 5 5 5 0 DASH complex subunit Dam1 Phasin_2 PF09361.5 AIC16413.1 - 2.3 8.2 12.8 0.18 11.8 0.6 3.4 2 1 1 3 3 3 0 Phasin protein Siah-Interact_N PF09032.6 AIC16413.1 - 3 7.9 13.8 2.3 8.3 0.6 4.0 4 0 0 4 4 4 0 Siah interacting protein, N terminal YgaB PF14182.1 AIC16413.1 - 5.1 7.4 14.6 9.6 6.5 1.7 4.4 3 2 1 5 5 5 0 YgaB-like protein WXG100 PF06013.7 AIC16413.1 - 9 6.3 15.2 5.2 7.1 0.5 3.5 3 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF2150 PF09920.4 AIC16414.1 - 0.014 14.9 0.6 0.022 14.3 0.2 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2150) DUF1464 PF07318.7 AIC16414.1 - 0.029 13.2 0.1 0.032 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) GrpE PF01025.14 AIC16414.1 - 0.031 13.8 1.5 0.035 13.6 1.1 1.2 1 0 0 1 1 1 0 GrpE HALZ PF02183.13 AIC16414.1 - 0.077 12.7 2.6 0.081 12.6 0.4 2.1 2 1 1 3 3 3 0 Homeobox associated leucine zipper RhoGEF PF00621.15 AIC16414.1 - 0.093 12.6 1.1 0.21 11.4 0.3 1.7 1 1 1 2 2 2 0 RhoGEF domain PIN_4 PF13638.1 AIC16414.1 - 0.12 12.4 0.9 0.13 12.3 0.6 1.2 1 0 0 1 1 1 0 PIN domain BMFP PF04380.8 AIC16414.1 - 0.13 12.4 1.0 0.63 10.2 0.2 2.2 2 0 0 2 2 2 0 Membrane fusogenic activity Lge1 PF11488.3 AIC16414.1 - 1.2 9.4 4.4 2.6 8.3 2.7 1.8 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 TSC22 PF01166.13 AIC16414.1 - 8.6 6.4 8.5 9.1 6.3 4.1 2.3 2 1 0 2 2 2 0 TSC-22/dip/bun family NTP_transf_2 PF01909.18 AIC16415.1 - 1.1e-07 32.0 0.6 2.4e-07 31.0 0.3 1.7 1 1 0 1 1 1 1 Nucleotidyltransferase domain HTH_27 PF13463.1 AIC16415.1 - 8.7e-06 25.9 0.0 2.7e-05 24.4 0.0 1.9 2 0 0 2 2 1 1 Winged helix DNA-binding domain Rrf2 PF02082.15 AIC16415.1 - 1e-05 25.5 0.0 2.3e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator TrmB PF01978.14 AIC16415.1 - 0.00053 19.6 0.0 0.0011 18.6 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB IF2_N PF04760.10 AIC16415.1 - 0.004 16.7 0.1 0.041 13.5 0.0 2.7 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region HTH_24 PF13412.1 AIC16415.1 - 0.0045 16.3 0.0 0.0098 15.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_20 PF12840.2 AIC16415.1 - 0.0046 16.7 0.3 0.014 15.2 0.1 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain DUF1495 PF07381.6 AIC16415.1 - 0.0092 15.6 0.1 0.076 12.6 0.1 2.2 1 1 0 1 1 1 1 Winged helix DNA-binding domain (DUF1495) GntR PF00392.16 AIC16415.1 - 0.013 14.8 0.0 0.042 13.2 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_IclR PF09339.5 AIC16415.1 - 0.014 14.9 0.1 0.024 14.2 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_5 PF01022.15 AIC16415.1 - 0.023 14.3 0.1 0.042 13.5 0.1 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family RPA_C PF08784.6 AIC16415.1 - 0.023 15.0 0.0 0.044 14.2 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal MarR_2 PF12802.2 AIC16415.1 - 0.024 14.2 0.0 0.051 13.2 0.0 1.6 1 0 0 1 1 1 0 MarR family DUF4423 PF14394.1 AIC16415.1 - 0.039 13.4 0.1 0.069 12.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) ANT PF03374.9 AIC16415.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.6 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain FeoC PF09012.5 AIC16415.1 - 0.073 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator HEPN PF05168.9 AIC16416.1 - 4e-09 36.3 0.4 5.4e-09 35.9 0.3 1.1 1 0 0 1 1 1 1 HEPN domain DUF4398 PF14346.1 AIC16416.1 - 0.0048 16.9 3.2 0.021 14.8 0.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4398) Peptidase_M15 PF01427.12 AIC16416.1 - 0.079 12.5 0.1 0.091 12.3 0.0 1.3 1 1 0 1 1 1 0 D-ala-D-ala dipeptidase Neur_chan_memb PF02932.11 AIC16417.1 - 7.5e-07 29.2 4.8 1.1e-06 28.7 3.4 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.18 AIC16417.1 - 0.011 14.9 0.1 0.13 11.4 0.0 2.2 1 1 0 2 2 2 0 Neurotransmitter-gated ion-channel ligand binding domain 60KD_IMP PF02096.15 AIC16417.1 - 0.13 11.8 3.3 0.24 11.0 2.2 1.4 1 1 0 1 1 1 0 60Kd inner membrane protein DUF459 PF04311.8 AIC16418.1 - 0.062 12.1 0.1 0.067 12.0 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF459) HTH_38 PF13936.1 AIC16419.1 - 0.00085 18.8 0.2 0.0025 17.3 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.1 AIC16419.1 - 0.016 14.5 0.0 0.052 12.9 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF977 PF06163.6 AIC16419.1 - 0.039 13.6 0.1 0.06 13.0 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF977) DDE_Tnp_IS1595 PF12762.2 AIC16421.1 - 2.7e-20 72.7 0.0 3.6e-20 72.3 0.0 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Polysacc_synt_C PF14667.1 AIC16422.1 - 1.3 8.8 6.3 1.1 8.9 1.0 2.1 2 0 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain Cpn60_TCP1 PF00118.19 AIC16423.1 - 3e-163 543.9 15.0 3.4e-163 543.7 10.4 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family HTH_20 PF12840.2 AIC16424.1 - 7.9e-16 57.6 0.9 4.7e-15 55.1 0.0 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC16424.1 - 5.9e-14 51.4 0.2 8.2e-12 44.6 0.0 2.6 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family TrmB PF01978.14 AIC16424.1 - 1.3e-08 34.3 1.6 0.00014 21.5 0.0 3.1 3 1 0 3 3 3 2 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC16424.1 - 1.8e-08 33.6 0.1 1.9e-06 27.1 0.0 2.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding PadR PF03551.9 AIC16424.1 - 4.1e-07 29.6 1.2 8.5e-06 25.4 0.1 2.8 2 1 0 2 2 2 1 Transcriptional regulator PadR-like family HTH_11 PF08279.7 AIC16424.1 - 2.6e-06 26.9 0.1 0.00016 21.2 0.0 2.8 2 0 0 2 2 2 1 HTH domain MarR_2 PF12802.2 AIC16424.1 - 4e-06 26.3 0.0 3.7e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 MarR family ArsR PF09824.4 AIC16424.1 - 0.00027 20.2 1.3 0.0045 16.3 0.1 2.5 1 1 1 2 2 2 1 ArsR transcriptional regulator MarR PF01047.17 AIC16424.1 - 0.00031 20.3 0.1 0.0014 18.3 0.0 2.1 2 0 0 2 2 2 1 MarR family DUF1495 PF07381.6 AIC16424.1 - 0.00051 19.6 0.1 0.29 10.8 0.0 2.8 2 1 0 2 2 2 1 Winged helix DNA-binding domain (DUF1495) DUF1759 PF03564.10 AIC16424.1 - 0.00058 19.6 2.0 0.00096 18.9 1.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) HxlR PF01638.12 AIC16424.1 - 0.0016 18.0 1.0 0.0045 16.5 0.0 2.2 3 1 1 4 4 2 1 HxlR-like helix-turn-helix HTH_12 PF08461.5 AIC16424.1 - 0.0024 17.5 0.3 0.01 15.5 0.0 2.3 2 1 0 2 2 1 1 Ribonuclease R winged-helix domain Rrf2 PF02082.15 AIC16424.1 - 0.0041 17.1 0.8 0.11 12.5 0.0 2.6 3 0 0 3 3 2 1 Transcriptional regulator HTH_34 PF13601.1 AIC16424.1 - 0.0071 16.3 0.5 0.044 13.8 0.0 2.2 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_Crp_2 PF13545.1 AIC16424.1 - 0.014 15.2 0.0 0.045 13.5 0.0 1.9 2 0 0 2 2 1 0 Crp-like helix-turn-helix domain HTH_AsnC-type PF13404.1 AIC16424.1 - 0.021 14.3 0.2 1 8.9 0.1 2.8 2 1 0 2 2 2 0 AsnC-type helix-turn-helix domain DUF1395 PF07160.7 AIC16424.1 - 0.022 14.2 1.8 0.055 12.9 0.6 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1395) DUF2250 PF10007.4 AIC16424.1 - 0.026 14.4 0.2 0.026 14.4 0.1 2.8 3 2 0 3 3 2 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_IclR PF09339.5 AIC16424.1 - 0.032 13.8 0.0 0.089 12.3 0.0 1.8 1 0 0 1 1 1 0 IclR helix-turn-helix domain Reo_sigmaC PF04582.7 AIC16424.1 - 0.032 13.4 0.7 0.046 12.9 0.5 1.2 1 0 0 1 1 1 0 Reovirus sigma C capsid protein HTH_27 PF13463.1 AIC16424.1 - 0.043 14.1 0.1 0.46 10.8 0.0 2.5 2 1 0 2 2 2 0 Winged helix DNA-binding domain DUF1082 PF06449.6 AIC16424.1 - 0.046 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial domain of unknown function (DUF1082) Sulfolobus_pRN PF05584.6 AIC16424.1 - 0.053 13.4 0.3 0.16 11.9 0.0 2.0 3 0 0 3 3 1 0 Sulfolobus plasmid regulatory protein Baculo_PEP_C PF04513.7 AIC16424.1 - 0.089 12.6 1.1 0.73 9.6 0.3 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HTH_29 PF13551.1 AIC16424.1 - 0.09 12.9 0.0 0.23 11.6 0.0 1.7 2 0 0 2 2 1 0 Winged helix-turn helix LexA_DNA_bind PF01726.11 AIC16424.1 - 0.11 12.1 0.0 0.42 10.2 0.0 2.0 2 0 0 2 2 2 0 LexA DNA binding domain FTA4 PF13093.1 AIC16424.1 - 0.14 11.5 5.7 0.22 10.9 3.8 1.3 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 BLOC1_2 PF10046.4 AIC16424.1 - 0.18 11.9 4.0 0.1 12.7 0.7 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_2 PF01920.15 AIC16424.1 - 0.26 11.0 3.9 0.49 10.1 0.3 2.7 2 1 0 2 2 2 0 Prefoldin subunit IncA PF04156.9 AIC16424.1 - 1.7 8.2 6.2 0.46 10.0 2.1 1.8 2 1 0 2 2 1 0 IncA protein DASH_Dam1 PF08653.5 AIC16424.1 - 1.7 8.4 3.8 2.8 7.7 0.4 2.5 2 0 0 2 2 2 0 DASH complex subunit Dam1 HSP20 PF00011.16 AIC16425.1 - 1.5e-09 37.5 1.6 4.2e-08 32.9 1.1 2.3 1 1 0 1 1 1 1 Hsp20/alpha crystallin family PIH1 PF08190.7 AIC16425.1 - 4.3e-07 29.6 0.0 5.3e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 pre-RNA processing PIH1/Nop17 CS PF04969.11 AIC16425.1 - 0.0067 16.9 0.6 0.037 14.5 0.2 2.2 2 1 1 3 3 3 1 CS domain BON PF04972.12 AIC16425.1 - 0.079 12.7 0.1 0.41 10.4 0.0 2.1 2 0 0 2 2 2 0 BON domain AAA PF00004.24 AIC16426.1 - 9.3e-100 330.0 0.0 4e-49 166.1 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 AIC16426.1 - 7.9e-23 80.2 0.1 2.5e-22 78.6 0.0 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 AIC16426.1 - 3.4e-17 62.8 0.0 2.2e-08 34.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 AIC16426.1 - 1.1e-14 54.0 0.0 1.7e-08 33.7 0.0 2.7 3 0 0 3 3 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_22 PF13401.1 AIC16426.1 - 5.4e-14 52.4 0.2 2.1e-05 24.6 0.0 4.0 2 2 0 2 2 2 2 AAA domain AAA_16 PF13191.1 AIC16426.1 - 1.5e-13 51.1 0.0 2e-06 27.9 0.0 3.1 2 1 1 3 3 3 2 AAA ATPase domain AAA_17 PF13207.1 AIC16426.1 - 2.2e-13 51.0 0.0 2.4e-06 28.3 0.0 2.8 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 AIC16426.1 - 2.8e-11 42.7 0.1 0.00037 19.3 0.0 3.2 3 0 0 3 3 3 2 TIP49 C-terminus AAA_5 PF07728.9 AIC16426.1 - 4.6e-11 42.6 0.4 0.00063 19.4 0.1 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.1 AIC16426.1 - 1.1e-10 41.5 0.0 0.00012 21.9 0.0 2.8 2 1 0 2 2 2 2 AAA domain Zeta_toxin PF06414.7 AIC16426.1 - 1.5e-10 40.5 0.0 0.00022 20.4 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_19 PF13245.1 AIC16426.1 - 2.7e-10 39.8 0.7 0.00074 19.2 0.1 2.7 2 0 0 2 2 2 2 Part of AAA domain CDC48_2 PF02933.12 AIC16426.1 - 4.7e-10 38.9 0.0 7.1e-09 35.1 0.0 2.7 3 0 0 3 3 3 1 Cell division protein 48 (CDC48), domain 2 AAA_14 PF13173.1 AIC16426.1 - 3.8e-09 36.5 0.0 0.00025 20.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.12 AIC16426.1 - 2.5e-08 33.5 0.2 0.0038 16.6 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.1 AIC16426.1 - 4.8e-08 33.3 0.9 0.0071 16.6 0.0 3.4 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.16 AIC16426.1 - 3.2e-07 29.7 1.0 0.011 14.8 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.1 AIC16426.1 - 4.1e-07 30.1 0.0 0.018 14.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.1 AIC16426.1 - 5.3e-07 29.2 6.8 0.065 12.6 0.3 4.3 2 2 0 3 3 3 3 AAA domain RNA_helicase PF00910.17 AIC16426.1 - 2.6e-06 27.5 0.0 0.092 12.9 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_3 PF07726.6 AIC16426.1 - 4.1e-06 26.4 0.0 0.11 12.1 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.21 AIC16426.1 - 4.6e-06 26.2 0.0 0.15 11.5 0.0 3.2 2 1 0 2 2 2 2 Sigma-54 interaction domain NACHT PF05729.7 AIC16426.1 - 8.4e-06 25.5 0.2 0.35 10.5 0.0 3.7 4 0 0 4 4 4 2 NACHT domain PhoH PF02562.11 AIC16426.1 - 2.6e-05 23.5 0.2 0.21 10.8 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein NTPase_1 PF03266.10 AIC16426.1 - 2.9e-05 23.8 2.4 1.1 9.0 0.0 4.0 2 1 1 3 3 3 2 NTPase NB-ARC PF00931.17 AIC16426.1 - 4.7e-05 22.3 0.1 0.15 10.9 0.0 2.7 3 0 0 3 3 3 2 NB-ARC domain AAA_11 PF13086.1 AIC16426.1 - 5e-05 23.0 0.1 0.3 10.6 0.0 2.4 1 1 1 2 2 2 2 AAA domain ResIII PF04851.10 AIC16426.1 - 5e-05 23.1 0.0 0.11 12.3 0.0 2.4 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit AAA_30 PF13604.1 AIC16426.1 - 6.5e-05 22.6 0.1 0.26 10.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain DUF2075 PF09848.4 AIC16426.1 - 9.9e-05 21.4 0.0 0.11 11.4 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) Arch_ATPase PF01637.13 AIC16426.1 - 0.0001 22.0 0.1 0.0095 15.6 0.0 3.0 2 1 1 3 3 3 1 Archaeal ATPase CPT PF07931.7 AIC16426.1 - 0.00011 21.9 0.2 0.54 9.8 0.0 3.3 3 1 0 3 3 3 2 Chloramphenicol phosphotransferase-like protein KaiC PF06745.8 AIC16426.1 - 0.00018 20.6 0.8 0.32 10.0 0.0 3.2 2 1 0 3 3 3 1 KaiC Sigma54_activ_2 PF14532.1 AIC16426.1 - 0.00024 21.1 0.0 1.1 9.3 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain T2SE PF00437.15 AIC16426.1 - 0.00031 19.7 0.0 0.57 9.0 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein Parvo_NS1 PF01057.12 AIC16426.1 - 0.00035 19.5 0.2 0.35 9.6 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ATP-synt_ab PF00006.20 AIC16426.1 - 0.0004 19.9 0.0 0.36 10.2 0.0 2.4 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain SKI PF01202.17 AIC16426.1 - 0.00057 19.7 0.2 1.2 8.9 0.0 3.1 3 0 0 3 3 3 1 Shikimate kinase ABC_tran PF00005.22 AIC16426.1 - 0.00057 20.1 0.0 2 8.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter DUF815 PF05673.8 AIC16426.1 - 0.00068 18.6 0.0 0.78 8.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) Bac_DnaA PF00308.13 AIC16426.1 - 0.00074 19.2 0.0 0.14 11.7 0.0 3.3 2 1 1 3 3 3 1 Bacterial dnaA protein Viral_helicase1 PF01443.13 AIC16426.1 - 0.0012 18.3 0.0 0.27 10.6 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AFG1_ATPase PF03969.11 AIC16426.1 - 0.0015 17.4 0.0 0.29 9.8 0.0 2.2 2 0 0 2 2 2 1 AFG1-like ATPase Torsin PF06309.6 AIC16426.1 - 0.0018 18.1 0.0 2.5 8.0 0.0 2.5 2 0 0 2 2 2 1 Torsin Cytidylate_kin2 PF13189.1 AIC16426.1 - 0.0021 18.0 0.0 0.62 9.9 0.0 2.6 2 0 0 2 2 2 1 Cytidylate kinase-like family UPF0079 PF02367.12 AIC16426.1 - 0.0024 17.5 0.0 2.8 7.5 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 AAA_24 PF13479.1 AIC16426.1 - 0.0054 16.3 0.7 2.6 7.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain Vps4_C PF09336.5 AIC16426.1 - 0.042 13.7 0.1 5.1 7.0 0.0 3.3 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain Guanylate_kin PF00625.16 AIC16426.1 - 0.052 12.9 0.6 13 5.2 0.0 3.5 4 1 1 5 5 3 0 Guanylate kinase MCM PF00493.18 AIC16426.1 - 0.062 12.0 0.0 4.6 5.9 0.0 2.5 2 0 0 2 2 2 0 MCM2/3/5 family DAP3 PF10236.4 AIC16426.1 - 0.1 11.5 0.0 4.5 6.0 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 KTI12 PF08433.5 AIC16426.1 - 0.14 11.3 0.0 18 4.3 0.0 2.4 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_23 PF13476.1 AIC16426.1 - 0.56 10.5 4.9 5.6 7.2 0.0 3.5 4 0 0 4 4 3 0 AAA domain MannoseP_isomer PF01050.13 AIC16427.1 - 1e-23 83.5 0.0 1.1e-23 83.4 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.6 AIC16427.1 - 5.9e-10 38.5 0.0 8.2e-10 38.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain FdtA PF05523.6 AIC16427.1 - 0.00017 21.0 0.0 0.00023 20.6 0.0 1.3 1 0 0 1 1 1 1 WxcM-like, C-terminal AraC_binding PF02311.14 AIC16427.1 - 0.0044 16.7 0.0 0.0078 15.9 0.0 1.4 1 1 0 1 1 1 1 AraC-like ligand binding domain DUF1498 PF07385.7 AIC16427.1 - 0.031 13.4 0.0 0.041 13.0 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1498) Cupin_6 PF12852.2 AIC16427.1 - 0.043 13.4 0.0 0.045 13.3 0.0 1.1 1 0 0 1 1 1 0 Cupin CENP-C_C PF11699.3 AIC16427.1 - 0.05 13.5 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like DUF4384 PF14326.1 AIC16427.1 - 0.054 13.3 0.0 0.095 12.5 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4384) Epimerase PF01370.16 AIC16428.1 - 1.1e-58 198.4 0.2 1.3e-58 198.2 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.14 AIC16428.1 - 3.4e-28 98.1 1.0 4.6e-28 97.7 0.7 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.12 AIC16428.1 - 1.1e-24 86.7 0.1 1.6e-24 86.3 0.1 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.10 AIC16428.1 - 8.9e-21 74.0 5.0 1.8e-19 69.7 3.4 2.5 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.7 AIC16428.1 - 7.2e-15 54.5 0.6 2.6e-10 39.6 0.0 2.2 1 1 1 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.1 AIC16428.1 - 3.1e-12 46.8 0.7 1e-11 45.2 0.5 1.7 1 1 0 1 1 1 1 NADH(P)-binding adh_short PF00106.20 AIC16428.1 - 4.4e-07 29.9 2.8 1e-06 28.7 2.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase Saccharop_dh PF03435.13 AIC16428.1 - 0.00017 20.6 1.3 0.00017 20.6 0.9 1.4 2 0 0 2 2 2 1 Saccharopine dehydrogenase NmrA PF05368.8 AIC16428.1 - 0.00037 19.8 3.9 0.0067 15.7 2.4 2.4 2 1 0 2 2 2 1 NmrA-like family Ldh_1_N PF00056.18 AIC16428.1 - 0.0018 18.0 0.2 0.0033 17.2 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain KR PF08659.5 AIC16428.1 - 0.0086 15.7 2.4 0.28 10.8 1.7 2.5 1 1 0 1 1 1 1 KR domain NAD_binding_3 PF03447.11 AIC16428.1 - 0.0087 16.4 0.5 0.015 15.6 0.3 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.9 AIC16428.1 - 0.028 13.7 0.3 0.051 12.9 0.2 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain APS_kinase PF01583.15 AIC16430.1 - 3.3e-55 186.0 0.0 3.9e-55 185.7 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_18 PF13238.1 AIC16430.1 - 5.9e-09 36.3 0.1 1e-08 35.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.1 AIC16430.1 - 6.3e-08 32.6 0.0 1.6e-07 31.2 0.0 1.7 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.5 AIC16430.1 - 2.6e-06 26.8 0.0 3.3e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.1 AIC16430.1 - 0.00012 22.8 0.2 0.0002 22.1 0.1 1.5 1 1 0 1 1 1 1 AAA domain cobW PF02492.14 AIC16430.1 - 0.00089 18.7 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.10 AIC16430.1 - 0.0019 17.9 0.0 0.0028 17.3 0.0 1.3 1 0 0 1 1 1 1 NTPase Zeta_toxin PF06414.7 AIC16430.1 - 0.002 17.2 0.0 0.0033 16.5 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin 6PF2K PF01591.13 AIC16430.1 - 0.0026 16.8 0.0 0.0035 16.4 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_22 PF13401.1 AIC16430.1 - 0.0027 17.8 0.0 0.0089 16.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain MobB PF03205.9 AIC16430.1 - 0.0071 16.0 0.0 0.017 14.8 0.0 1.6 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B NACHT PF05729.7 AIC16430.1 - 0.0093 15.6 0.1 0.015 14.9 0.0 1.3 1 0 0 1 1 1 1 NACHT domain KAP_NTPase PF07693.9 AIC16430.1 - 0.012 14.6 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain DUF2075 PF09848.4 AIC16430.1 - 0.015 14.3 0.0 0.018 14.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ArgK PF03308.11 AIC16430.1 - 0.017 13.8 0.0 0.038 12.7 0.0 1.6 1 1 1 2 2 2 0 ArgK protein T2SE PF00437.15 AIC16430.1 - 0.023 13.6 0.0 0.039 12.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.1 AIC16430.1 - 0.035 14.1 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.1 AIC16430.1 - 0.037 13.9 0.0 0.06 13.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain SKI PF01202.17 AIC16430.1 - 0.06 13.2 0.1 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Shikimate kinase RNA_helicase PF00910.17 AIC16430.1 - 0.085 13.0 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA helicase AAA_19 PF13245.1 AIC16430.1 - 0.087 12.5 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Part of AAA domain SRP54 PF00448.17 AIC16430.1 - 0.087 12.2 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Thymidylate_kin PF02223.12 AIC16430.1 - 0.1 11.9 0.1 0.27 10.5 0.0 1.7 2 0 0 2 2 2 0 Thymidylate kinase NB-ARC PF00931.17 AIC16430.1 - 0.1 11.4 0.0 0.16 10.8 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain ADK PF00406.17 AIC16430.1 - 0.1 12.4 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Adenylate kinase AAA_10 PF12846.2 AIC16430.1 - 0.11 11.9 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA-like domain AAA_5 PF07728.9 AIC16430.1 - 0.11 12.2 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MMR_HSR1 PF01926.18 AIC16430.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_28 PF13521.1 AIC16430.1 - 0.13 12.2 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.13 AIC16430.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Glyco_trans_1_4 PF13692.1 AIC16431.1 - 2.2e-15 56.9 0.0 4.4e-15 56.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.15 AIC16431.1 - 8.5e-15 54.5 0.0 1.4e-14 53.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.1 AIC16431.1 - 5.7e-14 52.5 0.0 1e-13 51.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.1 AIC16431.1 - 7e-11 42.2 0.0 1.9e-10 40.8 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_transf_4 PF13439.1 AIC16431.1 - 1.7e-10 40.9 0.0 6e-09 35.8 0.0 2.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_transf_5 PF08323.6 AIC16431.1 - 0.0045 16.5 0.0 0.01 15.3 0.0 1.6 1 1 0 1 1 1 1 Starch synthase catalytic domain Glyco_trans_4_2 PF13477.1 AIC16431.1 - 0.012 15.4 0.1 0.22 11.3 0.0 2.3 1 1 0 2 2 2 0 Glycosyl transferase 4-like Syntaxin-6_N PF09177.6 AIC16431.1 - 0.091 13.1 0.1 0.48 10.8 0.0 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal Sulfotransfer_1 PF00685.22 AIC16432.1 - 7e-13 48.4 0.1 1.1e-12 47.8 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.1 AIC16432.1 - 9.6e-06 26.6 0.0 3.9e-05 24.6 0.0 1.9 1 1 0 1 1 1 1 Sulfotransferase family B12D PF06522.6 AIC16432.1 - 0.006 16.2 0.0 0.01 15.5 0.0 1.4 1 0 0 1 1 1 1 NADH-ubiquinone reductase complex 1 MLRQ subunit Sulfotransfer_2 PF03567.9 AIC16432.1 - 0.12 12.0 0.0 2.2 7.9 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase family PMT_2 PF13231.1 AIC16433.1 - 6.7e-07 29.3 15.9 6.7e-07 29.3 11.0 5.5 3 3 1 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Acetyltransf_9 PF13527.1 AIC16434.1 - 2.4e-11 43.5 0.0 3.8e-11 42.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.1 AIC16434.1 - 0.011 15.8 0.1 0.062 13.4 0.0 2.2 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF3473 PF11959.3 AIC16435.1 - 1.5e-31 108.5 0.0 2.1e-31 108.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) Polysacc_deac_1 PF01522.16 AIC16435.1 - 2.4e-06 27.1 0.0 4e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Polysacc_synt_3 PF13440.1 AIC16436.1 - 1.7e-11 44.1 24.1 1.7e-11 44.1 16.7 2.1 2 0 0 2 2 2 2 Polysaccharide biosynthesis protein Polysacc_synt PF01943.12 AIC16436.1 - 3.3e-05 23.2 51.6 4.9e-05 22.7 22.3 3.1 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein Polysacc_synt_C PF14667.1 AIC16436.1 - 0.35 10.6 42.3 0.036 13.8 5.3 4.2 2 1 2 4 4 4 0 Polysaccharide biosynthesis C-terminal domain Glycos_transf_2 PF00535.21 AIC16437.1 - 5.7e-24 84.6 0.2 7.4e-24 84.3 0.2 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AIC16437.1 - 1.7e-10 41.0 0.0 4.2e-10 39.8 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.1 AIC16437.1 - 0.0029 16.8 0.0 0.01 15.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.1 AIC16437.1 - 0.021 15.1 0.0 0.037 14.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 DUF1129 PF06570.6 AIC16437.1 - 0.032 13.5 4.8 0.16 11.2 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) NTP_transf_3 PF12804.2 AIC16437.1 - 0.079 13.0 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 MobA-like NTP transferase domain Exo_endo_phos PF03372.18 AIC16442.1 - 1.8e-10 41.2 0.1 2.3e-10 40.8 0.1 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ParBc PF02195.13 AIC16444.1 - 1.3e-22 79.6 0.0 7.1e-22 77.3 0.0 2.2 2 0 0 2 2 2 1 ParB-like nuclease domain KorB PF08535.5 AIC16444.1 - 3e-06 27.2 1.0 6.1e-06 26.3 0.4 1.8 2 0 0 2 2 2 1 KorB domain Exo_endo_phos_2 PF14529.1 AIC16444.1 - 0.018 14.6 0.4 0.32 10.6 0.0 2.2 1 1 1 2 2 2 0 Endonuclease-reverse transcriptase SHMT PF00464.14 AIC16445.1 - 4.2e-72 242.7 0.1 4.2e-72 242.7 0.0 1.4 2 0 0 2 2 2 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.16 AIC16445.1 - 4e-06 26.1 0.0 7.4e-06 25.3 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.16 AIC16445.1 - 3e-05 23.1 0.0 8.5e-05 21.6 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II SelA PF03841.8 AIC16445.1 - 0.00098 17.9 0.0 0.0021 16.8 0.0 1.5 1 0 0 1 1 1 1 L-seryl-tRNA selenium transferase Halo_GVPC PF05465.8 AIC16445.1 - 0.17 11.8 0.1 0.17 11.8 0.0 2.4 3 0 0 3 3 3 0 Halobacterial gas vesicle protein C (GVPC) repeat Hist_deacetyl PF00850.14 AIC16446.1 - 1.5e-70 237.9 0.0 2e-70 237.5 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Lum_binding PF00677.12 AIC16447.1 - 2e-47 158.9 1.1 1.6e-25 88.8 0.1 2.0 2 0 0 2 2 2 2 Lumazine binding domain Antitoxin-MazE PF04014.13 AIC16447.1 - 0.015 14.9 0.6 6.5 6.5 0.0 3.3 3 0 0 3 3 3 0 Antidote-toxin recognition MazE Ldh_2 PF02615.9 AIC16447.1 - 0.096 11.3 0.0 0.16 10.6 0.0 1.3 1 0 0 1 1 1 0 Malate/L-lactate dehydrogenase DHBP_synthase PF00926.14 AIC16448.1 - 1.6e-63 213.4 0.8 1.8e-63 213.2 0.6 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase DMRL_synthase PF00885.14 AIC16449.1 - 4.3e-38 130.2 0.5 5.1e-38 129.9 0.4 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase DUF3866 PF12982.2 AIC16449.1 - 0.0091 14.9 0.1 0.0092 14.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3866) HSP70 PF00012.15 AIC16449.1 - 0.072 10.9 0.3 0.086 10.7 0.2 1.1 1 0 0 1 1 1 0 Hsp70 protein GGDN PF05165.7 AIC16450.1 - 4.9e-57 192.8 1.1 5.3e-57 192.6 0.8 1.0 1 0 0 1 1 1 1 GGDN family Guanylate_cyc PF00211.15 AIC16450.1 - 0.0041 16.5 0.2 0.0098 15.2 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Amidohydro_1 PF01979.15 AIC16451.1 - 5.4e-34 118.3 2.8 6.9e-34 117.9 2.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_4 PF13147.1 AIC16451.1 - 2.3e-13 50.8 3.4 2.3e-13 50.8 0.4 2.3 2 1 0 2 2 2 1 Amidohydrolase Amidohydro_3 PF07969.6 AIC16451.1 - 1.7e-11 44.0 8.1 8.4e-10 38.4 1.6 2.3 1 1 1 2 2 2 2 Amidohydrolase family Amidohydro_5 PF13594.1 AIC16451.1 - 3.5e-08 33.1 0.0 1.5e-07 31.1 0.0 2.2 1 1 0 1 1 1 1 Amidohydrolase DUF3420 PF11900.3 AIC16451.1 - 0.08 13.0 0.0 0.15 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) RibD_C PF01872.12 AIC16452.1 - 1.8e-48 164.8 1.8 2.1e-48 164.6 1.2 1.0 1 0 0 1 1 1 1 RibD C-terminal domain His_biosynth PF00977.16 AIC16452.1 - 0.009 15.2 0.9 1.9 7.7 0.1 2.1 1 1 0 2 2 2 2 Histidine biosynthesis protein Transposase_23 PF03017.9 AIC16452.1 - 0.037 13.5 0.3 0.22 11.0 0.0 2.1 1 1 1 2 2 2 0 TNP1/EN/SPM transposase Ala_racemase_C PF00842.16 AIC16452.1 - 0.11 11.9 0.0 0.23 10.8 0.0 1.5 1 0 0 1 1 1 0 Alanine racemase, C-terminal domain AAA_10 PF12846.2 AIC16453.1 - 1.6e-20 73.7 0.0 6.1e-20 71.8 0.0 1.9 1 1 0 1 1 1 1 AAA-like domain DUF87 PF01935.12 AIC16453.1 - 1.2e-14 54.6 8.3 4.6e-14 52.7 0.2 3.4 2 1 0 2 2 2 1 Domain of unknown function DUF87 DUF853 PF05872.7 AIC16453.1 - 1.6e-08 33.3 10.7 2.7e-08 32.6 0.0 3.3 3 0 0 3 3 3 1 Bacterial protein of unknown function (DUF853) FtsK_SpoIIIE PF01580.13 AIC16453.1 - 3.3e-05 23.4 0.1 3.3e-05 23.4 0.0 2.6 3 0 0 3 3 3 1 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.4 AIC16453.1 - 0.0005 18.8 0.0 0.0014 17.3 0.0 1.7 1 0 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.1 AIC16453.1 - 0.012 15.9 0.8 0.037 14.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.1 AIC16453.1 - 0.078 13.8 1.6 0.35 11.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.1 AIC16453.1 - 0.079 13.0 0.0 0.42 10.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.22 AIC16453.1 - 0.18 12.0 3.2 0.48 10.7 0.0 2.8 2 1 0 2 2 2 0 ABC transporter IncA PF04156.9 AIC16453.1 - 0.48 9.9 14.7 1.3 8.5 10.2 1.7 1 0 0 1 1 1 0 IncA protein DUF3508 PF12018.3 AIC16453.1 - 0.49 9.3 10.0 0.32 9.9 5.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3508) DUF3357 PF11837.3 AIC16454.1 - 0.012 15.4 0.5 0.013 15.3 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DUF1180 PF06679.7 AIC16454.1 - 0.014 15.3 1.9 0.015 15.2 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF2189 PF09955.4 AIC16454.1 - 0.019 14.8 0.2 0.023 14.6 0.1 1.1 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2189) DUF1628 PF07790.6 AIC16454.1 - 0.029 15.1 0.3 0.04 14.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1628) MARVEL PF01284.18 AIC16454.1 - 0.033 13.9 0.2 0.038 13.7 0.1 1.1 1 0 0 1 1 1 0 Membrane-associating domain Myco_19_kDa PF05481.7 AIC16454.1 - 0.046 13.5 1.8 0.058 13.2 1.2 1.2 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen TPT PF03151.11 AIC16454.1 - 0.049 13.2 0.3 0.055 13.1 0.2 1.1 1 0 0 1 1 1 0 Triose-phosphate Transporter family DUF4366 PF14283.1 AIC16454.1 - 0.21 11.0 0.8 0.23 10.8 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Myf5 PF12232.3 AIC16454.1 - 0.34 11.5 3.2 0.57 10.8 2.2 1.3 1 0 0 1 1 1 0 Myogenic determination factor 5 HTH_45 PF14947.1 AIC16455.1 - 6.7e-09 35.4 0.1 8.9e-09 35.0 0.1 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.17 AIC16455.1 - 0.0016 18.0 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 MarR family PadR PF03551.9 AIC16455.1 - 0.0022 17.7 0.0 0.0036 17.0 0.0 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.1 AIC16455.1 - 0.015 15.2 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain TrmB PF01978.14 AIC16455.1 - 0.016 14.8 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.1 AIC16455.1 - 0.028 14.7 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain DUF505 PF04458.7 AIC16455.1 - 0.029 12.5 0.0 0.032 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) DUF2250 PF10007.4 AIC16455.1 - 0.072 12.9 0.1 0.11 12.3 0.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) Peroxin-13_N PF04088.8 AIC16456.1 - 0.0033 17.3 0.2 0.0063 16.4 0.1 1.5 1 1 1 2 2 2 1 Peroxin 13, N-terminal region DUF2207 PF09972.4 AIC16456.1 - 0.007 15.0 0.3 0.0082 14.7 0.2 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF2142 PF09913.4 AIC16456.1 - 0.0091 14.7 0.6 0.011 14.4 0.4 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2142) DUF1049 PF06305.6 AIC16456.1 - 0.018 14.4 0.1 0.018 14.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) DUF4277 PF14104.1 AIC16456.1 - 0.027 14.6 0.1 0.042 14.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4277) DUF2458 PF10454.4 AIC16456.1 - 0.079 12.8 2.4 3.4 7.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2458) Lipase_chap PF03280.9 AIC16456.1 - 0.085 12.3 1.1 0.6 9.6 0.8 1.9 2 0 0 2 2 2 0 Proteobacterial lipase chaperone protein DUF2633 PF11119.3 AIC16456.1 - 0.085 12.5 0.4 0.19 11.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2633) DivIC PF04977.10 AIC16456.1 - 0.13 11.7 0.6 0.29 10.6 0.5 1.6 1 1 0 1 1 1 0 Septum formation initiator ABC2_membrane_2 PF12679.2 AIC16456.1 - 1.3 7.8 5.5 1.6 7.5 3.8 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF2976 PF11190.3 AIC16456.1 - 1.7 8.1 9.9 0.45 10.0 3.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2976) Cupredoxin_1 PF13473.1 AIC16457.1 - 5.2e-08 32.7 0.1 7e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 AIC16457.1 - 0.0039 17.3 0.5 0.0079 16.4 0.3 1.5 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family COX2 PF00116.15 AIC16457.1 - 0.082 12.7 0.1 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, periplasmic domain Aldedh PF00171.17 AIC16458.1 - 3.1e-149 497.2 0.1 4e-149 496.8 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.9 AIC16458.1 - 0.0021 16.8 0.0 0.0055 15.4 0.0 1.6 1 1 0 1 1 1 1 Acyl-CoA reductase (LuxC) Pro_dh PF01619.13 AIC16459.1 - 3.7e-38 131.2 0.0 9.1e-38 129.9 0.0 1.6 1 1 0 1 1 1 1 Proline dehydrogenase TusA PF01206.12 AIC16459.1 - 0.066 12.8 0.0 0.22 11.1 0.0 1.8 2 0 0 2 2 2 0 Sulfurtransferase TusA MarR PF01047.17 AIC16460.1 - 1.3e-14 53.6 0.0 2.5e-14 52.6 0.0 1.5 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.2 AIC16460.1 - 2.1e-11 43.2 0.0 3.2e-11 42.7 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 AIC16460.1 - 5.7e-06 26.5 0.0 1.1e-05 25.6 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.1 AIC16460.1 - 1.4e-05 24.3 0.0 5.7e-05 22.4 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_IclR PF09339.5 AIC16460.1 - 0.0012 18.4 0.0 0.0027 17.2 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_34 PF13601.1 AIC16460.1 - 0.002 18.0 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain CK2S PF15011.1 AIC16460.1 - 0.04 13.6 0.1 0.065 13.0 0.1 1.4 1 0 0 1 1 1 0 Casein Kinase 2 substrate HTH_36 PF13730.1 AIC16460.1 - 0.14 12.3 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain YqzE PF14038.1 AIC16460.1 - 0.24 11.1 1.3 1.4 8.7 0.5 2.2 2 0 0 2 2 2 0 YqzE-like protein DNA_binding_1 PF01035.15 AIC16462.1 - 2.2e-31 107.4 2.0 3.1e-30 103.7 0.2 2.5 2 1 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Ada_Zn_binding PF02805.11 AIC16462.1 - 2.3e-30 103.9 6.6 2.7e-30 103.7 3.5 1.9 2 0 0 2 2 2 1 Metal binding domain of Ada HTH_18 PF12833.2 AIC16462.1 - 1.2e-17 63.7 0.6 7.8e-17 61.1 0.3 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.18 AIC16462.1 - 2.7e-13 49.2 0.0 2.3e-08 33.5 0.0 2.8 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Methyltransf_1N PF02870.10 AIC16462.1 - 0.0047 17.4 0.0 0.012 16.1 0.0 1.7 2 0 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain TetR_N PF00440.18 AIC16462.1 - 0.093 12.3 0.1 0.36 10.5 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Inositol_P PF00459.20 AIC16463.1 - 3.6e-32 111.7 0.1 4.3e-32 111.5 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.15 AIC16463.1 - 6.6e-07 28.4 0.0 3.3e-06 26.1 0.0 1.8 2 0 0 2 2 2 1 Fructose-1-6-bisphosphatase PDZ_2 PF13180.1 AIC16465.1 - 0.0094 15.8 0.0 0.046 13.6 0.0 2.1 2 1 0 2 2 2 1 PDZ domain DUF790 PF05626.6 AIC16468.1 - 3.1e-90 302.4 0.0 1.4e-75 254.2 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF790) ResIII PF04851.10 AIC16469.1 - 1.4e-24 86.8 0.2 1.6e-23 83.4 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.26 AIC16469.1 - 4.1e-14 52.1 0.0 8.8e-14 51.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.24 AIC16469.1 - 9.9e-11 41.4 0.0 2.3e-10 40.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase SNF2_N PF00176.18 AIC16469.1 - 0.00018 20.3 0.0 0.00069 18.4 0.0 1.8 1 1 1 2 2 2 1 SNF2 family N-terminal domain Ammonium_transp PF00909.16 AIC16471.1 - 3.8e-116 387.8 34.5 4.6e-116 387.5 23.9 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family PepSY PF03413.14 AIC16474.1 - 0.00083 19.9 0.1 0.002 18.7 0.1 1.6 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain HTH_45 PF14947.1 AIC16475.1 - 2.2e-09 36.9 0.5 2.8e-09 36.6 0.3 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix PadR PF03551.9 AIC16475.1 - 0.00047 19.8 0.0 0.00085 19.0 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.1 AIC16475.1 - 0.003 17.5 0.1 0.0037 17.2 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.17 AIC16475.1 - 0.016 14.9 0.0 0.024 14.3 0.0 1.3 1 0 0 1 1 1 0 MarR family DUF505 PF04458.7 AIC16475.1 - 0.065 11.3 0.2 0.072 11.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF505) DUF3051 PF11252.3 AIC16475.1 - 0.075 12.5 0.0 0.089 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) TrmB PF01978.14 AIC16475.1 - 0.091 12.4 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF4231 PF14015.1 AIC16476.1 - 0.0072 16.3 0.8 0.94 9.4 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF4231) DUF4064 PF13273.1 AIC16476.1 - 0.43 10.7 2.6 0.52 10.4 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) DUF45 PF01863.12 AIC16477.1 - 2.5e-52 177.6 1.1 2.9e-52 177.4 0.8 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.5 AIC16477.1 - 0.00016 21.6 1.6 0.00033 20.5 1.1 1.4 1 0 0 1 1 1 1 WLM domain SprT-like PF10263.4 AIC16477.1 - 0.004 16.8 0.1 0.0068 16.0 0.0 1.4 1 0 0 1 1 1 1 SprT-like family Peptidase_M56 PF05569.6 AIC16477.1 - 0.071 12.0 1.1 0.15 10.9 0.8 1.5 1 0 0 1 1 1 0 BlaR1 peptidase M56 HSDR_N PF04313.9 AIC16478.1 - 1.4e-30 106.5 0.9 7.1e-30 104.2 0.1 2.5 2 0 0 2 2 2 1 Type I restriction enzyme R protein N terminus (HSDR_N) ResIII PF04851.10 AIC16478.1 - 9.1e-17 61.4 0.7 3.4e-16 59.6 0.5 2.0 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF3387 PF11867.3 AIC16478.1 - 9.4e-13 47.8 11.4 1.8e-12 46.8 7.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3387) DEAD PF00270.24 AIC16478.1 - 0.0004 19.9 0.1 0.0024 17.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF2075 PF09848.4 AIC16478.1 - 0.0045 16.0 0.6 0.03 13.3 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) DUF1160 PF06648.6 AIC16478.1 - 0.0056 16.4 0.7 0.19 11.5 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1160) DUF3395 PF11875.3 AIC16478.1 - 0.0076 15.8 0.4 0.038 13.6 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) HSDR_N_2 PF13588.1 AIC16478.1 - 0.013 15.2 0.0 0.04 13.7 0.0 1.9 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) AAA_22 PF13401.1 AIC16478.1 - 0.02 15.0 0.1 0.22 11.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain Helicase_C PF00271.26 AIC16478.1 - 0.039 13.8 0.0 0.25 11.2 0.0 2.4 1 1 0 1 1 1 0 Helicase conserved C-terminal domain Methylase_S PF01420.14 AIC16479.1 - 1.2e-32 113.2 1.5 1.5e-17 64.0 0.0 2.2 2 0 0 2 2 2 2 Type I restriction modification DNA specificity domain N6_Mtase PF02384.11 AIC16480.1 - 4.1e-107 357.8 0.1 1.4e-106 356.0 0.0 1.7 2 0 0 2 2 2 1 N-6 DNA Methylase HsdM_N PF12161.3 AIC16480.1 - 4.3e-30 104.9 0.3 4.3e-30 104.9 0.2 2.5 3 1 0 3 3 3 1 HsdM N-terminal domain Methyltransf_26 PF13659.1 AIC16480.1 - 2.9e-07 30.5 0.0 1.9e-06 27.8 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain UPF0020 PF01170.13 AIC16480.1 - 1.2e-06 28.2 0.0 2.4e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.9 AIC16480.1 - 0.0035 16.7 0.0 0.0082 15.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Mdv1 PF11542.3 AIC16480.1 - 0.043 13.7 0.8 8.9 6.3 0.1 2.7 2 0 0 2 2 2 0 Mitochondrial division protein 1 GP46 PF07409.7 AIC16481.1 - 0.056 12.7 0.1 0.068 12.4 0.0 1.1 1 0 0 1 1 1 0 Phage protein GP46 HxlR PF01638.12 AIC16482.1 - 5e-28 96.5 1.1 6.1e-28 96.2 0.8 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.9 AIC16482.1 - 0.0023 17.6 0.1 0.0042 16.8 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.1 AIC16482.1 - 0.014 15.4 0.1 0.024 14.6 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR PF01047.17 AIC16482.1 - 0.044 13.5 0.3 0.085 12.5 0.2 1.5 1 0 0 1 1 1 0 MarR family HTH_20 PF12840.2 AIC16482.1 - 0.063 13.0 0.1 0.11 12.3 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_24 PF13412.1 AIC16482.1 - 0.085 12.2 1.0 0.15 11.4 0.7 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Proteasome PF00227.21 AIC16483.1 - 5.9e-41 139.8 0.0 6.9e-41 139.6 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Proteasome PF00227.21 AIC16484.1 - 1.2e-48 164.9 0.8 1.3e-48 164.7 0.6 1.0 1 0 0 1 1 1 1 Proteasome subunit DUF2250 PF10007.4 AIC16486.1 - 7.1e-06 25.8 0.0 0.00017 21.4 0.1 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) MarR PF01047.17 AIC16486.1 - 8.8e-06 25.3 0.1 2.1e-05 24.1 0.0 1.6 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.2 AIC16486.1 - 5.5e-05 22.7 0.0 0.00018 21.1 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.1 AIC16486.1 - 0.0014 17.9 0.0 0.0029 16.9 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Rrf2 PF02082.15 AIC16486.1 - 0.0055 16.8 0.1 0.093 12.8 0.1 2.4 2 0 0 2 2 2 1 Transcriptional regulator HTH_20 PF12840.2 AIC16486.1 - 0.0057 16.4 1.2 0.011 15.4 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.14 AIC16486.1 - 0.007 16.0 0.0 0.023 14.3 0.0 1.9 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.15 AIC16486.1 - 0.013 15.1 0.3 0.031 13.9 0.2 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family GntR PF00392.16 AIC16486.1 - 0.029 13.8 0.1 0.087 12.2 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family PaaX PF07848.7 AIC16486.1 - 0.039 13.9 0.1 0.074 13.0 0.1 1.5 1 0 0 1 1 1 0 PaaX-like protein RPA_C PF08784.6 AIC16486.1 - 0.041 14.2 0.9 0.09 13.1 0.7 1.5 1 0 0 1 1 1 0 Replication protein A C terminal HTH_23 PF13384.1 AIC16486.1 - 0.05 13.2 1.0 4.6 7.0 0.3 2.6 1 1 1 2 2 2 0 Homeodomain-like domain FeoC PF09012.5 AIC16486.1 - 0.053 13.2 0.1 0.15 11.7 0.1 1.8 1 0 0 1 1 1 0 FeoC like transcriptional regulator HTH_11 PF08279.7 AIC16486.1 - 0.054 13.1 0.1 0.28 10.8 0.0 2.2 2 0 0 2 2 2 0 HTH domain Fe_dep_repress PF01325.14 AIC16486.1 - 0.11 12.4 0.1 0.6 10.0 0.0 2.0 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain zf-met PF12874.2 AIC16487.1 - 0.00058 19.9 1.3 0.00081 19.5 0.9 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF629 PF04780.7 AIC16487.1 - 0.0013 17.3 0.0 0.0013 17.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF629) zf-C2H2_4 PF13894.1 AIC16487.1 - 0.0014 18.8 0.3 0.0017 18.5 0.2 1.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC16487.1 - 0.0034 17.6 0.4 0.0043 17.3 0.3 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.1 AIC16487.1 - 0.0064 16.3 0.4 0.0089 15.9 0.2 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.3 AIC16487.1 - 0.0068 16.5 0.5 0.011 15.8 0.3 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding DUF4451 PF14616.1 AIC16487.1 - 0.034 13.9 0.6 0.045 13.5 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) UPF0150 PF03681.10 AIC16488.1 - 2.1e-12 46.4 0.1 2.9e-12 45.9 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0150) DUF1902 PF08972.6 AIC16488.1 - 0.00023 20.6 0.0 0.00029 20.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1902) APP_E2 PF12925.2 AIC16488.1 - 0.05 13.1 0.1 0.062 12.8 0.1 1.1 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein YcfA PF07927.7 AIC16489.1 - 1.1e-18 66.8 0.5 1.4e-18 66.5 0.3 1.1 1 0 0 1 1 1 1 YcfA-like protein Hjc PF01870.13 AIC16489.1 - 0.045 13.3 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Archaeal holliday junction resolvase (hjc) TrmB PF01978.14 AIC16490.1 - 0.1 12.2 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF1027 PF06265.6 AIC16491.1 - 0.0018 18.0 1.6 0.84 9.5 0.1 2.7 2 0 0 2 2 2 2 Protein of unknown function (DUF1027) DUF2250 PF10007.4 AIC16491.1 - 0.012 15.5 0.5 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) SUI1 PF01253.17 AIC16492.1 - 5.5e-17 61.3 0.1 6.7e-17 61.0 0.1 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 Trypsin_2 PF13365.1 AIC16493.1 - 1.7e-24 86.0 0.8 2.9e-24 85.3 0.6 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.1 AIC16493.1 - 1.3e-16 60.1 0.1 3.7e-15 55.5 0.0 2.5 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.21 AIC16493.1 - 3.8e-14 52.8 0.0 7e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin PDZ PF00595.19 AIC16493.1 - 2e-05 24.6 0.1 0.00013 22.0 0.0 2.3 2 0 0 2 2 2 1 PDZ domain (Also known as DHR or GLGF) Peptidase_S46 PF10459.4 AIC16493.1 - 0.002 16.6 0.5 0.6 8.4 0.2 2.1 2 0 0 2 2 2 2 Peptidase S46 Tricorn_PDZ PF14685.1 AIC16493.1 - 0.0053 16.5 0.1 0.02 14.7 0.0 2.0 2 0 0 2 2 2 1 Tricorn protease PDZ domain FMN_red PF03358.10 AIC16494.1 - 3.1e-30 104.7 0.1 3.6e-30 104.4 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 AIC16494.1 - 1.9e-10 40.6 0.0 2.1e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.2 AIC16494.1 - 0.051 13.5 0.0 0.095 12.6 0.0 1.5 2 0 0 2 2 2 0 Flavodoxin domain Pirin PF02678.11 AIC16495.1 - 2.8e-34 117.1 0.9 5.5e-34 116.2 0.6 1.5 1 0 0 1 1 1 1 Pirin Cupin_2 PF07883.6 AIC16495.1 - 5.5e-09 35.3 2.4 1.7e-07 30.6 0.4 2.8 3 1 1 4 4 4 2 Cupin domain Pirin_C PF05726.8 AIC16495.1 - 0.0003 20.7 0.1 0.031 14.3 0.0 2.3 2 0 0 2 2 2 2 Pirin C-terminal cupin domain MS_channel PF00924.13 AIC16496.1 - 1.2e-07 31.3 1.6 3.3e-07 29.8 1.1 1.6 1 1 0 1 1 1 1 Mechanosensitive ion channel zf-CSL PF05207.8 AIC16497.1 - 8.2e-05 22.0 1.9 9.5e-05 21.8 1.3 1.1 1 0 0 1 1 1 1 CSL zinc finger Zn_Tnp_IS1595 PF12760.2 AIC16497.1 - 0.00098 18.8 2.1 0.0012 18.6 1.5 1.2 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Lar_restr_allev PF14354.1 AIC16497.1 - 0.0027 17.9 3.4 0.0038 17.4 2.4 1.3 1 1 0 1 1 1 1 Restriction alleviation protein Lar Cys_rich_CPXG PF14255.1 AIC16497.1 - 0.0096 15.7 0.2 0.011 15.4 0.2 1.1 1 0 0 1 1 1 1 Cysteine-rich CPXCG DUF2072 PF09845.4 AIC16497.1 - 0.022 14.6 0.4 0.029 14.2 0.3 1.3 1 1 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) TF_Zn_Ribbon PF08271.7 AIC16497.1 - 0.033 13.5 2.2 0.054 12.8 1.5 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding Elf1 PF05129.8 AIC16497.1 - 0.033 13.8 1.7 0.034 13.8 1.2 1.1 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DZR PF12773.2 AIC16497.1 - 0.034 13.9 1.2 0.044 13.5 0.8 1.3 1 0 0 1 1 1 0 Double zinc ribbon RNA_POL_M_15KD PF02150.11 AIC16497.1 - 0.05 13.3 2.5 0.34 10.6 1.8 2.0 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit tRNA-synt_1f PF01921.13 AIC16497.1 - 0.052 12.2 0.1 0.055 12.1 0.1 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (K) zf-DNL PF05180.7 AIC16497.1 - 0.057 13.1 2.1 0.066 12.9 1.4 1.1 1 0 0 1 1 1 0 DNL zinc finger NMD3 PF04981.8 AIC16497.1 - 0.077 12.1 1.3 0.086 11.9 0.9 1.0 1 0 0 1 1 1 0 NMD3 family zinc_ribbon_5 PF13719.1 AIC16497.1 - 0.082 12.5 2.6 0.16 11.5 1.8 1.5 1 1 0 1 1 1 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.7 AIC16497.1 - 0.086 12.9 4.0 0.14 12.2 2.8 1.4 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase TFIIS_C PF01096.13 AIC16497.1 - 0.1 12.2 2.2 0.68 9.6 1.5 2.0 1 1 0 1 1 1 0 Transcription factor S-II (TFIIS) DUF2387 PF09526.5 AIC16497.1 - 0.11 12.4 1.6 0.13 12.2 1.1 1.1 1 0 0 1 1 1 0 Probable metal-binding protein (DUF2387) DUF4503 PF14951.1 AIC16497.1 - 0.12 10.4 0.6 0.13 10.4 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4503) zinc_ribbon_4 PF13717.1 AIC16497.1 - 0.28 10.9 2.7 0.57 9.9 1.9 1.6 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 AIC16497.1 - 0.54 10.2 6.0 0.87 9.5 0.8 2.1 1 1 1 2 2 2 0 Zinc ribbon domain HypA PF01155.14 AIC16497.1 - 0.68 9.6 2.6 3.5 7.3 0.1 2.0 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family zf-ribbon_3 PF13248.1 AIC16497.1 - 1.5 8.0 5.2 4.3 6.6 1.5 2.5 2 1 0 2 2 2 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.8 AIC16497.1 - 1.8 8.0 4.8 19 4.8 3.3 2.1 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Sgf11 PF08209.6 AIC16497.1 - 2.1 7.6 6.3 0.74 9.1 0.1 2.2 2 1 0 2 2 2 0 Sgf11 (transcriptional regulation protein) Zn_Tnp_IS1 PF03811.8 AIC16497.1 - 8.6 5.9 6.5 4.4 6.8 0.1 2.3 2 1 0 2 2 2 0 InsA N-terminal domain CTP_transf_2 PF01467.21 AIC16498.1 - 2.6e-16 60.0 0.0 3.4e-16 59.6 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase HIGH_NTase1 PF05636.6 AIC16498.1 - 0.0024 16.9 0.0 0.066 12.2 0.0 2.0 2 0 0 2 2 2 1 HIGH Nucleotidyl Transferase Citrate_ly_lig PF08218.6 AIC16498.1 - 0.0028 17.1 0.0 0.077 12.4 0.0 2.3 2 1 0 2 2 2 1 Citrate lyase ligase C-terminal domain Peripla_BP_1 PF00532.16 AIC16498.1 - 0.046 12.9 0.0 0.072 12.2 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family tRNA-synt_1g PF09334.6 AIC16499.1 - 1e-132 442.5 0.1 1.3e-132 442.2 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 AIC16499.1 - 8.1e-18 63.7 0.5 3.3e-08 32.0 0.0 3.9 2 2 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 AIC16499.1 - 3.7e-13 49.5 0.5 5.7e-13 48.8 0.4 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 AIC16499.1 - 1.2e-10 41.0 0.1 0.00021 20.5 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 AIC16499.1 - 0.00018 20.3 0.0 0.12 11.0 0.0 3.2 3 0 0 3 3 3 1 tRNA synthetases class I (K) zf-ribbon_3 PF13248.1 AIC16499.1 - 0.0067 15.6 5.0 0.55 9.5 3.5 2.4 1 1 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 AIC16499.1 - 0.39 10.5 5.2 0.79 9.5 3.6 1.5 1 0 0 1 1 1 0 Double zinc ribbon Ribosomal_L37e PF01907.14 AIC16499.1 - 3 7.7 5.8 3.3 7.5 1.1 2.6 3 0 0 3 3 3 0 Ribosomal protein L37e AdoHcyase_NAD PF00670.16 AIC16500.1 - 6.1e-50 169.2 0.1 1.3e-49 168.1 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.12 AIC16500.1 - 3.5e-49 167.1 0.0 4.8e-49 166.7 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.14 AIC16500.1 - 8.1e-10 38.1 0.0 1.9e-09 36.9 0.0 1.6 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 AIC16500.1 - 0.00012 21.6 0.5 0.00031 20.3 0.3 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain IlvN PF07991.7 AIC16500.1 - 0.00019 20.8 0.0 0.00044 19.6 0.0 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, catalytic domain TrkA_N PF02254.13 AIC16500.1 - 0.0015 18.5 0.0 0.0041 17.1 0.0 1.8 1 0 0 1 1 1 1 TrkA-N domain ABC2_membrane_2 PF12679.2 AIC16501.1 - 0.0058 15.5 0.1 0.0076 15.1 0.1 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein Rieske PF00355.21 AIC16502.1 - 2.5e-14 52.6 0.0 2.6e-14 52.5 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 AIC16502.1 - 2.6e-12 46.3 0.0 2.8e-12 46.2 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain tRNA-synt_1e PF01406.14 AIC16503.1 - 1.3e-123 411.9 0.2 4.4e-123 410.2 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.6 AIC16503.1 - 2.5e-14 52.7 1.2 1.1e-06 27.6 0.2 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.17 AIC16503.1 - 3.6e-08 31.8 0.1 1.2e-05 23.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.6 AIC16503.1 - 8.5e-08 32.3 2.1 2.2e-07 31.0 1.0 2.2 2 0 0 2 2 2 1 DALR domain tRNA-synt_1f PF01921.13 AIC16503.1 - 6.3e-06 25.1 0.1 0.0087 14.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) tRNA-synt_1d PF00750.14 AIC16503.1 - 0.023 13.5 0.1 0.48 9.1 0.0 2.3 2 0 0 2 2 2 0 tRNA synthetases class I (R) HDOD PF08668.7 AIC16503.1 - 0.032 13.4 0.1 0.3 10.3 0.0 2.3 1 1 1 2 2 2 0 HDOD domain Bactofilin PF04519.8 AIC16504.1 - 0.002 18.1 6.1 0.0079 16.1 3.2 2.0 1 1 1 2 2 2 2 Polymer-forming cytoskeletal GTP_EFTU_D4 PF14578.1 AIC16504.1 - 6.7 6.4 8.7 3.4 7.3 2.4 2.5 1 1 1 2 2 2 0 Elongation factor Tu domain 4 zf-FCS PF06467.9 AIC16505.1 - 0.034 13.7 0.9 0.052 13.1 0.6 1.5 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif NiFe_hyd_SSU_C PF14720.1 AIC16505.1 - 0.078 13.0 0.2 0.14 12.2 0.2 1.5 1 1 0 1 1 1 0 NiFe/NiFeSe hydrogenase small subunit C-terminal DUF581 PF04570.9 AIC16505.1 - 0.56 9.5 3.0 1.1 8.6 2.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF581) Beta-Casp PF10996.3 AIC16506.1 - 1.6e-18 66.8 0.0 5.1e-18 65.2 0.0 1.8 2 0 0 2 2 2 1 Beta-Casp domain Lactamase_B_2 PF12706.2 AIC16506.1 - 2.2e-12 46.9 0.0 4.5e-12 45.9 0.0 1.5 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 AIC16506.1 - 1e-10 41.6 0.0 1.3e-08 34.6 0.0 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily RMMBL PF07521.7 AIC16506.1 - 9.9e-07 28.4 0.2 3.8e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 RNA-metabolising metallo-beta-lactamase Lactamase_B_3 PF13483.1 AIC16506.1 - 6.8e-06 25.8 0.1 1.7e-05 24.6 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain CsgE PF10627.4 AIC16506.1 - 0.081 12.7 0.0 0.25 11.1 0.0 1.7 2 0 0 2 2 2 0 Curli assembly protein CsgE BNR_2 PF13088.1 AIC16507.1 - 1e-05 24.9 0.1 0.98 8.6 0.0 4.1 2 2 2 4 4 4 4 BNR repeat-like domain BNR PF02012.15 AIC16507.1 - 1.6e-05 23.9 12.3 2.8 8.1 0.1 6.7 6 0 0 6 6 6 3 BNR/Asp-box repeat Glyco_hydro_43 PF04616.9 AIC16507.1 - 0.054 12.5 0.1 15 4.5 0.0 3.3 2 2 1 3 3 3 0 Glycosyl hydrolases family 43 Methyltransf_23 PF13489.1 AIC16508.1 - 0.00062 19.5 0.0 0.0012 18.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC16508.1 - 0.023 14.3 0.0 0.04 13.5 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 AIC16508.1 - 0.084 12.2 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_18 PF12847.2 AIC16508.1 - 0.11 13.1 0.2 1.4 9.5 0.1 2.7 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.1 AIC16509.1 - 0.018 14.7 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Thy1 PF02511.10 AIC16509.1 - 0.096 12.0 0.3 2.9 7.2 0.0 2.1 2 0 0 2 2 2 0 Thymidylate synthase complementing protein Rad10 PF03834.9 AIC16511.1 - 0.11 12.1 0.0 0.89 9.2 0.0 2.1 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Endonuclease_5 PF04493.9 AIC16513.1 - 1.2e-48 165.1 0.0 1.6e-48 164.8 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V DUF99 PF01949.11 AIC16513.1 - 0.016 14.3 0.0 0.028 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF99 TGT PF01702.13 AIC16514.1 - 3.7e-45 154.0 0.0 5.4e-45 153.5 0.0 1.2 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Lsm_C PF14894.1 AIC16515.1 - 7.8e-21 73.3 1.1 1.5e-20 72.4 0.1 1.9 2 0 0 2 2 2 1 Lsm C-terminal SM-ATX PF14438.1 AIC16515.1 - 2e-05 24.4 0.1 3.3e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM PF01423.17 AIC16515.1 - 4e-05 23.0 0.2 6.9e-05 22.3 0.2 1.4 1 0 0 1 1 1 1 LSM domain LSM14 PF12701.2 AIC16515.1 - 0.0013 18.4 0.0 0.0035 17.1 0.0 1.7 1 1 0 1 1 1 1 Scd6-like Sm domain AHSA1 PF08327.6 AIC16516.1 - 0.0026 17.8 0.0 0.0028 17.7 0.0 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein AAA_18 PF13238.1 AIC16519.1 - 7.8e-12 45.6 0.2 1.1e-11 45.1 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC16519.1 - 7.7e-09 36.4 0.1 9.2e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA PF00004.24 AIC16519.1 - 9e-05 22.6 0.9 0.00013 22.1 0.6 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.10 AIC16519.1 - 0.00055 19.6 0.2 0.0046 16.6 0.0 2.2 1 1 2 3 3 3 1 NTPase AAA_22 PF13401.1 AIC16519.1 - 0.0022 18.1 0.2 0.0052 16.9 0.2 1.9 1 1 0 1 1 1 1 AAA domain SKI PF01202.17 AIC16519.1 - 0.0023 17.8 0.5 0.01 15.6 0.3 1.9 1 1 0 1 1 1 1 Shikimate kinase Cytidylate_kin2 PF13189.1 AIC16519.1 - 0.0031 17.4 0.2 1.2 8.9 0.1 2.8 1 1 1 2 2 2 2 Cytidylate kinase-like family RuvB_N PF05496.7 AIC16519.1 - 0.0076 15.3 0.0 0.014 14.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus AAA_19 PF13245.1 AIC16519.1 - 0.023 14.4 0.1 0.053 13.2 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain MobB PF03205.9 AIC16519.1 - 0.024 14.3 1.6 2.1 8.0 0.5 2.2 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B KTI12 PF08433.5 AIC16519.1 - 0.025 13.7 0.1 0.048 12.8 0.1 1.4 1 0 0 1 1 1 0 Chromatin associated protein KTI12 ArgK PF03308.11 AIC16519.1 - 0.025 13.3 0.5 0.072 11.8 0.1 1.8 1 1 0 2 2 2 0 ArgK protein APS_kinase PF01583.15 AIC16519.1 - 0.036 13.7 0.1 0.065 12.8 0.1 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase Topoisom_bac PF01131.15 AIC16519.1 - 0.037 12.8 0.3 0.055 12.2 0.2 1.3 1 0 0 1 1 1 0 DNA topoisomerase DAP3 PF10236.4 AIC16519.1 - 0.039 12.8 0.2 1 8.2 0.1 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_14 PF13173.1 AIC16519.1 - 0.043 13.7 0.1 0.33 10.8 0.0 2.2 1 1 0 1 1 1 0 AAA domain GATA PF00320.22 AIC16520.1 - 0.005 16.1 0.9 0.19 11.1 0.1 2.1 2 0 0 2 2 2 1 GATA zinc finger Spt4 PF06093.8 AIC16520.1 - 0.01 15.7 1.8 0.011 15.5 1.3 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger FYDLN_acid PF09538.5 AIC16520.1 - 0.1 13.1 0.5 0.11 13.0 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF35_N PF12172.3 AIC16520.1 - 0.18 11.7 1.8 0.31 10.9 0.0 1.9 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RRN7 PF11781.3 AIC16520.1 - 1.4 8.4 4.1 2.1 7.9 0.1 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 ADK_lid PF05191.9 AIC16520.1 - 1.9 8.2 4.4 7.9 6.2 3.1 1.9 1 1 0 1 1 1 0 Adenylate kinase, active site lid zinc_ribbon_2 PF13240.1 AIC16521.1 - 3.8e-07 29.3 3.6 6.4e-07 28.6 2.5 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC16521.1 - 1.2e-06 27.5 3.2 2.1e-06 26.7 2.2 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 AIC16521.1 - 3.4e-06 26.7 1.0 5.3e-06 26.1 0.7 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-DHHC PF01529.15 AIC16521.1 - 0.0041 16.5 0.0 0.0041 16.5 0.0 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase Nudix_N_2 PF14803.1 AIC16521.1 - 0.022 14.4 5.7 0.72 9.5 0.2 2.5 2 0 0 2 2 2 0 Nudix N-terminal UPF0547 PF10571.4 AIC16521.1 - 0.082 12.6 2.8 0.75 9.5 2.3 2.0 1 1 1 2 2 2 0 Uncharacterised protein family UPF0547 NOB1_Zn_bind PF08772.6 AIC16521.1 - 0.23 11.3 6.2 7.1 6.5 0.3 2.8 3 1 1 4 4 4 0 Nin one binding (NOB1) Zn-ribbon like zf-C4H2 PF10146.4 AIC16521.1 - 0.29 11.1 2.3 0.44 10.5 1.6 1.3 1 1 0 1 1 1 0 Zinc finger-containing protein zf-NADH-PPase PF09297.6 AIC16521.1 - 0.41 10.1 4.4 15 5.1 3.1 2.3 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain RNA_POL_M_15KD PF02150.11 AIC16521.1 - 0.92 9.2 4.6 9.1 6.0 0.1 2.9 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit YhfH PF14149.1 AIC16521.1 - 1.1 9.0 6.0 4.6 7.1 0.2 2.3 1 1 1 2 2 2 0 YhfH-like protein zinc_ribbon_2 PF13240.1 AIC16522.1 - 5.5e-06 25.6 4.0 8.3e-06 25.1 2.8 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC16522.1 - 1.3e-05 24.2 3.6 2e-05 23.6 2.5 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 AIC16522.1 - 0.00024 20.8 1.0 0.00036 20.2 0.7 1.3 1 0 0 1 1 1 1 Double zinc ribbon DUF2116 PF09889.4 AIC16522.1 - 0.0025 17.5 2.3 0.0052 16.5 1.6 1.5 1 0 0 1 1 1 1 Uncharacterized protein containing a Zn-ribbon (DUF2116) UPF0547 PF10571.4 AIC16522.1 - 0.12 12.0 4.1 0.22 11.2 2.8 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 YhfH PF14149.1 AIC16522.1 - 0.52 10.1 3.9 8.8 6.2 0.0 2.3 1 1 1 2 2 2 0 YhfH-like protein DEAD PF00270.24 AIC16523.1 - 2.6e-51 173.4 0.3 3.5e-49 166.5 0.0 2.5 2 1 1 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AIC16523.1 - 2.2e-27 94.7 0.4 1.9e-26 91.7 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 AIC16523.1 - 8.5e-05 21.4 0.0 0.00014 20.7 0.0 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.10 AIC16523.1 - 0.00025 20.9 0.0 0.00052 19.8 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.9 AIC16523.1 - 0.00038 20.1 0.1 0.0017 18.0 0.0 2.0 1 1 1 2 2 2 1 Helicase DUF1253 PF06862.7 AIC16523.1 - 0.00059 18.3 0.0 0.035 12.5 0.0 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF1253) Flavi_DEAD PF07652.9 AIC16523.1 - 0.0015 18.3 0.2 0.21 11.3 0.1 2.7 2 1 0 2 2 2 1 Flavivirus DEAD domain CMS1 PF14617.1 AIC16523.1 - 0.0046 16.0 0.6 0.011 14.7 0.2 1.7 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_30 PF13604.1 AIC16523.1 - 0.0066 16.0 0.3 0.12 11.9 0.0 2.4 2 1 0 2 2 2 1 AAA domain LuxC PF05893.9 AIC16523.1 - 0.038 12.7 0.2 0.37 9.4 0.0 2.0 2 0 0 2 2 2 0 Acyl-CoA reductase (LuxC) PspA_IM30 PF04012.7 AIC16524.1 - 0.0011 18.3 4.5 0.0015 17.9 3.1 1.2 1 0 0 1 1 1 1 PspA/IM30 family ArsA_ATPase PF02374.10 AIC16524.1 - 0.003 16.6 1.3 0.0038 16.3 0.9 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase Myosin_tail_1 PF01576.14 AIC16524.1 - 0.0095 13.7 9.7 0.012 13.4 6.8 1.1 1 0 0 1 1 1 1 Myosin tail Spc7 PF08317.6 AIC16524.1 - 0.012 14.2 5.1 0.017 13.7 3.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1840 PF08895.6 AIC16524.1 - 0.029 14.3 2.7 0.047 13.7 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1840) Tropomyosin PF00261.15 AIC16524.1 - 0.032 13.3 8.3 0.048 12.7 5.8 1.3 1 0 0 1 1 1 0 Tropomyosin V_ATPase_I PF01496.14 AIC16524.1 - 0.039 11.8 1.5 0.045 11.6 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Flagellin_C PF00700.16 AIC16524.1 - 0.054 13.6 1.7 0.11 12.6 1.2 1.5 1 0 0 1 1 1 0 Bacterial flagellin C-terminal helical region DUF972 PF06156.8 AIC16524.1 - 0.069 13.4 4.1 0.11 12.9 2.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF972) DUF16 PF01519.11 AIC16524.1 - 0.075 13.2 3.9 0.11 12.7 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF342 PF03961.8 AIC16524.1 - 0.081 11.3 0.8 0.096 11.0 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF342) Reo_sigmaC PF04582.7 AIC16524.1 - 0.085 12.0 1.3 0.12 11.5 0.7 1.3 1 1 0 1 1 1 0 Reovirus sigma C capsid protein MscS_porin PF12795.2 AIC16524.1 - 0.095 12.0 8.7 0.086 12.1 5.4 1.3 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF2390 PF09523.5 AIC16524.1 - 0.099 12.8 3.6 0.18 11.9 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2390) Macoilin PF09726.4 AIC16524.1 - 0.11 10.7 8.9 0.14 10.3 6.2 1.0 1 0 0 1 1 1 0 Transmembrane protein DUF1664 PF07889.7 AIC16524.1 - 0.11 12.2 5.9 0.19 11.5 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) IncA PF04156.9 AIC16524.1 - 0.16 11.5 10.2 0.34 10.4 7.1 1.7 1 1 0 1 1 1 0 IncA protein Lebercilin PF15619.1 AIC16524.1 - 0.44 9.9 13.9 0.38 10.1 7.9 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease APG6 PF04111.7 AIC16524.1 - 0.46 9.4 6.1 0.6 9.1 4.3 1.1 1 0 0 1 1 1 0 Autophagy protein Apg6 SKIP_SNW PF02731.10 AIC16524.1 - 0.49 9.8 6.0 0.7 9.3 4.2 1.3 1 0 0 1 1 1 0 SKIP/SNW domain GvpL_GvpF PF06386.6 AIC16524.1 - 0.6 9.6 4.1 0.79 9.2 2.8 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF FliD_N PF02465.13 AIC16524.1 - 0.68 10.3 7.5 0.89 9.9 3.6 2.2 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Toxin_52 PF15605.1 AIC16524.1 - 0.74 9.7 4.8 2.6 7.9 1.8 2.3 1 1 1 2 2 2 0 Putative toxin 52 TPR_MLP1_2 PF07926.7 AIC16524.1 - 1.1 8.9 11.7 0.63 9.7 6.2 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.4 AIC16524.1 - 1.5 7.6 8.7 1.8 7.4 6.0 1.1 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Phage_Gp23 PF10669.4 AIC16524.1 - 2.3 8.3 11.2 19 5.3 5.7 2.1 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) COG2 PF06148.6 AIC16524.1 - 2.3 8.0 6.9 6.9 6.5 4.7 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Lipoprotein_20 PF13942.1 AIC16524.1 - 4.2 6.8 9.8 7.2 6.1 4.4 2.1 1 1 1 2 2 2 0 YfhG lipoprotein DUF4446 PF14584.1 AIC16524.1 - 5.4 6.8 7.0 12 5.7 3.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF3847 PF12958.2 AIC16524.1 - 7.3 6.4 11.2 4.5 7.1 3.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3847) bZIP_2 PF07716.10 AIC16525.1 - 0.026 14.3 0.8 0.39 10.5 0.1 2.1 2 0 0 2 2 2 0 Basic region leucine zipper CARD PF00619.16 AIC16525.1 - 0.038 13.8 0.4 0.041 13.7 0.3 1.2 1 0 0 1 1 1 0 Caspase recruitment domain Spc24 PF08286.6 AIC16525.1 - 0.06 13.0 1.0 0.063 12.9 0.7 1.0 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 FeoC PF09012.5 AIC16525.1 - 0.12 12.1 0.1 0.13 12.0 0.1 1.1 1 0 0 1 1 1 0 FeoC like transcriptional regulator Prefoldin_2 PF01920.15 AIC16525.1 - 0.14 11.9 0.7 0.18 11.5 0.3 1.4 1 1 0 1 1 1 0 Prefoldin subunit TMF_DNA_bd PF12329.3 AIC16525.1 - 0.14 11.9 0.3 0.14 11.9 0.2 1.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding HALZ PF02183.13 AIC16525.1 - 0.14 11.8 0.9 0.22 11.2 0.6 1.3 1 0 0 1 1 1 0 Homeobox associated leucine zipper SlyX PF04102.7 AIC16525.1 - 0.18 12.2 0.5 0.19 12.1 0.3 1.2 1 0 0 1 1 1 0 SlyX DMPK_coil PF08826.5 AIC16525.1 - 0.21 11.4 1.4 0.29 11.0 0.3 1.6 2 0 0 2 2 2 0 DMPK coiled coil domain like M PF02370.11 AIC16525.1 - 0.44 11.0 0.0 0.44 11.0 0.0 2.2 3 0 0 3 3 3 0 M protein repeat RHH_1 PF01402.16 AIC16526.1 - 4e-05 23.3 0.0 6.2e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family DDE_Tnp_IS240 PF13610.1 AIC16527.1 - 1.2e-25 90.0 0.7 2e-25 89.3 0.5 1.4 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16527.1 - 1.1e-09 38.4 0.2 2.9e-09 37.0 0.1 1.7 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC16527.1 - 7e-08 32.0 0.1 1.3e-07 31.0 0.1 1.6 1 1 0 1 1 1 1 Transposase IS66 family rve_3 PF13683.1 AIC16527.1 - 2.3e-07 30.2 0.0 6.2e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain Transposase_mut PF00872.13 AIC16527.1 - 1.2e-05 24.0 0.2 0.00064 18.3 0.0 2.2 2 0 0 2 2 2 1 Transposase, Mutator family DNA_RNApol_7kD PF03604.8 AIC16527.1 - 0.018 14.5 2.6 2.6 7.6 0.0 2.6 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Tmemb_9 PF05434.6 AIC16527.1 - 0.028 14.1 2.2 0.041 13.6 0.4 1.9 2 0 0 2 2 2 0 TMEM9 Zn_Tnp_IS1 PF03811.8 AIC16527.1 - 0.065 12.7 6.4 0.14 11.6 4.5 1.6 1 0 0 1 1 1 0 InsA N-terminal domain HTH_28 PF13518.1 AIC16527.1 - 0.12 12.3 0.3 0.92 9.5 0.1 2.6 2 1 0 2 2 2 0 Helix-turn-helix domain zinc_ribbon_4 PF13717.1 AIC16527.1 - 0.22 11.2 2.8 0.66 9.7 1.9 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC16527.1 - 0.52 9.9 3.5 1.8 8.2 2.4 1.9 1 1 0 1 1 1 0 zinc-ribbon domain TerC PF03741.11 AIC16529.1 - 0.006 16.0 1.5 0.14 11.6 0.2 2.5 2 1 1 3 3 3 1 Integral membrane protein TerC family DUF2684 PF10885.3 AIC16529.1 - 0.07 13.0 0.3 0.07 13.0 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) DUF2339 PF10101.4 AIC16529.1 - 0.24 9.6 2.2 0.099 10.9 0.1 1.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2339) Bax1-I PF01027.15 AIC16529.1 - 0.96 9.0 13.3 4.1 6.9 5.0 3.0 1 1 2 3 3 3 0 Inhibitor of apoptosis-promoting Bax1 Na_Ca_ex PF01699.19 AIC16529.1 - 6.7 6.3 9.2 0.79 9.3 0.5 2.7 3 1 1 4 4 4 0 Sodium/calcium exchanger protein KaiA PF07688.7 AIC16530.1 - 0.085 12.1 0.0 0.086 12.1 0.0 1.0 1 0 0 1 1 1 0 KaiA domain CYTH PF01928.16 AIC16530.1 - 0.1 12.2 0.0 0.1 12.2 0.0 1.0 1 0 0 1 1 1 0 CYTH domain NAD_binding_1 PF00175.16 AIC16531.1 - 0.043 14.3 0.0 0.05 14.1 0.0 1.1 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain KaiC PF06745.8 AIC16533.1 - 3.7e-19 68.7 0.0 6.5e-19 67.9 0.0 1.3 1 0 0 1 1 1 1 KaiC Guanylate_cyc PF00211.15 AIC16533.1 - 9.2e-05 21.8 0.0 0.0002 20.7 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AAA_25 PF13481.1 AIC16533.1 - 9.3e-05 21.9 0.2 0.00046 19.6 0.0 2.3 3 1 0 3 3 3 1 AAA domain AAA_19 PF13245.1 AIC16533.1 - 0.00068 19.3 1.2 0.0034 17.0 0.0 2.8 2 2 0 2 2 2 1 Part of AAA domain AAA_22 PF13401.1 AIC16533.1 - 0.0015 18.6 0.0 0.0031 17.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.1 AIC16533.1 - 0.0052 16.6 0.0 0.014 15.2 0.0 1.7 2 0 0 2 2 2 1 AAA domain GvpD PF07088.6 AIC16533.1 - 0.0061 14.9 0.1 0.038 12.3 0.0 1.9 1 1 0 1 1 1 1 GvpD gas vesicle protein IstB_IS21 PF01695.12 AIC16533.1 - 0.0068 15.8 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein ATP_bind_1 PF03029.12 AIC16533.1 - 0.0076 15.8 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_10 PF12846.2 AIC16533.1 - 0.027 13.8 0.0 0.14 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA-like domain Zot PF05707.7 AIC16533.1 - 0.031 13.7 0.0 0.048 13.1 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_16 PF13191.1 AIC16533.1 - 0.035 14.1 0.5 0.15 11.9 0.3 2.1 1 1 0 1 1 1 0 AAA ATPase domain LIM PF00412.17 AIC16533.1 - 0.071 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 LIM domain AAA PF00004.24 AIC16533.1 - 0.072 13.2 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.18 AIC16534.1 - 8.1e-24 84.1 0.0 1.2e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 AIC16534.1 - 1.2e-13 51.3 0.0 7.8e-11 42.1 0.0 2.7 3 0 0 3 3 3 2 AAA domain MipZ PF09140.6 AIC16534.1 - 1.4e-08 34.1 0.0 1.2e-06 27.7 0.0 2.1 1 1 1 2 2 2 2 ATPase MipZ ArsA_ATPase PF02374.10 AIC16534.1 - 9e-05 21.6 0.1 0.00016 20.8 0.1 1.6 1 1 0 1 1 1 1 Anion-transporting ATPase VirC1 PF07015.6 AIC16534.1 - 0.00012 21.1 0.6 0.00027 20.0 0.1 1.7 2 0 0 2 2 2 1 VirC1 protein SRP54 PF00448.17 AIC16534.1 - 0.0022 17.4 0.2 0.0059 16.0 0.1 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain Fer4_NifH PF00142.13 AIC16534.1 - 0.0087 15.2 0.0 0.026 13.7 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family APS_kinase PF01583.15 AIC16534.1 - 0.044 13.4 0.0 0.088 12.4 0.0 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_19 PF13245.1 AIC16534.1 - 0.092 12.5 0.3 0.28 10.9 0.2 1.7 1 0 0 1 1 1 0 Part of AAA domain MobB PF03205.9 AIC16534.1 - 0.098 12.3 0.0 0.24 11.0 0.0 1.6 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B LpxK PF02606.9 AIC16534.1 - 0.11 11.4 0.1 0.17 10.8 0.1 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase AAA_17 PF13207.1 AIC16534.1 - 0.14 12.9 0.2 0.3 11.9 0.1 1.6 1 1 0 1 1 1 0 AAA domain HTH_5 PF01022.15 AIC16535.1 - 7.8e-08 31.8 0.0 1.1e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.2 AIC16535.1 - 4.9e-05 23.0 0.0 9.2e-05 22.1 0.0 1.5 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.14 AIC16535.1 - 6.7e-05 22.5 0.0 9.8e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC16535.1 - 0.0043 16.3 0.1 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding FaeA PF04703.7 AIC16535.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 FaeA-like protein MarR PF01047.17 AIC16535.1 - 0.025 14.3 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_34 PF13601.1 AIC16535.1 - 0.053 13.5 0.0 0.083 12.9 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain B-block_TFIIIC PF04182.7 AIC16535.1 - 0.056 13.2 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC MarR_2 PF12802.2 AIC16535.1 - 0.082 12.5 0.0 0.14 11.8 0.0 1.5 1 1 0 1 1 1 0 MarR family HTH_11 PF08279.7 AIC16535.1 - 0.093 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 HTH domain HTH_45 PF14947.1 AIC16535.1 - 0.096 12.5 0.1 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DUF423 PF04241.10 AIC16536.1 - 0.23 11.4 4.4 0.2 11.5 2.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF423) CitMHS PF03600.11 AIC16536.1 - 0.44 9.0 7.9 0.49 8.9 5.5 1.0 1 0 0 1 1 1 0 Citrate transporter DUF2614 PF11023.3 AIC16536.1 - 0.92 9.3 5.1 0.9 9.3 3.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2614) DUF4131 PF13567.1 AIC16536.1 - 0.97 8.8 3.4 1 8.7 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) TRIQK PF15168.1 AIC16536.1 - 1 9.3 5.1 0.47 10.4 0.2 2.1 1 1 1 2 2 2 0 Triple QxxK/R motif-containing protein family DsbD PF02683.10 AIC16537.1 - 5e-46 156.9 18.0 5.1e-36 124.2 10.5 2.0 2 0 0 2 2 2 2 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.1 AIC16537.1 - 2.4e-07 30.7 19.8 4.4e-07 29.8 13.7 1.4 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DUF872 PF05915.7 AIC16537.1 - 2.5 8.0 6.0 20 5.0 0.6 2.5 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) AhpC-TSA PF00578.16 AIC16538.1 - 2.6e-16 59.4 0.0 5.8e-16 58.2 0.0 1.5 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.5 AIC16538.1 - 5.1e-16 58.5 0.0 8.2e-16 57.8 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.1 AIC16538.1 - 1.3e-09 38.0 0.2 2.3e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like GSHPx PF00255.14 AIC16538.1 - 0.00043 19.6 0.0 0.00085 18.6 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin_2 PF13098.1 AIC16538.1 - 0.0078 16.4 0.0 0.016 15.3 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.15 AIC16538.1 - 0.037 13.7 0.0 0.069 12.8 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin SCO1-SenC PF02630.9 AIC16538.1 - 0.046 13.3 0.1 0.31 10.6 0.0 2.0 1 1 1 2 2 2 0 SCO1/SenC DZR PF12773.2 AIC16539.1 - 0.00066 19.4 6.1 0.0025 17.5 4.4 1.8 1 1 1 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.1 AIC16539.1 - 0.02 14.3 6.5 2.9 7.5 0.1 3.3 3 0 0 3 3 3 0 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC16539.1 - 0.026 13.7 8.0 0.14 11.3 0.6 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Ribosomal_S27 PF01599.14 AIC16539.1 - 0.097 12.5 0.4 0.097 12.5 0.3 2.1 2 0 0 2 2 2 0 Ribosomal protein S27a NMD3 PF04981.8 AIC16539.1 - 0.12 11.4 3.0 0.58 9.2 0.4 2.0 1 1 1 2 2 2 0 NMD3 family NCD3G PF07562.9 AIC16539.1 - 0.44 10.3 4.7 0.92 9.2 0.2 2.2 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR Ribosomal_L37e PF01907.14 AIC16539.1 - 0.46 10.3 7.6 0.86 9.4 1.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e zf-NADH-PPase PF09297.6 AIC16539.1 - 0.51 9.8 4.6 3.5 7.2 0.7 2.8 2 1 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain XPA_N PF01286.13 AIC16539.1 - 0.72 9.5 10.5 1.8 8.2 1.5 3.9 3 1 1 4 4 4 0 XPA protein N-terminal DnaJ_CXXCXGXG PF00684.14 AIC16539.1 - 1.9 8.6 11.0 43 4.2 7.6 2.3 1 1 0 1 1 1 0 DnaJ central domain Lar_restr_allev PF14354.1 AIC16539.1 - 4.3 7.7 6.4 5 7.5 0.0 2.4 1 1 1 2 2 2 0 Restriction alleviation protein Lar zf-RING_3 PF14369.1 AIC16539.1 - 5.1 7.1 0.0 5.1 7.1 0.0 3.2 3 1 0 3 3 3 0 zinc-finger PyrI PF01948.13 AIC16540.1 - 2.9e-36 123.3 2.0 2.9e-36 123.3 1.4 1.4 2 0 0 2 2 2 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain PyrI_C PF02748.10 AIC16540.1 - 1.2e-16 59.9 1.0 2e-16 59.1 0.7 1.3 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain A2M_N PF01835.14 AIC16542.1 - 7.5e-07 29.3 0.0 3e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 MG2 domain He_PIG PF05345.7 AIC16542.1 - 0.11 12.5 0.1 1.7 8.6 0.0 3.0 3 1 0 3 3 3 0 Putative Ig domain Lactamase_B_2 PF12706.2 AIC16544.1 - 3.6e-06 26.6 0.0 6.9e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.1 AIC16544.1 - 0.00023 20.9 0.0 0.0007 19.3 0.0 1.8 1 1 1 2 2 2 1 Beta-lactamase superfamily domain DUF3483 PF11982.3 AIC16545.1 - 0.049 12.9 0.8 0.052 12.8 0.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3483) DUF4181 PF13789.1 AIC16545.1 - 0.056 13.3 0.3 0.061 13.2 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) DUF4131 PF13567.1 AIC16545.1 - 0.067 12.5 1.3 0.074 12.4 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF2798 PF11391.3 AIC16545.1 - 0.34 10.6 5.7 6.3 6.6 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2798) IncA PF04156.9 AIC16545.1 - 0.35 10.4 3.7 0.42 10.1 2.5 1.0 1 0 0 1 1 1 0 IncA protein Halogen_Hydrol PF10112.4 AIC16545.1 - 0.97 8.8 2.7 1.1 8.6 1.9 1.0 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein FbpA PF05833.6 AIC16546.1 - 1.9e-36 125.6 0.8 2.8e-36 125.0 0.6 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) DUF814 PF05670.8 AIC16546.1 - 5.2e-19 67.9 0.1 1.5e-18 66.4 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF814) CBS PF00571.23 AIC16547.1 - 2.7e-28 97.4 2.5 1.2e-13 50.5 0.2 2.5 2 0 0 2 2 2 2 CBS domain TF_Zn_Ribbon PF08271.7 AIC16547.1 - 0.026 13.8 3.0 0.044 13.1 1.4 1.9 2 0 0 2 2 2 0 TFIIB zinc-binding zf-dskA_traR PF01258.12 AIC16547.1 - 2.1 8.1 5.0 2.3 8.0 0.9 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Mut7-C PF01927.11 AIC16548.1 - 8.3e-41 139.3 0.0 9.7e-41 139.1 0.0 1.0 1 0 0 1 1 1 1 Mut7-C RNAse domain DUF188 PF02639.9 AIC16548.1 - 0.071 12.5 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 vATP-synt_E PF01991.13 AIC16549.1 - 1.5e-24 86.4 9.1 3.2e-24 85.3 5.6 1.7 1 1 1 2 2 2 1 ATP synthase (E/31 kDa) subunit Phage_antitermQ PF06530.7 AIC16549.1 - 0.0017 17.8 0.3 0.0048 16.4 0.1 1.7 2 0 0 2 2 2 1 Phage antitermination protein Q DWNN PF08783.6 AIC16549.1 - 0.091 12.7 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 DWNN domain ATP-synt_E_2 PF08112.6 AIC16549.1 - 0.099 12.7 1.4 1.5 8.9 0.3 2.9 2 1 1 3 3 3 0 ATP synthase epsilon subunit Sin3_corepress PF08295.7 AIC16549.1 - 0.11 12.2 0.7 14 5.5 0.2 2.5 2 0 0 2 2 2 0 Sin3 family co-repressor GLTSCR1 PF15249.1 AIC16549.1 - 0.24 11.5 1.9 0.56 10.3 1.3 1.7 1 0 0 1 1 1 0 Glioma tumor suppressor candidate region DUF4407 PF14362.1 AIC16549.1 - 0.39 9.6 4.8 0.4 9.5 2.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Nnf1 PF03980.9 AIC16549.1 - 5 7.1 8.5 65 3.5 5.9 2.5 1 1 0 1 1 1 0 Nnf1 Phage_Mu_Gam PF07352.7 AIC16549.1 - 6.5 6.2 12.9 9.9 5.6 0.5 3.7 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein ATP-synt_ab PF00006.20 AIC16550.1 - 3.7e-95 317.5 0.0 4.8e-95 317.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 AIC16550.1 - 2.6e-17 63.3 2.4 6.3e-17 62.0 1.7 1.7 1 1 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 AIC16550.1 - 1.6e-13 50.6 0.7 4.6e-13 49.1 0.2 2.1 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_19 PF13245.1 AIC16550.1 - 0.0063 16.2 0.0 0.06 13.1 0.0 2.5 1 1 0 1 1 1 1 Part of AAA domain DUF1409 PF07197.7 AIC16550.1 - 0.017 15.1 0.1 0.047 13.7 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) AAA_22 PF13401.1 AIC16550.1 - 0.036 14.2 0.0 0.083 13.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 AIC16551.1 - 1.6e-62 210.8 0.0 2.4e-62 210.2 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_C PF00306.22 AIC16551.1 - 4.8e-12 46.3 0.0 8.9e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain ATP-synt_ab_N PF02874.18 AIC16551.1 - 7e-09 35.7 1.1 1.7e-08 34.5 0.8 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.5 AIC16551.1 - 0.00016 21.5 0.9 0.00082 19.2 0.5 2.2 2 0 0 2 2 2 1 HAS barrel domain ATP-synt_D PF01813.12 AIC16552.1 - 5.6e-50 169.6 6.9 7.2e-50 169.2 4.8 1.0 1 0 0 1 1 1 1 ATP synthase subunit D Skp1_POZ PF03931.10 AIC16552.1 - 0.082 13.0 0.3 4.6 7.4 0.0 2.6 2 1 1 3 3 3 0 Skp1 family, tetramerisation domain Apolipoprotein PF01442.13 AIC16553.1 - 0.05 13.1 0.5 0.05 13.1 0.3 1.0 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain ATP-synt_B PF00430.13 AIC16553.1 - 0.052 13.3 2.9 0.051 13.3 2.0 1.0 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Atg14 PF10186.4 AIC16553.1 - 0.1 11.5 0.7 0.093 11.6 0.5 1.0 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 Snf7 PF03357.16 AIC16553.1 - 0.14 11.5 3.1 0.15 11.4 2.1 1.0 1 0 0 1 1 1 0 Snf7 ATP-synt_C PF00137.16 AIC16554.1 - 2.6e-18 65.6 18.1 2.6e-18 65.6 12.6 1.9 2 0 0 2 2 2 1 ATP synthase subunit C PMT PF02366.13 AIC16554.1 - 0.041 13.2 1.0 0.056 12.8 0.7 1.3 1 1 0 1 1 1 0 Dolichyl-phosphate-mannose-protein mannosyltransferase TrbC PF04956.8 AIC16554.1 - 2.8 8.0 14.8 0.27 11.2 6.2 2.1 1 1 1 2 2 2 0 TrbC/VIRB2 family DUF3693 PF12472.3 AIC16554.1 - 3.9 7.1 5.1 1.6 8.4 0.4 2.2 2 0 0 2 2 2 0 Phage related protein Tetraspannin PF00335.15 AIC16554.1 - 6.6 5.9 8.9 8.1 5.6 6.2 1.1 1 0 0 1 1 1 0 Tetraspanin family V_ATPase_I PF01496.14 AIC16555.1 - 1.2e-40 139.1 5.5 4.5e-40 137.2 3.8 1.9 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family PilN PF05137.8 AIC16555.1 - 0.0021 17.8 0.0 0.0051 16.6 0.0 1.6 1 0 0 1 1 1 1 Fimbrial assembly protein (PilN) DUF1192 PF06698.6 AIC16555.1 - 0.023 14.4 0.7 0.023 14.4 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Zn_ribbon_2 PF12674.2 AIC16556.1 - 6.9e-18 64.7 0.0 7.5e-18 64.6 0.0 1.0 1 0 0 1 1 1 1 Putative zinc ribbon domain vATP-synt_AC39 PF01992.11 AIC16557.1 - 4.7e-38 131.1 8.3 5.8e-38 130.8 5.8 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit PP1_inhibitor PF05361.7 AIC16557.1 - 0.0038 16.9 0.0 0.0084 15.8 0.0 1.6 1 0 0 1 1 1 1 PKC-activated protein phosphatase-1 inhibitor DUF3385 PF11865.3 AIC16558.1 - 0.067 13.1 0.1 0.094 12.6 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) UPF0104 PF03706.8 AIC16560.1 - 0.049 12.9 0.0 0.061 12.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0104) DUF475 PF04332.10 AIC16561.1 - 0.012 15.2 0.8 0.013 15.1 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF475) FUSC_2 PF13515.1 AIC16561.1 - 0.026 14.4 5.1 0.033 14.1 3.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein-like IncA PF04156.9 AIC16561.1 - 0.027 14.0 0.8 0.04 13.5 0.5 1.2 1 0 0 1 1 1 0 IncA protein Phage_holin_4 PF05105.7 AIC16561.1 - 0.15 11.7 2.0 0.12 12.0 0.5 1.4 1 1 0 1 1 1 0 Holin family DUF1761 PF08570.5 AIC16561.1 - 0.28 11.2 3.7 0.64 10.0 2.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1761) Peptidase_U4 PF03419.8 AIC16561.1 - 0.44 9.5 4.0 0.49 9.4 2.8 1.1 1 0 0 1 1 1 0 Sporulation factor SpoIIGA FUSC PF04632.7 AIC16561.1 - 0.56 8.5 2.4 0.78 8.1 1.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family RseC_MucC PF04246.7 AIC16561.1 - 0.66 9.5 3.3 0.23 11.0 0.2 1.7 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC NfeD PF01957.13 AIC16561.1 - 0.71 10.0 4.4 0.34 11.0 1.7 1.4 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding Bacteriocin_IIc PF10439.4 AIC16561.1 - 1.2 9.3 4.4 1.8 8.7 3.1 1.3 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Halogen_Hydrol PF10112.4 AIC16561.1 - 1.3 8.3 3.4 2 7.7 2.3 1.4 1 1 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein YesK PF14150.1 AIC16561.1 - 3.6 7.7 10.0 13 5.9 1.4 3.0 3 0 0 3 3 3 0 YesK-like protein Rab5ip PF07019.7 AIC16561.1 - 4.4 7.4 11.9 10 6.3 3.9 2.7 1 1 1 2 2 2 0 Rab5-interacting protein (Rab5ip) Gly-zipper_YMGG PF13441.1 AIC16561.1 - 4.5 6.8 9.3 6.5 6.3 6.4 1.3 1 0 0 1 1 1 0 YMGG-like Gly-zipper FeoB_C PF07664.7 AIC16561.1 - 8.4 5.9 6.1 6.7 6.2 0.1 2.5 3 0 0 3 3 3 0 Ferrous iron transport protein B C terminus Methyltransf_18 PF12847.2 AIC16562.1 - 1.7e-15 57.5 0.1 2.6e-15 56.9 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC16562.1 - 1e-14 54.3 0.1 2.2e-14 53.3 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC16562.1 - 4.8e-10 39.7 0.1 9.9e-10 38.7 0.0 1.5 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.9 AIC16562.1 - 6.3e-10 38.6 0.2 4.4e-09 35.9 0.2 2.1 1 1 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.8 AIC16562.1 - 6.9e-10 38.5 1.4 8.8e-10 38.1 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_26 PF13659.1 AIC16562.1 - 2.6e-09 37.1 0.1 6.7e-09 35.7 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 AIC16562.1 - 1.4e-08 34.5 0.2 1.7e-08 34.2 0.1 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_11 PF08241.7 AIC16562.1 - 4.7e-08 33.4 0.1 1e-07 32.3 0.0 1.6 2 0 0 2 2 1 1 Methyltransferase domain CMAS PF02353.15 AIC16562.1 - 2.7e-07 29.9 0.1 3.6e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase GCD14 PF08704.5 AIC16562.1 - 3.8e-07 29.8 0.0 5.4e-07 29.3 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_12 PF08242.7 AIC16562.1 - 1e-06 29.1 0.1 2.1e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 AIC16562.1 - 2.4e-06 27.2 0.1 4.6e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.1 AIC16562.1 - 3.7e-06 26.7 0.0 6.3e-06 26.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.1 AIC16562.1 - 4.3e-06 27.5 0.0 6.9e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC16562.1 - 1.1e-05 24.6 0.2 1.5e-05 24.2 0.2 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.10 AIC16562.1 - 0.00015 21.1 0.0 0.00018 20.9 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_3 PF01596.12 AIC16562.1 - 0.00019 20.5 0.2 0.00044 19.3 0.1 1.5 1 1 0 1 1 1 1 O-methyltransferase RrnaAD PF00398.15 AIC16562.1 - 0.00049 19.2 0.0 0.00065 18.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Met_10 PF02475.11 AIC16562.1 - 0.00085 18.9 0.0 0.0012 18.4 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_32 PF13679.1 AIC16562.1 - 0.0022 17.7 0.0 0.0029 17.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.14 AIC16562.1 - 0.0045 16.3 0.1 0.031 13.5 0.0 1.9 1 1 1 2 2 2 1 MraW methylase family Methyltransf_15 PF09445.5 AIC16562.1 - 0.0052 16.3 0.0 0.0072 15.8 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase FmrO PF07091.6 AIC16562.1 - 0.0077 15.2 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA methyltransferase (FmrO) Methyltransf_4 PF02390.12 AIC16562.1 - 0.0084 15.1 0.1 0.073 12.1 0.0 2.0 2 0 0 2 2 2 1 Putative methyltransferase POR PF01558.13 AIC16562.1 - 0.014 15.3 0.1 0.046 13.6 0.0 1.7 1 1 1 2 2 2 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Spermine_synth PF01564.12 AIC16562.1 - 0.034 13.0 0.1 0.039 12.8 0.1 1.3 1 0 0 1 1 1 0 Spermine/spermidine synthase NodS PF05401.6 AIC16562.1 - 0.04 13.3 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 Nodulation protein S (NodS) AviRa PF11599.3 AIC16562.1 - 0.048 12.6 0.0 0.073 12.0 0.0 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa FtsJ PF01728.14 AIC16562.1 - 0.071 13.0 0.1 0.34 10.8 0.1 1.9 1 1 0 1 1 1 0 FtsJ-like methyltransferase DOT1 PF08123.8 AIC16562.1 - 0.074 12.3 0.2 0.21 10.8 0.0 1.7 2 0 0 2 2 2 0 Histone methylation protein DOT1 Methyltransf_PK PF05891.7 AIC16562.1 - 0.085 12.1 0.1 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase N6_N4_Mtase PF01555.13 AIC16563.1 - 2e-42 145.2 0.0 2.5e-42 144.9 0.0 1.0 1 0 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 AIC16563.1 - 1.2e-08 34.9 0.1 0.0028 17.6 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain UPF0020 PF01170.13 AIC16563.1 - 0.012 15.2 0.0 0.46 10.0 0.0 2.2 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 Myc_target_1 PF15179.1 AIC16564.1 - 0.33 10.5 1.5 0.37 10.3 1.1 1.1 1 0 0 1 1 1 0 Myc target protein 1 OppC_N PF12911.2 AIC16564.1 - 6 6.3 8.0 7 6.1 4.7 1.7 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Holin_BlyA PF05102.7 AIC16564.1 - 6.7 6.5 7.8 14 5.4 5.4 1.6 1 1 0 1 1 1 0 holin, BlyA family Cation_efflux PF01545.16 AIC16565.1 - 6.8e-72 241.9 5.9 7.6e-72 241.7 4.1 1.0 1 0 0 1 1 1 1 Cation efflux family DUF11 PF01345.13 AIC16567.1 - 0.034 14.1 0.1 0.062 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF11 zf-C2H2_4 PF13894.1 AIC16570.1 - 0.0058 16.8 1.2 0.0093 16.2 0.8 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger DUF3508 PF12018.3 AIC16570.1 - 0.023 13.7 0.0 0.024 13.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3508) Pox_P35 PF03213.9 AIC16570.1 - 0.069 12.1 0.0 0.079 11.9 0.0 1.0 1 0 0 1 1 1 0 Poxvirus P35 protein VTC PF09359.5 AIC16570.1 - 0.086 11.8 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 VTC domain DUF4537 PF15057.1 AIC16570.1 - 0.13 11.9 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) Kinesin-relat_1 PF12711.2 AIC16570.1 - 0.15 12.4 0.2 0.24 11.8 0.1 1.3 1 0 0 1 1 1 0 Kinesin motor Pyridox_oxidase PF01243.15 AIC16571.1 - 7.6e-06 25.8 0.0 1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase DUF385 PF04075.9 AIC16571.1 - 0.00062 19.7 0.0 0.00088 19.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF385) Pyridox_ox_2 PF12900.2 AIC16571.1 - 0.0067 16.2 0.0 0.009 15.8 0.0 1.4 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase InvH PF04741.7 AIC16573.1 - 0.061 13.1 2.9 0.13 12.0 2.0 1.5 1 0 0 1 1 1 0 InvH outer membrane lipoprotein LMP PF04778.7 AIC16573.1 - 0.073 12.8 4.5 0.03 14.0 1.0 1.8 2 0 0 2 2 2 0 LMP repeated region Laminin_II PF06009.7 AIC16573.1 - 0.08 12.6 6.3 0.21 11.3 1.5 2.2 2 0 0 2 2 2 0 Laminin Domain II Apolipoprotein PF01442.13 AIC16573.1 - 0.15 11.5 9.5 0.57 9.6 6.6 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.8 AIC16573.1 - 0.17 12.3 13.7 0.84 10.0 1.0 3.4 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF1543 PF07566.7 AIC16573.1 - 0.22 11.0 2.9 3.9 7.0 0.1 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1543) Ferritin PF00210.19 AIC16573.1 - 0.31 10.7 4.1 0.17 11.6 0.7 1.9 2 0 0 2 2 2 0 Ferritin-like domain UPF0150 PF03681.10 AIC16573.1 - 0.34 10.5 1.4 1.1 8.8 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0150) ApoO PF09769.4 AIC16573.1 - 0.7 9.5 5.9 0.91 9.2 3.4 1.8 1 1 1 2 2 2 0 Apolipoprotein O Clathrin_lg_ch PF01086.12 AIC16573.1 - 0.92 9.3 11.7 0.17 11.7 5.3 1.8 2 1 0 2 2 2 0 Clathrin light chain Phasin_2 PF09361.5 AIC16573.1 - 0.99 9.4 9.2 2.6 8.0 0.2 3.3 1 1 2 3 3 3 0 Phasin protein CDC37_N PF03234.9 AIC16573.1 - 1.8 8.8 8.9 1.4 9.2 4.8 1.7 1 1 0 1 1 1 0 Cdc37 N terminal kinase binding DUF1664 PF07889.7 AIC16573.1 - 2 8.2 5.7 0.87 9.3 1.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.4 AIC16573.1 - 2 7.2 7.5 3.4 6.5 5.2 1.3 1 0 0 1 1 1 0 UV radiation resistance protein and autophagy-related subunit 14 HisKA_3 PF07730.8 AIC16573.1 - 2.3 8.6 10.5 3.8 7.9 1.3 3.5 2 2 2 4 4 4 0 Histidine kinase TMEM51 PF15345.1 AIC16573.1 - 2.7 7.6 9.0 3.2 7.3 6.1 1.5 1 1 0 1 1 1 0 Transmembrane protein 51 DUF2229 PF09989.4 AIC16573.1 - 3.1 7.1 5.7 0.87 9.0 0.8 1.9 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) Mer2 PF09074.5 AIC16573.1 - 4.3 7.2 8.6 7.1 6.5 6.0 1.5 1 1 0 1 1 1 0 Mer2 DUF3391 PF11871.3 AIC16573.1 - 6.3 7.0 10.0 1.9 8.7 4.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) YtxH PF12732.2 AIC16573.1 - 7 7.1 7.7 33 4.9 1.9 2.8 2 1 0 2 2 2 0 YtxH-like protein PepSY PF03413.14 AIC16574.1 - 0.034 14.7 0.7 0.075 13.6 0.5 1.5 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain BAP PF06639.6 AIC16574.1 - 0.046 13.4 3.5 0.055 13.1 1.4 1.9 1 1 1 2 2 2 0 Basal layer antifungal peptide (BAP) DUF2700 PF10912.3 AIC16574.1 - 0.14 12.1 0.9 5.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2700) SpoIIIAH PF12685.2 AIC16574.1 - 2.6 7.5 13.8 5 6.5 9.6 1.5 1 1 0 1 1 1 0 SpoIIIAH-like protein DUF2267 PF10025.4 AIC16575.1 - 3.8e-10 39.8 0.1 4.4e-10 39.7 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) Bac_DNA_binding PF00216.16 AIC16575.1 - 0.0011 18.9 3.2 0.11 12.5 0.1 2.3 2 0 0 2 2 2 2 Bacterial DNA-binding protein IF2_N PF04760.10 AIC16575.1 - 0.002 17.7 1.0 0.036 13.7 0.6 2.3 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region DUF2780 PF11075.3 AIC16575.1 - 0.014 15.4 5.7 0.11 12.5 3.9 2.1 1 1 0 1 1 1 0 Protein of unknown function VcgC/VcgE (DUF2780) Mmp37 PF09139.6 AIC16575.1 - 0.067 12.2 1.9 0.077 12.0 1.3 1.1 1 0 0 1 1 1 0 Mitochondrial matrix Mmp37 Lin-8 PF03353.10 AIC16575.1 - 0.068 12.4 1.0 0.075 12.2 0.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2379 PF09543.5 AIC16575.1 - 0.13 12.2 1.4 1.5 8.7 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2379) Ribosomal_S13 PF00416.17 AIC16575.1 - 0.18 12.3 1.4 0.44 11.0 0.8 1.8 1 1 1 2 2 2 0 Ribosomal protein S13/S18 Trypan_glycop PF00913.14 AIC16575.1 - 0.23 10.3 4.7 0.28 10.0 3.2 1.0 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) HMG_CoA_synt_C PF08540.5 AIC16575.1 - 0.24 10.8 1.3 3.4 7.0 0.0 2.0 1 1 1 2 2 2 0 Hydroxymethylglutaryl-coenzyme A synthase C terminal YlbD_coat PF14071.1 AIC16575.1 - 1.1 9.3 4.5 7.6 6.6 0.1 2.3 1 1 0 2 2 2 0 Putative coat protein Lactamase_B PF00753.22 AIC16578.1 - 9.3e-07 28.6 0.3 1.9e-06 27.6 0.2 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.2 AIC16578.1 - 0.0022 17.5 0.0 0.0033 17.0 0.0 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TFIIS_C PF01096.13 AIC16579.1 - 0.034 13.7 0.1 0.045 13.3 0.1 1.3 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) Desulfoferrod_N PF06397.7 AIC16579.1 - 0.095 12.1 0.1 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain zf-RanBP PF00641.13 AIC16579.1 - 0.11 11.6 1.5 0.3 10.2 0.2 1.9 1 1 1 2 2 2 0 Zn-finger in Ran binding protein and others RVP PF00077.15 AIC16580.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.7 1 1 0 1 1 1 0 Retroviral aspartyl protease MerR-DNA-bind PF09278.6 AIC16582.1 - 0.095 13.1 1.7 1.2 9.5 0.6 2.3 1 1 0 1 1 1 0 MerR, DNA binding DUF3792 PF12670.2 AIC16583.1 - 0.046 13.5 0.6 0.066 13.0 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) Copper-bind PF00127.15 AIC16584.1 - 1e-08 35.2 0.8 0.0021 18.2 0.1 2.5 2 2 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC16584.1 - 7.3e-05 22.6 1.4 0.013 15.3 0.0 3.2 2 2 0 2 2 2 2 Cupredoxin-like domain DUF4095 PF13338.1 AIC16585.1 - 7.3e-23 81.0 0.0 1.3e-22 80.2 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4095) HTH_19 PF12844.2 AIC16585.1 - 0.066 13.2 0.2 9.4 6.3 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain DUF2624 PF11116.3 AIC16585.1 - 0.093 13.2 0.1 22 5.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2624) HTH_24 PF13412.1 AIC16585.1 - 0.14 11.5 0.3 0.72 9.2 0.1 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF1814 PF08843.6 AIC16586.1 - 2.2e-28 99.6 0.0 4e-28 98.7 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase of unknown function (DUF1814) BiPBP_C PF06832.7 AIC16587.1 - 0.034 14.0 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Penicillin-Binding Protein C-terminus Family GATase PF00117.23 AIC16588.1 - 9.4e-45 152.4 0.0 1.8e-44 151.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.17 AIC16588.1 - 2.6e-32 110.3 0.1 7.9e-32 108.8 0.0 1.9 2 0 0 2 2 2 1 GMP synthase C terminal domain NAD_synthase PF02540.12 AIC16588.1 - 4.6e-11 42.0 0.2 7.3e-06 25.0 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.8 AIC16588.1 - 4.2e-10 39.4 0.1 3.8e-09 36.3 0.0 2.5 2 1 0 2 2 2 1 Peptidase C26 Asn_synthase PF00733.16 AIC16588.1 - 9.9e-09 35.0 0.0 2.6e-08 33.6 0.0 1.6 2 0 0 2 2 2 1 Asparagine synthase ATP_bind_3 PF01171.15 AIC16588.1 - 1.6e-05 24.4 0.0 3e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 PP-loop family QueC PF06508.8 AIC16588.1 - 5.6e-05 22.5 0.0 0.00086 18.6 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 AIC16588.1 - 0.00041 19.8 0.1 0.0041 16.5 0.0 2.1 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.11 AIC16588.1 - 0.0019 16.8 0.0 0.007 14.9 0.0 1.8 2 0 0 2 2 2 1 tRNA methyl transferase PRANC PF09372.5 AIC16588.1 - 0.12 12.3 0.1 0.73 9.8 0.0 2.1 2 0 0 2 2 2 0 PRANC domain Mito_fiss_reg PF05308.6 AIC16589.1 - 0.00067 19.1 3.4 0.0009 18.6 2.4 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator DivIVA PF05103.8 AIC16589.1 - 0.0085 16.1 0.0 0.021 14.8 0.0 1.6 1 0 0 1 1 1 1 DivIVA protein DUF2360 PF10152.4 AIC16589.1 - 0.014 15.6 4.3 0.02 15.1 3.0 1.2 1 0 0 1 1 1 0 Predicted coiled-coil domain-containing protein (DUF2360) FAP PF07174.6 AIC16589.1 - 2.2 7.4 18.7 3.3 6.9 13.0 1.4 1 1 0 1 1 1 0 Fibronectin-attachment protein (FAP) DUF1443 PF07280.6 AIC16590.1 - 0.003 17.0 0.0 0.0046 16.4 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1443) DUF945 PF06097.6 AIC16590.1 - 0.0058 15.4 1.6 0.0058 15.4 1.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF945) TrbC PF04956.8 AIC16590.1 - 0.98 9.4 6.8 1.1 9.3 4.7 1.1 1 0 0 1 1 1 0 TrbC/VIRB2 family MAF_flag10 PF01973.13 AIC16591.1 - 2.8e-40 137.5 0.1 3.7e-40 137.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF115 TPK_catalytic PF04263.11 AIC16591.1 - 6.7e-06 25.6 1.0 0.00091 18.8 0.3 2.2 1 1 0 2 2 2 2 Thiamin pyrophosphokinase, catalytic domain DUF945 PF06097.6 AIC16593.1 - 0.1 11.3 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) DUF2562 PF10814.3 AIC16593.1 - 0.12 12.3 0.1 0.18 11.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2562) tRNA-synt_1 PF00133.17 AIC16598.1 - 1.6e-112 376.4 0.0 1.2e-111 373.6 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 AIC16598.1 - 5.8e-33 113.8 0.1 1.3e-32 112.7 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 AIC16598.1 - 1.3e-28 99.7 0.1 1.9e-15 56.4 0.0 3.4 3 0 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.1 AIC16598.1 - 0.00048 19.4 0.0 0.059 12.6 0.0 2.8 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 DZR PF12773.2 AIC16598.1 - 0.0036 17.0 0.7 1.2 9.0 0.2 2.5 2 0 0 2 2 2 1 Double zinc ribbon TF_Zn_Ribbon PF08271.7 AIC16598.1 - 0.0087 15.3 1.2 1.7 8.0 0.2 2.7 2 0 0 2 2 2 1 TFIIB zinc-binding zf-TFIIB PF13453.1 AIC16598.1 - 0.01 15.0 1.4 3.8 6.7 0.0 3.4 3 0 0 3 3 3 0 Transcription factor zinc-finger zf-ribbon_3 PF13248.1 AIC16598.1 - 0.012 14.8 5.6 1.5 8.1 1.1 2.7 2 0 0 2 2 2 0 zinc-ribbon domain tRNA-synt_1f PF01921.13 AIC16598.1 - 0.027 13.1 0.0 1 7.9 0.0 2.7 3 0 0 3 3 3 0 tRNA synthetases class I (K) tRNA-synt_1e PF01406.14 AIC16598.1 - 0.041 13.0 0.0 0.29 10.1 0.0 2.1 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain UPF0547 PF10571.4 AIC16598.1 - 0.12 12.1 3.9 3 7.6 0.0 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 DUF531 PF04407.7 AIC16598.1 - 0.13 12.1 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF531) zinc_ribbon_2 PF13240.1 AIC16598.1 - 0.43 10.1 8.4 5.3 6.6 0.1 2.8 2 1 0 2 2 2 0 zinc-ribbon domain Nudix_N_2 PF14803.1 AIC16598.1 - 1.5 8.5 4.4 2.5 7.8 0.0 2.8 3 0 0 3 3 3 0 Nudix N-terminal zf-FPG_IleRS PF06827.9 AIC16598.1 - 1.7 8.3 5.7 9.3 6.0 0.1 3.5 4 0 0 4 4 3 0 Zinc finger found in FPG and IleRS Zn-ribbon_8 PF09723.5 AIC16598.1 - 1.9 8.5 6.5 4.4 7.3 0.4 3.3 3 0 0 3 3 3 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 AIC16598.1 - 3.2 7.6 5.5 11 5.8 0.3 3.2 3 0 0 3 3 3 0 Transposase zinc-ribbon domain ADH_zinc_N PF00107.21 AIC16599.1 - 1.6e-33 115.0 3.4 3e-33 114.1 2.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AIC16599.1 - 7.8e-25 86.7 4.2 1.5e-24 85.8 2.9 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 AIC16599.1 - 2.5e-22 80.0 0.6 4.8e-22 79.1 0.4 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.3 AIC16599.1 - 0.0053 16.5 1.1 0.017 14.8 0.7 1.9 1 0 0 1 1 1 1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NADH_4Fe-4S PF10589.4 AIC16599.1 - 0.073 12.2 1.7 0.17 11.0 1.2 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region DUF4072 PF13284.1 AIC16599.1 - 0.16 12.1 1.9 0.23 11.6 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4072) Pterin_bind PF00809.17 AIC16601.1 - 2.4e-38 131.6 0.4 3.2e-37 127.9 0.3 2.1 1 1 0 1 1 1 1 Pterin binding enzyme IMPDH PF00478.20 AIC16602.1 - 5.8e-138 459.5 5.7 6.7e-138 459.3 4.0 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.23 AIC16602.1 - 5e-27 93.4 0.4 1.4e-13 50.3 0.0 3.0 2 0 0 2 2 2 2 CBS domain NMO PF03060.10 AIC16602.1 - 1e-14 54.4 8.3 2.1e-10 40.2 3.7 2.2 1 1 1 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.13 AIC16602.1 - 3e-07 29.5 11.6 2.2e-06 26.7 7.8 2.3 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.16 AIC16602.1 - 4.6e-06 26.0 2.3 0.0028 16.9 0.1 2.9 2 1 1 3 3 3 2 Histidine biosynthesis protein PEP_mutase PF13714.1 AIC16602.1 - 5.6e-05 22.4 0.7 0.022 13.9 0.1 2.4 2 0 0 2 2 2 2 Phosphoenolpyruvate phosphomutase DHO_dh PF01180.16 AIC16602.1 - 0.00095 18.2 4.7 0.0014 17.6 0.5 2.4 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase Radical_SAM PF04055.16 AIC16602.1 - 0.0021 18.2 0.1 0.4 10.8 0.0 2.8 2 1 1 3 3 3 1 Radical SAM superfamily FAD_binding_4 PF01565.18 AIC16602.1 - 0.0028 17.1 0.0 0.18 11.2 0.0 2.7 2 0 0 2 2 2 1 FAD binding domain Glu_synthase PF01645.12 AIC16602.1 - 0.028 13.3 3.3 0.051 12.4 2.3 1.4 1 0 0 1 1 1 0 Conserved region in glutamate synthase ThiG PF05690.9 AIC16602.1 - 0.13 11.3 2.5 0.2 10.6 0.3 2.1 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG EMP24_GP25L PF01105.19 AIC16603.1 - 0.00036 20.3 0.0 0.00046 19.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD PDT PF00800.13 AIC16605.1 - 2e-66 223.0 0.0 2.7e-66 222.5 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.20 AIC16605.1 - 1e-07 31.2 0.0 2.1e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 ACT domain CPSase_sm_chain PF00988.17 AIC16605.1 - 0.063 12.7 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain ECR1_N PF14382.1 AIC16606.1 - 1.6e-05 24.0 0.0 3.3e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.4 AIC16606.1 - 9.1e-05 22.3 0.1 0.0041 17.0 0.1 2.7 1 1 0 1 1 1 1 Exosome component EXOSC1/CSL4 Prok-RING_1 PF14446.1 AIC16606.1 - 0.024 14.3 0.9 0.039 13.6 0.6 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 AAA PF00004.24 AIC16607.1 - 5.7e-100 330.7 0.2 4.7e-51 172.4 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.13 AIC16607.1 - 5.1e-30 103.2 0.3 1.4e-29 101.8 0.2 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.9 AIC16607.1 - 6.8e-18 65.1 0.0 3.3e-08 33.6 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.7 AIC16607.1 - 5.4e-15 55.0 0.0 3.6e-09 36.0 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase ruvB N-terminus AAA_16 PF13191.1 AIC16607.1 - 4.6e-14 52.8 0.1 4.7e-07 29.9 0.0 3.2 2 1 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.1 AIC16607.1 - 1.6e-13 50.9 0.1 1.4e-05 25.2 0.0 4.2 2 2 0 2 2 2 2 AAA domain AAA_17 PF13207.1 AIC16607.1 - 1.6e-11 45.1 0.0 1.3e-05 25.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.8 AIC16607.1 - 4.7e-11 42.0 0.2 0.00012 20.9 0.0 2.3 2 0 0 2 2 2 2 TIP49 C-terminus AAA_14 PF13173.1 AIC16607.1 - 6.4e-11 42.2 0.0 1.6e-05 24.8 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.1 AIC16607.1 - 7.6e-11 42.0 0.0 0.00051 19.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.9 AIC16607.1 - 9e-11 41.6 0.9 0.00012 21.8 0.1 4.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.7 AIC16607.1 - 3.8e-10 39.1 0.0 6.3e-05 22.1 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin IstB_IS21 PF01695.12 AIC16607.1 - 1.3e-08 34.4 0.2 0.0032 16.9 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein CDC48_2 PF02933.12 AIC16607.1 - 4.9e-08 32.4 0.1 1.2e-07 31.2 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 Sigma54_activat PF00158.21 AIC16607.1 - 5.9e-08 32.3 0.4 0.027 13.9 0.0 3.6 3 1 0 3 3 3 2 Sigma-54 interaction domain Bac_DnaA PF00308.13 AIC16607.1 - 5.7e-07 29.4 0.0 0.0011 18.6 0.0 2.7 2 0 0 2 2 2 2 Bacterial dnaA protein Arch_ATPase PF01637.13 AIC16607.1 - 5.7e-07 29.4 0.0 0.0014 18.3 0.1 3.8 2 2 2 4 4 4 2 Archaeal ATPase KaiC PF06745.8 AIC16607.1 - 7e-07 28.5 0.5 0.1 11.6 0.0 3.7 2 1 1 3 3 3 2 KaiC NACHT PF05729.7 AIC16607.1 - 9.6e-07 28.6 0.1 0.13 11.8 0.0 4.0 4 0 0 4 4 4 2 NACHT domain RNA_helicase PF00910.17 AIC16607.1 - 1.3e-06 28.5 0.0 0.035 14.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.16 AIC16607.1 - 1.4e-06 27.6 2.2 0.033 13.3 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_25 PF13481.1 AIC16607.1 - 1.6e-06 27.6 5.5 0.59 9.4 0.2 4.1 2 2 1 3 3 3 3 AAA domain AAA_28 PF13521.1 AIC16607.1 - 1.7e-06 28.1 0.0 0.011 15.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_19 PF13245.1 AIC16607.1 - 4e-06 26.4 4.4 0.0051 16.5 0.1 3.3 3 0 0 3 3 3 2 Part of AAA domain PhoH PF02562.11 AIC16607.1 - 1.1e-05 24.7 0.7 0.11 11.7 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein AAA_18 PF13238.1 AIC16607.1 - 2.1e-05 24.8 0.0 0.035 14.3 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.1 AIC16607.1 - 2.7e-05 23.8 0.1 0.021 14.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activ_2 PF14532.1 AIC16607.1 - 4.3e-05 23.5 0.0 0.097 12.7 0.0 2.5 2 0 0 2 2 2 2 Sigma-54 interaction domain DUF815 PF05673.8 AIC16607.1 - 6.9e-05 21.8 0.0 0.043 12.7 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) NB-ARC PF00931.17 AIC16607.1 - 7e-05 21.8 0.1 0.091 11.6 0.0 2.3 2 0 0 2 2 2 2 NB-ARC domain ABC_tran PF00005.22 AIC16607.1 - 8.5e-05 22.8 0.0 0.66 10.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_3 PF07726.6 AIC16607.1 - 0.00058 19.4 0.0 0.38 10.3 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AFG1_ATPase PF03969.11 AIC16607.1 - 0.00064 18.6 0.1 0.22 10.3 0.1 2.8 2 1 0 2 2 2 1 AFG1-like ATPase NTPase_1 PF03266.10 AIC16607.1 - 0.00068 19.3 0.3 4 7.1 0.0 3.6 2 1 1 3 3 3 0 NTPase SKI PF01202.17 AIC16607.1 - 0.00095 19.0 0.2 0.49 10.2 0.0 2.7 3 0 0 3 3 2 1 Shikimate kinase DUF2075 PF09848.4 AIC16607.1 - 0.0011 18.0 0.0 0.32 9.9 0.0 2.5 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.12 AIC16607.1 - 0.0014 17.5 0.1 0.25 10.1 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 ATP-synt_ab PF00006.20 AIC16607.1 - 0.0015 18.0 0.0 1.4 8.4 0.0 2.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain T2SE PF00437.15 AIC16607.1 - 0.0017 17.3 0.0 1.7 7.4 0.0 2.3 2 0 0 2 2 2 2 Type II/IV secretion system protein UPF0079 PF02367.12 AIC16607.1 - 0.0018 17.9 0.1 2.5 7.7 0.0 2.4 2 0 0 2 2 2 2 Uncharacterised P-loop hydrolase UPF0079 AAA_30 PF13604.1 AIC16607.1 - 0.0019 17.8 0.1 1.8 8.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain ResIII PF04851.10 AIC16607.1 - 0.0053 16.6 0.0 2.1 8.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Guanylate_kin PF00625.16 AIC16607.1 - 0.0057 16.1 0.2 4.2 6.7 0.0 3.4 2 1 1 3 3 3 0 Guanylate kinase AAA_11 PF13086.1 AIC16607.1 - 0.019 14.5 0.0 0.94 9.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.4 AIC16607.1 - 0.02 14.4 0.1 6.8 6.1 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation KAP_NTPase PF07693.9 AIC16607.1 - 0.023 13.6 0.1 1.8 7.4 0.0 2.7 2 1 1 3 3 3 0 KAP family P-loop domain Viral_helicase1 PF01443.13 AIC16607.1 - 0.029 13.8 0.0 1.3 8.4 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_29 PF13555.1 AIC16607.1 - 0.047 13.2 0.5 7.7 6.1 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain CPT PF07931.7 AIC16607.1 - 0.05 13.2 0.0 5.2 6.6 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_10 PF12846.2 AIC16607.1 - 0.068 12.6 0.4 13 5.1 0.0 3.2 2 2 0 2 2 2 0 AAA-like domain IPT PF01745.11 AIC16607.1 - 0.089 11.9 0.2 10 5.1 0.0 2.4 2 0 0 2 2 2 0 Isopentenyl transferase DUF258 PF03193.11 AIC16607.1 - 0.1 11.7 0.0 6.4 5.9 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF258 AAA_23 PF13476.1 AIC16607.1 - 0.13 12.5 0.2 17 5.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain DEAD PF00270.24 AIC16607.1 - 0.13 11.7 2.4 26 4.2 0.0 3.7 4 1 1 5 5 3 0 DEAD/DEAH box helicase PIF1 PF05970.9 AIC16607.1 - 0.15 10.9 0.0 16 4.2 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase Torsin PF06309.6 AIC16607.1 - 0.24 11.3 0.1 13 5.6 0.0 2.4 2 0 0 2 2 2 0 Torsin Orn_Arg_deC_N PF02784.11 AIC16608.1 - 3.5e-38 131.2 0.0 4.3e-38 130.9 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.17 AIC16608.1 - 1.9e-09 37.2 0.1 3.8e-09 36.2 0.1 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Acylphosphatase PF00708.13 AIC16609.1 - 6.6e-30 103.0 0.1 7.2e-30 102.9 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase His_biosynth PF00977.16 AIC16611.1 - 9.6e-86 286.7 1.8 1.1e-85 286.5 1.2 1.1 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.12 AIC16611.1 - 1.2e-08 34.1 0.1 7.3e-05 21.7 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) PcrB PF01884.12 AIC16611.1 - 3.7e-06 26.3 1.9 2.6e-05 23.5 0.2 2.5 2 1 1 3 3 3 1 PcrB family ThiG PF05690.9 AIC16611.1 - 7.6e-06 25.1 0.8 0.02 13.9 0.2 2.1 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG NMO PF03060.10 AIC16611.1 - 1.9e-05 24.0 0.5 0.052 12.6 0.0 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase TMP-TENI PF02581.12 AIC16611.1 - 0.00026 20.1 0.2 0.67 9.0 0.0 2.3 2 0 0 2 2 2 2 Thiamine monophosphate synthase/TENI DHO_dh PF01180.16 AIC16611.1 - 0.00082 18.4 0.1 0.079 11.9 0.0 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase Trp_syntA PF00290.15 AIC16611.1 - 0.027 13.0 0.1 0.049 12.1 0.1 1.4 1 0 0 1 1 1 0 Tryptophan synthase alpha chain His_biosynth PF00977.16 AIC16612.1 - 5.8e-67 225.2 5.1 6.6e-67 225.1 3.6 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.12 AIC16612.1 - 4.1e-09 36.0 5.8 0.00012 21.3 0.2 2.8 2 1 1 3 3 3 2 PcrB family Dus PF01207.12 AIC16612.1 - 1e-07 31.1 1.4 2.3e-05 23.4 0.2 2.3 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) DHO_dh PF01180.16 AIC16612.1 - 1.8e-05 23.8 1.7 0.00056 18.9 0.3 2.1 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase IGPS PF00218.16 AIC16612.1 - 0.00013 21.1 0.3 0.38 9.7 0.0 2.4 2 0 0 2 2 2 2 Indole-3-glycerol phosphate synthase ThiG PF05690.9 AIC16612.1 - 0.001 18.1 5.3 0.0024 16.9 0.5 2.3 2 1 0 2 2 2 1 Thiazole biosynthesis protein ThiG CutC PF03932.9 AIC16612.1 - 0.0038 16.4 0.4 2.1 7.5 0.0 3.0 2 1 1 3 3 3 1 CutC family Pterin_bind PF00809.17 AIC16612.1 - 0.0066 15.8 0.6 0.013 14.9 0.4 1.5 1 1 0 1 1 1 1 Pterin binding enzyme NanE PF04131.9 AIC16612.1 - 0.0072 15.3 3.0 1.1 8.2 0.2 2.3 1 1 1 2 2 2 2 Putative N-acetylmannosamine-6-phosphate epimerase Oxidored_FMN PF00724.15 AIC16612.1 - 0.009 15.0 0.1 0.012 14.6 0.1 1.2 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Trp_syntA PF00290.15 AIC16612.1 - 0.012 14.1 2.3 0.074 11.5 0.1 2.4 3 0 0 3 3 3 0 Tryptophan synthase alpha chain FMN_dh PF01070.13 AIC16612.1 - 0.016 14.0 4.0 0.042 12.6 0.3 2.2 2 0 0 2 2 2 0 FMN-dependent dehydrogenase PEP_mutase PF13714.1 AIC16612.1 - 0.026 13.7 1.1 0.058 12.6 0.4 1.8 2 0 0 2 2 2 0 Phosphoenolpyruvate phosphomutase F420_oxidored PF03807.12 AIC16612.1 - 0.04 14.3 2.2 1.1 9.6 1.5 2.9 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent DUF4406 PF14359.1 AIC16612.1 - 0.045 13.8 0.0 0.12 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4406) Peptidase_C80 PF11713.3 AIC16612.1 - 0.09 12.5 0.0 0.24 11.1 0.0 1.7 2 0 0 2 2 2 0 Peptidase C80 family DUF1471 PF07338.8 AIC16612.1 - 0.44 10.2 2.8 6.9 6.3 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1471) GATase PF00117.23 AIC16613.1 - 2.7e-33 115.0 0.0 3e-33 114.8 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AIC16613.1 - 9.3e-10 38.3 0.0 2.9e-08 33.4 0.0 2.3 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.9 AIC16613.1 - 5.5e-09 35.8 0.0 8.1e-09 35.2 0.0 1.3 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.14 AIC16613.1 - 1.5e-06 27.9 0.0 1.8e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family IGPD PF00475.13 AIC16614.1 - 4.4e-46 156.3 1.7 6.9e-46 155.7 1.2 1.3 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase HAD_2 PF13419.1 AIC16615.1 - 4e-07 30.4 0.1 0.0068 16.6 0.0 2.4 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase HAD PF12710.2 AIC16615.1 - 2.9e-05 24.3 0.1 4.5e-05 23.7 0.0 1.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AIC16615.1 - 3.7e-05 24.2 0.1 0.00014 22.3 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.1 AIC16615.1 - 0.00049 19.7 0.0 0.00087 18.9 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like PNK3P PF08645.6 AIC16615.1 - 0.027 13.9 0.1 4.6 6.6 0.0 2.4 2 0 0 2 2 2 0 Polynucleotide kinase 3 phosphatase Aminotran_1_2 PF00155.16 AIC16616.1 - 7e-43 146.9 0.0 8.1e-43 146.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.8 AIC16616.1 - 8.2e-08 31.2 0.0 1.4e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.14 AIC16616.1 - 0.0017 17.1 0.0 0.012 14.3 0.0 1.9 2 0 0 2 2 2 1 Aminotransferase class-V DUF3294 PF07957.6 AIC16616.1 - 0.12 11.9 0.1 0.24 10.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) Histidinol_dh PF00815.15 AIC16617.1 - 3.7e-134 447.4 8.1 4.7e-134 447.0 5.6 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase HisG PF01634.13 AIC16618.1 - 1e-36 126.0 0.1 1.3e-36 125.5 0.1 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.6 AIC16618.1 - 1.1e-15 57.2 0.0 2.5e-15 56.1 0.0 1.6 1 0 0 1 1 1 1 HisG, C-terminal domain HMG-CoA_red PF00368.13 AIC16619.1 - 2.1e-87 293.2 12.6 2.6e-87 292.9 8.8 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Chlorosome_CsmC PF11098.3 AIC16619.1 - 0.0079 15.9 2.1 0.02 14.6 0.0 2.7 3 1 1 4 4 4 1 Chlorosome envelope protein C Spore_coat_CotO PF14153.1 AIC16619.1 - 0.23 10.8 0.5 0.39 10.1 0.4 1.3 1 0 0 1 1 1 0 Spore coat protein CotO DUF3759 PF12585.3 AIC16619.1 - 0.59 10.0 3.7 3.2 7.6 2.5 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3759) Zn-ribbon_8 PF09723.5 AIC16620.1 - 0.64 10.0 2.4 1.4 8.9 1.7 1.6 1 1 0 1 1 1 0 Zinc ribbon domain Prok-RING_1 PF14446.1 AIC16621.1 - 0.0051 16.5 6.5 0.0085 15.8 4.5 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 C1_1 PF00130.17 AIC16621.1 - 0.0053 16.4 5.6 0.007 16.0 3.9 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.2 AIC16621.1 - 0.66 9.8 8.1 2.4 8.0 5.6 1.9 1 1 1 2 2 2 0 Double zinc ribbon zf-RING_5 PF14634.1 AIC16621.1 - 0.81 9.4 7.8 0.27 10.9 1.6 2.0 1 1 0 1 1 1 0 zinc-RING finger domain IBR PF01485.16 AIC16621.1 - 3 7.7 11.3 14 5.6 7.8 1.9 1 1 0 1 1 1 0 IBR domain zf-B_box PF00643.19 AIC16621.1 - 9.2 6.2 9.9 20 5.1 6.8 1.6 1 1 0 1 1 1 0 B-box zinc finger Cupredoxin_1 PF13473.1 AIC16622.1 - 7.7e-12 45.0 0.3 1.3e-11 44.2 0.2 1.4 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.15 AIC16622.1 - 1.2e-09 38.2 0.1 2.1e-09 37.5 0.1 1.3 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family GSDH PF07995.6 AIC16623.1 - 1.5e-90 303.6 0.0 2.4e-90 302.9 0.0 1.2 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Reg_prop PF07494.6 AIC16623.1 - 0.0019 17.9 0.4 5.5 7.3 0.0 4.2 4 0 0 4 4 4 1 Two component regulator propeller SGL PF08450.7 AIC16623.1 - 0.016 14.5 0.0 0.12 11.7 0.0 2.3 2 1 1 3 3 3 0 SMP-30/Gluconolaconase/LRE-like region CBS PF00571.23 AIC16624.1 - 2.3e-34 116.9 6.0 1.2e-12 47.4 0.4 4.3 4 0 0 4 4 4 4 CBS domain Ribosomal_S30AE PF02482.14 AIC16624.1 - 2.2e-06 28.0 1.3 5.7e-06 26.6 0.9 1.7 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein zf-C2H2_4 PF13894.1 AIC16625.1 - 0.048 13.9 0.2 0.074 13.4 0.1 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger Ribosomal_S14 PF00253.16 AIC16626.1 - 0.012 14.9 0.2 0.017 14.5 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein S14p/S29e PyrI_C PF02748.10 AIC16626.1 - 0.06 12.7 2.6 0.089 12.2 1.8 1.3 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zinc_ribbon_6 PF14599.1 AIC16626.1 - 0.083 12.6 0.5 0.12 12.1 0.3 1.5 1 1 0 1 1 1 0 Zinc-ribbon zf-UBR PF02207.15 AIC16626.1 - 0.2 11.4 4.4 1.5 8.6 0.9 2.1 1 1 1 2 2 2 0 Putative zinc finger in N-recognin (UBR box) DUF1922 PF09082.5 AIC16626.1 - 0.46 10.5 0.2 0.46 10.5 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1922) eIF-1a PF01176.14 AIC16627.1 - 3.4e-22 77.6 1.1 4.1e-22 77.3 0.7 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.14 AIC16627.1 - 0.011 15.3 1.7 0.037 13.7 0.4 2.1 2 1 0 2 2 2 0 Myosin N-terminal SH3-like domain 60KD_IMP PF02096.15 AIC16629.1 - 0.027 14.1 3.9 0.039 13.6 2.7 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein DUF929 PF06053.6 AIC16629.1 - 0.11 11.6 2.9 0.14 11.2 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Sigma_reg_N PF13800.1 AIC16629.1 - 0.18 11.8 2.1 0.29 11.1 1.5 1.3 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Abhydrolase_9_N PF15420.1 AIC16629.1 - 0.41 10.3 6.3 0.37 10.4 3.6 1.5 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF454 PF04304.8 AIC16629.1 - 1.3 9.1 3.9 2.5 8.2 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF454) NdhO PF11910.3 AIC16630.1 - 0.026 14.1 0.0 0.026 14.1 0.0 1.1 1 0 0 1 1 1 0 Cyanobacterial and plant NDH-1 subunit O Pyridox_oxidase PF01243.15 AIC16631.1 - 1.3e-15 57.1 0.0 1.8e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 AIC16631.1 - 1.2e-07 31.6 0.0 1.5e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Bac_luciferase PF00296.15 AIC16632.1 - 6.8e-57 192.9 0.0 8.6e-57 192.5 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Methyltransf_2 PF00891.13 AIC16633.1 - 1.1e-61 208.1 0.0 1.4e-61 207.7 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_18 PF12847.2 AIC16633.1 - 0.00015 22.2 0.0 0.00028 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC16633.1 - 0.00016 21.4 0.0 0.00028 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain HTH_IclR PF09339.5 AIC16633.1 - 0.00084 18.8 0.0 0.0018 17.8 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_20 PF12840.2 AIC16633.1 - 0.011 15.5 0.0 0.028 14.2 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Methyltransf_12 PF08242.7 AIC16633.1 - 0.013 15.9 0.0 0.024 15.0 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.9 AIC16633.1 - 0.016 14.6 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain TrmB PF01978.14 AIC16633.1 - 0.016 14.9 0.0 0.041 13.5 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_45 PF14947.1 AIC16633.1 - 0.017 14.9 0.0 0.059 13.2 0.0 1.9 2 0 0 2 2 2 0 Winged helix-turn-helix Methyltransf_31 PF13847.1 AIC16633.1 - 0.023 14.3 0.0 0.054 13.0 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain MarR_2 PF12802.2 AIC16633.1 - 0.083 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 MarR family Epsilon_antitox PF08998.6 AIC16634.1 - 0.079 12.9 0.0 0.12 12.3 0.0 1.3 1 1 0 1 1 1 0 Bacterial epsilon antitoxin PG_binding_1 PF01471.13 AIC16636.1 - 3.4e-64 212.6 4.3 2.5e-18 65.7 0.0 4.7 5 0 0 5 5 5 4 Putative peptidoglycan binding domain PG_binding_3 PF09374.5 AIC16636.1 - 1.9e-25 88.6 2.3 0.0019 18.1 0.0 7.5 5 3 3 8 8 8 6 Predicted Peptidoglycan domain Exo_endo_phos PF03372.18 AIC16637.1 - 2.7e-22 79.9 0.0 3.1e-22 79.7 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Swi3 PF07962.7 AIC16637.1 - 0.025 14.2 0.2 0.079 12.5 0.0 1.9 2 0 0 2 2 2 0 Replication Fork Protection Component Swi3 Exo_endo_phos_2 PF14529.1 AIC16637.1 - 0.045 13.3 0.0 0.51 9.9 0.0 2.6 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF1129 PF06570.6 AIC16638.1 - 0.21 10.8 3.0 0.22 10.8 2.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DUF3671 PF12420.3 AIC16638.1 - 0.34 10.9 3.0 0.34 10.8 1.8 1.3 1 1 0 1 1 1 0 Protein of unknown function Tetraspannin PF00335.15 AIC16638.1 - 0.38 9.9 6.1 0.46 9.7 4.2 1.1 1 0 0 1 1 1 0 Tetraspanin family SdpI PF13630.1 AIC16638.1 - 3.1 7.5 11.3 0.61 9.8 1.1 2.2 1 1 1 2 2 2 0 SdpI/YhfL protein family DUF2244 PF10003.4 AIC16638.1 - 3.9 6.8 6.1 7.5 5.9 4.2 1.5 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Fer4 PF00037.22 AIC16642.1 - 3.9e-09 35.7 12.3 4.6e-06 25.9 1.1 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.2 AIC16642.1 - 1.8e-08 34.6 29.3 1.8e-05 24.9 7.8 2.2 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_8 PF13183.1 AIC16642.1 - 9.7e-08 31.9 23.3 5.1e-05 23.2 5.8 2.1 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_9 PF13187.1 AIC16642.1 - 8.6e-07 29.1 7.3 3.5e-06 27.1 5.0 1.9 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.2 AIC16642.1 - 9.5e-07 28.4 12.8 0.002 17.9 2.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.2 AIC16642.1 - 1.3e-06 27.9 11.5 0.0055 16.5 1.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.1 AIC16642.1 - 2e-06 27.4 19.7 3.8e-05 23.4 6.5 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.1 AIC16642.1 - 4.4e-06 26.9 9.6 0.00017 21.8 3.8 2.2 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_18 PF13746.1 AIC16642.1 - 1.6e-05 25.1 8.2 9.1e-05 22.8 4.2 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.1 AIC16642.1 - 1.9e-05 24.4 7.9 0.00085 19.1 5.5 2.2 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_4 PF12800.2 AIC16642.1 - 3.8e-05 23.6 6.6 0.027 14.7 1.0 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.1 AIC16642.1 - 9.1e-05 22.9 7.7 0.094 13.2 1.6 2.6 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_16 PF13484.1 AIC16642.1 - 0.00011 22.8 7.3 0.004 17.8 5.8 2.3 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_13 PF13370.1 AIC16642.1 - 0.00086 19.6 8.7 0.12 12.7 0.3 2.8 3 0 0 3 3 3 2 4Fe-4S single cluster domain Fer4_11 PF13247.1 AIC16642.1 - 0.0047 16.7 0.7 2 8.3 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.2 AIC16642.1 - 0.055 14.0 16.2 0.2 12.2 1.2 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain RRN7 PF11781.3 AIC16643.1 - 0.033 13.6 0.1 0.067 12.7 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 Brevenin PF03032.10 AIC16643.1 - 0.63 9.9 2.1 1.1 9.2 1.4 1.4 1 0 0 1 1 1 0 Brevenin/esculentin/gaegurin/rugosin family ArsA_ATPase PF02374.10 AIC16644.1 - 1.4e-67 227.9 0.0 1.6e-67 227.7 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.18 AIC16644.1 - 1.2e-10 41.1 0.1 5.9e-10 38.8 0.0 2.2 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.1 AIC16644.1 - 6.7e-05 22.8 0.0 0.00016 21.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain Fer4_NifH PF00142.13 AIC16644.1 - 0.00046 19.4 0.0 0.00085 18.5 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PhoH PF02562.11 AIC16644.1 - 0.021 14.0 0.0 0.032 13.4 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.1 AIC16644.1 - 0.034 13.9 1.1 0.081 12.6 0.7 1.6 1 0 0 1 1 1 0 Part of AAA domain IstB_IS21 PF01695.12 AIC16644.1 - 0.038 13.4 0.2 0.07 12.5 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein ArgK PF03308.11 AIC16644.1 - 0.079 11.7 0.1 0.18 10.5 0.0 1.6 2 0 0 2 2 2 0 ArgK protein Ammonium_transp PF00909.16 AIC16645.1 - 1e-110 369.9 29.9 1.2e-110 369.7 20.7 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DegT_DnrJ_EryC1 PF01041.12 AIC16646.1 - 1.5e-123 412.4 0.6 1.7e-123 412.3 0.4 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.16 AIC16646.1 - 8.2e-08 31.5 0.0 1.5e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.16 AIC16646.1 - 3.3e-06 26.4 2.3 6.3e-06 25.5 1.6 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 AIC16646.1 - 2.7e-05 22.6 0.0 4.2e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.14 AIC16646.1 - 0.00014 20.7 0.6 0.00021 20.1 0.1 1.4 2 0 0 2 2 2 1 Aminotransferase class-V OKR_DC_1 PF01276.15 AIC16646.1 - 0.0012 17.4 0.0 0.0016 17.0 0.0 1.1 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain ComK PF06338.6 AIC16646.1 - 0.038 13.4 0.0 0.06 12.7 0.0 1.3 1 0 0 1 1 1 0 ComK protein Pyr_redox_2 PF07992.9 AIC16646.1 - 0.1 12.4 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh PF00984.14 AIC16647.1 - 2.7e-18 65.9 0.0 5e-18 65.1 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.9 AIC16647.1 - 3.8e-10 39.4 0.0 3e-05 23.4 0.0 2.1 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.10 AIC16647.1 - 0.00016 21.5 0.0 0.0003 20.6 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 AIC16647.1 - 0.00017 21.2 0.7 0.0003 20.5 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 AIC16647.1 - 0.0015 17.7 0.1 0.0023 17.1 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TrkA_N PF02254.13 AIC16647.1 - 0.037 14.0 0.1 0.12 12.4 0.0 1.9 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_18 PF12847.2 AIC16647.1 - 0.041 14.4 0.0 0.41 11.2 0.0 2.2 1 1 1 2 2 2 0 Methyltransferase domain TPMT PF05724.6 AIC16647.1 - 0.042 13.2 0.0 0.062 12.7 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NAD_binding_7 PF13241.1 AIC16647.1 - 0.082 13.1 0.0 0.19 11.9 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding Methyltransf_23 PF13489.1 AIC16647.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Polysacc_deac_1 PF01522.16 AIC16648.1 - 8.3e-13 48.0 0.0 1.2e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase Cas_GSU0054 PF09609.5 AIC16648.1 - 0.019 13.8 0.0 0.027 13.3 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein, GSU0054 family (Cas_GSU0054) Glycos_transf_2 PF00535.21 AIC16649.1 - 6.6e-33 113.7 0.3 1e-32 113.1 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AIC16649.1 - 2.3e-30 106.1 0.4 1.7e-29 103.2 0.3 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.10 AIC16649.1 - 4.1e-18 65.0 0.0 4.1e-18 65.0 0.0 2.0 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.1 AIC16649.1 - 1.3e-14 54.3 7.5 1.3e-14 54.3 5.2 2.7 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 AIC16649.1 - 1.3e-08 34.3 0.3 2.4e-06 26.9 0.0 2.3 1 1 1 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 AIC16649.1 - 8e-08 31.6 0.2 1.2e-07 31.1 0.2 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 AIC16649.1 - 0.0018 18.5 0.0 0.0039 17.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 Fringe PF02434.11 AIC16649.1 - 0.073 12.2 0.2 0.55 9.3 0.0 2.0 2 0 0 2 2 2 0 Fringe-like TraP PF07296.6 AIC16649.1 - 0.3 10.0 3.2 0.51 9.2 0.6 2.1 2 0 0 2 2 2 0 TraP protein zf-C2H2_2 PF12756.2 AIC16650.1 - 0.055 13.5 0.1 0.064 13.3 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) UDPG_MGDP_dh PF00984.14 AIC16651.1 - 5.6e-17 61.7 0.0 1.1e-16 60.7 0.0 1.5 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.9 AIC16651.1 - 2.3e-10 40.1 0.0 1.4e-05 24.5 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.10 AIC16651.1 - 6.7e-05 22.7 0.2 0.00014 21.7 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.13 AIC16651.1 - 0.0002 21.0 1.0 0.00048 19.8 0.1 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.14 AIC16651.1 - 0.0037 16.4 0.5 0.006 15.7 0.0 1.5 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPMT PF05724.6 AIC16651.1 - 0.0095 15.3 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) TrkA_N PF02254.13 AIC16651.1 - 0.014 15.3 0.5 0.08 12.9 0.1 2.2 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_23 PF13489.1 AIC16651.1 - 0.064 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Beta_propel PF09826.4 AIC16651.1 - 0.098 10.9 0.0 0.13 10.5 0.0 1.1 1 0 0 1 1 1 0 Beta propeller domain NAD_binding_8 PF13450.1 AIC16651.1 - 0.1 12.6 0.0 0.75 9.8 0.0 2.4 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Methyltransf_18 PF12847.2 AIC16651.1 - 0.13 12.8 0.0 1.4 9.5 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Polysacc_deac_1 PF01522.16 AIC16652.1 - 4.3e-11 42.5 0.0 6.7e-11 41.8 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase Glycos_transf_2 PF00535.21 AIC16653.1 - 2e-35 121.9 0.3 3e-35 121.3 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.1 AIC16653.1 - 3.2e-28 99.0 0.4 5.6e-27 95.0 0.3 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.10 AIC16653.1 - 8.8e-15 54.0 4.6 8.5e-14 50.8 3.2 2.2 1 1 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.1 AIC16653.1 - 9e-12 45.0 8.2 9e-12 45.0 5.7 2.7 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.1 AIC16653.1 - 8e-08 31.7 0.1 8.1e-06 25.2 0.0 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.4 AIC16653.1 - 5.9e-06 25.5 0.1 8.6e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.1 AIC16653.1 - 0.0053 17.0 0.0 0.017 15.4 0.0 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 CofC PF01983.11 AIC16653.1 - 0.087 11.7 0.1 0.13 11.1 0.1 1.2 1 0 0 1 1 1 0 Guanylyl transferase CofC like zf-C2H2_2 PF12756.2 AIC16654.1 - 0.045 13.8 0.1 0.064 13.3 0.1 1.4 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Fil_haemagg PF05594.9 AIC16656.1 - 0.17 12.1 16.0 3.4 8.0 11.1 2.1 1 1 0 1 1 1 0 Haemagluttinin repeat eIF-5_eIF-2B PF01873.12 AIC16657.1 - 2.4e-29 101.4 0.0 2.9e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.7 AIC16657.1 - 2.3e-05 23.6 0.8 4.2e-05 22.7 0.5 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Lar_restr_allev PF14354.1 AIC16657.1 - 0.00033 20.8 0.4 0.00054 20.1 0.3 1.3 1 0 0 1 1 1 1 Restriction alleviation protein Lar Prim_Zn_Ribbon PF08273.7 AIC16657.1 - 0.024 14.7 0.8 0.063 13.3 0.6 1.7 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase Cys_rich_KTR PF14205.1 AIC16657.1 - 0.025 14.0 2.1 0.46 9.9 0.1 2.6 2 1 1 3 3 3 0 Cysteine-rich KTR Elf1 PF05129.8 AIC16657.1 - 0.045 13.4 0.1 0.064 12.9 0.1 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like SUI1 PF01253.17 AIC16657.1 - 0.13 12.1 0.0 15 5.5 0.0 2.3 2 0 0 2 2 2 0 Translation initiation factor SUI1 DZR PF12773.2 AIC16657.1 - 0.22 11.3 1.1 0.67 9.8 0.8 1.7 1 1 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC16657.1 - 0.23 10.6 3.9 2.2 7.6 2.8 2.1 1 1 1 2 2 2 0 zinc-ribbon domain Prok-RING_1 PF14446.1 AIC16657.1 - 0.85 9.4 3.3 3.5 7.4 0.2 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C2H2_2 PF12756.2 AIC16658.1 - 0.022 14.8 0.1 0.029 14.4 0.0 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) Phage_int_SAM_1 PF02899.12 AIC16659.1 - 0.044 13.9 0.1 16 5.6 0.0 3.0 3 0 0 3 3 3 0 Phage integrase, N-terminal SAM-like domain Ribosomal_L35Ae PF01247.13 AIC16660.1 - 0.089 12.5 0.1 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L35Ae Thioredoxin PF00085.15 AIC16661.1 - 1.8e-29 101.4 0.0 2.7e-29 100.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 AIC16661.1 - 6.7e-09 35.9 0.2 6.3e-08 32.8 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 AIC16661.1 - 2.8e-07 30.5 0.0 1.3e-05 25.2 0.0 2.5 2 1 1 3 3 3 1 Thioredoxin-like Redoxin PF08534.5 AIC16661.1 - 8.8e-05 22.0 0.1 0.00036 20.1 0.0 1.9 1 1 1 2 2 2 1 Redoxin Thioredoxin_9 PF14595.1 AIC16661.1 - 0.00099 18.6 0.0 0.0014 18.2 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 AIC16661.1 - 0.008 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_3 PF13192.1 AIC16661.1 - 0.01 15.5 0.4 0.019 14.7 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin domain HyaE PF07449.6 AIC16661.1 - 0.012 15.5 0.0 0.024 14.5 0.0 1.4 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE AhpC-TSA PF00578.16 AIC16661.1 - 0.072 12.7 0.0 0.14 11.8 0.0 1.5 1 1 0 1 1 1 0 AhpC/TSA family Glutaredoxin PF00462.19 AIC16661.1 - 0.091 12.7 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin TraF PF13728.1 AIC16661.1 - 0.11 12.0 0.1 0.28 10.6 0.0 1.6 2 0 0 2 2 2 0 F plasmid transfer operon protein CcdB PF01845.12 AIC16661.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 CcdB protein GrpE PF01025.14 AIC16662.1 - 3.1e-41 140.6 2.3 3.8e-41 140.4 1.6 1.0 1 0 0 1 1 1 1 GrpE DUF3373 PF11853.3 AIC16662.1 - 0.027 13.0 0.3 0.026 13.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3373) DUF3166 PF11365.3 AIC16662.1 - 0.03 14.7 1.9 0.057 13.8 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3166) AAA_13 PF13166.1 AIC16662.1 - 0.03 12.7 1.5 0.039 12.4 1.0 1.0 1 0 0 1 1 1 0 AAA domain Apolipoprotein PF01442.13 AIC16662.1 - 0.032 13.7 2.7 0.046 13.2 1.9 1.2 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Endotoxin_N PF03945.9 AIC16662.1 - 0.076 12.3 0.7 0.11 11.8 0.5 1.2 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain DLD PF14878.1 AIC16662.1 - 0.085 12.9 4.4 0.16 12.0 3.1 1.5 1 0 0 1 1 1 0 Death-like domain of SPT6 DUF730 PF05325.6 AIC16662.1 - 0.23 11.2 1.3 0.37 10.6 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF730) DUF1843 PF08898.5 AIC16662.1 - 0.84 9.7 5.2 13 5.9 0.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1843) DUF1451 PF07295.6 AIC16662.1 - 1.4 8.6 4.5 2 8.1 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) DUF883 PF05957.8 AIC16662.1 - 8.3 6.8 6.8 4.2 7.8 0.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) HSP70 PF00012.15 AIC16663.1 - 1e-214 713.9 17.0 1.2e-195 650.9 8.3 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.8 AIC16663.1 - 9.3e-17 60.6 4.7 2.7e-16 59.1 3.2 1.8 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.11 AIC16663.1 - 3e-05 23.7 0.1 6.1e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain StbA PF06406.6 AIC16663.1 - 0.0062 15.5 0.1 0.017 14.0 0.1 1.7 2 0 0 2 2 2 1 StbA protein Mago_nashi PF02792.9 AIC16663.1 - 0.12 12.0 0.9 0.31 10.7 0.7 1.6 2 0 0 2 2 2 0 Mago nashi protein DNA_pack_N PF02500.10 AIC16663.1 - 0.36 10.3 4.1 0.6 9.5 2.8 1.2 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus DUF4363 PF14276.1 AIC16663.1 - 4.4 7.0 6.9 8 6.1 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) Hydantoinase_A PF01968.13 AIC16663.1 - 4.9 6.1 11.7 0.53 9.3 0.5 3.7 3 1 0 3 3 3 0 Hydantoinase/oxoprolinase CTDII PF01556.13 AIC16664.1 - 1e-30 105.4 0.5 1.1e-22 79.6 0.1 3.2 3 0 0 3 3 3 3 DnaJ C terminal domain DnaJ PF00226.26 AIC16664.1 - 5.7e-29 99.6 3.8 9.5e-29 98.9 2.7 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.14 AIC16664.1 - 3.2e-13 49.5 14.5 5.2e-13 48.8 10.1 1.3 1 0 0 1 1 1 1 DnaJ central domain HSP20 PF00011.16 AIC16665.1 - 3.2e-09 36.5 0.6 2.9e-07 30.2 0.4 2.3 1 1 0 1 1 1 1 Hsp20/alpha crystallin family CS PF04969.11 AIC16665.1 - 3.7e-05 24.2 0.0 5.4e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 CS domain GvpH PF05455.6 AIC16665.1 - 0.00011 21.9 0.2 0.00016 21.3 0.1 1.3 1 1 0 1 1 1 1 GvpH Cas_Cas1 PF01867.11 AIC16666.1 - 4.1e-08 32.6 0.0 5.1e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas1 GNT-I PF03071.10 AIC16669.1 - 0.08 11.4 0.0 0.08 11.4 0.0 1.0 1 0 0 1 1 1 0 GNT-I family Ribosomal_S15 PF00312.17 AIC16669.1 - 0.099 12.4 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein S15 Bac_luciferase PF00296.15 AIC16670.1 - 2.2e-49 168.2 0.2 3e-49 167.7 0.1 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase AmoC PF04896.7 AIC16671.1 - 1e-13 50.9 4.2 1.3e-13 50.5 2.9 1.0 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C YrhK PF14145.1 AIC16671.1 - 0.062 12.9 0.6 0.15 11.7 0.4 1.6 1 0 0 1 1 1 0 YrhK-like protein Abhydrolase_9_N PF15420.1 AIC16671.1 - 0.15 11.8 1.6 0.39 10.4 0.1 2.0 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Zn_peptidase PF04228.8 AIC16672.1 - 1.3e-113 379.0 0.0 1.5e-113 378.8 0.0 1.0 1 0 0 1 1 1 1 Putative neutral zinc metallopeptidase DUF3152 PF11350.3 AIC16672.1 - 0.018 14.5 0.0 0.041 13.3 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3152) Peptidase_M48 PF01435.13 AIC16672.1 - 0.41 10.1 2.5 3.5 7.1 1.2 2.1 1 1 0 2 2 2 0 Peptidase family M48 zf-C2H2_4 PF13894.1 AIC16676.1 - 5.1e-05 23.3 0.5 8.2e-05 22.6 0.3 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC16676.1 - 0.0086 16.3 0.6 0.015 15.6 0.4 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-Sec23_Sec24 PF04810.10 AIC16676.1 - 0.035 13.6 0.2 0.44 10.1 0.0 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zf-met PF12874.2 AIC16676.1 - 0.09 13.0 0.2 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type SRP40_C PF05022.7 AIC16676.1 - 0.13 12.7 1.2 0.22 12.0 0.9 1.4 1 1 0 1 1 1 0 SRP40, C-terminal domain Baculo_IE-1 PF05290.6 AIC16676.1 - 0.15 11.7 0.4 0.23 11.1 0.1 1.4 1 1 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) DUF1272 PF06906.6 AIC16678.1 - 0.01 15.6 2.6 0.014 15.1 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) DUF2296 PF10058.4 AIC16678.1 - 0.11 12.2 2.5 0.24 11.1 1.7 1.6 1 1 0 1 1 1 0 Predicted integral membrane metal-binding protein (DUF2296) zf-CHY PF05495.7 AIC16678.1 - 4.8 7.4 7.4 0.87 9.7 1.8 1.9 1 1 1 2 2 2 0 CHY zinc finger ComA PF02679.10 AIC16679.1 - 1.8e-48 164.6 0.2 4.2e-48 163.5 0.0 1.5 2 0 0 2 2 2 1 (2R)-phospho-3-sulfolactate synthase (ComA) TrmB PF01978.14 AIC16679.1 - 0.00032 20.3 0.0 0.00068 19.2 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_36 PF13730.1 AIC16679.1 - 0.00047 20.2 0.0 0.00095 19.2 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.2 AIC16679.1 - 0.00072 19.1 0.0 0.0015 18.1 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_43 PF09904.4 AIC16679.1 - 0.0032 17.2 0.1 0.017 14.9 0.0 2.2 3 0 0 3 3 3 1 Winged helix-turn helix HTH_11 PF08279.7 AIC16679.1 - 0.022 14.3 0.0 0.056 13.1 0.0 1.7 1 0 0 1 1 1 0 HTH domain RNA_pol_Rpc34 PF05158.7 AIC16679.1 - 0.085 12.0 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit NMT1_2 PF13379.1 AIC16680.1 - 3.9e-30 105.0 0.0 5.3e-30 104.6 0.0 1.1 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.6 AIC16680.1 - 5.8e-16 58.7 0.1 8.5e-16 58.2 0.1 1.3 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.2 AIC16680.1 - 3.9e-11 42.7 0.0 7.6e-11 41.8 0.0 1.4 1 1 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.15 AIC16680.1 - 2e-06 27.2 0.0 0.0012 18.1 0.0 2.4 1 1 1 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 ABC_tran PF00005.22 AIC16681.1 - 8.5e-32 110.3 0.0 1.6e-31 109.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC16681.1 - 2.2e-10 41.0 0.2 4.8e-05 23.4 0.0 2.2 1 1 0 2 2 2 2 AAA domain SMC_N PF02463.14 AIC16681.1 - 3.3e-05 23.2 0.2 0.09 11.9 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 AIC16681.1 - 3.6e-05 22.9 0.0 0.03 13.3 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain ABC_ATPase PF09818.4 AIC16681.1 - 4.9e-05 22.0 0.1 0.0092 14.6 0.0 2.2 2 0 0 2 2 2 2 Predicted ATPase of the ABC class DUF258 PF03193.11 AIC16681.1 - 0.00028 20.0 0.0 0.00052 19.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_16 PF13191.1 AIC16681.1 - 0.00035 20.6 0.7 0.00071 19.6 0.5 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA PF00004.24 AIC16681.1 - 0.00048 20.3 0.3 0.01 16.0 0.2 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.1 AIC16681.1 - 0.00058 19.3 0.1 0.0027 17.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.1 AIC16681.1 - 0.001 18.5 0.1 0.0022 17.4 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.1 AIC16681.1 - 0.0037 17.4 0.2 0.043 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 AIC16681.1 - 0.0059 16.3 0.0 0.015 15.0 0.0 1.6 1 0 0 1 1 1 1 Archaeal ATPase NB-ARC PF00931.17 AIC16681.1 - 0.0065 15.3 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain Rad17 PF03215.10 AIC16681.1 - 0.022 13.4 0.0 0.032 12.9 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_17 PF13207.1 AIC16681.1 - 0.022 15.6 1.5 0.042 14.6 0.1 2.1 2 1 0 2 2 2 0 AAA domain Miro PF08477.8 AIC16681.1 - 0.037 14.5 0.1 0.11 12.9 0.0 1.9 2 0 0 2 2 1 0 Miro-like protein IstB_IS21 PF01695.12 AIC16681.1 - 0.053 12.9 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_33 PF13671.1 AIC16681.1 - 0.055 13.3 0.2 0.29 10.9 0.1 2.1 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 AIC16681.1 - 0.056 13.2 0.0 1.6 8.5 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain AAA_28 PF13521.1 AIC16681.1 - 0.062 13.2 0.0 0.33 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.11 AIC16681.1 - 0.071 12.3 0.0 0.22 10.7 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_14 PF13173.1 AIC16681.1 - 0.074 12.9 0.0 0.18 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.1 AIC16681.1 - 0.1 12.9 1.2 0.34 11.2 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.1 AIC16681.1 - 0.11 12.8 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.7 AIC16681.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain MobB PF03205.9 AIC16681.1 - 0.11 12.1 0.7 0.29 10.8 0.1 1.9 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B DUF3604 PF12228.3 AIC16681.1 - 0.14 10.2 0.0 0.21 9.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3604) SbcCD_C PF13558.1 AIC16681.1 - 0.16 11.9 0.2 0.93 9.4 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit BPD_transp_1 PF00528.17 AIC16682.1 - 1.8e-15 56.9 17.0 1.8e-15 56.9 11.8 2.1 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DLH PF01738.13 AIC16683.1 - 2.3e-56 190.5 0.0 2.9e-56 190.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.2 AIC16683.1 - 1.4e-15 57.3 0.8 1.9e-15 56.8 0.1 1.5 2 0 0 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.16 AIC16683.1 - 7.4e-11 41.6 0.4 6.1e-06 25.6 0.0 2.8 2 1 1 3 3 3 2 Prolyl oligopeptidase family BAAT_C PF08840.6 AIC16683.1 - 2.5e-10 40.4 0.7 0.0022 17.7 0.0 3.3 2 1 1 3 3 3 3 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_6 PF12697.2 AIC16683.1 - 2.1e-07 31.0 0.0 0.013 15.4 0.0 2.2 1 1 1 2 2 2 2 Alpha/beta hydrolase family Chlorophyllase2 PF12740.2 AIC16683.1 - 4.9e-05 22.3 0.0 7.7e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Chlorophyllase enzyme Chlorophyllase PF07224.6 AIC16683.1 - 6.4e-05 21.9 0.0 8e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Abhydrolase_2 PF02230.11 AIC16683.1 - 0.0035 16.8 0.0 0.0056 16.1 0.0 1.4 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF3185 PF11381.3 AIC16683.1 - 0.023 14.4 1.1 0.057 13.1 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3185) Copper-bind PF00127.15 AIC16684.1 - 1.2e-09 38.3 0.3 2.8e-09 37.1 0.2 1.7 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC16684.1 - 0.077 12.9 0.3 0.21 11.4 0.2 1.8 1 1 0 1 1 1 0 Cupredoxin-like domain RNA_bind_2 PF10133.4 AIC16684.1 - 0.11 12.6 0.2 0.24 11.4 0.1 1.6 1 0 0 1 1 1 0 Predicted RNA-binding protein BAR_2 PF10455.4 AIC16687.1 - 0.07 12.0 0.0 0.072 11.9 0.0 1.0 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking PfkB PF00294.19 AIC16688.1 - 3.8e-17 62.3 0.4 5e-17 61.9 0.3 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Pyr_redox PF00070.22 AIC16688.1 - 0.018 15.4 0.0 0.23 11.9 0.0 2.3 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase OTCace PF00185.19 AIC16688.1 - 0.15 11.9 0.0 1.5 8.7 0.0 2.4 3 0 0 3 3 3 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Cpn60_TCP1 PF00118.19 AIC16689.1 - 6.1e-172 572.6 13.7 6.9e-172 572.4 9.5 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ustilago_mating PF05722.7 AIC16689.1 - 0.019 14.2 0.2 0.14 11.3 0.0 2.1 2 0 0 2 2 2 0 Ustilago B locus mating-type protein 4HBT PF03061.17 AIC16690.1 - 0.029 14.5 0.0 0.078 13.1 0.0 1.7 2 0 0 2 2 2 0 Thioesterase superfamily zf-C2H2_6 PF13912.1 AIC16691.1 - 0.00016 21.4 3.3 0.038 13.9 0.4 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC16691.1 - 0.0007 19.7 11.6 0.011 15.9 1.7 2.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type XPA_N PF01286.13 AIC16691.1 - 0.0029 17.2 4.3 0.53 10.0 0.3 2.2 2 0 0 2 2 2 2 XPA protein N-terminal zinc_ribbon_4 PF13717.1 AIC16691.1 - 0.0036 16.9 1.7 0.87 9.3 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC16691.1 - 0.0043 16.5 2.0 0.91 9.1 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zf-DNA_Pol PF08996.5 AIC16691.1 - 0.0098 15.2 0.5 0.01 15.1 0.3 1.1 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger DZR PF12773.2 AIC16691.1 - 0.032 14.0 0.3 0.051 13.4 0.2 1.3 1 0 0 1 1 1 0 Double zinc ribbon Mut7-C PF01927.11 AIC16691.1 - 0.04 13.9 0.6 0.05 13.5 0.4 1.2 1 0 0 1 1 1 0 Mut7-C RNAse domain zf-C2H2_4 PF13894.1 AIC16691.1 - 0.048 13.9 14.8 0.41 11.1 0.3 2.9 2 1 1 3 3 3 0 C2H2-type zinc finger Lar_restr_allev PF14354.1 AIC16691.1 - 0.099 12.9 1.3 0.76 10.1 0.9 1.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-trcl PF13451.1 AIC16691.1 - 0.11 12.1 2.5 1.5 8.4 0.1 2.3 2 0 0 2 2 2 0 Probable zinc-binding domain DNA_RNApol_7kD PF03604.8 AIC16691.1 - 0.21 11.0 1.6 4.3 6.8 0.1 2.3 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit FUR PF01475.14 AIC16691.1 - 0.32 10.9 8.9 0.39 10.6 6.2 1.3 1 1 0 1 1 1 0 Ferric uptake regulator family c-SKI_SMAD_bind PF08782.5 AIC16691.1 - 0.36 10.9 7.1 1.7 8.8 0.5 2.1 1 1 1 2 2 2 0 c-SKI Smad4 binding domain FYVE PF01363.16 AIC16691.1 - 2.2 8.2 10.1 5.8 6.8 7.0 1.7 1 1 0 1 1 1 0 FYVE zinc finger Zn-ribbon_8 PF09723.5 AIC16691.1 - 2.7 7.9 6.2 17 5.4 0.4 2.4 1 1 1 2 2 2 0 Zinc ribbon domain zf-LYAR PF08790.6 AIC16691.1 - 3.2 7.5 11.1 8.1 6.2 0.3 2.6 2 1 0 2 2 2 0 LYAR-type C2HC zinc finger zinc_ribbon_6 PF14599.1 AIC16691.1 - 4.3 7.2 6.4 3 7.7 0.5 2.2 1 1 1 2 2 2 0 Zinc-ribbon YhfH PF14149.1 AIC16691.1 - 4.4 7.1 6.0 6.3 6.6 0.1 2.4 2 0 0 2 2 2 0 YhfH-like protein Ribosomal_L44 PF00935.14 AIC16692.1 - 1.2e-24 86.1 10.5 1.2e-24 86.1 7.3 1.4 2 0 0 2 2 1 1 Ribosomal protein L44 NOB1_Zn_bind PF08772.6 AIC16692.1 - 0.00027 20.7 3.5 0.0017 18.1 0.1 2.2 2 0 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like Ribosomal_L33 PF00471.15 AIC16692.1 - 0.015 15.5 1.0 0.015 15.5 0.7 2.3 2 0 0 2 2 2 0 Ribosomal protein L33 zf-ISL3 PF14690.1 AIC16692.1 - 0.061 13.3 4.5 2 8.5 0.2 2.3 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Elf1 PF05129.8 AIC16692.1 - 0.071 12.8 3.1 1.7 8.4 0.4 2.2 2 0 0 2 2 2 0 Transcription elongation factor Elf1 like Nudix_N_2 PF14803.1 AIC16692.1 - 0.077 12.7 2.7 4.2 7.1 0.1 2.3 2 0 0 2 2 2 0 Nudix N-terminal GFA PF04828.9 AIC16692.1 - 0.098 12.6 5.0 0.76 9.7 0.2 2.1 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Zn-ribbon_8 PF09723.5 AIC16692.1 - 0.11 12.4 1.6 4.4 7.3 0.2 2.3 2 0 0 2 2 2 0 Zinc ribbon domain C1_4 PF07975.7 AIC16692.1 - 0.13 12.3 2.9 0.43 10.6 0.2 2.1 2 0 0 2 2 2 0 TFIIH C1-like domain Ribosomal_L37ae PF01780.14 AIC16692.1 - 0.13 12.1 8.0 2.4 8.1 1.6 2.1 1 1 1 2 2 2 0 Ribosomal L37ae protein family Rpr2 PF04032.11 AIC16692.1 - 0.14 12.0 5.0 0.22 11.3 3.4 1.4 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-FPG_IleRS PF06827.9 AIC16692.1 - 0.17 11.5 3.3 1 9.0 0.1 2.4 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS DZR PF12773.2 AIC16692.1 - 0.21 11.4 5.7 1 9.2 4.0 1.9 1 1 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.2 AIC16692.1 - 0.29 10.9 2.7 7.9 6.3 0.3 2.2 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-DNL PF05180.7 AIC16692.1 - 0.33 10.6 3.8 0.77 9.5 0.6 2.2 2 0 0 2 2 2 0 DNL zinc finger Zn_Tnp_IS1 PF03811.8 AIC16692.1 - 0.64 9.5 4.8 5.7 6.5 0.2 2.9 2 1 1 3 3 3 0 InsA N-terminal domain zf-Dof PF02701.10 AIC16692.1 - 0.66 9.9 4.6 1.9 8.4 0.2 2.3 2 1 0 2 2 2 0 Dof domain, zinc finger TFIIS_C PF01096.13 AIC16692.1 - 0.84 9.3 6.0 6 6.5 1.0 2.2 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-AN1 PF01428.11 AIC16692.1 - 1.3 8.9 4.8 1.1 9.2 0.6 2.1 2 0 0 2 2 2 0 AN1-like Zinc finger zf-HIT PF04438.11 AIC16692.1 - 4.6 6.9 8.3 9.2 6.0 1.1 2.2 2 0 0 2 2 2 0 HIT zinc finger Ribosomal_S27e PF01667.12 AIC16693.1 - 2.4e-16 59.0 0.9 2.6e-16 58.8 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 DZR PF12773.2 AIC16693.1 - 0.00056 19.6 0.5 0.0007 19.3 0.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon TF_Zn_Ribbon PF08271.7 AIC16693.1 - 0.0011 18.2 0.1 0.0015 17.8 0.1 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.6 AIC16693.1 - 0.0011 18.6 0.8 0.0013 18.3 0.6 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain DNA_RNApol_7kD PF03604.8 AIC16693.1 - 0.0036 16.7 0.7 0.39 10.2 0.1 2.2 2 0 0 2 2 2 1 DNA directed RNA polymerase, 7 kDa subunit zf-ribbon_3 PF13248.1 AIC16693.1 - 0.015 14.4 2.2 0.044 12.9 1.5 1.7 1 1 1 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.1 AIC16693.1 - 0.033 13.6 1.6 1.2 8.6 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF4206 PF13901.1 AIC16693.1 - 0.034 13.6 0.4 0.037 13.5 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) zinc_ribbon_4 PF13717.1 AIC16693.1 - 0.035 13.7 4.4 1.5 8.6 3.3 2.2 1 1 1 2 2 2 0 zinc-ribbon domain Prok-RING_1 PF14446.1 AIC16693.1 - 0.036 13.7 0.9 6.9 6.4 0.1 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 zinc_ribbon_5 PF13719.1 AIC16693.1 - 0.036 13.6 4.2 1 8.9 3.0 2.2 1 1 1 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.5 AIC16693.1 - 0.037 13.9 2.7 0.066 13.1 1.9 1.4 1 1 0 1 1 1 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.2 AIC16693.1 - 0.049 13.4 0.9 0.061 13.1 0.7 1.2 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Lar_restr_allev PF14354.1 AIC16693.1 - 0.05 13.9 1.8 0.16 12.2 1.3 1.8 1 1 0 1 1 1 0 Restriction alleviation protein Lar HypA PF01155.14 AIC16693.1 - 0.064 12.9 0.5 0.078 12.6 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family Stc1 PF12898.2 AIC16693.1 - 0.079 13.0 2.2 0.1 12.6 1.5 1.3 1 1 0 1 1 1 0 Stc1 domain zf-C4_Topoisom PF01396.14 AIC16693.1 - 0.095 12.2 0.4 5 6.7 0.0 2.2 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Zn_Tnp_IS91 PF14319.1 AIC16693.1 - 0.11 12.0 0.6 0.12 11.8 0.4 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain A2L_zn_ribbon PF08792.5 AIC16693.1 - 0.11 11.9 0.9 5.3 6.6 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain zinc_ribbon_6 PF14599.1 AIC16693.1 - 0.12 12.2 0.8 0.2 11.4 0.5 1.4 1 1 0 1 1 1 0 Zinc-ribbon TFIIS_C PF01096.13 AIC16693.1 - 0.12 12.0 2.8 5.3 6.7 1.9 2.1 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS) Rpr2 PF04032.11 AIC16693.1 - 0.12 12.2 0.3 3.4 7.5 0.0 2.0 2 0 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-C2HC_2 PF13913.1 AIC16693.1 - 0.2 11.3 3.6 8.9 6.1 0.0 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Elf1 PF05129.8 AIC16693.1 - 0.24 11.1 2.5 0.93 9.2 1.7 1.8 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like Yippee-Mis18 PF03226.9 AIC16693.1 - 0.27 11.2 2.3 1.2 9.2 0.1 2.0 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Mu-like_Com PF10122.4 AIC16693.1 - 0.31 10.1 1.6 0.92 8.6 1.1 1.8 1 1 0 1 1 1 0 Mu-like prophage protein Com CpXC PF14353.1 AIC16693.1 - 0.4 10.6 1.9 4.7 7.1 0.0 2.0 1 1 1 2 2 2 0 CpXC protein Ogr_Delta PF04606.7 AIC16693.1 - 0.43 10.2 2.8 0.63 9.7 0.1 2.2 2 1 0 2 2 2 0 Ogr/Delta-like zinc finger RRN7 PF11781.3 AIC16693.1 - 0.44 10.0 3.0 7 6.2 0.1 2.2 1 1 1 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 zf-C2H2_3 PF13878.1 AIC16693.1 - 0.57 9.7 2.7 11 5.6 0.1 2.1 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO NTP_transf_3 PF12804.2 AIC16694.1 - 1.5e-17 64.1 0.1 1.8e-17 63.8 0.1 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.14 AIC16694.1 - 2.5e-09 36.9 0.1 3.7e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.14 AIC16694.1 - 0.00033 20.3 0.0 0.00089 18.9 0.0 1.5 1 1 0 1 1 1 1 Cytidylyltransferase CofC PF01983.11 AIC16694.1 - 0.0039 16.1 0.2 0.0071 15.3 0.0 1.5 2 0 0 2 2 2 1 Guanylyl transferase CofC like GFO_IDH_MocA PF01408.17 AIC16694.1 - 0.0092 16.4 0.0 0.027 14.9 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DUF2064 PF09837.4 AIC16694.1 - 0.095 12.3 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) CobS PF02654.10 AIC16695.1 - 2e-48 165.0 15.2 2.2e-48 164.8 10.5 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase CobD_Cbib PF03186.8 AIC16696.1 - 3.4e-94 315.2 3.4 4.2e-94 314.9 2.4 1.1 1 0 0 1 1 1 1 CobD/Cbib protein DUF2374 PF09574.5 AIC16696.1 - 5.5 6.6 9.1 1.3 8.7 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) CbiA PF01656.18 AIC16697.1 - 1.3e-27 96.4 0.0 1.6e-27 96.1 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.1 AIC16697.1 - 2.5e-16 59.8 0.0 6.2e-16 58.6 0.0 1.6 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 AIC16697.1 - 9.9e-05 22.0 0.0 0.0022 17.7 0.0 2.2 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 AIC16697.1 - 0.02 14.3 0.0 0.027 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain AAA_30 PF13604.1 AIC16697.1 - 0.08 12.5 0.3 0.25 10.9 0.2 2.1 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.22 AIC16697.1 - 0.11 12.8 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 ABC transporter VirC1 PF07015.6 AIC16697.1 - 0.13 11.2 0.0 0.29 10.1 0.0 1.6 1 0 0 1 1 1 0 VirC1 protein Aminotran_1_2 PF00155.16 AIC16698.1 - 7.4e-46 156.7 0.0 9.5e-46 156.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II NAAA-beta PF15508.1 AIC16698.1 - 0.048 14.0 0.0 0.1 12.9 0.0 1.6 1 0 0 1 1 1 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Semialdhyde_dhC PF02774.13 AIC16699.1 - 1.1e-37 129.6 0.0 1.7e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.19 AIC16699.1 - 1.8e-26 92.7 0.0 3.6e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Gp_dh_C PF02800.15 AIC16699.1 - 5.9e-05 22.5 0.2 0.026 13.9 0.0 2.7 3 0 0 3 3 3 2 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DapB_N PF01113.15 AIC16699.1 - 0.00054 19.8 0.0 0.0013 18.6 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus GFO_IDH_MocA PF01408.17 AIC16699.1 - 0.044 14.2 0.0 0.076 13.5 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold RRM_3 PF08777.6 AIC16699.1 - 0.069 13.0 0.1 0.43 10.4 0.0 2.2 2 0 0 2 2 2 0 RNA binding motif Ldh_1_N PF00056.18 AIC16699.1 - 0.11 12.3 0.1 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain CarboxypepD_reg PF13620.1 AIC16700.1 - 0.0057 16.6 0.2 0.0057 16.6 0.1 1.9 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain AlcCBM31 PF11606.3 AIC16700.1 - 0.22 11.5 0.9 24 4.9 0.0 2.7 1 1 1 2 2 2 0 Family 31 carbohydrate binding protein NfeD PF01957.13 AIC16700.1 - 0.89 9.6 4.5 0.61 10.2 1.4 2.0 1 1 0 1 1 1 0 NfeD-like C-terminal, partner-binding AsnC_trans_reg PF01037.16 AIC16701.1 - 4e-15 55.2 0.1 6.7e-15 54.5 0.1 1.4 1 0 0 1 1 1 1 AsnC family HTH_24 PF13412.1 AIC16701.1 - 8.3e-14 50.7 0.8 2e-13 49.4 0.6 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC16701.1 - 2e-09 36.8 0.0 3.9e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain MarR PF01047.17 AIC16701.1 - 1.9e-06 27.4 0.1 5.2e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC16701.1 - 8.5e-06 25.3 0.9 1.4e-05 24.6 0.1 1.8 2 0 0 2 2 1 1 Sugar-specific transcriptional regulator TrmB MotA_activ PF09114.5 AIC16701.1 - 6.2e-05 22.6 1.0 0.0001 22.0 0.6 1.5 1 1 0 1 1 1 1 Transcription factor MotA, activation domain B-block_TFIIIC PF04182.7 AIC16701.1 - 8.6e-05 22.3 0.8 0.00013 21.7 0.6 1.4 1 1 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_11 PF08279.7 AIC16701.1 - 0.00067 19.2 0.4 0.0015 18.0 0.3 1.6 1 0 0 1 1 1 1 HTH domain HTH_27 PF13463.1 AIC16701.1 - 0.0016 18.7 0.1 0.0063 16.8 0.0 1.9 2 1 1 3 3 3 1 Winged helix DNA-binding domain Ribosomal_S25 PF03297.10 AIC16701.1 - 0.002 18.1 2.5 0.0037 17.2 0.6 1.9 2 0 0 2 2 2 1 S25 ribosomal protein MarR_2 PF12802.2 AIC16701.1 - 0.0027 17.3 0.0 0.0054 16.3 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.2 AIC16701.1 - 0.0042 16.8 0.0 0.015 15.0 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain Rrf2 PF02082.15 AIC16701.1 - 0.0048 16.9 0.1 0.01 15.9 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_34 PF13601.1 AIC16701.1 - 0.0079 16.2 0.2 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_5 PF01022.15 AIC16701.1 - 0.01 15.5 0.2 0.021 14.4 0.2 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Sulfolobus_pRN PF05584.6 AIC16701.1 - 0.015 15.2 0.2 0.043 13.7 0.1 1.7 2 0 0 2 2 2 0 Sulfolobus plasmid regulatory protein HTH_45 PF14947.1 AIC16701.1 - 0.025 14.3 0.4 0.069 12.9 0.1 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix Linocin_M18 PF04454.7 AIC16701.1 - 0.038 12.9 0.2 0.05 12.4 0.1 1.1 1 0 0 1 1 1 0 Encapsulating protein for peroxidase Mga PF05043.8 AIC16701.1 - 0.04 14.1 0.1 0.092 13.0 0.1 1.5 1 0 0 1 1 1 0 Mga helix-turn-helix domain FeoC PF09012.5 AIC16701.1 - 0.044 13.4 0.2 0.12 12.1 0.0 1.7 2 0 0 2 2 2 0 FeoC like transcriptional regulator Fe_dep_repress PF01325.14 AIC16701.1 - 0.12 12.3 0.2 0.26 11.2 0.1 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain UbiA PF01040.13 AIC16702.1 - 2.3e-34 118.7 23.5 3.1e-34 118.3 16.3 1.0 1 0 0 1 1 1 1 UbiA prenyltransferase family Abhydrolase_2 PF02230.11 AIC16702.1 - 0.063 12.7 0.1 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase SecE PF00584.15 AIC16702.1 - 0.25 10.9 7.2 0.85 9.2 0.2 3.1 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex EMG1 PF03587.9 AIC16703.1 - 8.6e-44 149.2 0.0 9.6e-44 149.0 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Rpr2 PF04032.11 AIC16704.1 - 4.7e-17 61.6 0.3 5.5e-17 61.4 0.2 1.1 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4636 PF15468.1 AIC16704.1 - 0.0014 18.1 0.1 0.0016 17.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4636) PapD-like PF14874.1 AIC16704.1 - 0.025 14.5 0.1 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 Flagellar-associated PapD-like zf-Sec23_Sec24 PF04810.10 AIC16704.1 - 0.083 12.4 0.8 4.6 6.8 0.1 2.2 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger zinc_ribbon_4 PF13717.1 AIC16704.1 - 0.086 12.5 0.9 7.2 6.3 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC16704.1 - 0.14 11.7 0.7 10 5.7 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF572 PF04502.8 AIC16704.1 - 0.16 11.1 0.9 0.18 10.9 0.6 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Cys_rich_KTR PF14205.1 AIC16704.1 - 0.25 10.8 2.5 1.9 8.0 0.1 2.3 2 0 0 2 2 2 0 Cysteine-rich KTR Ribosomal_S19e PF01090.14 AIC16705.1 - 1.1e-54 183.6 0.1 1.3e-54 183.4 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e HTH_12 PF08461.5 AIC16705.1 - 0.1 12.3 0.0 0.21 11.3 0.0 1.6 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain MarR PF01047.17 AIC16705.1 - 0.12 12.1 0.0 10 5.9 0.0 2.6 2 0 0 2 2 2 0 MarR family dsDNA_bind PF01984.15 AIC16706.1 - 2.7e-25 88.3 1.4 3.2e-25 88.2 1.0 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Tom5 PF10642.4 AIC16706.1 - 0.0017 17.9 0.4 0.0078 15.8 0.1 2.0 2 0 0 2 2 2 1 Mitochondrial import receptor subunit or translocase ADH_zinc_N PF00107.21 AIC16707.1 - 8e-31 106.2 0.1 1.5e-30 105.3 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.7 AIC16707.1 - 8.9e-28 96.2 0.0 1.9e-27 95.1 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.1 AIC16707.1 - 1.9e-15 57.8 0.0 4.4e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase C1_2 PF03107.11 AIC16707.1 - 0.26 11.4 2.7 0.43 10.7 1.8 1.4 1 0 0 1 1 1 0 C1 domain HpcH_HpaI PF03328.9 AIC16708.1 - 2.6e-48 163.8 2.5 3.4e-48 163.4 1.7 1.2 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.1 AIC16708.1 - 1.5e-17 63.4 0.3 2e-08 33.4 0.0 2.1 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold RRM_2 PF04059.7 AIC16708.1 - 0.033 14.1 0.0 1 9.4 0.0 2.2 1 1 1 2 2 2 0 RNA recognition motif 2 SBF PF01758.11 AIC16709.1 - 3.9e-14 52.4 16.4 3.9e-14 52.4 11.4 1.7 2 0 0 2 2 2 1 Sodium Bile acid symporter family UNC-93 PF05978.11 AIC16709.1 - 0.011 15.2 0.2 0.011 15.2 0.1 2.6 2 2 0 2 2 2 0 Ion channel regulatory protein UNC-93 Mem_trans PF03547.13 AIC16709.1 - 0.08 11.2 15.1 0.061 11.6 0.9 2.3 1 1 0 2 2 2 0 Membrane transport protein Dispanin PF04505.7 AIC16709.1 - 0.23 10.9 4.1 4.3 6.9 0.2 3.0 3 0 0 3 3 3 0 Interferon-induced transmembrane protein Peptidase_M3 PF01432.15 AIC16710.1 - 4.5e-46 157.8 0.0 6.6e-46 157.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.5 AIC16710.1 - 2e-12 46.9 0.6 1.1e-10 41.3 0.1 2.7 2 0 0 2 2 2 1 Oligopeptidase F Peptidase_MA_2 PF13485.1 AIC16710.1 - 0.0023 17.9 0.1 0.0074 16.3 0.0 1.9 2 0 0 2 2 2 1 Peptidase MA superfamily B56 PF01603.15 AIC16710.1 - 0.13 10.7 0.0 0.23 10.0 0.0 1.3 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) Big_3_4 PF13754.1 AIC16711.1 - 0.0024 18.1 0.0 0.0044 17.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 3) CAP PF00188.21 AIC16711.1 - 0.005 17.3 0.1 0.012 16.0 0.1 1.8 1 1 0 1 1 1 1 Cysteine-rich secretory protein family Phospholip_A2_2 PF05826.7 AIC16711.1 - 0.018 14.9 0.0 0.028 14.3 0.0 1.3 1 0 0 1 1 1 0 Phospholipase A2 DUF167 PF02594.11 AIC16712.1 - 3.9e-15 55.5 0.1 4.7e-15 55.2 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 DNA_alkylation PF08713.6 AIC16713.1 - 3.5e-69 232.5 0.2 4e-69 232.3 0.1 1.0 1 0 0 1 1 1 1 DNA alkylation repair enzyme B12-binding_2 PF02607.12 AIC16713.1 - 0.0053 16.7 0.1 0.015 15.3 0.0 1.8 2 0 0 2 2 2 1 B12 binding domain U-box PF04564.10 AIC16713.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 U-box domain RST PF12174.3 AIC16714.1 - 0.22 11.3 1.3 0.42 10.4 0.9 1.6 1 1 0 1 1 1 0 RCD1-SRO-TAF4 (RST) plant domain Glyco_tranf_2_3 PF13641.1 AIC16715.1 - 3.8e-11 43.2 0.1 8.2e-11 42.1 0.0 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.1 AIC16715.1 - 8.9e-09 35.3 0.0 1.8e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Fringe PF02434.11 AIC16715.1 - 5.5e-05 22.4 0.1 8.3e-05 21.9 0.0 1.2 1 0 0 1 1 1 1 Fringe-like PBP_like_2 PF12849.2 AIC16717.1 - 7.1e-24 84.7 6.0 1e-23 84.2 4.2 1.2 1 0 0 1 1 1 1 PBP superfamily domain Glycos_transf_1 PF00534.15 AIC16718.1 - 5.4e-20 71.4 0.0 8.5e-20 70.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.1 AIC16718.1 - 9.8e-07 28.9 0.0 3e-06 27.4 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 DUF563 PF04577.9 AIC16718.1 - 0.04 13.8 0.0 0.14 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF563) Dodecin PF07311.7 AIC16719.1 - 1e-23 83.1 1.1 1.1e-23 83.0 0.8 1.0 1 0 0 1 1 1 1 Dodecin DUF608 PF04685.8 AIC16720.1 - 9.6e-09 34.4 0.1 1.5e-08 33.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function, DUF608 GDE_C PF06202.9 AIC16720.1 - 6.8e-05 21.7 0.1 0.22 10.1 0.0 2.4 2 0 0 2 2 2 2 Amylo-alpha-1,6-glucosidase GlcNAc_2-epim PF07221.6 AIC16720.1 - 0.0016 17.5 0.1 0.0099 14.9 0.0 1.9 2 0 0 2 2 2 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Bac_rhamnosid PF05592.6 AIC16720.1 - 0.064 11.4 0.0 0.091 10.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase DUF3498 PF12004.3 AIC16720.1 - 0.19 10.7 0.0 0.29 10.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) FMN_red PF03358.10 AIC16721.1 - 0.022 14.2 0.1 0.025 14.1 0.0 1.1 1 0 0 1 1 1 0 NADPH-dependent FMN reductase FMN_red PF03358.10 AIC16722.1 - 0.00091 18.7 0.1 0.0015 18.0 0.0 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase YqbF PF14553.1 AIC16723.1 - 0.42 10.3 2.0 0.49 10.0 1.4 1.3 1 0 0 1 1 1 0 YqbF, hypothetical protein domain Rubrerythrin PF02915.12 AIC16727.1 - 7e-05 23.1 0.3 8.2e-05 22.9 0.2 1.3 1 1 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.1 AIC16727.1 - 0.0064 16.4 0.1 0.0074 16.2 0.1 1.3 1 1 0 1 1 1 1 Ferritin-like domain Ferritin PF00210.19 AIC16727.1 - 0.02 14.6 1.0 0.023 14.4 0.7 1.2 1 0 0 1 1 1 0 Ferritin-like domain Mer2 PF09074.5 AIC16727.1 - 0.055 13.3 0.6 0.15 11.9 0.1 1.7 1 1 1 2 2 2 0 Mer2 ASFV_J13L PF05568.6 AIC16728.1 - 0.12 11.9 0.2 0.13 11.8 0.1 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein ATP-grasp_5 PF13549.1 AIC16729.1 - 1.8e-83 279.1 0.2 3.5e-83 278.2 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.1 AIC16729.1 - 3.3e-54 182.2 1.5 3.3e-54 182.2 1.0 1.9 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.1 AIC16729.1 - 3.1e-23 82.1 0.3 3.2e-21 75.6 0.0 3.5 3 0 0 3 3 3 1 CoA binding domain CoA_binding PF02629.14 AIC16729.1 - 1.7e-13 50.9 3.2 1.9e-13 50.7 0.5 2.4 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.5 AIC16729.1 - 1.2e-05 24.7 0.3 3e-05 23.4 0.1 1.9 2 0 0 2 2 2 1 ATP-grasp domain ATP-grasp_4 PF13535.1 AIC16729.1 - 1.4e-05 24.9 0.0 3e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.12 AIC16729.1 - 0.0028 16.9 0.1 0.0056 15.9 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain YIEGIA PF14045.1 AIC16729.1 - 0.028 13.0 0.0 0.056 12.0 0.0 1.4 1 0 0 1 1 1 0 YIEGIA protein EFhand_Ca_insen PF08726.5 AIC16729.1 - 0.18 11.7 0.1 0.9 9.5 0.0 2.2 3 0 0 3 3 3 0 Ca2+ insensitive EF hand Glyoxalase PF00903.20 AIC16730.1 - 3e-11 43.3 0.0 1.6e-10 41.0 0.0 1.9 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.2 AIC16730.1 - 1.7e-10 41.4 0.0 3.6e-10 40.4 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.1 AIC16730.1 - 1.6e-07 31.2 0.0 4.3e-07 29.9 0.0 1.7 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 AIC16730.1 - 0.032 14.1 0.0 8 6.3 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase-like domain DZR PF12773.2 AIC16731.1 - 1.8e-08 34.0 5.0 3.1e-06 26.9 0.2 2.5 2 1 0 2 2 2 2 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC16731.1 - 1.6e-07 30.3 5.5 1.6e-07 30.3 3.8 3.0 3 0 0 3 3 3 1 zinc-ribbon domain zinc_ribbon_2 PF13240.1 AIC16731.1 - 4.7e-07 29.0 5.4 4.7e-07 29.0 3.7 2.5 3 0 0 3 3 3 1 zinc-ribbon domain PRC PF05239.11 AIC16731.1 - 0.00029 20.6 0.4 0.00045 20.0 0.3 1.3 1 0 0 1 1 1 1 PRC-barrel domain zf-RanBP PF00641.13 AIC16731.1 - 0.0024 16.9 1.0 0.0024 16.9 0.7 2.6 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others zinc-ribbons_6 PF07191.7 AIC16731.1 - 0.035 13.8 5.4 6.8 6.5 0.4 3.3 3 0 0 3 3 3 0 zinc-ribbons Zn-ribbon_8 PF09723.5 AIC16731.1 - 0.075 12.9 14.7 0.78 9.7 0.1 4.2 3 1 1 4 4 4 0 Zinc ribbon domain GCC2_GCC3 PF07699.8 AIC16731.1 - 0.23 11.0 9.5 0.25 10.9 2.2 2.9 3 0 0 3 3 3 0 GCC2 and GCC3 UPF0547 PF10571.4 AIC16731.1 - 0.35 10.6 0.0 0.35 10.6 0.0 3.4 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 zf-B_box PF00643.19 AIC16731.1 - 1.7 8.5 9.6 2.5 8.0 0.4 2.9 3 0 0 3 3 3 0 B-box zinc finger Prok-RING_1 PF14446.1 AIC16731.1 - 2.6 7.8 9.2 2.2 8.1 1.0 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 GFA PF04828.9 AIC16731.1 - 4.7 7.2 8.3 27 4.7 0.6 3.9 2 2 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme ABC2_membrane PF01061.19 AIC16732.1 - 5.5e-22 77.9 22.2 8.4e-22 77.3 15.4 1.3 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 AIC16732.1 - 6.6e-10 38.5 24.1 6.6e-10 38.5 16.7 2.0 1 1 1 2 2 2 2 ABC-2 family transporter protein ABC2_membrane_4 PF12730.2 AIC16732.1 - 1.2e-07 31.1 29.7 2.2e-07 30.2 20.6 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 AIC16732.1 - 3.2e-06 26.2 22.7 4.1e-06 25.8 15.8 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.1 AIC16732.1 - 0.0045 16.3 27.1 0.029 13.6 18.2 2.2 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.22 AIC16733.1 - 8.7e-30 103.7 0.0 1.6e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC16733.1 - 6.5e-12 46.0 0.0 1.8e-09 37.9 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.1 AIC16733.1 - 0.00082 18.5 0.0 0.027 13.5 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain AAA_23 PF13476.1 AIC16733.1 - 0.0027 18.0 0.0 0.0044 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.1 AIC16733.1 - 0.0044 16.5 0.1 0.008 15.6 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain MobB PF03205.9 AIC16733.1 - 0.0055 16.4 1.3 2.2 7.9 0.3 2.7 2 1 0 2 2 2 2 Molybdopterin guanine dinucleotide synthesis protein B SRP54 PF00448.17 AIC16733.1 - 0.013 14.9 0.1 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ACT PF01842.20 AIC16733.1 - 0.072 12.5 0.1 0.19 11.2 0.1 1.8 1 0 0 1 1 1 0 ACT domain AAA_28 PF13521.1 AIC16733.1 - 0.11 12.4 0.1 0.49 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.1 AIC16733.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_22 PF13401.1 AIC16733.1 - 0.25 11.5 1.3 5 7.2 0.6 2.7 1 1 0 2 2 2 0 AAA domain tRNA_anti-codon PF01336.20 AIC16734.1 - 9.1e-13 47.8 2.5 0.00087 19.0 0.0 3.7 3 0 0 3 3 3 3 OB-fold nucleic acid binding domain GCS2 PF04107.8 AIC16735.1 - 2.1e-06 27.0 0.0 4.1e-06 26.1 0.0 1.5 1 1 0 1 1 1 1 Glutamate-cysteine ligase family 2(GCS2) gp32 PF08804.5 AIC16737.1 - 0.027 14.5 0.0 0.028 14.5 0.0 1.2 1 0 0 1 1 1 0 gp32 DNA binding protein like zf-C3HC4_3 PF13920.1 AIC16737.1 - 0.061 13.0 4.7 0.083 12.5 3.3 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CBS PF00571.23 AIC16738.1 - 1.8e-28 98.0 1.7 7e-14 51.3 0.1 2.1 2 0 0 2 2 2 2 CBS domain DEAD_assoc PF08494.6 AIC16739.1 - 2.3e-33 115.4 0.1 4.3e-33 114.6 0.1 1.5 1 0 0 1 1 1 1 DEAD/H associated DEAD PF00270.24 AIC16739.1 - 8.4e-33 113.2 0.3 4.8e-32 110.7 0.1 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.26 AIC16739.1 - 1.1e-18 66.8 0.0 2.1e-17 62.7 0.0 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SNF2_N PF00176.18 AIC16739.1 - 1.3e-07 30.7 0.0 7.2e-07 28.2 0.0 2.0 2 0 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.10 AIC16739.1 - 5.6e-06 26.3 0.0 1.3e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Zn-ribbon_8 PF09723.5 AIC16739.1 - 0.0054 16.6 0.5 0.012 15.5 0.4 1.6 1 0 0 1 1 1 1 Zinc ribbon domain MRC1 PF09444.5 AIC16739.1 - 0.015 15.6 1.0 6.4 7.0 0.1 2.5 2 0 0 2 2 2 0 MRC1-like domain DUF3089 PF11288.3 AIC16739.1 - 0.077 12.1 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3089) DUF1191 PF06697.7 AIC16740.1 - 0.084 11.6 0.0 0.084 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) IncA PF04156.9 AIC16740.1 - 0.09 12.3 0.1 0.096 12.2 0.0 1.0 1 0 0 1 1 1 0 IncA protein FAA_hydrolase_N PF09298.6 AIC16740.1 - 0.11 12.5 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal EphA2_TM PF14575.1 AIC16740.1 - 0.12 12.7 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Baculo_LEF-11 PF06385.7 AIC16741.1 - 0.098 12.7 0.4 5 7.2 0.0 3.6 5 0 0 5 5 5 0 Baculovirus LEF-11 protein HrcA PF01628.16 AIC16741.1 - 0.2 11.2 5.2 0.12 11.9 0.2 2.9 3 1 1 4 4 4 0 HrcA protein C terminal domain Herpes_UL17 PF04559.7 AIC16741.1 - 1.9 6.9 11.0 0.073 11.6 1.0 2.7 2 1 2 4 4 4 0 Herpesvirus UL17 protein Tic20 PF09685.5 AIC16742.1 - 0.011 15.6 0.5 0.011 15.6 0.3 2.5 2 1 0 2 2 2 0 Tic20-like protein Phage_holin_3 PF05106.7 AIC16742.1 - 0.12 12.3 0.4 0.12 12.3 0.3 2.5 2 1 1 3 3 3 0 Phage holin family (Lysis protein S) DUF998 PF06197.8 AIC16742.1 - 1.6 8.0 9.8 1 8.6 2.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF998) DUF373 PF04123.8 AIC16742.1 - 3.8 6.4 8.5 0.7 8.8 2.0 1.8 1 1 0 2 2 2 0 Domain of unknown function (DUF373) Fzo_mitofusin PF04799.8 AIC16743.1 - 0.09 12.1 1.7 0.11 11.8 1.2 1.2 1 0 0 1 1 1 0 fzo-like conserved region DoxX_3 PF13781.1 AIC16743.1 - 0.11 12.9 4.0 0.2 12.0 0.1 2.1 1 1 1 2 2 2 0 DoxX-like family IspA PF04279.10 AIC16743.1 - 0.32 10.9 5.4 0.15 12.0 0.5 2.0 1 1 1 2 2 2 0 Intracellular septation protein A DUF739 PF05339.6 AIC16744.1 - 0.016 15.0 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF739) TrmB PF01978.14 AIC16744.1 - 0.018 14.7 0.1 0.027 14.1 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.2 AIC16744.1 - 0.021 14.6 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Yip1 PF04893.12 AIC16745.1 - 0.85 9.0 16.9 1.3 8.5 11.7 1.3 1 0 0 1 1 1 0 Yip1 domain DDE_Tnp_IS240 PF13610.1 AIC16748.1 - 2.8e-21 75.9 4.3 6.1e-21 74.8 3.0 1.6 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16748.1 - 3e-09 37.0 0.2 5.3e-09 36.2 0.2 1.4 1 0 0 1 1 1 1 Integrase core domain SWIM PF04434.12 AIC16748.1 - 7.4e-06 25.3 0.1 2e-05 23.9 0.1 1.8 1 0 0 1 1 1 1 SWIM zinc finger rve_3 PF13683.1 AIC16748.1 - 0.00065 19.1 0.1 0.00065 19.1 0.1 2.0 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC16748.1 - 0.0048 16.1 0.6 0.0072 15.5 0.4 1.3 1 0 0 1 1 1 1 Transposase IS66 family Transposase_mut PF00872.13 AIC16748.1 - 0.0057 15.2 0.1 1.1 7.7 0.0 2.3 2 0 0 2 2 2 2 Transposase, Mutator family Pox_A14 PF05767.7 AIC16749.1 - 0.26 11.2 5.8 2.5 8.1 4.0 1.9 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 FUSC-like PF12805.2 AIC16749.1 - 0.27 10.1 1.9 0.34 9.7 1.3 1.2 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS DUF3981 PF13139.1 AIC16749.1 - 0.72 9.8 3.7 0.84 9.6 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) DUF3098 PF11297.3 AIC16749.1 - 1.1 9.0 6.2 3.9 7.2 0.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3098) DBB PF14545.1 AIC16750.1 - 0.019 14.5 0.0 0.04 13.4 0.0 1.5 1 0 0 1 1 1 0 Dof, BCAP, and BANK (DBB) motif, Kin17_mid PF10357.4 AIC16753.1 - 0.063 12.9 0.1 0.13 11.8 0.1 1.5 1 0 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein PSD2 PF07624.6 AIC16753.1 - 0.063 12.9 0.1 0.16 11.6 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1585) Collagen PF01391.13 AIC16755.1 - 0.051 13.1 1.8 0.051 13.1 1.2 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) zf-C4H2 PF10146.4 AIC16757.1 - 0.14 12.1 0.0 0.14 12.1 0.0 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein ZZ PF00569.12 AIC16758.1 - 0.097 12.2 0.8 1.7 8.2 0.1 2.1 2 0 0 2 2 2 0 Zinc finger, ZZ type DZR PF12773.2 AIC16758.1 - 0.27 11.0 1.6 1.4 8.7 1.1 1.9 1 1 0 1 1 1 0 Double zinc ribbon Tnp_zf-ribbon_2 PF13842.1 AIC16758.1 - 0.31 11.4 2.5 0.88 10.0 0.2 2.0 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zf-B_box PF00643.19 AIC16758.1 - 0.32 10.9 1.8 4.4 7.2 0.1 2.1 2 0 0 2 2 2 0 B-box zinc finger Fusion_gly PF00523.13 AIC16759.1 - 0.087 10.8 1.4 0.12 10.4 0.9 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 Spore_YhaL PF14147.1 AIC16761.1 - 0.19 11.1 2.3 0.35 10.3 0.2 1.9 1 1 1 2 2 2 0 Sporulation protein YhaL DDE_Tnp_IS240 PF13610.1 AIC16762.1 - 1.1e-23 83.6 1.2 2.5e-23 82.6 0.9 1.6 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16762.1 - 4.8e-09 36.3 0.1 1.1e-08 35.2 0.1 1.7 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 AIC16762.1 - 0.00014 21.2 0.6 0.0006 19.2 0.2 2.2 2 1 0 2 2 2 1 Integrase core domain Zn_Tnp_IS1 PF03811.8 AIC16762.1 - 0.0044 16.4 4.1 0.0044 16.4 2.8 2.0 2 0 0 2 2 2 1 InsA N-terminal domain Transposase_mut PF00872.13 AIC16762.1 - 0.014 13.9 0.4 0.54 8.7 0.0 2.2 2 0 0 2 2 2 0 Transposase, Mutator family DIX PF00778.12 AIC16762.1 - 0.037 13.7 0.4 5.5 6.7 0.0 2.8 3 0 0 3 3 3 0 DIX domain Mut7-C PF01927.11 AIC16762.1 - 0.16 11.9 4.3 0.41 10.6 2.5 2.0 1 1 1 2 2 2 0 Mut7-C RNAse domain C1_4 PF07975.7 AIC16762.1 - 0.16 11.9 5.6 1.4 9.0 1.1 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain Zn-ribbon_8 PF09723.5 AIC16762.1 - 0.31 11.0 2.9 6.7 6.7 0.1 3.2 3 0 0 3 3 3 0 Zinc ribbon domain Antitoxin-MazE PF04014.13 AIC16763.1 - 0.00064 19.3 0.1 0.0012 18.5 0.0 1.5 2 0 0 2 2 2 1 Antidote-toxin recognition MazE DUF308 PF03729.8 AIC16764.1 - 2.5e-11 43.4 51.1 0.00027 20.8 7.4 3.1 1 1 2 3 3 3 3 Short repeat of unknown function (DUF308) Glyoxalase_2 PF12681.2 AIC16765.1 - 8.9e-10 39.1 0.0 1.4e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase-like domain Inhibitor_I10 PF12559.3 AIC16765.1 - 0.037 14.2 0.2 0.081 13.2 0.2 1.5 1 0 0 1 1 1 0 Serine endopeptidase inhibitors Latarcin PF10279.4 AIC16771.1 - 0.016 15.3 0.0 0.017 15.2 0.0 1.1 1 0 0 1 1 1 0 Latarcin precursor ABC2_membrane PF01061.19 AIC16777.1 - 4.2e-38 130.6 22.0 5.5e-38 130.2 15.2 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.2 AIC16777.1 - 3.9e-15 55.7 30.5 3.9e-15 55.7 21.1 1.6 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.2 AIC16777.1 - 1.7e-08 33.6 25.9 1.2e-07 30.8 18.0 2.0 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.2 AIC16777.1 - 2.3e-06 26.9 26.8 2.8e-06 26.6 18.6 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.22 AIC16778.1 - 5e-32 111.0 0.0 7.8e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC16778.1 - 9.8e-12 45.4 0.0 4e-08 33.5 0.0 2.3 1 1 1 2 2 2 2 AAA domain AAA_22 PF13401.1 AIC16778.1 - 0.00012 22.2 0.1 0.00034 20.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.1 AIC16778.1 - 0.00049 19.5 0.3 0.00093 18.6 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.1 AIC16778.1 - 0.00054 19.1 0.0 0.038 13.0 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain SRP54 PF00448.17 AIC16778.1 - 0.00063 19.2 0.1 0.0013 18.2 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_23 PF13476.1 AIC16778.1 - 0.0013 19.1 0.0 0.0025 18.1 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.24 AIC16778.1 - 0.0043 17.2 0.1 0.069 13.3 0.1 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.1 AIC16778.1 - 0.018 14.9 0.0 0.044 13.6 0.0 1.7 1 1 1 2 2 2 0 Putative exonuclease SbcCD, C subunit AAA_19 PF13245.1 AIC16778.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Part of AAA domain UPF0079 PF02367.12 AIC16778.1 - 0.12 12.0 0.1 0.41 10.2 0.0 1.8 2 0 0 2 2 2 0 Uncharacterised P-loop hydrolase UPF0079 DUF4162 PF13732.1 AIC16778.1 - 0.13 12.7 0.0 0.27 11.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) Miro PF08477.8 AIC16778.1 - 0.14 12.6 0.0 0.39 11.2 0.0 1.8 2 0 0 2 2 2 0 Miro-like protein GFA PF04828.9 AIC16779.1 - 0.0076 16.1 2.1 0.017 15.0 1.5 1.5 1 1 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme HypA PF01155.14 AIC16779.1 - 0.0085 15.7 0.6 0.0097 15.5 0.4 1.1 1 0 0 1 1 1 1 Hydrogenase expression/synthesis hypA family zinc_ribbon_2 PF13240.1 AIC16779.1 - 0.0089 15.4 3.4 0.1 12.1 0.2 2.1 2 0 0 2 2 2 1 zinc-ribbon domain zf-ISL3 PF14690.1 AIC16779.1 - 0.015 15.2 4.0 0.053 13.5 0.2 2.2 2 0 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Auto_anti-p27 PF06677.7 AIC16779.1 - 0.016 14.9 3.8 0.039 13.7 0.4 2.1 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.2 AIC16779.1 - 0.036 13.8 4.9 0.062 13.1 3.4 1.4 1 1 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC16779.1 - 0.052 12.7 4.0 0.2 10.8 0.4 2.2 2 0 0 2 2 2 0 zinc-ribbon domain c-SKI_SMAD_bind PF08782.5 AIC16779.1 - 0.054 13.6 0.2 0.063 13.4 0.2 1.1 1 0 0 1 1 1 0 c-SKI Smad4 binding domain zf-C4_Topoisom PF01396.14 AIC16779.1 - 0.063 12.7 0.2 0.063 12.7 0.1 2.0 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger zf-CHY PF05495.7 AIC16779.1 - 0.1 12.7 0.6 0.14 12.3 0.4 1.1 1 0 0 1 1 1 0 CHY zinc finger zf-IS66 PF13005.2 AIC16779.1 - 0.1 12.5 0.4 0.1 12.5 0.3 1.8 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 SIR2 PF02146.12 AIC16779.1 - 0.15 11.7 0.6 0.18 11.5 0.4 1.0 1 0 0 1 1 1 0 Sir2 family zinc_ribbon_4 PF13717.1 AIC16779.1 - 0.38 10.4 8.5 2.9 7.6 5.9 2.0 1 1 0 1 1 1 0 zinc-ribbon domain IBR PF01485.16 AIC16779.1 - 0.43 10.4 4.4 1.7 8.5 3.1 1.7 1 1 0 1 1 1 0 IBR domain zinc_ribbon_5 PF13719.1 AIC16779.1 - 0.58 9.7 8.5 5 6.7 5.9 2.0 1 1 0 1 1 1 0 zinc-ribbon domain DUF2072 PF09845.4 AIC16779.1 - 0.77 9.6 3.5 1.5 8.7 2.4 1.5 1 1 0 1 1 1 0 Zn-ribbon containing protein (DUF2072) Cys_rich_KTR PF14205.1 AIC16779.1 - 0.95 8.9 3.9 6.8 6.2 0.1 2.2 2 0 0 2 2 2 0 Cysteine-rich KTR Elf1 PF05129.8 AIC16779.1 - 0.98 9.1 4.0 1.5 8.6 0.3 1.9 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like DUF2387 PF09526.5 AIC16779.1 - 1 9.3 5.7 0.86 9.5 0.2 2.0 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) Zn-ribbon_8 PF09723.5 AIC16779.1 - 1.2 9.1 5.1 9.7 6.2 3.5 2.0 1 1 0 1 1 1 0 Zinc ribbon domain Ornatin PF02088.10 AIC16779.1 - 1.3 8.6 7.0 1.9 8.1 4.8 1.3 1 0 0 1 1 1 0 Ornatin DUF2082 PF09855.4 AIC16779.1 - 1.4 8.7 5.0 2.1 8.2 0.2 2.1 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-C3HC4_3 PF13920.1 AIC16779.1 - 2.4 7.9 5.0 8.7 6.0 3.6 1.7 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RanBP PF00641.13 AIC16779.1 - 2.6 7.2 7.0 5.3 6.2 0.4 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others ADK_lid PF05191.9 AIC16779.1 - 4 7.1 6.4 23 4.7 4.5 2.1 1 1 1 2 2 2 0 Adenylate kinase, active site lid RNA_binding PF01877.12 AIC16780.1 - 4.6e-15 55.6 0.0 7.5e-15 54.9 0.0 1.3 1 1 0 1 1 1 1 RNA binding AAA_18 PF13238.1 AIC16781.1 - 3.9e-15 56.2 0.0 5.9e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC16781.1 - 6.8e-12 46.2 0.0 1.1e-11 45.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain ADK PF00406.17 AIC16781.1 - 1.1e-05 25.4 0.1 1.2e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_33 PF13671.1 AIC16781.1 - 3.2e-05 23.8 0.1 0.00015 21.6 0.1 1.9 1 1 0 1 1 1 1 AAA domain CoaE PF01121.15 AIC16781.1 - 0.00029 20.3 0.1 0.00084 18.7 0.0 1.8 1 1 1 2 2 2 1 Dephospho-CoA kinase AAA_28 PF13521.1 AIC16781.1 - 0.00031 20.7 0.0 0.00048 20.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 AIC16781.1 - 0.00097 19.4 0.0 0.0026 18.0 0.0 1.6 1 1 0 1 1 1 1 ABC transporter APS_kinase PF01583.15 AIC16781.1 - 0.0011 18.6 0.0 0.0037 16.9 0.0 1.8 2 0 0 2 2 2 1 Adenylylsulphate kinase AAA_22 PF13401.1 AIC16781.1 - 0.0015 18.7 0.1 0.0027 17.8 0.1 1.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.7 AIC16781.1 - 0.0017 17.5 0.0 0.0046 16.0 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin AAA_16 PF13191.1 AIC16781.1 - 0.002 18.1 0.0 0.0037 17.2 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain ArgK PF03308.11 AIC16781.1 - 0.0043 15.8 0.1 0.0082 14.9 0.0 1.4 1 0 0 1 1 1 1 ArgK protein AAA_14 PF13173.1 AIC16781.1 - 0.018 14.9 0.0 0.047 13.5 0.0 1.6 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.5 AIC16781.1 - 0.019 14.1 0.0 0.037 13.2 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NTPase_1 PF03266.10 AIC16781.1 - 0.026 14.2 0.2 0.058 13.0 0.1 1.8 1 1 0 1 1 1 0 NTPase NB-ARC PF00931.17 AIC16781.1 - 0.032 13.1 0.0 0.041 12.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.1 AIC16781.1 - 0.058 12.9 0.0 0.087 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.9 AIC16781.1 - 0.077 12.7 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_19 PF13245.1 AIC16781.1 - 0.11 12.2 0.0 0.29 10.9 0.0 1.6 1 0 0 1 1 1 0 Part of AAA domain Torsin PF06309.6 AIC16781.1 - 0.14 12.0 0.0 0.41 10.5 0.0 1.8 1 1 1 2 2 2 0 Torsin Rhodanese PF00581.15 AIC16782.1 - 2.4e-36 124.4 0.0 4.4e-17 62.4 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain SBP_bac_5 PF00496.17 AIC16782.1 - 0.022 13.5 0.2 0.03 13.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle NIR_SIR PF01077.17 AIC16783.1 - 1.3e-41 141.5 0.1 7.8e-30 103.3 0.0 2.5 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.12 AIC16783.1 - 1.3e-33 114.4 0.1 1.1e-18 66.5 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Glyoxalase_2 PF12681.2 AIC16784.1 - 1.2e-14 54.8 0.0 1.6e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.20 AIC16784.1 - 2.1e-06 27.7 0.0 8.1e-06 25.8 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.1 AIC16784.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.7 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Ribosomal_L2_C PF03947.13 AIC16785.1 - 4.3e-35 120.3 1.9 6.8e-35 119.7 1.3 1.3 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.18 AIC16785.1 - 4.1e-11 42.6 0.1 9.2e-11 41.5 0.1 1.6 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain ATP-gua_Ptrans PF00217.14 AIC16786.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 ATP:guanido phosphotransferase, C-terminal catalytic domain TFIIE_alpha PF02002.12 AIC16786.1 - 0.2 11.1 1.3 2.5 7.6 0.2 2.2 2 1 0 2 2 2 0 TFIIE alpha subunit HhH-GPD PF00730.20 AIC16787.1 - 1.9e-19 69.9 0.0 2.4e-19 69.6 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH_5 PF14520.1 AIC16787.1 - 0.067 13.3 0.0 0.8 9.9 0.0 2.4 2 1 0 2 2 2 0 Helix-hairpin-helix domain PAC2 PF09754.4 AIC16788.1 - 3e-27 95.8 0.0 3.7e-27 95.5 0.0 1.0 1 0 0 1 1 1 1 PAC2 family Choline_kinase PF01633.15 AIC16789.1 - 0.11 12.0 0.0 0.48 9.9 0.0 1.8 2 0 0 2 2 2 0 Choline/ethanolamine kinase tRNA_NucTransf2 PF09249.6 AIC16790.1 - 3.9e-36 123.3 0.0 7.9e-36 122.4 0.0 1.5 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain NTP_transf_2 PF01909.18 AIC16790.1 - 5.9e-10 39.3 0.0 1.2e-09 38.3 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain AP2 PF00847.15 AIC16790.1 - 0.084 13.0 0.6 7 6.8 0.0 2.9 3 0 0 3 3 3 0 AP2 domain LigT_PEase PF02834.11 AIC16791.1 - 6.6e-24 83.7 0.1 3.6e-14 52.4 0.0 2.1 2 0 0 2 2 2 2 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.1 AIC16791.1 - 9.8e-13 48.0 0.0 1.2e-12 47.8 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily AKAP7_NLS PF10469.4 AIC16791.1 - 3.3e-09 36.7 0.0 4.5e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain DS PF01916.12 AIC16793.1 - 1.2e-49 169.0 0.0 1.5e-49 168.7 0.0 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase SelP_N PF04592.9 AIC16793.1 - 1 8.7 7.7 1.7 7.9 5.4 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DS PF01916.12 AIC16794.1 - 1.6e-73 247.4 0.0 1.9e-73 247.2 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase SnoaL_2 PF12680.2 AIC16795.1 - 1.5e-08 34.9 0.0 2e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.1 AIC16795.1 - 7.1e-07 29.2 0.1 1.7e-06 28.0 0.0 1.6 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.1 AIC16795.1 - 5.1e-06 26.6 0.0 6.3e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) CUB PF00431.15 AIC16795.1 - 0.021 14.8 0.0 0.03 14.4 0.0 1.2 1 0 0 1 1 1 0 CUB domain DUF4253 PF14062.1 AIC16795.1 - 0.088 12.4 0.1 0.11 12.1 0.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4253) Inositol_P PF00459.20 AIC16796.1 - 5.1e-50 170.2 0.0 5.6e-50 170.1 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.15 AIC16796.1 - 0.0015 17.3 0.0 0.0023 16.8 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase Pro_isomerase PF00160.16 AIC16797.1 - 3.1e-48 163.9 0.1 4.9e-48 163.2 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD STT3 PF02516.9 AIC16797.1 - 1.6e-43 149.4 29.6 2.4e-43 148.8 20.5 1.2 1 0 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.1 AIC16797.1 - 1e-07 32.0 18.3 1e-07 32.0 12.7 3.3 3 1 0 3 3 3 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Lactamase_B_3 PF13483.1 AIC16798.1 - 5.7e-30 104.1 0.8 6.8e-30 103.9 0.6 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.2 AIC16798.1 - 5.7e-16 58.6 0.2 7.4e-16 58.2 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.22 AIC16798.1 - 0.02 14.5 1.5 0.38 10.3 0.5 2.2 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily XdhC_C PF13478.1 AIC16798.1 - 0.07 13.4 1.3 0.77 10.0 0.1 2.7 1 1 1 2 2 2 0 XdhC Rossmann domain Fcf1 PF04900.7 AIC16799.1 - 9.6e-10 38.4 0.1 1.2e-09 38.1 0.0 1.1 1 0 0 1 1 1 1 Fcf1 DUF188 PF02639.9 AIC16799.1 - 0.0087 15.4 0.4 0.012 15.0 0.3 1.1 1 0 0 1 1 1 1 Uncharacterized BCR, YaiI/YqxD family COG1671 PIN_4 PF13638.1 AIC16799.1 - 0.049 13.7 0.5 0.14 12.2 0.3 1.8 1 1 0 1 1 1 0 PIN domain PIN PF01850.16 AIC16799.1 - 0.061 13.6 0.5 0.18 12.1 0.3 1.7 1 1 0 1 1 1 0 PIN domain GTP_EFTU PF00009.22 AIC16800.1 - 6.3e-41 139.8 0.0 9.8e-41 139.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.6 AIC16800.1 - 3.7e-27 94.1 0.6 9.6e-27 92.8 0.1 1.9 2 0 0 2 2 2 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.20 AIC16800.1 - 0.001 19.1 0.6 0.0025 17.8 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AIC16800.1 - 0.014 15.3 0.0 0.051 13.5 0.0 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase Ribosomal_S6e PF01092.14 AIC16801.1 - 1.3e-19 70.1 0.9 1.6e-19 69.8 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S6e Ribosomal_60s PF00428.14 AIC16801.1 - 1.9 8.9 11.3 3.3 8.1 7.8 1.5 1 1 0 1 1 1 0 60s Acidic ribosomal protein UPF0150 PF03681.10 AIC16802.1 - 0.0017 17.9 0.0 0.0022 17.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0150) EcsC PF12787.2 AIC16802.1 - 0.022 14.1 0.1 0.025 13.9 0.1 1.0 1 0 0 1 1 1 0 EcsC protein family DUF99 PF01949.11 AIC16802.1 - 0.078 12.0 0.1 0.089 11.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF99 TctC PF03401.9 AIC16802.1 - 0.1 11.5 0.0 0.11 11.3 0.0 1.3 1 0 0 1 1 1 0 Tripartite tricarboxylate transporter family receptor ARPC4 PF05856.7 AIC16802.1 - 0.12 11.7 0.0 0.13 11.6 0.0 1.0 1 0 0 1 1 1 0 ARP2/3 complex 20 kDa subunit (ARPC4) DUF3832 PF12909.2 AIC16802.1 - 0.13 12.3 0.0 0.15 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3832) HTH_23 PF13384.1 AIC16803.1 - 1.3e-08 34.2 0.1 3.9e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 Homeodomain-like domain HTH_38 PF13936.1 AIC16803.1 - 4e-08 32.6 0.1 8e-08 31.7 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_28 PF13518.1 AIC16803.1 - 4.6e-06 26.5 0.3 1.2e-05 25.2 0.2 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.7 AIC16803.1 - 5.1e-06 25.8 0.4 1.3e-05 24.5 0.2 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_40 PF14493.1 AIC16803.1 - 7.1e-05 22.9 0.3 0.00017 21.7 0.2 1.7 1 1 0 1 1 1 1 Helix-turn-helix domain GerE PF00196.14 AIC16803.1 - 0.00013 21.2 2.4 0.00065 18.9 0.1 2.5 2 1 1 3 3 3 1 Bacterial regulatory proteins, luxR family Sigma70_r4 PF04545.11 AIC16803.1 - 0.00029 20.0 0.1 0.00052 19.2 0.1 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Arg_repressor PF01316.16 AIC16803.1 - 0.00052 19.5 0.1 0.0011 18.5 0.1 1.6 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain Sigma70_ECF PF07638.6 AIC16803.1 - 0.00084 19.0 0.0 0.0015 18.2 0.0 1.3 1 0 0 1 1 1 1 ECF sigma factor HTH_29 PF13551.1 AIC16803.1 - 0.0013 18.8 0.1 0.0027 17.8 0.0 1.6 1 1 0 1 1 1 1 Winged helix-turn helix Terminase_5 PF06056.7 AIC16803.1 - 0.0021 17.5 0.0 0.0059 16.1 0.0 1.7 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.14 AIC16803.1 - 0.0028 17.5 0.1 0.005 16.7 0.1 1.4 1 0 0 1 1 1 1 Trp repressor protein HTH_24 PF13412.1 AIC16803.1 - 0.0036 16.6 0.2 0.011 15.1 0.1 1.9 2 0 0 2 2 1 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.15 AIC16803.1 - 0.0061 16.2 0.0 0.018 14.7 0.0 1.8 1 1 1 2 2 2 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.7 AIC16803.1 - 0.0067 16.0 0.2 0.012 15.2 0.1 1.5 1 0 0 1 1 1 1 HTH domain CENP-B_N PF04218.8 AIC16803.1 - 0.0082 15.5 0.1 0.015 14.6 0.0 1.4 1 0 0 1 1 1 1 CENP-B N-terminal DNA-binding domain MarR PF01047.17 AIC16803.1 - 0.013 15.1 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 MarR family KorB PF08535.5 AIC16803.1 - 0.013 15.5 0.3 0.028 14.5 0.2 1.8 1 1 0 1 1 1 0 KorB domain HTH_3 PF01381.17 AIC16803.1 - 0.019 14.8 0.3 0.019 14.8 0.2 1.7 2 0 0 2 2 1 0 Helix-turn-helix MarR_2 PF12802.2 AIC16803.1 - 0.02 14.5 0.1 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_Tnp_ISL3 PF13542.1 AIC16803.1 - 0.024 13.8 0.0 0.051 12.7 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Cro PF09048.5 AIC16803.1 - 0.027 14.0 0.1 0.055 13.1 0.0 1.5 1 0 0 1 1 1 0 Cro HTH_37 PF13744.1 AIC16803.1 - 0.028 14.2 0.1 0.055 13.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_7 PF02796.10 AIC16803.1 - 0.039 13.8 0.0 0.076 12.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase DUF1071 PF06378.6 AIC16803.1 - 0.042 13.0 0.2 0.067 12.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) RepB PF07506.6 AIC16803.1 - 0.051 13.4 0.4 0.14 11.9 0.3 1.8 1 1 0 1 1 1 0 RepB plasmid partitioning protein HTH_Crp_2 PF13545.1 AIC16803.1 - 0.051 13.3 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.5 AIC16803.1 - 0.074 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_31 PF13560.1 AIC16803.1 - 0.074 13.2 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain ESAG1 PF03238.8 AIC16803.1 - 0.082 12.1 0.2 0.11 11.7 0.1 1.2 1 0 0 1 1 1 0 ESAG protein KfrA_N PF11740.3 AIC16803.1 - 0.19 12.1 2.8 0.33 11.4 2.0 1.3 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term EF-hand_7 PF13499.1 AIC16804.1 - 0.032 14.3 0.4 0.1 12.7 0.3 1.9 1 0 0 1 1 1 0 EF-hand domain pair Myb_DNA-bind_5 PF13873.1 AIC16804.1 - 4.4 7.2 12.2 0.76 9.7 5.4 2.0 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain TFIIE_alpha PF02002.12 AIC16806.1 - 0.011 15.1 0.1 0.013 14.9 0.1 1.1 1 0 0 1 1 1 0 TFIIE alpha subunit HTH_24 PF13412.1 AIC16806.1 - 0.042 13.2 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_45 PF14947.1 AIC16806.1 - 0.085 12.6 0.1 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix PP_kinase_C PF13090.1 AIC16806.1 - 0.091 11.3 0.0 0.091 11.3 0.0 1.2 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain HTH_20 PF12840.2 AIC16806.1 - 0.094 12.5 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain TF_Zn_Ribbon PF08271.7 AIC16807.1 - 0.00015 21.0 1.2 0.0002 20.6 0.8 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding DNA_RNApol_7kD PF03604.8 AIC16807.1 - 0.0011 18.3 1.0 0.0017 17.7 0.7 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_5 PF13719.1 AIC16807.1 - 0.0031 17.0 3.1 0.0084 15.6 2.2 1.7 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC16807.1 - 0.0033 17.0 2.6 0.013 15.1 1.8 1.8 1 1 0 1 1 1 1 zinc-ribbon domain DZR PF12773.2 AIC16807.1 - 0.0042 16.8 0.9 0.006 16.3 0.6 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC16807.1 - 0.0045 16.1 5.0 0.02 14.0 3.5 1.9 1 1 1 2 2 2 1 zinc-ribbon domain Prok-RING_1 PF14446.1 AIC16807.1 - 0.0053 16.4 1.5 0.0083 15.8 1.0 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 Ribosomal_S27e PF01667.12 AIC16807.1 - 0.014 14.9 0.5 0.018 14.5 0.4 1.2 1 0 0 1 1 1 0 Ribosomal protein S27 OrfB_Zn_ribbon PF07282.6 AIC16807.1 - 0.016 14.8 1.7 0.022 14.3 1.1 1.3 1 1 0 1 1 1 0 Putative transposase DNA-binding domain Lar_restr_allev PF14354.1 AIC16807.1 - 0.017 15.3 2.0 0.26 11.5 1.4 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF2387 PF09526.5 AIC16807.1 - 0.025 14.4 1.8 0.036 13.9 1.3 1.3 1 1 0 1 1 1 0 Probable metal-binding protein (DUF2387) UPF0547 PF10571.4 AIC16807.1 - 0.031 13.9 5.0 0.18 11.5 3.5 1.9 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 zinc-ribbons_6 PF07191.7 AIC16807.1 - 0.035 13.8 0.6 0.042 13.6 0.4 1.2 1 0 0 1 1 1 0 zinc-ribbons HypA PF01155.14 AIC16807.1 - 0.036 13.7 0.3 0.039 13.6 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family IBR PF01485.16 AIC16807.1 - 0.041 13.7 1.2 0.066 13.0 0.8 1.3 1 0 0 1 1 1 0 IBR domain zinc_ribbon_2 PF13240.1 AIC16807.1 - 0.043 13.3 5.6 0.19 11.2 3.9 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zf-H2C2_2 PF13465.1 AIC16807.1 - 0.043 14.1 4.5 3.7 8.0 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain CpXC PF14353.1 AIC16807.1 - 0.055 13.4 2.1 0.77 9.7 0.1 2.1 1 1 1 2 2 2 0 CpXC protein Ogr_Delta PF04606.7 AIC16807.1 - 0.056 13.1 0.6 0.94 9.1 0.1 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger RNA_POL_M_15KD PF02150.11 AIC16807.1 - 0.058 13.1 0.8 0.11 12.1 0.6 1.5 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit DUF2225 PF09986.4 AIC16807.1 - 0.065 12.6 1.4 0.16 11.4 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) YyzF PF14116.1 AIC16807.1 - 0.067 13.1 4.6 0.096 12.6 0.2 2.2 1 1 1 2 2 2 0 YyzF-like protein zf-C4_ClpX PF06689.8 AIC16807.1 - 0.073 12.6 0.4 0.52 9.8 0.0 2.0 2 0 0 2 2 2 0 ClpX C4-type zinc finger Zn-ribbon_8 PF09723.5 AIC16807.1 - 0.087 12.7 4.6 1 9.3 3.2 2.1 1 1 0 1 1 1 0 Zinc ribbon domain DUF329 PF03884.9 AIC16807.1 - 0.097 12.2 2.0 1.2 8.7 2.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF329) DUF2082 PF09855.4 AIC16807.1 - 0.13 12.0 6.5 1.4 8.8 0.5 2.2 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Elf1 PF05129.8 AIC16807.1 - 0.15 11.7 1.3 0.44 10.2 0.9 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like A2L_zn_ribbon PF08792.5 AIC16807.1 - 0.17 11.3 2.6 7 6.2 1.8 2.3 1 1 0 1 1 1 0 A2L zinc ribbon domain zf-C2H2_4 PF13894.1 AIC16807.1 - 0.18 12.2 0.9 11 6.6 0.1 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger zf-TFIIB PF13453.1 AIC16807.1 - 0.24 10.6 1.3 0.34 10.1 0.9 1.3 1 0 0 1 1 1 0 Transcription factor zinc-finger zf-ISL3 PF14690.1 AIC16807.1 - 0.24 11.4 3.8 0.96 9.5 1.8 2.0 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Mu-like_Com PF10122.4 AIC16807.1 - 0.4 9.7 3.1 1.5 7.9 0.1 2.1 1 1 1 2 2 2 0 Mu-like prophage protein Com zf-C4_Topoisom PF01396.14 AIC16807.1 - 0.46 10.0 2.7 0.5 9.9 0.4 1.9 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Rubredoxin PF00301.15 AIC16807.1 - 0.69 9.8 3.3 9 6.2 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin Zn_Tnp_IS1595 PF12760.2 AIC16807.1 - 0.91 9.3 4.6 5.1 6.9 0.6 2.2 1 1 1 2 2 2 0 Transposase zinc-ribbon domain ProRS-C_1 PF09180.6 AIC16807.1 - 1.1 9.1 3.8 8.9 6.3 0.9 2.1 1 1 1 2 2 2 0 Prolyl-tRNA synthetase, C-terminal zf-HIT PF04438.11 AIC16807.1 - 1.3 8.7 5.7 9.4 5.9 0.1 2.1 2 0 0 2 2 2 0 HIT zinc finger zf-C2HC_2 PF13913.1 AIC16807.1 - 1.8 8.3 4.4 3.7 7.3 0.6 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Auto_anti-p27 PF06677.7 AIC16807.1 - 2.2 8.1 6.0 1.1 9.0 0.8 2.3 3 0 0 3 3 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-C2H2 PF00096.21 AIC16807.1 - 7.8 7.0 5.9 21 5.7 1.0 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF899 PF05988.7 AIC16808.1 - 4e-97 323.7 1.3 4.7e-97 323.5 0.9 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) AhpC-TSA PF00578.16 AIC16808.1 - 3e-05 23.7 0.0 4.5e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family DSPc PF00782.15 AIC16810.1 - 6.9e-18 64.5 0.0 8.7e-18 64.1 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.1 AIC16810.1 - 1.6e-07 31.4 0.0 2.6e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.22 AIC16810.1 - 2.9e-07 30.0 0.0 3.7e-07 29.7 0.0 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.1 AIC16810.1 - 4.7e-06 26.9 0.1 8.7e-06 26.0 0.0 1.5 1 1 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.8 AIC16810.1 - 0.0028 17.0 0.0 0.0058 16.0 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Rieske PF00355.21 AIC16812.1 - 1e-16 60.2 0.1 1.4e-16 59.8 0.0 1.2 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 AIC16812.1 - 1.7e-08 34.0 0.0 2.9e-08 33.3 0.0 1.4 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF320 PF03777.8 AIC16812.1 - 0.082 12.6 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Small secreted domain (DUF320) THF_DHG_CYH_C PF02882.14 AIC16814.1 - 0.11 11.5 0.0 0.14 11.1 0.0 1.3 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain tRNA-synt_1 PF00133.17 AIC16815.1 - 5.1e-137 457.4 0.0 7.2e-137 456.9 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.8 AIC16815.1 - 1.1e-27 96.6 0.2 4.2e-27 94.7 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.6 AIC16815.1 - 7.4e-23 80.8 1.5 1.7e-09 36.8 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 AIC16815.1 - 1.4e-05 24.4 0.0 0.00011 21.4 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.13 AIC16815.1 - 0.00017 20.3 0.0 0.00042 19.1 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (K) Lar_restr_allev PF14354.1 AIC16815.1 - 0.03 14.6 0.4 1.8 8.9 0.1 2.6 2 0 0 2 2 2 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.5 AIC16815.1 - 0.14 12.1 2.9 0.53 10.2 0.0 2.9 3 0 0 3 3 3 0 Zinc ribbon domain zinc_ribbon_2 PF13240.1 AIC16815.1 - 1.2 8.7 7.9 2.1 7.9 0.0 3.4 3 0 0 3 3 3 0 zinc-ribbon domain DZR PF12773.2 AIC16815.1 - 1.9 8.3 3.9 38 4.2 0.0 2.7 2 1 0 2 2 2 0 Double zinc ribbon DEP PF00610.16 AIC16816.1 - 0.051 13.3 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF4397 PF14344.1 AIC16817.1 - 0.13 12.5 0.0 0.17 12.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4397) DUF192 PF02643.10 AIC16818.1 - 7.6e-30 102.7 0.0 1.1e-29 102.2 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 TrmB PF01978.14 AIC16819.1 - 4.1e-16 58.4 1.2 9.8e-16 57.2 0.2 2.0 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Transglycosylas PF06737.9 AIC16819.1 - 0.068 13.4 0.2 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 Transglycosylase-like domain MarR_2 PF12802.2 AIC16819.1 - 0.07 12.8 0.0 0.24 11.0 0.0 2.0 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.1 AIC16819.1 - 0.09 12.1 0.3 0.47 9.8 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF892 PF05974.7 AIC16820.1 - 0.045 13.5 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF892) eIF_4EBP PF05456.6 AIC16821.1 - 0.1 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) AAA PF00004.24 AIC16822.1 - 4.8e-37 127.1 0.0 2.3e-36 124.8 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.13 AIC16822.1 - 6e-08 32.4 4.6 9.3e-08 31.8 2.2 2.0 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain AAA_22 PF13401.1 AIC16822.1 - 1.1e-05 25.5 0.1 0.00023 21.3 0.0 2.8 1 1 1 2 2 2 1 AAA domain AAA_2 PF07724.9 AIC16822.1 - 3.8e-05 23.6 0.0 0.00012 22.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.1 AIC16822.1 - 7.5e-05 22.7 0.0 0.00074 19.5 0.0 2.4 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.1 AIC16822.1 - 9.2e-05 22.3 0.0 0.0005 19.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.1 AIC16822.1 - 0.00013 22.7 0.0 0.00099 19.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AIC16822.1 - 0.00018 20.9 0.3 0.006 16.0 0.1 2.4 1 1 0 2 2 2 1 AAA domain RuvB_N PF05496.7 AIC16822.1 - 0.00021 20.4 0.0 0.00041 19.4 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase ruvB N-terminus Zeta_toxin PF06414.7 AIC16822.1 - 0.00049 19.2 0.0 0.0011 18.0 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin RNA_helicase PF00910.17 AIC16822.1 - 0.00057 20.0 0.1 0.097 12.8 0.0 2.7 2 1 0 2 2 2 1 RNA helicase AAA_5 PF07728.9 AIC16822.1 - 0.0017 18.1 0.0 0.028 14.1 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Vps4_C PF09336.5 AIC16822.1 - 0.0022 17.8 0.1 0.0092 15.8 0.0 2.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_19 PF13245.1 AIC16822.1 - 0.0042 16.8 0.0 0.01 15.5 0.0 1.6 1 0 0 1 1 1 1 Part of AAA domain AAA_33 PF13671.1 AIC16822.1 - 0.0063 16.3 0.0 0.013 15.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.1 AIC16822.1 - 0.0067 16.0 0.0 0.018 14.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.12 AIC16822.1 - 0.0098 15.3 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TPR_11 PF13414.1 AIC16822.1 - 0.01 15.4 0.9 0.026 14.1 0.6 1.7 1 0 0 1 1 1 0 TPR repeat AAA_18 PF13238.1 AIC16822.1 - 0.014 15.7 0.0 0.042 14.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain KAP_NTPase PF07693.9 AIC16822.1 - 0.017 14.1 0.0 0.14 11.1 0.0 2.0 1 1 1 2 2 2 0 KAP family P-loop domain Mg_chelatase PF01078.16 AIC16822.1 - 0.021 13.9 0.0 0.044 12.9 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI TIP49 PF06068.8 AIC16822.1 - 0.028 13.1 0.0 0.064 11.9 0.0 1.6 1 1 1 2 2 2 0 TIP49 C-terminus Arch_ATPase PF01637.13 AIC16822.1 - 0.062 12.9 0.0 0.6 9.7 0.0 2.2 2 1 1 3 3 2 0 Archaeal ATPase KaiC PF06745.8 AIC16822.1 - 0.092 11.8 0.0 1.1 8.3 0.0 2.5 1 1 1 2 2 2 0 KaiC PhoH PF02562.11 AIC16822.1 - 0.11 11.7 0.1 0.21 10.8 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein NACHT PF05729.7 AIC16822.1 - 0.12 12.0 0.0 0.81 9.3 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_28 PF13521.1 AIC16822.1 - 0.15 12.0 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain CHB_HEX_C PF03174.8 AIC16823.1 - 2.6e-35 120.1 22.7 6e-20 70.8 3.0 5.1 5 1 1 6 6 6 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.1 AIC16823.1 - 6.6e-29 99.7 30.4 3.6e-16 59.0 3.1 4.2 4 0 0 4 4 4 2 Fn3 associated CHB_HEX_C_1 PF13290.1 AIC16823.1 - 7.2e-29 99.3 22.1 2.6e-17 62.3 3.5 5.1 7 0 0 7 7 7 2 Chitobiase/beta-hexosaminidase C-terminal domain HYR PF02494.11 AIC16823.1 - 1.5e-15 56.9 12.9 1.3e-07 31.4 1.4 3.8 3 0 0 3 3 3 2 HYR domain Polysacc_deac_1 PF01522.16 AIC16823.1 - 1.1e-11 44.4 0.1 3.6e-11 42.7 0.0 1.9 2 0 0 2 2 2 1 Polysaccharide deacetylase Y_Y_Y PF07495.8 AIC16823.1 - 0.019 14.7 0.1 7.8 6.3 0.0 2.7 2 0 0 2 2 2 0 Y_Y_Y domain Glyco_hydro_57 PF03065.10 AIC16823.1 - 0.037 12.9 0.0 0.071 11.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 CARDB PF07705.6 AIC16823.1 - 0.11 12.5 18.6 0.076 13.0 1.2 4.5 4 0 0 4 4 4 0 CARDB Pyrophosphatase PF00719.14 AIC16824.1 - 4.3e-60 201.6 1.5 5e-60 201.4 1.0 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase RNaseH_C PF09293.5 AIC16824.1 - 0.024 14.5 0.4 0.06 13.2 0.1 1.6 1 1 0 1 1 1 0 T4 RNase H, C terminal DUF3646 PF12362.3 AIC16825.1 - 0.024 14.5 0.1 0.052 13.5 0.0 1.6 2 0 0 2 2 2 0 DNA polymerase III gamma and tau subunits C terminal Hydrolase_3 PF08282.7 AIC16826.1 - 7.1e-25 88.0 0.0 1.8e-16 60.5 0.0 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.21 AIC16826.1 - 1.2e-06 29.1 0.6 0.00052 20.4 0.1 2.7 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AIC16826.1 - 6e-05 23.2 0.0 0.026 14.7 0.0 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.8 AIC16826.1 - 0.00013 21.4 0.0 0.17 11.1 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase_like PF13242.1 AIC16826.1 - 0.014 15.0 0.0 0.03 14.0 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like Acid_phosphat_B PF03767.9 AIC16826.1 - 0.067 12.5 0.0 1.8 7.9 0.0 2.2 1 1 1 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) LNS2 PF08235.8 AIC16826.1 - 0.088 12.3 0.1 0.2 11.1 0.0 1.7 1 1 0 1 1 1 0 LNS2 (Lipin/Ned1/Smp2) tRNA-synt_1d PF00750.14 AIC16827.1 - 5.5e-40 137.2 2.1 1.3e-27 96.5 0.1 2.5 1 1 1 2 2 2 2 tRNA synthetases class I (R) DALR_1 PF05746.10 AIC16827.1 - 2.2e-31 108.3 3.1 2.2e-31 108.3 2.2 1.8 2 0 0 2 2 2 1 DALR anticodon binding domain Arg_tRNA_synt_N PF03485.11 AIC16827.1 - 6e-17 61.9 0.1 2.5e-16 59.9 0.0 2.2 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1g PF09334.6 AIC16827.1 - 0.014 14.0 0.7 0.021 13.4 0.1 1.5 2 0 0 2 2 2 0 tRNA synthetases class I (M) tRNA-synt_1e PF01406.14 AIC16827.1 - 0.083 11.9 0.3 0.17 10.9 0.2 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain ParA PF10609.4 AIC16828.1 - 0.13 12.1 0.3 0.17 11.7 0.2 1.2 1 0 0 1 1 1 0 ParA/MinD ATPase like HypA PF01155.14 AIC16828.1 - 0.49 10.0 3.0 0.57 9.8 2.1 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family GCD14 PF08704.5 AIC16830.1 - 5.2e-36 124.3 0.0 2.2e-33 115.8 0.0 2.1 1 1 1 2 2 2 2 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.14 AIC16830.1 - 2.1e-09 37.2 0.0 3e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.1 AIC16830.1 - 2.6e-09 36.8 0.0 3.5e-09 36.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC16830.1 - 1.5e-08 35.1 0.0 3.3e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC16830.1 - 1.3e-07 31.6 0.0 1.2e-06 28.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC16830.1 - 1.7e-06 27.3 0.0 2.5e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_3 PF01596.12 AIC16830.1 - 3.4e-05 23.0 0.0 6.1e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_11 PF08241.7 AIC16830.1 - 0.00019 21.8 0.0 0.00037 20.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC16830.1 - 0.00041 20.6 0.0 0.00068 19.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain DUF2827 PF10933.3 AIC16830.1 - 0.0018 16.8 0.0 0.0022 16.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2827) Methyltransf_12 PF08242.7 AIC16830.1 - 0.0027 18.1 0.0 0.0058 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.13 AIC16830.1 - 0.0043 16.6 0.0 0.011 15.3 0.0 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Fibrillarin PF01269.12 AIC16830.1 - 0.0045 15.9 0.0 0.0075 15.2 0.0 1.4 1 0 0 1 1 1 1 Fibrillarin PrmA PF06325.8 AIC16830.1 - 0.013 14.6 0.0 0.018 14.1 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.9 AIC16830.1 - 0.014 14.7 0.0 0.03 13.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_21 PF05050.7 AIC16830.1 - 0.02 14.8 0.0 1.6 8.6 0.0 2.3 1 1 0 2 2 2 0 Methyltransferase FkbM domain RrnaAD PF00398.15 AIC16830.1 - 0.028 13.4 0.0 0.04 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase DUF938 PF06080.7 AIC16830.1 - 0.061 12.8 0.0 0.098 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) Gcd10p PF04189.8 AIC16830.1 - 0.1 11.7 0.1 0.15 11.1 0.0 1.3 1 0 0 1 1 1 0 Gcd10p family Slx4 PF09494.5 AIC16832.1 - 0.13 11.9 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Slx4 endonuclease DUF4367 PF14285.1 AIC16832.1 - 0.13 11.5 0.0 0.14 11.4 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) Copper-bind PF00127.15 AIC16833.1 - 0.00028 21.0 0.0 0.00075 19.6 0.0 1.7 2 0 0 2 2 2 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC16833.1 - 0.097 12.5 0.0 0.41 10.5 0.0 2.0 2 1 0 2 2 2 0 Cupredoxin-like domain Phage_GP20 PF06810.6 AIC16834.1 - 0.013 14.9 0.6 0.013 14.9 0.4 1.9 2 0 0 2 2 2 0 Phage minor structural protein GP20 DDE_Tnp_IS240 PF13610.1 AIC16837.1 - 8.9e-10 38.6 0.0 1.4e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16837.1 - 2.3e-05 24.4 0.2 4.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC16837.1 - 0.00017 20.8 0.6 0.00033 19.9 0.3 1.6 1 1 0 1 1 1 1 Transposase IS66 family DUF4206 PF13901.1 AIC16837.1 - 0.029 13.9 0.7 0.04 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) YtpI PF14007.1 AIC16839.1 - 0.22 11.4 1.8 0.58 10.1 0.1 2.2 2 0 0 2 2 2 0 YtpI-like protein TrbL PF04610.9 AIC16840.1 - 3.8 7.1 36.9 1 8.9 17.9 3.1 1 1 2 3 3 3 0 TrbL/VirB6 plasmid conjugal transfer protein GRAM PF02893.15 AIC16841.1 - 3.8e-05 23.1 0.0 7.9e-05 22.1 0.0 1.5 1 0 0 1 1 1 1 GRAM domain DUF349 PF03993.7 AIC16841.1 - 0.0056 16.8 0.6 1 9.5 0.0 2.5 2 0 0 2 2 2 2 Domain of Unknown Function (DUF349) PglZ PF08665.7 AIC16841.1 - 0.042 13.5 0.3 0.073 12.7 0.2 1.5 1 0 0 1 1 1 0 PglZ domain Vps36_ESCRT-II PF11605.3 AIC16841.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 ARGLU PF15346.1 AIC16841.1 - 1.9 8.2 7.1 0.66 9.7 2.5 1.8 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Arch_ATPase PF01637.13 AIC16842.1 - 3.3e-19 69.5 0.1 6.2e-19 68.6 0.0 1.5 1 1 0 1 1 1 1 Archaeal ATPase AAA_14 PF13173.1 AIC16842.1 - 1.4e-10 41.1 0.0 5.6e-06 26.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.1 AIC16842.1 - 2.6e-10 40.5 0.0 4.8e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.1 AIC16842.1 - 1.6e-09 38.0 0.3 3.3e-08 33.7 0.2 2.6 1 1 0 1 1 1 1 AAA domain AAA_35 PF14516.1 AIC16842.1 - 5.7e-05 21.8 0.0 0.00017 20.3 0.0 1.9 1 1 1 2 2 2 1 AAA-like domain AAA-ATPase_like PF09820.4 AIC16842.1 - 0.0045 16.1 0.1 0.011 14.8 0.0 1.7 2 0 0 2 2 2 1 Predicted AAA-ATPase TrmB PF01978.14 AIC16842.1 - 0.011 15.3 0.1 0.036 13.7 0.0 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.1 AIC16842.1 - 0.012 15.8 0.0 0.034 14.4 0.0 1.8 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_45 PF14947.1 AIC16842.1 - 0.019 14.7 0.0 0.088 12.6 0.0 2.1 2 0 0 2 2 2 0 Winged helix-turn-helix NTPase_1 PF03266.10 AIC16842.1 - 0.025 14.2 0.1 0.14 11.8 0.0 2.1 1 1 0 2 2 2 0 NTPase AAA PF00004.24 AIC16842.1 - 0.085 13.0 0.1 0.51 10.5 0.0 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Colicin_Ia PF11504.3 AIC16842.1 - 0.12 12.3 0.1 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 Colicin Ia AAA_17 PF13207.1 AIC16842.1 - 0.13 13.1 1.4 1.1 10.0 0.3 2.7 2 1 0 2 2 2 0 AAA domain Cas_Cas6 PF01881.11 AIC16843.1 - 2.4e-13 50.6 0.0 4e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 CRISPR associated protein Cas6 DEAD PF00270.24 AIC16844.1 - 3.6e-10 39.6 0.0 2e-09 37.1 0.0 2.3 1 1 0 1 1 1 1 DEAD/DEAH box helicase HD PF01966.17 AIC16844.1 - 0.00019 21.4 0.9 0.0022 18.0 0.0 2.5 2 0 0 2 2 2 1 HD domain Helicase_C PF00271.26 AIC16844.1 - 0.015 15.1 0.1 0.13 12.1 0.0 2.4 2 0 0 2 2 2 0 Helicase conserved C-terminal domain AAA_19 PF13245.1 AIC16844.1 - 0.07 12.8 0.0 0.91 9.3 0.0 2.5 2 0 0 2 2 2 0 Part of AAA domain Cas_Cas5d PF09704.5 AIC16845.1 - 5.6e-13 49.0 0.1 6.3e-13 48.8 0.0 1.1 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas5) RAMPs PF03787.10 AIC16845.1 - 0.1 12.4 0.3 0.15 11.8 0.2 1.5 1 1 0 1 1 1 0 RAMP superfamily DevR PF01905.11 AIC16846.1 - 7.6e-28 97.0 0.0 1.1e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 CRISPR-associated negative auto-regulator DevR/Csa2 Cas_CXXC_CXXC PF09706.5 AIC16847.1 - 4.3e-05 23.5 0.8 9.9e-05 22.4 0.6 1.7 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_CXXC_CXXC) MoaC PF01967.16 AIC16847.1 - 0.04 13.5 0.0 0.072 12.7 0.0 1.3 1 0 0 1 1 1 0 MoaC family DUF632 PF04782.7 AIC16847.1 - 0.041 12.9 0.4 4.9 6.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF632) DUF1451 PF07295.6 AIC16847.1 - 0.15 11.7 0.6 0.32 10.7 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1451) Cas_Cas6 PF01881.11 AIC16848.1 - 4.2e-23 82.2 0.0 1.1e-22 80.9 0.0 1.6 2 0 0 2 2 2 1 CRISPR associated protein Cas6 Cas_Cas4 PF01930.12 AIC16849.1 - 1.2e-56 191.1 1.0 1.4e-56 190.9 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.2 AIC16849.1 - 7.7e-07 28.7 1.2 4.1e-06 26.3 0.2 1.9 2 0 0 2 2 2 1 PD-(D/E)XK nuclease superfamily PDDEXK_3 PF13366.1 AIC16849.1 - 0.012 15.6 0.7 0.022 14.7 0.5 1.6 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily Cas_Cas1 PF01867.11 AIC16850.1 - 9e-92 307.1 0.4 1e-91 306.9 0.3 1.0 1 0 0 1 1 1 1 CRISPR associated protein Cas1 Talin_middle PF09141.5 AIC16850.1 - 0.088 12.4 0.1 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Talin, middle domain CRISPR_Cas2 PF09827.4 AIC16851.1 - 1.9e-18 66.3 0.1 2.2e-18 66.1 0.0 1.0 1 0 0 1 1 1 1 CRISPR associated protein Cas2 Poxvirus PF06227.7 AIC16851.1 - 0.041 13.4 0.1 0.073 12.6 0.0 1.4 1 1 0 1 1 1 0 dsDNA Poxvirus NUDIX PF00293.23 AIC16852.1 - 4.6e-13 48.9 0.0 6.6e-13 48.4 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Usp PF00582.21 AIC16854.1 - 1.6e-08 34.8 0.0 1.7e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family AP_endonuc_2 PF01261.19 AIC16854.1 - 0.11 11.7 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel Usp PF00582.21 AIC16855.1 - 1.4e-17 64.1 0.1 1.7e-17 63.9 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family DUF4396 PF14342.1 AIC16856.1 - 0.015 15.3 0.0 0.017 15.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4396) MLANA PF14991.1 AIC16856.1 - 0.14 12.1 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein melan-A zf-Sec23_Sec24 PF04810.10 AIC16857.1 - 0.00023 20.6 4.0 0.0005 19.5 2.8 1.5 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger zf-HIT PF04438.11 AIC16857.1 - 0.002 17.7 7.3 0.0039 16.8 1.9 2.2 2 0 0 2 2 2 1 HIT zinc finger zinc-ribbons_6 PF07191.7 AIC16857.1 - 0.033 13.9 6.0 1.2 8.9 0.8 2.0 1 1 1 2 2 2 0 zinc-ribbons DZR PF12773.2 AIC16857.1 - 0.034 13.9 6.8 0.31 10.9 4.7 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-C3HC4_3 PF13920.1 AIC16857.1 - 0.057 13.1 1.8 0.057 13.1 1.2 2.4 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF164 PF02591.10 AIC16857.1 - 0.13 12.0 4.6 0.21 11.4 3.2 1.3 1 0 0 1 1 1 0 Putative zinc ribbon domain DUF35_N PF12172.3 AIC16857.1 - 0.14 12.1 4.5 0.25 11.2 0.8 2.1 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DUF2387 PF09526.5 AIC16857.1 - 0.14 12.0 0.2 0.14 12.0 0.1 2.2 2 1 1 3 3 3 0 Probable metal-binding protein (DUF2387) zf-FPG_IleRS PF06827.9 AIC16857.1 - 0.35 10.5 6.9 4.9 6.8 0.7 2.8 2 1 0 2 2 2 0 Zinc finger found in FPG and IleRS Opy2 PF09463.5 AIC16857.1 - 0.46 10.6 5.3 1 9.5 1.4 2.2 2 0 0 2 2 2 0 Opy2 protein PolC_DP2 PF03833.8 AIC16857.1 - 0.77 7.3 4.3 0.78 7.3 3.0 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-ribbon_3 PF13248.1 AIC16857.1 - 0.95 8.7 7.2 6.6 6.0 0.3 2.6 1 1 2 3 3 3 0 zinc-ribbon domain FYVE_2 PF02318.11 AIC16857.1 - 0.98 9.3 5.1 1.2 8.9 3.6 1.2 1 0 0 1 1 1 0 FYVE-type zinc finger zinc_ribbon_5 PF13719.1 AIC16857.1 - 1.2 8.7 4.9 22 4.7 0.0 3.2 3 0 0 3 3 3 0 zinc-ribbon domain zf-MIZ PF02891.15 AIC16857.1 - 1.7 8.1 7.7 20 4.7 4.6 2.4 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger ZZ PF00569.12 AIC16857.1 - 3.4 7.2 6.7 23 4.6 4.6 2.0 1 1 0 1 1 1 0 Zinc finger, ZZ type HypA PF01155.14 AIC16857.1 - 3.6 7.3 5.6 5.6 6.6 3.9 1.5 1 1 0 1 1 1 0 Hydrogenase expression/synthesis hypA family zf-MYND PF01753.13 AIC16857.1 - 4.1 7.3 7.8 24 4.9 5.0 2.2 1 1 0 1 1 1 0 MYND finger C1_1 PF00130.17 AIC16857.1 - 5.4 6.8 8.6 29 4.5 6.0 2.2 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RecR PF02132.10 AIC16857.1 - 5.9 6.4 7.4 5.5 6.5 1.5 2.2 2 0 0 2 2 2 0 RecR protein Ribosomal_L32p PF01783.18 AIC16857.1 - 6.2 7.0 7.3 3.4 7.9 0.6 2.1 1 1 1 2 2 2 0 Ribosomal L32p protein family zf-RING-like PF08746.6 AIC16857.1 - 7.2 6.7 9.8 0.58 10.2 3.1 1.8 2 0 0 2 2 2 0 RING-like domain zf-B_box PF00643.19 AIC16857.1 - 9.3 6.2 9.0 37 4.3 6.2 2.1 1 1 0 1 1 1 0 B-box zinc finger IncA PF04156.9 AIC16858.1 - 0.038 13.5 2.2 0.16 11.5 0.0 2.0 2 0 0 2 2 2 0 IncA protein DUF4097 PF13349.1 AIC16858.1 - 0.064 12.7 0.3 6 6.3 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4097) YtpI PF14007.1 AIC16858.1 - 2.4 8.1 5.1 8.8 6.3 0.1 2.2 2 0 0 2 2 2 0 YtpI-like protein OAD_gamma PF04277.8 AIC16858.1 - 6.7 7.1 6.2 0.24 11.8 0.4 1.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain MTHFR PF02219.12 AIC16859.1 - 0.006 15.7 0.0 0.011 14.8 0.0 1.5 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase DUF2387 PF09526.5 AIC16860.1 - 0.0073 16.2 0.3 0.0073 16.2 0.2 2.1 2 0 0 2 2 2 1 Probable metal-binding protein (DUF2387) Ribosomal_L37ae PF01780.14 AIC16860.1 - 0.035 13.9 3.9 0.06 13.2 2.7 1.5 1 1 0 1 1 1 0 Ribosomal L37ae protein family Toxin_17 PF08086.6 AIC16860.1 - 0.077 13.0 2.0 0.077 13.0 1.4 2.0 3 0 0 3 3 2 0 Ergtoxin family LRV_FeS PF05484.6 AIC16860.1 - 0.23 11.0 0.0 0.23 11.0 0.0 2.7 3 1 0 3 3 3 0 LRV protein FeS4 cluster Rep_fac-A_C PF08646.5 AIC16860.1 - 0.32 10.6 5.0 0.49 10.0 3.4 1.4 1 0 0 1 1 1 0 Replication factor-A C terminal domain zinc_ribbon_5 PF13719.1 AIC16860.1 - 0.37 10.4 0.1 0.37 10.4 0.1 3.0 4 0 0 4 4 4 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC16860.1 - 0.63 9.7 0.1 0.63 9.7 0.1 3.0 4 0 0 4 4 4 0 zinc-ribbon domain Clusterin PF01093.12 AIC16860.1 - 0.64 8.7 3.8 0.69 8.6 2.6 1.1 1 0 0 1 1 1 0 Clusterin C1_1 PF00130.17 AIC16860.1 - 0.82 9.4 10.6 2.1 8.1 0.2 3.2 1 1 2 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Tnp_zf-ribbon_2 PF13842.1 AIC16860.1 - 1.4 9.3 13.3 0.64 10.4 2.7 3.1 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon DZR PF12773.2 AIC16860.1 - 1.6 8.6 9.6 1.3 8.9 1.5 2.6 2 2 0 2 2 2 0 Double zinc ribbon zf-C3HC4_3 PF13920.1 AIC16860.1 - 2 8.1 14.6 1.4 8.5 6.8 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DnaJ_CXXCXGXG PF00684.14 AIC16860.1 - 4.4 7.4 11.8 44 4.2 5.4 2.7 1 1 1 2 2 2 0 DnaJ central domain HypA PF01155.14 AIC16860.1 - 4.9 6.8 8.4 2.4 7.8 1.3 2.1 1 1 1 2 2 2 0 Hydrogenase expression/synthesis hypA family Cys_rich_KTR PF14205.1 AIC16860.1 - 7.6 6.0 9.8 48 3.5 3.5 3.2 3 1 0 3 3 3 0 Cysteine-rich KTR zf-HIT PF04438.11 AIC16860.1 - 9.1 6.0 15.1 9.7 5.9 0.2 3.7 3 1 0 3 3 3 0 HIT zinc finger ABC_tran PF00005.22 AIC16861.1 - 5.9e-32 110.8 0.0 8.3e-32 110.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC16861.1 - 2e-10 41.1 0.0 0.00061 19.8 0.0 2.1 1 1 1 2 2 2 2 AAA domain AAA_16 PF13191.1 AIC16861.1 - 7.4e-06 26.0 0.1 1.5e-05 25.0 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 AIC16861.1 - 1.4e-05 24.3 0.0 1.8e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_15 PF13175.1 AIC16861.1 - 2.6e-05 23.4 0.0 0.17 10.8 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain SMC_N PF02463.14 AIC16861.1 - 4.9e-05 22.6 2.1 0.012 14.8 0.0 2.6 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA PF00004.24 AIC16861.1 - 0.00021 21.4 0.9 0.0028 17.8 0.6 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.1 AIC16861.1 - 0.00065 20.5 0.3 0.0012 19.6 0.2 1.9 1 1 0 1 1 1 1 AAA domain ABC_ATPase PF09818.4 AIC16861.1 - 0.0014 17.3 0.1 0.046 12.3 0.0 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_28 PF13521.1 AIC16861.1 - 0.0014 18.6 0.0 0.0032 17.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AIC16861.1 - 0.0017 18.6 0.0 0.0031 17.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.12 AIC16861.1 - 0.002 17.5 0.5 0.039 13.3 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.1 AIC16861.1 - 0.0024 17.9 0.1 0.0091 16.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.9 AIC16861.1 - 0.0036 17.0 0.1 0.014 15.1 0.0 2.0 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.1 AIC16861.1 - 0.0041 16.5 0.0 0.0072 15.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain Arch_ATPase PF01637.13 AIC16861.1 - 0.0048 16.6 0.0 0.011 15.4 0.0 1.8 1 1 0 1 1 1 1 Archaeal ATPase NACHT PF05729.7 AIC16861.1 - 0.0093 15.6 0.0 0.018 14.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Rad17 PF03215.10 AIC16861.1 - 0.012 14.2 0.0 0.019 13.6 0.0 1.2 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein AAA_29 PF13555.1 AIC16861.1 - 0.015 14.8 0.0 0.03 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.1 AIC16861.1 - 0.017 14.7 0.0 0.036 13.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.20 AIC16861.1 - 0.022 14.2 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain MMR_HSR1 PF01926.18 AIC16861.1 - 0.023 14.6 0.0 0.093 12.6 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.1 AIC16861.1 - 0.027 14.8 0.2 0.044 14.1 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_19 PF13245.1 AIC16861.1 - 0.029 14.0 0.0 0.079 12.7 0.0 1.8 1 0 0 1 1 1 0 Part of AAA domain Mg_chelatase PF01078.16 AIC16861.1 - 0.032 13.3 0.1 0.23 10.5 0.0 2.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.4 AIC16861.1 - 0.033 13.6 0.0 0.063 12.7 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.10 AIC16861.1 - 0.034 13.9 0.0 0.12 12.2 0.0 2.0 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit RNA_helicase PF00910.17 AIC16861.1 - 0.035 14.2 0.0 0.11 12.6 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_33 PF13671.1 AIC16861.1 - 0.036 13.9 0.0 0.071 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.17 AIC16861.1 - 0.036 12.9 0.0 0.056 12.3 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_14 PF13173.1 AIC16861.1 - 0.038 13.8 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain Miro PF08477.8 AIC16861.1 - 0.062 13.7 0.0 0.13 12.7 0.0 1.5 1 0 0 1 1 1 0 Miro-like protein AAA_10 PF12846.2 AIC16861.1 - 0.073 12.4 0.5 0.25 10.7 0.0 1.9 1 1 1 2 2 2 0 AAA-like domain SbcCD_C PF13558.1 AIC16861.1 - 0.077 12.9 0.4 0.38 10.7 0.3 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit FeoB_N PF02421.13 AIC16861.1 - 0.092 12.0 0.0 0.2 10.9 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B MobB PF03205.9 AIC16861.1 - 0.098 12.3 0.1 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B UPF0079 PF02367.12 AIC16861.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 PhoH PF02562.11 AIC16861.1 - 0.11 11.6 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Phytochelatin PF05023.9 AIC16861.1 - 0.13 11.2 0.0 0.19 10.6 0.0 1.3 1 0 0 1 1 1 0 Phytochelatin synthase Neurensin PF14927.1 AIC16862.1 - 0.0025 17.1 0.1 0.23 10.8 0.0 2.2 2 0 0 2 2 2 2 Neurensin DUF4077 PF13295.1 AIC16862.1 - 0.0036 17.0 0.2 0.58 9.8 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4077) IncA PF04156.9 AIC16862.1 - 0.017 14.7 0.8 0.29 10.6 0.2 2.1 2 0 0 2 2 2 0 IncA protein DUF2562 PF10814.3 AIC16862.1 - 0.03 14.2 1.5 0.21 11.5 0.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF2562) DUF3098 PF11297.3 AIC16862.1 - 0.086 12.5 0.7 9.7 5.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) DUF11 PF01345.13 AIC16862.1 - 0.094 12.7 0.3 0.34 10.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF11 Pterin_bind PF00809.17 AIC16863.1 - 2.9e-25 88.8 0.0 7e-25 87.6 0.0 1.7 1 0 0 1 1 1 1 Pterin binding enzyme B12-binding PF02310.14 AIC16863.1 - 8.4e-20 70.8 0.1 4.2e-19 68.5 0.0 2.3 2 1 1 3 3 3 1 B12 binding domain Met_synt_B12 PF02965.12 AIC16863.1 - 4.6e-19 68.4 0.0 8.6e-19 67.5 0.0 1.5 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain B12-binding_2 PF02607.12 AIC16863.1 - 3.3e-16 59.0 0.1 1.1e-15 57.4 0.1 1.9 1 0 0 1 1 1 1 B12 binding domain CdhD PF03599.11 AIC16863.1 - 0.0011 17.5 0.0 0.0022 16.5 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit Pterin_4a PF01329.14 AIC16864.1 - 4.7e-24 83.9 0.0 7.8e-24 83.2 0.0 1.3 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase RskA PF10099.4 AIC16864.1 - 0.058 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Anti-sigma-K factor rskA S-methyl_trans PF02574.11 AIC16867.1 - 1.1e-70 238.3 0.0 1.4e-70 238.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase VirionAssem_T7 PF11653.3 AIC16868.1 - 0.0032 18.2 3.3 0.0058 17.3 2.3 1.5 1 0 0 1 1 1 1 Bacteriophage T7 virion assembly protein Alba PF01918.16 AIC16868.1 - 0.022 14.3 0.5 0.067 12.7 0.2 1.9 1 1 1 2 2 2 0 Alba CoA_binding_3 PF13727.1 AIC16869.1 - 1.6 8.4 4.6 0.47 10.2 0.8 1.7 1 1 1 2 2 2 0 CoA-binding domain LTD PF00932.14 AIC16870.1 - 0.013 15.5 0.0 0.04 14.0 0.0 1.8 1 0 0 1 1 1 0 Lamin Tail Domain NHL PF01436.16 AIC16871.1 - 3.2e-10 39.4 15.3 0.0031 17.3 0.0 6.6 6 1 1 7 7 7 2 NHL repeat Arylesterase PF01731.15 AIC16871.1 - 3.3e-05 23.8 1.8 0.83 9.6 0.0 4.7 3 1 1 4 4 4 2 Arylesterase SGL PF08450.7 AIC16871.1 - 0.0019 17.6 0.2 0.44 9.8 0.0 3.0 1 1 2 3 3 3 1 SMP-30/Gluconolaconase/LRE-like region Coatomer_WDAD PF04053.9 AIC16871.1 - 0.016 14.0 0.0 0.12 11.1 0.0 2.0 2 0 0 2 2 2 0 Coatomer WD associated region Me-amine-dh_H PF06433.6 AIC16871.1 - 0.016 13.8 0.2 0.15 10.6 0.1 2.4 2 1 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.11 AIC16871.1 - 0.066 11.5 1.9 6 5.0 0.1 3.3 2 1 1 4 4 4 0 Cytochrome D1 heme domain DUF1236 PF06823.7 AIC16871.1 - 0.21 11.3 7.0 0.46 10.2 0.1 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF1236) PQQ_3 PF13570.1 AIC16871.1 - 5.1 7.4 10.0 1.4 9.3 0.3 4.3 5 0 0 5 5 5 0 PQQ-like domain tRNA-synt_2 PF00152.15 AIC16872.1 - 7.8e-77 258.2 0.0 9.3e-77 258.0 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.20 AIC16872.1 - 8.5e-11 41.5 0.1 1.6e-10 40.6 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti-like PF12869.2 AIC16872.1 - 0.00014 21.3 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 tRNA_anti-like tRNA-synt_2d PF01409.15 AIC16872.1 - 0.072 12.2 0.0 1.2 8.2 0.0 2.6 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) TetR_N PF00440.18 AIC16873.1 - 1e-15 57.0 0.0 1.9e-15 56.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.1 AIC16873.1 - 1.4e-09 37.9 0.3 2.4e-09 37.2 0.1 1.5 2 0 0 2 2 2 1 Bacterial transcriptional repressor WHG PF13305.1 AIC16873.1 - 0.011 16.2 0.1 0.032 14.8 0.0 1.8 2 0 0 2 2 2 0 WHG domain LacI PF00356.16 AIC16873.1 - 0.13 11.8 0.0 0.35 10.5 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family FtsX PF02687.16 AIC16874.1 - 0.12 12.1 8.0 0.14 11.9 5.6 1.0 1 0 0 1 1 1 0 FtsX-like permease family Git3 PF11710.3 AIC16874.1 - 0.47 9.9 5.2 0.52 9.8 3.6 1.1 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 MgtC PF02308.11 AIC16875.1 - 5.6e-28 97.4 5.6 7.3e-28 97.0 3.9 1.1 1 0 0 1 1 1 1 MgtC family EI24 PF07264.6 AIC16875.1 - 0.061 12.7 0.9 0.1 12.0 0.6 1.5 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Chromate_transp PF02417.10 AIC16875.1 - 0.097 12.2 5.9 0.13 11.8 4.1 1.2 1 0 0 1 1 1 0 Chromate transporter DUF2721 PF11026.3 AIC16875.1 - 1.6 8.3 4.7 1.6 8.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) AA_permease_C PF13906.1 AIC16875.1 - 4.3 7.2 5.9 1.8 8.4 0.6 2.8 3 0 0 3 3 3 0 C-terminus of AA_permease 7TM-7TMR_HD PF07698.6 AIC16875.1 - 5.4 6.4 9.2 0.83 9.0 0.9 2.0 1 1 1 2 2 2 0 7TM receptor with intracellular HD hydrolase MelC1 PF06236.6 AIC16876.1 - 0.047 13.6 0.2 0.067 13.1 0.1 1.3 1 0 0 1 1 1 0 Tyrosinase co-factor MelC1 DUF2611 PF11022.3 AIC16876.1 - 0.12 12.4 0.8 5.9 7.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2611) TrmB PF01978.14 AIC16877.1 - 0.00052 19.6 0.4 0.0012 18.4 0.0 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB LexA_DNA_bind PF01726.11 AIC16877.1 - 0.0033 16.9 0.0 0.0083 15.6 0.0 1.6 1 0 0 1 1 1 1 LexA DNA binding domain EII-Sor PF03609.9 AIC16877.1 - 0.0036 16.5 0.1 0.0051 16.1 0.1 1.2 1 0 0 1 1 1 1 PTS system sorbose-specific iic component HTH_27 PF13463.1 AIC16877.1 - 0.058 13.7 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain NUDIX PF00293.23 AIC16878.1 - 3.7e-21 75.1 0.0 6.7e-21 74.3 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain ADH_N PF08240.7 AIC16879.1 - 2.1e-28 98.2 2.2 2.1e-28 98.2 1.5 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.21 AIC16879.1 - 1e-20 73.5 1.5 1.9e-20 72.7 1.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.14 AIC16879.1 - 0.00016 20.8 0.1 0.00028 20.1 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.16 AIC16879.1 - 0.00034 20.2 0.3 0.0007 19.1 0.2 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.16 AIC16879.1 - 0.005 16.4 0.3 0.008 15.7 0.2 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase CoA_binding PF02629.14 AIC16879.1 - 0.013 15.9 0.9 0.034 14.6 0.6 1.7 1 0 0 1 1 1 0 CoA binding domain Methyltransf_11 PF08241.7 AIC16879.1 - 0.016 15.6 0.2 0.11 12.9 0.2 2.2 1 1 0 1 1 1 0 Methyltransferase domain AP_endonuc_2 PF01261.19 AIC16879.1 - 0.034 13.4 0.0 0.1 11.8 0.0 1.7 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel ApbA PF02558.11 AIC16879.1 - 0.11 11.9 0.2 0.19 11.1 0.2 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CitMHS PF03600.11 AIC16880.1 - 3.9e-36 124.3 38.2 4.8e-36 124.0 18.8 2.1 2 0 0 2 2 2 2 Citrate transporter HEAT_2 PF13646.1 AIC16881.1 - 0.018 15.2 0.5 0.021 15.0 0.4 1.2 1 0 0 1 1 1 0 HEAT repeats TPR_10 PF13374.1 AIC16881.1 - 0.17 11.8 1.3 0.19 11.7 0.1 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PEP-utilisers_N PF05524.8 AIC16882.1 - 0.11 12.3 1.3 0.15 11.8 0.9 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal DUF872 PF05915.7 AIC16883.1 - 0.022 14.5 1.2 0.024 14.4 0.8 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) DUF2178 PF09946.4 AIC16883.1 - 0.091 12.5 0.5 0.13 11.9 0.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) GLTT PF01744.15 AIC16883.1 - 0.14 11.6 0.7 0.27 10.6 0.5 1.5 1 0 0 1 1 1 0 GLTT repeat (6 copies) DUF1469 PF07332.6 AIC16883.1 - 0.19 11.4 3.6 0.23 11.2 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) DUF4199 PF13858.1 AIC16884.1 - 0.019 14.8 0.0 0.023 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Synaptobrevin PF00957.16 AIC16884.1 - 0.33 10.5 1.6 0.47 10.0 1.1 1.2 1 0 0 1 1 1 0 Synaptobrevin PGPGW PF09656.5 AIC16886.1 - 1.8 7.9 5.1 3.1 7.1 0.2 2.2 2 0 0 2 2 2 0 Putative transmembrane protein (PGPGW) PsbX PF06596.6 AIC16886.1 - 1.9 8.2 6.3 0.28 10.8 0.5 2.0 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) IF2_N PF04760.10 AIC16889.1 - 0.021 14.4 0.1 0.031 13.9 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region PHP_C PF13263.1 AIC16893.1 - 3.9e-10 39.0 0.0 6.6e-10 38.3 0.0 1.4 1 0 0 1 1 1 1 PHP-associated PHP PF02811.14 AIC16893.1 - 0.0045 16.7 0.0 0.0083 15.9 0.0 1.4 1 1 0 1 1 1 1 PHP domain TRAM PF01938.15 AIC16894.1 - 4.4e-14 51.9 3.0 5.1e-14 51.8 2.1 1.1 1 0 0 1 1 1 1 TRAM domain S1 PF00575.18 AIC16894.1 - 0.1 12.7 3.4 3.9 7.6 0.3 2.3 1 1 0 2 2 2 0 S1 RNA binding domain Isochorismatase PF00857.15 AIC16895.1 - 4.2e-42 144.0 0.0 5e-42 143.7 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family DDE_Tnp_IS240 PF13610.1 AIC16896.1 - 8.9e-10 38.6 0.0 1.4e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC16896.1 - 2.3e-05 24.4 0.2 4.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.9 AIC16896.1 - 0.00017 20.8 0.6 0.00033 19.9 0.3 1.6 1 1 0 1 1 1 1 Transposase IS66 family DUF4206 PF13901.1 AIC16896.1 - 0.029 13.9 0.7 0.04 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4206) zf-AN1 PF01428.11 AIC16898.1 - 2.3e-11 43.3 6.3 3.4e-11 42.8 4.3 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger Peptidase_M50 PF02163.17 AIC16898.1 - 1.8e-08 33.5 12.9 3.9e-07 29.2 9.0 2.3 1 1 0 1 1 1 1 Peptidase family M50 DUF2024 PF09630.5 AIC16899.1 - 1.2e-08 34.5 0.1 4.8e-08 32.5 0.1 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF2024) YfhD PF14151.1 AIC16899.1 - 0.11 12.6 0.1 0.19 11.8 0.1 1.2 1 0 0 1 1 1 0 YfhD-like protein Amidohydro_4 PF13147.1 AIC16900.1 - 0.053 13.5 0.0 0.064 13.2 0.0 1.3 1 0 0 1 1 1 0 Amidohydrolase Guanylate_cyc PF00211.15 AIC16902.1 - 8.6e-14 51.3 0.0 1.1e-13 50.9 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Response_reg PF00072.19 AIC16903.1 - 6.6e-21 74.4 0.2 7.4e-21 74.2 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.21 AIC16904.1 - 1.5e-25 89.0 0.0 3.6e-25 87.8 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.1 AIC16904.1 - 2.5e-20 72.8 0.0 7.7e-20 71.2 0.0 1.9 1 0 0 1 1 1 1 PAS domain HAMP PF00672.20 AIC16904.1 - 4.6e-17 61.9 0.1 4.6e-17 61.9 0.1 2.7 3 0 0 3 3 3 1 HAMP domain HisKA PF00512.20 AIC16904.1 - 3.6e-15 55.7 1.2 1.4e-14 53.8 0.0 2.7 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain PAS PF00989.19 AIC16904.1 - 4.7e-12 45.6 0.0 1.1e-11 44.4 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_3 PF08447.6 AIC16904.1 - 7.5e-11 41.9 0.0 1.6e-10 40.9 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.5 AIC16904.1 - 1.6e-09 37.7 0.0 3.6e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.1 AIC16904.1 - 0.012 15.5 0.0 0.041 13.7 0.0 1.9 1 0 0 1 1 1 0 PAS domain PAS_11 PF14598.1 AIC16904.1 - 0.027 14.4 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 PAS domain DUF2899 PF11449.3 AIC16904.1 - 0.061 12.5 0.0 0.6 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2899) Cache_3 PF14827.1 AIC16904.1 - 0.1 12.5 0.4 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 Sensory domain of two-component sensor kinase AA_permease_2 PF13520.1 AIC16905.1 - 5.2e-39 133.9 49.0 7.1e-39 133.5 34.0 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.16 AIC16905.1 - 2.2e-35 121.9 43.5 3e-35 121.5 30.2 1.1 1 0 0 1 1 1 1 Amino acid permease Usp PF00582.21 AIC16905.1 - 1.5e-08 34.9 0.5 0.00026 21.1 0.0 2.8 2 1 0 2 2 2 2 Universal stress protein family AA_permease_C PF13906.1 AIC16905.1 - 6.2e-06 25.9 6.5 6.2e-06 25.9 4.5 3.3 2 0 0 2 2 2 1 C-terminus of AA_permease MobB PF03205.9 AIC16906.1 - 8e-08 32.0 0.0 1.5e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_10 PF12846.2 AIC16906.1 - 0.0096 15.3 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain QueC PF06508.8 AIC16907.1 - 9.8e-46 155.6 0.0 1.1e-45 155.4 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.9 AIC16907.1 - 5.3e-07 29.2 0.0 0.00011 21.7 0.0 2.3 2 1 0 2 2 2 2 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.15 AIC16907.1 - 0.00017 21.1 0.1 0.0013 18.2 0.0 2.1 1 1 1 2 2 2 1 PP-loop family Asn_synthase PF00733.16 AIC16907.1 - 0.00093 18.7 0.0 0.0018 17.8 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_4 PF01902.12 AIC16907.1 - 0.008 15.5 0.0 0.015 14.7 0.0 1.4 1 1 0 1 1 1 1 ATP-binding region NAD_synthase PF02540.12 AIC16907.1 - 0.0082 15.0 0.0 0.028 13.3 0.0 1.7 2 0 0 2 2 2 1 NAD synthase PTPS PF01242.14 AIC16908.1 - 1.3e-18 66.8 0.0 2.5e-18 65.9 0.0 1.4 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase Ribonuclease_T2 PF00445.13 AIC16909.1 - 0.16 11.6 0.0 0.16 11.5 0.0 1.0 1 0 0 1 1 1 0 Ribonuclease T2 family Asn_synthase PF00733.16 AIC16910.1 - 8e-35 120.5 0.1 4.5e-34 118.1 0.1 1.8 1 1 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.12 AIC16910.1 - 1.7e-07 30.4 0.0 3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.8 AIC16910.1 - 3.4e-05 23.2 0.0 4.6e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.11 AIC16910.1 - 0.0027 16.3 0.1 0.0079 14.7 0.1 1.7 1 1 0 1 1 1 1 tRNA methyl transferase ATP_bind_3 PF01171.15 AIC16910.1 - 0.0037 16.7 0.1 0.0056 16.1 0.0 1.5 1 0 0 1 1 1 1 PP-loop family HTH_45 PF14947.1 AIC16911.1 - 0.0025 17.6 1.1 0.0027 17.4 0.2 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix Sulfolobus_pRN PF05584.6 AIC16911.1 - 0.003 17.4 0.1 0.0056 16.6 0.1 1.4 1 0 0 1 1 1 1 Sulfolobus plasmid regulatory protein Rad17 PF03215.10 AIC16911.1 - 0.052 12.2 0.2 0.059 12.0 0.1 1.0 1 0 0 1 1 1 0 Rad17 cell cycle checkpoint protein TrmB PF01978.14 AIC16911.1 - 0.068 12.8 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Rio2_N PF09202.6 AIC16911.1 - 0.092 12.8 0.1 0.29 11.2 0.0 1.8 2 0 0 2 2 2 0 Rio2, N-terminal HTH_27 PF13463.1 AIC16911.1 - 0.12 12.7 0.5 2.1 8.7 0.4 2.3 1 1 0 1 1 1 0 Winged helix DNA-binding domain YhzD PF14120.1 AIC16911.1 - 0.14 12.1 0.2 6.7 6.6 0.0 2.3 2 0 0 2 2 2 0 YhzD-like protein UbiA PF01040.13 AIC16912.1 - 1.1e-31 109.9 16.2 1.5e-31 109.6 11.0 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Lig_chan PF00060.21 AIC16912.1 - 1.7 8.3 4.5 16 5.2 0.0 2.6 2 0 0 2 2 2 0 Ligand-gated ion channel HTH_45 PF14947.1 AIC16913.1 - 0.00014 21.5 0.2 0.00033 20.4 0.2 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_20 PF12840.2 AIC16913.1 - 0.015 15.1 0.0 0.06 13.1 0.0 2.1 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_24 PF13412.1 AIC16913.1 - 0.078 12.3 0.2 0.84 9.0 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Abhydrolase_6 PF12697.2 AIC16914.1 - 2.3e-29 102.9 0.0 3.1e-29 102.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_5 PF12695.2 AIC16914.1 - 3.6e-21 75.4 0.0 5.5e-21 74.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.3 AIC16914.1 - 3.4e-12 46.0 0.1 6.2e-11 41.9 0.0 2.7 1 1 2 3 3 3 1 Putative lysophospholipase Abhydrolase_1 PF00561.15 AIC16914.1 - 1.3e-10 41.2 0.1 7.1e-09 35.5 0.0 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold DUF2305 PF10230.4 AIC16914.1 - 0.00016 21.1 0.2 0.00044 19.7 0.1 1.8 1 1 0 1 1 1 1 Uncharacterised conserved protein (DUF2305) DUF1057 PF06342.7 AIC16914.1 - 0.00034 19.5 0.0 0.00054 18.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) Peptidase_S9 PF00326.16 AIC16914.1 - 0.0017 17.6 0.0 0.0017 17.6 0.0 2.4 3 0 0 3 3 3 1 Prolyl oligopeptidase family DLH PF01738.13 AIC16914.1 - 0.004 16.4 0.0 0.045 13.0 0.0 2.2 2 0 0 2 2 2 1 Dienelactone hydrolase family DUF1749 PF08538.5 AIC16914.1 - 0.013 14.4 0.0 0.035 12.9 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1749) FSH1 PF03959.8 AIC16914.1 - 0.016 14.7 0.0 3.6 6.9 0.0 2.9 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Peptidase_S15 PF02129.13 AIC16914.1 - 0.028 13.8 0.0 5.7 6.2 0.0 2.1 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.8 AIC16914.1 - 0.028 13.9 0.0 0.05 13.1 0.0 1.5 1 1 0 1 1 1 0 alpha/beta hydrolase fold LCAT PF02450.10 AIC16914.1 - 0.072 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF900 PF05990.7 AIC16914.1 - 0.074 12.3 0.2 0.28 10.4 0.1 2.0 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) Ser_hydrolase PF06821.8 AIC16914.1 - 0.096 12.2 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase DUF3530 PF12048.3 AIC16914.1 - 0.15 11.0 0.0 3.8 6.4 0.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3530) Methyltransf_31 PF13847.1 AIC16915.1 - 3.1e-18 65.8 0.0 4.2e-18 65.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC16915.1 - 2.4e-14 53.5 0.0 4.2e-14 52.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC16915.1 - 3.8e-13 49.4 0.0 5.4e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC16915.1 - 1.7e-12 47.5 0.0 3.2e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC16915.1 - 2.2e-11 44.3 0.0 3.6e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC16915.1 - 1.7e-09 38.0 0.0 2.9e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC16915.1 - 1.5e-06 28.2 0.0 2.2e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.14 AIC16915.1 - 2.4e-05 23.9 0.0 4.1e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.13 AIC16915.1 - 2.4e-05 23.5 0.0 3.6e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family FtsJ PF01728.14 AIC16915.1 - 4.2e-05 23.6 0.0 7.5e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_9 PF08003.6 AIC16915.1 - 0.0019 16.9 0.0 0.003 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_24 PF13578.1 AIC16915.1 - 0.0019 18.9 0.0 0.0033 18.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 AIC16915.1 - 0.0027 16.7 0.0 0.004 16.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase GidB PF02527.10 AIC16915.1 - 0.015 14.4 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G GCD14 PF08704.5 AIC16915.1 - 0.036 13.5 0.1 0.072 12.5 0.0 1.4 1 1 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit MTS PF05175.9 AIC16915.1 - 0.048 13.0 0.0 0.07 12.5 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain CMAS PF02353.15 AIC16915.1 - 0.078 12.0 0.1 0.14 11.1 0.0 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase Auto_anti-p27 PF06677.7 AIC16916.1 - 0.035 13.8 1.2 0.47 10.2 0.3 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) zf-SNAP50_C PF12251.3 AIC16916.1 - 0.12 11.7 0.3 0.12 11.7 0.2 1.0 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal TK PF00265.13 AIC16916.1 - 0.42 10.1 2.0 0.27 10.7 0.1 1.6 1 1 1 2 2 2 0 Thymidine kinase PHO4 PF01384.15 AIC16917.1 - 5.4e-96 321.0 35.9 6.6e-96 320.7 24.9 1.1 1 0 0 1 1 1 1 Phosphate transporter family PhoU_div PF01865.11 AIC16918.1 - 3.1e-23 82.0 5.1 3.7e-23 81.8 3.5 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PMC2NT PF08066.7 AIC16918.1 - 0.025 14.8 0.5 0.17 12.2 0.0 2.4 1 1 1 2 2 2 0 PMC2NT (NUC016) domain zf-C2H2_4 PF13894.1 AIC16919.1 - 0.00021 21.3 2.1 0.016 15.4 0.6 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC16919.1 - 0.0042 17.3 2.1 0.012 15.9 0.4 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type DUF1644 PF07800.7 AIC16919.1 - 0.013 15.3 0.3 2.5 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) zf-C2H2_jaz PF12171.3 AIC16919.1 - 0.031 14.4 0.7 0.31 11.2 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding NigD PF12667.2 AIC16919.1 - 0.052 13.3 0.0 0.066 12.9 0.0 1.1 1 0 0 1 1 1 0 NigD-like protein zf-met2 PF12907.2 AIC16919.1 - 0.064 13.2 1.0 0.084 12.8 0.1 1.7 2 0 0 2 2 2 0 Zinc-binding zf-DBF PF07535.7 AIC16919.1 - 0.28 10.9 1.4 10 5.8 0.1 2.3 2 0 0 2 2 2 0 DBF zinc finger zf-H2C2_5 PF13909.1 AIC16919.1 - 0.4 11.0 2.7 2.7 8.3 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain BNR PF02012.15 AIC16921.1 - 0.006 16.2 22.4 1.6 8.8 0.6 5.8 4 0 0 4 4 4 4 BNR/Asp-box repeat DUF1510 PF07423.6 AIC16921.1 - 0.03 13.6 5.8 0.06 12.6 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1510) SpoIIIAH PF12685.2 AIC16921.1 - 0.19 11.1 9.6 0.36 10.2 6.6 1.5 1 0 0 1 1 1 0 SpoIIIAH-like protein NST1 PF13945.1 AIC16921.1 - 1.7 8.6 8.5 2.8 7.9 5.9 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator TrmB PF01978.14 AIC16922.1 - 0.00011 21.8 0.1 0.00015 21.4 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_45 PF14947.1 AIC16922.1 - 0.00029 20.5 0.1 0.00038 20.1 0.1 1.3 1 1 0 1 1 1 1 Winged helix-turn-helix HTH_24 PF13412.1 AIC16922.1 - 0.00035 19.9 0.0 0.00052 19.3 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.2 AIC16922.1 - 0.002 17.7 0.2 0.0031 17.1 0.2 1.3 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.1 AIC16922.1 - 0.0042 17.0 0.1 0.0055 16.7 0.0 1.1 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.17 AIC16922.1 - 0.0057 16.3 0.1 0.0093 15.6 0.1 1.3 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.1 AIC16922.1 - 0.0062 16.3 0.2 0.0083 15.8 0.1 1.2 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Penicillinase_R PF03965.11 AIC16922.1 - 0.015 15.3 0.2 0.022 14.8 0.1 1.3 1 0 0 1 1 1 0 Penicillinase repressor S10_plectin PF03501.10 AIC16922.1 - 0.037 13.8 0.0 0.051 13.4 0.0 1.3 1 1 0 1 1 1 0 Plectin/S10 domain Rrf2 PF02082.15 AIC16922.1 - 0.063 13.3 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator Cdc6_C PF09079.6 AIC16922.1 - 0.081 12.6 0.2 0.11 12.2 0.1 1.4 1 1 0 1 1 1 0 CDC6, C terminal YcfA PF07927.7 AIC16922.1 - 0.12 12.2 0.1 0.27 11.1 0.0 1.6 2 0 0 2 2 2 0 YcfA-like protein TFIIE_alpha PF02002.12 AIC16922.1 - 0.13 11.8 0.1 0.16 11.5 0.0 1.1 1 0 0 1 1 1 0 TFIIE alpha subunit NOC3p PF07540.6 AIC16922.1 - 0.14 12.4 0.0 0.23 11.7 0.0 1.3 1 0 0 1 1 1 0 Nucleolar complex-associated protein DUF308 PF03729.8 AIC16924.1 - 0.012 15.5 0.1 0.024 14.6 0.1 1.5 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) DUF4366 PF14283.1 AIC16924.1 - 0.044 13.1 0.0 0.049 13.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) BON PF04972.12 AIC16925.1 - 0.064 13.0 0.1 0.088 12.5 0.1 1.2 1 0 0 1 1 1 0 BON domain Defensin_beta_2 PF13841.1 AIC16926.1 - 0.035 14.4 1.7 0.21 11.9 0.0 2.1 2 0 0 2 2 2 0 Beta defensin DUF796 PF05638.7 AIC16927.1 - 1.1e-40 138.7 0.0 1.4e-40 138.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF796) DUF1628 PF07790.6 AIC16927.1 - 0.03 15.0 0.5 0.073 13.8 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1628) SSURE PF11966.3 AIC16927.1 - 0.085 12.4 0.1 0.3 10.7 0.0 1.9 2 1 0 2 2 2 0 Fibronectin-binding repeat Vma12 PF11712.3 AIC16927.1 - 0.13 11.9 0.1 0.21 11.3 0.1 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase YopD PF05844.7 AIC16927.1 - 0.25 10.3 2.8 0.41 9.6 1.9 1.2 1 0 0 1 1 1 0 YopD protein FAD_binding_4 PF01565.18 AIC16929.1 - 0.035 13.5 0.2 0.068 12.6 0.1 1.5 1 1 1 2 2 2 0 FAD binding domain DUF2977 PF11192.3 AIC16930.1 - 0.014 15.2 0.0 0.032 14.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2977) rve_3 PF13683.1 AIC16931.1 - 0.059 12.8 0.0 0.14 11.7 0.0 1.9 1 1 0 1 1 1 0 Integrase core domain DUF72 PF01904.13 AIC16932.1 - 5.2e-61 206.3 0.0 6.6e-61 205.9 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 Mob_synth_C PF06463.8 AIC16934.1 - 0.06 13.0 3.2 0.1 12.2 2.2 1.4 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C SPO22 PF08631.5 AIC16935.1 - 0.023 13.7 0.1 0.031 13.3 0.0 1.1 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF1569 PF07606.6 AIC16935.1 - 0.08 12.8 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1569) DUF1759 PF03564.10 AIC16935.1 - 0.1 12.4 0.3 0.17 11.6 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) I_LWEQ PF01608.12 AIC16935.1 - 0.18 11.7 1.4 0.38 10.6 0.0 1.9 2 0 0 2 2 2 0 I/LWEQ domain AAA_22 PF13401.1 AIC16936.1 - 0.00074 19.6 0.0 0.0025 17.9 0.0 1.8 2 0 0 2 2 2 1 AAA domain DEAD PF00270.24 AIC16936.1 - 0.011 15.2 0.0 0.028 13.9 0.0 1.6 1 1 0 1 1 1 0 DEAD/DEAH box helicase DUF3038 PF11237.3 AIC16937.1 - 0.074 12.8 0.1 0.084 12.6 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) Surf_Ag_VNR PF07244.10 AIC16937.1 - 0.12 12.8 0.0 0.14 12.6 0.0 1.2 1 0 0 1 1 1 0 Surface antigen variable number repeat ABC_sub_bind PF04392.7 AIC16937.1 - 0.14 11.1 0.0 0.14 11.0 0.0 1.0 1 0 0 1 1 1 0 ABC transporter substrate binding protein RelA_SpoT PF04607.12 AIC16940.1 - 8.5e-22 77.3 0.6 2e-21 76.1 0.4 1.6 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins GrpE PF01025.14 AIC16940.1 - 0.01 15.3 3.5 1.3 8.5 0.3 2.2 2 0 0 2 2 2 0 GrpE TACC PF05010.9 AIC16940.1 - 0.016 14.9 1.8 0.032 13.9 1.3 1.6 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC) DUF869 PF05911.6 AIC16940.1 - 0.031 12.5 2.8 0.043 12.0 1.9 1.3 1 1 0 1 1 1 0 Plant protein of unknown function (DUF869) Muted PF14942.1 AIC16940.1 - 0.13 12.1 1.9 0.77 9.6 0.1 2.3 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein ING PF12998.2 AIC16945.1 - 0.016 15.4 0.0 0.02 15.1 0.0 1.1 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Tup_N PF08581.5 AIC16945.1 - 0.14 12.4 0.4 0.16 12.1 0.3 1.2 1 0 0 1 1 1 0 Tup N-terminal NADH-u_ox-rdase PF10785.4 AIC16946.1 - 0.068 13.4 0.3 0.083 13.1 0.2 1.1 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase complex I, 21 kDa subunit DUF872 PF05915.7 AIC16946.1 - 0.14 12.0 0.2 0.16 11.8 0.1 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF872) MTTB PF06253.6 AIC16946.1 - 0.36 8.5 1.6 0.38 8.4 1.1 1.0 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) DUF1469 PF07332.6 AIC16946.1 - 0.7 9.6 6.8 0.85 9.3 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1469) LIM PF00412.17 AIC16947.1 - 0.025 14.6 0.2 0.066 13.2 0.1 1.7 1 0 0 1 1 1 0 LIM domain TF_Zn_Ribbon PF08271.7 AIC16947.1 - 0.14 11.4 6.7 0.86 8.9 2.6 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding DUF4110 PF13422.1 AIC16952.1 - 0.019 14.7 0.2 0.055 13.3 0.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4110) HK97-gp10_like PF04883.7 AIC16954.1 - 0.00045 21.1 0.0 0.00061 20.6 0.0 1.2 1 0 0 1 1 1 1 Bacteriophage HK97-gp10, putative tail-component Toxin_51 PF15531.1 AIC16955.1 - 0.0091 15.7 0.8 0.034 13.9 0.0 2.3 2 0 0 2 2 2 1 Putative toxin 51 V-SNARE_C PF12352.3 AIC16955.1 - 0.014 15.4 3.8 2.2 8.4 0.1 2.9 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus HTH_31 PF13560.1 AIC16955.1 - 0.055 13.6 0.1 0.14 12.3 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain DUF2130 PF09903.4 AIC16955.1 - 0.26 9.9 14.0 0.07 11.8 0.7 3.4 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2130) DUF1664 PF07889.7 AIC16955.1 - 0.93 9.2 10.5 0.88 9.3 0.3 4.2 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) Rootletin PF15035.1 AIC16955.1 - 3.1 7.7 14.7 4.8 7.1 3.9 3.4 3 1 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion Baculo_PEP_C PF04513.7 AIC16955.1 - 4.6 7.0 11.4 1.1 9.1 0.2 3.8 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus HSBP1 PF06825.7 AIC16955.1 - 5.9 6.5 10.7 0.49 9.9 1.9 3.1 3 1 0 3 3 3 0 Heat shock factor binding protein 1 Presenilin PF01080.12 AIC16955.1 - 6.4 5.4 6.3 0.64 8.7 0.1 2.2 2 0 0 2 2 2 0 Presenilin zinc_ribbon_2 PF13240.1 AIC16956.1 - 7.7e-11 41.1 16.8 8e-07 28.3 1.9 2.3 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.2 AIC16956.1 - 9.4e-10 38.1 15.2 1.4e-09 37.5 10.5 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC16956.1 - 1.2e-08 33.9 19.9 0.0002 20.4 3.3 2.3 2 0 0 2 2 2 2 zinc-ribbon domain zf-RanBP PF00641.13 AIC16956.1 - 0.0096 15.0 11.9 0.11 11.6 1.1 2.2 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF2321 PF10083.4 AIC16956.1 - 0.057 12.9 6.0 0.32 10.4 2.6 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) zf-B_box PF00643.19 AIC16956.1 - 0.16 11.8 4.0 2.8 7.9 1.7 2.3 1 1 1 2 2 2 0 B-box zinc finger Cript PF10235.4 AIC16956.1 - 0.68 10.3 6.0 0.45 10.9 0.7 2.2 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT Nudix_N_2 PF14803.1 AIC16956.1 - 1.6 8.4 16.6 1.3 8.8 0.2 4.0 4 0 0 4 4 4 0 Nudix N-terminal A2L_zn_ribbon PF08792.5 AIC16956.1 - 7.4 6.1 6.9 23 4.5 0.1 3.5 3 0 0 3 3 3 0 A2L zinc ribbon domain DUF3614 PF12267.3 AIC16958.1 - 0.15 12.3 2.4 8.9 6.5 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3614) DUF2917 PF11142.3 AIC16960.1 - 0.026 13.6 0.3 1.8 7.7 0.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2917) DUF3585 PF12130.3 AIC16962.1 - 0.0022 17.8 1.0 0.0028 17.4 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3585) DUF2458 PF10454.4 AIC16962.1 - 0.024 14.5 1.1 0.025 14.4 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2458) DUF2498 PF10692.4 AIC16962.1 - 0.025 14.2 0.2 0.038 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) DUF2710 PF10921.3 AIC16962.1 - 0.055 13.6 0.5 0.084 13.0 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2710) DUF2335 PF10097.4 AIC16962.1 - 0.098 12.2 2.0 8.9 6.0 0.4 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2335) TEX12 PF15219.1 AIC16962.1 - 0.11 12.4 0.3 0.13 12.2 0.2 1.1 1 0 0 1 1 1 0 Testis-expressed 12 DUF4446 PF14584.1 AIC16962.1 - 0.17 11.7 2.0 0.19 11.5 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Phage_DsbA PF11126.3 AIC16962.1 - 0.17 11.9 2.3 0.38 10.8 1.1 2.0 2 1 0 2 2 2 0 Transcriptional regulator DsbA Spidroin_MaSp PF11260.3 AIC16963.1 - 0.044 13.8 0.0 0.063 13.3 0.0 1.3 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 TP_methylase PF00590.15 AIC16966.1 - 2.4e-34 118.8 0.0 2.8e-34 118.6 0.0 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases GTP_EFTU_D4 PF14578.1 AIC16966.1 - 0.054 13.1 0.6 0.15 11.6 0.1 1.9 2 0 0 2 2 2 0 Elongation factor Tu domain 4 Cu-oxidase_3 PF07732.10 AIC16967.1 - 6.7e-26 90.3 3.8 3.9e-20 71.7 0.1 2.4 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.9 AIC16967.1 - 2.7e-24 85.2 8.4 5.3e-13 48.6 0.5 3.3 3 0 0 3 3 3 3 Multicopper oxidase Cupredoxin_1 PF13473.1 AIC16967.1 - 0.0087 15.9 0.0 2.5 8.0 0.0 3.1 2 1 1 3 3 3 2 Cupredoxin-like domain DUF4278 PF14105.1 AIC16968.1 - 0.097 12.6 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4278) PepSY PF03413.14 AIC16969.1 - 0.0071 16.9 0.1 0.013 16.1 0.1 1.4 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain PepSY PF03413.14 AIC16970.1 - 0.014 16.0 0.3 0.019 15.5 0.2 1.3 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF2106 PF09879.4 AIC16970.1 - 0.1 11.9 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) RskA PF10099.4 AIC16970.1 - 1.2 8.8 9.1 2.8 7.6 0.3 2.1 1 1 1 2 2 2 0 Anti-sigma-K factor rskA PepSY_2 PF13670.1 AIC16970.1 - 4.9 7.1 6.7 0.25 11.2 0.5 1.9 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain TPPK_C PF12555.3 AIC16971.1 - 0.019 14.6 1.6 0.032 13.9 1.1 1.3 1 0 0 1 1 1 0 Thiamine pyrophosphokinase C terminal PepSY PF03413.14 AIC16972.1 - 2.3e-06 28.1 0.7 0.012 16.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain DUF1147 PF06615.6 AIC16972.1 - 0.057 13.2 0.0 2.3 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) GRIM-19 PF06212.7 AIC16973.1 - 0.011 15.4 0.0 0.016 14.9 0.0 1.2 1 0 0 1 1 1 0 GRIM-19 protein YbjM PF11045.3 AIC16973.1 - 0.027 14.2 1.0 0.13 12.0 0.7 1.8 1 1 0 1 1 1 0 Putative inner membrane protein of Enterobacteriaceae DUF106 PF01956.11 AIC16973.1 - 0.094 12.2 0.1 0.68 9.4 0.0 1.9 2 0 0 2 2 2 0 Integral membrane protein DUF106 HTH_45 PF14947.1 AIC16974.1 - 7.9e-08 32.0 0.7 9.8e-08 31.7 0.5 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.17 AIC16974.1 - 1e-05 25.1 0.0 1.5e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC16974.1 - 0.001 18.7 0.1 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.1 AIC16974.1 - 0.0012 18.1 0.3 0.0021 17.3 0.1 1.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Toxin_64 PF15542.1 AIC16974.1 - 0.0026 18.2 0.1 0.0032 18.0 0.1 1.2 1 0 0 1 1 1 1 Putative toxin 64 DUF2250 PF10007.4 AIC16974.1 - 0.011 15.5 0.3 0.23 11.4 0.1 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_Crp_2 PF13545.1 AIC16974.1 - 0.088 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HxlR PF01638.12 AIC16974.1 - 0.089 12.4 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 HxlR-like helix-turn-helix DUF2680 PF10925.3 AIC16974.1 - 0.1 12.4 0.1 11 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) 7TM-7TMR_HD PF07698.6 AIC16975.1 - 0.014 14.8 5.5 0.017 14.5 3.8 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase UCR_Fe-S_N PF10399.4 AIC16975.1 - 3.3 6.9 7.2 0.23 10.6 0.5 2.3 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal ABC_tran PF00005.22 AIC16976.1 - 1.4e-35 122.5 0.0 2.2e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC16976.1 - 6.1e-14 52.6 0.6 5.3e-11 43.0 0.4 2.1 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 AIC16976.1 - 9e-08 31.6 0.2 0.0035 16.6 0.0 2.4 2 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 AIC16976.1 - 2.6e-07 30.0 0.3 7e-05 22.0 0.2 2.1 1 1 1 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 AIC16976.1 - 2.3e-05 23.8 0.1 4.7e-05 22.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_17 PF13207.1 AIC16976.1 - 4.6e-05 24.2 0.0 7.3e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.1 AIC16976.1 - 7.5e-05 22.7 0.1 9.1e-05 22.5 0.1 1.4 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 AIC16976.1 - 9.2e-05 21.6 0.1 0.00014 21.0 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_25 PF13481.1 AIC16976.1 - 0.00034 20.0 0.1 0.011 15.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_10 PF12846.2 AIC16976.1 - 0.00066 19.1 0.8 0.0038 16.7 0.4 2.2 1 1 0 2 2 2 1 AAA-like domain AAA_22 PF13401.1 AIC16976.1 - 0.001 19.1 2.0 0.0028 17.7 0.2 2.2 2 1 0 2 2 1 1 AAA domain AAA_23 PF13476.1 AIC16976.1 - 0.0044 17.3 0.2 0.0085 16.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.18 AIC16976.1 - 0.0047 16.8 0.8 0.0073 16.2 0.5 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_33 PF13671.1 AIC16976.1 - 0.0057 16.5 0.4 0.019 14.8 0.3 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AIC16976.1 - 0.0064 16.7 0.4 0.011 15.9 0.3 1.6 1 1 0 1 1 1 1 AAA domain MobB PF03205.9 AIC16976.1 - 0.0072 16.0 0.1 0.037 13.7 0.0 2.0 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 AIC16976.1 - 0.0094 15.3 0.0 0.056 12.8 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_30 PF13604.1 AIC16976.1 - 0.012 15.2 0.1 0.026 14.0 0.1 1.6 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.13 AIC16976.1 - 0.018 14.5 0.1 0.035 13.5 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family SRP54 PF00448.17 AIC16976.1 - 0.031 13.7 0.0 0.069 12.5 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_28 PF13521.1 AIC16976.1 - 0.04 13.8 0.1 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain cobW PF02492.14 AIC16976.1 - 0.063 12.7 0.1 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain ATP-synt_ab PF00006.20 AIC16976.1 - 0.068 12.6 0.3 0.11 11.9 0.2 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain NACHT PF05729.7 AIC16976.1 - 0.077 12.6 0.0 0.2 11.3 0.0 1.7 2 0 0 2 2 1 0 NACHT domain ABC_ATPase PF09818.4 AIC16976.1 - 0.1 11.1 0.0 0.9 8.0 0.1 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class G-alpha PF00503.15 AIC16976.1 - 0.11 11.1 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit Dynamin_N PF00350.18 AIC16976.1 - 0.12 12.2 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 Dynamin family AAA_24 PF13479.1 AIC16976.1 - 0.15 11.6 0.2 0.8 9.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain NPCBM_assoc PF10633.4 AIC16977.1 - 2.9e-06 27.2 7.5 0.41 10.7 0.1 5.1 4 0 0 4 4 4 2 NPCBM-associated, NEW3 domain of alpha-galactosidase Transglut_C PF00927.17 AIC16977.1 - 0.015 15.3 0.6 1.4 8.9 0.0 3.2 3 0 0 3 3 3 0 Transglutaminase family, C-terminal ig like domain TRAP_alpha PF03896.11 AIC16977.1 - 0.02 13.8 0.3 0.86 8.5 0.0 3.1 3 2 0 3 3 3 0 Translocon-associated protein (TRAP), alpha subunit DUF912 PF06024.7 AIC16977.1 - 0.02 14.9 0.1 0.056 13.5 0.1 1.7 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF912) CARDB PF07705.6 AIC16977.1 - 0.029 14.4 11.8 0.22 11.6 0.3 3.7 3 1 0 3 3 3 0 CARDB DUF4366 PF14283.1 AIC16977.1 - 0.066 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) TRAP_beta PF05753.9 AIC16977.1 - 0.18 10.9 3.1 4.8 6.3 0.0 3.8 4 0 0 4 4 4 0 Translocon-associated protein beta (TRAPB) DUF1049 PF06305.6 AIC16977.1 - 2.1 7.9 4.4 2.7 7.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) MacB_PCD PF12704.2 AIC16978.1 - 2.3e-27 96.0 3.8 2.3e-27 96.0 2.7 2.5 3 0 0 3 3 3 2 MacB-like periplasmic core domain FtsX PF02687.16 AIC16978.1 - 6.6e-23 80.7 7.9 6.6e-23 80.7 5.5 2.0 2 0 0 2 2 2 1 FtsX-like permease family AA_kinase PF00696.23 AIC16980.1 - 3e-54 184.1 0.7 3e-54 184.1 0.5 2.0 2 1 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.1 AIC16980.1 - 5.8e-22 76.9 2.1 6.5e-10 38.3 0.1 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.20 AIC16980.1 - 1.5e-21 75.4 0.5 5.8e-11 41.6 0.1 2.8 2 0 0 2 2 2 2 ACT domain ACT_6 PF13740.1 AIC16980.1 - 0.021 14.5 2.8 0.16 11.7 0.0 3.4 3 0 0 3 3 3 0 ACT domain LytR_C PF13399.1 AIC16980.1 - 0.043 14.2 0.1 1.1 9.7 0.0 2.5 1 1 1 2 2 2 0 LytR cell envelope-related transcriptional attenuator PCNA_N PF00705.13 AIC16981.1 - 4.7e-18 64.9 0.0 1.3e-16 60.2 0.0 2.1 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.10 AIC16981.1 - 9.5e-16 57.8 0.1 2.3e-14 53.4 0.0 2.5 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.11 AIC16981.1 - 8e-09 34.6 0.1 0.00031 19.6 0.0 2.1 1 1 0 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.8 AIC16981.1 - 0.00015 20.9 0.0 0.00021 20.5 0.0 1.1 1 0 0 1 1 1 1 Rad9 Cation_efflux PF01545.16 AIC16983.1 - 2.6e-46 158.0 6.4 3.1e-46 157.7 4.4 1.0 1 0 0 1 1 1 1 Cation efflux family ABA_WDS PF02496.11 AIC16983.1 - 0.12 12.5 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 ABA/WDS induced protein DUF3180 PF11377.3 AIC16983.1 - 6.2 6.6 8.1 0.22 11.3 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3180) GARS_A PF01071.14 AIC16984.1 - 8.2e-16 58.1 0.0 2.3e-15 56.6 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_C PF02843.11 AIC16984.1 - 1.4e-09 37.9 0.0 4.9e-09 36.2 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_4 PF13535.1 AIC16984.1 - 0.0001 22.1 0.0 0.00017 21.3 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain AsnC_trans_reg PF01037.16 AIC16985.1 - 2.1e-15 56.1 0.4 2.5e-15 55.9 0.3 1.1 1 0 0 1 1 1 1 AsnC family GYD PF08734.6 AIC16985.1 - 0.0097 15.6 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 GYD domain ACT_4 PF13291.1 AIC16985.1 - 0.068 13.5 0.3 1.9 8.8 0.2 2.4 1 1 1 2 2 2 0 ACT domain Transport_MerF PF11431.3 AIC16986.1 - 0.00018 21.0 0.3 0.00046 19.7 0.2 1.6 1 0 0 1 1 1 1 Membrane transport protein MerF DUF3671 PF12420.3 AIC16986.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function AsnC_trans_reg PF01037.16 AIC16987.1 - 2.5e-09 36.6 0.1 3e-09 36.4 0.1 1.0 1 0 0 1 1 1 1 AsnC family NapD PF03927.8 AIC16987.1 - 0.0047 16.7 0.2 0.0076 16.0 0.1 1.3 1 1 0 1 1 1 1 NapD protein GYD PF08734.6 AIC16987.1 - 0.11 12.2 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 GYD domain Potass_KdpF PF09604.5 AIC16988.1 - 0.25 11.2 7.3 3.7 7.5 5.0 2.4 1 1 0 1 1 1 0 F subunit of K+-transporting ATPase (Potass_KdpF) KdpC PF02669.10 AIC16989.1 - 1.1e-26 93.6 0.2 6.1e-18 65.1 0.0 2.0 1 1 1 2 2 2 2 K+-transporting ATPase, c chain E1-E2_ATPase PF00122.15 AIC16990.1 - 2.2e-36 125.0 0.9 4.4e-36 124.0 0.6 1.5 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.21 AIC16990.1 - 1.2e-28 101.0 3.6 2.8e-28 99.8 2.5 1.6 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.2 AIC16990.1 - 3.2e-12 47.0 0.0 6e-12 46.1 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.7 AIC16990.1 - 0.00066 19.3 3.4 0.00079 19.0 0.6 2.0 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase KdpA PF03814.10 AIC16991.1 - 9.7e-167 555.3 37.4 8.4e-166 552.2 25.9 1.9 1 1 0 1 1 1 1 Potassium-transporting ATPase A subunit TFIIS_C PF01096.13 AIC16992.1 - 2.1e-18 65.6 17.6 2.1e-18 65.6 5.0 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) DZR PF12773.2 AIC16992.1 - 4.2e-08 32.8 7.5 1.4e-05 24.8 0.8 2.3 2 0 0 2 2 2 2 Double zinc ribbon Prok-RING_1 PF14446.1 AIC16992.1 - 8.9e-05 22.1 1.2 8.9e-05 22.1 0.8 2.9 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 zf-DNA_Pol PF08996.5 AIC16992.1 - 9.9e-05 21.7 0.4 9.9e-05 21.7 0.2 1.9 2 1 0 2 2 2 1 DNA Polymerase alpha zinc finger zf-ribbon_3 PF13248.1 AIC16992.1 - 0.00033 19.7 4.0 0.00033 19.7 2.8 3.1 3 1 0 3 3 3 1 zinc-ribbon domain zinc_ribbon_5 PF13719.1 AIC16992.1 - 0.00054 19.4 16.6 0.088 12.4 1.1 4.2 3 1 0 3 3 3 1 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC16992.1 - 0.0006 19.4 16.7 0.11 12.2 1.3 4.2 3 1 0 3 3 3 1 zinc-ribbon domain zinc-ribbons_6 PF07191.7 AIC16992.1 - 0.00066 19.4 8.4 0.0026 17.5 0.3 2.5 2 1 0 2 2 2 1 zinc-ribbons Zn_Tnp_IS1595 PF12760.2 AIC16992.1 - 0.001 18.8 12.1 0.021 14.6 0.3 3.3 2 1 1 3 3 3 2 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.6 AIC16992.1 - 0.0031 17.1 11.0 0.0036 16.9 0.6 2.9 1 1 2 3 3 3 1 Putative transposase DNA-binding domain RNA_POL_M_15KD PF02150.11 AIC16992.1 - 0.0044 16.6 1.4 0.0044 16.6 1.0 2.9 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit Elf1 PF05129.8 AIC16992.1 - 0.012 15.3 1.2 0.012 15.3 0.8 2.7 2 2 0 2 2 2 0 Transcription elongation factor Elf1 like DNA_RNApol_7kD PF03604.8 AIC16992.1 - 0.021 14.2 8.8 0.045 13.2 0.8 3.3 3 1 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit TF_Zn_Ribbon PF08271.7 AIC16992.1 - 0.021 14.1 11.1 0.85 8.9 2.8 2.8 2 2 0 2 2 2 0 TFIIB zinc-binding Baculo_LEF5_C PF11792.3 AIC16992.1 - 0.028 13.8 0.0 0.028 13.8 0.0 2.7 2 1 0 2 2 1 0 Baculoviridae late expression factor 5 C-terminal domain HypA PF01155.14 AIC16992.1 - 0.031 13.9 9.9 0.038 13.6 0.6 3.0 1 1 2 3 3 3 0 Hydrogenase expression/synthesis hypA family Zn-ribbon_8 PF09723.5 AIC16992.1 - 0.041 13.8 14.1 11 6.0 0.4 4.1 3 1 0 3 3 3 0 Zinc ribbon domain zf-RING_3 PF14369.1 AIC16992.1 - 0.043 13.8 10.3 0.41 10.7 2.6 3.3 3 1 0 3 3 3 0 zinc-finger A2L_zn_ribbon PF08792.5 AIC16992.1 - 0.057 12.8 10.3 3.4 7.2 0.0 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain C1_4 PF07975.7 AIC16992.1 - 0.079 12.9 8.1 1.3 9.1 0.1 3.3 3 1 0 3 3 3 0 TFIIH C1-like domain UPF0547 PF10571.4 AIC16992.1 - 0.095 12.4 13.0 1.7 8.4 0.1 4.1 4 0 0 4 4 4 0 Uncharacterised protein family UPF0547 DUF4428 PF14471.1 AIC16992.1 - 0.1 12.3 0.5 1.1 9.0 0.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4428) Ogr_Delta PF04606.7 AIC16992.1 - 0.1 12.2 10.2 4.4 7.0 0.0 3.4 3 1 0 3 3 3 0 Ogr/Delta-like zinc finger zf-IS66 PF13005.2 AIC16992.1 - 0.18 11.7 0.9 0.18 11.7 0.6 3.9 3 1 1 4 4 4 0 zinc-finger binding domain of transposase IS66 Zn_Tnp_IS1 PF03811.8 AIC16992.1 - 0.27 10.7 14.0 1.2 8.6 3.0 4.0 3 1 0 3 3 3 0 InsA N-terminal domain Cript PF10235.4 AIC16992.1 - 0.27 11.6 4.8 0.37 11.1 0.1 2.6 1 1 2 3 3 3 0 Microtubule-associated protein CRIPT zf-C4_Topoisom PF01396.14 AIC16992.1 - 0.4 10.2 7.5 11 5.6 0.1 3.7 4 0 0 4 4 4 0 Topoisomerase DNA binding C4 zinc finger zinc_ribbon_2 PF13240.1 AIC16992.1 - 0.47 10.0 16.0 0.12 11.8 3.7 3.5 3 1 0 3 3 3 0 zinc-ribbon domain DUF2387 PF09526.5 AIC16992.1 - 0.48 10.3 13.4 0.22 11.4 0.5 3.1 2 1 0 2 2 2 0 Probable metal-binding protein (DUF2387) zf-RING_2 PF13639.1 AIC16992.1 - 0.51 10.2 5.4 21 5.0 0.6 3.1 3 0 0 3 3 3 0 Ring finger domain RPA_interact_C PF14768.1 AIC16992.1 - 0.59 10.5 6.7 3.2 8.2 1.4 2.8 1 1 1 2 2 2 0 Replication protein A interacting C-terminal FYDLN_acid PF09538.5 AIC16992.1 - 0.65 10.5 7.8 0.32 11.5 2.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-ISL3 PF14690.1 AIC16992.1 - 0.72 9.9 9.4 2.4 8.2 0.1 4.0 4 0 0 4 4 4 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 Lar_restr_allev PF14354.1 AIC16992.1 - 0.83 9.9 10.6 1.5 9.1 0.6 2.9 1 1 0 2 2 2 0 Restriction alleviation protein Lar UPF0515 PF15135.1 AIC16992.1 - 0.92 8.5 8.8 2.8 6.9 0.8 2.3 1 1 1 2 2 2 0 Uncharacterised protein UPF0515 zf-TFIIB PF13453.1 AIC16992.1 - 0.98 8.6 14.0 5 6.4 0.1 3.5 3 1 0 3 3 3 0 Transcription factor zinc-finger zf-Mss51 PF13824.1 AIC16992.1 - 1.2 9.0 9.9 1.2 9.0 1.0 2.7 2 1 1 3 3 2 0 Zinc-finger of mitochondrial splicing suppressor 51 IBR PF01485.16 AIC16992.1 - 1.4 8.8 12.5 1.7 8.5 0.7 2.9 2 1 0 2 2 2 0 IBR domain zf-RING_4 PF14570.1 AIC16992.1 - 1.5 8.4 8.8 12 5.5 1.8 3.3 3 1 0 3 3 3 0 RING/Ubox like zinc-binding domain zf-ZPR1 PF03367.8 AIC16992.1 - 1.8 7.6 7.5 1.3 8.2 0.0 2.6 3 1 0 3 3 2 0 ZPR1 zinc-finger domain zf-MYND PF01753.13 AIC16992.1 - 2.1 8.3 7.0 18 5.3 1.4 2.8 2 2 1 3 3 3 0 MYND finger zf-RING_5 PF14634.1 AIC16992.1 - 2.4 7.9 14.7 1.1 9.0 1.0 3.0 2 1 1 3 3 3 0 zinc-RING finger domain Zn_Tnp_IS91 PF14319.1 AIC16992.1 - 2.5 7.6 13.6 19 4.7 0.4 3.9 1 1 2 4 4 4 0 Transposase zinc-binding domain PHD PF00628.24 AIC16992.1 - 3.4 7.4 10.3 12 5.7 0.5 3.1 2 1 0 2 2 2 0 PHD-finger zf-AN1 PF01428.11 AIC16992.1 - 3.5 7.5 11.5 9.1 6.2 0.1 3.2 3 0 0 3 3 3 0 AN1-like Zinc finger Rubredoxin PF00301.15 AIC16992.1 - 3.5 7.5 13.4 2.4 8.0 0.3 4.1 3 1 1 4 4 4 0 Rubredoxin zf-C3HC4_4 PF15227.1 AIC16992.1 - 4.1 7.3 8.1 3 7.7 0.9 3.0 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING PolC_DP2 PF03833.8 AIC16992.1 - 4.2 4.9 6.6 2.3 5.7 0.7 2.0 1 1 1 2 2 2 0 DNA polymerase II large subunit DP2 DUF2719 PF10891.3 AIC16992.1 - 4.8 6.9 5.6 0.98 9.1 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2719) zf-C3HC4_2 PF13923.1 AIC16992.1 - 5.1 7.2 7.8 15 5.7 0.9 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) DUF329 PF03884.9 AIC16992.1 - 6.6 6.3 13.1 5.8 6.5 0.1 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF329) zf-C2H2 PF00096.21 AIC16992.1 - 7.7 7.0 11.2 57 4.3 0.2 4.1 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C3HC4 PF00097.20 AIC16992.1 - 9 6.0 10.1 7.5 6.3 1.2 3.1 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) RNA_pol_L_2 PF13656.1 AIC16993.1 - 1.8e-18 65.7 0.1 2.2e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.19 AIC16993.1 - 0.058 12.5 0.0 0.14 11.2 0.0 1.6 2 0 0 2 2 2 0 RNA polymerase Rpb3/Rpb11 dimerisation domain SNAPc_SNAP43 PF09808.4 AIC16993.1 - 0.1 12.2 0.1 0.12 12.0 0.1 1.0 1 0 0 1 1 1 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 LGFP PF08310.6 AIC16994.1 - 0.0021 17.6 0.1 3.7 7.2 0.0 2.8 3 0 0 3 3 3 2 LGFP repeat TPR_1 PF00515.23 AIC16995.1 - 1.5e-07 30.7 0.1 5.9e-07 28.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.1 AIC16995.1 - 2.1e-07 30.4 0.2 7.4e-07 28.7 0.0 2.0 2 1 0 2 2 2 1 TPR repeat TPR_2 PF07719.12 AIC16995.1 - 2.6e-06 26.8 0.2 7.9e-06 25.4 0.0 2.0 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_12 PF13424.1 AIC16995.1 - 1.9e-05 24.4 0.3 0.00045 20.1 0.1 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.1 AIC16995.1 - 2.8e-05 23.8 0.3 6.4e-05 22.7 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.1 AIC16995.1 - 0.00046 19.7 0.0 0.0016 18.0 0.0 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.1 AIC16995.1 - 0.0021 18.5 0.2 0.0065 17.0 0.0 2.0 2 1 0 2 2 1 1 Tetratricopeptide repeat Coatomer_E PF04733.9 AIC16995.1 - 0.0021 17.3 0.2 0.0053 16.0 0.1 1.6 1 1 1 2 2 2 1 Coatomer epsilon subunit TPR_19 PF14559.1 AIC16995.1 - 0.0034 17.6 0.7 0.0058 16.9 0.1 1.6 2 0 0 2 2 1 1 Tetratricopeptide repeat RICH PF05062.7 AIC16995.1 - 0.006 16.6 1.3 0.013 15.5 0.9 1.5 1 0 0 1 1 1 1 RICH domain TPR_16 PF13432.1 AIC16995.1 - 0.0069 17.0 0.0 0.02 15.5 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat AAA_11 PF13086.1 AIC16995.1 - 0.012 15.1 0.2 0.013 15.0 0.2 1.1 1 0 0 1 1 1 0 AAA domain TPR_7 PF13176.1 AIC16995.1 - 0.012 15.3 0.2 0.045 13.5 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.1 AIC16995.1 - 0.033 14.3 0.0 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Acetyltransf_2 PF00797.12 AIC16995.1 - 0.045 13.3 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 N-acetyltransferase NAS PF03059.11 AIC16997.1 - 0.077 12.1 0.1 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Nicotianamine synthase protein HTH_45 PF14947.1 AIC16998.1 - 1.5e-10 40.6 0.0 1.8e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.17 AIC16999.1 - 2.5e-15 55.8 0.0 4.8e-15 55.0 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.2 AIC16999.1 - 2.8e-10 39.7 0.0 4.8e-10 38.9 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.1 AIC16999.1 - 6.9e-09 35.9 0.0 1.3e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.14 AIC16999.1 - 5.3e-06 26.0 0.0 9.9e-06 25.1 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.12 AIC16999.1 - 0.0018 17.7 0.2 0.004 16.6 0.1 1.6 1 1 1 2 2 2 1 TFIIE alpha subunit FeoC PF09012.5 AIC16999.1 - 0.0019 17.8 0.1 0.0099 15.5 0.0 2.0 2 0 0 2 2 2 1 FeoC like transcriptional regulator PadR PF03551.9 AIC16999.1 - 0.0028 17.3 0.0 0.0055 16.4 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family DUF2250 PF10007.4 AIC16999.1 - 0.0059 16.4 0.1 0.013 15.3 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) Rrf2 PF02082.15 AIC16999.1 - 0.013 15.5 0.0 0.036 14.1 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_24 PF13412.1 AIC16999.1 - 0.023 14.0 0.2 0.19 11.1 0.1 2.6 2 1 1 3 3 3 0 Winged helix-turn-helix DNA-binding Fe_dep_repress PF01325.14 AIC16999.1 - 0.032 14.1 0.0 0.084 12.8 0.0 1.7 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain HTH_34 PF13601.1 AIC16999.1 - 0.057 13.4 0.0 0.092 12.7 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HxlR PF01638.12 AIC16999.1 - 0.1 12.2 0.1 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 HxlR-like helix-turn-helix MFS_1 PF07690.11 AIC17000.1 - 9.9e-36 123.1 57.8 5.3e-29 101.0 20.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Radical_SAM PF04055.16 AIC17001.1 - 2.4e-13 50.6 0.1 3.9e-13 49.9 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.1 AIC17001.1 - 0.0001 22.4 0.1 0.00024 21.2 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.1 AIC17001.1 - 0.082 12.9 0.3 0.26 11.3 0.1 2.0 2 0 0 2 2 2 0 4Fe-4S single cluster domain Archaeal_AmoA PF12942.2 AIC17003.1 - 8.2e-106 351.6 11.0 9.8e-106 351.4 7.6 1.0 1 0 0 1 1 1 1 Archaeal ammonia monooxygenase subunit A (AmoA) DUF2436 PF10365.4 AIC17005.1 - 0.0026 17.4 0.2 0.017 14.7 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF2436) FlgD_ig PF13860.1 AIC17005.1 - 0.0048 16.6 2.2 0.15 11.8 0.1 3.2 2 1 1 3 3 3 2 FlgD Ig-like domain DUF3108 PF11306.3 AIC17005.1 - 0.0092 15.6 0.4 0.33 10.5 0.0 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3108) Big_1 PF02369.11 AIC17005.1 - 0.027 14.3 1.4 0.12 12.2 0.8 2.2 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 1) Big_3_4 PF13754.1 AIC17005.1 - 0.42 10.9 9.8 0.26 11.6 2.3 3.4 3 1 1 4 4 4 0 Bacterial Ig-like domain (group 3) Flp_Fap PF04964.9 AIC17005.1 - 4.9 6.8 7.8 2.4 7.8 0.8 2.5 2 0 0 2 2 2 0 Flp/Fap pilin component DUF2414 PF10309.4 AIC17007.1 - 0.055 13.1 0.1 0.16 11.6 0.0 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2414) Cys_rich_CPCC PF14206.1 AIC17008.1 - 0.015 14.8 1.3 0.062 12.8 0.2 2.1 2 0 0 2 2 2 0 Cysteine-rich CPCC Zn_ribbon_recom PF13408.1 AIC17008.1 - 0.13 12.5 0.7 0.13 12.5 0.5 2.0 2 1 0 2 2 2 0 Recombinase zinc beta ribbon domain UDPG_MGDP_dh_N PF03721.9 AIC17010.1 - 7.9e-36 123.1 0.0 3e-35 121.2 0.0 1.8 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.10 AIC17010.1 - 8.5e-23 80.5 0.0 5.9e-22 77.8 0.0 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.14 AIC17010.1 - 3.2e-21 75.3 0.0 7.6e-21 74.1 0.0 1.7 2 0 0 2 2 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain NAD_Gly3P_dh_N PF01210.18 AIC17010.1 - 3.5e-06 26.8 0.0 0.076 12.7 0.0 2.5 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.14 AIC17010.1 - 6e-05 22.2 0.3 0.0024 17.0 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.13 AIC17010.1 - 7.5e-05 22.4 0.0 0.0011 18.7 0.0 2.2 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.13 AIC17010.1 - 0.00021 21.2 0.1 0.019 14.9 0.0 2.5 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_2 PF03446.10 AIC17010.1 - 0.00093 19.0 0.1 0.0058 16.4 0.0 2.4 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.12 AIC17010.1 - 0.0012 19.2 0.6 1.2 9.6 0.0 3.4 3 1 1 4 4 4 1 NADP oxidoreductase coenzyme F420-dependent Methyltransf_18 PF12847.2 AIC17010.1 - 0.014 15.9 0.0 0.084 13.4 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase domain Androgen_recep PF02166.11 AIC17010.1 - 0.016 14.0 0.0 0.024 13.5 0.0 1.1 1 0 0 1 1 1 0 Androgen receptor AlaDh_PNT_C PF01262.16 AIC17010.1 - 0.021 14.3 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.1 AIC17010.1 - 0.023 14.9 0.4 1.1 9.5 0.1 2.5 2 0 0 2 2 2 0 Putative NAD(P)-binding Methyltransf_31 PF13847.1 AIC17010.1 - 0.16 11.5 0.0 0.39 10.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain ThiF PF00899.16 AIC17010.1 - 0.22 11.3 1.5 3.9 7.2 0.2 2.7 2 1 0 2 2 2 0 ThiF family DUF1049 PF06305.6 AIC17011.1 - 0.028 13.9 3.2 0.66 9.4 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) IncA PF04156.9 AIC17011.1 - 0.05 13.2 5.2 0.068 12.7 0.1 2.0 2 0 0 2 2 2 0 IncA protein IF-2B PF01008.12 AIC17012.1 - 3.6e-91 305.0 0.0 4.3e-91 304.7 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family DUF1599 PF07659.6 AIC17012.1 - 0.15 12.1 0.1 0.44 10.6 0.0 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1599) DUF59 PF01883.14 AIC17013.1 - 1.3e-15 57.1 0.0 3e-15 55.9 0.0 1.6 2 0 0 2 2 2 1 Domain of unknown function DUF59 PqqD PF05402.7 AIC17013.1 - 3.8e-08 33.2 0.1 5.9e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) Methyltransf_4 PF02390.12 AIC17014.1 - 2e-10 40.0 0.0 2.6e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_26 PF13659.1 AIC17014.1 - 1.1e-06 28.6 0.0 1.6e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC17014.1 - 1.7e-06 28.4 0.0 6.4e-06 26.5 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC17014.1 - 1.8e-05 25.2 0.0 2.9e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC17014.1 - 3e-05 23.6 0.0 3.5e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC17014.1 - 0.0064 16.9 0.0 0.011 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC17014.1 - 0.011 16.0 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.7 AIC17014.1 - 0.02 14.2 0.0 0.029 13.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_24 PF13578.1 AIC17014.1 - 0.021 15.6 0.0 0.039 14.7 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain HTH_45 PF14947.1 AIC17015.1 - 8.7e-12 44.6 0.0 1e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC17015.1 - 0.13 11.8 0.0 0.68 9.5 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) DUF342 PF03961.8 AIC17016.1 - 8.1e-06 24.5 26.1 0.00092 17.7 9.0 3.1 1 1 1 2 2 2 2 Protein of unknown function (DUF342) Bactofilin PF04519.8 AIC17016.1 - 2e-05 24.4 35.1 0.084 12.9 0.0 5.2 1 1 3 5 5 5 5 Polymer-forming cytoskeletal MFS_1 PF07690.11 AIC17017.1 - 1.6e-50 171.7 57.2 2.2e-42 145.0 23.8 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.1 AIC17017.1 - 1.7e-17 62.9 39.6 1.1e-10 40.5 7.2 2.9 1 1 2 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.2 AIC17017.1 - 0.0005 19.7 4.0 0.00086 19.0 1.6 2.4 2 0 0 2 2 2 1 MFS_1 like family FMN_red PF03358.10 AIC17019.1 - 3.2e-28 98.1 0.0 3.8e-28 97.9 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.12 AIC17019.1 - 1.4e-11 44.2 0.0 1.9e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Usp PF00582.21 AIC17019.1 - 0.0045 17.1 0.2 0.0082 16.3 0.1 1.4 1 0 0 1 1 1 1 Universal stress protein family Flavodoxin_5 PF12724.2 AIC17019.1 - 0.0081 16.1 0.0 0.02 14.8 0.0 1.7 2 0 0 2 2 2 1 Flavodoxin domain HTH_20 PF12840.2 AIC17020.1 - 3.8e-14 52.2 0.1 6.1e-14 51.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.15 AIC17020.1 - 5.6e-14 51.5 0.0 9.6e-14 50.7 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HxlR PF01638.12 AIC17020.1 - 0.00073 19.1 0.0 0.001 18.6 0.0 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix MarR_2 PF12802.2 AIC17020.1 - 0.0011 18.5 0.1 0.0019 17.8 0.1 1.4 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC17020.1 - 0.0076 15.9 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.1 AIC17020.1 - 0.017 15.1 0.0 0.026 14.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_24 PF13412.1 AIC17020.1 - 0.023 14.0 0.0 0.054 12.8 0.0 1.7 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF2513 PF10711.4 AIC17020.1 - 0.041 13.9 0.0 0.057 13.5 0.0 1.3 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) HTH_1 PF00126.22 AIC17020.1 - 0.076 12.7 0.2 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family AHSA1 PF08327.6 AIC17021.1 - 1.3e-18 67.2 0.0 1.7e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.4 AIC17021.1 - 6.6e-09 36.0 0.3 9.9e-09 35.4 0.2 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 AIC17021.1 - 0.071 13.1 0.9 0.67 9.9 0.6 2.1 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport PEGSRP PF07623.6 AIC17022.1 - 5.2e-05 22.4 0.4 9.1e-05 21.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1584) zf-FCS PF06467.9 AIC17022.1 - 0.028 14.0 8.5 0.074 12.6 5.9 1.7 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-MYND PF01753.13 AIC17022.1 - 0.24 11.2 7.5 0.46 10.4 5.2 1.6 1 1 0 1 1 1 0 MYND finger DUF581 PF04570.9 AIC17022.1 - 5.1 6.4 8.5 14 5.0 5.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF581) tRNA-synt_2b PF00587.20 AIC17023.1 - 1.5e-46 158.1 0.0 2.5e-46 157.3 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.15 AIC17023.1 - 4e-18 65.1 0.0 9.3e-18 63.9 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain zinc_ribbon_5 PF13719.1 AIC17023.1 - 1.6 8.3 5.6 0.72 9.4 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Aminotran_1_2 PF00155.16 AIC17024.1 - 1.5e-60 205.0 0.0 1.7e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.12 AIC17024.1 - 3.6e-06 26.2 0.0 1.2e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.14 AIC17024.1 - 4.8e-06 25.5 0.0 7.7e-06 24.8 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 AIC17024.1 - 7.3e-05 22.0 0.0 0.00013 21.2 0.0 1.5 1 1 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.15 AIC17024.1 - 0.00035 18.9 0.0 0.00061 18.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Rad60-SLD_2 PF13881.1 AIC17025.1 - 0.057 13.3 0.1 0.11 12.4 0.0 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like MRP-S31 PF15433.1 AIC17025.1 - 1.1 8.6 4.0 1.2 8.5 2.7 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 DUF308 PF03729.8 AIC17026.1 - 0.00069 19.5 3.3 0.03 14.3 0.2 2.7 2 1 1 3 3 3 1 Short repeat of unknown function (DUF308) DUF1469 PF07332.6 AIC17026.1 - 0.0028 17.3 0.4 0.0052 16.5 0.3 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1469) TctB PF07331.6 AIC17026.1 - 0.01 15.4 0.0 1.7 8.3 0.0 2.1 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family BacA PF02673.13 AIC17026.1 - 0.02 14.1 0.0 0.032 13.4 0.0 1.4 1 1 0 1 1 1 0 Bacitracin resistance protein BacA Pox_A14 PF05767.7 AIC17026.1 - 0.022 14.7 2.7 0.15 12.0 1.9 2.0 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF204 PF02659.10 AIC17026.1 - 0.93 9.6 4.7 1.3 9.2 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function DUF F420_oxidored PF03807.12 AIC17027.1 - 2.7e-14 53.3 0.0 4.9e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_Gly3P_dh_N PF01210.18 AIC17027.1 - 2.9e-05 23.8 0.0 3.8e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus PDH PF02153.12 AIC17027.1 - 0.0014 17.5 0.0 0.002 17.0 0.0 1.3 1 0 0 1 1 1 1 Prephenate dehydrogenase VOMI PF03762.12 AIC17027.1 - 0.054 13.4 0.0 2.9 7.8 0.0 2.1 2 0 0 2 2 2 0 Vitelline membrane outer layer protein I (VOMI) His_Phos_1 PF00300.17 AIC17028.1 - 3.9e-31 108.2 0.0 4.8e-31 107.9 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Yip1 PF04893.12 AIC17029.1 - 0.0017 17.9 1.5 0.0021 17.5 1.1 1.0 1 0 0 1 1 1 1 Yip1 domain Virul_fac_BrkB PF03631.10 AIC17029.1 - 0.0082 15.5 1.8 0.0097 15.2 1.2 1.0 1 0 0 1 1 1 1 Virulence factor BrkB DUF3311 PF11755.3 AIC17029.1 - 0.027 13.9 4.1 2.5 7.6 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3311) DUF1049 PF06305.6 AIC17029.1 - 0.044 13.2 0.1 0.044 13.2 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1049) DUF2500 PF10694.4 AIC17029.1 - 0.055 13.4 0.6 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) DUF1191 PF06697.7 AIC17029.1 - 0.063 12.0 0.0 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1191) MpPF26 PF07666.6 AIC17029.1 - 0.072 12.9 1.2 0.1 12.4 0.8 1.3 1 1 0 1 1 1 0 M penetrans paralogue family 26 Tmpp129 PF10272.4 AIC17029.1 - 0.12 11.0 0.2 0.12 11.0 0.1 1.0 1 0 0 1 1 1 0 Putative transmembrane protein precursor DUF3816 PF12822.2 AIC17029.1 - 0.44 10.4 4.6 0.63 9.9 3.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3816) Pox_A14 PF05767.7 AIC17029.1 - 1.9 8.5 4.4 3.9 7.5 3.1 1.7 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 COX2 PF00116.15 AIC17030.1 - 2e-22 79.2 0.1 4.3e-20 71.7 0.1 2.1 1 1 0 1 1 1 1 Cytochrome C oxidase subunit II, periplasmic domain Cupredoxin_1 PF13473.1 AIC17030.1 - 0.0012 18.6 0.0 0.0016 18.3 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain COX1 PF00115.15 AIC17031.1 - 2.4e-141 471.4 63.8 3e-141 471.0 44.2 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Cupredoxin_1 PF13473.1 AIC17032.1 - 4.1e-11 42.7 0.0 1.4e-05 24.9 0.0 2.8 2 1 0 2 2 2 2 Cupredoxin-like domain Copper-bind PF00127.15 AIC17032.1 - 1.7e-09 37.8 0.0 5.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family COX15-CtaA PF02628.10 AIC17033.1 - 3.6e-30 104.8 4.4 4.7e-30 104.4 3.1 1.2 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein DUF420 PF04238.7 AIC17033.1 - 0.013 15.4 7.0 0.12 12.3 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF420) GspL_C PF12693.2 AIC17033.1 - 0.014 15.1 0.2 0.023 14.4 0.1 1.3 1 0 0 1 1 1 0 GspL periplasmic domain DUF4079 PF13301.1 AIC17033.1 - 0.022 14.7 7.2 0.028 14.4 5.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) IncA PF04156.9 AIC17033.1 - 0.03 13.9 1.4 0.03 13.9 1.0 2.3 2 0 0 2 2 2 0 IncA protein Ni_hydr_CYTB PF01292.15 AIC17033.1 - 0.088 12.1 4.3 0.83 9.0 2.4 2.0 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Cytochrom_B561 PF03188.11 AIC17033.1 - 0.26 11.1 8.2 1.2 8.9 5.7 1.9 1 1 0 1 1 1 0 Eukaryotic cytochrome b561 RTX PF02382.10 AIC17033.1 - 0.3 9.2 2.7 0.34 9.1 1.9 1.0 1 0 0 1 1 1 0 RTX N-terminal domain DUF1049 PF06305.6 AIC17033.1 - 0.35 10.3 0.1 0.35 10.3 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1049) DUF4203 PF13886.1 AIC17033.1 - 0.96 8.8 12.6 0.021 14.2 4.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) HCV_NS4a PF01006.15 AIC17033.1 - 1.2 8.6 6.4 15 5.2 0.7 3.0 3 0 0 3 3 3 0 Hepatitis C virus non-structural protein NS4a Tetraspannin PF00335.15 AIC17033.1 - 4.6 6.4 6.2 0.23 10.6 0.3 1.6 2 0 0 2 2 2 0 Tetraspanin family LGT PF01790.13 AIC17034.1 - 0.0015 17.5 3.0 0.0015 17.5 2.1 2.0 2 0 0 2 2 2 1 Prolipoprotein diacylglyceryl transferase DUF202 PF02656.10 AIC17034.1 - 0.15 12.3 5.0 19 5.5 0.0 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF202) Acyl_transf_3 PF01757.17 AIC17034.1 - 0.25 10.1 5.6 0.13 11.0 2.1 1.8 1 1 0 1 1 1 0 Acyltransferase family DUF4079 PF13301.1 AIC17034.1 - 3.2 7.7 8.5 0.26 11.2 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) Fe-ADH PF00465.14 AIC17035.1 - 2.5e-50 171.1 0.0 5.6e-50 170.0 0.0 1.5 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.1 AIC17035.1 - 2.6e-17 62.9 0.0 3.6e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Polyketide_cyc2 PF10604.4 AIC17036.1 - 5.4e-11 42.8 0.0 6.7e-11 42.5 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 AIC17036.1 - 2.4e-07 30.8 0.0 3.6e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.6 AIC17036.1 - 7.5e-07 29.2 0.0 1.1e-06 28.7 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DUF217 PF02697.9 AIC17036.1 - 0.0016 18.6 0.1 0.0035 17.5 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized ACR, COG1753 TetR_N PF00440.18 AIC17037.1 - 6.9e-17 60.8 0.2 1.6e-16 59.6 0.1 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.1 AIC17037.1 - 3.4e-12 46.3 0.0 9.8e-12 44.9 0.0 1.8 1 0 0 1 1 1 1 Bacterial transcriptional repressor TetR_C_2 PF08361.6 AIC17037.1 - 0.0024 17.7 0.2 0.0068 16.3 0.0 1.8 2 0 0 2 2 2 1 MAATS-type transcriptional repressor, C-terminal region Coat_F PF07875.7 AIC17037.1 - 0.0041 17.2 1.9 0.46 10.6 0.0 3.1 3 0 0 3 3 3 1 Coat F domain DUF4118 PF13493.1 AIC17039.1 - 4.4 7.5 14.1 5.3 7.3 4.6 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4118) DUF3353 PF11833.3 AIC17039.1 - 5.2 6.4 11.6 0.4 10.1 0.4 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF3353) Methyltransf_31 PF13847.1 AIC17041.1 - 3.5e-12 46.1 0.0 6.3e-11 42.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC17041.1 - 1.1e-11 45.1 0.0 1e-10 41.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.13 AIC17041.1 - 6.3e-10 38.5 0.0 5.9e-09 35.3 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_18 PF12847.2 AIC17041.1 - 5.3e-08 33.4 0.0 1.9e-07 31.6 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC17041.1 - 2.1e-07 31.3 0.0 3.4e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC17041.1 - 3.1e-06 26.9 0.0 5.9e-06 26.0 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC17041.1 - 3.4e-05 24.1 0.0 7.8e-05 22.9 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC17041.1 - 0.0002 21.3 0.0 0.00095 19.1 0.0 2.1 3 0 0 3 3 3 1 Methyltransferase domain UPF0020 PF01170.13 AIC17041.1 - 0.0013 18.3 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 DNA_RNApol_7kD PF03604.8 AIC17045.1 - 0.011 15.2 4.8 0.019 14.4 3.3 1.5 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DZR PF12773.2 AIC17045.1 - 0.013 15.2 1.1 0.015 15.0 0.8 1.2 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.1 AIC17045.1 - 0.032 13.4 1.4 0.045 12.9 1.0 1.2 1 0 0 1 1 1 0 zinc-ribbon domain DUF2024 PF09630.5 AIC17045.1 - 0.039 13.6 0.7 0.044 13.4 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) DnaJ_CXXCXGXG PF00684.14 AIC17045.1 - 0.053 13.5 1.3 0.06 13.3 0.9 1.1 1 0 0 1 1 1 0 DnaJ central domain Ribosomal_L40e PF01020.12 AIC17045.1 - 0.059 12.9 5.6 0.07 12.7 3.8 1.2 1 0 0 1 1 1 0 Ribosomal L40e family PocR PF10114.4 AIC17045.1 - 0.13 11.3 0.7 0.12 11.4 0.5 1.0 1 0 0 1 1 1 0 Sensory domain found in PocR Flag1_repress PF03614.8 AIC17045.1 - 1.1 8.7 3.7 0.98 8.9 0.4 1.8 1 1 1 2 2 2 0 Repressor of phase-1 flagellin Haem_bd PF14376.1 AIC17045.1 - 1.3 8.6 4.1 1 9.0 1.9 1.5 1 1 1 2 2 2 0 Haem-binding domain Paired_CXXCH_1 PF09699.5 AIC17045.1 - 2.6 7.6 6.0 2.5 7.6 1.0 2.1 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) BAF1_ABF1 PF04684.8 AIC17047.1 - 0.99 8.1 4.0 1.1 8.0 2.8 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor HEM4 PF02602.10 AIC17050.1 - 1e-42 145.9 1.1 1.2e-42 145.7 0.8 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD NMT1 PF09084.6 AIC17050.1 - 0.038 13.5 0.0 0.23 11.0 0.0 2.0 2 0 0 2 2 2 0 NMT1/THI5 like TP_methylase PF00590.15 AIC17051.1 - 1e-47 162.5 0.1 1.2e-47 162.3 0.1 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DEC-1_C PF04626.8 AIC17051.1 - 0.026 14.6 0.1 0.054 13.6 0.1 1.5 1 0 0 1 1 1 0 Dec-1 protein, C terminal region Porphobil_deam PF01379.15 AIC17052.1 - 1.2e-74 249.8 0.3 1.6e-74 249.4 0.2 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.10 AIC17052.1 - 1e-16 60.7 0.6 3.4e-16 59.1 0.1 2.2 3 0 0 3 3 3 1 Porphobilinogen deaminase, C-terminal domain LysR_substrate PF03466.15 AIC17052.1 - 5.1e-05 22.4 0.0 0.036 13.1 0.0 3.2 3 0 0 3 3 3 1 LysR substrate binding domain SBP_bac_3 PF00497.15 AIC17052.1 - 0.0019 17.4 0.0 0.0047 16.1 0.0 1.6 1 1 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 YfdX PF10938.3 AIC17052.1 - 0.0046 16.6 0.1 0.0079 15.8 0.0 1.3 1 0 0 1 1 1 1 YfdX protein ArsC PF03960.10 AIC17052.1 - 0.042 13.9 0.0 0.098 12.7 0.0 1.5 1 0 0 1 1 1 0 ArsC family DUF4258 PF14076.1 AIC17052.1 - 0.099 12.6 0.0 0.38 10.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4258) Aminotran_3 PF00202.16 AIC17053.1 - 1.2e-60 205.2 0.1 1.4e-60 204.9 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.16 AIC17053.1 - 2.7e-09 36.4 0.0 4e-09 35.8 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF3108 PF11306.3 AIC17055.1 - 1.1e-06 28.4 1.5 7.3e-06 25.8 1.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF3108) EVE PF01878.13 AIC17056.1 - 7.8e-41 139.4 0.2 8.8e-41 139.2 0.2 1.0 1 0 0 1 1 1 1 EVE domain GNAT_acetyltr_2 PF13718.1 AIC17056.1 - 0.12 11.7 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 TruD PF01142.13 AIC17057.1 - 9.9e-60 202.1 0.0 1.2e-59 201.8 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) HTH_45 PF14947.1 AIC17059.1 - 4.3e-07 29.6 0.0 5.8e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.17 AIC17059.1 - 0.00034 20.2 0.7 0.00047 19.7 0.0 1.5 2 0 0 2 2 2 1 MarR family TrmB PF01978.14 AIC17059.1 - 0.0083 15.8 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB PadR PF03551.9 AIC17059.1 - 0.018 14.7 0.0 0.034 13.8 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Enterotoxin_HS1 PF08090.6 AIC17060.1 - 2.8 7.7 10.0 11 5.8 0.2 2.5 2 1 0 2 2 2 0 Heat stable E.coli enterotoxin 1 Me-amine-dh_L PF02975.9 AIC17061.1 - 0.0028 17.6 0.4 0.0035 17.3 0.3 1.2 1 0 0 1 1 1 1 Methylamine dehydrogenase, L chain Cys_rich_CPCC PF14206.1 AIC17061.1 - 0.036 13.6 0.5 0.036 13.6 0.4 2.0 2 0 0 2 2 2 0 Cysteine-rich CPCC SPASM PF13186.1 AIC17061.1 - 2.8 8.3 7.6 2.4 8.5 4.3 1.7 1 1 1 2 2 2 0 Iron-sulfur cluster-binding domain zf-H2C2_5 PF13909.1 AIC17061.1 - 4.8 7.6 5.6 15 6.0 0.4 2.4 1 1 1 2 2 2 0 C2H2-type zinc-finger domain Trypsin_2 PF13365.1 AIC17062.1 - 2.6e-23 82.2 0.5 5.4e-23 81.2 0.3 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.21 AIC17062.1 - 1.8e-16 60.3 0.3 4.2e-16 59.1 0.2 1.5 1 1 0 1 1 1 1 Trypsin PDZ_2 PF13180.1 AIC17062.1 - 1.4e-15 56.9 0.6 1.9e-14 53.2 0.1 2.7 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.19 AIC17062.1 - 5.3e-05 23.3 2.1 0.16 12.1 0.1 3.8 3 1 0 3 3 3 1 PDZ domain (Also known as DHR or GLGF) Tricorn_PDZ PF14685.1 AIC17062.1 - 0.0012 18.5 0.3 0.0043 16.8 0.1 2.1 2 0 0 2 2 2 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.4 AIC17062.1 - 0.0061 15.0 2.7 0.061 11.7 0.5 2.1 2 0 0 2 2 2 1 Peptidase S46 Peptidase_S29 PF02907.10 AIC17062.1 - 0.02 14.4 0.0 0.049 13.1 0.0 1.7 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Cas_Cas4 PF01930.12 AIC17063.1 - 0.00012 21.9 0.0 0.0002 21.3 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function DUF83 LEA_2 PF03168.8 AIC17065.1 - 0.0037 17.6 0.1 0.0057 16.9 0.1 1.5 1 1 0 1 1 1 1 Late embryogenesis abundant protein DUF3712 PF12505.3 AIC17065.1 - 0.0069 16.4 0.3 0.014 15.3 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3712) Big_2 PF02368.13 AIC17065.1 - 0.036 13.9 1.1 0.083 12.7 0.3 1.9 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 2) NicO PF03824.11 AIC17067.1 - 0.0051 16.1 22.1 0.034 13.4 15.3 2.0 1 1 0 1 1 1 1 High-affinity nickel-transport protein APG9 PF04109.11 AIC17067.1 - 0.17 10.7 1.6 0.19 10.5 0.4 1.5 2 0 0 2 2 2 0 Autophagy protein Apg9 FixQ PF05545.6 AIC17067.1 - 0.62 9.7 3.2 3.8 7.2 0.0 2.8 1 1 1 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF3754 PF12576.3 AIC17067.1 - 0.97 9.0 3.4 0.97 9.0 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3754) AA_kinase PF00696.23 AIC17068.1 - 1.5e-32 113.0 3.1 1.8e-32 112.7 2.1 1.1 1 0 0 1 1 1 1 Amino acid kinase family TatD_DNase PF01026.16 AIC17068.1 - 0.031 13.5 0.0 0.036 13.2 0.0 1.1 1 0 0 1 1 1 0 TatD related DNase HD PF01966.17 AIC17069.1 - 2.1e-13 50.3 0.3 2.1e-13 50.3 0.2 1.7 2 0 0 2 2 2 1 HD domain HDOD PF08668.7 AIC17069.1 - 0.031 13.5 0.1 0.066 12.4 0.0 1.6 1 0 0 1 1 1 0 HDOD domain Thymidylate_kin PF02223.12 AIC17070.1 - 4.1e-31 107.8 0.0 4.7e-31 107.5 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.1 AIC17070.1 - 0.0099 15.8 0.0 0.013 15.4 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC17070.1 - 0.022 15.5 0.1 0.042 14.6 0.0 1.7 1 1 0 1 1 1 0 AAA domain CPT PF07931.7 AIC17070.1 - 0.033 13.7 0.0 0.078 12.6 0.0 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_35 PF14516.1 AIC17070.1 - 0.059 11.9 0.0 0.081 11.5 0.0 1.3 1 0 0 1 1 1 0 AAA-like domain UPF0079 PF02367.12 AIC17070.1 - 0.067 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised P-loop hydrolase UPF0079 Zeta_toxin PF06414.7 AIC17070.1 - 0.084 11.9 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin DUF374 PF04028.8 AIC17070.1 - 0.12 11.6 0.1 6.6 6.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF374) C1_3 PF07649.7 AIC17072.1 - 0.0079 16.2 11.4 0.26 11.3 0.9 2.9 2 0 0 2 2 2 2 C1-like domain Rubredoxin PF00301.15 AIC17072.1 - 0.92 9.4 15.8 1.3 8.9 1.3 3.9 1 1 2 3 3 3 0 Rubredoxin DUF1610 PF07754.6 AIC17072.1 - 1.1 9.4 30.4 0.19 11.8 2.8 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) zf-RING_3 PF14369.1 AIC17072.1 - 1.3 9.0 10.9 0.42 10.6 1.9 2.9 2 0 0 2 2 2 0 zinc-finger Sgf11 PF08209.6 AIC17072.1 - 1.3 8.3 0.1 1.3 8.3 0.1 4.3 5 0 0 5 5 5 0 Sgf11 (transcriptional regulation protein) DZR PF12773.2 AIC17072.1 - 3.2 7.6 19.0 4e+02 0.9 13.2 3.0 1 1 0 1 1 1 0 Double zinc ribbon zf-Mss51 PF13824.1 AIC17072.1 - 6.9 6.6 12.4 7.2 6.5 1.7 2.6 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 OrfB_Zn_ribbon PF07282.6 AIC17072.1 - 9.2 6.0 19.1 3.4e+02 0.9 8.8 3.2 2 1 0 2 2 2 0 Putative transposase DNA-binding domain HSP20 PF00011.16 AIC17073.1 - 1.9e-10 40.4 0.0 2.7e-10 40.0 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ABC1 PF03109.11 AIC17074.1 - 3.5e-28 97.9 0.0 9.2e-28 96.6 0.0 1.7 1 0 0 1 1 1 1 ABC1 family APH PF01636.18 AIC17074.1 - 6.4e-06 26.0 0.1 0.0011 18.8 0.1 3.1 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.17 AIC17074.1 - 0.00028 20.2 0.1 0.001 18.4 0.0 1.9 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.20 AIC17074.1 - 0.006 15.7 0.1 0.022 13.9 0.1 1.8 1 1 0 1 1 1 1 Protein kinase domain CesT PF05932.8 AIC17074.1 - 0.037 13.8 0.0 0.14 12.0 0.0 2.0 1 1 1 2 2 2 0 Tir chaperone protein (CesT) family Gram_pos_anchor PF00746.16 AIC17074.1 - 0.49 10.2 5.4 0.35 10.7 0.6 2.3 2 0 0 2 2 2 0 Gram positive anchor Arch_ATPase PF01637.13 AIC17075.1 - 0.0011 18.7 0.0 0.002 17.8 0.0 1.3 1 0 0 1 1 1 1 Archaeal ATPase PapG_C PF03628.8 AIC17075.1 - 0.0087 15.7 1.2 12 5.5 0.0 5.6 6 0 0 6 6 6 1 PapG chaperone-binding domain RNA_helicase PF00910.17 AIC17075.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_22 PF13401.1 AIC17075.1 - 0.085 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.1 AIC17075.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Glucokinase PF02685.11 AIC17075.1 - 6.5 5.4 5.8 4.4 5.9 0.0 3.5 5 1 1 6 6 6 0 Glucokinase Guanylate_cyc PF00211.15 AIC17076.1 - 8e-11 41.6 0.0 1.1e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Gly-zipper_Omp PF13488.1 AIC17077.1 - 0.34 10.5 6.9 1.1 9.0 4.8 1.9 1 1 0 1 1 1 0 Glycine zipper Gly-zipper_OmpA PF13436.1 AIC17077.1 - 5.4 6.7 8.9 0.14 11.8 1.2 1.9 2 1 1 3 3 3 0 Glycine-zipper containing OmpA-like membrane domain NUDIX PF00293.23 AIC17079.1 - 5e-19 68.2 0.0 6.1e-19 68.0 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain Aconitase PF00330.15 AIC17079.1 - 0.015 13.7 0.0 0.016 13.7 0.0 1.1 1 0 0 1 1 1 0 Aconitase family (aconitate hydratase) ComA PF02679.10 AIC17080.1 - 7.7e-50 169.1 0.1 1.1e-49 168.6 0.1 1.2 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) MarR_2 PF12802.2 AIC17080.1 - 3.6e-05 23.3 0.0 6.6e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC17080.1 - 0.0039 16.8 0.1 0.0095 15.6 0.1 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB AP_endonuc_2 PF01261.19 AIC17080.1 - 0.0057 15.9 0.0 0.0097 15.2 0.0 1.4 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel MarR PF01047.17 AIC17080.1 - 0.024 14.3 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_43 PF09904.4 AIC17080.1 - 0.1 12.4 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix NMT1_2 PF13379.1 AIC17081.1 - 3.4e-35 121.6 0.0 4.3e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.6 AIC17081.1 - 1.7e-13 50.6 0.0 2.3e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.2 AIC17081.1 - 3.7e-09 36.3 0.0 1.8e-08 34.0 0.0 2.0 1 1 1 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.15 AIC17081.1 - 6.2e-06 25.6 0.0 0.0043 16.3 0.0 2.4 1 1 1 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 B5 PF03484.10 AIC17081.1 - 0.0057 16.4 0.0 0.018 14.8 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetase B5 domain BPD_transp_1 PF00528.17 AIC17082.1 - 1.4e-16 60.5 18.8 1.4e-16 60.5 13.0 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component Pterin_4a PF01329.14 AIC17083.1 - 4.4e-32 109.6 0.4 5e-32 109.5 0.3 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase A2M_N PF01835.14 AIC17084.1 - 0.0031 17.7 0.4 0.016 15.4 0.1 2.4 3 0 0 3 3 3 1 MG2 domain DnaJ_CXXCXGXG PF00684.14 AIC17086.1 - 0.0034 17.3 12.3 0.0092 16.0 8.6 1.7 1 1 0 1 1 1 1 DnaJ central domain PsaL PF02605.10 AIC17087.1 - 0.073 12.6 4.1 0.12 11.8 1.0 2.4 2 1 0 2 2 2 0 Photosystem I reaction centre subunit XI PAP2 PF01569.16 AIC17087.1 - 0.85 9.3 16.7 0.045 13.4 7.1 2.2 2 0 0 2 2 2 0 PAP2 superfamily Gly-zipper_OmpA PF13436.1 AIC17087.1 - 3 7.5 9.5 1.5 8.5 2.6 2.7 2 1 1 3 3 3 0 Glycine-zipper containing OmpA-like membrane domain Rieske PF00355.21 AIC17088.1 - 1.9e-10 40.1 0.0 3.1e-10 39.4 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain FMN_red PF03358.10 AIC17088.1 - 6.4e-06 25.7 0.0 8e-06 25.4 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Rieske_2 PF13806.1 AIC17088.1 - 0.047 13.4 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 Rieske-like [2Fe-2S] domain Rieske PF00355.21 AIC17090.1 - 9.5e-14 50.7 0.0 1e-13 50.6 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 AIC17090.1 - 2.7e-07 30.2 0.0 3.3e-07 29.9 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Tautomerase PF01361.16 AIC17091.1 - 1.3e-13 50.2 0.1 1.7e-13 49.9 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.1 AIC17091.1 - 5.2e-08 32.8 0.1 5.7e-08 32.6 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme DUF3040 PF11239.3 AIC17092.1 - 8.1 6.5 7.6 4.4 7.4 2.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Peptidase_M20 PF01546.23 AIC17093.1 - 1e-30 106.6 0.0 1.6e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.9 AIC17093.1 - 2.2e-15 56.3 0.0 4e-15 55.5 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Amidohydro_2 PF04909.9 AIC17093.1 - 0.11 12.1 0.1 0.17 11.3 0.1 1.2 1 0 0 1 1 1 0 Amidohydrolase DUF326 PF03860.11 AIC17094.1 - 5.6e-10 38.4 51.6 0.0017 18.0 1.7 4.1 4 0 0 4 4 4 4 Domain of Unknown Function (DUF326) CD20 PF04103.10 AIC17094.1 - 1.2 9.0 5.1 1.5 8.7 3.5 1.1 1 0 0 1 1 1 0 CD20-like family Pox_P35 PF03213.9 AIC17094.1 - 2.1 7.2 6.4 2.3 7.1 4.4 1.1 1 0 0 1 1 1 0 Poxvirus P35 protein zf-C2H2 PF00096.21 AIC17095.1 - 2.1e-05 24.5 2.7 3.1e-05 24.0 1.9 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.1 AIC17095.1 - 0.00015 21.8 0.5 0.00023 21.2 0.3 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_5 PF13909.1 AIC17095.1 - 0.014 15.5 0.7 0.026 14.7 0.5 1.5 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_6 PF13912.1 AIC17095.1 - 0.094 12.6 0.6 0.14 12.1 0.4 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger ParA PF10609.4 AIC17095.1 - 0.13 12.1 0.1 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 ParA/MinD ATPase like zf-H2C2_2 PF13465.1 AIC17095.1 - 0.23 11.8 3.6 2.9 8.3 0.0 2.3 2 0 0 2 2 2 0 Zinc-finger double domain LEA_2 PF03168.8 AIC17097.1 - 2.9e-05 24.3 0.0 4.9e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Late embryogenesis abundant protein Polyketide_cyc2 PF10604.4 AIC17098.1 - 0.0026 17.9 1.1 0.0034 17.5 0.7 1.2 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport TrmB PF01978.14 AIC17099.1 - 3.2e-10 39.5 0.1 7.6e-10 38.3 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Penicillinase_R PF03965.11 AIC17099.1 - 0.065 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Penicillinase repressor PadR PF03551.9 AIC17099.1 - 0.067 12.9 0.0 0.25 11.1 0.0 2.0 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family FUR PF01475.14 AIC17099.1 - 0.15 12.0 0.0 0.43 10.5 0.0 1.7 2 0 0 2 2 2 0 Ferric uptake regulator family Aldo_ket_red PF00248.16 AIC17100.1 - 4.5e-50 170.0 0.0 5.1e-50 169.8 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF3493 PF11998.3 AIC17102.1 - 0.14 12.0 1.5 1.1 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3493) tRNA-synt_1b PF00579.20 AIC17103.1 - 1.7e-39 135.7 0.0 4e-39 134.4 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF45 PF01863.12 AIC17104.1 - 2.8e-56 190.5 1.0 3.3e-56 190.3 0.7 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.5 AIC17104.1 - 5.8e-07 29.5 0.1 1.1e-06 28.6 0.1 1.4 1 0 0 1 1 1 1 WLM domain SprT-like PF10263.4 AIC17104.1 - 0.025 14.2 0.1 0.044 13.4 0.0 1.5 1 0 0 1 1 1 0 SprT-like family HSV_VP16_C PF12149.3 AIC17106.1 - 0.046 13.3 0.1 0.12 12.0 0.1 1.7 1 0 0 1 1 1 0 Herpes simplex virus virion protein 16 C terminal PB1 PF00564.19 AIC17106.1 - 0.079 12.6 0.1 4.8 6.9 0.0 2.3 2 0 0 2 2 2 0 PB1 domain TP6A_N PF04406.9 AIC17107.1 - 3.3e-13 49.0 0.0 6.4e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase DUF2399 PF09664.5 AIC17107.1 - 0.026 14.4 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) Topo-VIb_trans PF09239.6 AIC17108.1 - 2.5e-34 118.1 0.1 9e-31 106.5 0.0 2.6 1 1 1 2 2 2 2 Topoisomerase VI B subunit, transducer HATPase_c PF02518.21 AIC17108.1 - 1.6e-10 40.6 0.0 4.3e-10 39.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.1 AIC17108.1 - 2.4e-08 33.6 0.0 9.9e-08 31.7 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF708 PF05341.6 AIC17108.1 - 0.042 13.6 0.1 5.9 6.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF708) Rod_cone_degen PF15201.1 AIC17109.1 - 0.047 13.5 0.0 0.074 12.9 0.0 1.4 1 0 0 1 1 1 0 Progressive rod-cone degeneration DUF3237 PF11578.3 AIC17109.1 - 0.057 12.7 0.0 0.061 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3237) PQ-loop PF04193.9 AIC17110.1 - 8.8e-10 37.9 1.8 1.1e-09 37.6 0.4 1.8 1 1 1 2 2 2 1 PQ loop repeat MtN3_slv PF03083.11 AIC17110.1 - 3e-07 30.2 0.9 4e-07 29.8 0.6 1.3 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange LAB_N PF07578.6 AIC17110.1 - 0.009 15.9 0.3 0.014 15.3 0.2 1.3 1 0 0 1 1 1 1 Lipid A Biosynthesis N-terminal domain FtsX PF02687.16 AIC17110.1 - 0.024 14.4 1.7 0.032 13.9 1.2 1.2 1 0 0 1 1 1 0 FtsX-like permease family Rieske PF00355.21 AIC17111.1 - 0.07 12.7 1.2 0.082 12.4 0.8 1.2 1 0 0 1 1 1 0 Rieske [2Fe-2S] domain DHO_dh PF01180.16 AIC17113.1 - 2.6e-35 121.8 0.0 3.2e-35 121.5 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase FMN_dh PF01070.13 AIC17113.1 - 0.016 14.1 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 FMN-dependent dehydrogenase NMO PF03060.10 AIC17113.1 - 0.019 14.0 0.0 0.032 13.3 0.0 1.2 1 0 0 1 1 1 0 Nitronate monooxygenase Radical_SAM PF04055.16 AIC17114.1 - 2.7e-08 34.1 0.0 6.1e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Propeptide_C25 PF08126.6 AIC17114.1 - 0.037 13.0 0.0 0.061 12.3 0.0 1.2 1 0 0 1 1 1 0 Propeptide_C25 TrbH PF07283.6 AIC17115.1 - 0.0058 16.4 0.1 0.0066 16.3 0.0 1.1 1 0 0 1 1 1 1 Conjugal transfer protein TrbH Mitofilin PF09731.4 AIC17115.1 - 0.011 14.4 0.2 0.013 14.1 0.1 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein HD PF01966.17 AIC17116.1 - 1.9e-17 63.3 0.2 3e-17 62.7 0.2 1.3 1 0 0 1 1 1 1 HD domain DUF706 PF05153.10 AIC17116.1 - 0.031 13.5 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF706) HD_4 PF13328.1 AIC17116.1 - 0.074 12.7 3.6 0.34 10.6 1.1 2.8 2 1 0 2 2 2 0 HD domain Monooxygenase_B PF04744.7 AIC17117.1 - 2.3e-09 36.4 0.1 4.8e-09 35.4 0.0 1.4 2 0 0 2 2 2 1 Monooxygenase subunit B protein tRNA_anti-like PF12869.2 AIC17117.1 - 0.017 14.6 0.3 4.2 6.8 0.2 2.5 2 1 0 2 2 2 0 tRNA_anti-like Rad51 PF08423.6 AIC17118.1 - 9.6e-92 306.5 0.4 1.3e-91 306.0 0.3 1.2 1 0 0 1 1 1 1 Rad51 AAA_25 PF13481.1 AIC17118.1 - 5.1e-12 45.6 0.0 8.2e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain RecA PF00154.16 AIC17118.1 - 2.2e-11 43.3 0.2 3.1e-11 42.9 0.1 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein KaiC PF06745.8 AIC17118.1 - 7.5e-10 38.3 0.1 1.3e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 KaiC HHH_5 PF14520.1 AIC17118.1 - 1.8e-05 24.7 0.2 6.6e-05 22.9 0.1 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cdd1 PF11731.3 AIC17118.1 - 0.005 16.7 0.0 0.011 15.6 0.0 1.5 1 0 0 1 1 1 1 Pathogenicity locus AAA_22 PF13401.1 AIC17118.1 - 0.008 16.3 0.0 0.015 15.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.22 AIC17118.1 - 0.037 14.3 0.0 0.99 9.6 0.0 2.2 2 0 0 2 2 2 0 ABC transporter DNA_pol_lambd_f PF10391.4 AIC17118.1 - 0.14 11.7 0.0 0.69 9.5 0.0 2.1 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Ribosomal_L21e PF01157.13 AIC17119.1 - 1.6e-13 50.3 1.8 1.9e-13 50.0 1.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L21e RNA_pol_Rpb4 PF03874.11 AIC17120.1 - 2e-12 47.1 0.5 4.3e-12 46.0 0.3 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb4 Bse634I PF07832.6 AIC17120.1 - 0.00056 19.1 0.2 0.00062 18.9 0.1 1.0 1 0 0 1 1 1 1 Cfr10I/Bse634I restriction endonuclease HNF-1_N PF04814.8 AIC17120.1 - 0.029 14.4 0.2 0.035 14.2 0.1 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF2624 PF11116.3 AIC17120.1 - 0.081 13.4 0.9 0.28 11.7 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2624) Vitellogenin_N PF01347.17 AIC17120.1 - 0.088 11.0 0.6 0.11 10.7 0.4 1.0 1 0 0 1 1 1 0 Lipoprotein amino terminal region Glycos_trans_3N PF02885.12 AIC17120.1 - 0.12 12.0 0.1 0.47 10.0 0.0 2.0 1 1 1 2 2 2 0 Glycosyl transferase family, helical bundle domain HTH_37 PF13744.1 AIC17120.1 - 0.13 12.0 0.4 0.4 10.5 0.0 2.0 2 1 0 2 2 2 0 Helix-turn-helix domain Vps4_C PF09336.5 AIC17120.1 - 0.14 12.0 0.4 1.5 8.7 0.0 2.3 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain DUF655 PF04919.7 AIC17121.1 - 1.6e-38 132.2 0.3 1.7e-38 132.1 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF655) HHH_6 PF14579.1 AIC17121.1 - 6.8e-06 26.0 0.0 8.7e-06 25.6 0.0 1.5 1 1 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.2 AIC17121.1 - 0.00085 19.2 0.1 0.0018 18.1 0.0 1.6 1 1 1 2 2 2 1 Helix-hairpin-helix motif Stn1_C PF12659.2 AIC17121.1 - 0.057 13.2 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Telomere capping C-terminal wHTH RrnaAD PF00398.15 AIC17122.1 - 4.4e-39 134.0 0.0 5.3e-39 133.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_26 PF13659.1 AIC17122.1 - 2.4e-08 34.0 0.0 3.8e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC17122.1 - 2.9e-07 31.0 0.0 4.5e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC17122.1 - 1.9e-05 24.2 0.0 2.7e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC17122.1 - 3.5e-05 23.2 0.0 5.8e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.14 AIC17122.1 - 0.00062 19.3 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.1 AIC17122.1 - 0.00077 19.2 0.0 0.0013 18.4 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC17122.1 - 0.0023 18.3 0.0 0.0062 17.0 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain GCD14 PF08704.5 AIC17122.1 - 0.018 14.5 0.0 0.074 12.5 0.0 1.8 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_25 PF13649.1 AIC17122.1 - 0.11 12.8 0.1 0.3 11.4 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_26 PF13659.1 AIC17123.1 - 1.1e-10 41.4 0.0 1.7e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.9 AIC17123.1 - 1.4e-10 40.8 0.0 1.8e-10 40.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_11 PF08241.7 AIC17123.1 - 2.1e-05 24.9 0.1 4e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.2 AIC17123.1 - 7.2e-05 23.3 0.1 0.00012 22.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.1 AIC17123.1 - 0.0013 19.0 0.1 0.0026 18.0 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.1 AIC17123.1 - 0.012 15.3 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Eco57I PF07669.6 AIC17123.1 - 0.013 15.8 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase Methyltransf_31 PF13847.1 AIC17123.1 - 0.015 14.8 0.0 0.019 14.5 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.7 AIC17123.1 - 0.016 15.6 0.1 0.036 14.5 0.1 1.6 1 1 0 1 1 1 0 Methyltransferase domain UPF0020 PF01170.13 AIC17123.1 - 0.052 13.1 0.0 0.13 11.8 0.0 1.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 RrnaAD PF00398.15 AIC17123.1 - 0.063 12.3 0.0 0.066 12.2 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase PrmA PF06325.8 AIC17123.1 - 0.14 11.3 0.0 0.25 10.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Iso_dh PF00180.15 AIC17124.1 - 3.1e-78 263.1 0.0 3.7e-78 262.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pox_TAA1 PF03295.9 AIC17124.1 - 0.079 12.6 0.0 0.59 9.8 0.0 2.2 2 0 0 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal Metallophos_2 PF12850.2 AIC17126.1 - 2.2e-19 69.8 0.0 2.8e-19 69.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.23 AIC17126.1 - 2.6e-18 66.1 0.2 3.7e-18 65.6 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase MutL PF13941.1 AIC17126.1 - 0.18 10.0 0.0 0.27 9.5 0.0 1.1 1 0 0 1 1 1 0 MutL protein AmoC PF04896.7 AIC17128.1 - 1.3e-16 60.4 5.3 1.6e-16 60.1 3.7 1.0 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C OAD_gamma PF04277.8 AIC17128.1 - 0.28 11.5 1.8 1.8 9.0 0.0 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain NMN_transporter PF04973.7 AIC17128.1 - 1.7 8.0 9.2 0.86 9.0 4.3 1.9 1 1 1 2 2 2 0 Nicotinamide mononucleotide transporter DUF581 PF04570.9 AIC17129.1 - 0.017 14.3 7.5 0.019 14.2 5.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF581) zf-AN1 PF01428.11 AIC17129.1 - 0.036 13.9 7.0 0.047 13.5 4.9 1.2 1 0 0 1 1 1 0 AN1-like Zinc finger zf-B_box PF00643.19 AIC17129.1 - 0.039 13.8 6.8 0.052 13.4 4.7 1.2 1 0 0 1 1 1 0 B-box zinc finger UPF1_Zn_bind PF09416.5 AIC17129.1 - 0.26 10.8 5.6 0.29 10.6 3.9 1.1 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) zf-UBP PF02148.14 AIC17129.1 - 0.43 10.7 6.3 0.58 10.3 4.4 1.3 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein Fer4_3 PF12798.2 AIC17129.1 - 0.58 10.8 4.3 4.9 7.9 0.3 2.5 2 1 0 2 2 2 0 4Fe-4S binding domain zf-RING_5 PF14634.1 AIC17129.1 - 0.62 9.8 6.2 0.7 9.6 4.3 1.2 1 0 0 1 1 1 0 zinc-RING finger domain zf-HIT PF04438.11 AIC17129.1 - 0.98 9.1 9.6 1.6 8.4 6.7 1.5 1 1 0 1 1 1 0 HIT zinc finger zf-MYND PF01753.13 AIC17129.1 - 1.4 8.8 8.4 1.9 8.4 5.8 1.3 1 0 0 1 1 1 0 MYND finger DZR PF12773.2 AIC17129.1 - 1.4 8.7 7.7 2.8 7.8 5.4 1.6 1 1 0 1 1 1 0 Double zinc ribbon DUF329 PF03884.9 AIC17129.1 - 2.7 7.5 6.6 8.9 5.9 4.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF329) C1_2 PF03107.11 AIC17129.1 - 4.7 7.4 9.2 11 6.1 6.4 1.7 1 1 0 1 1 1 0 C1 domain MacB_PCD PF12704.2 AIC17130.1 - 1.9e-28 99.6 0.9 1.9e-28 99.6 0.6 2.4 2 1 0 2 2 2 1 MacB-like periplasmic core domain FtsX PF02687.16 AIC17130.1 - 1.3e-22 79.8 6.8 1.3e-22 79.8 4.7 2.0 2 0 0 2 2 2 1 FtsX-like permease family NPCBM_assoc PF10633.4 AIC17131.1 - 8.2e-09 35.3 13.7 0.0018 18.3 0.1 5.5 4 2 0 4 4 4 4 NPCBM-associated, NEW3 domain of alpha-galactosidase Protocadherin PF08374.6 AIC17131.1 - 0.0015 18.2 0.2 0.0026 17.4 0.2 1.4 1 0 0 1 1 1 1 Protocadherin CARDB PF07705.6 AIC17131.1 - 0.0046 16.9 8.9 0.049 13.6 0.2 3.8 2 2 2 4 4 4 2 CARDB Transglut_C PF00927.17 AIC17131.1 - 0.0078 16.2 0.5 2.8 8.0 0.0 3.6 3 1 0 3 3 3 1 Transglutaminase family, C-terminal ig like domain Syndecan PF01034.15 AIC17131.1 - 0.015 14.9 0.1 0.04 13.5 0.0 1.7 1 0 0 1 1 1 0 Syndecan domain TMEM154 PF15102.1 AIC17131.1 - 0.025 14.3 0.1 0.074 12.7 0.0 1.8 1 0 0 1 1 1 0 TMEM154 protein family DUF11 PF01345.13 AIC17131.1 - 0.46 10.5 18.1 0.039 13.9 1.2 4.8 4 0 0 4 4 4 0 Domain of unknown function DUF11 ABC_tran PF00005.22 AIC17132.1 - 2.6e-34 118.4 0.0 4e-34 117.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.1 AIC17132.1 - 1.2e-14 54.9 0.2 2.9e-08 34.0 0.0 2.1 1 1 1 2 2 2 2 AAA domain SMC_N PF02463.14 AIC17132.1 - 1.6e-07 30.7 0.2 0.0037 16.5 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.1 AIC17132.1 - 5.2e-07 29.0 0.0 0.002 17.2 0.0 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.1 AIC17132.1 - 4.4e-05 22.9 0.1 8.5e-05 22.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.1 AIC17132.1 - 0.00023 21.1 0.1 0.00031 20.7 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain DUF258 PF03193.11 AIC17132.1 - 0.00034 19.8 0.1 0.00055 19.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF258 AAA_22 PF13401.1 AIC17132.1 - 0.00036 20.6 0.1 0.002 18.2 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.1 AIC17132.1 - 0.00099 19.9 0.0 0.0019 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_10 PF12846.2 AIC17132.1 - 0.001 18.5 0.1 0.0044 16.4 0.0 1.9 2 0 0 2 2 2 1 AAA-like domain MMR_HSR1 PF01926.18 AIC17132.1 - 0.0012 18.7 0.4 0.003 17.4 0.3 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_23 PF13476.1 AIC17132.1 - 0.0027 18.0 0.1 0.0043 17.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AIC17132.1 - 0.0031 16.9 0.0 0.01 15.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Arch_ATPase PF01637.13 AIC17132.1 - 0.0044 16.7 0.0 0.007 16.0 0.0 1.4 1 0 0 1 1 1 1 Archaeal ATPase AAA_33 PF13671.1 AIC17132.1 - 0.007 16.2 0.2 0.02 14.7 0.2 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.1 AIC17132.1 - 0.01 16.1 0.0 0.024 14.9 0.0 1.6 2 0 0 2 2 1 0 AAA domain MobB PF03205.9 AIC17132.1 - 0.012 15.2 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B IstB_IS21 PF01695.12 AIC17132.1 - 0.013 14.9 0.0 0.46 9.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.7 AIC17132.1 - 0.014 15.0 0.0 0.081 12.5 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.1 AIC17132.1 - 0.015 14.8 0.2 0.033 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.1 AIC17132.1 - 0.017 14.8 0.2 0.047 13.4 0.1 1.7 1 0 0 1 1 1 0 Part of AAA domain G-alpha PF00503.15 AIC17132.1 - 0.023 13.3 0.0 0.023 13.3 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_14 PF13173.1 AIC17132.1 - 0.032 14.1 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SE PF00437.15 AIC17132.1 - 0.061 12.2 0.1 0.097 11.5 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Dynamin_N PF00350.18 AIC17132.1 - 0.062 13.1 0.3 0.92 9.3 0.1 2.1 2 0 0 2 2 2 0 Dynamin family ABC_ATPase PF09818.4 AIC17132.1 - 0.063 11.8 0.5 0.21 10.1 0.1 1.9 3 0 0 3 3 3 0 Predicted ATPase of the ABC class RNA12 PF10443.4 AIC17132.1 - 0.1 11.0 0.0 0.12 10.8 0.0 1.2 1 0 0 1 1 1 0 RNA12 protein NB-ARC PF00931.17 AIC17132.1 - 0.11 11.3 0.0 0.17 10.7 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.10 AIC17132.1 - 0.11 12.1 0.2 3.1 7.4 0.0 2.4 2 1 0 2 2 2 0 NTPase AAA_28 PF13521.1 AIC17132.1 - 0.12 12.3 0.1 0.22 11.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain YHS PF04945.8 AIC17133.1 - 2.7e-12 46.3 0.7 3.3e-12 46.0 0.5 1.1 1 0 0 1 1 1 1 YHS domain Arc_trans_TRASH PF08394.5 AIC17133.1 - 3.6e-06 27.0 1.3 4.4e-06 26.7 0.9 1.1 1 0 0 1 1 1 1 Archaeal TRASH domain ATPase-cat_bd PF12156.3 AIC17133.1 - 2.6e-05 24.6 1.5 3.2e-05 24.3 1.1 1.0 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase CAP_GLY PF01302.20 AIC17133.1 - 0.022 14.4 0.0 0.027 14.1 0.0 1.2 1 0 0 1 1 1 0 CAP-Gly domain zf-FCS PF06467.9 AIC17133.1 - 0.027 14.0 1.1 0.031 13.9 0.7 1.3 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Lactamase_B_4 PF13691.1 AIC17133.1 - 0.059 12.8 0.1 0.064 12.7 0.0 1.1 1 0 0 1 1 1 0 tRNase Z endonuclease Ta0938 PF11494.3 AIC17133.1 - 0.098 12.7 0.2 0.098 12.7 0.1 1.1 1 0 0 1 1 1 0 Ta0938 YwqJ-deaminase PF14431.1 AIC17133.1 - 0.15 11.8 0.4 0.17 11.7 0.3 1.1 1 0 0 1 1 1 0 YwqJ-like deaminase zf-H2C2_2 PF13465.1 AIC17133.1 - 0.8 10.1 3.8 1.3 9.4 2.6 1.4 1 0 0 1 1 1 0 Zinc-finger double domain Asn_synthase PF00733.16 AIC17134.1 - 6e-33 114.4 0.3 1e-31 110.3 0.2 2.0 1 1 0 1 1 1 1 Asparagine synthase Arginosuc_synth PF00764.14 AIC17134.1 - 0.015 14.3 0.0 0.021 13.8 0.0 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase NAD_synthase PF02540.12 AIC17134.1 - 0.14 10.9 0.0 0.22 10.3 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Glyoxalase_4 PF13669.1 AIC17135.1 - 6.8e-23 80.7 0.0 8e-23 80.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.20 AIC17135.1 - 1.5e-13 50.7 0.0 1.8e-13 50.5 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.1 AIC17135.1 - 4e-08 33.3 0.0 4.5e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_2 PF12681.2 AIC17135.1 - 2.3e-07 31.3 0.0 3e-07 31.0 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Fucose_iso_C PF02952.12 AIC17135.1 - 0.033 13.7 0.1 1.7 8.1 0.0 2.1 2 0 0 2 2 2 0 L-fucose isomerase, C-terminal domain MM_CoA_mutase PF01642.17 AIC17136.1 - 5.5e-198 658.2 0.0 6.3e-198 658.0 0.0 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase PAP_PilO PF06864.7 AIC17136.1 - 0.016 13.5 0.0 0.033 12.5 0.0 1.4 2 0 0 2 2 2 0 Pilin accessory protein (PilO) bact-PGI_C PF10432.4 AIC17136.1 - 0.036 13.7 0.9 0.25 11.0 0.1 2.6 2 0 0 2 2 2 0 Bacterial phospho-glucose isomerase C-terminal region ELFV_dehydrog_N PF02812.13 AIC17136.1 - 0.082 12.4 0.0 0.28 10.7 0.0 1.9 1 1 1 2 2 2 0 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ArgK PF03308.11 AIC17137.1 - 5.8e-85 284.2 3.6 7.3e-85 283.9 2.5 1.0 1 0 0 1 1 1 1 ArgK protein CbiA PF01656.18 AIC17137.1 - 1.3e-06 28.0 0.3 2.4e-06 27.0 0.1 1.5 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.12 AIC17137.1 - 1.4e-05 24.7 0.0 0.023 14.2 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein cobW PF02492.14 AIC17137.1 - 0.00024 20.5 0.6 0.0011 18.3 0.4 2.0 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MobB PF03205.9 AIC17137.1 - 0.00087 19.0 0.0 0.01 15.5 0.0 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.22 AIC17137.1 - 0.00096 18.6 0.0 0.0071 15.7 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF258 PF03193.11 AIC17137.1 - 0.0018 17.4 0.0 0.005 16.0 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function, DUF258 AAA_30 PF13604.1 AIC17137.1 - 0.011 15.2 0.0 0.062 12.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain PIF1 PF05970.9 AIC17137.1 - 0.026 13.4 0.1 0.055 12.4 0.0 1.5 2 0 0 2 2 2 0 PIF1-like helicase AAA_16 PF13191.1 AIC17137.1 - 0.031 14.2 0.0 0.06 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.22 AIC17137.1 - 0.034 14.4 0.4 0.095 12.9 0.0 1.9 2 0 0 2 2 2 0 ABC transporter AAA_10 PF12846.2 AIC17137.1 - 0.039 13.3 0.2 0.096 12.1 0.1 1.7 2 0 0 2 2 2 0 AAA-like domain Ins_allergen_rp PF06757.8 AIC17137.1 - 0.064 12.7 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification MMR_HSR1 PF01926.18 AIC17137.1 - 0.065 13.1 0.4 0.54 10.2 0.3 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Troponin PF00992.15 AIC17137.1 - 0.076 13.0 3.0 0.16 12.0 2.1 1.4 1 0 0 1 1 1 0 Troponin SUA5 PF03481.8 AIC17137.1 - 0.089 12.8 0.0 0.33 11.0 0.0 1.9 2 0 0 2 2 2 0 Putative GTP-binding controlling metal-binding ArsA_ATPase PF02374.10 AIC17137.1 - 0.11 11.5 2.7 0.55 9.2 0.3 2.3 2 0 0 2 2 2 0 Anion-transporting ATPase NOG1 PF06858.9 AIC17138.1 - 0.15 11.9 0.6 0.43 10.4 0.1 1.8 1 1 1 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) DUF761 PF05553.6 AIC17138.1 - 1.2 8.5 4.1 0.69 9.3 1.0 1.9 2 1 0 2 2 2 0 Cotton fibre expressed protein B12-binding PF02310.14 AIC17139.1 - 3.9e-17 62.2 0.0 4.8e-17 61.9 0.0 1.1 1 0 0 1 1 1 1 B12 binding domain Ocnus PF05005.10 AIC17139.1 - 0.022 14.6 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 Janus/Ocnus family (Ocnus) IlvN PF07991.7 AIC17140.1 - 6.9e-69 230.4 0.7 9.5e-69 229.9 0.5 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain IlvC PF01450.14 AIC17140.1 - 8.3e-51 171.7 0.1 1.3e-50 171.0 0.1 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain NAD_binding_2 PF03446.10 AIC17140.1 - 4.8e-07 29.7 0.4 9e-07 28.8 0.3 1.4 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.14 AIC17140.1 - 9e-07 28.2 0.1 1.6e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain F420_oxidored PF03807.12 AIC17140.1 - 3e-05 24.3 0.7 6.3e-05 23.3 0.5 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.16 AIC17140.1 - 0.0082 15.9 0.1 0.015 15.1 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Phage_int_SAM_3 PF14659.1 AIC17140.1 - 0.14 12.4 0.1 0.4 10.9 0.1 1.8 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Usp PF00582.21 AIC17141.1 - 9.5e-30 103.6 0.2 1.1e-29 103.4 0.2 1.0 1 0 0 1 1 1 1 Universal stress protein family PGM_PMM_I PF02878.11 AIC17141.1 - 0.0082 15.6 0.1 0.12 11.8 0.0 2.1 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I Tox-PL-2 PF15643.1 AIC17141.1 - 0.0086 16.0 0.4 0.019 14.9 0.1 1.7 1 1 1 2 2 2 1 Papain fold toxin 2 HPP PF04982.8 AIC17142.1 - 6.3e-34 116.3 12.4 1.1e-33 115.6 8.6 1.4 1 0 0 1 1 1 1 HPP family UbiA PF01040.13 AIC17142.1 - 0.041 13.0 22.8 0.99 8.5 15.8 2.0 1 1 0 1 1 1 0 UbiA prenyltransferase family Ferric_reduct PF01794.14 AIC17142.1 - 0.24 11.4 4.4 0.35 10.9 2.8 1.6 1 1 0 1 1 1 0 Ferric reductase like transmembrane component Yip1 PF04893.12 AIC17143.1 - 0.00016 21.2 23.2 0.00025 20.5 16.1 1.3 1 0 0 1 1 1 1 Yip1 domain DUF360 PF04020.8 AIC17143.1 - 0.0006 20.1 15.9 0.006 16.9 2.5 2.2 1 1 1 2 2 2 2 Membrane protein of unknown function Peptidase_U4 PF03419.8 AIC17143.1 - 0.66 9.0 7.4 1 8.3 5.1 1.4 1 1 0 1 1 1 0 Sporulation factor SpoIIGA MFS_2 PF13347.1 AIC17143.1 - 3.6 5.8 14.8 6.4 5.0 10.0 1.6 1 1 0 1 1 1 0 MFS/sugar transport protein DUF973 PF06157.6 AIC17143.1 - 6.5 5.6 13.4 7.5 5.4 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF973) HisKA_3 PF07730.8 AIC17144.1 - 2.5e-05 24.5 3.8 0.0016 18.7 0.1 3.2 1 1 1 2 2 2 1 Histidine kinase DUF883 PF05957.8 AIC17144.1 - 0.00091 19.5 5.6 0.088 13.2 0.2 2.3 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF883) WXG100 PF06013.7 AIC17144.1 - 0.014 15.3 6.7 3.1 7.8 2.7 3.6 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Laminin_II PF06009.7 AIC17144.1 - 0.022 14.5 9.5 0.3 10.8 3.9 2.3 1 1 1 2 2 2 0 Laminin Domain II TMP_2 PF06791.8 AIC17144.1 - 0.024 14.2 9.7 0.91 9.1 6.7 2.0 1 1 0 1 1 1 0 Prophage tail length tape measure protein DUF4559 PF15112.1 AIC17144.1 - 0.044 12.9 2.1 0.053 12.6 1.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4559) YtxH PF12732.2 AIC17144.1 - 0.086 13.2 13.8 2.1e+03 -0.9 9.5 3.2 1 1 0 1 1 1 0 YtxH-like protein DUF3141 PF11339.3 AIC17144.1 - 0.11 10.8 0.3 0.13 10.5 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) Pox_H7 PF04787.7 AIC17144.1 - 0.11 12.3 1.4 0.18 11.6 0.3 1.7 1 1 0 1 1 1 0 Late protein H7 DUF2250 PF10007.4 AIC17144.1 - 0.11 12.3 1.4 2.7 7.9 0.0 2.7 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) Relaxase PF03432.9 AIC17144.1 - 0.12 11.7 3.0 0.18 11.2 2.1 1.4 1 1 0 1 1 1 0 Relaxase/Mobilisation nuclease domain RmuC PF02646.11 AIC17144.1 - 0.12 11.2 5.1 0.2 10.4 0.9 2.2 1 1 1 2 2 2 0 RmuC family Syntaxin-6_N PF09177.6 AIC17144.1 - 0.17 12.2 5.3 1.9 8.9 0.4 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal MCPsignal PF00015.16 AIC17144.1 - 0.2 11.1 13.2 3.2 7.2 9.2 2.1 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Chlorosome_CsmC PF11098.3 AIC17144.1 - 0.2 11.3 3.9 0.66 9.6 2.7 1.9 1 1 0 1 1 1 0 Chlorosome envelope protein C Spectrin PF00435.16 AIC17144.1 - 0.25 11.6 2.5 13 6.1 0.2 2.3 1 1 1 2 2 2 0 Spectrin repeat Prominin PF05478.6 AIC17144.1 - 0.32 8.4 4.4 0.67 7.4 3.0 1.5 1 1 0 1 1 1 0 Prominin Syntaxin_2 PF14523.1 AIC17144.1 - 0.33 11.0 5.0 6.8 6.7 3.4 2.6 1 1 0 1 1 1 0 Syntaxin-like protein Effector_1 PF04518.7 AIC17144.1 - 0.33 9.8 5.4 0.28 10.1 3.1 1.4 1 1 0 1 1 1 0 Effector from type III secretion system DUF1664 PF07889.7 AIC17144.1 - 0.46 10.2 7.2 3.4 7.4 2.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMPIT PF07851.8 AIC17144.1 - 0.53 9.3 3.3 2.7 6.9 0.6 2.0 1 1 0 2 2 2 0 TMPIT-like protein UPF0181 PF03701.9 AIC17144.1 - 0.55 9.5 4.0 0.19 11.0 0.4 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) DUF2203 PF09969.4 AIC17144.1 - 0.81 9.9 5.7 6.6 6.9 1.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) H-kinase_dim PF02895.9 AIC17144.1 - 1.3 9.4 3.9 27 5.2 2.7 2.7 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain DUF948 PF06103.6 AIC17144.1 - 2.8 7.8 9.4 15 5.5 4.6 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) FlgN PF05130.7 AIC17144.1 - 3.2 7.9 7.3 8.3 6.6 2.3 2.1 1 1 1 2 2 2 0 FlgN protein Seryl_tRNA_N PF02403.17 AIC17144.1 - 3.5 7.6 9.6 7.9 6.5 4.2 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Syntaxin PF00804.20 AIC17144.1 - 5.5 7.2 9.8 3e+02 1.6 6.9 2.6 1 1 0 1 1 1 0 Syntaxin ADK_lid PF05191.9 AIC17146.1 - 0.14 11.8 2.3 0.2 11.3 1.0 1.7 2 0 0 2 2 2 0 Adenylate kinase, active site lid HTH_5 PF01022.15 AIC17147.1 - 1.2e-14 53.6 0.7 2.5e-14 52.6 0.5 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.2 AIC17147.1 - 1e-13 50.8 1.3 1.7e-13 50.1 0.9 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.2 AIC17147.1 - 8e-09 35.0 0.1 1.4e-08 34.2 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.1 AIC17147.1 - 1.1e-07 31.1 0.2 2e-07 30.2 0.1 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.7 AIC17147.1 - 2.2e-05 24.0 0.4 4.6e-05 22.9 0.3 1.6 1 0 0 1 1 1 1 HTH domain MarR PF01047.17 AIC17147.1 - 6e-05 22.6 0.4 0.00013 21.6 0.2 1.5 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.1 AIC17147.1 - 0.00013 21.9 0.1 0.00024 21.0 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain TFIIE_alpha PF02002.12 AIC17147.1 - 0.0004 19.8 0.3 0.00088 18.7 0.1 1.6 2 0 0 2 2 2 1 TFIIE alpha subunit HTH_IclR PF09339.5 AIC17147.1 - 0.0012 18.3 0.6 0.0026 17.2 0.4 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_10 PF04967.7 AIC17147.1 - 0.0014 18.1 0.1 0.0035 16.8 0.0 1.7 1 0 0 1 1 1 1 HTH DNA binding domain HTH_Crp_2 PF13545.1 AIC17147.1 - 0.0015 18.3 0.2 0.003 17.3 0.2 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TrmB PF01978.14 AIC17147.1 - 0.0032 17.1 0.0 0.0058 16.3 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.1 AIC17147.1 - 0.0037 17.5 1.1 0.0049 17.1 0.1 1.7 2 0 0 2 2 1 1 Winged helix DNA-binding domain UPF0172 PF03665.8 AIC17147.1 - 0.0039 16.7 0.0 0.0058 16.1 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Sigma70_r4 PF04545.11 AIC17147.1 - 0.0055 15.9 0.0 0.012 14.8 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 Fe_dep_repress PF01325.14 AIC17147.1 - 0.0078 16.1 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_23 PF13384.1 AIC17147.1 - 0.0082 15.7 0.1 0.018 14.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain HTH_26 PF13443.1 AIC17147.1 - 0.0083 16.3 0.2 0.019 15.1 0.1 1.6 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain HTH_3 PF01381.17 AIC17147.1 - 0.0098 15.7 0.0 0.02 14.6 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix HTH_Tnp_ISL3 PF13542.1 AIC17147.1 - 0.01 14.9 0.3 0.026 13.7 0.2 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 Rrf2 PF02082.15 AIC17147.1 - 0.011 15.8 0.2 0.02 15.0 0.2 1.4 1 0 0 1 1 1 0 Transcriptional regulator KorB PF08535.5 AIC17147.1 - 0.026 14.6 0.0 0.054 13.6 0.0 1.6 1 0 0 1 1 1 0 KorB domain HTH_AsnC-type PF13404.1 AIC17147.1 - 0.038 13.5 0.1 0.067 12.7 0.1 1.5 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain HTH_36 PF13730.1 AIC17147.1 - 0.05 13.7 0.0 0.26 11.4 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_28 PF13518.1 AIC17147.1 - 0.079 12.9 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_45 PF14947.1 AIC17147.1 - 0.08 12.7 0.1 0.16 11.8 0.1 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix HTH_15 PF12324.3 AIC17147.1 - 0.085 12.5 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain of alkylmercury lyase CUT PF02376.10 AIC17147.1 - 0.094 12.5 0.3 2.5 7.9 0.0 2.3 1 1 1 2 2 2 0 CUT domain HxlR PF01638.12 AIC17147.1 - 0.11 12.1 0.5 0.18 11.4 0.4 1.3 1 0 0 1 1 1 0 HxlR-like helix-turn-helix HTH_38 PF13936.1 AIC17147.1 - 0.13 11.8 0.5 0.28 10.7 0.2 1.7 2 0 0 2 2 1 0 Helix-turn-helix domain Translin PF01997.11 AIC17148.1 - 0.005 16.4 6.9 0.02 14.5 0.3 2.2 2 0 0 2 2 2 1 Translin family Prominin PF05478.6 AIC17148.1 - 0.011 13.2 3.4 0.014 12.9 0.1 1.9 2 0 0 2 2 2 0 Prominin DUF2666 PF10869.3 AIC17148.1 - 0.029 14.3 5.2 0.065 13.2 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2666) BAR PF03114.13 AIC17148.1 - 0.033 13.6 2.8 0.06 12.8 1.9 1.5 1 1 1 2 2 2 0 BAR domain TBPIP PF07106.8 AIC17148.1 - 0.042 13.4 8.2 0.024 14.1 0.9 2.2 2 0 0 2 2 2 0 Tat binding protein 1(TBP-1)-interacting protein (TBPIP) HisKA PF00512.20 AIC17148.1 - 0.067 13.1 2.3 1 9.4 0.0 3.0 1 1 1 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF885 PF05960.6 AIC17148.1 - 0.094 11.8 0.8 0.27 10.3 0.1 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF885) Imm3 PF14425.1 AIC17148.1 - 0.2 11.6 2.0 0.59 10.1 0.3 2.1 2 0 0 2 2 2 0 Immunity protein Imm3 DUF241 PF03087.9 AIC17148.1 - 0.2 11.1 6.3 0.65 9.4 0.2 2.2 2 0 0 2 2 2 0 Arabidopsis protein of unknown function Erp_C PF06780.6 AIC17148.1 - 0.27 11.0 5.5 0.23 11.3 0.2 2.6 1 1 1 2 2 2 0 Erp protein C-terminus WXG100 PF06013.7 AIC17148.1 - 0.32 11.0 2.0 12 6.0 0.1 3.5 1 1 2 4 4 4 0 Proteins of 100 residues with WXG Sec8_exocyst PF04048.9 AIC17148.1 - 0.42 10.2 7.5 4.9 6.7 0.7 2.9 2 2 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF892 PF05974.7 AIC17148.1 - 0.55 10.0 4.5 1 9.1 0.3 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF892) DUF1664 PF07889.7 AIC17148.1 - 1.1 9.0 5.9 3.2 7.5 0.4 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4533 PF15047.1 AIC17148.1 - 1.1 8.5 8.2 0.066 12.6 0.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4533) eIF3_N PF09440.5 AIC17148.1 - 1.2 9.3 4.9 0.48 10.5 0.5 2.2 2 1 0 2 2 2 0 eIF3 subunit 6 N terminal domain DUF2203 PF09969.4 AIC17148.1 - 2.8 8.1 6.2 1.9 8.7 0.7 2.4 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Ferritin PF00210.19 AIC17150.1 - 1e-27 96.6 1.5 1.3e-27 96.3 1.1 1.1 1 0 0 1 1 1 1 Ferritin-like domain CorA PF01544.13 AIC17150.1 - 0.13 11.3 1.1 0.61 9.0 0.1 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Orthopox_F14 PF06076.7 AIC17150.1 - 0.13 12.3 0.2 8.4 6.5 0.0 2.5 2 0 0 2 2 2 0 Orthopoxvirus F14 protein DUF4191 PF13829.1 AIC17151.1 - 0.011 14.8 0.5 0.012 14.7 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF368 PF04018.8 AIC17151.1 - 0.015 14.4 1.0 0.015 14.4 0.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF368) DUF4131 PF13567.1 AIC17151.1 - 0.028 13.8 0.5 0.032 13.6 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) HAP PF03866.8 AIC17151.1 - 0.073 12.8 1.8 0.087 12.6 1.2 1.1 1 0 0 1 1 1 0 Hydrophobic abundant protein (HAP) FUSC_2 PF13515.1 AIC17151.1 - 0.074 12.9 2.1 0.088 12.7 1.5 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein-like Picorna_P3A PF06363.6 AIC17151.1 - 0.42 10.6 2.5 3.5 7.6 0.3 2.0 1 1 1 2 2 2 0 Picornaviridae P3A protein DUF4282 PF14110.1 AIC17151.1 - 1.7 8.9 7.9 2.7 8.2 5.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4282) Spermine_synth PF01564.12 AIC17152.1 - 6.3e-10 38.4 0.0 9.9e-10 37.7 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase Methyltransf_26 PF13659.1 AIC17152.1 - 0.00019 21.4 0.0 0.0011 18.9 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC17152.1 - 0.01 16.2 0.0 0.028 14.9 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain DUF3974 PF13120.1 AIC17152.1 - 0.4 10.5 1.9 19 5.0 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3974) PLDc_2 PF13091.1 AIC17154.1 - 8.7e-05 22.2 0.2 0.088 12.5 0.1 2.6 2 1 0 2 2 2 2 PLD-like domain MinC_C PF03775.11 AIC17154.1 - 0.014 15.0 0.0 0.036 13.6 0.0 1.7 1 0 0 1 1 1 0 Septum formation inhibitor MinC, C-terminal domain DUF4242 PF14026.1 AIC17155.1 - 2.9e-11 43.2 0.0 4.8e-11 42.5 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4242) DUF2795 PF11387.3 AIC17156.1 - 8.2e-05 22.3 0.0 0.00025 20.8 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2795) Pyridox_oxidase PF01243.15 AIC17158.1 - 6.3e-15 54.9 0.0 8.9e-15 54.4 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.2 AIC17158.1 - 2.8e-07 30.4 0.0 3.4e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Rieske PF00355.21 AIC17159.1 - 6.1e-14 51.3 0.0 7.1e-14 51.1 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 AIC17159.1 - 7.7e-07 28.7 0.0 9.5e-07 28.4 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Antitoxin-MazE PF04014.13 AIC17159.1 - 0.039 13.6 0.2 0.061 13.0 0.1 1.3 1 0 0 1 1 1 0 Antidote-toxin recognition MazE Flagellin_D3 PF08884.6 AIC17159.1 - 0.18 11.9 1.3 0.25 11.5 0.3 1.6 2 0 0 2 2 2 0 Flagellin D3 domain Acetyltransf_1 PF00583.19 AIC17160.1 - 1e-10 41.4 0.0 1.5e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.1 AIC17160.1 - 6.6e-07 29.4 0.0 1e-06 28.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.1 AIC17160.1 - 3.6e-05 23.8 0.0 6.2e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.1 AIC17160.1 - 7.1e-05 22.6 0.0 0.00014 21.6 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.5 AIC17160.1 - 0.00025 20.7 0.0 0.00046 19.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.1 AIC17160.1 - 0.0055 16.5 0.0 0.0063 16.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.1 AIC17160.1 - 0.022 14.6 0.0 0.033 14.0 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase 3-dmu-9_3-mt PF06983.8 AIC17162.1 - 8.7e-45 151.7 0.1 1.3e-44 151.2 0.1 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase AHSA1 PF08327.6 AIC17163.1 - 1.8e-24 86.2 1.2 2.1e-24 86.0 0.8 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.4 AIC17163.1 - 3.1e-06 27.4 0.8 5e-06 26.7 0.5 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.15 AIC17163.1 - 0.031 14.2 0.2 0.041 13.8 0.2 1.5 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport Mfa2 PF08842.5 AIC17165.1 - 0.023 14.0 0.1 0.029 13.7 0.1 1.2 1 0 0 1 1 1 0 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2 DUF4199 PF13858.1 AIC17165.1 - 0.097 12.5 0.1 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) HNH_5 PF14279.1 AIC17167.1 - 0.0022 17.9 0.0 0.0044 16.9 0.0 1.6 1 0 0 1 1 1 1 HNH endonuclease PsbQ PF05757.6 AIC17168.1 - 0.00043 19.7 0.1 0.00053 19.4 0.1 1.1 1 0 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) CAT_RBD PF03123.10 AIC17169.1 - 0.13 12.0 1.2 0.94 9.2 0.3 2.1 2 0 0 2 2 2 0 CAT RNA binding domain zf-CHCC PF10276.4 AIC17171.1 - 0.025 14.3 0.4 0.046 13.5 0.3 1.4 1 0 0 1 1 1 0 Zinc-finger domain Prok-RING_4 PF14447.1 AIC17171.1 - 0.07 12.6 0.2 0.098 12.2 0.1 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-H2C2_2 PF13465.1 AIC17171.1 - 0.35 11.2 0.5 0.35 11.2 0.4 1.7 2 0 0 2 2 2 0 Zinc-finger double domain TPR_3 PF07720.7 AIC17172.1 - 3.5 7.5 6.7 1.5 8.7 1.8 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat Baculo_19 PF04798.7 AIC17173.1 - 0.1 11.9 0.0 4.5 6.6 0.0 2.1 1 1 1 2 2 2 0 Baculovirus 19 kDa protein conserved region AT_hook PF02178.14 AIC17173.1 - 0.37 10.6 3.7 1 9.2 2.6 1.8 1 0 0 1 1 1 0 AT hook motif Phage_integrase PF00589.17 AIC17174.1 - 1.5e-05 24.7 0.0 0.0003 20.5 0.0 2.4 1 1 0 1 1 1 1 Phage integrase family HTH_38 PF13936.1 AIC17174.1 - 0.00055 19.4 1.3 0.0018 17.8 0.2 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_24 PF13412.1 AIC17174.1 - 0.086 12.2 0.0 0.25 10.7 0.0 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding N6_N4_Mtase PF01555.13 AIC17176.1 - 3e-44 151.2 0.1 3.7e-43 147.6 0.1 2.0 1 1 0 1 1 1 1 DNA methylase Methyltransf_26 PF13659.1 AIC17176.1 - 9.6e-09 35.2 0.0 0.0046 16.9 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain UPF0020 PF01170.13 AIC17176.1 - 5.6e-07 29.3 0.0 0.00011 21.8 0.0 2.4 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 MTS PF05175.9 AIC17176.1 - 0.0021 17.4 0.0 0.053 12.8 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_15 PF09445.5 AIC17176.1 - 0.12 11.9 0.1 2.9 7.4 0.0 2.7 3 0 0 3 3 3 0 RNA cap guanine-N2 methyltransferase DUF1874 PF08960.5 AIC17179.1 - 0.066 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1874) HNH PF01844.18 AIC17181.1 - 0.12 12.2 2.1 0.24 11.2 1.5 1.5 1 0 0 1 1 1 0 HNH endonuclease 2H-phosphodiest PF08975.5 AIC17185.1 - 0.072 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1868) DUF1764 PF08576.5 AIC17185.1 - 0.13 13.0 3.2 0.51 11.1 2.2 2.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) HEPN PF05168.9 AIC17186.1 - 1.6e-10 40.8 0.6 4.9e-10 39.3 0.4 1.8 1 1 0 1 1 1 1 HEPN domain RelB_N PF12910.2 AIC17186.1 - 0.018 14.4 0.1 16 4.9 0.0 3.3 3 0 0 3 3 3 0 Antitoxin of toxin-antitoxin stability system N-terminal PhdYeFM_antitox PF02604.14 AIC17186.1 - 0.073 12.6 0.2 4.8 6.8 0.0 3.3 4 0 0 4 4 4 0 Antitoxin Phd_YefM, type II toxin-antitoxin system DZR PF12773.2 AIC17189.1 - 0.0029 17.3 1.3 0.0063 16.3 0.9 1.5 1 0 0 1 1 1 1 Double zinc ribbon Phage_int_SAM_4 PF13495.1 AIC17189.1 - 0.011 16.0 1.6 0.031 14.6 0.4 2.3 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain zf-ribbon_3 PF13248.1 AIC17189.1 - 0.013 14.6 1.8 0.025 13.7 1.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain Phage_int_SAM_1 PF02899.12 AIC17189.1 - 0.035 14.2 0.4 0.12 12.5 0.3 1.9 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain UPF0547 PF10571.4 AIC17189.1 - 0.053 13.2 1.4 0.12 12.1 0.9 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Radical_SAM PF04055.16 AIC17190.1 - 3.2e-11 43.6 0.4 1.3e-10 41.6 0.2 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_14 PF13394.1 AIC17190.1 - 2.5e-08 33.9 0.4 5.8e-08 32.7 0.2 1.6 2 0 0 2 2 2 1 4Fe-4S single cluster domain Fer4_12 PF13353.1 AIC17190.1 - 1.6e-07 31.5 0.1 3.1e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain EndIII_4Fe-2S PF10576.4 AIC17190.1 - 0.065 13.4 0.1 0.17 12.1 0.1 1.7 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Cyclase PF04199.8 AIC17191.1 - 2.9e-32 111.6 0.1 3.6e-32 111.4 0.1 1.1 1 0 0 1 1 1 1 Putative cyclase AsnC_trans_reg PF01037.16 AIC17192.1 - 4.5e-13 48.7 0.2 4.9e-13 48.5 0.1 1.0 1 0 0 1 1 1 1 AsnC family Aminotran_5 PF00266.14 AIC17193.1 - 3.9e-68 229.8 0.0 4.7e-68 229.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.16 AIC17193.1 - 0.0001 21.5 0.0 0.00018 20.7 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase AAA_24 PF13479.1 AIC17194.1 - 0.021 14.3 0.0 0.028 14.0 0.0 1.1 1 0 0 1 1 1 0 AAA domain Anoctamin PF04547.7 AIC17194.1 - 0.071 11.7 0.0 0.088 11.4 0.0 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel OST3_OST6 PF04756.8 AIC17195.1 - 0.00059 19.4 0.8 0.00086 18.9 0.6 1.3 1 1 0 1 1 1 1 OST3 / OST6 family DUF4118 PF13493.1 AIC17195.1 - 0.27 11.4 5.1 0.27 11.4 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4118) DUF1761 PF08570.5 AIC17195.1 - 7 6.6 10.0 2.7 8.0 0.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1761) APG17 PF04108.7 AIC17196.1 - 0.034 12.9 0.0 0.077 11.7 0.0 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 RRN7 PF11781.3 AIC17196.1 - 0.039 13.4 4.0 0.11 12.0 2.7 1.8 1 1 0 1 1 1 0 RNA polymerase I-specific transcription initiation factor Rrn7 DUF4256 PF14066.1 AIC17196.1 - 0.31 10.5 1.7 1.9 7.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4256) Cpn60_TCP1 PF00118.19 AIC17197.1 - 9.7e-170 565.3 15.9 1.1e-169 565.1 11.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ustilago_mating PF05722.7 AIC17197.1 - 0.064 12.5 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 Ustilago B locus mating-type protein Rhomboid PF01694.17 AIC17198.1 - 7.4e-32 110.3 18.2 1.2e-31 109.6 12.6 1.3 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.5 AIC17198.1 - 0.091 13.1 0.2 0.091 13.1 0.2 2.6 2 1 1 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) zf-C2H2_4 PF13894.1 AIC17199.1 - 7.1e-06 26.0 0.5 9.2e-06 25.6 0.3 1.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.21 AIC17199.1 - 3.9e-05 23.7 3.1 5e-05 23.3 2.2 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-BED PF02892.10 AIC17199.1 - 0.00019 21.1 0.5 0.00024 20.7 0.3 1.2 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_2 PF12756.2 AIC17199.1 - 0.0004 20.4 0.2 0.00042 20.3 0.2 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.1 AIC17199.1 - 0.0042 17.2 1.4 0.0067 16.5 0.9 1.4 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2_jaz PF12171.3 AIC17199.1 - 0.0044 17.1 3.3 0.0065 16.5 2.3 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.10 AIC17199.1 - 0.0081 15.5 0.2 0.011 15.2 0.1 1.2 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-Di19 PF05605.7 AIC17199.1 - 0.0091 16.1 0.1 0.011 15.7 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.1 AIC17199.1 - 0.0095 16.1 2.1 2 8.8 0.2 2.2 2 0 0 2 2 2 2 Zinc-finger double domain HNH PF01844.18 AIC17199.1 - 0.014 15.2 0.2 0.019 14.8 0.1 1.2 1 0 0 1 1 1 0 HNH endonuclease DUF629 PF04780.7 AIC17199.1 - 0.026 13.0 0.1 0.027 13.0 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) DUF4187 PF13821.1 AIC17199.1 - 0.076 12.6 0.7 0.11 12.0 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) zf-CHCC PF10276.4 AIC17199.1 - 0.09 12.6 0.4 0.13 12.1 0.3 1.3 1 0 0 1 1 1 0 Zinc-finger domain Rad50_zn_hook PF04423.9 AIC17199.1 - 0.13 11.7 1.2 0.16 11.4 0.8 1.1 1 0 0 1 1 1 0 Rad50 zinc hook motif AsnC_trans_reg PF01037.16 AIC17200.1 - 6.6e-13 48.1 0.2 7.1e-13 48.0 0.2 1.0 1 0 0 1 1 1 1 AsnC family GYD PF08734.6 AIC17200.1 - 0.022 14.4 0.1 0.022 14.4 0.1 1.2 1 0 0 1 1 1 0 GYD domain HTH_20 PF12840.2 AIC17201.1 - 9.1e-07 28.5 0.4 1.5e-06 27.9 0.3 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.2 AIC17201.1 - 0.00095 18.7 0.3 0.016 14.8 0.1 2.2 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.1 AIC17201.1 - 0.021 15.1 0.1 0.054 13.8 0.1 1.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain HTH_45 PF14947.1 AIC17201.1 - 0.045 13.5 0.0 0.082 12.7 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Ribosomal_L11_N PF03946.9 AIC17202.1 - 2.3e-21 74.9 1.1 4.7e-21 74.0 0.7 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.14 AIC17202.1 - 1.3e-19 70.0 3.9 2.2e-19 69.3 2.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Peptidase_S8 PF00082.17 AIC17203.1 - 2.7e-28 98.9 0.2 1.1e-27 96.9 0.0 2.2 2 1 0 2 2 2 1 Subtilase family Big_3_4 PF13754.1 AIC17203.1 - 7.3e-18 64.6 14.3 2.7e-06 27.5 0.0 5.4 5 0 0 5 5 5 3 Bacterial Ig-like domain (group 3) Big_3_3 PF13750.1 AIC17203.1 - 6.2e-10 38.7 0.1 0.0028 17.1 0.0 3.7 3 0 0 3 3 3 3 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.8 AIC17203.1 - 0.00047 19.8 0.0 0.23 11.2 0.0 3.2 3 0 0 3 3 3 1 Y_Y_Y domain EF-hand_5 PF13202.1 AIC17203.1 - 0.11 11.8 0.0 0.44 9.9 0.0 2.1 1 0 0 1 1 1 0 EF hand DUF4625 PF15418.1 AIC17203.1 - 0.16 12.1 0.0 14 5.7 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) EF-hand_1 PF00036.27 AIC17203.1 - 0.27 10.6 0.0 0.96 8.9 0.0 2.0 1 0 0 1 1 1 0 EF hand Thioredoxin PF00085.15 AIC17204.1 - 5e-29 100.0 0.0 5.6e-29 99.8 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.1 AIC17204.1 - 4.2e-09 36.3 0.1 9.6e-07 28.8 0.0 2.2 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.1 AIC17204.1 - 2e-08 34.4 0.1 1.6e-07 31.5 0.0 1.9 1 1 0 1 1 1 1 Thioredoxin-like domain Redoxin PF08534.5 AIC17204.1 - 2e-07 30.6 0.1 4.6e-07 29.4 0.1 1.7 1 1 0 1 1 1 1 Redoxin Thioredoxin_7 PF13899.1 AIC17204.1 - 1.2e-05 25.2 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like AhpC-TSA PF00578.16 AIC17204.1 - 2e-05 24.2 0.3 0.00014 21.5 0.2 1.8 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_9 PF14595.1 AIC17204.1 - 0.00022 20.7 0.0 0.00025 20.6 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.1 AIC17204.1 - 0.0028 17.4 0.0 0.0037 17.0 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain T4_deiodinase PF00837.12 AIC17204.1 - 0.012 14.5 0.0 0.014 14.4 0.0 1.1 1 0 0 1 1 1 0 Iodothyronine deiodinase GTP_EFTU PF00009.22 AIC17205.1 - 6.1e-30 104.0 0.0 2.7e-29 101.9 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.3 AIC17205.1 - 1.6e-21 76.2 1.3 1.6e-21 76.2 0.9 2.4 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D4 PF14578.1 AIC17205.1 - 8.2e-14 51.0 1.8 1.3e-13 50.3 0.2 2.2 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.20 AIC17205.1 - 5.8e-09 35.9 1.4 2e-06 27.7 0.0 3.5 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.18 AIC17205.1 - 7.3e-07 29.1 0.0 1.8e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Miro PF08477.8 AIC17205.1 - 2.4e-06 28.0 0.1 8.7e-06 26.2 0.0 2.0 2 0 0 2 2 2 1 Miro-like protein ATP_bind_1 PF03029.12 AIC17205.1 - 0.0015 18.0 0.0 0.027 14.0 0.0 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein Dynamin_N PF00350.18 AIC17205.1 - 0.0038 17.0 0.1 0.041 13.6 0.0 2.4 2 0 0 2 2 2 1 Dynamin family Ras PF00071.17 AIC17205.1 - 0.0044 16.4 0.0 0.055 12.8 0.0 2.4 1 1 0 1 1 1 1 Ras family AAA_16 PF13191.1 AIC17205.1 - 0.017 15.0 0.1 0.053 13.5 0.0 1.9 2 0 0 2 2 1 0 AAA ATPase domain SRPRB PF09439.5 AIC17205.1 - 0.023 13.9 0.2 0.51 9.5 0.0 3.0 4 0 0 4 4 4 0 Signal recognition particle receptor beta subunit MobB PF03205.9 AIC17205.1 - 0.05 13.2 0.1 0.14 11.8 0.0 1.8 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B DUF258 PF03193.11 AIC17205.1 - 0.059 12.5 0.1 1.7 7.8 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function, DUF258 PduV-EutP PF10662.4 AIC17205.1 - 0.06 12.8 0.2 0.45 10.0 0.0 2.5 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation FeoB_N PF02421.13 AIC17205.1 - 0.15 11.2 0.9 2.3 7.4 0.1 3.1 3 1 0 3 3 3 0 Ferrous iron transport protein B NDK PF00334.14 AIC17206.1 - 3e-48 163.0 0.0 3.3e-48 162.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Ribosomal_L24e PF01246.15 AIC17207.1 - 6.2e-19 67.6 0.9 6.5e-19 67.5 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L24e DUF581 PF04570.9 AIC17207.1 - 0.0016 17.7 0.7 0.0024 17.1 0.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF581) zf-FCS PF06467.9 AIC17207.1 - 0.017 14.7 2.1 0.024 14.2 1.5 1.3 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif DUF2175 PF09943.4 AIC17207.1 - 0.018 15.0 0.1 0.021 14.8 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) DUF2116 PF09889.4 AIC17207.1 - 0.31 10.8 2.5 1 9.1 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) A2L_zn_ribbon PF08792.5 AIC17207.1 - 1.7 8.2 4.3 22 4.6 0.1 2.5 2 1 1 3 3 3 0 A2L zinc ribbon domain Ribosomal_S28e PF01200.13 AIC17208.1 - 8.8e-31 105.4 6.5 9.3e-31 105.3 4.5 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Ribosomal_L7Ae PF01248.21 AIC17209.1 - 9.2e-27 92.4 0.2 1.1e-26 92.1 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Phage_CP76 PF06892.6 AIC17209.1 - 0.03 13.6 0.2 0.14 11.4 0.0 1.8 2 0 0 2 2 2 0 Phage regulatory protein CII (CP76) DUF4320 PF14208.1 AIC17209.1 - 0.049 13.5 0.1 0.099 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) PELOTA_1 PF15608.1 AIC17209.1 - 0.1 12.3 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 PELOTA RNA binding domain RNase_P_pop3 PF08228.6 AIC17209.1 - 0.12 12.1 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 PGM_PMM_I PF02878.11 AIC17210.1 - 3.7e-40 136.6 0.0 1.3e-39 134.7 0.0 2.0 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.11 AIC17210.1 - 3.3e-24 85.1 0.2 9.4e-24 83.7 0.1 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.11 AIC17210.1 - 4.2e-23 81.5 0.0 7.8e-23 80.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.15 AIC17210.1 - 7.9e-10 38.6 0.0 2.2e-09 37.2 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain NRPS PF08415.5 AIC17210.1 - 0.18 11.5 0.4 0.76 9.5 0.1 2.3 2 0 0 2 2 2 0 Nonribosomal peptide synthase Rota_NSP4 PF01452.11 AIC17211.1 - 0.0082 15.4 0.3 0.021 14.2 0.2 1.6 1 0 0 1 1 1 1 Rotavirus non structural protein DDE_Tnp_IS240 PF13610.1 AIC17212.1 - 3.2e-18 66.0 0.4 7.6e-18 64.8 0.3 1.7 1 0 0 1 1 1 1 DDE domain rve PF00665.21 AIC17212.1 - 1.4e-10 41.3 0.2 3e-10 40.2 0.2 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.1 AIC17212.1 - 2.9e-05 23.4 0.0 9.4e-05 21.8 0.0 1.9 1 0 0 1 1 1 1 Integrase core domain Transposase_mut PF00872.13 AIC17212.1 - 0.00011 20.9 0.1 0.14 10.6 0.1 2.2 2 0 0 2 2 2 2 Transposase, Mutator family SWIM PF04434.12 AIC17212.1 - 0.0018 17.6 0.3 0.0039 16.6 0.2 1.6 1 0 0 1 1 1 1 SWIM zinc finger Zn_Tnp_IS1595 PF12760.2 AIC17212.1 - 0.0035 17.1 1.5 0.0067 16.2 1.1 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.5 AIC17212.1 - 0.018 14.9 2.6 2.5 8.1 0.1 3.2 3 0 0 3 3 3 0 Zinc ribbon domain Terminase_5 PF06056.7 AIC17212.1 - 0.05 13.1 0.2 0.21 11.1 0.1 2.1 1 1 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) HTH_28 PF13518.1 AIC17212.1 - 0.065 13.2 0.3 0.22 11.5 0.2 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_32 PF13565.1 AIC17212.1 - 0.072 13.9 0.0 0.22 12.3 0.0 1.9 2 0 0 2 2 1 0 Homeodomain-like domain HTH_23 PF13384.1 AIC17212.1 - 0.075 12.7 0.1 2.8 7.7 0.1 2.7 2 0 0 2 2 2 0 Homeodomain-like domain OrfB_Zn_ribbon PF07282.6 AIC17212.1 - 0.081 12.5 4.9 0.71 9.5 1.0 3.0 3 0 0 3 3 3 0 Putative transposase DNA-binding domain Zn_Tnp_IS1 PF03811.8 AIC17212.1 - 0.1 12.1 1.8 0.25 10.8 1.3 1.6 1 0 0 1 1 1 0 InsA N-terminal domain zinc_ribbon_5 PF13719.1 AIC17212.1 - 0.68 9.5 6.0 0.39 10.3 2.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC17212.1 - 1.5 8.6 5.5 0.8 9.4 1.9 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-C2H2 PF00096.21 AIC17212.1 - 2.4 8.6 6.5 0.24 11.8 0.9 2.1 2 0 0 2 2 1 0 Zinc finger, C2H2 type Antitoxin-MazE PF04014.13 AIC17213.1 - 0.00029 20.4 1.4 0.00035 20.2 0.6 1.4 1 1 0 1 1 1 1 Antidote-toxin recognition MazE Nucleoporin2 PF04096.9 AIC17214.1 - 0.025 14.3 0.1 1.2 8.9 0.0 2.1 1 1 0 2 2 2 0 Nucleoporin autopeptidase PKI PF02827.11 AIC17215.1 - 0.017 15.2 0.4 0.023 14.7 0.3 1.2 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor Histone_HNS PF00816.16 AIC17215.1 - 0.058 13.9 2.1 0.069 13.6 1.4 1.1 1 0 0 1 1 1 0 H-NS histone family DUF1805 PF08827.6 AIC17215.1 - 0.1 12.4 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1805) Gar1 PF04410.9 AIC17215.1 - 0.1 12.0 2.2 0.12 11.8 1.5 1.0 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region L_lactis_ph-MCP PF06673.6 AIC17215.1 - 0.39 9.4 2.3 0.44 9.2 1.6 1.1 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein zinc_ribbon_2 PF13240.1 AIC17216.1 - 0.00011 21.5 0.0 0.0002 20.7 0.0 1.4 1 1 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.1 AIC17216.1 - 0.00046 19.2 0.9 0.23 10.7 0.1 2.1 2 0 0 2 2 2 2 zinc-ribbon domain Cript PF10235.4 AIC17216.1 - 0.00078 19.7 0.4 0.0011 19.2 0.3 1.2 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DiS_P_DiS PF06750.8 AIC17216.1 - 0.0031 17.2 0.1 0.41 10.4 0.0 2.0 2 0 0 2 2 2 1 Bacterial Peptidase A24 N-terminal domain DZR PF12773.2 AIC17216.1 - 0.0038 17.0 1.4 0.011 15.5 1.0 1.7 1 1 1 2 2 2 2 Double zinc ribbon HypA PF01155.14 AIC17216.1 - 0.017 14.8 0.2 0.018 14.6 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase expression/synthesis hypA family DUF1272 PF06906.6 AIC17216.1 - 0.03 14.1 0.9 3 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zinc_ribbon_5 PF13719.1 AIC17216.1 - 0.031 13.8 2.7 0.13 11.8 1.9 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zinc-ribbons_6 PF07191.7 AIC17216.1 - 0.04 13.7 0.8 0.094 12.5 0.6 1.5 1 1 0 1 1 1 0 zinc-ribbons PAAR_motif PF05488.8 AIC17216.1 - 0.056 13.4 0.1 0.073 13.0 0.1 1.1 1 0 0 1 1 1 0 PAAR motif zf-ISL3 PF14690.1 AIC17216.1 - 0.06 13.3 2.5 6.3 6.9 0.2 2.4 2 1 0 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 DNA_ligase_ZBD PF03119.11 AIC17216.1 - 0.068 12.8 0.1 0.068 12.8 0.0 2.2 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-TFIIB PF13453.1 AIC17216.1 - 0.081 12.1 0.4 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger Zn-ribbon_8 PF09723.5 AIC17216.1 - 0.094 12.6 0.4 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 Zinc ribbon domain zinc_ribbon_4 PF13717.1 AIC17216.1 - 0.095 12.4 3.0 0.32 10.7 2.1 1.9 1 1 0 1 1 1 0 zinc-ribbon domain Prok-RING_1 PF14446.1 AIC17216.1 - 0.11 12.2 1.4 4.6 7.0 0.0 2.1 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 GFA PF04828.9 AIC17216.1 - 0.12 12.3 1.2 0.86 9.5 0.0 2.0 1 1 1 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme DNA_RNApol_7kD PF03604.8 AIC17216.1 - 0.13 11.7 1.6 6.2 6.3 1.1 2.3 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Auto_anti-p27 PF06677.7 AIC17216.1 - 0.14 11.9 1.9 0.8 9.5 0.1 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF4451 PF14616.1 AIC17216.1 - 0.24 11.1 1.7 4.8 6.9 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4451) zf-C4_Topoisom PF01396.14 AIC17216.1 - 0.64 9.5 6.7 1.3 8.5 2.3 2.7 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Ferritin PF00210.19 AIC17217.1 - 4.3e-18 65.4 3.3 5.3e-18 65.1 2.3 1.1 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.12 AIC17217.1 - 8.8e-09 35.8 3.5 1e-08 35.5 2.4 1.1 1 0 0 1 1 1 1 Rubrerythrin Ferritin_2 PF13668.1 AIC17217.1 - 0.0002 21.3 0.6 0.00023 21.1 0.4 1.1 1 0 0 1 1 1 1 Ferritin-like domain Seryl_tRNA_N PF02403.17 AIC17218.1 - 0.73 9.8 3.3 0.27 11.2 0.8 1.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DNA_pol3_delta2 PF13177.1 AIC17219.1 - 0.0065 16.1 0.0 0.0074 15.9 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DUF4539 PF15072.1 AIC17219.1 - 0.11 12.1 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4539) SNO PF01174.14 AIC17220.1 - 1e-51 175.2 0.3 1.2e-51 175.0 0.2 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.9 AIC17220.1 - 1.2e-14 54.2 0.0 2e-14 53.5 0.0 1.4 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.23 AIC17220.1 - 1.6e-10 40.7 0.0 3.9e-10 39.5 0.0 1.5 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.8 AIC17220.1 - 1.3e-07 31.3 0.0 1.4e-06 27.9 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 DUF4066 PF13278.1 AIC17220.1 - 0.0035 16.6 0.0 0.0054 16.0 0.0 1.2 1 0 0 1 1 1 1 Putative amidotransferase Peptidase_S51 PF03575.12 AIC17220.1 - 0.0051 16.5 0.0 0.0076 15.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S51 DJ-1_PfpI PF01965.19 AIC17220.1 - 0.01 15.2 0.0 0.016 14.6 0.0 1.4 1 0 0 1 1 1 0 DJ-1/PfpI family SOR_SNZ PF01680.12 AIC17221.1 - 1.3e-92 309.0 5.5 1.9e-92 308.6 3.8 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.9 AIC17221.1 - 3.9e-08 32.6 6.0 1.3e-06 27.7 0.1 3.0 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.16 AIC17221.1 - 4.7e-06 26.0 2.3 0.12 11.6 0.0 3.2 2 1 1 3 3 3 3 Histidine biosynthesis protein Dus PF01207.12 AIC17221.1 - 7.2e-06 25.0 0.6 0.034 12.9 0.2 2.3 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) IGPS PF00218.16 AIC17221.1 - 0.0003 19.9 0.0 0.009 15.0 0.0 2.4 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase NMO PF03060.10 AIC17221.1 - 0.00071 18.8 6.2 0.12 11.4 0.1 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase NanE PF04131.9 AIC17221.1 - 0.0086 15.0 3.6 0.19 10.6 0.0 2.8 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase DUF2046 PF09755.4 AIC17221.1 - 0.044 12.6 0.1 0.069 12.0 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) PA PF02225.17 AIC17221.1 - 0.16 11.6 0.8 1.6 8.4 0.0 2.5 2 1 0 2 2 2 0 PA domain DUF1774 PF08611.5 AIC17222.1 - 0.12 12.4 0.1 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1774) Aconitase PF00330.15 AIC17223.1 - 9.6e-154 512.2 0.0 8.5e-153 509.1 0.0 1.9 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.14 AIC17223.1 - 1.2e-37 128.9 0.0 2.6e-37 127.8 0.0 1.6 1 0 0 1 1 1 1 Aconitase C-terminal domain DUF521 PF04412.8 AIC17223.1 - 0.074 11.5 0.0 0.13 10.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF521) Reovirus_L2 PF06016.6 AIC17225.1 - 0.063 10.2 0.1 0.063 10.2 0.0 1.0 1 0 0 1 1 1 0 Reovirus core-spike protein lambda-2 (L2) POR_N PF01855.14 AIC17226.1 - 1.3e-64 217.8 0.0 1.8e-64 217.3 0.0 1.2 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.13 AIC17226.1 - 3e-36 124.9 0.2 7.5e-36 123.6 0.1 1.6 1 0 0 1 1 1 1 Pyruvate ferredoxin/flavodoxin oxidoreductase Transketolase_C PF02780.15 AIC17226.1 - 1.6e-08 34.4 0.1 5.9e-08 32.6 0.0 1.9 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_N PF02776.13 AIC17226.1 - 0.00075 19.0 0.1 0.0016 17.9 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.16 AIC17227.1 - 3.4e-30 104.6 0.1 5.9e-30 103.8 0.1 1.4 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFO_beta_C PF12367.3 AIC17227.1 - 2.1e-09 37.1 0.6 1.1e-05 25.2 0.0 2.8 2 1 0 2 2 2 2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal Cas_csx3 PF09620.5 AIC17227.1 - 0.077 12.8 0.0 0.17 11.6 0.0 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_csx3) ChaB PF06150.7 AIC17228.1 - 3e-19 68.5 3.0 3.9e-19 68.1 2.1 1.1 1 0 0 1 1 1 1 ChaB PcfJ PF14284.1 AIC17228.1 - 0.11 12.0 1.5 0.12 11.8 1.0 1.1 1 0 0 1 1 1 0 PcfJ-like protein BRF1 PF07741.8 AIC17228.1 - 3 8.1 10.0 0.45 10.7 4.4 1.5 1 1 1 2 2 2 0 Brf1-like TBP-binding domain DUF4145 PF13643.1 AIC17229.1 - 2.5e-07 30.4 0.1 1.3e-06 28.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4145) HEPN PF05168.9 AIC17229.1 - 0.0094 15.8 0.3 0.043 13.7 0.0 2.0 1 1 1 2 2 2 1 HEPN domain Abi_2 PF07751.6 AIC17229.1 - 0.015 15.5 0.1 0.019 15.1 0.1 1.4 1 1 0 1 1 1 0 Abi-like protein DUF86 PF01934.12 AIC17229.1 - 0.016 14.8 0.1 0.035 13.7 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF86 SPOUT_MTase PF02590.12 AIC17229.1 - 0.096 12.4 0.6 1.3 8.7 0.0 2.5 1 1 0 2 2 2 0 Predicted SPOUT methyltransferase YlbE PF14003.1 AIC17229.1 - 0.57 10.2 4.2 0.98 9.5 0.1 2.8 2 1 1 3 3 3 0 YlbE-like protein DUF2688 PF10892.3 AIC17230.1 - 0.099 12.3 0.2 0.12 12.0 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2688) 2TM PF13239.1 AIC17231.1 - 0.0029 17.6 1.2 0.0041 17.1 0.8 1.2 1 0 0 1 1 1 1 2TM domain MscS_TM PF12794.2 AIC17231.1 - 0.025 13.1 0.2 0.025 13.1 0.1 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 AsnC_trans_reg PF01037.16 AIC17232.1 - 1.1e-14 53.9 0.2 1.2e-14 53.7 0.2 1.0 1 0 0 1 1 1 1 AsnC family ACT_4 PF13291.1 AIC17232.1 - 0.0058 16.9 0.4 0.83 10.0 0.0 2.1 2 0 0 2 2 2 2 ACT domain ACT_5 PF13710.1 AIC17232.1 - 0.028 14.2 0.0 3.5 7.4 0.0 2.2 2 0 0 2 2 2 0 ACT domain RRN7 PF11781.3 AIC17235.1 - 0.029 13.8 0.1 1.3 8.5 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase I-specific transcription initiation factor Rrn7 Rad50_zn_hook PF04423.9 AIC17235.1 - 0.047 13.1 0.1 0.19 11.2 0.0 1.9 2 0 0 2 2 2 0 Rad50 zinc hook motif DUF4428 PF14471.1 AIC17235.1 - 0.068 12.9 2.1 0.33 10.7 1.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) ADK_lid PF05191.9 AIC17235.1 - 0.078 12.6 0.3 0.28 10.8 0.0 2.0 2 0 0 2 2 2 0 Adenylate kinase, active site lid zf-HIT PF04438.11 AIC17235.1 - 0.24 11.0 2.5 0.34 10.5 0.1 2.0 2 0 0 2 2 2 0 HIT zinc finger amfpi-1 PF12190.3 AIC17235.1 - 0.34 11.4 2.2 0.94 10.0 1.5 1.8 1 1 1 2 2 2 0 Fungal protease inhibitor Copper-bind PF00127.15 AIC17236.1 - 0.0006 19.9 0.0 0.00088 19.4 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.1 AIC17236.1 - 0.0017 18.2 0.0 0.0023 17.8 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain AsnC_trans_reg PF01037.16 AIC17237.1 - 2.2e-11 43.2 0.1 2.4e-11 43.1 0.1 1.0 1 0 0 1 1 1 1 AsnC family ACT_4 PF13291.1 AIC17237.1 - 0.01 16.1 0.1 0.014 15.7 0.1 1.2 1 0 0 1 1 1 0 ACT domain ABC_tran PF00005.22 AIC17239.1 - 1.1e-21 77.6 0.0 2e-21 76.7 0.0 1.5 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.1 AIC17239.1 - 8.7e-13 48.8 0.1 1.1e-11 45.2 0.0 2.1 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.14 AIC17239.1 - 6e-11 42.0 0.4 1.2e-09 37.7 0.3 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_29 PF13555.1 AIC17239.1 - 9.6e-06 25.0 0.1 1.9e-05 24.1 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.1 AIC17239.1 - 1.3e-05 23.9 0.0 0.031 12.7 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_23 PF13476.1 AIC17239.1 - 2.3e-05 24.8 0.2 5.2e-05 23.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain DUF258 PF03193.11 AIC17239.1 - 0.0001 21.5 0.1 0.00034 19.8 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function, DUF258 AAA_17 PF13207.1 AIC17239.1 - 0.0001 23.0 0.1 0.00022 22.0 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_25 PF13481.1 AIC17239.1 - 0.00018 20.9 0.1 0.0089 15.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.1 AIC17239.1 - 0.00075 19.3 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain MutS_V PF00488.16 AIC17239.1 - 0.0015 17.9 0.1 1.2 8.4 0.0 2.1 2 0 0 2 2 2 2 MutS domain V AAA_16 PF13191.1 AIC17239.1 - 0.0036 17.2 0.0 0.012 15.6 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.1 AIC17239.1 - 0.0042 17.3 1.7 0.17 12.1 0.1 2.9 2 2 1 3 3 2 1 AAA domain ANF_receptor PF01094.23 AIC17239.1 - 0.0047 15.7 0.0 0.16 10.7 0.0 2.2 2 0 0 2 2 2 1 Receptor family ligand binding region AAA_10 PF12846.2 AIC17239.1 - 0.011 15.1 0.2 0.029 13.7 0.0 1.7 2 1 0 2 2 2 0 AAA-like domain AAA_15 PF13175.1 AIC17239.1 - 0.013 14.6 0.0 0.6 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.1 AIC17239.1 - 0.015 15.1 0.1 0.35 10.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain ABC_ATPase PF09818.4 AIC17239.1 - 0.022 13.3 0.1 0.037 12.6 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA PF00004.24 AIC17239.1 - 0.023 14.8 0.1 0.12 12.5 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.18 AIC17239.1 - 0.024 14.6 0.5 0.063 13.2 0.4 2.1 1 1 0 1 1 1 0 50S ribosome-binding GTPase Cep57_MT_bd PF06657.8 AIC17239.1 - 0.026 14.4 0.1 5.4 7.0 0.0 2.5 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 AAA_19 PF13245.1 AIC17239.1 - 0.027 14.2 0.5 3.7 7.3 0.0 2.3 2 0 0 2 2 2 0 Part of AAA domain AAA_22 PF13401.1 AIC17239.1 - 0.029 14.5 0.1 0.38 10.8 0.0 2.4 2 1 0 2 2 2 0 AAA domain T2SE PF00437.15 AIC17239.1 - 0.046 12.6 0.0 0.074 11.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Arch_ATPase PF01637.13 AIC17239.1 - 0.051 13.2 0.0 0.12 12.0 0.0 1.6 1 1 0 1 1 1 0 Archaeal ATPase Dynamin_N PF00350.18 AIC17239.1 - 0.057 13.2 0.0 0.25 11.1 0.0 1.9 2 0 0 2 2 2 0 Dynamin family NB-ARC PF00931.17 AIC17239.1 - 0.06 12.1 0.0 0.11 11.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RNA_helicase PF00910.17 AIC17239.1 - 0.066 13.3 0.0 0.5 10.5 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.1 AIC17239.1 - 0.066 13.1 0.0 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.7 AIC17239.1 - 0.073 12.7 0.0 0.21 11.2 0.0 1.7 2 1 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.12 AIC17239.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATP_bind_1 PF03029.12 AIC17239.1 - 0.12 11.8 0.2 0.73 9.3 0.0 2.3 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein AIG1 PF04548.11 AIC17239.1 - 0.15 11.1 0.2 0.95 8.5 0.0 2.0 2 0 0 2 2 2 0 AIG1 family Alba PF01918.16 AIC17239.1 - 0.24 11.0 1.3 21 4.8 0.6 3.1 2 1 0 2 2 2 0 Alba Chlor_dismutase PF06778.7 AIC17240.1 - 5e-55 186.2 0.7 6.4e-55 185.8 0.5 1.1 1 0 0 1 1 1 1 Chlorite dismutase DUF1802 PF08819.6 AIC17241.1 - 5.6e-53 179.1 0.1 6.3e-53 178.9 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) Aldo_ket_red PF00248.16 AIC17242.1 - 1.9e-56 190.9 0.1 2.2e-56 190.7 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family HTH_AsnC-type PF13404.1 AIC17243.1 - 8.1e-10 38.0 0.0 0.00077 18.9 0.0 2.6 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.16 AIC17243.1 - 4.6e-05 23.0 0.0 0.24 11.1 0.0 3.1 2 1 0 2 2 2 2 AsnC family DUF2250 PF10007.4 AIC17243.1 - 0.014 15.2 0.0 1.5 8.8 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) Sigma70_r4 PF04545.11 AIC17243.1 - 0.037 13.3 0.0 0.21 10.9 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_24 PF13412.1 AIC17243.1 - 0.053 12.9 0.7 13 5.2 0.2 3.0 2 1 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF3505 PF12013.3 AIC17244.1 - 0.024 14.8 0.2 0.031 14.5 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3505) DUF3654 PF12376.3 AIC17244.1 - 0.052 13.3 0.4 0.054 13.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3654) ADK PF00406.17 AIC17244.1 - 0.12 12.2 0.0 0.12 12.2 0.0 1.0 1 0 0 1 1 1 0 Adenylate kinase HTH_45 PF14947.1 AIC17245.1 - 1.9e-13 50.0 0.0 2.2e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix PadR PF03551.9 AIC17245.1 - 0.001 18.8 0.5 0.0013 18.4 0.3 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family DUF4364 PF14277.1 AIC17245.1 - 0.002 17.7 0.0 0.0026 17.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_34 PF13601.1 AIC17245.1 - 0.0021 18.0 0.0 0.0033 17.4 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF1495 PF07381.6 AIC17245.1 - 0.0081 15.8 0.1 0.01 15.5 0.0 1.3 1 1 0 1 1 1 1 Winged helix DNA-binding domain (DUF1495) Mrr_N PF14338.1 AIC17245.1 - 0.0083 16.1 0.0 0.017 15.1 0.0 1.6 1 1 0 1 1 1 1 Mrr N-terminal domain ATP-synt_Eps PF04627.8 AIC17245.1 - 0.057 12.9 0.1 0.099 12.2 0.0 1.5 2 0 0 2 2 2 0 Mitochondrial ATP synthase epsilon chain TrmB PF01978.14 AIC17245.1 - 0.069 12.8 0.0 0.095 12.4 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.17 AIC17245.1 - 0.081 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.15 AIC17245.1 - 0.095 12.8 0.1 0.14 12.2 0.1 1.2 1 0 0 1 1 1 0 Transcriptional regulator PAX PF00292.13 AIC17245.1 - 0.15 11.8 0.0 0.16 11.7 0.0 1.1 1 0 0 1 1 1 0 'Paired box' domain Kdo_hydroxy PF11004.3 AIC17246.1 - 0.033 13.1 0.1 0.042 12.8 0.1 1.3 1 0 0 1 1 1 0 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase CxxCxxCC PF03692.10 AIC17247.1 - 6.9e-05 23.2 0.0 0.00011 22.5 0.0 1.5 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain Baculo_IE-1 PF05290.6 AIC17247.1 - 0.044 13.5 0.4 0.07 12.8 0.3 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) DUF504 PF04457.7 AIC17248.1 - 0.044 13.9 0.0 0.076 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF504) Aconitase_C PF00694.14 AIC17249.1 - 6.8e-22 77.9 0.0 2.7e-20 72.8 0.0 2.2 1 1 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.8 AIC17249.1 - 0.011 15.1 0.1 0.094 12.1 0.0 1.9 1 1 1 2 2 2 0 Aconitate hydratase 2 N-terminus Aconitase PF00330.15 AIC17250.1 - 3.6e-81 273.0 5.8 1.1e-54 185.6 1.0 2.2 1 1 1 2 2 2 2 Aconitase family (aconitate hydratase) F420_ligase PF01996.11 AIC17251.1 - 4e-57 192.9 0.0 5e-57 192.6 0.0 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase TMF_DNA_bd PF12329.3 AIC17252.1 - 0.011 15.5 0.5 0.024 14.4 0.3 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF4250 PF14056.1 AIC17252.1 - 0.1 12.3 0.2 1.2 8.9 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) DUF2854 PF11016.3 AIC17254.1 - 0.022 14.2 0.2 0.038 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) HTH_45 PF14947.1 AIC17255.1 - 1.2e-21 76.2 1.3 1.6e-21 75.8 0.9 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.1 AIC17255.1 - 9.1e-05 22.1 0.3 0.00014 21.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) BCL9 PF11502.3 AIC17255.1 - 0.059 12.8 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 B-cell lymphoma 9 protein Aminotran_3 PF00202.16 AIC17255.1 - 0.06 12.1 0.0 0.088 11.6 0.0 1.4 1 1 0 1 1 1 0 Aminotransferase class-III Band_7 PF01145.20 AIC17258.1 - 2.4e-31 109.0 0.5 2.4e-31 109.0 0.3 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.1 AIC17258.1 - 8.4e-05 22.1 0.1 0.00029 20.4 0.0 1.9 3 0 0 3 3 3 1 SPFH domain-Band 7 family SKI PF01202.17 AIC17258.1 - 0.026 14.4 0.2 0.098 12.5 0.0 1.9 1 1 1 2 2 2 0 Shikimate kinase Phage_P2_GpE PF06528.7 AIC17258.1 - 1.1 8.7 7.2 0.66 9.4 0.6 2.7 2 0 0 2 2 2 0 Phage P2 GpE NfeD PF01957.13 AIC17259.1 - 2.6e-21 76.2 3.2 2.6e-21 76.2 2.2 2.3 2 0 0 2 2 2 1 NfeD-like C-terminal, partner-binding CLP_protease PF00574.18 AIC17259.1 - 6.9e-05 22.5 0.2 0.00021 21.0 0.1 1.9 2 0 0 2 2 2 1 Clp protease DUF3918 PF13056.1 AIC17259.1 - 0.21 10.9 0.5 0.51 9.7 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) FYVE_2 PF02318.11 AIC17260.1 - 0.55 10.1 9.9 0.42 10.5 5.6 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger DUF2039 PF10217.4 AIC17260.1 - 0.66 10.0 10.5 0.51 10.3 0.8 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2039) PHF5 PF03660.9 AIC17260.1 - 4 7.5 12.4 0.081 12.9 2.9 2.1 1 1 1 2 2 2 0 PHF5-like protein His_Phos_1 PF00300.17 AIC17261.1 - 1.9e-13 50.8 0.0 1.7e-12 47.7 0.0 1.9 1 1 1 2 2 2 1 Histidine phosphatase superfamily (branch 1) CAP PF00188.21 AIC17262.1 - 1.4e-20 73.9 2.0 2.6e-20 73.1 1.4 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family DUF1376 PF07120.6 AIC17265.1 - 0.01 15.9 0.0 0.015 15.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1376) DnaJ_CXXCXGXG PF00684.14 AIC17266.1 - 0.11 12.6 17.7 0.69 10.0 6.5 2.9 1 1 1 2 2 2 0 DnaJ central domain Lar_restr_allev PF14354.1 AIC17266.1 - 1.3 9.3 11.4 7.1 7.0 7.9 1.9 1 1 0 1 1 1 0 Restriction alleviation protein Lar TNFR_c6 PF00020.13 AIC17266.1 - 2 8.5 9.3 7.1 6.7 0.7 2.2 2 0 0 2 2 2 0 TNFR/NGFR cysteine-rich region ArfGap PF01412.13 AIC17266.1 - 6.3 6.6 7.2 8.1 6.2 5.0 1.3 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf Copper-bind PF00127.15 AIC17267.1 - 3.1e-09 36.9 0.0 6.7e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Big_3_4 PF13754.1 AIC17267.1 - 2.7e-08 33.9 3.9 8.8e-07 29.1 0.1 3.9 5 0 0 5 5 5 1 Bacterial Ig-like domain (group 3) Cupredoxin_1 PF13473.1 AIC17267.1 - 1e-07 31.7 0.0 4.4e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 Cupredoxin-like domain HYR PF02494.11 AIC17267.1 - 0.0049 16.8 0.3 2.2 8.3 0.0 3.6 4 0 0 4 4 4 1 HYR domain PKD PF00801.15 AIC17267.1 - 0.0083 15.8 0.0 5.2 6.9 0.0 3.2 3 1 0 3 3 3 1 PKD domain Gmad2 PF10648.4 AIC17267.1 - 0.074 13.2 0.5 0.3 11.3 0.1 2.3 2 2 0 2 2 2 0 Immunoglobulin-like domain of bacterial spore germination Y_Y_Y PF07495.8 AIC17267.1 - 0.083 12.6 0.1 0.6 9.9 0.0 2.3 2 0 0 2 2 2 0 Y_Y_Y domain FlgD_ig PF13860.1 AIC17267.1 - 0.087 12.5 0.2 0.37 10.5 0.1 2.1 1 1 0 1 1 1 0 FlgD Ig-like domain Big_3_3 PF13750.1 AIC17267.1 - 0.095 12.1 0.0 0.5 9.7 0.0 2.0 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) DivIC PF04977.10 AIC17268.1 - 1 8.8 4.6 2.7 7.5 3.2 1.6 1 0 0 1 1 1 0 Septum formation initiator Baculo_ME53 PF06061.6 AIC17269.1 - 0.0029 16.6 1.0 0.0034 16.4 0.7 1.0 1 0 0 1 1 1 1 Baculoviridae ME53 HNH_3 PF13392.1 AIC17269.1 - 0.0031 16.8 0.4 0.0031 16.8 0.3 1.6 2 0 0 2 2 2 1 HNH endonuclease HNH PF01844.18 AIC17269.1 - 0.0048 16.7 0.3 0.0078 16.0 0.2 1.4 1 0 0 1 1 1 1 HNH endonuclease Terminase_GpA PF05876.7 AIC17269.1 - 0.015 13.7 0.1 0.016 13.6 0.1 1.0 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) TP2 PF01254.13 AIC17269.1 - 0.064 13.6 0.6 0.081 13.2 0.4 1.1 1 0 0 1 1 1 0 Nuclear transition protein 2 RasGAP PF00616.14 AIC17269.1 - 0.085 12.5 0.0 0.092 12.3 0.0 1.1 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase OS-D PF03392.8 AIC17269.1 - 0.1 12.5 1.0 0.43 10.5 0.2 1.8 1 1 1 2 2 2 0 Insect pheromone-binding family, A10/OS-D DZR PF12773.2 AIC17269.1 - 0.23 11.3 4.3 0.43 10.4 3.0 1.4 1 1 0 1 1 1 0 Double zinc ribbon Nudix_N_2 PF14803.1 AIC17269.1 - 0.33 10.6 3.1 13 5.5 0.1 2.3 2 0 0 2 2 2 0 Nudix N-terminal zinc_ribbon_5 PF13719.1 AIC17269.1 - 0.59 9.7 3.6 4.4 6.9 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_4 PF13717.1 AIC17269.1 - 0.64 9.7 4.0 4.4 7.0 0.5 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF3815 PF12821.2 AIC17270.1 - 0.11 12.4 0.1 0.16 11.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3815) UPF0086 PF01868.11 AIC17272.1 - 0.037 13.6 0.1 0.078 12.6 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function UPF0086 AsnC_trans_reg PF01037.16 AIC17273.1 - 3e-13 49.2 0.1 4.9e-13 48.5 0.0 1.3 1 0 0 1 1 1 1 AsnC family HTH_24 PF13412.1 AIC17273.1 - 7.8e-10 37.9 0.7 1.3e-09 37.3 0.5 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.1 AIC17273.1 - 5.5e-09 35.4 0.2 9.5e-09 34.6 0.1 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain B-block_TFIIIC PF04182.7 AIC17273.1 - 0.0016 18.2 0.1 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_20 PF12840.2 AIC17273.1 - 0.0018 18.0 0.1 0.0057 16.4 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_11 PF08279.7 AIC17273.1 - 0.0082 15.7 0.4 0.021 14.4 0.3 1.7 1 0 0 1 1 1 1 HTH domain MarR_2 PF12802.2 AIC17273.1 - 0.0088 15.7 0.0 0.014 15.0 0.0 1.3 1 0 0 1 1 1 1 MarR family TrmB PF01978.14 AIC17273.1 - 0.017 14.8 0.1 0.034 13.8 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_34 PF13601.1 AIC17273.1 - 0.019 14.9 0.1 0.04 13.9 0.1 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_psq PF05225.11 AIC17273.1 - 0.025 14.1 0.3 0.043 13.3 0.2 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain MarR PF01047.17 AIC17273.1 - 0.026 14.2 0.2 0.052 13.2 0.1 1.4 1 0 0 1 1 1 0 MarR family Rrf2 PF02082.15 AIC17273.1 - 0.049 13.7 0.1 0.098 12.7 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator Sulfolobus_pRN PF05584.6 AIC17273.1 - 0.05 13.5 0.7 0.27 11.2 0.1 2.1 2 1 0 2 2 2 0 Sulfolobus plasmid regulatory protein Ribosomal_S25 PF03297.10 AIC17273.1 - 0.05 13.6 1.2 0.076 13.0 0.3 1.7 2 0 0 2 2 2 0 S25 ribosomal protein HxlR PF01638.12 AIC17274.1 - 7e-07 28.8 0.1 8.1e-07 28.5 0.1 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_45 PF14947.1 AIC17274.1 - 0.00016 21.4 0.0 0.00025 20.7 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn-helix Replic_Relax PF13814.1 AIC17274.1 - 0.00076 19.3 0.3 0.0011 18.8 0.2 1.3 1 1 0 1 1 1 1 Replication-relaxation HTH_20 PF12840.2 AIC17274.1 - 0.0033 17.1 0.0 0.0069 16.1 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain PadR PF03551.9 AIC17274.1 - 0.0042 16.8 0.2 0.0063 16.2 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family DUF2513 PF10711.4 AIC17274.1 - 0.014 15.5 0.0 0.016 15.2 0.0 1.1 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) HTH_5 PF01022.15 AIC17274.1 - 0.044 13.4 0.0 2.7 7.7 0.0 2.5 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family HTH_34 PF13601.1 AIC17274.1 - 0.081 12.9 0.1 0.11 12.4 0.1 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain DUF3116 PF11313.3 AIC17274.1 - 0.11 12.1 0.6 0.19 11.3 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3116) MarR_2 PF12802.2 AIC17274.1 - 0.11 12.1 0.0 0.4 10.3 0.0 1.9 2 0 0 2 2 2 0 MarR family MEKHLA PF08670.6 AIC17274.1 - 0.12 11.9 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 MEKHLA domain HTH_27 PF13463.1 AIC17274.1 - 0.13 12.5 0.1 0.2 12.0 0.0 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain Thioredoxin PF00085.15 AIC17277.1 - 6.2e-31 106.1 0.1 7e-31 106.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.1 AIC17277.1 - 3e-11 43.5 0.1 1.1e-10 41.6 0.1 1.8 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.1 AIC17277.1 - 5.7e-09 35.9 0.0 4.6e-06 26.6 0.0 2.3 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.1 AIC17277.1 - 2.7e-07 30.3 0.0 3.6e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_9 PF14595.1 AIC17277.1 - 5.6e-07 29.1 0.0 6.3e-07 29.0 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.1 AIC17277.1 - 7.4e-07 29.1 0.0 1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.5 AIC17277.1 - 0.00052 19.5 0.1 0.0011 18.5 0.1 1.5 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.16 AIC17277.1 - 0.001 18.7 0.1 0.045 13.4 0.1 2.0 1 1 1 2 2 2 2 AhpC/TSA family HyaE PF07449.6 AIC17277.1 - 0.0041 17.0 0.0 0.006 16.4 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE DUF836 PF05768.9 AIC17277.1 - 0.029 14.6 0.0 0.036 14.3 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) Thioredoxin_6 PF13848.1 AIC17277.1 - 0.034 13.9 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain Thioredoxin_4 PF13462.1 AIC17277.1 - 0.043 13.8 0.1 0.21 11.5 0.0 1.8 1 1 1 2 2 2 0 Thioredoxin TrbC_Ftype PF09673.5 AIC17277.1 - 0.13 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein tRNA-synt_2c PF01411.14 AIC17279.1 - 2.5e-82 276.9 0.0 4.2e-82 276.2 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.9 AIC17279.1 - 8.1e-16 57.6 4.7 1.3e-15 57.0 1.0 2.7 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.14 AIC17279.1 - 0.00029 20.4 4.5 0.00073 19.1 3.1 1.7 1 0 0 1 1 1 1 DHHA1 domain YolD PF08863.5 AIC17279.1 - 0.076 12.8 0.4 0.56 10.1 0.1 2.6 2 1 0 2 2 2 0 YolD-like protein tRNA-synt_1 PF00133.17 AIC17280.1 - 1.8e-64 217.8 0.3 3.3e-63 213.6 0.2 2.6 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.6 AIC17280.1 - 1.9e-25 89.3 2.8 1.1e-11 44.1 0.1 3.6 3 1 1 4 4 4 3 tRNA synthetases class I (M) Anticodon_1 PF08264.8 AIC17280.1 - 3.3e-21 75.6 0.1 7.7e-21 74.4 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.14 AIC17280.1 - 6.1e-13 48.5 0.1 4e-08 32.7 0.0 2.5 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.1 AIC17280.1 - 9.7e-13 47.8 0.0 2.6e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 Leucyl-tRNA synthetase, Domain 2 Response_reg PF00072.19 AIC17281.1 - 3.1e-22 78.6 0.0 4.4e-22 78.1 0.0 1.2 1 0 0 1 1 1 1 Response regulator receiver domain HTH_45 PF14947.1 AIC17281.1 - 3.1e-05 23.6 0.0 6.1e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_24 PF13412.1 AIC17281.1 - 0.00076 18.8 0.0 0.0014 17.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding SBDS_C PF09377.5 AIC17282.1 - 0.073 12.7 0.1 0.1 12.2 0.1 1.3 1 1 0 1 1 1 0 SBDS protein C-terminal domain HATPase_c PF02518.21 AIC17283.1 - 2.2e-23 82.0 0.0 6.9e-23 80.4 0.0 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.20 AIC17283.1 - 3.1e-13 49.4 0.1 1e-12 47.8 0.1 2.0 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.1 AIC17283.1 - 0.0061 16.3 0.0 0.016 14.9 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.1 AIC17283.1 - 0.036 13.7 0.0 0.088 12.4 0.0 1.6 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pyr_redox_2 PF07992.9 AIC17285.1 - 0.053 13.4 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Prefoldin PF02996.12 AIC17286.1 - 8.1e-19 67.4 3.7 1.4e-18 66.6 2.2 1.6 1 1 0 1 1 1 1 Prefoldin subunit DUF812 PF05667.6 AIC17286.1 - 0.0014 17.2 4.4 0.0016 17.0 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Prefoldin_2 PF01920.15 AIC17286.1 - 0.0062 16.2 2.3 0.0062 16.2 1.6 2.5 1 1 2 3 3 3 1 Prefoldin subunit CALCOCO1 PF07888.6 AIC17286.1 - 0.012 13.9 2.7 0.016 13.5 1.9 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Methyltransf_14 PF08484.6 AIC17286.1 - 0.11 11.9 2.2 0.19 11.2 0.1 1.9 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain Mod_r PF07200.8 AIC17286.1 - 0.13 12.2 4.1 0.22 11.4 0.7 2.1 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein YlqD PF11068.3 AIC17286.1 - 0.13 12.2 10.3 0.17 11.9 1.9 2.1 2 0 0 2 2 2 0 YlqD protein Ax_dynein_light PF10211.4 AIC17286.1 - 0.27 11.0 5.7 0.28 10.9 0.4 2.1 2 0 0 2 2 2 0 Axonemal dynein light chain CENP-F_leu_zip PF10473.4 AIC17286.1 - 0.33 10.7 5.7 0.91 9.3 0.1 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EMP24_GP25L PF01105.19 AIC17286.1 - 0.33 10.6 4.4 2.5 7.7 0.2 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF948 PF06103.6 AIC17286.1 - 0.38 10.6 1.9 1.9 8.3 0.3 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DASH_Dad2 PF08654.5 AIC17286.1 - 0.45 10.5 5.2 1.3 9.0 0.6 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad2 DUF972 PF06156.8 AIC17286.1 - 0.56 10.5 6.4 2 8.7 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF972) LPP20 PF02169.11 AIC17286.1 - 1.6 8.8 5.0 0.95 9.6 1.3 2.0 2 1 0 2 2 2 0 LPP20 lipoprotein DUF607 PF04678.8 AIC17286.1 - 1.7 8.5 6.9 2.3 8.0 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF607 DUF1178 PF06676.6 AIC17286.1 - 3 8.0 6.4 0.46 10.6 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) ABC_tran_2 PF12848.2 AIC17286.1 - 4.3 7.2 11.1 1.3 8.9 3.6 2.1 2 0 0 2 2 2 0 ABC transporter Med21 PF11221.3 AIC17286.1 - 5.9 6.8 9.6 0.34 10.8 1.0 2.3 2 1 0 2 2 2 0 Subunit 21 of Mediator complex SRP54 PF00448.17 AIC17287.1 - 5.1e-69 231.6 0.4 7.4e-69 231.1 0.3 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.14 AIC17287.1 - 6.4e-08 32.5 7.0 6.4e-08 32.5 4.8 2.3 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.1 AIC17287.1 - 3e-05 23.6 0.4 3e-05 23.6 0.3 1.8 2 0 0 2 2 1 1 AAA domain cobW PF02492.14 AIC17287.1 - 0.00017 21.1 0.1 0.00034 20.1 0.1 1.5 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain APS_kinase PF01583.15 AIC17287.1 - 0.00027 20.6 0.1 0.00072 19.2 0.0 1.7 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_22 PF13401.1 AIC17287.1 - 0.00031 20.9 0.0 0.00067 19.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain MobB PF03205.9 AIC17287.1 - 0.00083 19.0 1.7 0.0031 17.2 0.3 2.4 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_19 PF13245.1 AIC17287.1 - 0.0018 18.0 0.7 0.0035 17.0 0.5 1.5 1 0 0 1 1 1 1 Part of AAA domain AAA_16 PF13191.1 AIC17287.1 - 0.0053 16.7 0.3 0.018 15.0 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain CAF-1_p150 PF11600.3 AIC17287.1 - 0.0059 16.0 46.4 0.012 15.0 32.2 1.5 1 0 0 1 1 1 1 Chromatin assembly factor 1 complex p150 subunit, N-terminal Thymidylate_kin PF02223.12 AIC17287.1 - 0.0097 15.3 0.0 0.0097 15.3 0.0 2.8 2 1 0 2 2 1 1 Thymidylate kinase ArgK PF03308.11 AIC17287.1 - 0.041 12.6 3.1 0.27 9.9 2.1 2.3 1 1 0 1 1 1 0 ArgK protein AAA PF00004.24 AIC17287.1 - 0.059 13.5 0.3 0.16 12.1 0.2 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.1 AIC17287.1 - 0.062 13.1 0.0 0.062 13.1 0.0 2.4 2 0 0 2 2 1 0 AAA domain Zip PF02535.17 AIC17287.1 - 2.2 7.2 6.2 7.2 5.5 4.2 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter Caldesmon PF02029.10 AIC17287.1 - 3.6 5.8 45.2 6.7 4.9 31.4 1.3 1 0 0 1 1 1 0 Caldesmon OTCace_N PF02729.16 AIC17288.1 - 3.6e-52 175.7 0.0 5.3e-52 175.2 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.19 AIC17288.1 - 7.4e-50 168.8 0.0 1.1e-49 168.2 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain SNARE_assoc PF09335.6 AIC17289.1 - 6.7e-21 74.7 6.0 6.7e-21 74.7 4.2 2.4 2 1 0 2 2 2 1 SNARE associated Golgi protein GRA6 PF05084.8 AIC17289.1 - 0.042 13.3 0.1 0.064 12.7 0.1 1.3 1 0 0 1 1 1 0 Granule antigen protein (GRA6) P12 PF12669.2 AIC17289.1 - 0.13 12.4 0.8 0.13 12.4 0.5 2.5 3 0 0 3 3 3 0 Virus attachment protein p12 family RseC_MucC PF04246.7 AIC17289.1 - 2.1 7.9 9.6 0.6 9.6 0.3 2.8 2 2 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC DUF2545 PF10810.3 AIC17289.1 - 2.8 8.3 10.1 2.4 8.6 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2545) DUF763 PF05559.6 AIC17290.1 - 1e-112 376.2 0.0 1.2e-112 376.0 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF763) HHH PF00633.18 AIC17290.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif Rieske PF00355.21 AIC17291.1 - 3.1e-16 58.7 0.0 3.3e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.1 AIC17291.1 - 3.1e-07 30.0 0.0 4.1e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain DUF77 PF01910.12 AIC17292.1 - 1.5e-23 82.2 1.4 1.7e-23 82.0 1.0 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF77 Aldedh PF00171.17 AIC17292.1 - 0.26 9.5 2.3 0.38 9.0 1.6 1.4 1 1 0 1 1 1 0 Aldehyde dehydrogenase family CoatB PF10389.4 AIC17292.1 - 0.93 9.4 7.2 0.41 10.5 2.8 1.9 1 1 1 2 2 2 0 Bacteriophage coat protein B Tegument_dsDNA PF12818.2 AIC17293.1 - 0.023 13.5 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 dsDNA viral tegument protein DOT1 PF08123.8 AIC17294.1 - 7e-09 35.2 0.1 1.6e-07 30.8 0.0 2.2 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_18 PF12847.2 AIC17294.1 - 5.5e-08 33.3 0.0 8.3e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_26 PF13659.1 AIC17294.1 - 9e-08 32.1 0.0 1.3e-07 31.6 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.1 AIC17294.1 - 5.6e-05 22.7 0.0 8.2e-05 22.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.7 AIC17294.1 - 8.7e-05 22.9 0.0 0.00016 22.1 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.12 AIC17294.1 - 0.00022 20.3 0.0 0.0004 19.4 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase PrmA PF06325.8 AIC17294.1 - 0.00056 19.1 0.1 0.00075 18.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_25 PF13649.1 AIC17294.1 - 0.00057 20.1 0.0 0.00099 19.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.7 AIC17294.1 - 0.0022 18.4 0.0 0.0041 17.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.15 AIC17294.1 - 0.0029 16.6 0.0 0.0037 16.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase PCMT PF01135.14 AIC17294.1 - 0.0032 17.0 0.0 0.0065 16.0 0.0 1.6 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.9 AIC17294.1 - 0.0033 16.8 0.1 0.0075 15.6 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase small domain CMAS PF02353.15 AIC17294.1 - 0.0046 16.0 0.0 0.0064 15.5 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_23 PF13489.1 AIC17294.1 - 0.027 14.1 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PEPCK_ATP PF01293.15 AIC17298.1 - 5.5e-223 740.6 0.0 6.3e-223 740.4 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase PSD1 PF07587.6 AIC17298.1 - 0.058 12.7 0.0 0.096 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) AAA_33 PF13671.1 AIC17298.1 - 0.14 12.0 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain CheR_N PF03705.10 AIC17299.1 - 0.23 10.8 0.8 0.38 10.1 0.1 1.8 2 0 0 2 2 2 0 CheR methyltransferase, all-alpha domain CxxCxxCC PF03692.10 AIC17300.1 - 2.1e-08 34.4 0.2 7.2e-08 32.8 0.2 1.8 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain Sod_Fe_C PF02777.13 AIC17303.1 - 9.6e-41 137.9 2.1 1.4e-40 137.4 0.9 1.6 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.17 AIC17303.1 - 4.7e-29 100.4 1.5 4.7e-29 100.4 1.1 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Cna_B PF05738.8 AIC17304.1 - 0.0013 18.4 2.8 0.0018 18.0 0.0 2.6 3 0 0 3 3 3 1 Cna protein B-type domain