# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- Nitroreductase PF00881.24 AIC14184.1 - 1.3e-29 103.5 4.0 1.2e-27 97.0 4.0 2.1 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 AIC14184.1 - 1.2e-11 44.7 0.1 1.2e-05 25.0 0.2 3.1 1 1 2 3 3 3 3 Putative TM nitroreductase HMG_CoA_synt_C PF08540.10 AIC14187.1 - 4.8e-33 115.0 0.1 8.8e-33 114.1 0.1 1.4 1 1 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase C terminal HMG_CoA_synt_N PF01154.17 AIC14187.1 - 9.7e-29 100.5 0.0 2.2e-28 99.3 0.0 1.5 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A synthase N terminal PALP PF00291.25 AIC14188.1 - 1e-86 291.0 4.0 1.3e-86 290.7 4.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme ACT PF01842.25 AIC14188.1 - 0.00056 19.6 0.0 0.0013 18.4 0.0 1.7 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 AIC14188.1 - 0.02 15.5 0.0 0.047 14.3 0.0 1.6 1 0 0 1 1 1 0 ACT domain Thr_dehydrat_C PF00585.18 AIC14188.1 - 0.084 12.6 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 C-terminal regulatory domain of Threonine dehydratase CPSF_A PF03178.15 AIC14189.1 - 0.071 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 CPSF A subunit region DUF2024 PF09630.10 AIC14190.1 - 2.7e-35 120.1 1.9 3.1e-35 119.9 1.9 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) Lactamase_B PF00753.27 AIC14191.1 - 2.8e-21 76.4 2.2 6.4e-21 75.3 2.1 1.7 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIC14191.1 - 0.0052 16.3 0.3 0.01 15.3 0.3 1.6 1 1 0 1 1 1 1 Beta-lactamase superfamily domain NHL PF01436.21 AIC14192.1 - 6.4e-25 85.9 0.1 0.018 15.0 0.1 7.4 7 0 0 7 7 7 6 NHL repeat Thioredoxin_8 PF13905.6 AIC14192.1 - 4e-12 46.3 0.0 7.8e-12 45.4 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 AIC14192.1 - 6.2e-11 42.2 0.0 5.1e-10 39.2 0.0 2.2 2 0 0 2 2 2 1 Redoxin AhpC-TSA PF00578.21 AIC14192.1 - 1.6e-10 40.9 0.0 3.8e-10 39.8 0.0 1.6 1 0 0 1 1 1 1 AhpC/TSA family LVIVD PF08309.11 AIC14192.1 - 1.9e-06 27.1 1.8 0.29 10.5 0.0 5.3 6 0 0 6 6 6 2 LVIVD repeat ANAPC4_WD40 PF12894.7 AIC14192.1 - 3.7e-06 27.1 0.2 0.003 17.8 0.0 4.3 4 2 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain SGL PF08450.12 AIC14192.1 - 5.6e-06 26.1 0.1 0.039 13.5 0.0 3.9 3 1 1 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region Thioredoxin_2 PF13098.6 AIC14192.1 - 1.8e-05 25.1 0.0 3.3e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin PF00085.20 AIC14192.1 - 0.00051 20.0 0.7 0.15 12.0 0.2 2.7 2 1 0 3 3 3 1 Thioredoxin PQQ_3 PF13570.6 AIC14192.1 - 0.0053 17.2 0.1 1.4e+02 3.1 0.0 5.4 6 0 0 6 6 6 0 PQQ-like domain TrbC_Ftype PF09673.10 AIC14192.1 - 0.11 12.5 0.0 0.21 11.7 0.0 1.3 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein Lactonase PF10282.9 AIC14192.1 - 0.19 10.9 0.0 1.2 8.3 0.0 2.3 3 0 0 3 3 3 0 Lactonase, 7-bladed beta-propeller Nitroreductase PF00881.24 AIC14193.1 - 8.2e-21 74.8 0.8 3.4e-18 66.3 0.8 2.1 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 AIC14193.1 - 3.8e-08 33.2 0.0 0.0066 16.0 0.0 2.2 2 0 0 2 2 2 2 Putative TM nitroreductase DUF432 PF04254.13 AIC14194.1 - 1.5e-32 112.3 0.2 2.6e-32 111.6 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF432) CorA PF01544.18 AIC14195.1 - 3.2e-60 203.9 0.0 3.6e-60 203.8 0.0 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein TelA PF05816.11 AIC14195.1 - 0.063 12.3 0.4 0.12 11.4 0.3 1.4 1 1 0 1 1 1 0 Toxic anion resistance protein (TelA) FeoB_Cyto PF17910.1 AIC14195.1 - 0.11 13.1 0.1 2.7 8.6 0.0 2.3 2 0 0 2 2 2 0 FeoB cytosolic helical domain MS_channel PF00924.18 AIC14196.1 - 1.8e-48 164.9 0.1 1.8e-48 164.9 0.1 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel HeH PF12949.7 AIC14196.1 - 0.026 14.2 0.1 0.54 10.0 0.0 2.5 2 0 0 2 2 2 0 HeH/LEM domain Sdh_cyt PF01127.22 AIC14196.1 - 0.065 13.3 0.4 0.065 13.3 0.4 1.7 2 0 0 2 2 2 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit MFS_1 PF07690.16 AIC14197.1 - 1.1e-29 103.4 39.9 2.3e-18 66.3 14.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily FRP PF18032.1 AIC14199.1 - 0.046 14.3 0.1 0.26 11.9 0.0 2.1 2 0 0 2 2 2 0 Photoprotection regulator fluorescence recovery protein AAA PF00004.29 AIC14199.1 - 0.074 13.5 3.9 0.36 11.2 1.0 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) HigB_toxin PF09907.9 AIC14200.1 - 0.0018 18.5 0.0 0.0032 17.6 0.0 1.4 1 0 0 1 1 1 1 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system ParE_toxin PF05016.15 AIC14200.1 - 0.0075 16.9 0.1 0.012 16.3 0.1 1.4 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE Guanylate_cyc PF00211.20 AIC14201.1 - 3e-18 66.1 0.0 4.3e-18 65.6 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Ribosomal_S9 PF00380.19 AIC14202.1 - 1.9e-27 96.2 0.3 2.3e-27 95.9 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S9/S16 Ribosomal_L13 PF00572.18 AIC14203.1 - 1.3e-10 41.6 0.7 1e-08 35.5 0.7 2.1 1 1 0 1 1 1 1 Ribosomal protein L13 Ribosomal_L18 PF17135.4 AIC14204.1 - 5.1e-11 42.3 0.0 5.6e-11 42.2 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L27A PF00828.19 AIC14204.1 - 6.6e-08 33.3 0.1 9.7e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L1 PF00687.21 AIC14204.1 - 0.012 15.3 0.0 0.015 15.0 0.0 1.2 1 1 0 1 1 1 0 Ribosomal protein L1p/L10e family RNA_pol_A_bac PF01000.26 AIC14205.1 - 2.6e-27 95.4 0.0 6.3e-27 94.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain RNA_pol_L PF01193.24 AIC14205.1 - 3.3e-15 55.3 0.0 4.6e-15 54.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L_2 PF13656.6 AIC14205.1 - 0.012 15.3 0.1 0.025 14.4 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Thioredoxin_3 PF13192.6 AIC14205.1 - 0.21 11.6 2.9 8 6.6 0.1 2.9 2 1 0 2 2 2 0 Thioredoxin domain SBDS PF01172.18 AIC14206.1 - 5e-21 74.6 0.0 8e-21 73.9 0.0 1.3 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 AIC14206.1 - 6e-18 65.0 0.0 9.7e-18 64.3 0.0 1.3 1 0 0 1 1 1 1 SBDS protein C-terminal domain DUF3095 PF11294.8 AIC14206.1 - 0.026 13.6 0.0 0.061 12.4 0.0 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3095) HD_assoc PF13286.6 AIC14206.1 - 0.042 14.4 1.7 0.7 10.5 0.4 2.9 1 1 2 3 3 3 0 Phosphohydrolase-associated domain Myc_N PF01056.18 AIC14206.1 - 0.044 13.7 0.1 0.058 13.3 0.1 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Phage_TAC_5 PF08890.11 AIC14206.1 - 0.073 13.1 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 Phage XkdN-like tail assembly chaperone protein, TAC KH_1 PF00013.29 AIC14207.1 - 3.4e-10 39.6 2.3 5.6e-10 38.9 2.3 1.4 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 AIC14207.1 - 0.00019 21.2 1.2 0.00045 20.0 0.6 1.9 1 1 1 2 2 2 1 KH domain KH_6 PF15985.5 AIC14207.1 - 0.018 15.4 0.0 0.03 14.7 0.0 1.4 1 0 0 1 1 1 0 KH domain Herpes_capsid PF06112.11 AIC14207.1 - 0.093 12.8 2.0 0.14 12.3 2.0 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein RNase_PH PF01138.21 AIC14208.1 - 2.3e-34 118.7 0.0 3.2e-34 118.3 0.0 1.2 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AIC14208.1 - 2.3e-14 53.2 0.1 6.4e-14 51.7 0.1 1.8 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 RNase_PH PF01138.21 AIC14209.1 - 2.4e-26 92.8 0.0 3.8e-26 92.1 0.0 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 AIC14209.1 - 6.7e-08 32.5 0.0 1.5e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 Ribosomal_L37ae PF01780.19 AIC14210.1 - 3.2e-16 59.2 0.5 3.5e-16 59.0 0.5 1.0 1 0 0 1 1 1 1 Ribosomal L37ae protein family Zn_Tnp_IS1595 PF12760.7 AIC14210.1 - 7.2e-05 22.7 3.5 9.9e-05 22.2 3.5 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 AIC14210.1 - 0.0036 16.7 1.7 0.074 12.5 0.1 2.3 2 0 0 2 2 2 1 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIC14210.1 - 0.023 14.6 0.8 0.029 14.3 0.8 1.3 1 1 0 1 1 1 0 Putative transposase DNA-binding domain C1_1 PF00130.22 AIC14210.1 - 0.034 14.0 0.8 0.044 13.7 0.8 1.1 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Rubredoxin PF00301.20 AIC14210.1 - 0.039 14.0 0.6 4.5 7.4 0.3 2.2 2 0 0 2 2 2 0 Rubredoxin zf-RanBP PF00641.18 AIC14210.1 - 0.048 13.0 3.9 0.28 10.5 0.6 2.1 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zf-tcix PF14952.6 AIC14210.1 - 0.049 13.2 3.4 1.4 8.6 0.4 2.2 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zinc_ribbon_4 PF13717.6 AIC14210.1 - 0.062 13.2 0.9 8.9 6.3 0.0 2.4 2 0 0 2 2 2 0 zinc-ribbon domain VP_N-CPKC PF11475.8 AIC14210.1 - 0.066 13.1 1.7 1.3 9.0 0.2 2.2 2 0 0 2 2 2 0 Virion protein N terminal domain TackOD1 PF18551.1 AIC14210.1 - 0.085 12.5 0.6 0.17 11.5 0.6 1.5 1 1 0 1 1 1 0 Thaumarchaeal output domain 1 zinc_ribbon_2 PF13240.6 AIC14210.1 - 0.094 12.5 2.5 5.7 6.8 0.3 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF35_N PF12172.8 AIC14210.1 - 0.23 11.4 0.5 0.23 11.4 0.5 2.0 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-C4_Topoisom PF01396.19 AIC14210.1 - 0.23 11.3 4.0 5 7.0 0.1 2.7 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger Zn-ribbon_8 PF09723.10 AIC14210.1 - 0.32 11.1 0.3 0.32 11.1 0.3 2.2 1 1 1 2 2 2 0 Zinc ribbon domain zf-C2H2_3 PF13878.6 AIC14210.1 - 0.52 10.2 2.0 13 5.7 0.0 2.2 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO DNA_ligase_ZBD PF03119.16 AIC14210.1 - 3.1 7.9 7.8 1.6 8.8 0.7 2.7 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Rubredoxin_2 PF18073.1 AIC14210.1 - 3.6 7.4 8.6 11 5.8 1.6 2.6 3 0 0 3 3 3 0 Rubredoxin metal binding domain Pcc1 PF09341.10 AIC14211.1 - 3.1e-09 36.8 0.0 3.4e-09 36.7 0.0 1.0 1 0 0 1 1 1 1 Transcription factor Pcc1 Prefoldin_2 PF01920.20 AIC14212.1 - 3.5e-17 62.3 9.5 3.8e-17 62.2 9.5 1.0 1 0 0 1 1 1 1 Prefoldin subunit DUF1690 PF07956.11 AIC14212.1 - 0.12 12.8 3.7 0.095 13.1 2.5 1.5 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) Nup88 PF10168.9 AIC14212.1 - 0.42 8.4 3.0 0.41 8.4 3.0 1.0 1 0 0 1 1 1 0 Nuclear pore component KIP1 PF07765.12 AIC14212.1 - 1.5 9.0 5.3 9.1 6.5 0.1 2.1 2 0 0 2 2 2 0 KIP1-like protein ERCC4 PF02732.15 AIC14213.1 - 6.1e-21 75.3 0.0 8.2e-21 74.8 0.0 1.2 1 0 0 1 1 1 1 ERCC4 domain HHH_5 PF14520.6 AIC14213.1 - 2.6e-11 43.9 0.4 4.2e-10 40.1 0.0 2.4 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_2 PF12826.7 AIC14213.1 - 4.9e-05 23.4 0.0 0.00013 22.0 0.0 1.7 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH PF00633.23 AIC14213.1 - 0.00021 21.0 0.1 0.77 9.7 0.0 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_8 PF14716.6 AIC14213.1 - 0.0034 17.7 0.1 1.7 9.1 0.0 3.2 2 1 1 3 3 3 2 Helix-hairpin-helix domain IMS_HHH PF11798.8 AIC14213.1 - 0.0039 17.5 0.0 0.065 13.6 0.0 2.6 2 0 0 2 2 2 1 IMS family HHH motif HHH_3 PF12836.7 AIC14213.1 - 0.0052 17.0 0.1 3.3 8.0 0.0 2.5 2 0 0 2 2 2 2 Helix-hairpin-helix motif 5_3_exonuc PF01367.20 AIC14213.1 - 0.0088 16.6 0.1 0.12 12.9 0.0 2.3 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold Transposase_20 PF02371.16 AIC14213.1 - 0.034 14.4 0.0 0.38 11.1 0.0 2.4 1 1 1 2 2 2 0 Transposase IS116/IS110/IS902 family EspB_PE PF18625.1 AIC14213.1 - 0.053 14.0 0.2 0.13 12.8 0.2 1.6 1 0 0 1 1 1 0 ESX-1 secreted protein B PE domain DUF3701 PF12482.8 AIC14213.1 - 0.099 12.7 0.0 7.7 6.7 0.0 2.4 1 1 1 2 2 2 0 Phage integrase protein Cdd1 PF11731.8 AIC14213.1 - 0.2 11.9 0.1 38 4.6 0.0 2.8 3 0 0 3 3 3 0 Pathogenicity locus PHA_synth_III_E PF09712.10 AIC14213.1 - 0.21 10.7 0.0 0.3 10.1 0.0 1.2 1 0 0 1 1 1 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Rhodanese PF00581.20 AIC14214.1 - 1.4e-31 109.2 0.0 7e-15 55.5 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain PIN_6 PF17146.4 AIC14215.1 - 8e-17 61.5 0.3 1.3e-16 60.9 0.3 1.3 1 0 0 1 1 1 1 PIN domain of ribonuclease PIN_5 PF08745.11 AIC14215.1 - 0.00025 20.6 0.3 0.00046 19.7 0.3 1.4 1 0 0 1 1 1 1 PINc domain ribonuclease PIN PF01850.21 AIC14215.1 - 0.00045 20.7 2.0 0.00083 19.8 2.0 1.5 1 1 0 1 1 1 1 PIN domain NOB1_Zn_bind PF08772.11 AIC14215.1 - 0.0014 18.7 1.5 0.0023 18.0 1.5 1.4 1 0 0 1 1 1 1 Nin one binding (NOB1) Zn-ribbon like DZR PF12773.7 AIC14215.1 - 0.0032 17.5 1.0 0.0059 16.6 1.0 1.3 1 0 0 1 1 1 1 Double zinc ribbon HypA PF01155.19 AIC14215.1 - 0.013 15.5 0.7 0.023 14.7 0.7 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C3HC4_3 PF13920.6 AIC14215.1 - 0.016 15.1 1.1 0.026 14.4 1.1 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-ribbon_3 PF13248.6 AIC14215.1 - 0.022 14.2 1.8 0.045 13.2 1.8 1.5 1 0 0 1 1 1 0 zinc-ribbon domain RecR PF02132.15 AIC14215.1 - 0.1 12.2 0.2 0.25 10.9 0.2 1.7 1 0 0 1 1 1 0 RecR protein Ribosomal_L37e PF01907.19 AIC14215.1 - 0.15 12.2 2.4 0.24 11.6 2.4 1.3 1 0 0 1 1 1 0 Ribosomal protein L37e Zn-ribbon_8 PF09723.10 AIC14215.1 - 0.18 12.0 4.5 0.21 11.7 3.1 1.9 2 1 0 2 2 1 0 Zinc ribbon domain NRDD PF13597.6 AIC14215.1 - 0.18 10.5 0.2 0.22 10.3 0.2 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase Nudix_N_2 PF14803.6 AIC14215.1 - 0.19 11.7 2.8 11 6.0 0.3 2.3 2 0 0 2 2 2 0 Nudix N-terminal DUF2116 PF09889.9 AIC14215.1 - 0.24 11.4 0.9 0.42 10.6 0.9 1.4 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Zn_ribbon_recom PF13408.6 AIC14215.1 - 0.24 12.0 2.4 22 5.6 2.4 2.7 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain Zn_ribbon_SprT PF17283.2 AIC14215.1 - 0.29 11.1 3.5 2.3 8.2 2.6 2.2 1 1 1 2 2 2 0 SprT-like zinc ribbon domain DUF35_N PF12172.8 AIC14215.1 - 1 9.3 4.6 0.33 10.9 1.5 1.7 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) NAD_kinase PF01513.21 AIC14216.1 - 1.1e-29 103.5 1.1 1.8e-29 102.9 1.1 1.4 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 AIC14216.1 - 0.058 13.0 0.1 0.1 12.2 0.1 1.4 1 0 0 1 1 1 0 Diacylglycerol kinase catalytic domain Rhodanese PF00581.20 AIC14217.1 - 4e-39 133.4 0.1 3.1e-19 69.5 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Fer4 PF00037.27 AIC14219.1 - 1.1e-08 34.6 17.9 0.0002 21.0 3.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIC14219.1 - 4.6e-06 27.1 8.6 6.4e-06 26.7 7.5 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain ETF_QO PF05187.13 AIC14219.1 - 2.3e-05 24.5 0.7 5e-05 23.4 0.7 1.5 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_9 PF13187.6 AIC14219.1 - 2.3e-05 24.5 7.6 4.6e-05 23.5 7.6 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIC14219.1 - 0.0002 21.4 9.3 0.00053 20.1 9.2 1.8 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIC14219.1 - 0.00027 21.0 8.2 0.00047 20.2 8.2 1.4 1 0 0 1 1 1 1 4Fe-4S dicluster domain Tenui_PVC2 PF06656.11 AIC14219.1 - 0.0032 15.5 0.0 0.0059 14.6 0.0 1.3 1 0 0 1 1 1 1 Tenuivirus PVC2 protein Fer4_8 PF13183.6 AIC14219.1 - 0.022 15.2 6.9 0.07 13.6 6.6 2.0 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIC14219.1 - 0.026 14.6 13.3 0.42 10.8 1.9 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Sec66 PF09802.9 AIC14219.1 - 0.09 12.3 0.1 0.14 11.7 0.1 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 Fer4_17 PF13534.6 AIC14219.1 - 0.093 13.3 5.3 2.2 8.9 0.8 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIC14219.1 - 0.11 13.5 15.4 0.97 10.5 5.1 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_16 PF13484.6 AIC14219.1 - 0.28 12.1 13.3 1.4 9.9 3.1 2.8 2 1 1 3 3 2 0 4Fe-4S double cluster binding domain MSA-2c PF12238.8 AIC14219.1 - 0.39 10.7 2.4 0.54 10.2 2.4 1.2 1 0 0 1 1 1 0 Merozoite surface antigen 2c Fer4_13 PF13370.6 AIC14219.1 - 0.67 10.5 10.6 0.96 10.0 1.0 2.8 3 0 0 3 3 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_2 PF12797.7 AIC14219.1 - 2.7 8.3 13.8 7.6 6.9 2.2 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain CTP_transf_like PF01467.26 AIC14220.1 - 1.7e-15 57.4 0.0 2.4e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like FAD_syn PF06574.12 AIC14220.1 - 0.0052 16.7 0.3 0.014 15.3 0.1 1.7 2 0 0 2 2 2 1 FAD synthetase tRNA-synt_1b PF00579.25 AIC14223.1 - 2.5e-21 76.3 0.0 4.5e-21 75.4 0.0 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) tRNA-synt_1f PF01921.18 AIC14223.1 - 0.053 12.4 0.0 0.1 11.5 0.0 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (K) tRNA-synt_2d PF01409.20 AIC14224.1 - 1.7e-84 283.1 0.0 2.2e-84 282.8 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA_synthFbeta PF17759.1 AIC14224.1 - 8.5e-07 28.6 0.0 5.2e-05 22.8 0.0 2.6 3 0 0 3 3 3 1 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 AIC14224.1 - 0.0012 18.0 0.2 0.026 13.6 0.0 2.6 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 AIC14224.1 - 0.012 15.6 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) HTH_15 PF12324.8 AIC14224.1 - 0.015 15.2 0.1 0.12 12.4 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase HTH_20 PF12840.7 AIC14224.1 - 0.018 15.1 0.0 0.061 13.4 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain PheRS_DBD3 PF18553.1 AIC14224.1 - 0.028 14.7 0.2 0.11 12.8 0.1 2.1 2 0 0 2 2 2 0 PheRS DNA binding domain 3 PheRS_DBD1 PF18552.1 AIC14224.1 - 0.26 11.1 1.4 1.7 8.4 0.3 2.4 2 0 0 2 2 2 0 PheRS DNA binding domain 1 tRNA_synthFbeta PF17759.1 AIC14225.1 - 7.2e-39 133.4 0.0 1.3e-38 132.6 0.0 1.4 1 0 0 1 1 1 1 Phenylalanyl tRNA synthetase beta chain CLM domain B5 PF03484.15 AIC14225.1 - 1e-17 64.1 0.0 4.9e-16 58.8 0.0 2.8 3 0 0 3 3 3 1 tRNA synthetase B5 domain B3_4 PF03483.17 AIC14225.1 - 1.2e-13 51.1 0.0 2.1e-13 50.3 0.0 1.3 1 0 0 1 1 1 1 B3/4 domain KOW PF00467.29 AIC14225.1 - 2.2 8.3 6.0 1.2 9.2 0.4 3.0 3 0 0 3 3 3 0 KOW motif NFACT-R_2 PF18297.1 AIC14226.1 - 9.7e-23 80.3 0.0 1.7e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain ThiI PF02568.14 AIC14226.1 - 3.3e-14 52.9 0.0 5.5e-14 52.2 0.0 1.2 1 0 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 AIC14226.1 - 1.1e-12 47.4 0.0 3.3e-12 45.9 0.0 1.7 2 0 0 2 2 2 1 tRNA methyl transferase NFACT-R_1 PF05670.13 AIC14226.1 - 0.00034 21.2 0.0 0.00085 20.0 0.0 1.6 1 0 0 1 1 1 1 NFACT protein RNA binding domain Asn_synthase PF00733.21 AIC14226.1 - 0.0013 18.5 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 AIC14226.1 - 0.0018 17.8 0.0 0.0037 16.8 0.0 1.6 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC HTH_23 PF13384.6 AIC14226.1 - 0.075 12.9 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 Homeodomain-like domain NAD_synthase PF02540.17 AIC14226.1 - 0.094 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 NAD synthase SepF PF04472.12 AIC14227.1 - 4.9e-14 52.4 0.1 5.7e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 Cell division protein SepF KH_7 PF17214.3 AIC14228.1 - 3.3e-23 81.4 0.1 3.1e-21 75.1 0.2 2.8 2 0 0 2 2 2 1 KH domain Beta-Casp PF10996.8 AIC14228.1 - 8.9e-17 61.4 0.0 1.9e-15 57.1 0.0 2.7 3 0 0 3 3 3 1 Beta-Casp domain Lactamase_B PF00753.27 AIC14228.1 - 1.1e-13 51.6 0.2 2.7e-13 50.4 0.2 1.5 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily RMMBL PF07521.12 AIC14228.1 - 1.1e-12 47.7 0.0 2.7e-12 46.4 0.0 1.7 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_6 PF16661.5 AIC14228.1 - 2.2e-11 43.5 0.0 4.6e-11 42.5 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 AIC14228.1 - 3.8e-09 36.3 0.1 6.4e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIC14228.1 - 0.0031 17.4 0.0 0.0085 16.0 0.0 1.7 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TRAM PF01938.20 AIC14229.1 - 5.2e-12 45.6 0.5 6.7e-12 45.2 0.5 1.2 1 0 0 1 1 1 1 TRAM domain Fe-ADH_2 PF13685.6 AIC14230.1 - 2.8e-63 213.9 0.1 4.1e-63 213.4 0.1 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 AIC14230.1 - 1.9e-23 82.9 0.5 3.5e-22 78.7 0.5 2.0 1 1 0 1 1 1 1 Iron-containing alcohol dehydrogenase DHQ_synthase PF01761.20 AIC14230.1 - 2.8e-07 30.0 0.1 7.7e-06 25.2 0.1 2.7 1 1 0 1 1 1 1 3-dehydroquinate synthase AIRC PF00731.20 AIC14230.1 - 0.025 14.2 0.3 0.072 12.7 0.0 1.9 2 0 0 2 2 2 0 AIR carboxylase Polyketide_cyc PF03364.20 AIC14231.1 - 1.8e-09 37.9 0.0 2.3e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc2 PF10604.9 AIC14231.1 - 1.8e-07 31.5 0.1 2.3e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport DUF99 PF01949.16 AIC14232.1 - 4.4e-61 205.5 0.1 5.1e-61 205.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF99 GTP_EFTU_D2 PF03144.25 AIC14233.1 - 2.9e-07 30.8 0.1 6e-07 29.8 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 AIC14233.1 - 0.058 13.3 0.1 0.17 11.8 0.1 1.8 1 1 0 1 1 1 0 Elongation factor Tu domain 4 PKD PF00801.20 AIC14234.1 - 3e-14 52.6 1.1 6.1e-14 51.6 1.1 1.5 1 0 0 1 1 1 1 PKD domain COX4 PF02936.14 AIC14234.1 - 0.028 14.4 0.0 0.07 13.1 0.0 1.6 2 0 0 2 2 2 0 Cytochrome c oxidase subunit IV Cu-oxidase_3 PF07732.15 AIC14236.1 - 9.1e-13 48.3 0.5 1.9e-12 47.2 0.5 1.6 1 0 0 1 1 1 1 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIC14236.1 - 2.5e-08 33.8 2.7 0.0022 17.7 0.1 3.2 3 0 0 3 3 3 3 Multicopper oxidase Cupredoxin_1 PF13473.6 AIC14236.1 - 0.0014 18.7 0.0 0.003 17.6 0.0 1.5 1 0 0 1 1 1 1 Cupredoxin-like domain AmoC PF04896.12 AIC14237.1 - 5.1e-14 52.1 7.9 6.2e-14 51.9 7.9 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C zinc_ribbon_4 PF13717.6 AIC14238.1 - 0.092 12.7 1.1 7.7 6.5 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_5 PF13719.6 AIC14238.1 - 0.5 10.2 3.2 9.9 6.0 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain UPF0547 PF10571.9 AIC14238.1 - 9.7 6.4 9.0 5.4 7.2 1.0 2.9 2 1 1 3 3 3 0 Uncharacterised protein family UPF0547 DUF2393 PF09624.10 AIC14240.1 - 0.00058 19.9 0.0 0.0013 18.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2393) CARDB PF07705.11 AIC14240.1 - 0.022 15.0 0.3 0.063 13.5 0.2 1.8 2 0 0 2 2 2 0 CARDB VAPB_antitox PF02697.14 AIC14241.1 - 0.0034 18.1 0.3 0.035 14.9 0.3 2.0 1 1 0 1 1 1 1 Putative antitoxin CheX PF13690.6 AIC14241.1 - 0.1 12.8 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX Zip PF02535.22 AIC14242.1 - 5.2e-09 35.8 11.4 5.2e-09 35.8 11.4 3.0 1 1 2 3 3 3 1 ZIP Zinc transporter Cu-oxidase_2 PF07731.14 AIC14243.1 - 1.2e-28 99.5 4.2 6e-14 52.0 0.2 3.1 3 0 0 3 3 3 3 Multicopper oxidase Cu-oxidase_3 PF07732.15 AIC14243.1 - 4.2e-27 94.5 3.6 7.7e-24 84.0 0.1 2.5 2 1 0 2 2 2 2 Multicopper oxidase Cupredoxin_1 PF13473.6 AIC14243.1 - 0.00024 21.2 0.1 0.016 15.3 0.0 2.5 3 0 0 3 3 3 1 Cupredoxin-like domain DUF309 PF03745.14 AIC14244.1 - 8.2e-17 60.6 0.9 1.5e-16 59.8 0.5 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF309) DUF3426 PF11906.8 AIC14245.1 - 0.00022 21.4 0.0 0.023 14.9 0.0 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF3426) Pribosyltran_N PF13793.6 AIC14246.1 - 5.5e-30 103.7 0.2 4.9e-28 97.4 0.0 2.3 2 0 0 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyl_synth PF14572.6 AIC14246.1 - 8e-20 71.6 3.0 1.3e-18 67.7 1.0 2.8 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain Pribosyltran PF00156.27 AIC14246.1 - 7.6e-14 51.5 0.5 2.8e-13 49.7 0.3 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIC14246.1 - 2.9e-06 26.9 0.0 4.5e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Lactamase_B_2 PF12706.7 AIC14247.1 - 7.8e-21 74.5 0.0 5.3e-10 39.2 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AIC14247.1 - 1.6e-06 28.3 0.0 5.3e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 AIC14247.1 - 0.00039 20.0 0.0 0.00077 19.1 0.0 1.5 1 0 0 1 1 1 1 tRNase Z endonuclease NAD_binding_10 PF13460.6 AIC14247.1 - 0.091 12.6 0.1 0.13 12.1 0.1 1.2 1 0 0 1 1 1 0 NAD(P)H-binding Metallophos PF00149.28 AIC14248.1 - 1.8e-22 80.9 0.1 2.7e-22 80.3 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AIC14248.1 - 0.00018 21.7 0.0 0.00037 20.7 0.0 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Lact_bio_phlase PF09508.10 AIC14248.1 - 0.098 11.1 0.0 0.15 10.4 0.0 1.2 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain Ribosomal_L32e PF01655.18 AIC14250.1 - 1.2e-37 128.6 0.1 1.5e-37 128.3 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L32 Ribosomal_L19e PF01280.20 AIC14251.1 - 2.8e-41 141.0 9.2 3.1e-41 140.8 9.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L19e HTH_12 PF08461.10 AIC14251.1 - 0.0059 16.5 0.3 0.012 15.5 0.3 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain DNA_binding_1 PF01035.20 AIC14252.1 - 8.2e-31 106.0 0.0 1.2e-30 105.4 0.0 1.2 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain tRNA_deacylase PF04414.12 AIC14253.1 - 6.2e-61 205.5 0.0 7.2e-61 205.3 0.0 1.0 1 0 0 1 1 1 1 D-aminoacyl-tRNA deacylase Spt5-NGN PF03439.13 AIC14254.1 - 9e-22 76.8 0.0 1.4e-21 76.2 0.0 1.3 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section KOW PF00467.29 AIC14254.1 - 8.2e-08 31.9 0.1 1.7e-07 30.9 0.1 1.5 1 0 0 1 1 1 1 KOW motif BNIP2 PF12496.8 AIC14254.1 - 0.03 14.8 2.2 0.047 14.1 2.2 1.3 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 NAD_binding_7 PF13241.6 AIC14255.1 - 3e-20 72.6 0.0 6.6e-20 71.5 0.0 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Sirohm_synth_M PF14824.6 AIC14255.1 - 5e-07 29.0 0.5 5e-07 29.0 0.5 1.9 2 0 0 2 2 2 1 Sirohaem biosynthesis protein central Shikimate_DH PF01488.20 AIC14255.1 - 0.00077 19.5 0.1 0.0024 17.9 0.0 1.9 3 0 0 3 3 3 1 Shikimate / quinate 5-dehydrogenase CysG_dimeriser PF10414.9 AIC14255.1 - 0.0035 17.0 0.1 0.0089 15.7 0.0 1.8 2 0 0 2 2 2 1 Sirohaem synthase dimerisation region TrkA_N PF02254.18 AIC14255.1 - 0.006 16.8 0.0 0.011 16.0 0.0 1.6 1 0 0 1 1 1 1 TrkA-N domain Pyr_redox PF00070.27 AIC14255.1 - 0.013 16.1 0.8 0.052 14.1 0.1 2.2 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase GlutR_N PF05201.15 AIC14256.1 - 2.1e-37 128.1 0.2 4.7e-37 127.0 0.2 1.5 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, N-terminal domain Shikimate_DH PF01488.20 AIC14256.1 - 7.4e-30 103.8 0.5 4.5e-29 101.3 0.0 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase GlutR_dimer PF00745.20 AIC14256.1 - 6.7e-17 61.7 0.1 1.4e-16 60.7 0.1 1.6 1 0 0 1 1 1 1 Glutamyl-tRNAGlu reductase, dimerisation domain 2-Hacid_dh_C PF02826.19 AIC14256.1 - 0.0018 17.7 0.0 0.0034 16.8 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF4147 PF13660.6 AIC14256.1 - 0.031 13.8 0.1 0.26 10.8 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4147) IlvN PF07991.12 AIC14256.1 - 0.048 13.2 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_7 PF13241.6 AIC14256.1 - 0.12 12.8 0.4 0.36 11.3 0.0 2.2 2 1 0 2 2 2 0 Putative NAD(P)-binding ALAD PF00490.21 AIC14257.1 - 5.6e-135 449.6 0.1 6.3e-135 449.4 0.1 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Luteo_Vpg PF01659.16 AIC14257.1 - 0.13 12.7 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 Luteovirus putative VPg genome linked protein PhnH PF05845.12 AIC14258.1 - 0.12 12.0 0.0 12 5.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial phosphonate metabolism protein (PhnH) RTX_C PF08339.10 AIC14259.1 - 0.015 15.4 1.8 0.64 10.1 0.2 2.1 1 1 1 2 2 2 0 RTX C-terminal domain Clr5 PF14420.6 AIC14261.1 - 0.036 14.3 0.2 0.058 13.6 0.2 1.4 1 0 0 1 1 1 0 Clr5 domain zf-FPG_IleRS PF06827.14 AIC14263.1 - 0.0066 16.3 0.9 0.011 15.6 0.9 1.4 1 0 0 1 1 1 1 Zinc finger found in FPG and IleRS Papilin_u7 PF16626.5 AIC14263.1 - 0.04 14.5 0.1 0.047 14.3 0.1 1.1 1 0 0 1 1 1 0 Linking region between Kunitz_BPTI and I-set on papilin Ribosomal_60s PF00428.19 AIC14263.1 - 1.9 9.1 7.6 2.4 8.8 7.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3481 PF11980.8 AIC14264.1 - 0.0077 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 C-terminal domain of neuropilin glycoprotein DUF3137 PF11335.8 AIC14264.1 - 0.032 14.2 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3137) Trp_oprn_chp PF09534.10 AIC14266.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.4 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) CD20 PF04103.15 AIC14266.1 - 0.12 12.4 0.8 0.25 11.4 0.2 1.7 1 1 1 2 2 2 0 CD20-like family AAA_22 PF13401.6 AIC14267.1 - 0.0081 16.4 0.2 0.057 13.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain T3SS_needle_F PF09392.10 AIC14268.1 - 0.11 12.7 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF Glyco_tranf_2_3 PF13641.6 AIC14269.1 - 3e-28 99.3 0.0 7.4e-28 98.0 0.0 1.7 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glycos_transf_2 PF00535.26 AIC14269.1 - 4.2e-21 75.5 0.0 7.7e-21 74.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_trans_2_3 PF13632.6 AIC14269.1 - 1e-19 71.3 1.2 1e-19 71.3 1.2 2.0 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIC14269.1 - 3.4e-16 59.2 0.1 6.6e-16 58.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Cellulose_synt PF03552.14 AIC14269.1 - 0.015 13.8 1.1 0.018 13.6 0.1 1.7 2 0 0 2 2 2 0 Cellulose synthase Chordopox_G3 PF06129.12 AIC14269.1 - 0.1 13.3 0.5 1.1 10.0 0.2 2.4 1 1 1 2 2 2 0 Chordopoxvirus G3 protein DUF1467 PF07330.12 AIC14269.1 - 0.25 11.3 2.2 11 6.0 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1467) DUF1129 PF06570.11 AIC14269.1 - 8.8 5.8 7.4 1 8.8 0.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1129) Fer4 PF00037.27 AIC14270.1 - 7.9e-08 31.8 22.9 0.00013 21.6 3.3 2.8 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIC14270.1 - 5.3e-06 26.9 8.1 5.3e-06 26.9 8.1 2.3 2 1 1 3 3 3 2 4Fe-4S dicluster domain ETF_QO PF05187.13 AIC14270.1 - 1.5e-05 25.0 0.5 1.5e-05 25.0 0.5 1.7 2 1 0 2 2 2 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_9 PF13187.6 AIC14270.1 - 2.5e-05 24.3 7.6 2.5e-05 24.3 7.6 2.4 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIC14270.1 - 0.00025 21.1 8.2 0.00025 21.1 8.2 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIC14270.1 - 0.00051 20.1 10.0 0.00051 20.1 10.0 2.1 2 1 1 3 3 3 2 4Fe-4S dicluster domain Tenui_PVC2 PF06656.11 AIC14270.1 - 0.0022 16.0 0.0 0.003 15.6 0.0 1.1 1 0 0 1 1 1 1 Tenuivirus PVC2 protein zinc_ribbon_11 PF11682.8 AIC14270.1 - 0.012 15.7 0.1 0.012 15.7 0.1 1.5 2 0 0 2 2 2 0 Probable zinc-ribbon Fer4_16 PF13484.6 AIC14270.1 - 0.11 13.5 13.6 0.73 10.8 3.0 2.9 2 1 1 3 3 3 0 4Fe-4S double cluster binding domain Fer4_8 PF13183.6 AIC14270.1 - 0.14 12.6 10.8 0.052 14.0 7.0 2.2 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIC14270.1 - 0.23 12.0 9.1 1.3 9.6 0.8 3.0 3 0 0 3 3 3 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIC14270.1 - 0.27 12.2 18.9 0.62 11.1 5.1 3.0 3 0 0 3 3 2 0 4Fe-4S binding domain DEC-1_N PF04625.13 AIC14270.1 - 1 8.3 8.1 1.4 7.9 8.1 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region Fer4_13 PF13370.6 AIC14270.1 - 1.9 9.1 13.4 0.61 10.7 1.0 2.9 3 0 0 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I MSA-2c PF12238.8 AIC14270.1 - 2.5 8.0 8.9 3.5 7.6 8.9 1.1 1 0 0 1 1 1 0 Merozoite surface antigen 2c Fer4_6 PF12837.7 AIC14270.1 - 3 8.1 22.5 0.27 11.4 1.9 3.1 4 0 0 4 4 3 0 4Fe-4S binding domain Fer4_18 PF13746.6 AIC14270.1 - 4.7 7.4 9.7 1.2 9.4 1.4 2.5 1 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIC14270.1 - 8 6.8 18.5 4.9 7.5 2.2 3.2 3 0 0 3 3 3 0 4Fe-4S binding domain TPP_enzyme_N PF02776.18 AIC14271.1 - 4.2e-49 166.5 1.7 4.3e-48 163.2 0.0 2.6 3 0 0 3 3 3 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_C PF02775.21 AIC14271.1 - 2.5e-42 144.2 0.5 1.8e-41 141.5 0.0 2.4 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 AIC14271.1 - 2.2e-31 108.4 0.1 4.3e-31 107.5 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain POR_N PF01855.19 AIC14271.1 - 0.00036 20.4 0.1 0.00072 19.4 0.1 1.5 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg Peptidase_M55 PF04951.13 AIC14271.1 - 0.12 11.8 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 D-aminopeptidase VIT1 PF01988.19 AIC14272.1 - 1.2e-11 44.9 10.6 1.6e-11 44.5 10.6 1.2 1 0 0 1 1 1 1 VIT family TrmB PF01978.19 AIC14273.1 - 6e-16 58.1 0.2 1.6e-15 56.7 0.1 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 AIC14273.1 - 2.2e-09 36.9 0.5 5.3e-05 22.5 0.1 2.2 2 0 0 2 2 2 2 Archaeal transcriptional regulator TrmB PLDc_2 PF13091.6 AIC14273.1 - 4e-06 26.8 0.5 0.054 13.4 0.0 3.5 3 2 1 4 4 4 2 PLD-like domain HTH_5 PF01022.20 AIC14273.1 - 0.00061 19.6 0.2 0.006 16.4 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIC14273.1 - 0.0019 18.1 0.2 0.0055 16.6 0.2 1.8 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 AIC14273.1 - 0.0036 17.1 0.7 0.034 13.9 0.4 2.6 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.22 AIC14273.1 - 0.0048 16.8 0.2 0.017 15.0 0.2 1.9 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 AIC14273.1 - 0.014 15.4 0.1 0.037 14.0 0.1 1.7 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Rrf2 PF02082.20 AIC14273.1 - 0.021 15.1 0.2 0.085 13.2 0.2 2.0 1 0 0 1 1 1 0 Transcriptional regulator PadR PF03551.14 AIC14273.1 - 0.026 14.5 0.0 0.08 12.9 0.0 1.8 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_27 PF13463.6 AIC14273.1 - 0.053 14.0 0.1 0.91 10.1 0.1 2.7 2 0 0 2 2 2 0 Winged helix DNA-binding domain HTH_24 PF13412.6 AIC14273.1 - 0.087 12.4 0.2 0.24 11.0 0.2 1.8 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding EccE PF11203.8 AIC14273.1 - 0.51 10.7 2.6 16 5.9 0.1 3.5 3 0 0 3 3 3 0 Putative type VII ESX secretion system translocon, EccE Peptidase_M10 PF00413.24 AIC14274.1 - 3.6e-14 52.9 0.0 6.5e-14 52.1 0.0 1.5 1 1 0 1 1 1 1 Matrixin DUF4953 PF16313.5 AIC14274.1 - 5.8e-05 22.4 0.0 9.2e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 Met-zincin Reprolysin_3 PF13582.6 AIC14274.1 - 0.00011 22.8 0.0 0.00015 22.2 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_5 PF13688.6 AIC14274.1 - 0.00093 19.4 0.2 0.0011 19.2 0.2 1.3 1 1 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_4 PF13583.6 AIC14274.1 - 0.00094 18.9 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 AIC14274.1 - 0.0017 18.0 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 Dual-action HEIGH metallo-peptidase Peptidase_M54 PF07998.11 AIC14274.1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase family M54 Reprolysin_2 PF13574.6 AIC14274.1 - 0.014 15.3 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF45 PF01863.17 AIC14274.1 - 0.015 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF45 Peptidase_M66 PF10462.9 AIC14274.1 - 0.028 13.4 0.1 0.047 12.7 0.1 1.3 1 0 0 1 1 1 0 Peptidase M66 Astacin PF01400.24 AIC14274.1 - 0.046 13.3 0.0 0.069 12.8 0.0 1.2 1 0 0 1 1 1 0 Astacin (Peptidase family M12A) Metallopep PF12044.8 AIC14274.1 - 0.18 10.4 0.2 0.26 9.8 0.2 1.2 1 0 0 1 1 1 0 Putative peptidase family TFIIA PF03153.13 AIC14275.1 - 0.66 9.9 25.0 0.97 9.4 25.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4106 PF13388.6 AIC14275.1 - 2.4 7.3 15.0 3.4 6.8 15.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) V4R PF02830.18 AIC14276.1 - 4.8e-13 48.9 0.1 8.7e-13 48.1 0.1 1.5 1 0 0 1 1 1 1 V4R domain HTH_24 PF13412.6 AIC14276.1 - 0.003 17.1 0.0 0.0057 16.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_CodY PF08222.11 AIC14276.1 - 0.0034 16.9 0.1 0.0093 15.5 0.1 1.7 1 0 0 1 1 1 1 CodY helix-turn-helix domain HTH_Crp_2 PF13545.6 AIC14276.1 - 0.015 15.3 0.0 0.028 14.4 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Rrf2 PF02082.20 AIC14276.1 - 0.037 14.4 0.0 0.064 13.6 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator DUF2507 PF10702.9 AIC14276.1 - 0.047 13.6 0.2 0.43 10.5 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2507) HTH_5 PF01022.20 AIC14276.1 - 0.063 13.2 0.0 0.13 12.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family DUF2749 PF10907.8 AIC14277.1 - 0.088 13.0 0.3 0.099 12.8 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) HemolysinCabind PF00353.19 AIC14281.1 - 2.5e-46 155.2 174.6 8.8e-11 41.6 19.1 7.9 4 1 5 9 9 9 9 RTX calcium-binding nonapeptide repeat (4 copies) PKD PF00801.20 AIC14281.1 - 5.5e-18 64.6 90.5 1.9e-06 27.6 7.4 9.5 9 0 0 9 9 9 8 PKD domain Y_Y_Y PF07495.13 AIC14281.1 - 6.1e-07 29.3 2.1 0.12 12.4 0.0 5.5 5 0 0 5 5 5 2 Y_Y_Y domain Lyase_N PF09092.11 AIC14281.1 - 0.075 12.9 0.0 12 5.7 0.0 4.1 5 0 0 5 5 5 0 Lyase, N terminal Big_7 PF17957.1 AIC14281.1 - 1.9 9.3 86.2 1.4 9.7 4.3 10.9 10 1 0 10 10 10 0 Bacterial Ig domain HemolysinCabind PF00353.19 AIC14282.1 - 7.1e-33 112.2 92.2 3.5e-10 39.7 13.4 4.2 1 1 5 6 6 6 6 RTX calcium-binding nonapeptide repeat (4 copies) PKD PF00801.20 AIC14282.1 - 2.1e-18 65.9 22.8 1.6e-09 37.5 2.3 4.8 4 0 0 4 4 4 4 PKD domain VCBS PF13517.6 AIC14282.1 - 0.00015 22.3 13.9 15 6.3 0.0 6.2 6 0 0 6 6 6 3 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella TcdB_toxin_midN PF12256.8 AIC14282.1 - 0.0011 18.3 5.6 4.8 6.5 0.0 4.1 4 0 0 4 4 4 3 Insecticide toxin TcdB middle/N-terminal region Big_7 PF17957.1 AIC14282.1 - 0.65 10.8 22.8 0.42 11.4 1.2 4.6 3 1 1 4 4 4 0 Bacterial Ig domain Dockerin_1 PF00404.18 AIC14282.1 - 3 8.1 9.8 35 4.7 0.1 4.8 5 0 0 5 5 5 0 Dockerin type I domain DUF11 PF01345.18 AIC14284.1 - 0.0023 18.2 0.0 0.017 15.4 0.0 2.2 1 1 0 1 1 1 1 Domain of unknown function DUF11 CBM49 PF09478.10 AIC14284.1 - 0.085 13.2 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Carbohydrate binding domain CBM49 HATPase_c PF02518.26 AIC14285.1 - 1.1e-25 90.3 0.0 3.1e-25 88.9 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIC14285.1 - 5.7e-18 65.6 1.0 6.8e-18 65.4 0.1 1.6 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 AIC14285.1 - 1e-11 44.7 0.4 1e-11 44.7 0.4 2.8 3 0 0 3 3 3 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 AIC14285.1 - 0.0024 17.8 0.0 0.0064 16.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c_3 PF13589.6 AIC14285.1 - 0.017 14.9 0.3 0.062 13.1 0.0 2.0 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MFS_Mycoplasma PF07672.13 AIC14285.1 - 0.074 12.3 0.2 0.074 12.3 0.2 1.6 2 0 0 2 2 2 0 Mycoplasma MFS transporter DUF4624 PF15417.6 AIC14285.1 - 0.076 12.8 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4624) GPDPase_memb PF10110.9 AIC14285.1 - 0.22 10.3 4.7 0.12 11.1 0.7 2.1 2 0 0 2 2 2 0 Membrane domain of glycerophosphoryl diester phosphodiesterase AI-2E_transport PF01594.16 AIC14285.1 - 0.83 8.7 5.8 1.3 8.1 1.7 2.2 2 0 0 2 2 2 0 AI-2E family transporter DUF1654 PF07867.11 AIC14286.1 - 0.044 13.5 0.1 0.081 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1654) RHH_1 PF01402.21 AIC14288.1 - 0.011 15.6 0.0 0.013 15.4 0.0 1.1 1 0 0 1 1 1 0 Ribbon-helix-helix protein, copG family TcA_TcB_BD PF18276.1 AIC14289.1 - 0.0083 15.3 0.1 0.0091 15.1 0.1 1.0 1 0 0 1 1 1 1 Tc toxin complex TcA C-terminal TcB-binding domain ParD_antitoxin PF03693.14 AIC14289.1 - 0.026 14.9 0.0 0.026 14.9 0.0 1.0 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH DUF4440 PF14534.6 AIC14290.1 - 2.5e-14 53.5 0.0 2.9e-14 53.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_2 PF12680.7 AIC14290.1 - 1.8e-06 28.5 0.0 2.2e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_3 PF13474.6 AIC14290.1 - 5.5e-06 26.6 0.0 7.5e-06 26.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_4 PF13577.6 AIC14290.1 - 0.00055 20.1 0.0 0.0011 19.1 0.0 1.5 1 1 0 1 1 1 1 SnoaL-like domain AAA_16 PF13191.6 AIC14294.1 - 1.4e-05 25.6 0.0 2.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ATPase_2 PF01637.18 AIC14294.1 - 6.9e-05 22.9 0.0 0.0004 20.4 0.0 1.9 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea NB-ARC PF00931.22 AIC14294.1 - 0.0024 17.1 0.0 0.004 16.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain ResIII PF04851.15 AIC14294.1 - 0.0064 16.5 0.0 0.0098 15.9 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_7 PF12775.7 AIC14294.1 - 0.016 14.8 0.0 0.038 13.5 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 AIC14294.1 - 0.041 14.3 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 AIC14294.1 - 0.054 13.1 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 AIC14294.1 - 0.1 11.7 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 AIC14294.1 - 0.15 12.0 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TFIIB PF00382.19 AIC14295.1 - 1.6e-08 34.5 0.7 4.1e-08 33.2 0.7 1.8 1 0 0 1 1 1 1 Transcription factor TFIIB repeat DUF4423 PF14394.6 AIC14295.1 - 2.1e-07 30.8 0.9 0.093 12.4 0.1 3.6 3 0 0 3 3 3 2 Domain of unknown function (DUF4423) TrmB PF01978.19 AIC14295.1 - 9.2e-06 25.5 0.8 0.057 13.3 0.0 4.1 4 0 0 4 4 4 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 AIC14295.1 - 0.00092 19.2 0.0 1.8 8.7 0.0 3.9 4 0 0 4 4 3 1 Helix-turn-helix domain HTH_27 PF13463.6 AIC14295.1 - 0.0014 19.1 0.5 33 5.1 0.0 4.4 5 0 0 5 5 5 0 Winged helix DNA-binding domain HTH_11 PF08279.12 AIC14295.1 - 0.0018 18.2 0.2 0.14 12.1 0.1 2.9 2 0 0 2 2 2 1 HTH domain HTH_24 PF13412.6 AIC14295.1 - 0.0026 17.3 2.2 0.0083 15.7 0.2 3.0 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_36 PF13730.6 AIC14295.1 - 0.0031 17.4 0.1 0.012 15.5 0.0 2.1 2 0 0 2 2 1 1 Helix-turn-helix domain Penicillinase_R PF03965.16 AIC14295.1 - 0.0042 17.4 0.6 0.33 11.3 0.0 3.0 3 0 0 3 3 2 1 Penicillinase repressor HTH_IclR PF09339.10 AIC14295.1 - 0.013 15.2 0.1 0.11 12.3 0.0 2.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain MarR_2 PF12802.7 AIC14295.1 - 0.022 14.7 0.2 5.5 7.0 0.0 3.9 4 1 1 5 5 5 0 MarR family HTH_29 PF13551.6 AIC14295.1 - 0.028 14.4 0.0 1 9.4 0.0 2.9 2 0 0 2 2 2 0 Winged helix-turn helix HTH_Crp_2 PF13545.6 AIC14295.1 - 0.04 13.9 0.1 1.1 9.3 0.1 2.6 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_43 PF09904.9 AIC14295.1 - 0.042 13.8 0.0 0.94 9.5 0.0 2.7 2 0 0 2 2 2 0 Winged helix-turn helix PaaX PF07848.12 AIC14295.1 - 0.043 14.1 0.3 0.28 11.4 0.0 2.5 2 0 0 2 2 2 0 PaaX-like protein HTH_41 PF14502.6 AIC14295.1 - 0.053 13.2 0.4 0.16 11.7 0.1 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain DprA_WH PF17782.1 AIC14295.1 - 0.089 12.9 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 DprA winged helix domain HTH_12 PF08461.10 AIC14295.1 - 0.1 12.5 0.8 0.89 9.6 0.1 2.6 2 0 0 2 2 2 0 Ribonuclease R winged-helix domain GntR PF00392.21 AIC14295.1 - 0.14 11.9 0.2 0.37 10.5 0.2 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family MarR PF01047.22 AIC14295.1 - 0.16 11.9 1.0 29 4.7 0.0 3.2 3 0 0 3 3 3 0 MarR family Sigma70_r4_2 PF08281.12 AIC14295.1 - 0.19 11.4 0.7 16 5.3 0.1 2.8 2 0 0 2 2 2 0 Sigma-70, region 4 HEAT_2 PF13646.6 AIC14296.1 - 1.4e-09 38.2 0.2 5.2e-05 23.6 0.0 3.1 2 1 0 3 3 3 2 HEAT repeats HEAT_PBS PF03130.16 AIC14296.1 - 3e-05 24.3 0.2 4.3 8.3 0.0 5.6 6 0 0 6 6 6 1 PBS lyase HEAT-like repeat YcbB PF08664.10 AIC14296.1 - 0.05 13.7 0.2 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 YcbB domain Ribosomal_L12 PF00542.19 AIC14296.1 - 0.088 13.2 0.3 3.6 8.0 0.0 2.5 2 0 0 2 2 2 0 Ribosomal protein L7/L12 C-terminal domain Mo25 PF08569.11 AIC14296.1 - 0.098 12.0 0.0 0.18 11.2 0.0 1.5 1 0 0 1 1 1 0 Mo25-like TrbC PF04956.13 AIC14297.1 - 0.0053 17.0 2.9 0.0077 16.4 2.9 1.4 1 1 0 1 1 1 1 TrbC/VIRB2 family ExbD PF02472.16 AIC14297.1 - 0.12 12.5 1.5 0.17 12.0 1.5 1.2 1 0 0 1 1 1 0 Biopolymer transport protein ExbD/TolR MLD PF11647.8 AIC14302.1 - 0.075 13.3 0.0 0.19 12.0 0.0 1.6 1 1 1 2 2 2 0 Membrane Localization Domain Phage_integrase PF00589.22 AIC14303.1 - 0.00015 21.6 0.0 0.0011 18.7 0.0 2.4 2 1 0 2 2 2 1 Phage integrase family HTH_38 PF13936.6 AIC14303.1 - 0.0015 18.3 0.3 0.0058 16.4 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain Baculo_gp41 PF04700.12 AIC14303.1 - 0.064 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Structural glycoprotein p40/gp41 conserved region HTH_5 PF01022.20 AIC14303.1 - 0.084 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family Ins_allergen_rp PF06757.13 AIC14303.1 - 0.12 12.3 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification DNA_methylase PF00145.17 AIC14305.1 - 5.6e-62 210.0 0.0 4.7e-61 207.0 0.0 2.0 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase HhH-GPD PF00730.25 AIC14306.1 - 1.1e-11 45.1 0.0 1.6e-11 44.6 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AIC14306.1 - 0.00017 21.2 0.1 0.00053 19.7 0.0 1.9 2 0 0 2 2 2 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 AIC14306.1 - 0.0037 17.6 3.1 0.0058 16.9 3.1 1.3 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III HHH_2 PF12826.7 AIC14306.1 - 0.06 13.4 0.0 5.1 7.3 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif TRAPPC9-Trs120 PF08626.11 AIC14306.1 - 0.12 9.6 0.1 0.13 9.6 0.1 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit IFT20 PF14931.6 AIC14306.1 - 0.16 12.2 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B, subunit 20 baeRF_family5 PF18846.1 AIC14308.1 - 0.045 14.0 0.0 0.079 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 5 Helicase_C PF00271.31 AIC14309.1 - 3.4e-10 40.2 0.0 1e-09 38.7 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AIC14309.1 - 1.5e-08 34.6 0.0 6.1e-06 26.1 0.0 3.0 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 AIC14309.1 - 0.0012 18.8 0.0 0.077 13.0 0.0 2.6 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit TniB PF05621.11 AIC14309.1 - 0.033 13.6 0.0 0.45 9.9 0.0 2.6 3 0 0 3 3 3 0 Bacterial TniB protein Zn_Tnp_IS1595 PF12760.7 AIC14310.1 - 0.0053 16.7 1.0 0.0053 16.7 1.0 3.6 4 0 0 4 4 4 1 Transposase zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIC14310.1 - 0.072 12.6 1.3 0.35 10.4 0.4 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding Ribosomal_L37ae PF01780.19 AIC14310.1 - 1.5 9.0 4.3 0.87 9.7 0.8 2.3 2 0 0 2 2 2 0 Ribosomal L37ae protein family Zn-ribbon_8 PF09723.10 AIC14310.1 - 2 8.6 14.5 0.54 10.4 0.2 3.9 3 2 1 4 4 4 0 Zinc ribbon domain A2L_zn_ribbon PF08792.10 AIC14310.1 - 2.5 7.9 7.5 0.4 10.5 2.7 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain OrfB_Zn_ribbon PF07282.11 AIC14310.1 - 7.5 6.6 12.6 0.15 12.0 0.9 3.4 3 1 1 4 4 4 0 Putative transposase DNA-binding domain PLDc_2 PF13091.6 AIC14311.1 - 1.8e-09 37.5 0.0 3.5e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 PLD-like domain DUF4136 PF13590.6 AIC14312.1 - 0.12 13.0 0.0 0.13 12.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4136) TPR_7 PF13176.6 AIC14312.1 - 0.15 12.1 0.1 0.38 10.9 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Response_reg PF00072.24 AIC14313.1 - 5.3e-24 84.5 1.1 2.9e-23 82.1 0.1 2.3 3 0 0 3 3 3 1 Response regulator receiver domain UPF0180 PF03698.13 AIC14313.1 - 0.00021 21.4 0.5 0.003 17.7 0.2 2.7 2 1 0 2 2 2 1 Uncharacterised protein family (UPF0180) HGTP_anticodon PF03129.20 AIC14313.1 - 0.099 12.8 0.2 0.32 11.2 0.0 1.9 2 0 0 2 2 2 0 Anticodon binding domain Thy1 PF02511.15 AIC14314.1 - 1.2e-34 119.7 1.0 3.9e-19 69.2 1.2 2.3 2 0 0 2 2 2 2 Thymidylate synthase complementing protein rpo132 PF12415.8 AIC14314.1 - 0.17 11.2 0.2 16 4.9 0.1 2.4 2 0 0 2 2 2 0 Poxvirus DNA dependent RNA polymerase ApoLp-III PF07464.11 AIC14315.1 - 0.0079 16.3 5.4 0.025 14.6 4.3 2.1 1 1 0 2 2 2 1 Apolipophorin-III precursor (apoLp-III) DivIVA PF05103.13 AIC14315.1 - 0.011 15.8 3.2 0.02 15.0 3.1 1.5 1 1 1 2 2 2 0 DivIVA protein TetR_C_18 PF17923.1 AIC14315.1 - 0.08 13.5 0.3 3.3 8.3 0.0 2.2 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain CdvA PF18822.1 AIC14316.1 - 1.2e-30 105.8 10.5 1.9e-30 105.2 10.5 1.3 1 0 0 1 1 1 1 CdvA-like coiled-coil domain PRC PF05239.16 AIC14316.1 - 0.011 15.9 1.9 0.024 14.7 0.9 2.1 2 0 0 2 2 2 0 PRC-barrel domain DUF3275 PF11679.8 AIC14316.1 - 0.064 13.2 4.5 0.081 12.9 3.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3275) TraC PF07820.12 AIC14316.1 - 0.11 12.9 1.3 0.28 11.5 1.3 1.7 1 0 0 1 1 1 0 TraC-like protein HAUS-augmin3 PF14932.6 AIC14316.1 - 0.58 9.7 9.4 0.27 10.8 5.2 1.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 COX1 PF00115.20 AIC14317.1 - 1.6e-135 452.3 59.7 1.9e-135 452.1 59.7 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DHHC PF01529.20 AIC14318.1 - 7.7 6.6 9.1 1.2 9.3 3.3 2.1 1 1 0 2 2 2 0 DHHC palmitoyltransferase Flavin_Reduct PF01613.18 AIC14319.1 - 5.1e-27 94.8 0.0 7.1e-27 94.4 0.0 1.2 1 0 0 1 1 1 1 Flavin reductase like domain Aminotran_3 PF00202.21 AIC14320.1 - 1.3e-54 185.4 0.0 2.2e-54 184.7 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-III FAM221 PF14753.6 AIC14321.1 - 0.017 14.7 1.8 0.018 14.6 1.8 1.1 1 0 0 1 1 1 0 Protein FAM221A/B ResIII PF04851.15 AIC14324.1 - 2.5e-15 56.9 0.0 6.5e-15 55.5 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 AIC14324.1 - 1e-12 48.4 0.0 2.6e-12 47.1 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 AIC14324.1 - 7.7e-09 35.6 0.2 6e-08 32.6 0.0 2.5 2 2 0 2 2 2 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 AIC14324.1 - 5.3e-06 25.8 0.1 9.2e-06 25.0 0.1 1.3 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF2075 PF09848.9 AIC14324.1 - 0.018 14.3 0.0 0.12 11.5 0.0 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_19 PF13245.6 AIC14324.1 - 0.042 14.2 0.9 1.8 8.9 0.0 3.0 2 1 0 2 2 2 0 AAA domain Ribo_biogen_C PF04034.13 AIC14325.1 - 2.6e-40 137.1 0.0 3.1e-40 136.8 0.0 1.1 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 AIC14325.1 - 0.013 15.3 0.1 0.022 14.5 0.1 1.3 1 0 0 1 1 1 0 Possible Fer4-like domain in RNase L inhibitor, RLI BIRC6 PF12356.8 AIC14326.1 - 0.2 11.1 1.1 0.22 10.9 1.1 1.1 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 DUF3574 PF12098.8 AIC14327.1 - 1e-05 25.3 0.0 1.1e-05 25.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3574) DUF4056 PF13265.6 AIC14328.1 - 0.099 12.0 0.0 0.11 11.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4056) DUF4091 PF13320.6 AIC14329.1 - 0.093 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4091) Methyltr_RsmB-F PF01189.17 AIC14330.1 - 1e-57 195.1 0.0 1.3e-57 194.7 0.0 1.1 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 AIC14330.1 - 1.2e-09 38.5 0.0 3e-09 37.3 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 AIC14330.1 - 0.00024 21.3 0.0 0.00035 20.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 AIC14330.1 - 0.00029 20.7 0.0 0.00038 20.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AIC14330.1 - 0.003 17.4 0.0 0.0051 16.6 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 AIC14330.1 - 0.017 14.8 0.0 0.026 14.2 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical protein 95 Methyltransf_25 PF13649.6 AIC14330.1 - 0.035 14.8 0.0 0.086 13.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain POR PF01558.18 AIC14330.1 - 0.038 14.1 0.0 0.077 13.1 0.0 1.6 1 0 0 1 1 1 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Methyltransf_15 PF09445.10 AIC14330.1 - 0.04 13.5 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Fibrillarin PF01269.17 AIC14330.1 - 0.095 11.8 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Fibrillarin UPF0113 PF03657.13 AIC14331.1 - 4e-23 81.5 0.1 7.5e-23 80.6 0.1 1.5 1 0 0 1 1 1 1 UPF0113 PUA domain UPF0113_N PF17833.1 AIC14331.1 - 3.5e-09 37.1 0.0 5.8e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 UPF0113 Pre-PUA domain PUA PF01472.20 AIC14331.1 - 3.6e-08 33.2 0.2 7.7e-08 32.2 0.2 1.5 1 0 0 1 1 1 1 PUA domain DUF3138 PF11336.8 AIC14331.1 - 0.056 12.1 0.9 0.079 11.6 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) HTH_7 PF02796.15 AIC14332.1 - 0.00064 19.7 0.0 0.001 19.1 0.0 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain of resolvase DUF433 PF04255.14 AIC14332.1 - 0.023 14.5 0.1 0.031 14.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF433) DUF2316 PF10078.9 AIC14332.1 - 0.081 13.2 0.0 0.083 13.1 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) HTH_39 PF14090.6 AIC14332.1 - 0.087 12.6 0.0 0.09 12.5 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Recombinase PF07508.13 AIC14332.1 - 0.093 13.1 0.0 0.1 13.0 0.0 1.2 1 0 0 1 1 1 0 Recombinase HTH_38 PF13936.6 AIC14332.1 - 0.13 12.0 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain UPF0052 PF01933.18 AIC14334.1 - 1.9e-51 175.0 0.1 2.3e-51 174.8 0.1 1.0 1 0 0 1 1 1 1 Uncharacterised protein family UPF0052 DUF374 PF04028.13 AIC14334.1 - 0.11 12.1 0.3 20 4.8 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF374) F-actin_cap_A PF01267.17 AIC14334.1 - 0.25 10.8 0.0 0.4 10.1 0.0 1.2 1 0 0 1 1 1 0 F-actin capping protein alpha subunit CofC PF01983.16 AIC14335.1 - 4.5e-25 88.1 0.0 5.6e-25 87.8 0.0 1.0 1 0 0 1 1 1 1 Guanylyl transferase CofC like NTP_transf_3 PF12804.7 AIC14335.1 - 1.4e-06 28.8 0.7 1.7e-06 28.5 0.7 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain DUF2064 PF09837.9 AIC14335.1 - 0.1 12.4 0.2 0.21 11.4 0.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2064) Pox_RNA_Pol_22 PF05273.13 AIC14336.1 - 0.074 12.8 0.0 0.082 12.7 0.0 1.1 1 0 0 1 1 1 0 Poxvirus RNA polymerase 22 kDa subunit Mrr_cat PF04471.12 AIC14337.1 - 7.8e-05 22.7 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 Restriction endonuclease NERD PF08378.11 AIC14337.1 - 0.02 15.4 0.0 0.028 14.9 0.0 1.3 1 0 0 1 1 1 0 Nuclease-related domain MTES_1575 PF18741.1 AIC14337.1 - 0.091 13.0 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 REase_MTES_1575 DUF2070 PF09843.9 AIC14338.1 - 1.6e-116 389.9 0.2 1.8e-116 389.7 0.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2070) Sec61_beta PF03911.16 AIC14339.1 - 2.1e-14 53.2 1.0 2.5e-14 53.0 1.0 1.1 1 0 0 1 1 1 1 Sec61beta family Auto_anti-p27 PF06677.12 AIC14340.1 - 3.5e-08 33.4 0.6 5.2e-08 32.9 0.6 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DZR PF12773.7 AIC14340.1 - 0.037 14.0 0.3 0.072 13.1 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon TackOD1 PF18551.1 AIC14340.1 - 0.044 13.5 0.2 0.067 12.9 0.2 1.2 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 OrfB_Zn_ribbon PF07282.11 AIC14340.1 - 0.069 13.1 0.6 0.12 12.3 0.6 1.4 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_2 PF13240.6 AIC14340.1 - 0.086 12.6 3.9 4.3 7.2 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Lar_restr_allev PF14354.6 AIC14340.1 - 0.55 10.7 4.8 2.6 8.5 4.8 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.6 AIC14340.1 - 2.1 7.9 6.2 16 5.1 6.2 2.2 1 1 0 1 1 1 0 zinc-ribbon domain SUI1 PF01253.22 AIC14341.1 - 3.2e-20 72.4 0.0 4.8e-20 71.9 0.0 1.3 1 0 0 1 1 1 1 Translation initiation factor SUI1 Img2 PF05046.14 AIC14341.1 - 0.0025 18.1 0.0 0.0031 17.8 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DTW PF03942.15 AIC14341.1 - 0.044 13.5 0.1 0.046 13.4 0.1 1.1 1 0 0 1 1 1 0 DTW domain Paramyxo_C PF01692.18 AIC14341.1 - 0.13 11.6 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 Paramyxovirus non-structural protein C CHASE PF03924.13 AIC14342.1 - 3.6e-60 203.1 0.8 5.7e-60 202.5 0.8 1.3 1 0 0 1 1 1 1 CHASE domain HATPase_c PF02518.26 AIC14342.1 - 1.3e-29 103.0 0.0 3.5e-29 101.6 0.0 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIC14342.1 - 1.1e-12 47.8 0.1 4.8e-12 45.7 0.0 2.1 1 1 1 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 AIC14342.1 - 1.6e-05 24.8 0.1 3.8e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 AIC14342.1 - 0.0003 21.1 0.2 0.00092 19.5 0.2 1.8 1 0 0 1 1 1 1 HAMP domain Bul1_C PF04426.12 AIC14342.1 - 0.055 12.9 0.0 3.4 7.0 0.0 2.3 1 1 1 2 2 2 0 Bul1 C terminus DUF3574 PF12098.8 AIC14342.1 - 0.15 11.9 0.1 0.54 10.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3574) SCAB_CC PF16712.5 AIC14343.1 - 0.016 15.1 0.3 0.016 15.1 0.3 1.4 2 0 0 2 2 2 0 Coiled-coil regions of plant-specific actin-binding protein Anth_synt_I_N PF04715.13 AIC14343.1 - 0.18 12.0 0.0 0.25 11.5 0.0 1.2 1 0 0 1 1 1 0 Anthranilate synthase component I, N terminal region TFIIB PF00382.19 AIC14344.1 - 6.8e-36 122.2 6.8 2e-18 66.2 1.2 2.2 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIC14344.1 - 1.8e-11 43.4 1.4 3.3e-11 42.5 1.4 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Cyclin_C PF02984.19 AIC14344.1 - 0.00019 21.5 0.2 0.23 11.6 0.0 2.3 1 1 0 2 2 2 2 Cyclin, C-terminal domain Sigma70_r4 PF04545.16 AIC14344.1 - 0.00049 19.6 0.0 0.03 13.8 0.0 2.7 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_36 PF13730.6 AIC14344.1 - 0.00096 19.1 1.8 4.2 7.4 0.1 3.3 3 0 0 3 3 3 2 Helix-turn-helix domain Cyclin_N PF00134.23 AIC14344.1 - 0.0034 17.1 0.2 0.03 14.1 0.0 2.0 2 0 0 2 2 2 1 Cyclin, N-terminal domain HTH_AsnC-type PF13404.6 AIC14344.1 - 0.0053 16.6 0.0 0.38 10.6 0.0 2.8 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain zf-CCHC_5 PF14787.6 AIC14344.1 - 0.012 15.3 1.1 0.13 12.0 0.4 2.3 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger zinc_ribbon_2 PF13240.6 AIC14344.1 - 0.012 15.3 2.7 0.69 9.7 0.2 2.4 2 0 0 2 2 2 0 zinc-ribbon domain HTH_Tnp_ISL3 PF13542.6 AIC14344.1 - 0.017 14.5 0.2 1.4 8.4 0.0 3.2 4 0 0 4 4 4 0 Helix-turn-helix domain of transposase family ISL3 HTH_3 PF01381.22 AIC14344.1 - 0.029 14.4 0.0 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix Rrf2 PF02082.20 AIC14344.1 - 0.037 14.4 0.3 20 5.6 0.0 3.1 3 0 0 3 3 3 0 Transcriptional regulator RB_B PF01857.20 AIC14344.1 - 0.039 14.0 0.1 0.076 13.0 0.0 1.5 2 0 0 2 2 1 0 Retinoblastoma-associated protein B domain Auto_anti-p27 PF06677.12 AIC14344.1 - 0.052 13.7 0.9 0.087 13.0 0.9 1.4 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) LacI PF00356.21 AIC14344.1 - 0.069 13.0 4.2 0.65 9.8 0.3 3.3 3 0 0 3 3 3 0 Bacterial regulatory proteins, lacI family Sigma70_r4_2 PF08281.12 AIC14344.1 - 0.08 12.6 0.2 0.43 10.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 Ribosomal_S27e PF01667.17 AIC14344.1 - 0.092 12.5 0.2 0.21 11.3 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S27 Phage_terminase PF10668.9 AIC14344.1 - 0.098 12.7 0.2 4.7 7.3 0.0 2.6 3 0 0 3 3 2 0 Phage terminase small subunit DZR PF12773.7 AIC14344.1 - 0.11 12.5 0.2 0.3 11.2 0.2 1.7 1 0 0 1 1 1 0 Double zinc ribbon MerR PF00376.23 AIC14344.1 - 0.15 11.9 0.1 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 MerR family regulatory protein Ribosomal_L37e PF01907.19 AIC14344.1 - 0.15 12.2 0.1 0.52 10.5 0.1 1.9 1 0 0 1 1 1 0 Ribosomal protein L37e OrfB_Zn_ribbon PF07282.11 AIC14344.1 - 0.17 11.8 1.3 0.43 10.5 1.3 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zf-ribbon_3 PF13248.6 AIC14344.1 - 0.35 10.3 4.9 2.9 7.4 4.9 2.2 1 1 0 1 1 1 0 zinc-ribbon domain Rib_5-P_isom_A PF06026.14 AIC14347.1 - 2.3e-52 177.1 0.0 2.8e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 AIC14347.1 - 3.1e-06 27.2 0.0 0.0098 15.8 0.0 2.2 2 0 0 2 2 2 2 DeoR C terminal sensor domain Sugar-bind PF04198.13 AIC14347.1 - 0.008 15.3 0.0 0.013 14.6 0.0 1.3 1 0 0 1 1 1 1 Putative sugar-binding domain MscL PF01741.18 AIC14348.1 - 2.9e-22 79.2 4.1 3.2e-22 79.1 4.1 1.0 1 0 0 1 1 1 1 Large-conductance mechanosensitive channel, MscL TrpP PF17099.5 AIC14348.1 - 0.0027 17.5 0.9 0.0027 17.5 0.9 1.9 1 1 1 2 2 2 1 Tryptophan transporter TrpP FtsX PF02687.21 AIC14348.1 - 0.0032 17.9 3.0 0.0043 17.5 3.0 1.2 1 0 0 1 1 1 1 FtsX-like permease family Reticulon PF02453.17 AIC14348.1 - 0.016 15.1 0.8 0.02 14.8 0.8 1.1 1 0 0 1 1 1 0 Reticulon DUF1449 PF07290.11 AIC14348.1 - 0.098 12.3 2.4 0.068 12.8 1.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1449) NPCC PF08058.11 AIC14348.1 - 0.13 12.4 0.4 0.15 12.1 0.4 1.1 1 0 0 1 1 1 0 Nuclear pore complex component Amidohydro_1 PF01979.20 AIC14349.1 - 7.3e-22 78.1 0.1 1.2e-20 74.1 0.1 2.3 1 1 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 AIC14349.1 - 4.9e-14 52.7 0.8 7.2e-07 29.0 0.1 3.0 1 1 1 2 2 2 2 Amidohydrolase family Urease_alpha PF00449.20 AIC14349.1 - 0.00052 20.3 0.1 0.0014 19.0 0.1 1.7 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain DUF1574 PF07611.11 AIC14353.1 - 0.056 12.8 0.2 0.063 12.6 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1574) DUF3291 PF11695.8 AIC14355.1 - 2.9e-06 27.0 1.3 4.7e-06 26.3 1.3 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3291) DUF4188 PF13826.6 AIC14355.1 - 0.00038 20.8 0.2 0.00051 20.4 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4188) Polysacc_deac_1 PF01522.21 AIC14356.1 - 8e-12 45.1 0.0 1.4e-11 44.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIC14356.1 - 4.3e-08 33.1 0.0 6.1e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 AIC14356.1 - 8.4e-06 25.2 0.0 1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 PAS_8 PF13188.7 AIC14356.1 - 0.0085 16.1 0.0 0.7 10.0 0.0 3.0 2 1 1 3 3 3 1 PAS domain HTH_45 PF14947.6 AIC14357.1 - 4.2e-17 61.9 0.0 5.2e-17 61.6 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC14357.1 - 0.086 12.6 0.0 0.094 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) DUF3102 PF11300.8 AIC14357.1 - 0.088 13.0 0.1 0.088 13.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) TIG PF01833.24 AIC14358.1 - 1.4e-05 25.1 17.7 0.00041 20.4 2.5 3.1 3 1 0 3 3 3 2 IPT/TIG domain MG2 PF01835.19 AIC14358.1 - 0.0012 19.2 0.2 0.72 10.4 0.0 2.7 2 0 0 2 2 2 2 MG2 domain NPCBM_assoc PF10633.9 AIC14358.1 - 0.025 14.8 10.4 0.094 13.0 0.2 4.4 3 1 1 4 4 4 0 NPCBM-associated, NEW3 domain of alpha-galactosidase CarboxypepD_reg PF13620.6 AIC14358.1 - 0.49 10.7 18.2 0.061 13.6 1.7 3.5 2 1 2 4 4 4 0 Carboxypeptidase regulatory-like domain Cadherin-like PF12733.7 AIC14358.1 - 0.51 10.9 5.9 10 6.7 0.2 3.5 2 1 2 4 4 4 0 Cadherin-like beta sandwich domain DUF4112 PF13430.6 AIC14359.1 - 0.0073 16.6 0.5 2.3 8.5 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4112) Dicistro_VP4 PF11492.8 AIC14359.1 - 0.074 13.0 0.3 1.2 9.1 0.0 2.3 1 1 1 2 2 2 0 Cricket paralysis virus, VP4 TMEM65 PF10507.9 AIC14360.1 - 0.059 13.3 0.0 0.063 13.2 0.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 65 Patatin PF01734.22 AIC14361.1 - 5.7e-15 56.0 0.0 2.9e-14 53.7 0.0 2.0 1 1 0 1 1 1 1 Patatin-like phospholipase Cupin_2 PF07883.11 AIC14362.1 - 1.9e-07 30.7 0.1 5.6e-07 29.2 0.0 1.7 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 AIC14362.1 - 2.8e-06 26.9 0.0 8.5e-06 25.4 0.0 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF861) AraC_binding_2 PF14525.6 AIC14362.1 - 1.6e-05 24.7 0.0 1.9e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 AraC-binding-like domain AraC_binding PF02311.19 AIC14362.1 - 0.0036 17.2 0.0 0.006 16.5 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_6 PF12852.7 AIC14362.1 - 0.064 13.0 0.0 0.074 12.8 0.0 1.1 1 0 0 1 1 1 0 Cupin Cupin_1 PF00190.22 AIC14362.1 - 0.12 11.9 0.0 1.1 8.9 0.0 1.9 2 0 0 2 2 2 0 Cupin Clathrin_propel PF01394.20 AIC14362.1 - 0.17 12.3 0.0 3.9 7.9 0.0 2.4 2 0 0 2 2 2 0 Clathrin propeller repeat Ccdc124 PF06244.12 AIC14363.1 - 0.014 15.9 1.1 0.026 15.1 1.1 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 124 /Oxs1 DUF5320 PF17253.2 AIC14363.1 - 0.082 14.0 1.3 0.58 11.3 1.3 2.3 1 1 0 1 1 1 0 Family of unknown function (DUF5320) CCDC-167 PF15188.6 AIC14363.1 - 0.2 12.0 2.1 6 7.3 0.4 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 zf-C2H2_2 PF12756.7 AIC14364.1 - 5.2e-06 26.7 0.4 6.5e-06 26.4 0.4 1.2 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2HE PF16278.5 AIC14364.1 - 0.024 15.1 0.6 0.038 14.4 0.0 1.6 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_jaz PF12171.8 AIC14364.1 - 0.048 14.0 0.5 0.089 13.1 0.5 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 AIC14364.1 - 0.054 13.9 0.2 0.092 13.2 0.2 1.4 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 AIC14364.1 - 0.065 13.7 0.1 0.11 13.0 0.1 1.4 1 0 0 1 1 1 0 Zinc finger, C2H2 type CTU2 PF10288.9 AIC14364.1 - 0.066 13.5 1.5 0.078 13.2 1.5 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 zf-C2H2_4 PF13894.6 AIC14364.1 - 0.15 13.0 0.1 0.15 13.0 0.1 1.7 2 0 0 2 2 2 0 C2H2-type zinc finger BT1 PF03092.16 AIC14364.1 - 0.31 9.2 0.0 0.33 9.1 0.0 1.0 1 0 0 1 1 1 0 BT1 family MHC_I PF00129.18 AIC14365.1 - 0.066 12.8 0.3 0.077 12.6 0.3 1.0 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Malic_M PF03949.15 AIC14366.1 - 2.7e-25 89.1 0.9 5.2e-24 84.9 0.9 2.4 1 1 0 1 1 1 1 Malic enzyme, NAD binding domain malic PF00390.19 AIC14366.1 - 6.4e-21 75.0 3.5 3.5e-18 66.0 0.2 3.1 2 1 1 3 3 3 2 Malic enzyme, N-terminal domain AdoHcyase_NAD PF00670.21 AIC14366.1 - 0.00042 20.4 1.6 0.029 14.4 0.0 3.0 3 0 0 3 3 3 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ELFV_dehydrog PF00208.21 AIC14366.1 - 0.0014 18.4 2.2 0.014 15.2 2.1 2.4 2 1 1 3 3 3 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase FAD_binding_3 PF01494.19 AIC14366.1 - 0.0046 16.2 0.1 0.0069 15.7 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Shikimate_DH PF01488.20 AIC14366.1 - 0.0047 17.0 0.1 0.033 14.2 0.1 2.3 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 AIC14366.1 - 0.045 14.0 0.7 0.4 11.0 0.1 2.5 2 0 0 2 2 2 0 TrkA-N domain ThiF PF00899.21 AIC14366.1 - 0.074 12.4 0.9 0.15 11.4 0.9 1.5 1 0 0 1 1 1 0 ThiF family 2-Hacid_dh_C PF02826.19 AIC14366.1 - 0.12 11.7 0.6 0.29 10.5 0.2 1.9 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain zf-C2H2 PF00096.26 AIC14367.1 - 2.2e-05 24.6 10.1 0.0014 18.9 0.5 3.2 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIC14367.1 - 0.0002 21.2 0.6 0.0002 21.2 0.6 3.0 4 0 0 4 4 3 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AIC14367.1 - 0.0003 21.4 15.6 0.00091 19.9 0.1 3.0 4 0 0 4 4 2 2 C2H2-type zinc finger zinc_ribbon_5 PF13719.6 AIC14367.1 - 0.00031 20.4 0.4 0.23 11.2 0.1 2.1 2 0 0 2 2 2 2 zinc-ribbon domain zf-C2H2_3rep PF18868.1 AIC14367.1 - 0.013 16.2 6.3 1.2 9.8 4.5 2.0 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zinc_ribbon_4 PF13717.6 AIC14367.1 - 0.023 14.6 3.2 0.33 10.9 3.2 2.1 1 1 1 2 2 2 0 zinc-ribbon domain LIM PF00412.22 AIC14367.1 - 0.023 14.9 5.6 0.032 14.5 5.2 1.5 1 1 0 1 1 1 0 LIM domain Lar_restr_allev PF14354.6 AIC14367.1 - 0.026 14.9 3.1 0.34 11.3 3.2 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar zinc_ribbon_15 PF17032.5 AIC14367.1 - 0.027 15.2 1.9 0.031 15.0 1.4 1.4 1 1 0 1 1 1 0 zinc-ribbon family zf-trcl PF13451.6 AIC14367.1 - 0.027 14.3 3.5 0.26 11.2 0.1 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf_C2H2_ZHX PF18387.1 AIC14367.1 - 0.048 13.3 0.6 0.048 13.3 0.6 2.5 1 1 2 3 3 2 0 Zinc-fingers and homeoboxes C2H2 finger domain RNA_POL_M_15KD PF02150.16 AIC14367.1 - 0.062 13.2 0.8 1 9.3 0.3 2.2 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit FOXP-CC PF16159.5 AIC14367.1 - 0.076 13.7 8.5 0.41 11.3 0.5 2.1 1 1 1 2 2 2 0 FOXP coiled-coil domain HypA PF01155.19 AIC14367.1 - 0.13 12.3 2.2 0.63 10.1 1.9 1.9 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 AIC14367.1 - 0.14 12.3 9.2 1.3 9.2 7.3 2.3 1 1 1 2 2 2 0 Zinc ribbon domain DUF629 PF04780.12 AIC14367.1 - 0.15 10.6 14.0 0.38 9.2 6.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) DNA_RNApol_7kD PF03604.13 AIC14367.1 - 0.17 11.6 2.1 0.36 10.6 0.2 2.1 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf-LYAR PF08790.11 AIC14367.1 - 0.19 11.6 6.8 3.3 7.7 0.8 2.8 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-HYPF PF07503.12 AIC14367.1 - 0.23 11.3 6.1 0.76 9.6 1.6 2.3 2 0 0 2 2 2 0 HypF finger Elf1 PF05129.13 AIC14367.1 - 0.25 11.4 4.3 0.49 10.5 4.3 1.8 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like zinc_ribbon_9 PF14369.6 AIC14367.1 - 0.39 11.0 3.8 0.42 10.9 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon Actin_micro PF17003.5 AIC14367.1 - 0.9 8.6 12.9 8.2 5.5 12.9 1.9 1 1 0 1 1 1 0 Putative actin-like family HNH PF01844.23 AIC14367.1 - 0.92 9.7 14.8 0.28 11.4 5.0 2.4 2 0 0 2 2 2 0 HNH endonuclease zf-C2HE PF16278.5 AIC14367.1 - 0.93 10.0 8.0 1.5 9.3 0.3 2.8 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger DUF2291 PF10054.9 AIC14368.1 - 0.02 14.6 1.0 3.9 7.2 0.1 2.2 1 1 1 2 2 2 0 Predicted periplasmic lipoprotein (DUF2291) Helicase_C_3 PF13625.6 AIC14368.1 - 0.081 13.1 1.6 0.15 12.2 0.4 2.1 2 1 1 3 3 3 0 Helicase conserved C-terminal domain SinI PF08671.10 AIC14368.1 - 0.17 11.7 0.1 0.43 10.4 0.0 1.8 2 0 0 2 2 2 0 Anti-repressor SinI HTH_45 PF14947.6 AIC14369.1 - 2.9e-10 40.0 0.1 3.5e-10 39.7 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix RQC PF09382.10 AIC14369.1 - 0.0025 17.6 0.0 0.0031 17.3 0.0 1.3 1 1 0 1 1 1 1 RQC domain HTH_27 PF13463.6 AIC14369.1 - 0.0094 16.4 0.1 0.012 16.1 0.1 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF4364 PF14277.6 AIC14369.1 - 0.019 14.7 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) FAD_binding_4 PF01565.23 AIC14369.1 - 0.031 14.0 0.0 0.039 13.7 0.0 1.1 1 0 0 1 1 1 0 FAD binding domain HTH_24 PF13412.6 AIC14369.1 - 0.13 11.8 0.1 0.22 11.1 0.1 1.5 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding FaeA PF04703.12 AIC14369.1 - 0.14 12.6 0.0 0.22 11.9 0.0 1.2 1 0 0 1 1 1 0 FaeA-like protein DUF2207 PF09972.9 AIC14370.1 - 0.32 9.7 0.3 0.33 9.7 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Peptidase_M50B PF13398.6 AIC14372.1 - 0.02 14.5 7.1 0.028 14.1 7.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Zip PF02535.22 AIC14373.1 - 0.00072 18.9 12.7 0.00072 18.9 12.7 2.4 2 1 0 2 2 2 2 ZIP Zinc transporter AzlD PF05437.12 AIC14373.1 - 4.1 7.6 15.7 0.043 14.0 2.1 3.1 2 2 1 3 3 3 0 Branched-chain amino acid transport protein (AzlD) dCMP_cyt_deam_1 PF00383.23 AIC14374.1 - 5.6e-07 29.4 0.1 1.3e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AIC14374.1 - 3.6e-05 23.5 0.0 6.7e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 AIC14374.1 - 0.087 12.9 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 OTT_1508_deam PF14441.6 AIC14374.1 - 0.099 12.7 0.0 0.31 11.1 0.0 1.8 2 0 0 2 2 2 0 OTT_1508-like deaminase Oxidored_q3 PF00499.20 AIC14375.1 - 0.0087 15.8 0.7 0.013 15.2 0.7 1.2 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 dCache_1 PF02743.18 AIC14376.1 - 2.9e-18 66.6 0.0 3.4e-18 66.3 0.0 1.1 1 0 0 1 1 1 1 Cache domain sCache_3_3 PF17202.4 AIC14376.1 - 0.034 14.6 0.1 0.25 11.8 0.0 2.3 2 1 0 2 2 2 0 Single cache domain 3 dCache_1 PF02743.18 AIC14378.1 - 8.9e-17 61.7 0.1 1.1e-16 61.4 0.1 1.1 1 0 0 1 1 1 1 Cache domain dCache_3 PF14827.6 AIC14378.1 - 0.01 15.5 0.1 0.088 12.4 0.0 2.1 1 1 1 2 2 2 0 Double sensory domain of two-component sensor kinase Bep_C_terminal PF17841.1 AIC14378.1 - 0.048 13.9 0.0 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) Acetyltransf_18 PF18014.1 AIC14379.1 - 1.2e-29 102.7 0.0 2e-29 101.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AIC14379.1 - 6.7e-11 42.5 0.3 1.4e-09 38.2 0.1 2.6 2 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIC14379.1 - 2.6e-06 27.8 0.3 5.3e-06 26.8 0.3 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIC14379.1 - 2.8e-05 24.1 0.0 6.5e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIC14379.1 - 0.00069 19.5 0.1 0.0022 17.9 0.1 1.8 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_3 PF13302.7 AIC14379.1 - 0.024 15.3 0.0 0.23 12.1 0.1 2.1 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIC14379.1 - 0.025 14.7 0.0 0.042 13.9 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AIC14379.1 - 0.12 12.5 0.0 0.33 11.1 0.0 1.7 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase Pribosyltran PF00156.27 AIC14380.1 - 8.8e-13 48.1 0.2 2.6e-12 46.5 0.2 1.7 1 1 0 1 1 1 1 Phosphoribosyl transferase domain TOBE_3 PF12857.7 AIC14380.1 - 0.024 14.5 0.1 0.038 13.9 0.1 1.3 1 0 0 1 1 1 0 TOBE-like domain DUF1221 PF06760.11 AIC14380.1 - 0.14 11.6 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1221) ATPgrasp_N PF18130.1 AIC14380.1 - 0.16 12.5 0.1 1.6 9.3 0.0 2.0 1 1 1 2 2 2 0 ATP-grasp N-terminal domain zinc_ribbon_4 PF13717.6 AIC14381.1 - 0.0013 18.7 3.5 0.0029 17.5 3.5 1.6 1 1 0 1 1 1 1 zinc-ribbon domain Zn_Tnp_IS1 PF03811.13 AIC14381.1 - 0.0013 18.4 0.4 0.002 17.8 0.4 1.3 1 1 0 1 1 1 1 InsA N-terminal domain UPF0515 PF15135.6 AIC14381.1 - 0.0018 17.7 1.4 0.0018 17.7 1.4 1.0 1 0 0 1 1 1 1 Uncharacterised protein UPF0515 Zn_Tnp_IS1595 PF12760.7 AIC14381.1 - 0.0025 17.7 1.7 0.0027 17.6 1.7 1.1 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rubredoxin_2 PF18073.1 AIC14381.1 - 0.017 14.8 5.7 0.054 13.2 0.2 2.1 2 0 0 2 2 2 0 Rubredoxin metal binding domain OrfB_Zn_ribbon PF07282.11 AIC14381.1 - 0.08 12.9 0.9 0.1 12.5 0.9 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_5 PF13719.6 AIC14381.1 - 1.3 8.8 7.1 7.8 6.4 7.1 1.9 1 1 0 1 1 1 0 zinc-ribbon domain TFIIS_C PF01096.18 AIC14381.1 - 2.1 8.3 8.1 5.3 7.0 0.6 2.1 1 1 2 3 3 3 0 Transcription factor S-II (TFIIS) PIN_10 PF18478.1 AIC14382.1 - 0.057 13.6 0.0 7.2 6.9 0.0 2.1 1 1 1 2 2 2 0 PIN like domain MIase PF02426.16 AIC14384.1 - 6.4e-18 64.7 0.1 2e-17 63.1 0.0 1.7 1 1 1 2 2 2 1 Muconolactone delta-isomerase Ribosom_S30AE_C PF16321.5 AIC14384.1 - 0.06 13.0 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus Hemerythrin PF01814.23 AIC14385.1 - 6e-15 56.0 0.4 1.1e-14 55.1 0.1 1.6 2 0 0 2 2 2 1 Hemerythrin HHE cation binding domain GFA PF04828.14 AIC14386.1 - 0.012 15.9 0.4 4.3 7.7 0.1 2.1 1 1 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Tnp_zf-ribbon_2 PF13842.6 AIC14386.1 - 0.044 14.6 0.2 1.2 10.0 0.0 2.1 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Arc_trans_TRASH PF08394.10 AIC14386.1 - 0.097 13.0 1.6 1.3 9.4 0.0 2.8 3 0 0 3 3 3 0 Archaeal TRASH domain Yippee-Mis18 PF03226.14 AIC14386.1 - 0.12 12.6 0.0 14 6.0 0.0 2.2 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PDZ_2 PF13180.6 AIC14387.1 - 4.1e-14 52.7 0.3 1.6e-11 44.3 0.3 2.2 1 1 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 AIC14387.1 - 5.7e-13 48.5 4.0 3.1e-07 30.2 1.1 2.2 1 1 1 2 2 2 2 PDZ domain PDZ PF00595.24 AIC14387.1 - 3.4e-10 40.1 0.3 2.9e-05 24.3 0.1 2.2 2 0 0 2 2 2 2 PDZ domain Tricorn_PDZ PF14685.6 AIC14387.1 - 0.006 16.5 0.3 0.3 11.1 0.0 2.3 1 1 1 2 2 2 1 Tricorn protease PDZ domain Aminotran_3 PF00202.21 AIC14388.1 - 6e-85 285.3 0.0 7.9e-85 285.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III DUF4192 PF13830.6 AIC14388.1 - 0.044 13.8 0.0 0.074 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) PrpR_N PF06506.11 AIC14388.1 - 0.16 11.6 0.0 0.39 10.3 0.0 1.6 1 0 0 1 1 1 0 Propionate catabolism activator Acyl-CoA_dh_1 PF00441.24 AIC14389.1 - 5.9e-34 117.5 3.5 1.1e-32 113.3 3.5 2.4 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 AIC14389.1 - 3.3e-22 78.5 0.1 5.5e-22 77.8 0.1 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_N PF02771.16 AIC14389.1 - 1.2e-19 71.0 0.5 4e-19 69.3 0.0 2.1 2 1 1 3 3 3 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 AIC14389.1 - 4.3e-12 46.4 9.0 2.9e-11 43.8 9.0 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HATPase_c_3 PF13589.6 AIC14389.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MaoC_dehydratas PF01575.19 AIC14390.1 - 0.00016 21.2 0.0 0.002 17.7 0.0 2.0 1 1 0 1 1 1 1 MaoC like domain MaoC_dehydrat_N PF13452.6 AIC14390.1 - 0.00046 20.3 0.0 0.00067 19.8 0.0 1.2 1 1 0 1 1 1 1 N-terminal half of MaoC dehydratase LpxC PF03331.13 AIC14390.1 - 0.15 11.6 0.0 0.23 10.9 0.0 1.3 1 0 0 1 1 1 0 UDP-3-O-acyl N-acetylglycosamine deacetylase DUF4769 PF15992.5 AIC14391.1 - 2.1 8.0 5.2 2.2 8.0 5.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) DUF4795 PF16043.5 AIC14392.1 - 0.022 14.3 0.1 0.027 14.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF2922 PF11148.8 AIC14392.1 - 0.35 10.6 2.0 13 5.6 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2922) DZR PF12773.7 AIC14397.1 - 0.001 19.0 1.2 0.0014 18.6 1.2 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF4870 PF09685.10 AIC14397.1 - 0.021 14.9 0.7 0.029 14.5 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) DUF1272 PF06906.11 AIC14397.1 - 0.028 14.5 0.9 0.04 14.0 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zinc_ribbon_2 PF13240.6 AIC14397.1 - 0.078 12.7 6.3 1 9.2 6.0 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIC14397.1 - 0.1 12.8 3.6 0.28 11.4 3.6 1.7 1 1 0 1 1 1 0 Zinc ribbon domain DUF2207 PF09972.9 AIC14397.1 - 0.17 10.6 0.7 0.21 10.3 0.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PolC_DP2 PF03833.13 AIC14397.1 - 0.25 9.2 0.3 0.29 9.0 0.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zinc_ribbon_10 PF10058.9 AIC14397.1 - 0.26 11.0 3.5 0.85 9.4 0.2 2.2 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-RRN7 PF11781.8 AIC14397.1 - 0.26 11.0 5.0 1.2 8.9 1.1 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 HypA PF01155.19 AIC14397.1 - 0.27 11.3 1.7 0.41 10.7 1.7 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AIC14397.1 - 0.39 10.2 6.6 0.18 11.3 1.3 2.1 1 1 0 1 1 1 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIC14397.1 - 0.55 9.8 5.5 2.6 7.6 0.9 2.2 1 1 1 2 2 2 0 TFIIB zinc-binding DUF1610 PF07754.11 AIC14397.1 - 5.5 7.0 8.0 2.2 8.3 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) DUF2614 PF11023.8 AIC14397.1 - 7 6.8 6.6 1.7 8.8 0.2 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain C1_4 PF07975.12 AIC14398.1 - 0.0066 16.7 0.5 0.0069 16.6 0.5 1.1 1 0 0 1 1 1 1 TFIIH C1-like domain IMS PF00817.20 AIC14399.1 - 5.7e-43 146.5 0.1 9.5e-43 145.8 0.1 1.4 1 0 0 1 1 1 1 impB/mucB/samB family DUF72 PF01904.18 AIC14399.1 - 5.8e-21 75.6 0.0 1.2e-20 74.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function DUF72 IMS_C PF11799.8 AIC14399.1 - 8.3e-11 42.6 0.1 1.4e-10 41.9 0.1 1.3 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 AIC14399.1 - 2.9e-07 30.4 0.1 5.9e-07 29.4 0.1 1.6 1 0 0 1 1 1 1 IMS family HHH motif HHH_5 PF14520.6 AIC14399.1 - 0.00014 22.3 0.3 0.00093 19.8 0.1 2.2 2 0 0 2 2 2 1 Helix-hairpin-helix domain Cdd1 PF11731.8 AIC14399.1 - 0.017 15.4 0.0 0.041 14.1 0.0 1.7 1 0 0 1 1 1 0 Pathogenicity locus DUF4332 PF14229.6 AIC14399.1 - 0.066 13.5 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) Pro_isomerase PF00160.21 AIC14400.1 - 5.6e-53 179.4 0.1 6.2e-53 179.3 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD BKACE PF05853.12 AIC14400.1 - 0.046 13.0 0.0 3.8 6.7 0.0 2.1 2 0 0 2 2 2 0 beta-keto acid cleavage enzyme TetR_N PF00440.23 AIC14401.1 - 2.3e-18 65.7 0.4 6.7e-18 64.2 0.0 2.0 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 AIC14401.1 - 2.2e-11 44.0 0.0 3.7e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal TetR_C_31 PF17940.1 AIC14401.1 - 0.00028 21.1 0.1 0.00061 20.0 0.1 1.6 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_11 PF16859.5 AIC14401.1 - 0.0044 17.3 0.1 0.009 16.3 0.1 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 AIC14401.1 - 0.12 12.6 0.1 0.58 10.3 0.0 2.1 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase DM13 PF10517.9 AIC14402.1 - 3.1e-21 75.9 0.0 5.4e-21 75.1 0.0 1.4 1 0 0 1 1 1 1 Electron transfer DM13 RVT_3 PF13456.6 AIC14403.1 - 2.7e-20 72.4 0.0 3.1e-20 72.2 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase-like RNase_H PF00075.24 AIC14403.1 - 2.2e-10 40.9 0.0 4.2e-10 40.0 0.0 1.4 1 1 0 1 1 1 1 RNase H SurA_N_3 PF13624.6 AIC14404.1 - 0.015 15.1 0.2 0.016 15.0 0.2 1.0 1 0 0 1 1 1 0 SurA N-terminal domain Cep57_MT_bd PF06657.13 AIC14405.1 - 0.0041 17.5 2.9 0.0051 17.2 2.9 1.1 1 0 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 DivIC PF04977.15 AIC14405.1 - 0.0065 16.2 0.3 0.0071 16.1 0.3 1.1 1 0 0 1 1 1 1 Septum formation initiator FAM76 PF16046.5 AIC14405.1 - 0.038 13.3 1.0 0.039 13.3 1.0 1.1 1 0 0 1 1 1 0 FAM76 protein CdiI_2 PF18593.1 AIC14405.1 - 0.039 14.6 0.1 0.045 14.4 0.1 1.1 1 0 0 1 1 1 0 CdiI immunity protein DUF4140 PF13600.6 AIC14405.1 - 0.046 14.2 0.1 0.049 14.1 0.1 1.0 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) TPD52 PF04201.15 AIC14405.1 - 0.054 13.1 0.6 0.048 13.3 0.6 1.0 1 0 0 1 1 1 0 Tumour protein D52 family 60KD_IMP PF02096.20 AIC14405.1 - 0.18 11.7 0.2 0.18 11.7 0.2 1.0 1 0 0 1 1 1 0 60Kd inner membrane protein DUF465 PF04325.13 AIC14405.1 - 0.67 10.0 10.1 1.8 8.6 10.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF465) SIMPL PF04402.14 AIC14406.1 - 3.1e-44 151.8 4.2 4e-44 151.5 4.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) Beta_propel PF09826.9 AIC14407.1 - 1.5e-153 512.4 9.7 1.7e-153 512.2 9.7 1.0 1 0 0 1 1 1 1 Beta propeller domain Herpes_capsid PF06112.11 AIC14408.1 - 0.16 12.0 10.7 0.25 11.4 10.7 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CorA PF01544.18 AIC14409.1 - 0.0085 15.4 0.3 0.017 14.5 0.3 1.4 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein KxDL PF10241.9 AIC14409.1 - 0.012 15.9 3.6 0.022 15.0 3.6 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein BLOC1_2 PF10046.9 AIC14409.1 - 0.025 14.9 3.7 0.05 13.9 3.7 1.5 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tcp11 PF05794.13 AIC14409.1 - 0.027 13.6 4.8 0.031 13.4 4.8 1.0 1 0 0 1 1 1 0 T-complex protein 11 bZIP_1 PF00170.21 AIC14409.1 - 0.062 13.4 0.8 0.062 13.4 0.8 2.8 2 1 1 3 3 2 0 bZIP transcription factor DUF2951 PF11166.8 AIC14409.1 - 0.076 13.2 1.6 0.1 12.8 1.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) Exonuc_VII_L PF02601.15 AIC14409.1 - 0.15 11.6 8.5 0.18 11.4 8.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit FlxA PF14282.6 AIC14409.1 - 0.17 11.9 12.9 0.017 15.1 8.0 1.8 1 1 1 2 2 2 0 FlxA-like protein eIF3_N PF09440.10 AIC14409.1 - 0.21 12.0 6.2 0.13 12.7 3.6 1.8 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain MCU PF04678.13 AIC14409.1 - 0.21 11.6 5.2 0.25 11.4 5.2 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF3138 PF11336.8 AIC14409.1 - 0.26 9.9 4.2 0.34 9.5 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) DASH_Duo1 PF08651.10 AIC14409.1 - 0.28 11.0 3.5 0.1 12.4 1.0 1.6 2 0 0 2 2 1 0 DASH complex subunit Duo1 Spc7 PF08317.11 AIC14409.1 - 0.33 9.8 8.1 0.4 9.5 8.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 AIC14409.1 - 0.64 10.5 7.0 1.1 9.8 6.9 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF1690 PF07956.11 AIC14409.1 - 0.71 10.3 8.6 0.97 9.8 8.6 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) TMPIT PF07851.13 AIC14409.1 - 1.3 8.2 4.6 1.7 7.8 4.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein Uso1_p115_C PF04871.13 AIC14409.1 - 2.3 8.6 12.6 0.96 9.8 10.1 1.7 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Copper-bind PF00127.20 AIC14410.1 - 2.5e-06 27.9 0.0 0.033 14.6 0.0 2.4 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC14410.1 - 0.0093 16.1 0.3 0.15 12.2 0.0 2.5 2 1 0 2 2 2 1 Cupredoxin-like domain DUF1451 PF07295.11 AIC14411.1 - 0.0046 17.0 0.5 0.0047 17.0 0.5 1.2 1 0 0 1 1 1 1 Zinc-ribbon containing domain A2L_zn_ribbon PF08792.10 AIC14411.1 - 0.027 14.2 2.6 0.57 10.0 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain TF_Zn_Ribbon PF08271.12 AIC14411.1 - 0.041 13.4 0.4 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 TFIIB zinc-binding Prim_Zn_Ribbon PF08273.12 AIC14411.1 - 0.11 12.7 2.1 0.2 11.9 2.1 1.5 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase zf_UBZ PF18439.1 AIC14411.1 - 0.16 11.6 1.4 0.91 9.2 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIC14412.1 - 0.0069 16.4 9.2 0.0074 16.3 7.3 1.8 1 1 0 1 1 1 1 Double zinc ribbon Ribosomal_L32p PF01783.23 AIC14412.1 - 0.027 14.7 1.8 0.027 14.7 1.8 2.1 1 1 1 2 2 2 0 Ribosomal L32p protein family PolC_DP2 PF03833.13 AIC14412.1 - 0.14 10.0 2.9 0.15 9.9 2.9 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 zf-Sec23_Sec24 PF04810.15 AIC14412.1 - 1 9.5 6.8 0.45 10.6 4.2 2.0 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger DUF4379 PF14311.6 AIC14412.1 - 2.1 8.8 8.0 4.6 7.7 8.0 1.7 1 1 0 1 1 1 0 Probable Zinc-ribbon domain HypA PF01155.19 AIC14414.1 - 0.026 14.6 0.3 0.029 14.4 0.3 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Jas PF16135.5 AIC14414.1 - 0.026 14.7 0.8 0.26 11.5 0.8 2.0 1 1 0 1 1 1 0 TPL-binding domain in jasmonate signalling zinc_ribbon_4 PF13717.6 AIC14414.1 - 0.044 13.7 0.3 0.42 10.6 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain FlgD_ig PF13860.6 AIC14415.1 - 6.1e-12 45.2 1.9 6.1e-12 45.2 1.9 2.4 2 1 1 3 3 3 1 FlgD Ig-like domain CHU_C PF13585.6 AIC14415.1 - 0.0031 17.5 0.0 0.0062 16.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of CHU protein family N6_N4_Mtase PF01555.18 AIC14416.1 - 4.1e-41 141.2 0.0 6e-41 140.7 0.0 1.2 1 0 0 1 1 1 1 DNA methylase Methyltransf_25 PF13649.6 AIC14416.1 - 2.6e-05 24.8 0.0 0.002 18.8 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC14416.1 - 0.0001 22.1 0.0 0.001 18.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14416.1 - 0.00035 21.2 0.0 0.31 11.7 0.0 2.5 2 0 0 2 2 2 2 Methyltransferase domain UPF0020 PF01170.18 AIC14416.1 - 0.0004 20.1 0.1 0.77 9.4 0.1 2.8 2 1 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_15 PF09445.10 AIC14416.1 - 0.073 12.6 0.1 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 RNA cap guanine-N2 methyltransferase Methyltransf_12 PF08242.12 AIC14416.1 - 0.12 13.1 0.0 2.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain YqgC PF17430.2 AIC14417.1 - 0.02 14.9 0.0 0.028 14.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized YqgC-like DUF5530 PF17670.1 AIC14417.1 - 0.14 11.9 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5530) AmoC PF04896.12 AIC14419.1 - 5.7e-14 52.0 7.3 6.7e-14 51.7 7.3 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C YjeF_N PF03853.15 AIC14420.1 - 1.9e-45 154.8 0.1 2.5e-45 154.4 0.1 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Lactamase_B PF00753.27 AIC14421.1 - 9.1e-21 74.8 2.8 8e-20 71.7 2.8 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIC14421.1 - 0.0001 21.9 0.1 0.00029 20.4 0.1 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_5 PF14597.6 AIC14421.1 - 0.0019 17.7 0.0 0.0024 17.4 0.0 1.1 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily DBI_PRT PF02277.17 AIC14422.1 - 3.8e-13 49.4 3.5 5.4e-13 48.9 3.5 1.2 1 0 0 1 1 1 1 Phosphoribosyltransferase Pur_DNA_glyco PF02245.16 AIC14424.1 - 3e-63 212.4 0.0 3.4e-63 212.2 0.0 1.0 1 0 0 1 1 1 1 Methylpurine-DNA glycosylase (MPG) UDG PF03167.19 AIC14425.1 - 6.8e-47 159.3 0.0 8.4e-47 159.0 0.0 1.1 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily Gram_pos_anchor PF00746.21 AIC14426.1 - 0.0011 18.8 4.3 0.039 13.9 0.1 2.1 2 0 0 2 2 2 2 LPXTG cell wall anchor motif Phage_holin_3_6 PF07332.11 AIC14426.1 - 0.057 13.5 1.2 0.089 12.8 1.2 1.4 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF202 PF02656.15 AIC14426.1 - 0.069 13.6 1.1 0.11 13.0 1.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF202) B12D PF06522.11 AIC14426.1 - 0.18 11.6 1.6 0.66 9.8 0.0 2.1 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit Transglut_core2 PF13369.6 AIC14427.1 - 8.9e-41 139.0 0.0 1.6e-40 138.2 0.0 1.4 1 0 0 1 1 1 1 Transglutaminase-like superfamily TPR_9 PF13371.6 AIC14427.1 - 4.4e-12 46.0 0.5 7.8e-12 45.2 0.5 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 AIC14427.1 - 0.00082 19.8 0.9 0.0018 18.7 0.9 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 AIC14427.1 - 0.0028 17.4 0.0 0.0075 16.1 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 AIC14427.1 - 0.0043 17.7 0.3 0.012 16.3 0.3 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 AIC14427.1 - 0.0052 16.8 0.0 0.015 15.4 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 AIC14427.1 - 0.012 16.3 0.2 0.034 15.0 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 AIC14427.1 - 0.019 15.2 0.0 0.094 13.0 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 AIC14427.1 - 0.038 14.4 0.1 1.7 9.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat HHH_5 PF14520.6 AIC14427.1 - 0.1 13.2 0.1 0.25 12.0 0.1 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain Ammonium_transp PF00909.21 AIC14428.1 - 1.9e-118 395.6 37.5 2.7e-118 395.1 37.5 1.2 1 0 0 1 1 1 1 Ammonium Transporter Family Na_H_Exchanger PF00999.21 AIC14430.1 - 6e-60 203.0 58.7 7.7e-60 202.7 58.7 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Frankia_peptide PF14407.6 AIC14431.1 - 0.0018 18.2 0.0 0.0025 17.7 0.0 1.3 1 0 0 1 1 1 1 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. LigA PF07746.11 AIC14431.1 - 0.16 12.1 0.0 0.21 11.8 0.0 1.2 1 0 0 1 1 1 0 Aromatic-ring-opening dioxygenase LigAB, LigA subunit HhH-GPD PF00730.25 AIC14432.1 - 2.3e-11 44.1 0.0 3.6e-11 43.5 0.0 1.2 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein OGG_N PF07934.12 AIC14432.1 - 6.6e-11 42.3 0.0 6.7e-10 39.1 0.0 2.1 1 1 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain HHH PF00633.23 AIC14432.1 - 2.7e-05 23.8 0.0 7.1e-05 22.5 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_2 PF12826.7 AIC14432.1 - 0.00013 22.0 0.0 0.016 15.3 0.0 3.1 3 0 0 3 3 3 1 Helix-hairpin-helix motif HHH_5 PF14520.6 AIC14432.1 - 0.02 15.5 0.1 0.063 13.9 0.1 1.8 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_8 PF14716.6 AIC14432.1 - 0.022 15.1 0.1 0.043 14.2 0.1 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix domain AlkA_N PF06029.11 AIC14432.1 - 0.15 12.4 0.1 0.31 11.3 0.1 1.5 1 0 0 1 1 1 0 AlkA N-terminal domain AbrB-like PF14250.6 AIC14435.1 - 0.091 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 AbrB-like transcriptional regulator Abhydrolase_1 PF00561.20 AIC14436.1 - 7.6e-35 120.8 0.0 8.8e-25 87.8 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIC14436.1 - 2.7e-23 83.7 0.0 3.1e-23 83.5 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIC14436.1 - 5.6e-16 58.5 0.0 7.1e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 AIC14436.1 - 0.00023 21.1 0.0 0.00053 19.9 0.0 1.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold Ser_hydrolase PF06821.13 AIC14436.1 - 0.0041 17.0 0.0 1.8 8.4 0.0 2.3 2 0 0 2 2 2 2 Serine hydrolase Abhydrolase_5 PF12695.7 AIC14436.1 - 0.0099 15.7 0.0 3.4 7.4 0.0 2.2 2 0 0 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 AIC14436.1 - 0.019 14.8 0.0 3.6 7.3 0.0 2.6 2 1 0 2 2 2 0 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 AIC14436.1 - 0.022 14.9 0.0 0.047 13.8 0.0 1.5 1 0 0 1 1 1 0 TAP-like protein UPF0227 PF05728.12 AIC14436.1 - 0.037 14.0 0.0 0.085 12.8 0.0 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Peptidase_S10 PF00450.22 AIC14436.1 - 0.056 12.8 0.0 0.18 11.1 0.0 1.7 2 0 0 2 2 2 0 Serine carboxypeptidase HTH_45 PF14947.6 AIC14437.1 - 2.2e-19 69.2 0.1 3.4e-19 68.6 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC14437.1 - 0.0039 17.0 0.1 0.0044 16.8 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) RQC PF09382.10 AIC14437.1 - 0.065 13.0 0.1 0.15 11.8 0.0 1.6 1 1 1 2 2 2 0 RQC domain zinc_ribbon_10 PF10058.9 AIC14439.1 - 0.015 15.0 1.3 0.029 14.1 1.3 1.4 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein HscB_4_cys PF18256.1 AIC14439.1 - 0.065 13.1 3.1 0.7 9.8 0.2 2.3 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif zf-RRN7 PF11781.8 AIC14439.1 - 0.25 11.0 6.0 2 8.2 6.0 2.1 1 1 0 1 1 1 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF4282 PF14110.6 AIC14441.1 - 0.084 13.6 8.7 0.091 13.5 8.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) PQ-loop PF04193.14 AIC14441.1 - 0.1 12.4 3.7 0.29 10.9 0.3 2.1 1 1 1 2 2 2 0 PQ loop repeat DUF2207 PF09972.9 AIC14441.1 - 0.75 8.5 6.4 0.75 8.5 6.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4988 PF16378.5 AIC14442.1 - 0.015 15.0 0.4 0.015 15.0 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function RHH_1 PF01402.21 AIC14443.1 - 5.7e-06 26.1 0.0 8.6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family UBA_2 PF08587.11 AIC14443.1 - 0.078 13.1 0.0 0.097 12.8 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) DDE_Tnp_IS240 PF13610.6 AIC14444.1 - 6.2e-25 88.0 1.1 1e-24 87.3 1.1 1.3 1 0 0 1 1 1 1 DDE domain rve_3 PF13683.6 AIC14444.1 - 1.6e-07 31.0 0.0 4.2e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain rve PF00665.26 AIC14444.1 - 1.3e-05 25.4 0.1 4.2e-05 23.7 0.1 1.8 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.14 AIC14444.1 - 2.2e-05 24.1 0.0 4.3e-05 23.1 0.0 1.5 2 0 0 2 2 2 1 Transposase IS66 family Transposase_mut PF00872.18 AIC14444.1 - 0.0017 17.2 0.2 0.0036 16.2 0.0 1.5 2 0 0 2 2 2 1 Transposase, Mutator family Zn_Tnp_IS1 PF03811.13 AIC14444.1 - 0.038 13.7 4.9 0.081 12.7 4.9 1.5 1 0 0 1 1 1 0 InsA N-terminal domain Zn-ribbon_8 PF09723.10 AIC14444.1 - 0.11 12.7 1.2 1.9 8.6 0.2 2.6 2 0 0 2 2 2 0 Zinc ribbon domain DNA_RNApol_7kD PF03604.13 AIC14444.1 - 0.14 11.8 7.8 2.4 7.9 0.4 2.5 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit DUF3311 PF11755.8 AIC14445.1 - 0.02 14.8 0.7 0.044 13.7 0.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3311) NEMP PF10225.9 AIC14445.1 - 0.04 13.6 0.6 0.056 13.1 0.6 1.2 1 0 0 1 1 1 0 NEMP family DUF4293 PF14126.6 AIC14445.1 - 0.15 12.3 7.4 0.068 13.4 4.4 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4293) Copper-bind PF00127.20 AIC14446.1 - 4.8e-10 39.8 0.0 6.6e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC14446.1 - 2.2e-05 24.5 0.0 4.8e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Cupredoxin-like domain Cytochrome_B PF00033.19 AIC14447.1 - 2.1e-26 92.9 12.2 2.1e-26 92.9 12.2 2.3 3 0 0 3 3 3 1 Cytochrome b/b6/petB Cytochrom_B_N_2 PF13631.6 AIC14447.1 - 9.9e-25 87.5 8.8 9.9e-25 87.5 8.8 3.3 3 1 0 3 3 3 1 Cytochrome b(N-terminal)/b6/petB Cytochrom_B_C PF00032.17 AIC14447.1 - 1.2e-08 35.2 2.3 1.2e-08 35.2 2.3 3.5 5 1 0 5 5 5 1 Cytochrome b(C-terminal)/b6/petD DUF4405 PF14358.6 AIC14447.1 - 0.0063 17.0 3.4 0.0063 17.0 3.4 3.9 4 0 0 4 4 4 1 Domain of unknown function (DUF4405) UPF0542 PF15086.6 AIC14447.1 - 0.0071 16.3 2.4 0.0091 15.9 0.1 2.3 2 0 0 2 2 2 1 Uncharacterised protein family UPF0542 Phage_holin_3_6 PF07332.11 AIC14447.1 - 0.023 14.7 0.1 0.023 14.7 0.1 3.9 4 1 0 4 4 4 0 Putative Actinobacterial Holin-X, holin superfamily III Rieske PF00355.26 AIC14448.1 - 3.4e-06 26.9 0.0 5.5e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_signal PF10518.9 AIC14448.1 - 6.2e-05 22.7 0.3 0.00011 21.8 0.3 1.4 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 AIC14448.1 - 0.0038 16.6 0.1 0.0078 15.5 0.1 1.5 1 0 0 1 1 1 1 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal Pentapeptide PF00805.22 AIC14449.1 - 4.9e-26 90.0 8.8 9.1e-09 34.8 0.2 4.5 2 1 1 4 4 4 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 AIC14449.1 - 2.5e-18 66.0 2.2 1.5e-08 34.7 0.2 2.7 1 1 2 3 3 3 3 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 AIC14449.1 - 6.9e-11 42.1 0.6 1.3e-05 25.2 0.7 3.6 1 1 0 2 2 2 1 Pentapeptide repeats (9 copies) TP_methylase PF00590.20 AIC14450.1 - 6.9e-21 75.2 0.4 2.7e-20 73.2 0.0 1.9 2 0 0 2 2 2 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF357 PF04010.13 AIC14450.1 - 3e-16 59.3 0.6 2.2e-15 56.5 0.1 2.4 3 0 0 3 3 3 1 Protein of unknown function (DUF357) Peptidase_M20 PF01546.28 AIC14451.1 - 1.8e-28 99.7 0.0 2.7e-28 99.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AIC14451.1 - 3.7e-13 49.3 0.0 7e-13 48.4 0.0 1.5 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M28 PF04389.17 AIC14451.1 - 5.8e-05 22.9 0.0 0.00034 20.4 0.0 1.9 2 0 0 2 2 2 1 Peptidase family M28 Peptidase_M42 PF05343.14 AIC14451.1 - 0.0024 16.9 0.1 0.32 10.0 0.0 2.8 3 1 1 4 4 4 2 M42 glutamyl aminopeptidase Rimk_N PF18030.1 AIC14451.1 - 0.047 14.1 0.0 0.096 13.1 0.0 1.5 1 0 0 1 1 1 0 RimK PreATP-grasp domain RimK PF08443.11 AIC14452.1 - 2e-31 109.1 0.0 2.8e-31 108.6 0.0 1.2 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 AIC14452.1 - 5.2e-08 32.5 0.0 7.7e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 AIC14452.1 - 8.3e-07 29.2 0.0 1.4e-06 28.5 0.0 1.3 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AIC14452.1 - 1.3e-06 28.0 0.0 4.7e-06 26.2 0.0 2.0 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_ST PF14397.6 AIC14452.1 - 5.5e-05 22.6 0.0 0.015 14.6 0.0 2.6 2 1 1 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp PF02222.22 AIC14452.1 - 6.9e-05 22.5 0.0 0.00021 20.9 0.0 1.8 1 1 0 1 1 1 1 ATP-grasp domain Rimk_N PF18030.1 AIC14452.1 - 0.0011 19.3 0.0 0.0067 16.8 0.0 2.0 1 1 1 2 2 2 1 RimK PreATP-grasp domain ATP-grasp_5 PF13549.6 AIC14452.1 - 0.034 13.6 0.0 0.062 12.7 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain ATP-grasp_6 PF18419.1 AIC14452.1 - 0.12 12.0 0.1 0.26 11.0 0.1 1.5 1 0 0 1 1 1 0 ATP-grasp-like domain zinc_ribbon_4 PF13717.6 AIC14453.1 - 2.2e-05 24.3 2.0 0.033 14.1 0.1 2.3 1 1 1 2 2 2 2 zinc-ribbon domain zinc_ribbon_5 PF13719.6 AIC14453.1 - 0.00014 21.6 0.1 0.26 11.1 0.0 2.1 2 0 0 2 2 2 2 zinc-ribbon domain zf-RING_7 PF02591.15 AIC14453.1 - 0.00025 21.2 1.8 0.022 14.9 0.1 2.3 2 0 0 2 2 2 1 C4-type zinc ribbon domain zf-HYPF PF07503.12 AIC14453.1 - 0.00025 20.7 1.7 0.0021 17.8 1.7 1.9 1 1 0 1 1 1 1 HypF finger PhnA_Zn_Ribbon PF08274.12 AIC14453.1 - 0.00034 20.5 0.8 0.29 11.1 0.0 2.1 2 0 0 2 2 2 2 PhnA Zinc-Ribbon Prok-RING_1 PF14446.6 AIC14453.1 - 0.00035 20.4 4.5 0.00092 19.1 4.5 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 1 UPF0547 PF10571.9 AIC14453.1 - 0.00037 20.5 3.5 0.015 15.3 0.5 2.3 2 0 0 2 2 2 1 Uncharacterised protein family UPF0547 zf_UBZ PF18439.1 AIC14453.1 - 0.00071 19.1 0.8 0.58 9.8 0.2 2.3 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 AIC14453.1 - 0.0039 17.1 0.3 0.012 15.6 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid YacG PF03884.14 AIC14453.1 - 0.0043 16.7 0.6 2.5 7.9 0.0 2.2 2 0 0 2 2 2 2 DNA gyrase inhibitor YacG zf-TFIIB PF13453.6 AIC14453.1 - 0.0045 16.3 0.6 0.006 15.9 0.6 1.4 1 0 0 1 1 1 1 Transcription factor zinc-finger Zn-ribbon_8 PF09723.10 AIC14453.1 - 0.0045 17.1 2.6 0.0096 16.0 2.6 1.6 1 1 0 1 1 1 1 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 AIC14453.1 - 0.0046 16.9 1.0 2.6 8.2 0.1 2.3 2 0 0 2 2 2 2 NAD-dependent DNA ligase C4 zinc finger domain HypA PF01155.19 AIC14453.1 - 0.0048 16.9 0.1 0.0051 16.8 0.1 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AIC14453.1 - 0.006 15.9 5.6 0.85 9.1 5.6 2.2 1 1 0 1 1 1 1 zinc-ribbon domain Cys_rich_CPXG PF14255.6 AIC14453.1 - 0.0063 16.4 1.2 1.3 8.9 0.2 2.1 2 0 0 2 2 2 1 Cysteine-rich CPXCG zf-C4_Topoisom PF01396.19 AIC14453.1 - 0.0076 16.0 0.9 2 8.3 0.0 2.1 2 0 0 2 2 2 1 Topoisomerase DNA binding C4 zinc finger TF_Zn_Ribbon PF08271.12 AIC14453.1 - 0.0077 15.7 1.7 0.013 15.0 1.8 1.4 1 1 0 1 1 1 1 TFIIB zinc-binding zf-piccolo PF05715.13 AIC14453.1 - 0.0078 16.3 0.1 0.0092 16.1 0.1 1.1 1 0 0 1 1 1 1 Piccolo Zn-finger DZR PF12773.7 AIC14453.1 - 0.0096 15.9 0.5 0.014 15.4 0.5 1.3 1 1 0 1 1 1 1 Double zinc ribbon zinc-ribbons_6 PF07191.12 AIC14453.1 - 0.013 15.4 1.0 0.068 13.2 1.0 1.8 1 1 0 1 1 1 0 zinc-ribbons A2L_zn_ribbon PF08792.10 AIC14453.1 - 0.014 15.1 1.8 0.32 10.8 0.1 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain zinc_ribbon_2 PF13240.6 AIC14453.1 - 0.015 15.0 1.6 1.7 8.5 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-IS66 PF13005.7 AIC14453.1 - 0.016 15.6 3.4 0.51 10.8 0.3 2.4 1 1 1 2 2 2 0 zinc-finger binding domain of transposase IS66 Lar_restr_allev PF14354.6 AIC14453.1 - 0.02 15.3 1.3 0.031 14.7 1.3 1.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar CpXC PF14353.6 AIC14453.1 - 0.021 14.9 1.5 2.4 8.2 0.1 2.0 1 1 1 2 2 2 0 CpXC protein IBR PF01485.21 AIC14453.1 - 0.037 14.3 0.6 0.048 13.9 0.6 1.2 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zinc_ribbon_9 PF14369.6 AIC14453.1 - 0.039 14.2 3.0 0.12 12.6 3.0 1.7 1 1 0 1 1 1 0 zinc-ribbon OrfB_Zn_ribbon PF07282.11 AIC14453.1 - 0.046 13.6 0.1 0.062 13.2 0.1 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DNA_RNApol_7kD PF03604.13 AIC14453.1 - 0.083 12.6 2.8 0.26 11.0 2.8 1.7 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit Elf1 PF05129.13 AIC14453.1 - 0.094 12.8 0.1 0.12 12.4 0.1 1.2 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like TerY_C PF15616.6 AIC14453.1 - 0.11 12.6 0.4 0.7 10.0 0.4 1.9 1 1 0 1 1 1 0 TerY-C metal binding domain TRAF6_Z2 PF18048.1 AIC14453.1 - 0.12 12.5 1.8 4.3 7.5 0.3 2.2 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 Rubredoxin PF00301.20 AIC14453.1 - 0.13 12.4 2.2 7 6.8 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin Ogr_Delta PF04606.12 AIC14453.1 - 0.15 12.1 2.2 9.3 6.3 0.3 2.1 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger Zn_Tnp_IS1595 PF12760.7 AIC14453.1 - 0.15 12.1 2.2 1.7 8.7 0.1 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 AIC14453.1 - 0.16 12.5 0.5 13 6.5 0.0 2.1 2 0 0 2 2 2 0 Zinc-finger double domain Zn_Tnp_IS1 PF03811.13 AIC14453.1 - 0.16 11.7 0.8 12 5.8 0.1 2.2 2 0 0 2 2 2 0 InsA N-terminal domain zf-C2H2_3 PF13878.6 AIC14453.1 - 0.23 11.3 0.7 2.4 8.1 0.0 2.1 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-ACC PF17848.1 AIC14453.1 - 0.25 11.4 3.5 10 6.3 0.2 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Anti-TRAP PF15777.5 AIC14453.1 - 0.6 10.1 3.0 1.3 9.1 3.0 1.6 1 1 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF3797 PF12677.7 AIC14453.1 - 0.66 9.9 4.1 3.4 7.6 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3797) HMGL-like PF00682.19 AIC14454.1 - 6.6e-71 239.0 0.6 8.2e-71 238.6 0.6 1.1 1 0 0 1 1 1 1 HMGL-like Lyase_1 PF00206.20 AIC14455.1 - 7.6e-55 186.5 0.0 1.2e-54 185.8 0.0 1.3 1 0 0 1 1 1 1 Lyase ASL_C2 PF14698.6 AIC14455.1 - 4.9e-12 46.4 0.9 1e-11 45.4 0.0 2.1 2 0 0 2 2 2 1 Argininosuccinate lyase C-terminal FeS_assembly_P PF01883.19 AIC14457.1 - 1e-15 57.6 0.1 1.7e-15 57.0 0.1 1.3 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein HMA PF00403.26 AIC14457.1 - 0.094 13.2 0.1 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 Heavy-metal-associated domain BNR PF02012.20 AIC14458.1 - 4.4e-06 25.9 2.5 24 5.5 0.0 5.9 5 0 0 5 5 5 3 BNR/Asp-box repeat BNR_2 PF13088.6 AIC14458.1 - 4.8e-05 22.8 0.0 0.16 11.3 0.0 4.0 2 1 1 3 3 3 3 BNR repeat-like domain CyRPA PF18638.1 AIC14458.1 - 0.24 10.5 0.0 28 3.7 0.0 3.3 4 0 0 4 4 4 0 Cysteine-Rich Protective Antigen 6 bladed domain Fer2_3 PF13085.6 AIC14459.1 - 4.4e-29 100.7 0.1 1.5e-28 99.0 0.0 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_8 PF13183.6 AIC14459.1 - 2.1e-11 44.1 0.9 2.1e-11 44.1 0.9 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIC14459.1 - 2.6e-09 37.1 1.1 2.6e-09 37.1 1.1 2.1 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIC14459.1 - 1e-08 35.6 3.4 1.8e-08 34.8 0.5 2.4 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_7 PF12838.7 AIC14459.1 - 1.5e-07 31.8 2.1 1.5e-07 31.8 2.1 2.5 2 1 0 2 2 2 1 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIC14459.1 - 4.3e-07 30.0 10.1 1.3e-05 25.3 2.2 2.8 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer2 PF00111.27 AIC14459.1 - 1.3e-06 28.3 0.1 3.8e-06 26.8 0.1 1.8 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Fer4_16 PF13484.6 AIC14459.1 - 3e-06 28.0 1.4 3e-06 28.0 1.4 2.3 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain Fer4 PF00037.27 AIC14459.1 - 1.3e-05 24.8 1.0 1.3e-05 24.8 1.0 3.0 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_18 PF13746.6 AIC14459.1 - 0.00078 19.6 5.7 0.24 11.6 0.3 2.9 2 1 1 3 3 3 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIC14459.1 - 0.0035 17.3 3.1 0.0035 17.3 3.1 3.0 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_4 PF12800.7 AIC14459.1 - 0.0046 17.3 1.7 0.0046 17.3 1.7 3.1 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_22 PF17179.4 AIC14459.1 - 0.014 16.2 6.4 0.45 11.4 3.2 2.8 2 1 0 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIC14459.1 - 0.023 14.7 2.7 0.023 14.7 2.7 3.3 3 0 0 3 3 3 0 4Fe-4S binding domain FlhC PF05280.11 AIC14459.1 - 0.043 13.5 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Flagellar transcriptional activator (FlhC) Fer2_4 PF13510.6 AIC14459.1 - 0.091 12.8 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Fer4_15 PF13459.6 AIC14459.1 - 0.4 11.5 2.2 3.1 8.6 0.1 2.7 2 0 0 2 2 2 0 4Fe-4S single cluster domain Fer4_21 PF14697.6 AIC14459.1 - 6 7.1 16.3 0.77 9.9 8.8 2.6 2 1 0 2 2 1 0 4Fe-4S dicluster domain Sdh_cyt PF01127.22 AIC14460.1 - 1.6e-08 34.6 5.6 2.2e-08 34.2 5.6 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF4405 PF14358.6 AIC14460.1 - 0.014 15.9 0.6 0.014 15.9 0.6 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4405) Ferric_reduct PF01794.19 AIC14460.1 - 0.035 14.2 3.5 0.056 13.6 3.5 1.5 1 1 0 1 1 1 0 Ferric reductase like transmembrane component Fumarate_red_D PF02313.17 AIC14460.1 - 0.057 13.5 5.1 0.085 13.0 5.1 1.2 1 0 0 1 1 1 0 Fumarate reductase subunit D DUF808 PF05661.12 AIC14460.1 - 0.15 11.1 8.6 0.2 10.7 1.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF808) DUF1129 PF06570.11 AIC14460.1 - 0.19 11.2 4.7 0.049 13.1 1.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) Sdh_cyt PF01127.22 AIC14461.1 - 2.8e-13 49.9 0.3 3.5e-13 49.6 0.3 1.1 1 0 0 1 1 1 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit Fumarate_red_C PF02300.17 AIC14461.1 - 0.0051 16.9 0.5 0.021 14.9 0.1 1.8 2 0 0 2 2 2 1 Fumarate reductase subunit C Fumarate_red_D PF02313.17 AIC14461.1 - 0.12 12.5 0.1 0.12 12.5 0.1 2.1 2 0 0 2 2 2 0 Fumarate reductase subunit D DUF1206 PF06724.11 AIC14461.1 - 1.8 8.7 10.2 7.3 6.8 0.2 3.2 1 1 1 3 3 3 0 Domain of Unknown Function (DUF1206) FAD_binding_2 PF00890.24 AIC14462.1 - 4.2e-95 319.3 0.2 5.6e-95 318.9 0.2 1.2 1 0 0 1 1 1 1 FAD binding domain Succ_DH_flav_C PF02910.20 AIC14462.1 - 8.5e-37 126.0 0.8 1.4e-36 125.3 0.8 1.4 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Pyr_redox_2 PF07992.14 AIC14462.1 - 0.00076 18.8 0.1 0.0036 16.6 0.1 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 AIC14462.1 - 0.006 16.2 0.2 0.15 11.6 0.0 2.3 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 AIC14462.1 - 0.017 14.5 1.9 0.038 13.3 1.0 2.0 3 0 0 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.22 AIC14462.1 - 0.025 13.7 0.4 0.047 12.8 0.4 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 AIC14462.1 - 0.089 11.8 0.6 0.13 11.2 0.6 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein Thi4 PF01946.17 AIC14462.1 - 0.11 11.7 2.3 0.28 10.4 0.5 2.2 2 0 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 AIC14462.1 - 0.16 10.6 0.6 0.36 9.5 0.6 1.6 1 0 0 1 1 1 0 HI0933-like protein TPR_1 PF00515.28 AIC14463.1 - 1.3e-08 34.3 1.4 1.7e-06 27.6 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 AIC14463.1 - 5.1e-06 26.1 1.6 0.00092 18.9 1.2 3.0 3 0 0 3 3 3 1 TPR repeat TPR_2 PF07719.17 AIC14463.1 - 7.7e-06 25.6 3.0 4.9e-05 23.1 0.1 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 AIC14463.1 - 8.2e-06 26.2 0.1 0.29 12.1 0.0 2.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AIC14463.1 - 2e-05 24.6 0.1 0.25 11.5 0.0 2.2 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 AIC14463.1 - 0.00024 21.7 0.7 0.068 13.8 0.0 2.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 AIC14463.1 - 0.0048 17.0 0.4 0.015 15.4 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 AIC14463.1 - 0.012 16.2 0.1 2 9.2 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 AIC14463.1 - 0.019 15.5 1.2 0.19 12.3 0.4 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 AIC14463.1 - 0.14 12.4 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat tRNA-synt_His PF13393.6 AIC14467.1 - 4e-38 131.4 0.0 6.1e-38 130.8 0.0 1.3 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 AIC14467.1 - 1.1e-11 44.8 0.2 1.9e-11 43.9 0.2 1.4 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIC14467.1 - 1.2e-09 38.4 0.0 2.3e-09 37.5 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) TIR_2 PF13676.6 AIC14467.1 - 0.037 14.6 0.1 0.11 13.1 0.0 1.8 2 0 0 2 2 2 0 TIR domain tRNA-synt_2d PF01409.20 AIC14467.1 - 0.05 13.1 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 tRNA synthetases class II core domain (F) DUF2129 PF09902.9 AIC14468.1 - 0.011 15.8 0.1 0.014 15.4 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2129) ASL_C PF08328.11 AIC14468.1 - 0.011 15.8 0.3 0.013 15.6 0.3 1.1 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal RHH_1 PF01402.21 AIC14468.1 - 0.016 15.1 0.3 4.4 7.4 0.0 3.2 4 0 0 4 4 4 0 Ribbon-helix-helix protein, copG family PIN PF01850.21 AIC14469.1 - 7.9e-10 39.3 0.2 1e-09 38.9 0.2 1.1 1 0 0 1 1 1 1 PIN domain Archease PF01951.16 AIC14470.1 - 4.6e-38 130.6 0.2 5e-38 130.4 0.2 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) HSP20 PF00011.21 AIC14471.1 - 2.6e-20 72.5 1.4 4e-20 71.9 1.4 1.3 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AIC14471.1 - 1.2e-07 31.1 0.0 2e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA pPIWI_RE_REase PF18154.1 AIC14471.1 - 0.085 12.8 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 REase associating with pPIWI_RE NUC194 PF08163.12 AIC14471.1 - 0.21 10.5 0.1 0.28 10.1 0.1 1.1 1 0 0 1 1 1 0 NUC194 domain HATPase_c_5 PF14501.6 AIC14472.1 - 0.019 14.8 0.0 0.019 14.8 0.0 1.0 1 0 0 1 1 1 0 GHKL domain N6_Mtase PF02384.16 AIC14474.1 - 3.4e-13 49.5 0.0 8.5e-09 35.1 0.0 2.4 2 0 0 2 2 2 2 N-6 DNA Methylase UPF0020 PF01170.18 AIC14474.1 - 0.00015 21.5 0.0 0.011 15.5 0.0 2.5 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 Eco57I PF07669.11 AIC14474.1 - 0.0039 17.7 0.0 0.018 15.5 0.0 2.2 1 0 0 1 1 1 1 Eco57I restriction-modification methylase TaqI_C PF12950.7 AIC14474.1 - 0.013 15.6 0.7 0.047 13.8 0.0 2.3 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain MTS PF05175.14 AIC14474.1 - 0.044 13.3 0.0 2.9 7.4 0.0 2.5 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.6 AIC14474.1 - 0.13 12.0 0.1 3.4 7.4 0.0 2.7 2 0 0 2 2 2 0 Methyltransferase domain Ferritin PF00210.24 AIC14476.1 - 5.1e-22 78.3 0.0 7.2e-22 77.8 0.0 1.2 1 0 0 1 1 1 1 Ferritin-like domain DUF2250 PF10007.9 AIC14477.1 - 0.00076 19.5 0.0 0.0072 16.4 0.0 1.9 1 1 1 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) HTH_7 PF02796.15 AIC14477.1 - 0.00086 19.3 0.0 0.0018 18.3 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase TBPIP PF07106.13 AIC14477.1 - 0.001 18.9 0.3 0.0081 16.1 0.1 2.1 2 0 0 2 2 2 1 TBPIP/Hop2 winged helix domain HTH_IclR PF09339.10 AIC14477.1 - 0.0012 18.6 0.0 0.0025 17.6 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 AIC14477.1 - 0.0039 17.0 0.0 0.0049 16.7 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Mga PF05043.13 AIC14477.1 - 0.01 16.4 0.1 0.02 15.4 0.1 1.4 1 0 0 1 1 1 0 Mga helix-turn-helix domain HTH_Tnp_1_2 PF13022.6 AIC14477.1 - 0.02 15.0 0.4 0.097 12.8 0.3 2.0 1 1 0 1 1 1 0 Helix-turn-helix of insertion element transposase HTH_23 PF13384.6 AIC14477.1 - 0.03 14.1 0.0 0.059 13.2 0.0 1.4 1 0 0 1 1 1 0 Homeodomain-like domain HTH_11 PF08279.12 AIC14477.1 - 0.032 14.2 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 AIC14477.1 - 0.041 13.5 0.0 0.085 12.4 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 AIC14477.1 - 0.05 13.9 0.0 0.18 12.2 0.0 1.8 1 1 1 2 2 2 0 Transcriptional regulator FUR PF01475.19 AIC14477.1 - 0.087 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Ferric uptake regulator family XPG_I PF00867.18 AIC14478.1 - 2.2e-24 85.6 0.0 5e-24 84.5 0.0 1.6 1 0 0 1 1 1 1 XPG I-region XPG_N PF00752.17 AIC14478.1 - 3.4e-19 69.2 0.0 7.3e-19 68.1 0.0 1.5 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 AIC14478.1 - 4.4e-06 27.2 0.0 1.1e-05 25.9 0.0 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold HHH_5 PF14520.6 AIC14478.1 - 0.026 15.1 0.0 0.064 13.9 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain HHH_2 PF12826.7 AIC14478.1 - 0.077 13.1 0.0 4.6 7.4 0.0 2.7 2 0 0 2 2 2 0 Helix-hairpin-helix motif MCM PF00493.23 AIC14479.1 - 2.9e-07 29.8 0.1 0.0019 17.3 0.0 2.6 1 1 1 2 2 2 2 MCM P-loop domain Sigma54_activat PF00158.26 AIC14479.1 - 3.2e-05 23.7 0.0 0.00013 21.7 0.0 1.9 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_3 PF07726.11 AIC14479.1 - 0.00053 19.8 0.0 0.0051 16.7 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 AIC14479.1 - 0.0024 17.9 0.1 0.14 12.1 0.1 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 AIC14479.1 - 0.014 15.8 0.1 0.087 13.2 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AIC14479.1 - 0.017 15.4 0.0 0.17 12.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AIC14479.1 - 0.018 15.5 0.0 0.15 12.4 0.0 2.4 1 1 0 1 1 1 0 AAA ATPase domain RuvB_N PF05496.12 AIC14479.1 - 0.059 13.1 0.0 0.17 11.6 0.0 1.8 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain DNA_pol3_delta2 PF13177.6 AIC14479.1 - 0.077 12.8 0.2 1 9.1 0.2 2.5 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Glyco_hydro_14 PF01373.17 AIC14480.1 - 0.00027 20.0 0.0 0.00027 20.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 14 T4_Gp59_N PF08993.10 AIC14480.1 - 0.07 13.5 0.1 0.13 12.6 0.0 1.6 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase zf-NADH-PPase PF09297.11 AIC14481.1 - 0.0052 16.4 3.5 0.077 12.7 0.8 2.2 2 0 0 2 2 2 1 NADH pyrophosphatase zinc ribbon domain Zn-ribbon_8 PF09723.10 AIC14481.1 - 0.0092 16.1 4.8 0.048 13.8 4.8 1.9 1 1 0 1 1 1 1 Zinc ribbon domain TFIIS_C PF01096.18 AIC14481.1 - 0.012 15.4 2.1 0.42 10.5 0.1 2.6 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) DZR PF12773.7 AIC14481.1 - 0.027 14.5 0.9 0.039 14.0 0.9 1.2 1 0 0 1 1 1 0 Double zinc ribbon TF_Zn_Ribbon PF08271.12 AIC14481.1 - 0.072 12.6 0.7 4.2 7.0 0.1 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding Peptidase_C74 PF12387.8 AIC14481.1 - 0.26 10.7 2.1 0.43 10.0 2.1 1.3 1 0 0 1 1 1 0 Pestivirus NS2 peptidase zf_UBZ PF18439.1 AIC14481.1 - 0.7 9.5 2.7 4.1 7.1 0.2 2.1 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger Rubredoxin_2 PF18073.1 AIC14481.1 - 0.73 9.6 5.5 3.4 7.5 5.5 2.0 1 1 0 1 1 1 0 Rubredoxin metal binding domain DUF4191 PF13829.6 AIC14481.1 - 1.1 8.5 4.1 1.2 8.4 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Ogr_Delta PF04606.12 AIC14481.1 - 1.8 8.6 4.7 2.8 8.0 0.9 2.2 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-C2H2_4 PF13894.6 AIC14483.1 - 0.00098 19.8 0.3 0.0014 19.3 0.3 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC14483.1 - 0.034 14.6 0.2 0.049 14.1 0.2 1.3 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIC14483.1 - 0.038 14.0 0.8 0.052 13.6 0.8 1.3 1 0 0 1 1 1 0 C2H2-type zinc finger DUF1244 PF06844.11 AIC14483.1 - 0.059 13.5 0.1 0.06 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) Prok-JAB PF14464.6 AIC14485.1 - 1.4e-08 34.5 0.0 1e-07 31.7 0.0 2.0 1 1 0 1 1 1 1 Prokaryotic homologs of the JAB domain DDE_Tnp_IS240 PF13610.6 AIC14486.1 - 2.3e-10 40.8 0.1 3.7e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 DDE domain PqqD PF05402.12 AIC14487.1 - 3.5e-06 27.2 0.0 4.4e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) CHB_HEX_C_1 PF13290.6 AIC14489.1 - 1.4e-32 111.5 28.3 6.2e-17 61.4 4.9 3.8 4 0 0 4 4 4 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIC14489.1 - 2.7e-30 104.3 15.1 7e-16 58.1 2.7 3.3 2 0 0 2 2 2 2 Fn3 associated Polysacc_deac_1 PF01522.21 AIC14489.1 - 4.1e-10 39.6 0.1 1e-09 38.3 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide deacetylase HYR PF02494.16 AIC14489.1 - 3.6e-08 33.6 12.2 1.6e-06 28.4 0.9 4.6 4 2 0 4 4 4 2 HYR domain CHB_HEX_C PF03174.13 AIC14489.1 - 5.6e-07 29.5 0.8 0.017 15.1 0.0 3.3 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain Big_3_4 PF13754.6 AIC14489.1 - 0.0018 18.0 0.1 4.7 7.0 0.0 3.8 3 0 0 3 3 3 1 Domain of unknown function Glyco_hydro_57 PF03065.15 AIC14489.1 - 0.007 15.6 0.0 0.012 14.8 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 ASH PF15780.5 AIC14489.1 - 0.04 14.1 0.3 0.17 12.1 0.3 2.1 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Abhydrolase_1 PF00561.20 AIC14490.1 - 1.4e-15 57.7 0.0 3.4e-15 56.4 0.0 1.6 1 1 0 1 1 1 1 alpha/beta hydrolase fold PhaC_N PF07167.13 AIC14490.1 - 1.7e-12 47.3 0.0 3.2e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus Hydrolase_4 PF12146.8 AIC14490.1 - 5.4e-11 42.2 0.0 1.7e-05 24.2 0.0 2.5 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DUF3141 PF11339.8 AIC14490.1 - 0.0016 17.0 0.0 0.0025 16.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3141) PHB_depo_C PF06850.11 AIC14490.1 - 0.0026 17.3 0.0 0.024 14.1 0.0 2.2 2 1 0 2 2 2 1 PHB de-polymerase C-terminus PDDEXK_10 PF07788.11 AIC14490.1 - 0.008 16.1 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily DLH PF01738.18 AIC14490.1 - 0.01 15.4 0.0 0.072 12.6 0.0 2.1 2 0 0 2 2 2 0 Dienelactone hydrolase family FSH1 PF03959.13 AIC14490.1 - 0.059 13.0 0.0 0.29 10.8 0.0 2.0 2 1 0 2 2 2 0 Serine hydrolase (FSH1) PHA_synth_III_E PF09712.10 AIC14491.1 - 1.2e-22 80.4 0.2 1.6e-22 80.0 0.2 1.1 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) SRP1_TIP1 PF00660.17 AIC14491.1 - 0.0015 18.5 0.5 0.0057 16.7 0.2 2.2 2 1 0 2 2 2 1 Seripauperin and TIP1 family DUF2730 PF10805.8 AIC14491.1 - 0.039 14.1 0.7 0.85 9.7 0.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2730) ARL2_Bind_BART PF11527.8 AIC14491.1 - 0.063 13.4 0.4 0.17 12.0 0.4 1.8 1 0 0 1 1 1 0 The ARF-like 2 binding protein BART LPD34 PF18852.1 AIC14491.1 - 0.18 11.4 0.1 0.18 11.4 0.1 1.7 2 0 0 2 2 2 0 Large polyvalent protein associated domain 34 Monooxygenase_B PF04744.12 AIC14492.1 - 0.00065 18.7 0.4 0.0011 17.8 0.0 1.5 2 0 0 2 2 2 1 Monooxygenase subunit B protein DUF3467 PF11950.8 AIC14493.1 - 0.16 12.2 0.0 0.35 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3467) FAM195 PF14799.6 AIC14494.1 - 0.011 16.1 0.0 0.015 15.6 0.0 1.2 1 0 0 1 1 1 0 FAM195 family Pho88 PF10032.9 AIC14495.1 - 0.075 12.3 0.0 0.09 12.0 0.0 1.1 1 0 0 1 1 1 0 Phosphate transport (Pho88) HTH_Crp_2 PF13545.6 AIC14497.1 - 0.00036 20.5 0.0 0.0005 20.0 0.0 1.3 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_36 PF13730.6 AIC14497.1 - 0.072 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 AIC14497.1 - 0.12 12.3 0.2 2.5 8.0 0.0 2.2 1 1 1 2 2 2 0 Homeodomain-like domain Gmad2 PF10648.9 AIC14499.1 - 0.007 16.6 0.2 0.18 12.1 0.0 2.1 1 1 1 2 2 2 1 Immunoglobulin-like domain of bacterial spore germination Transglut_C PF00927.22 AIC14499.1 - 0.031 14.4 0.1 0.042 14.0 0.1 1.3 1 0 0 1 1 1 0 Transglutaminase family, C-terminal ig like domain DUF3094 PF11293.8 AIC14499.1 - 0.22 11.3 1.1 0.46 10.2 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3094) ATP-grasp_5 PF13549.6 AIC14502.1 - 1.4e-61 207.8 0.3 2e-61 207.3 0.3 1.3 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 AIC14502.1 - 3.8e-46 156.3 0.1 1.2e-45 154.7 0.1 1.9 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AIC14502.1 - 2.7e-21 76.2 0.0 7.9e-21 74.7 0.0 1.9 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 AIC14502.1 - 2.7e-10 40.8 0.2 1.3e-09 38.6 0.2 2.3 1 0 0 1 1 1 1 CoA binding domain ATP-grasp_2 PF08442.10 AIC14502.1 - 0.065 12.8 0.4 0.15 11.6 0.1 1.8 2 0 0 2 2 2 0 ATP-grasp domain F420_oxidored PF03807.17 AIC14502.1 - 0.1 13.2 0.1 0.36 11.4 0.1 2.0 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GATase PF00117.28 AIC14503.1 - 9.4e-20 71.2 0.0 1.3e-19 70.7 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIC14503.1 - 8e-08 32.3 0.4 2.9e-07 30.4 0.4 1.9 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 AIC14503.1 - 0.0035 17.2 0.0 0.0066 16.3 0.0 1.5 1 0 0 1 1 1 1 DJ-1/PfpI family GATase_3 PF07685.14 AIC14503.1 - 0.012 15.2 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Toprim_4 PF13662.6 AIC14504.1 - 1.5e-05 25.4 0.0 3.7e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Toprim domain Toprim PF01751.22 AIC14504.1 - 5.2e-05 23.4 0.0 0.00054 20.1 0.0 2.1 1 1 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 AIC14504.1 - 0.02 15.3 0.0 0.031 14.7 0.0 1.5 1 1 0 1 1 1 0 Toprim-like Toprim_4 PF13662.6 AIC14505.1 - 1.6e-09 38.1 0.8 4e-09 36.8 0.8 1.7 1 0 0 1 1 1 1 Toprim domain Toprim_2 PF13155.6 AIC14505.1 - 1.7e-06 28.4 0.0 4.9e-06 26.9 0.0 1.8 2 0 0 2 2 2 1 Toprim-like Toprim PF01751.22 AIC14505.1 - 0.017 15.4 0.3 0.09 13.0 0.3 2.2 1 1 0 1 1 1 0 Toprim domain GRP PF07172.11 AIC14505.1 - 0.22 12.2 12.2 0.47 11.2 12.2 1.5 1 0 0 1 1 1 0 Glycine rich protein family CTP-dep_RFKase PF01982.16 AIC14506.1 - 9e-42 142.0 0.0 1.2e-41 141.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function DUF120 HTH_27 PF13463.6 AIC14506.1 - 0.00075 19.9 0.1 0.0014 19.1 0.1 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR_2 PF12802.7 AIC14506.1 - 0.0013 18.6 0.1 0.0023 17.8 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 AIC14506.1 - 0.0022 18.0 0.0 0.0038 17.3 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 AIC14506.1 - 0.0024 17.7 0.0 0.0045 16.9 0.0 1.5 1 0 0 1 1 1 1 MarR family HTH_34 PF13601.6 AIC14506.1 - 0.0036 17.5 0.1 0.011 15.9 0.1 1.9 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_Crp_2 PF13545.6 AIC14506.1 - 0.0078 16.2 0.1 0.015 15.3 0.1 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 AIC14506.1 - 0.018 14.6 0.0 0.035 13.7 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding AbiEi_4 PF13338.6 AIC14506.1 - 0.038 14.2 0.1 0.11 12.7 0.1 1.8 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin TrmB PF01978.19 AIC14506.1 - 0.042 13.7 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_36 PF13730.6 AIC14506.1 - 0.11 12.4 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain LexA_DNA_bind PF01726.16 AIC14506.1 - 0.12 12.2 0.0 0.32 10.8 0.0 1.7 1 0 0 1 1 1 0 LexA DNA binding domain HTH_11 PF08279.12 AIC14506.1 - 0.12 12.3 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 HTH domain CTP_transf_like PF01467.26 AIC14507.1 - 1.5e-08 35.0 0.0 2.1e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like MazG PF03819.17 AIC14507.1 - 0.0052 16.9 0.0 1.5 9.0 0.0 2.5 2 0 0 2 2 2 2 MazG nucleotide pyrophosphohydrolase domain Methyltransf_31 PF13847.6 AIC14508.1 - 5.1e-30 104.3 0.0 2.1e-29 102.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC14508.1 - 3.4e-19 69.3 0.0 5.9e-19 68.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC14508.1 - 4.1e-17 62.7 0.1 1.2e-16 61.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14508.1 - 3.3e-16 59.7 0.0 7.4e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC14508.1 - 4.4e-16 59.4 0.0 8.1e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC14508.1 - 1.2e-08 34.6 0.1 2.2e-08 33.8 0.1 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 AIC14508.1 - 3.8e-08 33.0 0.0 6.1e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 AIC14508.1 - 7.2e-07 28.9 0.0 1.2e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 AIC14508.1 - 8e-07 28.7 0.0 3.5e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase Methyltransf_2 PF00891.18 AIC14508.1 - 1.6e-06 27.6 0.1 3e-06 26.7 0.0 1.5 2 0 0 2 2 2 1 O-methyltransferase domain PCMT PF01135.19 AIC14508.1 - 8.5e-06 25.7 0.0 1.3e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DREV PF05219.12 AIC14508.1 - 8.3e-05 21.8 0.1 0.00019 20.7 0.0 1.6 2 0 0 2 2 2 1 DREV methyltransferase PrmA PF06325.13 AIC14508.1 - 0.00015 21.3 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MetW PF07021.12 AIC14508.1 - 0.0019 17.8 0.0 0.0035 17.0 0.0 1.3 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_32 PF13679.6 AIC14508.1 - 0.0047 16.9 0.0 0.0066 16.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 AIC14508.1 - 0.012 15.3 0.0 0.026 14.1 0.0 1.5 1 1 0 1 1 1 0 Nodulation protein S (NodS) DUF938 PF06080.12 AIC14508.1 - 0.026 14.3 0.0 0.053 13.3 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF938) Methyltransf_9 PF08003.11 AIC14508.1 - 0.029 13.3 0.0 0.04 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Nre_N PF04894.12 AIC14509.1 - 3e-82 276.5 0.0 4.1e-82 276.1 0.0 1.1 1 0 0 1 1 1 1 Archaeal Nre, N-terminal Nre_C PF04895.12 AIC14509.1 - 1.5e-36 124.6 0.0 2.7e-36 123.8 0.0 1.4 1 0 0 1 1 1 1 Archaeal Nre, C-terminal Psb28 PF03912.14 AIC14510.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Psb28 protein rve PF00665.26 AIC14511.1 - 8.1e-21 74.4 0.1 2.4e-20 72.9 0.0 1.8 2 0 0 2 2 2 1 Integrase core domain HTH_29 PF13551.6 AIC14511.1 - 1.9e-13 50.2 2.7 4.5e-12 45.8 0.1 3.3 4 0 0 4 4 4 1 Winged helix-turn helix HTH_28 PF13518.6 AIC14511.1 - 2.5e-13 49.9 5.4 1.7e-11 44.0 0.3 3.5 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_32 PF13565.6 AIC14511.1 - 5.3e-13 49.4 1.0 1.5e-12 47.9 0.2 2.2 2 0 0 2 2 2 1 Homeodomain-like domain HTH_23 PF13384.6 AIC14511.1 - 7.2e-13 47.9 1.3 1.3e-10 40.8 0.1 2.7 2 0 0 2 2 2 1 Homeodomain-like domain LZ_Tnp_IS481 PF13011.6 AIC14511.1 - 1.1e-11 45.1 0.3 8.8e-10 39.0 0.0 2.9 3 0 0 3 3 3 1 leucine-zipper of insertion element IS481 rve_3 PF13683.6 AIC14511.1 - 1.1e-07 31.5 0.1 7.6e-07 28.8 0.0 2.4 3 0 0 3 3 3 1 Integrase core domain HTH_Tnp_1 PF01527.20 AIC14511.1 - 2.9e-07 30.7 0.0 1.5e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Transposase HTH_33 PF13592.6 AIC14511.1 - 9.4e-05 22.0 0.2 0.00072 19.1 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn helix HTH_Tnp_1_2 PF13022.6 AIC14511.1 - 0.00022 21.3 0.0 0.00067 19.8 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix of insertion element transposase Terminase_5 PF06056.12 AIC14511.1 - 0.0011 18.9 0.6 0.021 14.7 0.0 2.5 2 0 0 2 2 2 1 Putative ATPase subunit of terminase (gpP-like) HTH_7 PF02796.15 AIC14511.1 - 0.0035 17.4 2.8 0.031 14.4 0.2 2.6 2 0 0 2 2 2 1 Helix-turn-helix domain of resolvase HTH_Tnp_Tc3_2 PF01498.18 AIC14511.1 - 0.0082 16.4 0.1 0.049 13.9 0.2 2.2 2 0 0 2 2 2 1 Transposase HTH_Tnp_IS630 PF01710.16 AIC14511.1 - 0.01 15.9 4.0 0.1 12.7 0.0 2.8 2 1 0 2 2 2 0 Transposase DDE_Tnp_IS240 PF13610.6 AIC14511.1 - 0.013 15.8 0.3 0.026 14.8 0.3 1.5 1 0 0 1 1 1 0 DDE domain DDE_3 PF13358.6 AIC14511.1 - 0.018 14.8 0.0 0.042 13.6 0.0 1.6 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_36 PF13730.6 AIC14511.1 - 0.02 14.8 0.7 0.073 13.0 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_AraC PF00165.23 AIC14511.1 - 0.029 14.5 0.9 0.13 12.3 0.0 2.6 3 0 0 3 3 3 0 Bacterial regulatory helix-turn-helix proteins, AraC family HTH_21 PF13276.6 AIC14511.1 - 0.034 14.3 0.7 0.072 13.2 0.2 1.8 2 0 0 2 2 1 0 HTH-like domain DUF1153 PF06627.11 AIC14511.1 - 0.055 13.6 0.1 0.24 11.6 0.0 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF1153) CENP-B_N PF04218.13 AIC14511.1 - 0.07 12.8 0.0 0.19 11.4 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_17 PF12728.7 AIC14511.1 - 0.34 11.1 3.7 17 5.7 0.0 3.2 2 0 0 2 2 2 0 Helix-turn-helix domain ProRS-C_1 PF09180.11 AIC14512.1 - 2.3e-24 85.4 0.4 5.1e-24 84.3 0.4 1.6 1 0 0 1 1 1 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 AIC14512.1 - 3.2e-20 72.1 0.7 6.1e-20 71.2 0.7 1.5 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIC14512.1 - 1.6e-18 67.3 0.0 2.4e-18 66.7 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) OpcA PF07239.11 AIC14512.1 - 0.056 13.1 0.2 0.12 12.0 0.2 1.6 1 1 0 1 1 1 0 Outer membrane protein OpcA TIR_2 PF13676.6 AIC14512.1 - 0.15 12.6 0.1 1 10.0 0.1 2.3 3 0 0 3 3 3 0 TIR domain SNARE_assoc PF09335.11 AIC14513.1 - 6.8e-16 58.8 1.7 6.8e-16 58.8 1.7 2.4 2 1 1 3 3 3 1 SNARE associated Golgi protein zinc_ribbon_4 PF13717.6 AIC14515.1 - 0.0027 17.6 1.4 0.39 10.7 0.1 2.2 2 0 0 2 2 2 2 zinc-ribbon domain DUF2387 PF09526.10 AIC14515.1 - 0.0047 17.0 0.6 0.0052 16.9 0.6 1.1 1 0 0 1 1 1 1 Probable metal-binding protein (DUF2387) PADR1 PF08063.12 AIC14515.1 - 0.0085 15.9 1.2 0.011 15.5 1.2 1.2 1 0 0 1 1 1 1 PADR1 (NUC008) domain Zn_Tnp_IS1595 PF12760.7 AIC14515.1 - 0.02 14.9 0.3 0.02 14.9 0.3 1.1 1 0 0 1 1 1 0 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.16 AIC14515.1 - 0.036 13.9 1.5 0.16 11.8 1.5 1.9 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit Elf1 PF05129.13 AIC14515.1 - 0.038 14.0 1.1 0.044 13.8 1.1 1.1 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Lar_restr_allev PF14354.6 AIC14515.1 - 0.053 13.9 1.1 0.06 13.7 1.1 1.1 1 0 0 1 1 1 0 Restriction alleviation protein Lar Auto_anti-p27 PF06677.12 AIC14515.1 - 0.057 13.6 2.7 0.083 13.1 2.7 1.4 1 1 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) C1_4 PF07975.12 AIC14515.1 - 0.12 12.7 3.3 0.46 10.7 3.4 1.8 1 1 1 2 2 2 0 TFIIH C1-like domain zinc_ribbon_5 PF13719.6 AIC14515.1 - 0.13 12.1 5.6 1 9.2 0.5 2.1 1 1 1 2 2 2 0 zinc-ribbon domain zf-TFIIB PF13453.6 AIC14515.1 - 0.28 10.6 3.0 0.47 9.8 3.0 1.4 1 1 0 1 1 1 0 Transcription factor zinc-finger zf_UBZ PF18439.1 AIC14515.1 - 0.62 9.7 2.7 6.6 6.4 0.2 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-H2C2_2 PF13465.6 AIC14515.1 - 3 8.4 7.6 1.2 9.7 0.6 2.1 1 1 1 2 2 2 0 Zinc-finger double domain SMC_N PF02463.19 AIC14516.1 - 5.8e-62 209.0 0.0 1.2e-61 207.9 0.0 1.7 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AIC14516.1 - 1.2e-15 58.1 8.0 9.5e-09 35.4 0.0 3.4 2 2 0 2 2 2 2 AAA ATPase domain SMC_hinge PF06470.13 AIC14516.1 - 4.7e-14 52.7 0.0 3.6e-13 49.8 0.0 2.4 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 AIC14516.1 - 1.3e-13 51.5 2.4 9.6e-06 25.6 0.5 3.1 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AIC14516.1 - 2.3e-11 44.6 28.0 2.3e-11 44.6 28.0 6.4 2 2 0 2 2 1 1 AAA domain AAA_29 PF13555.6 AIC14516.1 - 5.5e-07 29.2 0.0 1.3e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SHE3 PF17078.5 AIC14516.1 - 0.00036 20.3 13.0 0.00036 20.3 13.0 5.7 3 2 1 4 4 4 1 SWI5-dependent HO expression protein 3 Spc7 PF08317.11 AIC14516.1 - 0.00061 18.8 89.6 0.0089 14.9 14.3 6.4 2 2 4 6 6 6 4 Spc7 kinetochore protein Filament PF00038.21 AIC14516.1 - 0.0034 17.0 21.6 0.0034 17.0 21.6 6.1 2 2 1 4 4 4 2 Intermediate filament protein CENP-F_leu_zip PF10473.9 AIC14516.1 - 0.0037 17.3 6.3 0.0037 17.3 6.3 7.1 3 2 3 6 6 6 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SbcCD_C PF13558.6 AIC14516.1 - 0.0067 16.6 0.3 0.054 13.7 0.0 2.7 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF4201 PF13870.6 AIC14516.1 - 0.011 15.5 60.7 0.042 13.6 4.8 6.8 3 2 2 6 6 6 0 Domain of unknown function (DUF4201) ABC_tran PF00005.27 AIC14516.1 - 0.019 15.5 0.5 0.019 15.5 0.5 5.2 2 2 1 3 3 3 0 ABC transporter MscS_porin PF12795.7 AIC14516.1 - 0.15 11.6 91.2 0.17 11.4 7.8 5.4 2 2 3 5 5 5 0 Mechanosensitive ion channel porin domain DUF1664 PF07889.12 AIC14516.1 - 1.1 9.3 53.5 0.32 11.0 0.6 8.3 4 2 5 9 9 9 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 AIC14516.1 - 1.4 9.4 21.1 1.1 9.8 0.1 6.4 4 2 2 7 7 7 0 Nucleopolyhedrovirus P10 protein Inos-1-P_synth PF01658.17 AIC14517.1 - 6e-26 90.8 0.0 9.7e-26 90.2 0.0 1.3 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Acetyltransf_7 PF13508.7 AIC14518.1 - 1.5e-06 28.5 0.0 2.7e-06 27.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AIC14518.1 - 1.2e-05 25.6 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AIC14518.1 - 2.6e-05 24.1 0.0 4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIC14518.1 - 0.19 11.8 0.0 0.58 10.2 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain tRNA-synt_1e PF01406.19 AIC14519.1 - 1.4e-70 238.1 0.0 1.8e-70 237.7 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 AIC14519.1 - 7.8e-14 51.2 0.0 1.1e-06 27.7 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AIC14519.1 - 3.8e-09 35.3 0.0 2.4e-07 29.4 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1f PF01921.18 AIC14519.1 - 5.9e-08 32.0 0.0 0.0073 15.3 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (K) DALR_2 PF09190.11 AIC14519.1 - 0.0011 19.4 0.9 0.0041 17.6 0.3 2.2 1 1 1 2 2 2 1 DALR domain tRNA-synt_1c PF00749.21 AIC14519.1 - 0.0043 16.0 0.0 0.025 13.5 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain Radical_SAM PF04055.21 AIC14520.1 - 6.7e-13 49.3 0.2 1.1e-12 48.6 0.2 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AIC14520.1 - 1.3e-05 25.3 0.1 2.9e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 AIC14520.1 - 5.6e-05 23.4 0.2 0.00016 21.9 0.1 1.7 1 1 0 1 1 1 1 4Fe-4S single cluster domain SPASM PF13186.6 AIC14520.1 - 0.0074 16.8 1.8 0.022 15.3 1.8 1.9 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain LysE PF01810.18 AIC14521.1 - 1.2e-17 64.0 13.3 1.5e-17 63.7 13.3 1.1 1 0 0 1 1 1 1 LysE type translocator Alba PF01918.21 AIC14522.1 - 1.7e-14 53.3 0.3 2.3e-14 52.9 0.3 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 AIC14522.1 - 0.014 15.3 0.4 0.044 13.7 0.4 1.8 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P SGL PF08450.12 AIC14524.1 - 5.1e-10 39.4 1.7 0.0013 18.4 0.0 5.0 5 0 0 5 5 5 3 SMP-30/Gluconolactonase/LRE-like region Reg_prop PF07494.11 AIC14524.1 - 1.6e-06 27.6 5.8 12 6.5 0.3 6.7 6 0 0 6 6 6 2 Two component regulator propeller SBBP PF06739.11 AIC14524.1 - 0.0011 18.9 6.3 0.4 10.7 0.2 4.3 5 0 0 5 5 5 2 Beta-propeller repeat NHL PF01436.21 AIC14524.1 - 0.022 14.8 0.7 9.7 6.4 0.1 4.5 5 0 0 5 5 5 0 NHL repeat Glyco_hydro_5_C PF18564.1 AIC14524.1 - 0.089 13.3 0.0 4.1 8.0 0.0 3.3 2 1 1 3 3 3 0 Glycoside hydrolase family 5 C-terminal domain EamA PF00892.20 AIC14525.1 - 7e-36 123.4 40.5 7.8e-18 65.0 20.6 2.1 2 0 0 2 2 2 2 EamA-like transporter family TPT PF03151.16 AIC14525.1 - 1.5e-05 24.5 18.8 0.00013 21.4 8.7 2.2 1 1 1 2 2 2 2 Triose-phosphate Transporter family SLATT_3 PF18184.1 AIC14525.1 - 0.17 12.0 0.2 0.17 12.0 0.2 2.7 3 2 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 3 DUF3852 PF12963.7 AIC14525.1 - 0.7 10.3 0.1 0.7 10.3 0.1 3.3 3 2 1 4 4 4 0 Protein of unknown function (DUF3852) PTH2 PF01981.16 AIC14526.1 - 5.1e-42 142.9 0.1 5.6e-42 142.7 0.1 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 FAD_binding_3 PF01494.19 AIC14527.1 - 6.9e-11 42.0 4.3 1.3e-07 31.2 4.3 2.2 1 1 0 1 1 1 1 FAD binding domain DAO PF01266.24 AIC14527.1 - 4.8e-08 33.0 8.4 0.00061 19.5 0.2 2.4 1 1 0 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.7 AIC14527.1 - 2.3e-07 30.6 0.9 3.4e-07 30.0 0.9 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AIC14527.1 - 3.2e-05 22.8 1.3 0.016 13.9 0.5 2.2 2 0 0 2 2 2 2 HI0933-like protein Pyr_redox_2 PF07992.14 AIC14527.1 - 5.9e-05 22.4 1.5 0.016 14.4 0.8 2.3 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIC14527.1 - 0.00012 21.4 1.0 0.1 11.9 0.0 2.2 1 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AIC14527.1 - 0.00037 19.7 3.2 0.0005 19.3 1.6 2.0 3 0 0 3 3 3 1 FAD binding domain Thi4 PF01946.17 AIC14527.1 - 0.00042 19.6 0.6 0.001 18.4 0.6 1.6 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 AIC14527.1 - 0.0018 18.5 0.5 0.0018 18.5 0.5 2.8 3 0 0 3 3 3 1 NAD(P)-binding Rossmann-like domain Trp_halogenase PF04820.14 AIC14527.1 - 0.003 16.5 3.0 0.28 10.0 0.0 3.0 2 1 0 2 2 2 1 Tryptophan halogenase Amino_oxidase PF01593.24 AIC14527.1 - 0.0064 15.8 2.9 0.19 11.0 1.0 2.3 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Lycopene_cycl PF05834.12 AIC14527.1 - 0.017 14.2 1.2 6.2 5.8 0.0 2.5 2 1 0 2 2 2 0 Lycopene cyclase protein GIDA PF01134.22 AIC14527.1 - 0.19 10.7 3.3 0.6 9.1 3.2 1.8 1 1 0 1 1 1 0 Glucose inhibited division protein A Pyr_redox PF00070.27 AIC14527.1 - 2.8 8.5 4.9 2.6 8.7 1.2 2.8 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DUF1610 PF07754.11 AIC14528.1 - 8.1e-08 32.1 6.4 8.1e-08 32.1 6.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF1610) DZR PF12773.7 AIC14528.1 - 0.015 15.3 7.9 0.094 12.8 8.2 2.1 1 1 1 2 2 2 0 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC14528.1 - 0.078 12.4 0.3 0.078 12.4 0.3 3.0 3 0 0 3 3 3 0 zinc-ribbon domain DUF2752 PF10825.8 AIC14528.1 - 0.49 10.5 5.7 1.4 9.0 0.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2752) zinc_ribbon_2 PF13240.6 AIC14528.1 - 0.54 10.0 14.9 0.57 10.0 7.6 3.1 2 1 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIC14528.1 - 0.84 9.6 6.8 0.53 10.3 1.7 2.0 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Zn_ribbon_SprT PF17283.2 AIC14528.1 - 1.8 8.5 11.4 4.3 7.3 0.3 3.3 4 0 0 4 4 4 0 SprT-like zinc ribbon domain zf-C2HC5 PF06221.13 AIC14528.1 - 2.7 8.0 9.5 1.4 9.0 0.3 2.6 1 1 1 2 2 2 0 Putative zinc finger motif, C2HC5-type Zn_Tnp_IS1595 PF12760.7 AIC14528.1 - 2.9 7.9 10.5 0.51 10.4 5.6 2.0 2 0 0 2 2 2 0 Transposase zinc-ribbon domain C1_2 PF03107.16 AIC14528.1 - 3.2 8.2 10.9 4.2 7.8 5.2 2.1 1 1 1 2 2 2 0 C1 domain A2L_zn_ribbon PF08792.10 AIC14528.1 - 6.7 6.6 10.4 29 4.5 5.3 3.0 2 1 0 2 2 2 0 A2L zinc ribbon domain Auto_anti-p27 PF06677.12 AIC14528.1 - 7.3 6.8 14.5 0.29 11.3 6.4 2.2 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) EF1_GNE PF00736.19 AIC14529.1 - 2.9e-14 53.0 0.1 3.2e-14 52.9 0.1 1.0 1 0 0 1 1 1 1 EF-1 guanine nucleotide exchange domain AAA PF00004.29 AIC14530.1 - 1.3e-91 303.9 0.0 4.2e-48 163.1 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AIC14530.1 - 2.1e-32 110.7 0.8 9.3e-16 57.4 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AIC14530.1 - 1.5e-27 95.6 1.1 3.9e-27 94.3 0.3 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 AIC14530.1 - 5.4e-14 52.7 0.0 2.8e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AIC14530.1 - 1.9e-13 50.4 0.0 1.3e-07 31.5 0.0 2.9 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIC14530.1 - 4.8e-12 46.6 0.9 0.0011 19.4 0.1 4.8 2 2 0 2 2 2 2 AAA ATPase domain AAA_5 PF07728.14 AIC14530.1 - 1.2e-11 44.8 0.4 3.9e-05 23.7 0.0 4.4 3 3 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIC14530.1 - 2.5e-10 40.5 0.0 1.4e-05 25.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AIC14530.1 - 4.1e-10 40.1 0.5 0.029 14.6 0.1 4.4 2 2 1 3 3 3 2 AAA domain AAA_33 PF13671.6 AIC14530.1 - 1.3e-09 38.3 0.0 8.8e-05 22.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AIC14530.1 - 3.5e-08 33.0 0.2 0.006 15.8 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain IstB_IS21 PF01695.17 AIC14530.1 - 1.1e-07 31.7 0.0 0.01 15.6 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.6 AIC14530.1 - 1.2e-07 31.5 0.2 1.2 8.7 0.0 4.4 4 0 0 4 4 4 2 AAA domain RNA_helicase PF00910.22 AIC14530.1 - 1.7e-07 31.6 0.0 0.014 15.8 0.0 2.6 2 0 0 2 2 2 2 RNA helicase AAA_28 PF13521.6 AIC14530.1 - 4.5e-07 30.3 0.0 0.008 16.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 AIC14530.1 - 5.7e-07 30.1 0.0 0.011 16.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 AIC14530.1 - 1.1e-06 28.5 0.2 0.1 12.3 0.0 3.5 3 1 0 3 3 2 2 Sigma-54 interaction domain AAA_24 PF13479.6 AIC14530.1 - 1.2e-06 28.4 0.0 0.024 14.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 AIC14530.1 - 1.3e-06 28.1 0.0 0.058 12.9 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region Mg_chelatase PF01078.21 AIC14530.1 - 1.7e-06 27.6 0.7 0.0078 15.6 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ABC_tran PF00005.27 AIC14530.1 - 1.7e-06 28.6 0.0 0.022 15.3 0.0 2.7 2 0 0 2 2 2 2 ABC transporter CDC48_2 PF02933.17 AIC14530.1 - 3.6e-06 26.7 0.3 8.3e-06 25.5 0.3 1.6 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 PhoH PF02562.16 AIC14530.1 - 4.7e-06 26.2 1.9 0.22 10.9 0.0 3.4 2 1 1 3 3 3 2 PhoH-like protein ATPase PF06745.13 AIC14530.1 - 1.1e-05 25.0 0.3 0.33 10.3 0.0 3.3 2 1 1 3 3 3 2 KaiC ATPase_2 PF01637.18 AIC14530.1 - 2.5e-05 24.3 0.1 0.019 14.9 0.0 3.2 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea DUF2075 PF09848.9 AIC14530.1 - 2.8e-05 23.5 0.0 0.014 14.7 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) Sigma54_activ_2 PF14532.6 AIC14530.1 - 8.7e-05 22.7 0.0 0.2 11.8 0.0 2.4 2 0 0 2 2 2 2 Sigma-54 interaction domain Parvo_NS1 PF01057.17 AIC14530.1 - 0.00016 20.9 0.2 0.15 11.1 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 ResIII PF04851.15 AIC14530.1 - 0.00025 21.1 0.0 0.31 11.0 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AIC14530.1 - 0.00036 20.3 0.8 0.36 10.6 0.0 3.9 2 2 1 4 4 4 1 DEAD/DEAH box helicase TsaE PF02367.17 AIC14530.1 - 0.00044 20.3 0.0 0.68 9.9 0.0 2.5 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 AIC14530.1 - 0.00059 19.1 0.0 0.54 9.4 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ATP-synt_ab PF00006.25 AIC14530.1 - 0.00059 19.5 0.1 0.18 11.4 0.0 2.5 2 1 0 2 2 2 1 ATP synthase alpha/beta family, nucleotide-binding domain Rad17 PF03215.15 AIC14530.1 - 0.00089 19.2 0.5 2.2 8.2 0.0 3.6 2 2 1 3 3 3 1 Rad17 P-loop domain Bac_DnaA PF00308.18 AIC14530.1 - 0.0012 18.8 0.0 0.37 10.6 0.0 3.1 3 1 0 3 3 2 1 Bacterial dnaA protein Vps4_C PF09336.10 AIC14530.1 - 0.0013 18.7 0.0 0.17 11.9 0.0 2.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain Cytidylate_kin PF02224.18 AIC14530.1 - 0.0019 18.0 0.2 1.5 8.5 0.0 2.9 3 0 0 3 3 2 1 Cytidylate kinase AAA_6 PF12774.7 AIC14530.1 - 0.0027 16.7 0.0 1.7 7.5 0.0 2.8 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region Zeta_toxin PF06414.12 AIC14530.1 - 0.0046 16.2 0.1 3.8 6.7 0.1 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_30 PF13604.6 AIC14530.1 - 0.0054 16.5 0.1 3.1 7.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 AIC14530.1 - 0.0055 16.5 0.2 1.2 8.8 0.0 2.8 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 AIC14530.1 - 0.0057 16.6 0.3 10 6.0 0.0 3.6 3 0 0 3 3 3 0 NACHT domain AAA_3 PF07726.11 AIC14530.1 - 0.0073 16.2 0.0 0.63 9.9 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 AIC14530.1 - 0.0077 16.7 0.2 3.2 8.2 0.0 3.4 3 2 0 3 3 3 1 AAA domain TniB PF05621.11 AIC14530.1 - 0.014 14.8 0.0 8.3 5.8 0.0 3.4 4 0 0 4 4 4 0 Bacterial TniB protein Guanylate_kin PF00625.21 AIC14530.1 - 0.016 14.9 0.4 49 3.5 0.0 4.1 2 2 2 4 4 4 0 Guanylate kinase IPT PF01745.16 AIC14530.1 - 0.017 14.6 0.2 1.1 8.6 0.1 2.4 2 0 0 2 2 2 0 Isopentenyl transferase T2SSE PF00437.20 AIC14530.1 - 0.029 13.4 0.0 4.7 6.2 0.0 2.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 AIC14530.1 - 0.039 13.7 0.3 2.7 7.8 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_21 PF13304.6 AIC14530.1 - 0.042 13.6 0.4 5.6 6.7 0.1 2.5 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_19 PF13245.6 AIC14530.1 - 0.061 13.7 1.1 7.4 6.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain SKI PF01202.22 AIC14530.1 - 0.082 13.0 0.2 19 5.4 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase SRPRB PF09439.10 AIC14530.1 - 0.096 12.1 0.0 22 4.4 0.0 2.8 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit Disulph_isomer PF06491.11 AIC14530.1 - 0.14 12.2 0.0 26 4.9 0.0 2.6 2 0 0 2 2 2 0 Disulphide isomerase NB-ARC PF00931.22 AIC14530.1 - 0.19 10.9 0.1 10 5.2 0.0 2.3 2 0 0 2 2 2 0 NB-ARC domain AAA_23 PF13476.6 AIC14530.1 - 0.27 11.7 0.7 16 5.9 0.2 2.7 2 0 0 2 2 2 0 AAA domain DUF1456 PF07308.13 AIC14531.1 - 0.0074 16.6 0.1 0.0093 16.3 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1456) UbiA PF01040.18 AIC14532.1 - 9.1e-52 175.8 26.6 1.3e-51 175.4 26.6 1.3 1 0 0 1 1 1 1 UbiA prenyltransferase family Copper-bind PF00127.20 AIC14534.1 - 1.6e-17 63.7 2.5 7.3e-08 32.8 0.3 2.7 2 1 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC14534.1 - 2.6e-12 46.8 0.0 4.5e-06 26.7 0.0 2.5 2 1 0 2 2 2 2 Cupredoxin-like domain Prok-JAB PF14464.6 AIC14535.1 - 3.1e-16 59.2 0.0 3.6e-16 59.0 0.0 1.0 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain tRNA-synt_2 PF00152.20 AIC14536.1 - 2e-82 276.8 0.0 2.8e-82 276.3 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AIC14536.1 - 8.3e-10 38.5 0.5 1.6e-09 37.6 0.5 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AIC14536.1 - 0.00034 20.2 0.2 0.066 12.7 0.0 2.4 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) KH_5 PF13184.6 AIC14537.1 - 0.00087 19.3 0.1 0.0025 17.9 0.0 1.8 2 0 0 2 2 2 1 NusA-like KH domain zf-RING_9 PF13901.6 AIC14537.1 - 0.12 12.3 0.2 0.24 11.4 0.2 1.5 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon ABC_tran PF00005.27 AIC14539.1 - 4.3e-25 88.8 0.0 6.6e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 AIC14539.1 - 1e-21 77.2 0.2 1.7e-21 76.5 0.2 1.4 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_21 PF13304.6 AIC14539.1 - 7.7e-09 35.8 0.4 7.3e-06 26.0 0.5 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIC14539.1 - 0.0046 16.4 0.4 0.033 13.6 0.1 2.1 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 AIC14539.1 - 0.02 13.7 1.0 1 8.1 0.2 2.5 2 1 0 2 2 2 0 Predicted ATPase of the ABC class TniB PF05621.11 AIC14539.1 - 0.022 14.2 0.2 1.5 8.2 0.1 2.2 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 AIC14539.1 - 0.036 14.5 0.1 0.052 13.9 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 AIC14539.1 - 0.085 12.4 0.3 13 5.3 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 AIC14539.1 - 0.11 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 AIC14539.1 - 0.18 12.1 1.1 4 7.7 1.1 2.1 1 1 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.6 AIC14540.1 - 7.5e-20 71.8 0.1 2.1e-19 70.3 0.0 1.8 2 0 0 2 2 2 1 Helicase C-terminal domain ResIII PF04851.15 AIC14540.1 - 1.1e-06 28.7 4.2 2.7e-06 27.5 0.1 3.2 2 2 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 AIC14540.1 - 2.5e-06 27.2 0.0 4.5e-06 26.4 0.0 1.4 1 0 0 1 1 1 1 DEAD_2 DEAD PF00270.29 AIC14540.1 - 1.9e-05 24.5 0.1 0.18 11.6 0.0 2.9 3 0 0 3 3 3 2 DEAD/DEAH box helicase RuvB_N PF05496.12 AIC14540.1 - 0.13 12.0 0.0 0.98 9.2 0.0 2.3 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain Gram_pos_anchor PF00746.21 AIC14541.1 - 3.8 7.5 5.7 29 4.7 0.4 3.4 3 0 0 3 3 3 0 LPXTG cell wall anchor motif IMS PF00817.20 AIC14542.1 - 1.3e-41 142.1 0.7 7.1e-41 139.7 0.1 2.1 2 0 0 2 2 2 1 impB/mucB/samB family IMS_C PF11799.8 AIC14542.1 - 1e-07 32.6 0.2 2e-07 31.7 0.2 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 AIC14542.1 - 2.2e-06 27.6 0.0 5.9e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 IMS family HHH motif HHH_5 PF14520.6 AIC14542.1 - 1e-05 26.0 0.1 3.3e-05 24.4 0.1 1.9 1 0 0 1 1 1 1 Helix-hairpin-helix domain Cdd1 PF11731.8 AIC14542.1 - 0.0022 18.2 0.0 0.021 15.0 0.0 2.5 3 0 0 3 3 3 1 Pathogenicity locus HHH PF00633.23 AIC14542.1 - 0.036 13.9 0.5 0.18 11.7 0.0 2.4 2 1 1 3 3 3 0 Helix-hairpin-helix motif HHH_8 PF14716.6 AIC14542.1 - 0.06 13.7 0.0 1.5 9.3 0.0 2.9 3 0 0 3 3 3 0 Helix-hairpin-helix domain PGK PF00162.19 AIC14543.1 - 2.4e-135 451.4 0.1 2.8e-135 451.1 0.1 1.0 1 0 0 1 1 1 1 Phosphoglycerate kinase DUF929 PF06053.11 AIC14544.1 - 1.6e-23 83.4 0.0 3.5e-23 82.2 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF929) Ribosomal_L16 PF00252.18 AIC14545.1 - 2.8e-29 101.8 0.2 3.6e-29 101.4 0.2 1.0 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e tRNA_int_endo PF01974.17 AIC14546.1 - 1.1e-19 70.3 1.6 1.2e-19 70.2 0.3 1.6 2 0 0 2 2 2 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 AIC14546.1 - 1.1e-06 28.2 0.2 2e-06 27.3 0.2 1.5 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain tRNA_int_end_N2 PF12928.7 AIC14546.1 - 0.13 12.5 0.1 0.47 10.7 0.1 1.9 2 0 0 2 2 2 0 tRNA-splicing endonuclease subunit sen54 N-term CreA PF05981.12 AIC14547.1 - 0.026 14.5 0.0 0.026 14.5 0.0 1.0 1 0 0 1 1 1 0 CreA protein CxC5 PF18718.1 AIC14549.1 - 0.028 14.5 2.6 0.028 14.5 2.6 1.3 1 1 0 1 1 1 0 CxC5 like cysteine cluster associated with KDZ transposases Opy2 PF09463.10 AIC14549.1 - 0.057 13.7 2.0 0.057 13.7 2.0 1.8 2 0 0 2 2 2 0 Opy2 protein DZR PF12773.7 AIC14549.1 - 0.2 11.7 8.8 2.8 8.0 8.8 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC14551.1 - 0.029 13.8 0.3 0.043 13.2 0.3 1.3 1 0 0 1 1 1 0 zinc-ribbon domain DNA_ligase_ZBD PF03119.16 AIC14551.1 - 0.032 14.3 0.1 0.032 14.3 0.1 1.2 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain TF_Zn_Ribbon PF08271.12 AIC14551.1 - 0.07 12.7 0.2 0.11 12.1 0.2 1.3 1 0 0 1 1 1 0 TFIIB zinc-binding zf-ACC PF17848.1 AIC14551.1 - 0.071 13.2 0.1 0.098 12.7 0.1 1.2 1 0 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain TRAM PF01938.20 AIC14554.1 - 1.7e-13 50.4 1.9 2.3e-13 49.9 1.9 1.2 1 0 0 1 1 1 1 TRAM domain zf-C2H2_6 PF13912.6 AIC14555.1 - 0.023 14.7 0.1 0.028 14.4 0.1 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC14555.1 - 0.036 14.5 0.3 0.049 14.1 0.3 1.2 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 AIC14555.1 - 0.044 14.1 0.1 0.047 14.0 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_4 PF13894.6 AIC14555.1 - 0.067 14.1 0.3 0.091 13.6 0.3 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger CBS PF00571.28 AIC14556.1 - 2e-19 69.7 2.2 4.5e-12 46.2 0.1 2.1 2 0 0 2 2 2 2 CBS domain zinc_ribbon_2 PF13240.6 AIC14557.1 - 3.4e-06 26.6 2.6 3.4e-06 26.6 2.6 2.0 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.7 AIC14557.1 - 0.00019 21.4 1.9 0.00026 20.9 1.1 1.6 2 0 0 2 2 2 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC14557.1 - 0.0057 16.0 3.9 0.0057 16.0 3.9 2.1 2 0 0 2 2 2 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIC14557.1 - 0.037 14.8 0.2 0.078 13.7 0.2 1.5 1 0 0 1 1 1 0 zinc-ribbon family zf-RanBP PF00641.18 AIC14557.1 - 0.13 11.6 4.7 0.25 10.7 4.7 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DUF35_N PF12172.8 AIC14557.1 - 0.14 12.0 0.5 0.36 10.7 0.5 1.6 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-B_box PF00643.24 AIC14557.1 - 0.15 12.3 0.8 0.22 11.7 0.8 1.3 1 0 0 1 1 1 0 B-box zinc finger Nudix_N_2 PF14803.6 AIC14557.1 - 1.4 8.9 3.1 3 7.9 0.1 2.6 2 0 0 2 2 2 0 Nudix N-terminal MMR_HSR1_Xtn PF16897.5 AIC14558.1 - 9.9e-28 96.3 0.4 2e-27 95.3 0.4 1.5 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 AIC14558.1 - 3e-22 78.4 0.0 6.5e-22 77.4 0.0 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 AIC14558.1 - 3e-22 78.9 0.0 6.5e-22 77.8 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 AIC14558.1 - 9.6e-15 54.4 0.2 7.1e-13 48.4 0.0 2.3 2 0 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AIC14558.1 - 6.3e-07 29.5 0.4 0.012 15.5 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase Arf PF00025.21 AIC14558.1 - 0.00011 21.7 0.2 0.036 13.5 0.0 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family AIG1 PF04548.16 AIC14558.1 - 0.00097 18.5 0.1 0.0037 16.6 0.0 2.0 2 0 0 2 2 2 1 AIG1 family Ras PF00071.22 AIC14558.1 - 0.001 18.7 0.0 0.22 11.1 0.0 2.4 2 0 0 2 2 2 1 Ras family SRPRB PF09439.10 AIC14558.1 - 0.0013 18.2 0.2 0.0034 16.8 0.0 1.7 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Dynamin_N PF00350.23 AIC14558.1 - 0.0032 17.6 0.1 0.3 11.1 0.1 2.6 2 0 0 2 2 2 1 Dynamin family cobW PF02492.19 AIC14558.1 - 0.0042 16.7 0.2 1.1 8.8 0.0 2.4 2 0 0 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 AIC14558.1 - 0.0085 16.3 0.1 0.018 15.3 0.1 1.5 1 0 0 1 1 1 1 AAA domain Roc PF08477.13 AIC14558.1 - 0.015 15.5 0.0 0.04 14.1 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 AIC14558.1 - 0.044 14.2 0.1 0.093 13.1 0.0 1.6 2 0 0 2 2 1 0 AAA ATPase domain MCM PF00493.23 AIC14558.1 - 0.055 12.6 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_22 PF13401.6 AIC14558.1 - 0.068 13.5 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 AAA domain MeaB PF03308.16 AIC14558.1 - 0.072 12.1 0.0 0.14 11.1 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 AIC14558.1 - 0.11 12.6 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Cupredoxin_1 PF13473.6 AIC14559.1 - 2e-09 37.5 0.0 2.2e-09 37.3 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIC14559.1 - 0.018 15.5 0.6 0.037 14.5 0.6 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family HCV_NS4a PF01006.20 AIC14559.1 - 0.99 9.2 3.7 1.8 8.4 3.7 1.6 1 1 0 1 1 1 0 Hepatitis C virus non-structural protein NS4a TRAM PF01938.20 AIC14560.1 - 1.2e-12 47.6 1.2 1.4e-12 47.4 1.2 1.1 1 0 0 1 1 1 1 TRAM domain DUF108 PF01958.18 AIC14561.1 - 1.9e-35 121.1 0.7 3.9e-35 120.1 0.7 1.6 1 0 0 1 1 1 1 Domain of unknown function DUF108 NAD_binding_3 PF03447.16 AIC14561.1 - 2e-23 83.3 0.3 3.1e-23 82.6 0.3 1.3 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA PF01408.22 AIC14561.1 - 3.8e-07 31.0 0.1 9e-07 29.7 0.1 1.7 1 1 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DapB_N PF01113.20 AIC14561.1 - 5.6e-05 23.3 0.1 9.3e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Semialdhyde_dh PF01118.24 AIC14561.1 - 0.00028 21.3 0.2 0.00053 20.4 0.2 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 AIC14561.1 - 0.0014 17.6 0.3 0.0021 17.1 0.3 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family F420_oxidored PF03807.17 AIC14561.1 - 0.014 15.9 0.3 0.033 14.8 0.3 1.6 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 AIC14561.1 - 0.054 12.8 1.4 0.12 11.7 1.4 1.6 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DUF3759 PF12585.8 AIC14561.1 - 0.12 12.4 0.2 0.32 11.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3759) 3HCDH_N PF02737.18 AIC14561.1 - 2.8 7.8 6.0 28 4.5 5.6 2.5 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Ribosomal_S30 PF04758.14 AIC14562.1 - 3.8e-11 43.0 5.5 4.5e-11 42.8 5.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S30 NadA PF02445.16 AIC14565.1 - 4.9e-105 351.0 6.7 5.5e-105 350.8 6.7 1.0 1 0 0 1 1 1 1 Quinolinate synthetase A protein Ribosomal_S8 PF00410.19 AIC14565.1 - 0.017 15.1 0.2 0.08 12.9 0.2 2.0 2 0 0 2 2 2 0 Ribosomal protein S8 QRPTase_C PF01729.19 AIC14566.1 - 2.1e-51 174.1 0.3 3.3e-51 173.4 0.3 1.3 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain QRPTase_N PF02749.16 AIC14566.1 - 1.8e-26 92.0 0.4 3.3e-26 91.1 0.4 1.5 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Ribul_P_3_epim PF00834.19 AIC14566.1 - 0.032 13.6 0.1 0.12 11.7 0.0 1.8 1 1 0 1 1 1 0 Ribulose-phosphate 3 epimerase family PT-HINT PF07591.11 AIC14566.1 - 0.033 14.4 0.1 0.061 13.6 0.1 1.4 1 0 0 1 1 1 0 Pretoxin HINT domain Spt4 PF06093.13 AIC14567.1 - 1.8e-12 47.2 0.2 2.2e-12 46.9 0.2 1.1 1 0 0 1 1 1 1 Spt4/RpoE2 zinc finger RecR PF02132.15 AIC14567.1 - 0.00078 19.0 0.8 0.00099 18.6 0.8 1.2 1 0 0 1 1 1 1 RecR protein TackOD1 PF18551.1 AIC14567.1 - 0.039 13.6 0.7 0.047 13.4 0.7 1.1 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 TF_Zn_Ribbon PF08271.12 AIC14567.1 - 0.049 13.2 0.7 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 TFIIB zinc-binding zf-RRN7 PF11781.8 AIC14567.1 - 0.27 10.9 0.2 0.27 10.9 0.2 2.0 1 1 1 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-ribbon_3 PF13248.6 AIC14567.1 - 0.37 10.3 4.1 1.2 8.7 0.4 2.1 1 1 1 2 2 2 0 zinc-ribbon domain SHS2_Rpb7-N PF03876.17 AIC14568.1 - 6.6e-18 64.9 0.0 5.8e-17 61.8 0.0 2.1 2 0 0 2 2 2 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 AIC14568.1 - 4e-14 52.7 0.1 1.1e-13 51.4 0.1 1.7 1 1 0 1 1 1 1 S1 RNA binding domain S1_2 PF13509.6 AIC14568.1 - 0.006 16.6 0.0 0.017 15.1 0.0 1.8 1 1 1 2 2 2 1 S1 domain ParA PF10609.9 AIC14569.1 - 3.8e-101 337.7 0.4 4.8e-101 337.3 0.4 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase FeS_assembly_P PF01883.19 AIC14569.1 - 1.9e-20 72.8 0.1 5.7e-20 71.3 0.1 1.8 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein CbiA PF01656.23 AIC14569.1 - 1.1e-14 54.5 0.0 4e-14 52.8 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AIC14569.1 - 4.9e-11 42.8 5.8 7.5e-10 39.0 1.8 2.5 2 1 1 3 3 3 1 AAA domain Fer4_NifH PF00142.18 AIC14569.1 - 1.5e-06 27.9 0.1 0.0004 19.9 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 AIC14569.1 - 1.8e-06 27.4 0.0 3.5e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 AIC14569.1 - 7.2e-06 25.4 1.3 7.2e-06 25.4 1.3 2.4 2 1 1 3 3 3 1 Anion-transporting ATPase VirC1 PF07015.11 AIC14569.1 - 0.00022 20.6 0.1 0.0004 19.8 0.1 1.3 1 0 0 1 1 1 1 VirC1 protein AAA_25 PF13481.6 AIC14569.1 - 0.00058 19.5 0.2 0.0011 18.5 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_26 PF13500.6 AIC14569.1 - 0.001 18.9 2.6 0.34 10.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain SRP54 PF00448.22 AIC14569.1 - 0.011 15.3 0.2 0.024 14.3 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 AIC14569.1 - 0.03 13.8 0.2 0.2 11.1 0.3 2.0 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsQ APS_kinase PF01583.20 AIC14569.1 - 0.059 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase CLP1_P PF16575.5 AIC14569.1 - 0.063 13.1 0.0 0.11 12.3 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF359 PF04019.12 AIC14570.1 - 4.9e-37 126.4 0.0 8.3e-37 125.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF359) HEM4 PF02602.15 AIC14570.1 - 0.053 12.9 0.1 0.25 10.6 0.1 1.8 1 1 1 2 2 2 0 Uroporphyrinogen-III synthase HemD DUF2318 PF10080.9 AIC14571.1 - 0.037 14.2 6.0 0.56 10.4 5.3 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2318) DnaJ_CXXCXGXG PF00684.19 AIC14572.1 - 0.0011 19.3 10.4 0.0029 18.0 9.9 1.9 1 1 0 1 1 1 1 DnaJ central domain zf-nanos PF05741.13 AIC14572.1 - 0.031 14.5 10.8 0.36 11.1 6.6 2.6 1 1 1 2 2 2 0 Nanos RNA binding domain YacG PF03884.14 AIC14572.1 - 0.041 13.6 10.8 0.19 11.5 1.1 2.3 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG Zn_Tnp_IS1595 PF12760.7 AIC14572.1 - 0.27 11.3 13.5 4.5 7.3 4.1 3.0 1 1 2 3 3 3 0 Transposase zinc-ribbon domain DUF5351 PF17302.2 AIC14572.1 - 0.45 10.8 9.1 3.4 7.9 0.1 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5351) Anti-TRAP PF15777.5 AIC14572.1 - 0.73 9.8 15.8 0.42 10.6 0.4 3.0 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Lar_restr_allev PF14354.6 AIC14572.1 - 0.75 10.2 17.3 4.8 7.6 2.3 3.1 1 1 2 3 3 3 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.6 AIC14572.1 - 0.88 9.1 14.0 3.2 7.3 2.5 2.5 2 1 0 2 2 2 0 zinc-ribbon domain Rad50_zn_hook PF04423.14 AIC14572.1 - 1 9.3 6.5 10 6.0 0.1 3.0 3 0 0 3 3 3 0 Rad50 zinc hook motif zf_CopZ PF18423.1 AIC14572.1 - 2.4 8.2 12.2 16 5.5 0.1 3.2 3 0 0 3 3 3 0 Zinc binding domain zf-TFIIB PF13453.6 AIC14572.1 - 4.8 6.6 14.0 0.69 9.3 1.3 3.3 3 1 0 3 3 3 0 Transcription factor zinc-finger Prok-RING_4 PF14447.6 AIC14572.1 - 5.2 7.0 18.8 8 6.4 0.8 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 FAD-oxidase_C PF02913.19 AIC14573.1 - 6.7e-52 176.6 0.3 9e-52 176.2 0.3 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 AIC14573.1 - 4.8e-35 120.3 0.2 1.3e-34 118.9 0.1 1.8 2 0 0 2 2 2 1 FAD binding domain DUF4055 PF13264.6 AIC14573.1 - 0.015 15.4 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4055) Methyltransf_25 PF13649.6 AIC14574.1 - 7e-15 55.5 0.0 1.5e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14574.1 - 8.8e-15 55.1 0.0 1.5e-14 54.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC14574.1 - 1.4e-14 54.1 0.0 1.9e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC14574.1 - 1e-12 48.2 0.0 1.6e-12 47.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC14574.1 - 1.2e-12 48.5 0.0 2.1e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC14574.1 - 3.4e-09 36.4 0.0 6.6e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_2 PF00891.18 AIC14574.1 - 4.3e-08 32.7 0.0 6.4e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain MetW PF07021.12 AIC14574.1 - 2.3e-06 27.3 0.0 3.1e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW NodS PF05401.11 AIC14574.1 - 0.00014 21.5 0.0 0.00021 21.0 0.0 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Dimerisation2 PF16864.5 AIC14574.1 - 0.00019 21.3 0.0 0.00047 20.1 0.0 1.6 1 0 0 1 1 1 1 Dimerisation domain MTS PF05175.14 AIC14574.1 - 0.00082 19.0 0.0 0.0019 17.8 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_9 PF08003.11 AIC14574.1 - 0.0038 16.2 0.0 0.0052 15.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Methyltransf_4 PF02390.17 AIC14574.1 - 0.0093 15.5 0.0 0.034 13.6 0.0 1.9 2 0 0 2 2 2 1 Putative methyltransferase PCMT PF01135.19 AIC14574.1 - 0.03 14.1 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 AIC14574.1 - 0.033 13.5 0.0 0.044 13.1 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 AIC14574.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 FtsJ-like methyltransferase Glyoxalase PF00903.25 AIC14575.1 - 9.6e-14 51.7 0.0 1.3e-13 51.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 AIC14575.1 - 3.5e-12 46.3 0.0 6e-12 45.5 0.0 1.3 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 AIC14575.1 - 0.0012 19.7 0.0 0.0015 19.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 AIC14575.1 - 0.0052 17.0 0.0 0.099 12.9 0.0 2.1 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily VIT1 PF01988.19 AIC14579.1 - 3.6e-59 200.2 2.8 4.1e-59 200.1 2.8 1.0 1 0 0 1 1 1 1 VIT family DUF123 PF01986.16 AIC14579.1 - 0.035 14.6 0.1 0.053 14.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF123 Myelin_PLP PF01275.19 AIC14579.1 - 0.28 11.0 2.8 0.47 10.3 2.0 1.7 2 0 0 2 2 2 0 Myelin proteolipid protein (PLP or lipophilin) HTH_Tnp_ISL3 PF13542.6 AIC14580.1 - 0.0099 15.3 0.1 0.015 14.7 0.1 1.4 1 1 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 DUF356 PF04009.12 AIC14580.1 - 0.043 14.1 0.1 0.044 14.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF356) HTH_23 PF13384.6 AIC14580.1 - 0.046 13.5 0.1 0.058 13.2 0.1 1.1 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 AIC14580.1 - 0.063 13.0 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-70, region 4 DUF2316 PF10078.9 AIC14580.1 - 0.097 12.9 0.0 0.1 12.9 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) TnsD PF15978.5 AIC14580.1 - 0.12 11.4 0.1 0.12 11.4 0.1 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D COX1 PF00115.20 AIC14581.1 - 8.2e-05 21.6 16.0 8.2e-05 21.6 16.0 2.0 1 1 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I DUF4271 PF14093.6 AIC14581.1 - 0.015 15.2 1.1 0.025 14.5 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) DUF2207 PF09972.9 AIC14581.1 - 7.2 5.2 14.0 0.28 9.9 7.4 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) HSP20 PF00011.21 AIC14583.1 - 1.1e-22 80.1 4.0 1.6e-22 79.5 4.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AIC14583.1 - 3.3e-07 29.8 0.0 5.7e-07 29.0 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA P-II PF00543.22 AIC14585.1 - 1.8e-13 51.0 0.0 2e-13 50.8 0.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II CBS PF00571.28 AIC14587.1 - 3.5e-24 85.0 1.1 1.1e-12 48.2 0.0 2.1 2 0 0 2 2 2 2 CBS domain Ribosomal_L9_C PF03948.14 AIC14587.1 - 0.052 14.0 1.3 4.8 7.7 0.1 2.3 1 1 1 2 2 2 0 Ribosomal protein L9, C-terminal domain Antimicrobial20 PF08256.11 AIC14587.1 - 1.6 9.5 4.5 50 4.9 0.1 3.2 2 0 0 2 2 2 0 Aurein-like antibiotic peptide Usp PF00582.26 AIC14589.1 - 7.1e-29 101.1 0.2 8.4e-29 100.9 0.2 1.1 1 0 0 1 1 1 1 Universal stress protein family DUF900 PF05990.12 AIC14589.1 - 0.11 12.0 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) SnoaL_2 PF12680.7 AIC14590.1 - 6.8e-05 23.4 0.0 0.0001 22.9 0.0 1.4 1 1 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIC14590.1 - 0.0006 20.2 0.0 0.00073 19.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.6 AIC14590.1 - 0.019 15.1 0.1 0.073 13.2 0.1 1.8 1 1 0 1 1 1 0 SnoaL-like domain CaMKII_AD PF08332.10 AIC14590.1 - 0.05 13.7 0.0 0.065 13.4 0.0 1.2 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain NTF2 PF02136.20 AIC14590.1 - 0.057 14.0 0.0 0.085 13.4 0.0 1.3 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain CopG_antitoxin PF12441.8 AIC14591.1 - 0.00034 21.1 0.1 0.0025 18.3 0.0 2.3 2 0 0 2 2 2 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIC14591.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 HicB family Usp PF00582.26 AIC14592.1 - 4.4e-30 105.0 0.7 5.4e-30 104.8 0.7 1.1 1 0 0 1 1 1 1 Universal stress protein family CBS PF00571.28 AIC14593.1 - 1.9e-20 73.0 2.4 5e-11 42.9 0.2 2.2 2 0 0 2 2 2 2 CBS domain zf-C2H2_4 PF13894.6 AIC14593.1 - 0.00022 21.8 0.2 0.00045 20.8 0.2 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-Di19 PF05605.12 AIC14593.1 - 0.00032 20.9 0.0 0.00057 20.1 0.0 1.4 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 AIC14593.1 - 0.0013 19.1 0.2 0.0093 16.4 0.2 2.2 2 0 0 2 2 2 1 Zinc finger, C2H2 type RuvX PF03652.15 AIC14593.1 - 0.046 14.1 0.1 0.076 13.4 0.1 1.4 1 1 0 1 1 1 0 Holliday junction resolvase zinc_ribbon_9 PF14369.6 AIC14593.1 - 0.059 13.6 0.2 0.1 12.9 0.2 1.3 1 0 0 1 1 1 0 zinc-ribbon Cys_rich_CPXG PF14255.6 AIC14593.1 - 0.074 13.0 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Cysteine-rich CPXCG zf-C2H2_9 PF16293.5 AIC14593.1 - 0.14 12.0 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) CBS PF00571.28 AIC14594.1 - 4.4e-28 97.5 3.6 1.7e-15 57.2 0.2 2.2 2 0 0 2 2 2 2 CBS domain ChapFlgA PF13144.6 AIC14594.1 - 0.00049 20.1 0.5 0.00074 19.6 0.5 1.3 1 0 0 1 1 1 1 Chaperone for flagella basal body P-ring formation LAMTOR5 PF16672.5 AIC14594.1 - 0.0018 18.2 0.1 0.004 17.1 0.1 1.7 1 1 0 1 1 1 1 Ragulator complex protein LAMTOR5 NIR_SIR_ferr PF03460.17 AIC14594.1 - 0.17 11.7 0.2 0.67 9.9 0.0 2.0 2 1 0 2 2 2 0 Nitrite/Sulfite reductase ferredoxin-like half domain Usp PF00582.26 AIC14595.1 - 5.9e-24 85.2 0.1 6.2e-24 85.1 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family AA_permease_2 PF13520.6 AIC14596.1 - 2.9e-53 181.2 59.6 3.5e-53 181.0 59.6 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AIC14596.1 - 1e-33 116.7 55.8 1.3e-33 116.4 55.8 1.0 1 0 0 1 1 1 1 Amino acid permease Spore_permease PF03845.13 AIC14596.1 - 0.14 10.9 33.6 0.49 9.2 22.8 2.8 1 1 1 2 2 2 0 Spore germination protein Sigma70_ECF PF07638.11 AIC14598.1 - 2.4e-05 24.3 0.0 2.6e-05 24.2 0.0 1.0 1 0 0 1 1 1 1 ECF sigma factor HTH_23 PF13384.6 AIC14598.1 - 9.1e-05 22.1 0.1 0.00011 21.8 0.1 1.1 1 0 0 1 1 1 1 Homeodomain-like domain HTH_7 PF02796.15 AIC14598.1 - 0.00019 21.4 0.0 0.00021 21.3 0.0 1.1 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase Sigma70_r4_2 PF08281.12 AIC14598.1 - 0.00027 20.5 0.0 0.00036 20.1 0.0 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_Tnp_ISL3 PF13542.6 AIC14598.1 - 0.0013 18.1 0.0 0.0022 17.4 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 GerE PF00196.19 AIC14598.1 - 0.0014 18.1 0.0 0.0019 17.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family Sigma70_r4 PF04545.16 AIC14598.1 - 0.0065 16.0 0.1 0.0084 15.6 0.1 1.2 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_24 PF13412.6 AIC14598.1 - 0.02 14.4 0.1 0.029 13.9 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding TnsD PF15978.5 AIC14598.1 - 0.032 13.2 0.0 0.032 13.2 0.0 1.0 1 0 0 1 1 1 0 Tn7-like transposition protein D HTH_28 PF13518.6 AIC14598.1 - 0.052 13.7 0.0 0.062 13.4 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain Rrf2 PF02082.20 AIC14598.1 - 0.06 13.7 0.0 0.066 13.6 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator HTH_38 PF13936.6 AIC14598.1 - 0.09 12.6 0.3 0.12 12.1 0.3 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_6 PF01418.17 AIC14598.1 - 0.11 12.5 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family DUF2316 PF10078.9 AIC14598.1 - 0.18 12.1 0.0 0.56 10.5 0.0 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) CBS PF00571.28 AIC14599.1 - 6.2e-16 58.6 0.1 9.4e-05 22.8 0.0 3.6 3 0 0 3 3 3 3 CBS domain ADH_N PF08240.12 AIC14600.1 - 1.2e-27 96.0 0.1 2.2e-27 95.1 0.1 1.5 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIC14600.1 - 1.7e-27 96.0 0.1 3.2e-27 95.1 0.1 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIC14600.1 - 1.7e-16 61.4 0.0 3.5e-16 60.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AIC14600.1 - 0.00048 19.7 0.2 0.00074 19.1 0.2 1.2 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus TrkA_N PF02254.18 AIC14600.1 - 0.012 15.8 0.1 0.021 15.1 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Methyltransf_31 PF13847.6 AIC14600.1 - 0.025 14.4 0.1 0.32 10.8 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain Usp PF00582.26 AIC14602.1 - 5.5e-15 56.1 0.5 5.6e-15 56.1 0.5 1.0 1 0 0 1 1 1 1 Universal stress protein family SRP54 PF00448.22 AIC14602.1 - 0.012 15.2 0.1 0.012 15.2 0.1 1.0 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Usp PF00582.26 AIC14603.1 - 4e-08 33.9 0.0 4.3e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family CBS PF00571.28 AIC14604.1 - 6e-39 132.3 4.3 4.6e-10 39.8 0.1 4.1 4 0 0 4 4 4 4 CBS domain Usp PF00582.26 AIC14605.1 - 1.2e-25 90.7 0.5 1.6e-24 87.0 0.5 2.1 1 1 0 1 1 1 1 Universal stress protein family DXP_reductoisom PF02670.16 AIC14605.1 - 0.04 14.6 0.0 0.057 14.1 0.0 1.2 1 0 0 1 1 1 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase Usp PF00582.26 AIC14606.1 - 3.7e-30 105.3 0.0 6e-30 104.6 0.0 1.3 1 0 0 1 1 1 1 Universal stress protein family INCENP_N PF12178.8 AIC14606.1 - 0.037 14.0 0.1 0.068 13.2 0.1 1.4 1 0 0 1 1 1 0 Chromosome passenger complex (CPC) protein INCENP N terminal Phage_holin_3_6 PF07332.11 AIC14607.1 - 0.0026 17.8 4.1 0.0031 17.5 4.1 1.0 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF202 PF02656.15 AIC14607.1 - 0.84 10.1 8.4 5 7.6 8.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF202) DUF3143 PF11341.8 AIC14608.1 - 0.0058 17.0 0.0 0.0096 16.3 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3143) RDD PF06271.12 AIC14609.1 - 2.9e-13 50.2 4.3 4.8e-13 49.5 4.3 1.4 1 1 0 1 1 1 1 RDD family DUF4705 PF15788.5 AIC14609.1 - 0.089 13.0 0.1 0.16 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4705) DUF4232 PF14016.6 AIC14610.1 - 0.0018 18.4 0.0 0.0034 17.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4232) DUF2371 PF10177.9 AIC14610.1 - 0.085 13.0 1.1 11 6.2 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) Filamin PF00630.19 AIC14610.1 - 0.11 13.3 0.0 0.17 12.7 0.0 1.3 1 0 0 1 1 1 0 Filamin/ABP280 repeat CarboxypepD_reg PF13620.6 AIC14610.1 - 0.11 12.7 5.0 1.6 9.1 1.2 3.2 2 1 0 2 2 2 0 Carboxypeptidase regulatory-like domain EMP24_GP25L PF01105.24 AIC14610.1 - 0.2 11.6 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Big_3 PF07523.12 AIC14610.1 - 0.24 11.7 2.6 0.24 11.7 0.2 2.2 3 0 0 3 3 3 0 Bacterial Ig-like domain (group 3) DUF3040 PF11239.8 AIC14610.1 - 2.2 8.6 12.3 0.74 10.1 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Flavodoxin_1 PF00258.25 AIC14611.1 - 1.9e-09 37.9 0.2 3.3e-09 37.1 0.2 1.6 1 1 0 1 1 1 1 Flavodoxin Flavodoxin_3 PF12641.7 AIC14611.1 - 8.5e-07 28.8 0.0 1.3e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Flavodoxin domain Flavodoxin_5 PF12724.7 AIC14611.1 - 9.9e-07 29.1 0.0 1.5e-06 28.5 0.0 1.3 1 1 0 1 1 1 1 Flavodoxin domain FMN_red PF03358.15 AIC14611.1 - 0.0015 18.3 0.0 0.34 10.7 0.0 2.2 1 1 1 2 2 2 2 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AIC14611.1 - 0.0018 18.0 0.0 0.0072 16.0 0.0 1.9 1 1 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_4 PF12682.7 AIC14611.1 - 0.06 13.1 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 Flavodoxin PTS_IIB PF02302.17 AIC14611.1 - 0.076 13.7 0.6 0.57 10.9 0.1 2.2 2 1 0 2 2 2 0 PTS system, Lactose/Cellobiose specific IIB subunit DUF5337 PF17272.2 AIC14612.1 - 0.21 11.4 3.0 0.72 9.7 0.3 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5337) ABC_membrane_3 PF13748.6 AIC14612.1 - 1.5 8.0 4.2 0.25 10.6 0.7 1.5 2 0 0 2 2 2 0 ABC transporter transmembrane region Cupredoxin_1 PF13473.6 AIC14613.1 - 0.0006 19.9 0.0 0.0021 18.1 0.0 1.7 1 1 1 2 2 2 1 Cupredoxin-like domain Methyltransf_31 PF13847.6 AIC14615.1 - 1.1e-16 61.0 0.0 1.8e-16 60.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC14615.1 - 1.3e-15 57.8 0.0 2.5e-15 57.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14615.1 - 1.5e-15 57.6 0.0 2.8e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC14615.1 - 5.3e-10 39.4 0.0 8.3e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC14615.1 - 2.5e-09 36.8 0.0 9.2e-08 31.7 0.0 2.2 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 AIC14615.1 - 7.3e-09 36.3 0.0 1.5e-08 35.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIC14615.1 - 0.0011 18.5 0.0 0.0024 17.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 AIC14615.1 - 0.014 14.8 0.0 0.025 14.0 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 AIC14615.1 - 0.038 13.6 0.1 0.075 12.7 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PCMT PF01135.19 AIC14615.1 - 0.082 12.6 0.1 0.22 11.2 0.0 1.8 2 1 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-C2H2 PF00096.26 AIC14616.1 - 9e-05 22.7 0.3 9e-05 22.7 0.3 2.0 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC14616.1 - 0.00018 22.0 0.2 0.00018 22.0 0.2 2.1 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 AIC14616.1 - 0.00028 20.8 0.1 0.00028 20.8 0.1 2.1 3 0 0 3 3 3 1 C2H2-type zinc finger Actin_micro PF17003.5 AIC14616.1 - 0.28 10.3 1.4 0.25 10.5 1.4 1.0 1 0 0 1 1 1 0 Putative actin-like family Phage_holin_3_6 PF07332.11 AIC14618.1 - 0.012 15.7 1.7 0.015 15.3 1.7 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Saf_2TM PF18303.1 AIC14618.1 - 0.015 14.9 0.3 0.017 14.7 0.3 1.0 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Trp_oprn_chp PF09534.10 AIC14618.1 - 0.067 13.0 0.9 0.1 12.4 0.9 1.3 1 1 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) DUF2157 PF09925.9 AIC14618.1 - 0.091 12.5 4.8 0.14 11.9 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) DUF2207 PF09972.9 AIC14618.1 - 0.16 10.7 0.3 0.18 10.5 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 AIC14618.1 - 0.17 12.7 0.7 7.4 7.5 0.1 2.0 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain FeoB_associated PF12669.7 AIC14618.1 - 0.19 12.2 0.9 21 5.6 0.1 2.2 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein DUF202 PF02656.15 AIC14618.1 - 1.4 9.4 5.2 4.1 7.9 5.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Putative_PNPOx PF01243.20 AIC14619.1 - 9.6e-19 67.4 0.0 1.3e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIC14619.1 - 3.2e-12 46.6 0.0 3.9e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIC14619.1 - 0.00028 20.5 0.0 0.00032 20.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like MtrA PF04208.14 AIC14620.1 - 1.7e-25 89.6 0.0 2.2e-25 89.3 0.0 1.0 1 0 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit A dUTPase_2 PF08761.11 AIC14621.1 - 7.9e-18 65.2 2.3 1.1e-12 48.5 0.1 2.0 1 1 1 2 2 2 2 dUTPase PRA-PH PF01503.17 AIC14621.1 - 0.0049 17.3 0.0 0.0058 17.0 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl-ATP pyrophosphohydrolase DUF550 PF04447.12 AIC14621.1 - 0.025 14.7 0.1 0.06 13.5 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF550) OMS28_porin PF03532.13 AIC14622.1 - 0.00081 18.7 0.0 0.0013 18.0 0.0 1.2 1 0 0 1 1 1 1 OMS28 porin SR-25 PF10500.9 AIC14622.1 - 0.13 11.9 6.3 0.2 11.3 6.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 AIC14622.1 - 1.1 7.6 3.6 1.6 7.0 3.6 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Glycos_transf_2 PF00535.26 AIC14623.1 - 1.3e-36 126.0 0.0 1.8e-36 125.5 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 GtrA PF04138.14 AIC14623.1 - 7.1e-22 77.9 12.5 9.4e-14 51.7 8.7 2.3 1 1 1 2 2 2 2 GtrA-like protein Glyco_tranf_2_3 PF13641.6 AIC14623.1 - 6.8e-14 52.3 0.0 1.3e-13 51.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 NTP_transf_3 PF12804.7 AIC14623.1 - 8.3e-06 26.2 0.0 1.3e-05 25.6 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain Glyco_transf_21 PF13506.6 AIC14623.1 - 0.0039 16.7 0.0 0.0075 15.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Rad51 PF08423.11 AIC14624.1 - 2.8e-30 105.4 0.0 3.3e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AIC14624.1 - 1.4e-07 31.3 0.1 2e-07 30.8 0.1 1.4 1 1 0 1 1 1 1 recA bacterial DNA recombination protein AAA_25 PF13481.6 AIC14624.1 - 2e-06 27.5 1.4 2.4e-05 24.0 1.4 2.1 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 AIC14624.1 - 1.3e-05 24.7 0.3 5.8e-05 22.6 0.1 1.9 1 1 0 2 2 2 1 KaiC AAA_24 PF13479.6 AIC14624.1 - 0.0004 20.2 0.0 0.00057 19.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC14624.1 - 0.00056 20.3 0.0 0.00071 20.0 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain CbiA PF01656.23 AIC14624.1 - 0.0046 17.0 0.0 0.0068 16.5 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 AIC14624.1 - 0.01 16.1 0.1 0.027 14.7 0.1 1.7 2 1 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 AIC14624.1 - 0.031 14.0 0.1 0.083 12.6 0.1 1.7 1 1 1 2 2 2 0 IstB-like ATP binding protein ATPase_2 PF01637.18 AIC14624.1 - 0.04 13.8 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 AIC14624.1 - 0.06 13.7 0.0 0.19 12.1 0.0 1.8 2 0 0 2 2 2 0 RNA helicase CLP1_P PF16575.5 AIC14624.1 - 0.066 13.0 0.0 0.15 11.8 0.0 1.6 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Zot PF05707.12 AIC14624.1 - 0.1 12.2 0.0 0.12 12.1 0.0 1.1 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) ICAP-1_inte_bdg PF10480.9 AIC14624.1 - 0.14 12.1 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Beta-1 integrin binding protein ABC_tran PF00005.27 AIC14624.1 - 0.19 12.2 0.1 0.44 11.1 0.1 1.5 1 1 0 1 1 1 0 ABC transporter LSM PF01423.22 AIC14625.1 - 7.4e-19 67.2 1.1 8.3e-19 67.1 1.1 1.0 1 0 0 1 1 1 1 LSM domain S-AdoMet_synt_C PF02773.16 AIC14626.1 - 6.9e-69 230.2 0.3 1.2e-68 229.4 0.0 1.5 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 AIC14626.1 - 7.5e-46 155.3 0.0 2.1e-45 153.8 0.0 1.8 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 AIC14626.1 - 3.7e-43 146.2 0.1 9.8e-43 144.9 0.0 1.7 2 0 0 2 2 2 1 S-adenosylmethionine synthetase, N-terminal domain AdoMet_Synthase PF01941.19 AIC14626.1 - 0.084 11.6 0.2 1.5 7.6 0.1 2.4 2 1 1 3 3 3 0 S-adenosylmethionine synthetase (AdoMet synthetase) adh_short_C2 PF13561.6 AIC14627.1 - 1e-55 188.9 2.3 1.2e-55 188.7 2.3 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AIC14627.1 - 3.3e-48 163.8 0.3 4.2e-48 163.4 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AIC14627.1 - 6.3e-12 45.8 0.0 1.3e-11 44.8 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 AIC14627.1 - 0.00012 21.6 0.4 0.0014 18.1 0.0 2.4 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family RmlD_sub_bind PF04321.17 AIC14627.1 - 0.0018 17.4 0.0 0.003 16.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain Sacchrp_dh_NADP PF03435.18 AIC14627.1 - 0.0094 16.2 0.0 0.02 15.2 0.0 1.5 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 AIC14627.1 - 0.019 15.6 0.0 0.045 14.3 0.0 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Glyco_transf_4 PF13439.6 AIC14627.1 - 0.097 12.7 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 THF_DHG_CYH_C PF02882.19 AIC14627.1 - 0.098 12.0 0.1 0.29 10.4 0.0 1.8 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain CbiD PF01888.17 AIC14628.1 - 7.1e-90 300.7 5.0 8.9e-90 300.4 5.0 1.1 1 0 0 1 1 1 1 CbiD HTH_AsnC-type PF13404.6 AIC14629.1 - 3.2e-14 52.5 0.1 7.3e-14 51.3 0.0 1.6 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIC14629.1 - 2.6e-12 46.1 0.1 3.9e-12 45.5 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding Arc_trans_TRASH PF08394.10 AIC14629.1 - 7.8e-06 26.1 3.1 1.4e-05 25.4 3.1 1.4 1 0 0 1 1 1 1 Archaeal TRASH domain TrmB PF01978.19 AIC14629.1 - 1.3e-05 25.0 0.1 9.5e-05 22.2 0.1 2.0 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_Tnp_ISL3 PF13542.6 AIC14629.1 - 0.00012 21.4 0.0 0.00018 20.8 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain of transposase family ISL3 DUF2089 PF09862.9 AIC14629.1 - 0.004 17.2 0.1 0.05 13.6 0.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF2089) zf-FCS PF06467.14 AIC14629.1 - 0.0043 17.0 3.5 0.0092 15.9 3.5 1.6 1 0 0 1 1 1 1 MYM-type Zinc finger with FCS sequence motif HTH_5 PF01022.20 AIC14629.1 - 0.032 14.1 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family PyrI_C PF02748.15 AIC14629.1 - 0.041 13.8 0.1 0.099 12.6 0.1 1.6 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain Lar_restr_allev PF14354.6 AIC14629.1 - 0.05 14.0 1.2 0.086 13.2 1.2 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar HTH_23 PF13384.6 AIC14629.1 - 0.084 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Homeodomain-like domain TxDE PF18711.1 AIC14629.1 - 0.09 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Toxoflavin-degrading enzyme HTH_IclR PF09339.10 AIC14629.1 - 0.095 12.5 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF4423 PF14394.6 AIC14629.1 - 0.11 12.2 0.1 5.6 6.6 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4423) RuvB_C PF05491.13 AIC14629.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain DUF2423 PF10338.9 AIC14629.1 - 0.13 12.5 0.7 0.29 11.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2423) ADK_lid PF05191.14 AIC14629.1 - 0.16 12.0 2.5 0.84 9.7 0.3 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid PMT_2 PF13231.6 AIC14630.1 - 2.7e-09 37.4 13.0 2.7e-09 37.4 13.0 2.7 2 0 0 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Glyco_transf_22 PF03901.17 AIC14630.1 - 1.9e-07 30.7 3.2 1.9e-07 30.7 3.2 2.3 2 1 0 2 2 2 1 Alg9-like mannosyltransferase family PMT PF02366.18 AIC14630.1 - 2.8e-07 30.4 13.1 2.8e-07 30.4 13.1 2.3 1 1 1 2 2 2 1 Dolichyl-phosphate-mannose-protein mannosyltransferase IncD PF17628.2 AIC14630.1 - 0.39 10.5 2.7 1.4 8.7 2.7 1.9 1 0 0 1 1 1 0 Inclusion membrane protein D CbiG_N PF11760.8 AIC14631.1 - 1.8e-32 111.1 0.5 4e-32 110.1 0.5 1.6 1 0 0 1 1 1 1 Cobalamin synthesis G N-terminal CbiG_C PF01890.16 AIC14631.1 - 3.2e-29 101.8 0.0 5.9e-29 101.0 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis G C-terminus CbiG_mid PF11761.8 AIC14631.1 - 1.2e-16 60.5 0.1 5.3e-16 58.5 0.1 2.0 2 0 0 2 2 2 1 Cobalamin biosynthesis central region CbiC PF02570.15 AIC14632.1 - 5e-75 251.5 0.3 9.5e-75 250.6 0.3 1.5 1 0 0 1 1 1 1 Precorrin-8X methylmutase CbiX PF01903.17 AIC14632.1 - 1.2e-34 118.8 0.0 1e-16 61.1 0.1 2.4 2 0 0 2 2 2 2 CbiX CbiK PF06180.11 AIC14632.1 - 7.6e-10 38.5 0.0 1.2e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Cobalt chelatase (CbiK) TPP_enzyme_M PF00205.22 AIC14632.1 - 0.031 14.0 0.1 12 5.6 0.0 3.2 3 0 0 3 3 3 0 Thiamine pyrophosphate enzyme, central domain GATase_3 PF07685.14 AIC14633.1 - 4.9e-39 134.0 0.0 6.8e-39 133.5 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain CbiA PF01656.23 AIC14633.1 - 9.7e-19 67.7 0.0 1.6e-18 67.0 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 AIC14633.1 - 1.8e-15 57.3 0.8 5.6e-10 39.4 0.0 2.5 2 0 0 2 2 2 2 AAA domain SNO PF01174.19 AIC14633.1 - 0.019 14.8 0.0 0.044 13.6 0.0 1.5 1 0 0 1 1 1 0 SNO glutamine amidotransferase family AAA_18 PF13238.6 AIC14633.1 - 0.089 13.3 0.0 0.33 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain CTP_synth_N PF06418.14 AIC14633.1 - 0.15 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 CTP synthase N-terminus bPH_3 PF14470.6 AIC14634.1 - 7.9e-12 45.4 0.0 1.2e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial PH domain DZR PF12773.7 AIC14634.1 - 9.2e-09 35.2 9.9 1.7e-08 34.3 9.9 1.5 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC14634.1 - 1.9e-07 30.2 7.8 0.013 14.9 1.3 3.3 3 0 0 3 3 3 3 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIC14634.1 - 2.6e-05 24.9 6.5 0.023 15.4 0.5 2.2 2 0 0 2 2 2 2 zinc-ribbon family SHOCT PF09851.9 AIC14634.1 - 0.00011 21.8 1.5 0.00022 20.9 1.5 1.5 1 0 0 1 1 1 1 Short C-terminal domain UPF0547 PF10571.9 AIC14634.1 - 0.0031 17.6 15.7 0.051 13.7 0.4 3.3 2 1 1 3 3 3 2 Uncharacterised protein family UPF0547 zinc-ribbons_6 PF07191.12 AIC14634.1 - 0.012 15.6 9.8 0.11 12.5 1.1 2.2 1 1 0 2 2 2 0 zinc-ribbons NOB1_Zn_bind PF08772.11 AIC14634.1 - 0.016 15.4 11.4 0.033 14.3 1.1 2.4 1 1 1 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 AIC14634.1 - 0.067 12.9 15.5 0.89 9.4 0.7 3.2 2 1 2 4 4 4 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 AIC14634.1 - 0.33 10.7 0.1 0.33 10.7 0.1 3.4 4 0 0 4 4 4 0 DNA directed RNA polymerase, 7 kDa subunit DUF2321 PF10083.9 AIC14634.1 - 0.54 9.9 3.8 0.83 9.3 3.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) zf_UBZ PF18439.1 AIC14634.1 - 0.97 9.1 6.4 6.2 6.5 0.1 2.9 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-NADH-PPase PF09297.11 AIC14634.1 - 2.1 8.1 7.7 0.37 10.5 0.8 2.8 2 1 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain OrfB_Zn_ribbon PF07282.11 AIC14634.1 - 7.6 6.5 6.6 1.4 8.9 0.6 2.3 1 1 1 2 2 2 0 Putative transposase DNA-binding domain RecR PF02132.15 AIC14634.1 - 7.7 6.2 7.8 1.6 8.4 0.6 2.8 2 1 0 2 2 2 0 RecR protein RNA_POL_M_15KD PF02150.16 AIC14634.1 - 9 6.3 12.8 2.7 7.9 3.0 3.2 2 1 1 3 3 3 0 RNA polymerases M/15 Kd subunit zf-RING_4 PF14570.6 AIC14634.1 - 9.7 6.1 11.0 5.1 7.0 2.1 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain CobA_CobO_BtuR PF02572.15 AIC14635.1 - 8e-62 208.5 1.4 8.9e-62 208.4 1.4 1.0 1 0 0 1 1 1 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP IstB_IS21 PF01695.17 AIC14635.1 - 0.0033 17.2 2.9 0.24 11.1 0.1 2.1 1 1 1 2 2 2 2 IstB-like ATP binding protein AAA_7 PF12775.7 AIC14635.1 - 0.19 11.2 0.2 1.3 8.5 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region CbiA PF01656.23 AIC14635.1 - 0.38 10.8 2.3 6.6 6.8 0.5 2.4 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain EIF_2_alpha PF07541.12 AIC14636.1 - 3e-18 66.0 2.7 3.6e-18 65.7 0.2 2.3 2 1 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 AIC14636.1 - 2.3e-13 50.3 0.5 5.5e-13 49.1 0.1 1.9 2 0 0 2 2 2 1 S1 RNA binding domain Skp1_POZ PF03931.15 AIC14636.1 - 0.024 14.8 0.1 0.062 13.5 0.1 1.7 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Nop10p PF04135.12 AIC14637.1 - 1.5e-21 76.1 3.5 1.7e-21 76.0 3.5 1.1 1 0 0 1 1 1 1 Nucleolar RNA-binding protein, Nop10p family PolC_DP2 PF03833.13 AIC14637.1 - 0.0015 16.5 0.3 0.0015 16.5 0.3 1.0 1 0 0 1 1 1 1 DNA polymerase II large subunit DP2 RecR PF02132.15 AIC14637.1 - 0.042 13.4 1.0 0.056 13.0 1.0 1.2 1 0 0 1 1 1 0 RecR protein zinc_ribbon_2 PF13240.6 AIC14637.1 - 0.1 12.3 3.9 1.7 8.5 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain DUF35_N PF12172.8 AIC14637.1 - 0.12 12.3 5.6 0.14 12.1 4.0 1.9 1 1 1 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-tcix PF14952.6 AIC14637.1 - 0.12 12.0 1.0 0.12 12.0 1.0 2.1 1 1 1 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding zf-ribbon_3 PF13248.6 AIC14637.1 - 0.12 11.8 4.9 0.51 9.8 4.9 1.9 1 1 0 1 1 1 0 zinc-ribbon domain zf-CCHC_6 PF15288.6 AIC14637.1 - 1.8 8.5 6.7 4 7.4 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-ACC PF17848.1 AIC14637.1 - 2 8.6 5.4 84 3.4 0.6 2.3 1 1 1 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Trp_halogenase PF04820.14 AIC14638.1 - 0.028 13.3 0.0 0.052 12.4 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase 4HBT PF03061.22 AIC14639.1 - 2.4e-17 63.0 0.5 3.3e-17 62.6 0.5 1.2 1 0 0 1 1 1 1 Thioesterase superfamily MaoC_dehydratas PF01575.19 AIC14639.1 - 0.00078 19.0 0.1 0.0012 18.4 0.1 1.3 1 0 0 1 1 1 1 MaoC like domain DUF4442 PF14539.6 AIC14639.1 - 0.09 12.9 0.3 0.22 11.7 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4442) ESM4 PF15952.5 AIC14640.1 - 0.021 15.3 0.1 0.021 15.3 0.1 1.0 1 0 0 1 1 1 0 Enhancer of split M4 family PEP_mutase PF13714.6 AIC14641.1 - 3.4e-54 183.8 0.0 4e-54 183.6 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 AIC14641.1 - 3e-12 45.8 0.0 6.2e-12 44.8 0.0 1.4 1 1 0 1 1 1 1 Isocitrate lyase family Glyoxalase PF00903.25 AIC14642.1 - 1.3e-10 41.5 0.0 2.3e-10 40.8 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 AIC14642.1 - 8e-06 25.8 0.0 1.1e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_6 PF18029.1 AIC14642.1 - 5.5e-05 23.9 0.0 6.9e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 AIC14642.1 - 0.17 12.2 0.0 0.38 11.0 0.0 1.6 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily TFIIS_C PF01096.18 AIC14643.1 - 0.0013 18.5 0.9 0.057 13.3 0.2 2.1 2 0 0 2 2 2 1 Transcription factor S-II (TFIIS) DUF3268 PF11672.8 AIC14643.1 - 0.0086 16.4 0.1 0.0087 16.4 0.1 1.1 1 0 0 1 1 1 1 zinc-finger-containing domain DUF2757 PF10955.8 AIC14643.1 - 0.0098 16.1 0.2 0.021 15.0 0.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2757) zinc-ribbons_6 PF07191.12 AIC14643.1 - 0.012 15.6 0.4 0.012 15.5 0.4 1.2 1 0 0 1 1 1 0 zinc-ribbons RNA_POL_M_15KD PF02150.16 AIC14643.1 - 0.015 15.2 3.0 0.088 12.7 3.0 2.0 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit SspK PF08176.12 AIC14643.1 - 0.015 15.5 0.0 0.02 15.1 0.0 1.2 1 0 0 1 1 1 0 Small acid-soluble spore protein K family Lar_restr_allev PF14354.6 AIC14643.1 - 0.073 13.5 1.3 0.11 12.9 1.3 1.3 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn_Tnp_IS1595 PF12760.7 AIC14643.1 - 0.13 12.2 2.1 0.29 11.2 2.1 1.6 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-H2C2_2 PF13465.6 AIC14643.1 - 0.47 11.0 2.9 2.4 8.7 0.3 2.1 2 0 0 2 2 2 0 Zinc-finger double domain HTH_24 PF13412.6 AIC14644.1 - 1.8e-07 30.6 0.1 2.9e-07 29.9 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC14644.1 - 1.6e-05 24.6 0.2 3e-05 23.8 0.2 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_5 PF01022.20 AIC14644.1 - 0.00029 20.6 0.1 0.00051 19.9 0.1 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC14644.1 - 0.0018 18.3 0.0 0.0038 17.3 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_IclR PF09339.10 AIC14644.1 - 0.0022 17.8 0.0 0.0041 16.9 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain AsnC_trans_reg PF01037.21 AIC14644.1 - 0.0044 17.0 0.0 0.0093 15.9 0.0 1.5 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain TrmB PF01978.19 AIC14644.1 - 0.0049 16.7 0.1 0.011 15.5 0.1 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIC14644.1 - 0.0057 16.6 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 AIC14644.1 - 0.04 13.9 0.1 0.073 13.0 0.1 1.4 1 0 0 1 1 1 0 HTH domain Sigma70_r4_2 PF08281.12 AIC14644.1 - 0.086 12.5 0.1 0.25 11.0 0.0 1.8 2 0 0 2 2 2 0 Sigma-70, region 4 Fe_dep_repress PF01325.19 AIC14644.1 - 0.13 12.5 0.2 0.35 11.1 0.1 1.7 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain AMMECR1 PF01871.17 AIC14645.1 - 4.1e-45 153.4 0.0 4.8e-45 153.2 0.0 1.0 1 0 0 1 1 1 1 AMMECR1 Glyco_trans_1_3 PF13528.6 AIC14646.1 - 2.1e-14 53.5 0.0 1.2e-06 28.0 0.0 2.1 2 0 0 2 2 2 2 Glycosyl transferase family 1 Glyco_tran_28_C PF04101.16 AIC14646.1 - 2.7e-12 47.0 0.0 4.6e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain UDPGT PF00201.18 AIC14646.1 - 1.2e-08 34.2 0.0 4.4e-08 32.4 0.0 1.8 2 0 0 2 2 2 1 UDP-glucoronosyl and UDP-glucosyl transferase Glycos_transf_1 PF00534.20 AIC14646.1 - 1.1e-05 25.1 0.0 2.3e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AIC14646.1 - 0.00051 20.5 0.0 0.0014 19.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 FixQ PF05545.11 AIC14648.1 - 0.0028 17.6 2.5 0.0038 17.2 2.5 1.2 1 0 0 1 1 1 1 Cbb3-type cytochrome oxidase component FixQ DUF347 PF03988.12 AIC14648.1 - 0.069 13.3 1.9 0.11 12.7 1.9 1.3 1 0 0 1 1 1 0 Repeat of Unknown Function (DUF347) Ribosomal_S13_N PF08069.12 AIC14651.1 - 4.6e-24 84.2 0.4 8.9e-24 83.3 0.4 1.5 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain Ribosomal_S15 PF00312.22 AIC14651.1 - 2.3e-10 40.6 0.4 3.6e-10 39.9 0.4 1.3 1 0 0 1 1 1 1 Ribosomal protein S15 Invasin_D3 PF09134.10 AIC14651.1 - 0.03 14.6 0.1 0.044 14.1 0.1 1.3 1 0 0 1 1 1 0 Invasin, domain 3 PAX PF00292.18 AIC14651.1 - 0.061 13.2 0.0 0.096 12.6 0.0 1.4 1 0 0 1 1 1 0 'Paired box' domain DHHA1 PF02272.19 AIC14652.1 - 9.6e-07 29.3 0.0 2.3e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 AIC14652.1 - 0.0026 18.0 0.0 0.005 17.0 0.0 1.5 1 0 0 1 1 1 1 DHH family NTP_transf_4 PF13562.6 AIC14652.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 Sugar nucleotidyl transferase Pcc1 PF09341.10 AIC14653.1 - 0.0058 16.7 0.5 0.02 15.0 0.5 1.9 1 1 0 1 1 1 1 Transcription factor Pcc1 tRNA-synt_2b PF00587.25 AIC14654.1 - 2.1e-38 132.1 0.1 4e-38 131.2 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) Seryl_tRNA_N PF02403.22 AIC14654.1 - 1.4e-23 83.2 11.3 2.5e-23 82.3 11.3 1.4 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain UPF0228 PF05727.11 AIC14654.1 - 0.033 14.0 0.0 0.13 12.1 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0228) LAM_C PF12544.8 AIC14654.1 - 0.098 12.8 0.9 0.33 11.1 0.0 2.2 2 0 0 2 2 2 0 Lysine-2,3-aminomutase FmiP_Thoc5 PF09766.9 AIC14654.1 - 0.13 11.6 5.5 0.19 11.0 5.5 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 FbpA PF05833.11 AIC14654.1 - 0.36 9.5 6.8 0.63 8.7 4.9 2.0 2 0 0 2 2 2 0 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_S3Ae PF01015.18 AIC14655.1 - 1.8e-57 194.2 0.7 2.1e-57 194.0 0.7 1.0 1 0 0 1 1 1 1 Ribosomal S3Ae family RNA_binding PF01877.17 AIC14656.1 - 5.9e-27 94.3 0.0 7e-27 94.1 0.0 1.1 1 0 0 1 1 1 1 RNA binding RNase_P_p30 PF01876.16 AIC14657.1 - 0.00022 20.8 0.0 0.00026 20.5 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit p30 RNase_P_Rpp14 PF01900.19 AIC14658.1 - 0.0057 16.9 0.1 0.0069 16.6 0.1 1.3 1 0 0 1 1 1 1 Rpp14/Pop5 family DUF4807 PF16065.5 AIC14658.1 - 0.053 13.2 0.1 0.076 12.7 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4807) DUF5643 PF18705.1 AIC14660.1 - 8.6e-06 25.7 0.0 1.6e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5643) CDC48_N PF02359.18 AIC14660.1 - 0.0033 17.6 0.0 0.011 15.9 0.0 1.8 1 1 1 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain CDC48_2 PF02933.17 AIC14660.1 - 0.029 14.1 0.0 0.095 12.5 0.0 1.9 2 0 0 2 2 2 0 Cell division protein 48 (CDC48), domain 2 MRP-S34 PF16053.5 AIC14660.1 - 0.11 12.2 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S34 Radical_SAM PF04055.21 AIC14661.1 - 2.4e-15 57.3 0.1 3.4e-14 53.5 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily zf-C2H2_aberr PF17017.5 AIC14661.1 - 0.22 11.7 1.9 0.86 9.7 0.3 2.2 1 1 1 2 2 2 0 Aberrant zinc-finger Polysacc_deac_1 PF01522.21 AIC14662.1 - 9e-12 45.0 0.0 1.8e-11 44.0 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIC14662.1 - 6.9e-06 25.9 0.0 1.4e-05 24.8 0.0 1.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 AIC14662.1 - 0.028 13.6 0.0 0.053 12.7 0.0 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 57 UPF0180 PF03698.13 AIC14662.1 - 0.053 13.7 0.0 8.2 6.7 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) PhoU_div PF01865.16 AIC14663.1 - 7.2e-16 58.2 4.0 8.6e-16 57.9 4.0 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PhoU PF01895.19 AIC14663.1 - 0.0012 19.2 5.9 0.45 11.0 1.9 2.5 2 1 0 2 2 2 2 PhoU domain Lebercilin PF15619.6 AIC14663.1 - 0.047 13.4 5.0 0.041 13.6 1.8 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TraD PF06412.11 AIC14663.1 - 0.12 12.3 0.5 0.74 9.7 0.1 2.3 2 0 0 2 2 2 0 Conjugal transfer protein TraD ABC_tran_CTD PF16326.5 AIC14663.1 - 0.58 10.4 3.3 8.3 6.7 0.1 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain tRNA_int_endo PF01974.17 AIC14664.1 - 8.9e-27 93.0 0.0 1.4e-26 92.3 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain tRNA_int_endo_N PF02778.14 AIC14664.1 - 3.7e-18 64.9 0.0 5.7e-18 64.4 0.0 1.3 1 0 0 1 1 1 1 tRNA intron endonuclease, N-terminal domain RB_B PF01857.20 AIC14665.1 - 0.065 13.3 0.3 0.14 12.1 0.1 1.6 2 0 0 2 2 2 0 Retinoblastoma-associated protein B domain Arm-DNA-bind_4 PF14657.6 AIC14666.1 - 0.056 13.2 1.2 0.056 13.2 1.2 2.0 2 1 0 2 2 2 0 Arm DNA-binding domain HIT PF01230.23 AIC14667.1 - 2.1e-24 86.1 0.6 3.5e-24 85.4 0.1 1.5 2 0 0 2 2 2 1 HIT domain DcpS_C PF11969.8 AIC14667.1 - 1.7e-13 51.0 0.0 2.8e-13 50.4 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding UAF_Rrn10 PF05234.11 AIC14667.1 - 0.17 12.1 0.0 0.25 11.6 0.0 1.3 1 0 0 1 1 1 0 UAF complex subunit Rrn10 CwfJ_C_1 PF04677.15 AIC14667.1 - 0.57 10.1 2.4 1.3 8.9 2.4 1.8 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 ApoA-II PF04711.13 AIC14669.1 - 0.018 15.2 0.0 0.032 14.4 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein A-II (ApoA-II) SAPI PF16560.5 AIC14669.1 - 0.037 13.6 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Putative mobile pathogenicity island DUF937 PF06078.11 AIC14669.1 - 0.18 12.4 13.0 3.4 8.3 5.2 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF937) Elf1 PF05129.13 AIC14670.1 - 0.0085 16.1 0.1 0.01 15.8 0.1 1.2 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like zinc_ribbon_4 PF13717.6 AIC14670.1 - 0.0087 16.0 0.1 4.7 7.2 0.0 2.2 2 0 0 2 2 2 2 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIC14670.1 - 0.026 14.5 0.2 0.03 14.2 0.2 1.1 1 0 0 1 1 1 0 Putative transposase DNA-binding domain zinc_ribbon_5 PF13719.6 AIC14670.1 - 0.037 13.8 0.6 2.5 7.9 0.0 2.1 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 AIC14670.1 - 0.056 13.5 0.1 0.06 13.4 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_10 PF18414.1 AIC14670.1 - 0.088 12.4 0.3 0.17 11.4 0.3 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger Zn-ribbon_8 PF09723.10 AIC14670.1 - 0.14 12.3 2.8 0.43 10.7 2.9 1.7 1 1 0 1 1 1 0 Zinc ribbon domain zf-C2H2 PF00096.26 AIC14670.1 - 0.74 10.4 3.2 24 5.6 1.1 2.2 2 0 0 2 2 2 0 Zinc finger, C2H2 type PheRS_DBD1 PF18552.1 AIC14671.1 - 0.17 11.6 0.0 0.26 11.1 0.0 1.2 1 0 0 1 1 1 0 PheRS DNA binding domain 1 ILVD_EDD PF00920.21 AIC14672.1 - 2.2e-215 716.1 9.6 2.5e-215 716.0 9.6 1.0 1 0 0 1 1 1 1 Dehydratase family Chorismate_bind PF00425.18 AIC14673.1 - 2.7e-97 325.4 0.0 3.5e-96 321.7 0.0 2.0 2 0 0 2 2 2 1 chorismate binding enzyme Anth_synt_I_N PF04715.13 AIC14673.1 - 1.5e-26 93.3 0.0 7.4e-23 81.3 0.0 2.6 2 0 0 2 2 2 2 Anthranilate synthase component I, N terminal region PALP PF00291.25 AIC14674.1 - 2.6e-51 174.8 0.0 3.7e-51 174.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PK_C PF02887.16 AIC14674.1 - 0.079 13.2 2.5 1.8 8.8 1.2 2.5 2 1 0 2 2 2 0 Pyruvate kinase, alpha/beta domain Acetyltransf_1 PF00583.25 AIC14676.1 - 1.8e-16 60.4 0.2 2.3e-16 60.1 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AIC14676.1 - 1.3e-11 44.6 0.3 2.1e-11 43.9 0.2 1.3 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AIC14676.1 - 1.2e-10 41.7 0.9 2.1e-10 40.9 0.9 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AIC14676.1 - 5.5e-08 33.1 0.0 6.9e-08 32.8 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 AIC14676.1 - 5.3e-06 27.2 0.0 6.4e-06 26.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIC14676.1 - 0.0016 18.6 0.1 0.0065 16.5 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 AIC14676.1 - 0.0035 17.0 0.1 0.0091 15.7 0.0 1.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 AIC14676.1 - 0.0056 16.2 0.0 0.0088 15.5 0.0 1.3 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_CG PF14542.6 AIC14676.1 - 0.0073 16.4 0.0 0.012 15.7 0.0 1.5 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 AIC14676.1 - 0.02 14.8 0.1 0.037 14.0 0.1 1.4 1 0 0 1 1 1 0 FR47-like protein Microvir_H PF04687.12 AIC14677.1 - 0.017 14.5 0.6 0.028 13.8 0.6 1.3 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Ins_allergen_rp PF06757.13 AIC14677.1 - 0.024 14.6 0.1 0.035 14.1 0.1 1.2 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification Snf7 PF03357.21 AIC14677.1 - 0.088 12.4 6.0 0.16 11.6 6.0 1.5 1 1 0 1 1 1 0 Snf7 DASH_Duo1 PF08651.10 AIC14677.1 - 0.14 12.0 1.8 1.3 8.8 0.2 2.4 2 0 0 2 2 2 0 DASH complex subunit Duo1 Aminotran_1_2 PF00155.21 AIC14679.1 - 7.5e-56 189.8 0.3 8.7e-56 189.6 0.3 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AIC14679.1 - 4.8e-06 25.3 0.1 7.1e-06 24.8 0.1 1.1 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 AIC14679.1 - 0.0024 17.2 0.5 0.026 13.8 0.5 2.3 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 AIC14679.1 - 0.016 14.2 0.2 0.025 13.6 0.2 1.2 1 0 0 1 1 1 0 Aminotransferase class-V BATS PF06968.13 AIC14680.1 - 1.2e-15 57.4 0.1 9.9e-15 54.5 0.0 2.3 2 0 0 2 2 2 1 Biotin and Thiamin Synthesis associated domain Radical_SAM PF04055.21 AIC14680.1 - 2.2e-15 57.4 0.6 4.3e-15 56.5 0.6 1.5 1 0 0 1 1 1 1 Radical SAM superfamily DeoC PF01791.9 AIC14680.1 - 0.064 12.9 0.0 6.6 6.3 0.0 2.3 2 0 0 2 2 2 0 DeoC/LacD family aldolase Cupin_2 PF07883.11 AIC14681.1 - 2.2e-12 46.5 0.1 4.2e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 AIC14681.1 - 2.7e-07 30.6 0.0 4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 AraC-like ligand binding domain EutQ PF06249.12 AIC14681.1 - 6.7e-06 25.9 0.0 1.1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Ethanolamine utilisation protein EutQ Cupin_3 PF05899.12 AIC14681.1 - 2e-05 24.2 0.0 3.9e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF861) MannoseP_isomer PF01050.18 AIC14681.1 - 0.00084 19.3 0.0 0.0012 18.8 0.0 1.2 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_7 PF12973.7 AIC14681.1 - 0.0011 18.8 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 ChrR Cupin-like domain Cupin_1 PF00190.22 AIC14681.1 - 0.0024 17.5 0.1 0.0054 16.4 0.1 1.6 1 1 0 1 1 1 1 Cupin DMSP_lyase PF16867.5 AIC14681.1 - 0.0036 17.0 0.1 0.0054 16.4 0.1 1.2 1 0 0 1 1 1 1 Dimethlysulfonioproprionate lyase Cupin_6 PF12852.7 AIC14681.1 - 0.018 14.7 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Cupin ARD PF03079.14 AIC14681.1 - 0.023 14.9 0.0 0.034 14.3 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Resolvase PF00239.21 AIC14682.1 - 6.9e-34 117.1 0.1 9.8e-34 116.6 0.1 1.2 1 0 0 1 1 1 1 Resolvase, N terminal domain HTH_7 PF02796.15 AIC14682.1 - 8.3e-07 29.0 0.2 1.8e-06 27.9 0.2 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase HTH_23 PF13384.6 AIC14682.1 - 7.9e-06 25.5 2.4 9e-06 25.3 0.1 2.1 2 0 0 2 2 2 1 Homeodomain-like domain HTH_38 PF13936.6 AIC14682.1 - 3.5e-05 23.5 0.5 3.5e-05 23.5 0.5 2.1 1 1 1 2 2 2 1 Helix-turn-helix domain CENP-B_N PF04218.13 AIC14682.1 - 0.00048 19.7 0.1 0.0037 16.9 0.1 2.4 2 1 1 3 3 3 1 CENP-B N-terminal DNA-binding domain HTH_30 PF13556.6 AIC14682.1 - 0.0016 18.2 0.1 0.0031 17.3 0.1 1.5 1 0 0 1 1 1 1 PucR C-terminal helix-turn-helix domain HTH_Tnp_1_2 PF13022.6 AIC14682.1 - 0.0018 18.4 0.1 0.026 14.7 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix of insertion element transposase HTH_28 PF13518.6 AIC14682.1 - 0.0025 17.9 0.7 0.0077 16.3 0.1 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_22 PF13309.6 AIC14682.1 - 0.0042 17.1 0.1 0.016 15.3 0.0 2.0 2 0 0 2 2 2 1 HTH domain HTH_10 PF04967.12 AIC14682.1 - 0.0049 16.6 0.2 0.011 15.5 0.2 1.6 1 0 0 1 1 1 1 HTH DNA binding domain HTH_29 PF13551.6 AIC14682.1 - 0.0067 16.4 1.1 0.034 14.1 0.1 2.3 2 0 0 2 2 2 1 Winged helix-turn helix HTH_11 PF08279.12 AIC14682.1 - 0.0081 16.1 0.6 0.022 14.7 0.6 1.7 1 0 0 1 1 1 1 HTH domain TetR_N PF00440.23 AIC14682.1 - 0.012 15.4 0.0 0.031 14.1 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, tetR family HTH_Tnp_ISL3 PF13542.6 AIC14682.1 - 0.02 14.3 0.0 0.054 12.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_8 PF02954.19 AIC14682.1 - 0.044 13.6 1.4 0.044 13.6 1.4 2.2 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family HTH_Tnp_1 PF01527.20 AIC14682.1 - 0.066 13.5 0.3 0.15 12.4 0.0 1.8 2 0 0 2 2 1 0 Transposase DUF1492 PF07374.11 AIC14682.1 - 0.084 13.0 0.1 0.32 11.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) Mga PF05043.13 AIC14682.1 - 0.099 13.2 0.2 0.32 11.6 0.1 1.8 2 0 0 2 2 2 0 Mga helix-turn-helix domain DUF4886 PF16227.5 AIC14682.1 - 0.15 11.2 0.1 0.21 10.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) Aminotran_3 PF00202.21 AIC14683.1 - 3.2e-94 315.9 0.0 4.1e-94 315.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III FAD_binding_2 PF00890.24 AIC14683.1 - 0.0036 16.4 0.1 0.0099 15.0 0.0 1.8 3 0 0 3 3 3 1 FAD binding domain Aminotran_1_2 PF00155.21 AIC14683.1 - 0.017 14.3 0.1 0.051 12.8 0.0 1.7 2 0 0 2 2 2 0 Aminotransferase class I and II Repressor_Mnt PF11423.8 AIC14683.1 - 1.2 9.0 5.1 2 8.2 2.3 2.5 2 0 0 2 2 2 0 Regulatory protein Mnt AAA_26 PF13500.6 AIC14684.1 - 1.2e-39 136.2 0.0 1.5e-39 135.9 0.0 1.0 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 AIC14684.1 - 1.7e-11 44.3 0.0 2.9e-11 43.5 0.0 1.4 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 AIC14684.1 - 6.6e-06 25.8 0.2 0.077 12.4 0.1 2.3 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase DUF1611 PF07755.11 AIC14684.1 - 0.0073 15.6 0.8 0.068 12.4 0.2 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF1611_C) P-loop domain ArsA_ATPase PF02374.15 AIC14684.1 - 0.011 14.9 0.5 0.028 13.6 0.2 1.7 2 1 0 2 2 2 0 Anion-transporting ATPase CTP_synth_N PF06418.14 AIC14684.1 - 0.029 13.7 0.2 0.3 10.3 0.1 2.4 3 0 0 3 3 3 0 CTP synthase N-terminus NTPase_1 PF03266.15 AIC14684.1 - 0.045 13.7 0.4 1.6 8.7 0.1 2.4 2 1 0 2 2 2 0 NTPase ResIII PF04851.15 AIC14684.1 - 0.097 12.7 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Maelstrom PF13017.6 AIC14685.1 - 0.11 12.1 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 piRNA pathway germ-plasm component DUF2157 PF09925.9 AIC14686.1 - 0.28 11.0 4.8 1.2 8.9 3.4 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2157) SLAC1 PF03595.17 AIC14686.1 - 0.57 9.4 5.7 0.71 9.1 5.7 1.2 1 0 0 1 1 1 0 Voltage-dependent anion channel DUF3995 PF13160.6 AIC14686.1 - 7.2 7.0 10.5 1.1 9.6 6.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3995) NTP_transferase PF00483.23 AIC14687.1 - 6.8e-35 120.8 0.0 1.2e-34 120.0 0.0 1.4 1 1 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 AIC14687.1 - 6.8e-08 33.0 0.0 9.3e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 AIC14687.1 - 0.01 15.6 0.0 0.014 15.1 0.0 1.2 1 0 0 1 1 1 0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase Bac_luciferase PF00296.20 AIC14688.1 - 1.3e-66 225.1 0.0 1.5e-66 224.9 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Thiolase_N PF00108.23 AIC14689.1 - 5.2e-14 52.2 7.2 3.1e-12 46.4 5.1 3.3 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AIC14689.1 - 1.9e-09 37.2 1.4 3.2e-09 36.5 0.5 1.9 2 0 0 2 2 2 1 Thiolase, C-terminal domain ACP_syn_III PF08545.10 AIC14689.1 - 1e-05 25.3 0.1 0.00033 20.4 0.2 2.6 2 0 0 2 2 2 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III ketoacyl-synt PF00109.26 AIC14689.1 - 7.3e-05 22.5 0.8 0.00011 21.9 0.1 1.6 2 0 0 2 2 2 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 AIC14689.1 - 0.019 15.0 6.2 0.048 13.7 1.7 3.2 1 1 1 2 2 2 0 Beta-ketoacyl synthase, C-terminal domain OB_aCoA_assoc PF01796.17 AIC14690.1 - 0.0088 16.0 0.0 0.019 15.0 0.0 1.5 1 1 0 1 1 1 1 DUF35 OB-fold domain, acyl-CoA-associated DUF35_N PF12172.8 AIC14690.1 - 0.013 15.4 4.7 0.03 14.2 4.7 1.7 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Ribosomal_L6 PF00347.23 AIC14693.1 - 4.5e-17 62.5 10.5 7.5e-09 36.2 2.9 2.1 2 0 0 2 2 2 2 Ribosomal protein L6 DUF2067 PF09840.9 AIC14693.1 - 0.042 13.4 2.3 0.12 11.9 0.4 2.1 1 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2067) Glyco_hydro_65C PF03633.15 AIC14693.1 - 0.28 11.1 1.1 13 5.8 0.2 3.1 2 1 1 3 3 3 0 Glycosyl hydrolase family 65, C-terminal domain Ribosomal_S8 PF00410.19 AIC14694.1 - 1.8e-24 86.1 0.0 2.1e-24 85.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein S8 Ribosomal_S14 PF00253.21 AIC14695.1 - 3.5e-10 39.5 4.1 5e-10 39.0 4.0 1.3 1 1 0 1 1 1 1 Ribosomal protein S14p/S29e zf-tcix PF14952.6 AIC14695.1 - 0.002 17.7 0.9 0.002 17.7 0.9 1.7 2 0 0 2 2 2 1 Putative treble-clef, zinc-finger, Zn-binding Ribosomal_L5_C PF00673.21 AIC14696.1 - 1.1e-22 80.0 0.0 1.9e-22 79.2 0.0 1.4 1 0 0 1 1 1 1 ribosomal L5P family C-terminus Ribosomal_L5 PF00281.19 AIC14696.1 - 6.2e-15 55.3 0.2 1.4e-14 54.1 0.2 1.7 1 0 0 1 1 1 1 Ribosomal protein L5 Prefoldin PF02996.17 AIC14696.1 - 0.17 11.8 1.3 7.2 6.5 0.1 2.7 2 1 2 4 4 4 0 Prefoldin subunit Ribosomal_S4e PF00900.20 AIC14697.1 - 1e-15 57.4 0.0 1.9e-15 56.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal family S4e RS4NT PF08071.12 AIC14697.1 - 5e-10 39.3 0.4 7.9e-10 38.7 0.4 1.3 1 0 0 1 1 1 1 RS4NT (NUC023) domain S4 PF01479.25 AIC14697.1 - 1.1e-05 25.0 0.2 3e-05 23.6 0.2 1.7 1 0 0 1 1 1 1 S4 domain Ribosomal_L26 PF16906.5 AIC14698.1 - 6.8e-19 68.1 0.1 1.4e-18 67.1 0.1 1.5 1 0 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 AIC14698.1 - 1.8e-05 24.5 3.1 1.8e-05 24.5 3.1 1.9 2 0 0 2 2 2 1 KOW motif CMAS PF02353.20 AIC14698.1 - 0.006 15.9 0.1 0.0084 15.4 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Coilin_N PF15862.5 AIC14698.1 - 0.0094 15.8 0.9 0.013 15.3 0.9 1.3 1 1 0 1 1 1 1 Coilin N-terminus RR_TM4-6 PF06459.12 AIC14698.1 - 0.063 13.1 6.0 0.07 13.0 6.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ribosomal_L14 PF00238.19 AIC14699.1 - 6.9e-33 113.3 0.1 8.7e-33 113.0 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e Ribosomal_S17 PF00366.20 AIC14700.1 - 7.7e-23 80.4 1.8 9.5e-23 80.1 1.8 1.1 1 0 0 1 1 1 1 Ribosomal protein S17 DUF4411 PF14367.6 AIC14700.1 - 0.032 14.2 0.0 0.037 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Ribosomal_S17_N PF16205.5 AIC14700.1 - 0.04 14.3 0.0 0.086 13.2 0.0 1.6 1 0 0 1 1 1 0 Ribosomal_S17 N-terminal UPF0086 PF01868.16 AIC14701.1 - 5.6e-17 61.4 0.0 6.8e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function UPF0086 Ribosomal_L29 PF00831.23 AIC14702.1 - 1.4e-15 57.0 3.0 1.8e-15 56.6 3.0 1.2 1 0 0 1 1 1 1 Ribosomal L29 protein Ribosomal_S3_C PF00189.20 AIC14703.1 - 8.1e-20 71.1 1.8 1.7e-19 70.1 1.1 1.9 2 0 0 2 2 2 1 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 AIC14703.1 - 3.7e-13 49.1 0.0 6.1e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 KH domain Ribosomal_L22 PF00237.19 AIC14704.1 - 9.9e-26 90.0 1.0 1.4e-25 89.5 1.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ribosomal_S19 PF00203.21 AIC14705.1 - 2.1e-28 98.0 0.1 2.7e-28 97.7 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S19 Ribosomal_L23 PF00276.20 AIC14706.1 - 2.7e-11 43.7 0.9 4e-11 43.1 0.9 1.2 1 0 0 1 1 1 1 Ribosomal protein L23 Ge1_WD40 PF16529.5 AIC14706.1 - 0.057 12.4 0.0 0.065 12.2 0.0 1.0 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Ribosomal_L4 PF00573.22 AIC14707.1 - 5.2e-36 124.1 0.6 6.1e-36 123.9 0.6 1.0 1 0 0 1 1 1 1 Ribosomal protein L4/L1 family Ribosomal_L3 PF00297.22 AIC14708.1 - 2.1e-71 240.9 3.3 1.2e-70 238.4 3.3 1.8 1 1 0 1 1 1 1 Ribosomal protein L3 Methyltrn_RNA_3 PF02598.17 AIC14709.1 - 1.4e-54 185.5 0.0 1.6e-54 185.4 0.0 1.0 1 0 0 1 1 1 1 Putative RNA methyltransferase SPOUT_MTase_2 PF14419.6 AIC14709.1 - 1.6e-05 24.4 0.0 2.8e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 AF2226-like SPOUT RNA Methylase fused to THUMP Redoxin PF08534.10 AIC14710.1 - 8.5e-08 32.0 0.0 1.9e-05 24.4 0.0 2.2 2 0 0 2 2 2 2 Redoxin AhpC-TSA PF00578.21 AIC14710.1 - 3.2e-07 30.3 0.0 1.1e-05 25.3 0.0 2.2 1 1 0 1 1 1 1 AhpC/TSA family GSHPx PF00255.19 AIC14710.1 - 0.0086 15.6 0.1 0.017 14.7 0.1 1.5 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin_2 PF13098.6 AIC14710.1 - 0.04 14.4 0.1 0.4 11.2 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain Proteasome PF00227.26 AIC14711.1 - 2e-57 193.8 0.7 2.6e-57 193.4 0.7 1.2 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 AIC14711.1 - 2e-14 52.9 1.0 1.4e-13 50.2 0.1 2.6 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature P_proprotein PF01483.20 AIC14711.1 - 0.19 11.8 0.0 0.75 9.9 0.0 2.0 2 1 1 3 3 3 0 Proprotein convertase P-domain DUF371 PF04027.13 AIC14713.1 - 1.5e-45 154.4 0.5 1.7e-45 154.3 0.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF371) HTH_20 PF12840.7 AIC14714.1 - 1.7e-11 44.0 0.4 3.6e-11 42.9 0.4 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_5 PF01022.20 AIC14714.1 - 1.5e-09 37.6 0.1 8.5e-09 35.1 0.1 2.1 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_12 PF08461.10 AIC14714.1 - 1e-05 25.4 0.1 2.4e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain PadR PF03551.14 AIC14714.1 - 4.1e-05 23.4 0.1 0.0001 22.2 0.0 1.7 2 0 0 2 2 2 1 Transcriptional regulator PadR-like family TBPIP PF07106.13 AIC14714.1 - 0.0049 16.8 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain DUF4423 PF14394.6 AIC14714.1 - 0.0073 16.0 0.0 0.011 15.4 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) TrmB PF01978.19 AIC14714.1 - 0.0092 15.8 0.1 0.024 14.5 0.1 1.6 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 AIC14714.1 - 0.013 15.3 0.1 0.057 13.3 0.1 2.0 1 1 0 1 1 1 0 MarR family RE_BstXI PF09552.10 AIC14714.1 - 0.02 14.1 0.3 0.074 12.2 0.1 1.8 1 1 1 2 2 2 0 BstXI restriction endonuclease TFIIE_alpha PF02002.17 AIC14714.1 - 0.024 14.5 0.0 0.072 13.0 0.0 1.7 2 0 0 2 2 2 0 TFIIE alpha subunit HTH_11 PF08279.12 AIC14714.1 - 0.027 14.4 0.0 0.34 10.9 0.0 2.2 1 1 0 1 1 1 0 HTH domain FUR PF01475.19 AIC14714.1 - 0.032 14.4 0.0 0.055 13.6 0.0 1.3 1 0 0 1 1 1 0 Ferric uptake regulator family Ribosomal_L12 PF00542.19 AIC14714.1 - 0.036 14.4 0.8 2.2 8.7 0.0 2.6 2 1 1 3 3 2 0 Ribosomal protein L7/L12 C-terminal domain HTH_24 PF13412.6 AIC14714.1 - 0.038 13.6 0.0 0.31 10.7 0.0 2.4 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding DprA_WH PF17782.1 AIC14714.1 - 0.04 14.0 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 DprA winged helix domain Type2_restr_D3 PF16902.5 AIC14714.1 - 0.045 13.7 0.0 0.18 11.8 0.0 1.9 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain DUF2716 PF10898.8 AIC14714.1 - 0.087 13.2 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2716) DBR1 PF05011.13 AIC14714.1 - 0.11 12.9 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Lariat debranching enzyme, C-terminal domain LexA_DNA_bind PF01726.16 AIC14714.1 - 0.12 12.2 0.1 0.25 11.1 0.1 1.6 1 0 0 1 1 1 0 LexA DNA binding domain Ntox27 PF15531.6 AIC14714.1 - 0.17 11.8 0.1 0.34 10.8 0.1 1.5 1 1 0 2 2 2 0 Bacterial toxin 27 SAICAR_synt PF01259.18 AIC14715.1 - 1.5e-70 237.7 0.0 1.8e-70 237.5 0.0 1.0 1 0 0 1 1 1 1 SAICAR synthetase ATP-grasp PF02222.22 AIC14716.1 - 1.2e-59 200.7 0.1 1.8e-59 200.1 0.1 1.2 1 0 0 1 1 1 1 ATP-grasp domain PurK_C PF17769.1 AIC14716.1 - 1.6e-16 59.7 0.0 3e-16 58.8 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosylaminoimidazole carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 AIC14716.1 - 1.5e-06 27.9 0.1 5.8e-06 26.0 0.1 1.8 1 1 0 1 1 1 1 D-ala D-ala ligase C-terminus CPSase_L_D2 PF02786.17 AIC14716.1 - 1.2e-05 24.9 0.0 2.1e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_3 PF02655.14 AIC14716.1 - 6.2e-05 23.1 0.1 0.00012 22.2 0.1 1.5 1 0 0 1 1 1 1 ATP-grasp domain LAL_C2 PF18603.1 AIC14716.1 - 7.9e-05 22.7 0.3 0.00068 19.7 0.3 2.5 1 1 0 1 1 1 1 L-amino acid ligase C-terminal domain 2 RimK PF08443.11 AIC14716.1 - 0.00011 21.9 0.0 0.0002 21.0 0.0 1.4 1 1 0 1 1 1 1 RimK-like ATP-grasp domain ATPgrasp_ST PF14397.6 AIC14716.1 - 0.0023 17.2 0.1 0.53 9.5 0.0 2.4 1 1 1 2 2 2 2 Sugar-transfer associated ATP-grasp ATP-grasp_5 PF13549.6 AIC14716.1 - 0.021 14.3 0.0 0.041 13.3 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain GARS_A PF01071.19 AIC14716.1 - 0.028 14.2 0.0 0.047 13.5 0.0 1.4 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_2 PF08442.10 AIC14716.1 - 0.09 12.3 0.0 0.17 11.4 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp domain ATPgrasp_YheCD PF14398.6 AIC14716.1 - 0.15 11.2 0.0 0.98 8.6 0.0 2.0 1 1 0 2 2 2 0 YheC/D like ATP-grasp AIRC PF00731.20 AIC14717.1 - 1.5e-67 225.8 1.8 1.7e-67 225.6 1.8 1.0 1 0 0 1 1 1 1 AIR carboxylase CoA_binding_2 PF13380.6 AIC14717.1 - 0.064 13.8 0.1 8.8 6.9 0.0 2.1 1 1 0 2 2 2 0 CoA binding domain Nif11 PF07862.11 AIC14719.1 - 0.094 13.0 0.2 0.2 12.0 0.1 1.6 2 0 0 2 2 2 0 Nif11 domain Glyco_hydro_59 PF02057.15 AIC14719.1 - 0.098 11.9 0.1 0.15 11.2 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 59 adh_short PF00106.25 AIC14720.1 - 3.8e-46 157.0 0.4 4.9e-40 137.1 0.1 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 AIC14720.1 - 8.3e-43 146.6 2.0 1.2e-32 113.4 0.0 3.1 2 1 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIC14720.1 - 1.3e-16 61.0 0.5 4.2e-11 43.1 0.2 3.0 3 1 0 3 3 3 2 KR domain Epimerase PF01370.21 AIC14720.1 - 2.9e-06 26.9 0.3 0.003 17.0 0.0 2.5 2 1 0 2 2 2 2 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 AIC14720.1 - 0.00099 19.0 0.3 0.00099 19.0 0.3 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIC14720.1 - 0.0017 17.8 1.1 0.003 17.0 0.3 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 AIC14720.1 - 0.0036 16.6 0.3 0.045 13.1 0.1 2.6 2 1 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain F420_oxidored PF03807.17 AIC14720.1 - 0.013 16.0 0.4 0.068 13.8 0.2 2.3 2 0 0 2 2 1 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 AIC14720.1 - 0.027 14.9 1.4 0.13 12.7 0.1 2.7 3 1 0 3 3 3 0 Putative NAD(P)-binding ApbA PF02558.16 AIC14720.1 - 0.037 13.7 0.1 3.9 7.1 0.0 2.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA NIBRIN_BRCT_II PF16508.5 AIC14720.1 - 0.18 12.1 1.6 19 5.6 0.1 2.8 2 0 0 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein GRDA PF04723.14 AIC14720.1 - 0.27 11.0 5.7 14 5.4 0.0 3.9 4 0 0 4 4 4 0 Glycine reductase complex selenoprotein A V-ATPase_G PF03179.15 AIC14720.1 - 0.3 11.6 2.2 3.2 8.3 1.2 2.3 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit NAD_binding_10 PF13460.6 AIC14720.1 - 6.5 6.6 8.7 6.7 6.5 0.2 3.4 3 1 0 3 3 3 0 NAD(P)H-binding TauE PF01925.19 AIC14721.1 - 7.7e-54 182.8 36.0 9.3e-54 182.6 36.0 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE Glucos_trans_II PF14264.6 AIC14721.1 - 0.08 12.3 9.2 0.11 11.8 9.2 1.3 1 0 0 1 1 1 0 Glucosyl transferase GtrII DUF5423 PF17461.2 AIC14721.1 - 8.7 5.1 11.2 0.62 8.9 1.3 2.3 1 1 0 2 2 2 0 Family of unknown function (DUF5423) HTH_AsnC-type PF13404.6 AIC14722.1 - 4e-11 42.6 1.4 6.7e-11 41.8 0.1 2.0 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 AIC14722.1 - 3.2e-10 39.8 0.5 1e-09 38.2 0.0 2.0 3 0 0 3 3 3 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 AIC14722.1 - 4.7e-09 35.7 0.6 9e-09 34.8 0.6 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HrcA_DNA-bdg PF03444.15 AIC14722.1 - 0.00018 21.1 0.2 0.00059 19.4 0.1 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix transcription repressor, HrcA DNA-binding NapD PF03927.13 AIC14722.1 - 0.00073 19.5 0.1 0.0013 18.7 0.1 1.4 1 0 0 1 1 1 1 NapD protein HTH_11 PF08279.12 AIC14722.1 - 0.0015 18.5 0.1 0.0029 17.5 0.1 1.5 1 0 0 1 1 1 1 HTH domain HTH_Crp_2 PF13545.6 AIC14722.1 - 0.02 14.8 0.1 0.093 12.7 0.1 2.1 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_Mga PF08280.11 AIC14722.1 - 0.06 13.4 0.0 0.099 12.7 0.0 1.3 1 0 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain HTH_DeoR PF08220.12 AIC14722.1 - 0.062 13.1 0.3 0.11 12.2 0.3 1.4 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain DUF2250 PF10007.9 AIC14722.1 - 0.066 13.3 0.0 2.5 8.3 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) MarR PF01047.22 AIC14722.1 - 0.067 13.1 0.0 0.23 11.4 0.1 1.8 2 0 0 2 2 2 0 MarR family Homoserine_dh PF00742.19 AIC14723.1 - 8.8e-54 182.0 0.1 1.6e-53 181.2 0.1 1.4 1 0 0 1 1 1 1 Homoserine dehydrogenase NAD_binding_3 PF03447.16 AIC14723.1 - 6.9e-08 33.2 0.0 1.7e-07 31.9 0.0 1.7 1 0 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 AIC14723.1 - 2.8e-06 27.3 0.1 7.6e-06 25.8 0.1 1.7 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GFO_IDH_MocA PF01408.22 AIC14723.1 - 0.097 13.5 0.0 0.19 12.5 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold zinc_ribbon_6 PF14599.6 AIC14724.1 - 0.0073 16.3 0.4 0.0082 16.1 0.4 1.2 1 0 0 1 1 1 1 Zinc-ribbon DZR PF12773.7 AIC14724.1 - 0.018 15.0 0.9 0.042 13.9 0.9 1.6 1 1 0 1 1 1 0 Double zinc ribbon Lar_restr_allev PF14354.6 AIC14724.1 - 0.029 14.7 1.2 0.043 14.2 1.2 1.3 1 0 0 1 1 1 0 Restriction alleviation protein Lar AIM24 PF01987.17 AIC14725.1 - 3.2e-52 177.2 0.7 3.7e-52 177.1 0.7 1.0 1 0 0 1 1 1 1 Mitochondrial biogenesis AIM24 Lon_C PF05362.13 AIC14725.1 - 0.16 11.4 0.5 0.71 9.4 0.1 1.9 2 0 0 2 2 2 0 Lon protease (S16) C-terminal proteolytic domain PUA PF01472.20 AIC14726.1 - 1.5e-17 63.3 0.2 2.4e-17 62.7 0.2 1.3 1 0 0 1 1 1 1 PUA domain SH3_2 PF07653.17 AIC14726.1 - 0.12 12.0 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain HTH_24 PF13412.6 AIC14727.1 - 1.3e-07 31.1 0.5 3.2e-07 29.8 0.5 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC14727.1 - 4.2e-05 23.3 0.6 0.0001 22.1 0.6 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_IclR PF09339.10 AIC14727.1 - 0.095 12.5 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_28 PF13518.6 AIC14727.1 - 0.12 12.6 0.0 0.38 10.9 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_8 PF02954.19 AIC14727.1 - 0.12 12.2 0.1 0.33 10.8 0.1 1.7 1 1 0 1 1 1 0 Bacterial regulatory protein, Fis family HTH_23 PF13384.6 AIC14727.1 - 0.13 12.1 0.0 0.37 10.7 0.0 1.8 1 1 0 1 1 1 0 Homeodomain-like domain Proteasome PF00227.26 AIC14728.1 - 1.9e-48 164.5 0.1 2.3e-48 164.2 0.1 1.0 1 0 0 1 1 1 1 Proteasome subunit P5CR_dimer PF14748.6 AIC14728.1 - 0.025 14.8 0.2 0.055 13.7 0.2 1.5 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation RnfC_N PF13375.6 AIC14728.1 - 0.064 13.2 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain HATPase_c_3 PF13589.6 AIC14729.1 - 5.9e-13 48.8 0.0 1.3e-12 47.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 AIC14729.1 - 0.078 13.5 0.0 0.23 12.0 0.0 1.8 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Copper-bind PF00127.20 AIC14730.1 - 3.2e-08 33.9 0.0 4.3e-08 33.5 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC14730.1 - 8.6e-06 25.8 0.0 1.9e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 Cupredoxin-like domain eRF1_2 PF03464.15 AIC14732.1 - 1.3e-35 122.6 0.0 4.1e-35 121.0 0.0 1.8 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.15 AIC14732.1 - 9e-18 64.8 0.2 2.1e-17 63.6 0.2 1.7 1 0 0 1 1 1 1 eRF1 domain 3 acVLRF1 PF18859.1 AIC14732.1 - 3.1e-15 56.6 0.0 5.4e-15 55.8 0.0 1.4 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 AIC14732.1 - 6.8e-13 49.1 0.1 4.5e-12 46.4 0.0 2.3 3 0 0 3 3 3 1 Bacterial archaeo-eukaryotic release factor family 10 eRF1_1 PF03463.15 AIC14732.1 - 1.2e-10 41.5 0.0 2e-10 40.8 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 1 Zn-ribbon_8 PF09723.10 AIC14732.1 - 0.0049 16.9 1.2 0.011 15.9 0.4 2.0 2 0 0 2 2 2 1 Zinc ribbon domain HypA PF01155.19 AIC14732.1 - 0.0086 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA YrbL-PhoP_reg PF10707.9 AIC14732.1 - 0.044 13.3 0.2 0.14 11.6 0.0 1.9 3 0 0 3 3 3 0 PhoP regulatory network protein YrbL CBS PF00571.28 AIC14733.1 - 3.1e-17 62.7 1.5 3.6e-11 43.3 0.1 2.3 2 0 0 2 2 2 2 CBS domain HTH_3 PF01381.22 AIC14733.1 - 9e-13 48.1 0.4 2e-12 47.0 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_31 PF13560.6 AIC14733.1 - 3.7e-11 43.2 0.0 5.8e-11 42.6 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 AIC14733.1 - 7.4e-10 38.7 0.1 1.5e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 AIC14733.1 - 0.00043 20.1 0.0 0.00071 19.4 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain CoA_binding_2 PF13380.6 AIC14733.1 - 0.0026 18.2 0.1 0.0055 17.2 0.1 1.5 1 1 0 1 1 1 1 CoA binding domain MqsA_antitoxin PF15731.5 AIC14733.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.5 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA YdaS_antitoxin PF15943.5 AIC14733.1 - 0.085 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT BacA PF02673.18 AIC14735.1 - 1.4e-68 231.4 15.8 1.6e-68 231.2 15.8 1.0 1 0 0 1 1 1 1 Bacitracin resistance protein BacA Tmemb_170 PF10190.9 AIC14735.1 - 5 7.5 14.7 0.25 11.7 0.5 3.4 3 1 1 4 4 4 0 Putative transmembrane protein 170 Gp_dh_N PF00044.24 AIC14737.1 - 6.7e-06 26.4 0.0 7.9e-05 22.9 0.0 2.6 3 0 0 3 3 3 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain DapB_N PF01113.20 AIC14737.1 - 1.5e-05 25.1 0.2 3.5e-05 23.9 0.2 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Gp_dh_C PF02800.20 AIC14737.1 - 0.01 15.4 0.0 0.079 12.6 0.0 2.3 2 0 0 2 2 2 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain F420_oxidored PF03807.17 AIC14737.1 - 0.022 15.3 0.4 0.15 12.7 0.4 2.2 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 AIC14737.1 - 0.045 14.0 0.0 0.094 13.0 0.0 1.5 1 0 0 1 1 1 0 TrkA-N domain NAD_binding_3 PF03447.16 AIC14737.1 - 0.07 13.8 0.1 0.17 12.5 0.1 1.7 1 0 0 1 1 1 0 Homoserine dehydrogenase, NAD binding domain GATase PF00117.28 AIC14738.1 - 5.6e-54 182.8 0.0 6.9e-54 182.5 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIC14738.1 - 1.2e-10 41.6 0.1 2.5e-10 40.5 0.1 1.5 1 1 0 1 1 1 1 Peptidase C26 Glycos_transf_3 PF00591.21 AIC14739.1 - 1.4e-77 260.7 1.2 1.4e-77 260.7 1.2 1.5 2 0 0 2 2 2 1 Glycosyl transferase family, a/b domain Glycos_trans_3N PF02885.17 AIC14739.1 - 5.5e-16 58.2 2.0 1.1e-15 57.2 2.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family, helical bundle domain Acyl_transf_1 PF00698.21 AIC14739.1 - 0.051 13.1 0.1 0.088 12.3 0.1 1.4 1 0 0 1 1 1 0 Acyl transferase domain Ribosomal_L12_N PF16320.5 AIC14739.1 - 0.086 12.6 4.3 0.25 11.1 4.3 1.8 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain Rad51 PF08423.11 AIC14740.1 - 5.1e-85 284.8 0.0 6.8e-85 284.4 0.0 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AIC14740.1 - 2e-10 40.6 0.1 3.2e-10 39.9 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 AIC14740.1 - 3.1e-10 39.8 0.2 7e-10 38.6 0.0 1.7 2 0 0 2 2 2 1 KaiC HHH_5 PF14520.6 AIC14740.1 - 3.3e-09 37.2 0.5 8.5e-09 35.9 0.5 1.8 1 0 0 1 1 1 1 Helix-hairpin-helix domain DUF4332 PF14229.6 AIC14740.1 - 0.0053 17.0 0.1 0.018 15.3 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4332) Cdd1 PF11731.8 AIC14740.1 - 0.0071 16.6 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 1 Pathogenicity locus DNA_pol_lambd_f PF10391.9 AIC14740.1 - 0.0089 15.8 0.0 0.025 14.4 0.0 1.8 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda AAA PF00004.29 AIC14740.1 - 0.099 13.1 0.1 0.54 10.7 0.0 2.2 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Auto_anti-p27 PF06677.12 AIC14741.1 - 0.081 13.1 2.1 2 8.7 0.1 2.3 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) TMPIT PF07851.13 AIC14742.1 - 0.0013 18.0 1.1 0.0013 18.0 1.1 2.1 2 0 0 2 2 2 1 TMPIT-like protein UPF0184 PF03670.13 AIC14742.1 - 0.068 13.6 4.0 0.53 10.7 0.0 3.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) UPF0228 PF05727.11 AIC14742.1 - 0.11 12.4 2.8 0.39 10.5 0.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0228) DUF2408 PF10303.9 AIC14742.1 - 0.13 12.9 12.9 0.029 14.9 5.2 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2408) NPV_P10 PF05531.12 AIC14742.1 - 0.21 12.1 6.2 1.9 9.0 1.1 3.6 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DASH_Duo1 PF08651.10 AIC14742.1 - 0.27 11.0 2.6 1.1 9.1 0.8 2.7 3 0 0 3 3 3 0 DASH complex subunit Duo1 DUF16 PF01519.16 AIC14742.1 - 1.1 9.8 11.7 4.5 7.8 1.8 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.12 AIC14742.1 - 1.1 9.3 15.3 1.4 8.9 2.5 3.3 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 AIC14742.1 - 1.2 8.7 14.6 7.7 6.0 14.6 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit FUSC PF04632.12 AIC14742.1 - 1.3 7.5 6.1 1.6 7.1 6.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family NEMO PF11577.8 AIC14742.1 - 7 6.7 11.3 2.1 8.4 0.9 3.4 3 2 0 3 3 3 0 NF-kappa-B essential modulator NEMO DUF3138 PF11336.8 AIC14742.1 - 7.3 5.1 5.4 12 4.3 5.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3138) APG6_N PF17675.1 AIC14742.1 - 9.6 6.7 14.9 1.1e+03 0.1 15.1 2.4 1 1 0 1 1 1 0 Apg6 coiled-coil region PHZA_PHZB PF03284.13 AIC14743.1 - 0.21 11.2 0.0 0.27 10.8 0.0 1.1 1 0 0 1 1 1 0 Phenazine biosynthesis protein A/B IGPD PF00475.18 AIC14744.1 - 0.0049 17.2 0.0 0.0053 17.1 0.0 1.1 1 0 0 1 1 1 1 Imidazoleglycerol-phosphate dehydratase Trp_syntA PF00290.20 AIC14745.1 - 8.1e-88 293.6 0.1 9.2e-88 293.4 0.1 1.0 1 0 0 1 1 1 1 Tryptophan synthase alpha chain His_biosynth PF00977.21 AIC14745.1 - 1.7e-06 27.7 0.0 2.8e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.17 AIC14745.1 - 9.6e-05 21.9 0.2 0.00072 19.1 0.0 2.1 2 0 0 2 2 2 1 PcrB family Ribul_P_3_epim PF00834.19 AIC14745.1 - 0.00061 19.2 0.0 0.0012 18.3 0.0 1.5 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family NanE PF04131.14 AIC14745.1 - 0.0055 15.9 0.1 0.064 12.4 0.0 2.2 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase ThiG PF05690.14 AIC14745.1 - 0.0067 15.8 0.1 0.016 14.5 0.1 1.6 1 0 0 1 1 1 1 Thiazole biosynthesis protein ThiG IMPDH PF00478.25 AIC14745.1 - 0.011 14.8 0.1 0.16 10.9 0.0 2.1 2 0 0 2 2 2 0 IMP dehydrogenase / GMP reductase domain Peripla_BP_6 PF13458.6 AIC14745.1 - 0.021 14.5 0.1 0.088 12.5 0.0 1.9 1 1 1 2 2 2 0 Periplasmic binding protein DUF871 PF05913.11 AIC14745.1 - 0.16 11.1 0.0 0.38 9.9 0.0 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF871) PALP PF00291.25 AIC14746.1 - 5.3e-44 150.8 0.6 6.2e-44 150.6 0.6 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme IGPS PF00218.21 AIC14747.1 - 6.8e-67 225.3 0.9 7.8e-67 225.1 0.9 1.0 1 0 0 1 1 1 1 Indole-3-glycerol phosphate synthase NanE PF04131.14 AIC14747.1 - 0.00041 19.6 1.1 0.0015 17.7 1.1 1.9 1 1 0 1 1 1 1 Putative N-acetylmannosamine-6-phosphate epimerase QRPTase_C PF01729.19 AIC14747.1 - 0.005 16.6 0.0 0.009 15.8 0.0 1.4 1 1 0 1 1 1 1 Quinolinate phosphoribosyl transferase, C-terminal domain His_biosynth PF00977.21 AIC14747.1 - 0.0077 15.7 0.1 0.056 12.9 0.0 2.2 2 1 0 2 2 2 1 Histidine biosynthesis protein ThiG PF05690.14 AIC14747.1 - 0.033 13.5 3.3 0.31 10.3 0.0 2.5 2 1 0 2 2 2 0 Thiazole biosynthesis protein ThiG FMN_dh PF01070.18 AIC14747.1 - 0.049 12.7 0.4 0.12 11.4 0.4 1.6 1 1 0 1 1 1 0 FMN-dependent dehydrogenase HigB-like_toxin PF05015.13 AIC14747.1 - 0.15 12.5 0.0 0.27 11.7 0.0 1.4 1 0 0 1 1 1 0 RelE-like toxin of type II toxin-antitoxin system HigB AAA_22 PF13401.6 AIC14748.1 - 8.2e-12 45.6 0.0 2.5e-11 44.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC14748.1 - 1e-07 32.5 0.1 4.6e-07 30.4 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain TniB PF05621.11 AIC14748.1 - 5.2e-05 22.7 0.1 9.2e-05 21.9 0.1 1.3 1 0 0 1 1 1 1 Bacterial TniB protein AAA PF00004.29 AIC14748.1 - 7.1e-05 23.2 0.0 0.0002 21.8 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49_C PF17856.1 AIC14748.1 - 0.0025 17.9 4.1 0.019 15.1 0.0 3.3 3 1 0 3 3 3 1 TIP49 AAA-lid domain AAA_24 PF13479.6 AIC14748.1 - 0.0074 16.0 0.3 0.034 13.9 0.1 2.1 2 1 0 2 2 2 1 AAA domain NACHT PF05729.12 AIC14748.1 - 0.015 15.2 0.0 0.037 13.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 AIC14748.1 - 0.017 14.3 0.0 0.034 13.3 0.0 1.5 1 1 0 1 1 1 0 NB-ARC domain MarR_2 PF12802.7 AIC14748.1 - 0.045 13.6 1.1 0.24 11.3 0.2 2.4 2 0 0 2 2 2 0 MarR family AAA_30 PF13604.6 AIC14748.1 - 0.056 13.2 0.1 0.31 10.7 0.0 2.3 2 1 1 3 3 3 0 AAA domain AAA_assoc_2 PF16193.5 AIC14748.1 - 0.096 13.0 0.0 0.35 11.2 0.0 2.0 1 0 0 1 1 1 0 AAA C-terminal domain SRP54 PF00448.22 AIC14748.1 - 0.14 11.8 0.5 0.29 10.8 0.5 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 AIC14748.1 - 0.15 12.4 0.2 0.38 11.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain KfrA_N PF11740.8 AIC14748.1 - 0.17 12.6 0.5 1.1 10.0 0.2 2.2 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term TrmB PF01978.19 AIC14749.1 - 0.06 13.2 0.0 0.097 12.6 0.0 1.4 1 1 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB z-alpha PF02295.17 AIC14751.1 - 0.27 11.3 0.6 4.6 7.4 0.1 2.7 3 1 0 3 3 3 0 Adenosine deaminase z-alpha domain CTP_synth_N PF06418.14 AIC14752.1 - 6.4e-120 399.4 0.5 8e-120 399.1 0.5 1.1 1 0 0 1 1 1 1 CTP synthase N-terminus GATase PF00117.28 AIC14752.1 - 2.6e-48 164.3 0.0 4.3e-48 163.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIC14752.1 - 6.4e-09 35.9 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 CbiA PF01656.23 AIC14752.1 - 0.0049 16.9 0.0 0.016 15.3 0.0 1.7 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 AIC14752.1 - 0.0087 15.1 0.1 0.015 14.3 0.1 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NAD_kinase PF01513.21 AIC14753.1 - 2.2e-34 119.0 0.3 3e-34 118.5 0.3 1.2 1 0 0 1 1 1 1 ATP-NAD kinase HTH_24 PF13412.6 AIC14753.1 - 0.00062 19.3 0.0 0.0013 18.2 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIC14753.1 - 0.001 18.9 0.0 0.0021 17.9 0.0 1.6 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 AIC14753.1 - 0.0014 19.1 0.1 0.0033 17.9 0.1 1.7 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 AIC14753.1 - 0.0027 17.6 0.2 0.0055 16.6 0.2 1.4 1 0 0 1 1 1 1 MarR family RNA_pol_Rpc34 PF05158.12 AIC14753.1 - 0.0096 15.3 0.1 0.013 14.9 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HTH_9 PF08221.11 AIC14753.1 - 0.092 12.9 0.0 0.22 11.7 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_IclR PF09339.10 AIC14753.1 - 0.098 12.5 0.2 0.29 10.9 0.2 1.8 1 1 1 2 2 2 0 IclR helix-turn-helix domain PfkB PF00294.24 AIC14754.1 - 1.7e-09 37.4 0.0 3.3e-09 36.5 0.0 1.4 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 AIC14754.1 - 0.042 13.2 0.0 0.054 12.9 0.0 1.2 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase Ribosomal_S26e PF01283.19 AIC14755.1 - 2e-22 79.6 0.6 2.5e-22 79.3 0.6 1.1 1 0 0 1 1 1 1 Ribosomal protein S26e zf-ribbon_3 PF13248.6 AIC14755.1 - 0.019 14.4 2.2 0.037 13.4 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Lar_restr_allev PF14354.6 AIC14755.1 - 0.025 14.9 0.4 0.49 10.8 0.0 2.1 1 1 1 2 2 2 0 Restriction alleviation protein Lar HlyD PF00529.20 AIC14755.1 - 0.04 13.8 0.0 0.053 13.4 0.0 1.2 1 0 0 1 1 1 0 HlyD membrane-fusion protein of T1SS zf-dskA_traR PF01258.17 AIC14755.1 - 0.049 13.6 0.6 3.2 7.8 0.0 2.3 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger Auto_anti-p27 PF06677.12 AIC14755.1 - 0.062 13.5 1.2 10 6.4 0.1 2.3 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) CDP-OH_P_transf PF01066.21 AIC14756.1 - 3.1e-09 37.5 1.7 3.1e-09 37.5 1.7 2.1 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase MFS_MOT1 PF16983.5 AIC14756.1 - 0.0089 16.4 3.9 0.0089 16.4 3.9 2.0 3 0 0 3 3 3 1 Molybdate transporter of MFS superfamily Response_reg PF00072.24 AIC14758.1 - 2.4e-14 53.5 0.2 2.6e-13 50.1 0.2 2.1 1 1 0 1 1 1 1 Response regulator receiver domain DUF3567 PF12091.8 AIC14758.1 - 0.098 12.8 0.1 0.42 10.8 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3567) HATPase_c PF02518.26 AIC14759.1 - 9.7e-24 84.0 0.0 1.7e-23 83.3 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MASE3 PF17159.4 AIC14759.1 - 4.4e-14 52.7 17.3 2.2e-13 50.4 17.3 1.9 1 1 0 1 1 1 1 Membrane-associated sensor domain HisKA PF00512.25 AIC14759.1 - 1.2e-12 47.7 0.2 4.7e-12 45.8 0.1 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain YtpI PF14007.6 AIC14759.1 - 0.12 12.5 0.2 0.12 12.5 0.2 2.8 2 1 0 2 2 2 0 YtpI-like protein GSDH PF07995.11 AIC14760.1 - 9.9e-45 153.3 0.1 1.2e-44 153.0 0.1 1.1 1 0 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Aldolase_II PF00596.21 AIC14761.1 - 5.4e-32 111.2 0.5 6.1e-32 111.1 0.5 1.0 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain ATP-synt_F PF01990.17 AIC14762.1 - 1.3e-15 57.4 0.1 1.4e-15 57.4 0.1 1.0 1 0 0 1 1 1 1 ATP synthase (F/14-kDa) subunit SIT PF15330.6 AIC14764.1 - 0.011 16.2 0.2 0.011 16.1 0.2 1.1 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT FeoB_associated PF12669.7 AIC14764.1 - 0.15 12.5 0.2 0.15 12.5 0.2 1.3 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein SnoaL PF07366.12 AIC14765.1 - 5.7e-33 113.4 0.0 6.7e-33 113.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like polyketide cyclase SnoaL_2 PF12680.7 AIC14765.1 - 1.5e-19 70.5 0.0 1.9e-19 70.2 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIC14765.1 - 0.056 13.9 0.0 0.075 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4440) PrgI PF12666.7 AIC14766.1 - 0.0025 18.5 0.1 0.0028 18.3 0.1 1.0 1 0 0 1 1 1 1 PrgI family protein Peptidase_U4 PF03419.13 AIC14766.1 - 0.0065 15.8 0.4 0.0073 15.6 0.4 1.0 1 0 0 1 1 1 1 Sporulation factor SpoIIGA MWFE PF15879.5 AIC14766.1 - 0.13 12.5 2.0 0.6 10.3 0.0 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase MWFE subunit LapA_dom PF06305.11 AIC14766.1 - 1.2 9.0 4.7 12 5.8 0.0 2.2 1 1 1 2 2 2 0 Lipopolysaccharide assembly protein A domain DnaJ PF00226.31 AIC14767.1 - 1.2e-26 92.6 3.3 1.8e-26 92.0 0.6 2.0 2 0 0 2 2 2 1 DnaJ domain DUF1764 PF08576.10 AIC14767.1 - 0.1 13.5 0.2 0.14 13.1 0.2 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) MazG-like PF12643.7 AIC14767.1 - 0.19 12.0 1.0 3 8.1 0.0 2.6 2 1 0 2 2 2 0 MazG-like family DUF3273 PF11677.8 AIC14768.1 - 0.72 9.1 8.0 0.049 13.0 3.2 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3273) TMCO5 PF14992.6 AIC14768.1 - 3.1 7.3 4.2 10 5.6 0.6 2.1 2 0 0 2 2 2 0 TMCO5 family DUF4342 PF14242.6 AIC14768.1 - 8.7 6.4 7.4 0.44 10.6 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) Polyketide_cyc2 PF10604.9 AIC14769.1 - 6.1e-16 59.0 0.1 6.8e-16 58.8 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 AIC14769.1 - 4.2e-07 30.2 0.1 5e-07 30.0 0.1 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc PF03364.20 AIC14769.1 - 3.8e-06 27.1 0.0 4.7e-06 26.8 0.0 1.2 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Collectrin PF16959.5 AIC14771.1 - 0.44 10.3 1.6 0.51 10.1 1.6 1.1 1 0 0 1 1 1 0 Renal amino acid transporter APG6_N PF17675.1 AIC14772.1 - 1.5e-06 28.8 20.1 0.0082 16.7 4.2 2.3 1 1 1 2 2 2 2 Apg6 coiled-coil region YabA PF06156.13 AIC14772.1 - 8.2e-05 23.2 9.7 0.0081 16.8 1.5 2.6 1 1 2 3 3 3 2 Initiation control protein YabA CENP-F_leu_zip PF10473.9 AIC14772.1 - 0.00027 21.0 10.7 0.028 14.5 1.0 2.2 2 0 0 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Csm1_N PF18504.1 AIC14772.1 - 0.0006 20.1 9.9 0.0036 17.6 0.3 3.3 2 2 1 3 3 3 1 Csm1 N-terminal domain ATG16 PF08614.11 AIC14772.1 - 0.00061 20.1 17.4 0.0022 18.3 16.6 1.8 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) ZapB PF06005.12 AIC14772.1 - 0.00095 19.6 17.9 0.13 12.7 7.1 3.6 1 1 2 3 3 3 2 Cell division protein ZapB GAS PF13851.6 AIC14772.1 - 0.0019 17.6 7.8 0.0019 17.6 7.8 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.21 AIC14772.1 - 0.0022 18.0 14.1 0.27 11.4 5.5 3.8 2 2 1 3 3 3 2 bZIP transcription factor DUF2570 PF10828.8 AIC14772.1 - 0.0032 17.3 9.4 0.89 9.4 0.1 2.8 1 1 1 2 2 2 2 Protein of unknown function (DUF2570) DUF848 PF05852.11 AIC14772.1 - 0.0049 17.0 2.6 0.0049 17.0 2.6 2.0 1 1 1 2 2 2 1 Gammaherpesvirus protein of unknown function (DUF848) HALZ PF02183.18 AIC14772.1 - 0.0053 16.9 21.2 0.42 10.9 0.5 5.3 3 2 2 6 6 5 2 Homeobox associated leucine zipper TMF_DNA_bd PF12329.8 AIC14772.1 - 0.0083 16.1 16.3 0.14 12.2 0.7 3.0 2 1 1 3 3 3 2 TATA element modulatory factor 1 DNA binding Cep57_CLD_2 PF14197.6 AIC14772.1 - 0.012 15.7 14.7 0.41 10.8 4.9 3.5 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 TMF_TATA_bd PF12325.8 AIC14772.1 - 0.012 15.8 15.1 3.9 7.7 15.1 2.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CtIP_N PF10482.9 AIC14772.1 - 0.012 15.6 11.4 0.83 9.7 6.4 3.0 1 1 1 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain DUF2353 PF09789.9 AIC14772.1 - 0.014 14.8 3.9 0.021 14.2 3.9 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) DivIC PF04977.15 AIC14772.1 - 0.017 14.9 18.5 0.1 12.4 7.3 3.3 2 1 1 3 3 3 0 Septum formation initiator CEP63 PF17045.5 AIC14772.1 - 0.02 14.8 1.5 0.02 14.8 1.5 2.2 1 1 0 2 2 2 0 Centrosomal protein of 63 kDa Takusan PF04822.13 AIC14772.1 - 0.024 14.5 2.8 0.097 12.6 0.1 2.6 2 2 0 2 2 2 0 Takusan Lebercilin PF15619.6 AIC14772.1 - 0.024 14.3 8.0 0.78 9.4 0.5 2.3 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF4686 PF15742.5 AIC14772.1 - 0.036 13.2 11.3 0.72 8.9 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) CENP-H PF05837.12 AIC14772.1 - 0.042 14.2 17.0 0.26 11.7 5.1 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FlaC_arch PF05377.11 AIC14772.1 - 0.043 14.2 6.7 1.2 9.6 1.8 3.7 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) HAP1_N PF04849.13 AIC14772.1 - 0.044 13.0 12.9 0.86 8.7 5.4 2.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region KASH_CCD PF14662.6 AIC14772.1 - 0.05 13.4 14.8 0.086 12.7 8.3 2.4 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 AIC14772.1 - 0.061 13.4 15.2 0.84 9.7 2.6 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding bZIP_2 PF07716.15 AIC14772.1 - 0.075 13.1 21.0 0.55 10.3 0.8 4.5 2 2 3 5 5 4 0 Basic region leucine zipper NYD-SP28_assoc PF14775.6 AIC14772.1 - 0.11 12.6 7.0 31 4.8 0.0 4.1 3 1 0 3 3 3 0 Sperm tail C-terminal domain Rootletin PF15035.6 AIC14772.1 - 0.12 12.4 13.8 1.5 8.8 4.3 2.6 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Phage_GP20 PF06810.11 AIC14772.1 - 0.12 12.1 13.0 0.91 9.3 0.5 2.7 1 1 1 2 2 2 0 Phage minor structural protein GP20 MscS_porin PF12795.7 AIC14772.1 - 0.13 11.8 21.7 0.099 12.2 14.4 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain DUF4472 PF14739.6 AIC14772.1 - 0.13 13.0 14.0 0.24 12.1 2.5 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) TSC22 PF01166.18 AIC14772.1 - 0.13 12.6 7.6 16 5.9 2.5 4.0 1 1 2 3 3 3 0 TSC-22/dip/bun family Med21 PF11221.8 AIC14772.1 - 0.14 12.4 0.4 0.14 12.4 0.4 3.0 1 1 1 2 2 1 0 Subunit 21 of Mediator complex DUF4201 PF13870.6 AIC14772.1 - 0.14 11.9 10.2 2.2 8.0 1.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) BST2 PF16716.5 AIC14772.1 - 0.14 12.7 16.3 0.81 10.3 1.1 3.1 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 HMMR_C PF15908.5 AIC14772.1 - 0.14 12.4 8.3 0.77 10.0 1.6 2.4 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Tup_N PF08581.10 AIC14772.1 - 0.21 11.9 5.7 19 5.7 3.7 2.8 2 1 0 2 2 2 0 Tup N-terminal GIT_CC PF16559.5 AIC14772.1 - 0.23 11.4 10.4 0.58 10.1 0.3 3.7 2 2 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor V_ATPase_I PF01496.19 AIC14772.1 - 0.23 9.3 3.1 0.28 9.0 3.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIVA PF05103.13 AIC14772.1 - 0.31 11.1 14.0 0.39 10.8 8.8 2.2 1 1 1 2 2 2 0 DivIVA protein Fez1 PF06818.15 AIC14772.1 - 0.35 11.3 11.4 2.3 8.6 11.4 1.9 1 1 0 1 1 1 0 Fez1 FapA PF03961.13 AIC14772.1 - 0.41 9.2 5.5 0.65 8.5 5.5 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A Fungal_TACC PF12709.7 AIC14772.1 - 0.44 11.0 8.7 18 5.8 3.2 3.4 2 2 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins PRKG1_interact PF15898.5 AIC14772.1 - 0.44 11.5 13.2 1.2 10.1 2.7 3.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 AIC14772.1 - 0.5 10.4 22.7 14 5.8 11.7 3.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Nnf1 PF03980.14 AIC14772.1 - 0.55 10.6 16.3 4.4 7.7 5.8 3.7 1 1 2 3 3 3 0 Nnf1 DUF4618 PF15397.6 AIC14772.1 - 0.66 9.4 7.8 0.47 9.8 2.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) Wtap PF17098.5 AIC14772.1 - 0.68 9.8 14.8 0.08 12.9 3.5 2.6 2 1 0 2 2 2 0 WTAP/Mum2p family Leu_zip PF15294.6 AIC14772.1 - 1 8.8 11.2 2.9 7.4 5.6 2.3 1 1 1 2 2 2 0 Leucine zipper DUF4795 PF16043.5 AIC14772.1 - 1 8.9 9.3 0.78 9.3 2.9 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) DUF724 PF05266.14 AIC14772.1 - 1 9.1 9.6 0.22 11.3 4.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) TolA_bind_tri PF16331.5 AIC14772.1 - 1.3 9.1 8.2 7.5 6.7 2.3 3.3 2 2 1 3 3 3 0 TolA binding protein trimerisation Spc7 PF08317.11 AIC14772.1 - 1.3 7.8 15.7 0.76 8.6 5.6 2.0 1 1 0 2 2 2 0 Spc7 kinetochore protein Fib_alpha PF08702.10 AIC14772.1 - 1.4 9.1 5.7 4.3 7.5 4.3 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Uso1_p115_C PF04871.13 AIC14772.1 - 1.6 9.1 23.5 1.6 9.1 8.4 2.5 1 1 1 2 2 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region YlqD PF11068.8 AIC14772.1 - 1.7 9.1 11.8 31 5.0 10.6 2.1 1 1 0 1 1 1 0 YlqD protein DUF3450 PF11932.8 AIC14772.1 - 1.8 7.8 20.4 2.9 7.1 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HAUS-augmin3 PF14932.6 AIC14772.1 - 2.9 7.4 15.6 3 7.3 4.8 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Prefoldin_2 PF01920.20 AIC14772.1 - 3 7.8 11.7 6.4 6.8 0.2 3.1 2 2 1 3 3 3 0 Prefoldin subunit Seryl_tRNA_N PF02403.22 AIC14772.1 - 3.1 8.1 13.2 14 6.0 0.4 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DMPK_coil PF08826.10 AIC14772.1 - 3.1 8.0 11.1 0.33 11.1 3.9 2.8 3 0 0 3 3 2 0 DMPK coiled coil domain like BLOC1_2 PF10046.9 AIC14772.1 - 3.3 8.1 10.4 0.59 10.5 2.3 2.5 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SOGA PF11365.8 AIC14772.1 - 3.4 8.8 9.1 24 6.1 2.9 3.1 1 1 3 4 4 3 0 Protein SOGA Atg14 PF10186.9 AIC14772.1 - 3.6 6.6 8.0 4 6.4 7.0 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 AIC14772.1 - 3.9 7.5 11.2 40 4.2 11.2 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PikAIV_N PF18605.1 AIC14772.1 - 5.2 6.7 11.9 0.52 9.9 0.2 4.1 4 0 0 4 4 4 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Mod_r PF07200.13 AIC14772.1 - 6.1 6.9 16.8 5.1 7.2 5.1 2.5 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein EMP24_GP25L PF01105.24 AIC14772.1 - 9 6.2 7.3 1.8 8.5 0.4 2.1 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Lectin_N PF03954.14 AIC14772.1 - 9 6.0 7.4 20 4.9 1.8 2.5 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain CC2-LZ PF16516.5 AIC14772.1 - 9.1 6.7 14.1 7.2 7.0 0.2 3.0 1 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Zn_ribbon_17 PF17120.5 AIC14773.1 - 0.054 13.1 2.1 0.071 12.7 2.1 1.2 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type C1_1 PF00130.22 AIC14773.1 - 0.057 13.3 3.8 0.081 12.8 3.8 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CD45 PF12567.8 AIC14773.1 - 0.066 13.2 1.1 0.085 12.8 1.1 1.2 1 0 0 1 1 1 0 Leukocyte receptor CD45 zf-U1 PF06220.12 AIC14773.1 - 0.08 12.7 0.6 0.14 11.9 0.6 1.5 1 0 0 1 1 1 0 U1 zinc finger Prok-RING_1 PF14446.6 AIC14773.1 - 0.096 12.6 2.9 0.14 12.1 2.9 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 PHD PF00628.29 AIC14773.1 - 0.17 11.8 4.1 0.23 11.4 4.1 1.2 1 0 0 1 1 1 0 PHD-finger zf-H2C2_2 PF13465.6 AIC14773.1 - 8 7.1 6.9 18 6.0 0.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain PDH PF02153.17 AIC14774.1 - 4.2e-18 65.3 0.4 5.9e-18 64.8 0.4 1.2 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_binding_2 PF03446.15 AIC14774.1 - 2.3e-06 27.9 0.3 4.2e-06 27.0 0.1 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 AIC14774.1 - 1.7e-05 25.3 0.4 0.00012 22.6 0.2 2.4 1 1 1 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent CoA_binding_2 PF13380.6 AIC14774.1 - 2.8e-05 24.6 0.2 7e-05 23.3 0.2 1.7 1 0 0 1 1 1 1 CoA binding domain Rossmann-like PF10727.9 AIC14774.1 - 0.00077 19.3 0.5 0.0022 17.9 0.5 1.9 1 1 0 1 1 1 1 Rossmann-like domain CoA_binding PF02629.19 AIC14774.1 - 0.0012 19.4 0.9 0.0023 18.6 0.3 1.8 2 0 0 2 2 2 1 CoA binding domain 4HFCP_synth PF04476.13 AIC14774.1 - 0.0018 18.0 0.4 2 8.1 0.0 2.9 2 1 1 3 3 3 2 4-HFC-P synthase DapB_N PF01113.20 AIC14774.1 - 0.002 18.3 0.1 0.0049 17.0 0.1 1.8 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_Gly3P_dh_N PF01210.23 AIC14774.1 - 0.0026 17.7 0.4 0.0026 17.7 0.4 1.9 1 1 1 2 2 2 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus IlvN PF07991.12 AIC14774.1 - 0.0087 15.6 0.1 0.081 12.5 0.1 2.1 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain GFO_IDH_MocA PF01408.22 AIC14774.1 - 0.011 16.6 0.7 0.09 13.6 0.4 2.6 2 2 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold ApbA_C PF08546.11 AIC14774.1 - 0.015 15.5 0.0 0.036 14.2 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 AIC14774.1 - 0.068 12.8 0.3 1.1 8.9 0.2 2.3 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Ldh_1_N PF00056.23 AIC14774.1 - 0.11 12.6 0.8 3.1 7.9 0.7 2.6 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain Semialdhyde_dh PF01118.24 AIC14774.1 - 0.15 12.5 1.4 3.8 8.0 1.4 2.5 1 1 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain Aminotran_1_2 PF00155.21 AIC14775.1 - 6.5e-52 176.9 0.0 8.4e-52 176.5 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AIC14775.1 - 5.8e-10 38.7 0.0 8.8e-10 38.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AIC14775.1 - 4.6e-09 35.3 0.0 6.5e-09 34.8 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme CM_2 PF01817.21 AIC14775.1 - 7.5e-08 32.6 3.3 1.7e-07 31.4 3.3 1.7 1 0 0 1 1 1 1 Chorismate mutase type II Beta_elim_lyase PF01212.21 AIC14775.1 - 3.9e-05 23.1 0.0 9e-05 21.9 0.0 1.5 2 0 0 2 2 2 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AIC14775.1 - 0.00023 20.6 1.0 0.00049 19.5 0.0 1.8 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Chorismate_synt PF01264.21 AIC14776.1 - 9.9e-137 455.0 0.0 1.1e-136 454.8 0.0 1.0 1 0 0 1 1 1 1 Chorismate synthase EPSP_synthase PF00275.20 AIC14777.1 - 3.9e-107 358.5 0.1 4.6e-107 358.3 0.1 1.0 1 0 0 1 1 1 1 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) GHMP_kinases_N PF00288.26 AIC14778.1 - 2.6e-10 40.4 0.7 2.6e-10 40.4 0.7 2.3 3 0 0 3 3 3 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AIC14778.1 - 8.5e-06 26.1 0.1 2.8e-05 24.4 0.1 1.9 2 0 0 2 2 2 1 GHMP kinases C terminal Shikimate_dh_N PF08501.11 AIC14779.1 - 3.7e-31 107.2 0.0 9.9e-31 105.8 0.0 1.8 1 0 0 1 1 1 1 Shikimate dehydrogenase substrate binding domain SDH_C PF18317.1 AIC14779.1 - 7.6e-14 51.2 0.5 1.5e-13 50.3 0.1 1.8 2 0 0 2 2 2 1 Shikimate 5'-dehydrogenase C-terminal domain Shikimate_DH PF01488.20 AIC14779.1 - 1.9e-08 34.4 0.0 3.7e-08 33.5 0.0 1.4 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 AIC14779.1 - 2e-05 24.9 0.3 4.5e-05 23.7 0.1 1.8 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 AIC14779.1 - 0.0052 17.3 0.6 0.012 16.2 0.6 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DHquinase_I PF01487.15 AIC14780.1 - 2.5e-51 175.1 0.0 2.8e-51 175.0 0.0 1.0 1 0 0 1 1 1 1 Type I 3-dehydroquinase zf-C2H2 PF00096.26 AIC14781.1 - 8.3e-06 26.0 0.3 1.4e-05 25.3 0.3 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC14781.1 - 0.00091 19.9 0.3 0.0014 19.3 0.3 1.3 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 AIC14781.1 - 0.0059 17.0 0.1 0.011 16.1 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 AIC14781.1 - 0.01 16.1 0.1 0.017 15.4 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AIC14781.1 - 0.024 14.6 4.2 0.073 13.1 4.2 1.8 1 1 0 1 1 1 0 C2H2-type zinc finger Pilin_N PF07790.11 AIC14782.1 - 0.028 15.3 0.2 0.051 14.5 0.2 1.5 1 1 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF3268 PF11672.8 AIC14783.1 - 0.041 14.2 0.1 0.062 13.6 0.1 1.3 1 0 0 1 1 1 0 zinc-finger-containing domain N6_N4_Mtase PF01555.18 AIC14784.1 - 5e-35 121.3 0.0 6e-35 121.0 0.0 1.1 1 0 0 1 1 1 1 DNA methylase Methyltransf_31 PF13847.6 AIC14784.1 - 3.3e-05 23.7 0.0 0.00036 20.4 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14784.1 - 6.5e-05 23.5 0.0 0.01 16.5 0.0 2.5 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC14784.1 - 0.00096 19.8 0.0 0.0032 18.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain CMAS PF02353.20 AIC14784.1 - 0.083 12.2 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase MethyltransfD12 PF02086.15 AIC14784.1 - 0.16 11.6 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 D12 class N6 adenine-specific DNA methyltransferase PP1c_bdg PF10488.9 AIC14785.1 - 0.015 14.8 0.0 0.017 14.6 0.0 1.1 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region DHQS PF01959.16 AIC14786.1 - 1.3e-106 356.5 0.7 1.6e-106 356.2 0.7 1.0 1 0 0 1 1 1 1 3-dehydroquinate synthase II Toprim PF01751.22 AIC14786.1 - 0.034 14.4 0.1 0.07 13.4 0.1 1.5 1 0 0 1 1 1 0 Toprim domain Helicase_RecD PF05127.14 AIC14786.1 - 0.056 13.3 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Helicase DeoC PF01791.9 AIC14787.1 - 2e-49 168.3 0.0 2.3e-49 168.1 0.0 1.0 1 0 0 1 1 1 1 DeoC/LacD family aldolase PEP_mutase PF13714.6 AIC14787.1 - 0.0049 16.4 0.2 0.13 11.7 0.2 2.1 1 1 1 2 2 2 1 Phosphoenolpyruvate phosphomutase ThiG PF05690.14 AIC14787.1 - 0.0092 15.3 0.6 0.0092 15.3 0.6 2.5 3 1 0 3 3 3 1 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 AIC14787.1 - 0.062 12.7 0.1 0.32 10.4 0.1 2.0 2 0 0 2 2 2 0 Histidine biosynthesis protein DUF561 PF04481.12 AIC14787.1 - 0.097 11.8 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF561) V4R PF02830.18 AIC14788.1 - 3.8e-09 36.4 0.6 6.1e-09 35.8 0.6 1.4 1 0 0 1 1 1 1 V4R domain AP_endonuc_2 PF01261.24 AIC14790.1 - 2.7e-33 115.2 0.0 3.2e-33 114.9 0.0 1.1 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel DUF5397 PF17375.2 AIC14790.1 - 0.12 12.1 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5397) DNA_primase_lrg PF04104.14 AIC14791.1 - 3.6e-28 98.7 0.0 6.9e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic and archaeal DNA primase, large subunit DNA_primase_S PF01896.19 AIC14792.1 - 6.7e-16 58.8 0.0 3.1e-15 56.7 0.0 2.1 2 2 0 2 2 2 1 DNA primase small subunit OrfB_Zn_ribbon PF07282.11 AIC14792.1 - 0.055 13.4 1.2 0.16 11.9 1.2 1.7 1 0 0 1 1 1 0 Putative transposase DNA-binding domain Zn-ribbon_8 PF09723.10 AIC14792.1 - 0.07 13.3 1.1 0.17 12.0 1.1 1.7 1 0 0 1 1 1 0 Zinc ribbon domain zf-piccolo PF05715.13 AIC14792.1 - 0.094 12.9 0.6 0.22 11.7 0.6 1.6 1 0 0 1 1 1 0 Piccolo Zn-finger UPF0182 PF03699.13 AIC14793.1 - 5.8e-38 130.6 10.3 6.5e-22 77.5 0.6 3.0 2 1 0 2 2 2 2 Uncharacterised protein family (UPF0182) DUF4179 PF13786.6 AIC14793.1 - 1.1 9.7 5.3 1.3 9.5 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4179) GATase PF00117.28 AIC14794.1 - 1.7e-21 76.8 0.0 2e-21 76.6 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIC14794.1 - 5.6e-11 42.6 0.0 2.2e-09 37.4 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 GATase_3 PF07685.14 AIC14794.1 - 0.098 12.2 0.1 0.2 11.3 0.0 1.5 1 1 1 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain TPR_16 PF13432.6 AIC14795.1 - 6.7e-14 52.3 11.1 7e-08 33.0 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 AIC14795.1 - 2.6e-13 49.2 12.4 3e-05 23.6 1.9 5.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 AIC14795.1 - 4.5e-13 48.3 6.1 0.001 19.1 1.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 AIC14795.1 - 1.3e-12 46.8 11.8 0.0031 17.5 2.2 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 AIC14795.1 - 1.1e-11 44.2 13.1 4.8e-07 29.4 0.3 3.6 5 0 0 5 5 5 2 TPR repeat TPR_17 PF13431.6 AIC14795.1 - 5.6e-10 38.9 6.8 0.00012 22.2 1.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 AIC14795.1 - 8.6e-10 38.6 3.1 6.9e-07 29.3 0.0 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 AIC14795.1 - 1.6e-09 38.1 7.2 0.00012 22.5 0.3 3.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 AIC14795.1 - 1.6e-08 34.7 8.4 9.7e-07 29.0 0.6 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 AIC14795.1 - 5.6e-08 33.0 8.9 0.0017 19.0 1.7 4.0 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 AIC14795.1 - 6.2e-07 29.0 4.9 0.19 11.8 0.0 4.1 4 1 0 4 4 4 3 Tetratricopeptide repeat Peptidase_C39_2 PF13529.6 AIC14795.1 - 0.00097 19.7 0.0 0.0027 18.3 0.0 1.8 1 1 0 1 1 1 1 Peptidase_C39 like family Peptidase_C39 PF03412.15 AIC14795.1 - 0.0025 17.6 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 Peptidase C39 family TPR_15 PF13429.6 AIC14795.1 - 0.0048 16.1 0.5 0.0078 15.5 0.5 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 AIC14795.1 - 0.0079 16.8 7.4 9.9 7.0 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 AIC14795.1 - 0.011 16.1 4.9 0.08 13.3 0.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 AIC14795.1 - 1.6 8.7 0.0 1.6 8.7 0.0 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 AIC14795.1 - 5.6 7.8 7.0 6.6 7.6 2.8 3.1 4 0 0 4 4 4 0 Sel1 repeat ABM PF03992.16 AIC14796.1 - 4.6e-18 65.1 0.0 7.1e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase Aldo_ket_red PF00248.21 AIC14800.1 - 4.1e-24 85.3 0.3 7.1e-22 77.9 0.3 2.5 1 1 0 1 1 1 1 Aldo/keto reductase family HTH_45 PF14947.6 AIC14802.1 - 2.2e-10 40.4 0.0 3e-10 39.9 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix Rio2_N PF09202.11 AIC14802.1 - 0.011 16.0 0.0 0.012 15.8 0.0 1.2 1 0 0 1 1 1 0 Rio2, N-terminal DUF4364 PF14277.6 AIC14802.1 - 0.04 13.7 0.0 0.044 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) HTH_34 PF13601.6 AIC14802.1 - 0.058 13.6 0.0 0.57 10.4 0.0 2.0 1 1 0 1 1 1 0 Winged helix DNA-binding domain HTH_46 PF15977.5 AIC14802.1 - 0.14 12.2 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding DUF4394 PF14339.6 AIC14803.1 - 0.0004 19.8 3.9 0.0012 18.3 3.3 2.2 1 1 0 1 1 1 1 Domain of unknown function (DUF4394) BChl_A PF02327.17 AIC14803.1 - 0.0064 15.3 1.2 0.03 13.1 0.1 2.0 2 0 0 2 2 2 1 Bacteriochlorophyll A protein Pep3_Vps18 PF05131.14 AIC14803.1 - 0.12 12.2 0.0 0.34 10.7 0.0 1.7 1 1 0 1 1 1 0 Pep3/Vps18/deep orange family PQQ_3 PF13570.6 AIC14803.1 - 0.32 11.5 6.6 0.48 11.0 0.2 4.0 6 0 0 6 6 6 0 PQQ-like domain LT-IIB PF06453.11 AIC14803.1 - 0.53 10.2 13.0 11 5.9 0.3 4.2 2 2 2 4 4 4 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) PQQ PF01011.21 AIC14803.1 - 0.65 10.0 5.1 3.3 7.8 0.1 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat Reprolysin_5 PF13688.6 AIC14805.1 - 0.00013 22.2 0.0 0.0002 21.6 0.0 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12 Metallopep PF12044.8 AIC14805.1 - 0.00061 18.5 0.0 0.00077 18.2 0.0 1.1 1 0 0 1 1 1 1 Putative peptidase family Reprolysin_3 PF13582.6 AIC14805.1 - 0.00062 20.3 0.7 0.001 19.6 0.7 1.3 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 AIC14805.1 - 0.0017 17.4 0.3 0.0026 16.7 0.3 1.3 1 0 0 1 1 1 1 Peptidase M66 Reprolysin PF01421.19 AIC14805.1 - 0.0081 16.1 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 Reprolysin (M12B) family zinc metalloprotease Peptidase_M10 PF00413.24 AIC14805.1 - 0.077 12.8 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 Matrixin Reprolysin_4 PF13583.6 AIC14805.1 - 0.077 12.6 0.2 0.17 11.5 0.1 1.6 2 0 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like DUF4953 PF16313.5 AIC14805.1 - 0.19 10.9 0.1 0.29 10.3 0.1 1.2 1 0 0 1 1 1 0 Met-zincin DcrB PF08786.11 AIC14806.1 - 0.0017 18.5 0.0 0.0022 18.1 0.0 1.2 1 0 0 1 1 1 1 DcrB PsbP PF01789.16 AIC14806.1 - 0.014 15.5 0.2 0.035 14.3 0.2 1.6 1 1 0 1 1 1 0 PsbP GtrA PF04138.14 AIC14806.1 - 0.12 12.6 0.8 0.2 11.9 0.8 1.3 1 0 0 1 1 1 0 GtrA-like protein BNR_4 PF15892.5 AIC14808.1 - 0.00067 19.1 0.9 1.1 8.5 0.1 2.6 2 1 0 2 2 2 2 BNR repeat-containing family member BNR_2 PF13088.6 AIC14808.1 - 0.0039 16.5 0.2 0.36 10.1 0.0 2.4 2 0 0 2 2 2 2 BNR repeat-like domain CHU_C PF13585.6 AIC14808.1 - 0.043 13.9 4.2 12 6.1 0.0 3.7 3 0 0 3 3 3 0 C-terminal domain of CHU protein family BNR PF02012.20 AIC14808.1 - 0.052 13.6 7.6 4.3 7.8 0.7 4.4 3 0 0 3 3 3 0 BNR/Asp-box repeat UbiA PF01040.18 AIC14809.1 - 1.3e-29 103.3 21.6 1.7e-29 102.9 21.6 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family AsnC_trans_reg PF01037.21 AIC14810.1 - 1.2e-09 37.9 0.0 1.4e-09 37.8 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain DUF2203 PF09969.9 AIC14811.1 - 1.2e-35 122.9 0.0 1.3e-35 122.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) AdoHcyase PF05221.17 AIC14811.1 - 0.11 11.6 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase Na_H_Exchanger PF00999.21 AIC14812.1 - 9.4e-63 212.3 48.2 1.2e-62 212.0 48.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family GDE_C PF06202.14 AIC14813.1 - 2.3e-36 125.6 0.1 4.9e-36 124.5 0.1 1.5 1 0 0 1 1 1 1 Amylo-alpha-1,6-glucosidase Bac_rhamnosid6H PF17389.2 AIC14813.1 - 3.3e-10 39.7 0.1 5.4e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Glyco_hydro_100 PF12899.7 AIC14813.1 - 5.1e-09 35.3 0.1 0.00061 18.6 0.0 2.2 2 0 0 2 2 2 2 Alkaline and neutral invertase Trehalase PF01204.18 AIC14813.1 - 2.7e-05 23.2 0.5 6e-05 22.1 0.1 1.6 2 0 0 2 2 2 1 Trehalase Glyco_hydro_36 PF17167.4 AIC14813.1 - 9.4e-05 21.3 0.3 0.00076 18.3 0.1 2.5 2 1 1 3 3 3 1 Glycosyl hydrolase 36 superfamily, catalytic domain DUF608 PF04685.13 AIC14813.1 - 0.0016 17.6 0.3 0.0061 15.8 0.1 1.9 2 0 0 2 2 2 1 Glycosyl-hydrolase family 116, catalytic region Type_III_YscG PF09477.10 AIC14813.1 - 0.026 14.6 0.0 0.081 13.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial type II secretion system chaperone protein (type_III_yscG) Osmo_MPGsynth PF09488.10 AIC14814.1 - 3.6e-145 483.5 0.0 4.1e-145 483.3 0.0 1.0 1 0 0 1 1 1 1 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) zf-C2HE PF16278.5 AIC14815.1 - 0.024 15.1 0.6 0.024 15.1 0.6 1.6 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger TF_Zn_Ribbon PF08271.12 AIC14815.1 - 0.037 13.5 5.7 0.065 12.8 5.7 1.4 1 0 0 1 1 1 0 TFIIB zinc-binding zf_UBZ PF18439.1 AIC14815.1 - 0.07 12.7 4.8 3.3 7.4 0.3 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Cytochrome_C7 PF14522.6 AIC14815.1 - 0.076 13.0 3.4 0.15 12.1 3.4 1.5 1 1 0 1 1 1 0 Cytochrome c7 and related cytochrome c PSCyt3 PF07627.11 AIC14815.1 - 0.099 12.9 0.3 0.12 12.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) CEBP_ZZ PF16366.5 AIC14815.1 - 0.11 12.8 3.7 0.14 12.4 3.7 1.2 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain C1_2 PF03107.16 AIC14815.1 - 0.21 12.0 6.8 0.3 11.5 6.6 1.4 1 1 0 1 1 1 0 C1 domain GSK-3_bind PF05350.12 AIC14815.1 - 0.45 9.8 1.7 0.49 9.7 1.7 1.1 1 0 0 1 1 1 0 Glycogen synthase kinase-3 binding UPF0086 PF01868.16 AIC14816.1 - 0.02 14.8 0.1 0.56 10.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function UPF0086 HCBP_related PF06594.11 AIC14816.1 - 0.054 13.4 0.3 1.8 8.5 0.1 2.3 2 0 0 2 2 2 0 Haemolysin-type calcium binding protein related domain DUF4147 PF13660.6 AIC14817.1 - 1e-77 260.8 1.7 1.6e-77 260.2 1.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4147) MOFRL PF05161.13 AIC14817.1 - 4.8e-33 113.6 2.5 9.7e-33 112.6 2.5 1.6 1 0 0 1 1 1 1 MOFRL family BPL_LplA_LipB PF03099.19 AIC14818.1 - 2.7e-15 56.4 0.0 4.7e-15 55.7 0.0 1.4 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family HTH_11 PF08279.12 AIC14818.1 - 2.1e-13 50.0 0.0 4.4e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 AIC14818.1 - 3e-06 26.7 0.0 6.1e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding BPL_LplA_LipB_2 PF16917.5 AIC14818.1 - 4.6e-06 26.3 1.1 5.2e-06 26.1 0.1 1.6 2 1 0 2 2 2 1 Biotin/lipoate A/B protein ligase family BPL_C PF02237.17 AIC14818.1 - 0.00015 21.6 0.2 0.00037 20.3 0.2 1.7 1 0 0 1 1 1 1 Biotin protein ligase C terminal domain HTH_AsnC-type PF13404.6 AIC14818.1 - 0.0033 17.2 0.1 0.0086 15.9 0.1 1.7 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_1 PF00126.27 AIC14818.1 - 0.0062 16.5 0.4 0.02 14.8 0.1 2.0 2 0 0 2 2 2 1 Bacterial regulatory helix-turn-helix protein, lysR family Fe_dep_repress PF01325.19 AIC14818.1 - 0.015 15.5 0.0 0.034 14.3 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Rrf2 PF02082.20 AIC14818.1 - 0.016 15.5 0.1 0.096 13.0 0.0 2.3 2 0 0 2 2 2 0 Transcriptional regulator TrmB PF01978.19 AIC14818.1 - 0.035 14.0 0.0 0.073 13.0 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_36 PF13730.6 AIC14818.1 - 0.05 13.6 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_10 PF04967.12 AIC14818.1 - 0.07 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 HTH DNA binding domain DUF2087 PF09860.9 AIC14819.1 - 0.0093 16.1 0.1 0.022 14.9 0.0 1.6 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2087) SYF2 PF08231.12 AIC14819.1 - 0.035 14.5 0.0 0.035 14.5 0.0 1.0 1 0 0 1 1 1 0 SYF2 splicing factor PUB_1 PF18486.1 AIC14819.1 - 0.084 12.7 0.0 0.12 12.2 0.0 1.3 1 1 0 1 1 1 0 PNGase/UBA- or UBX-containing domain a_DG1_N2 PF18424.1 AIC14819.1 - 0.14 12.3 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Alpha-Dystroglycan N-terminal domain 2 UBA_6 PF18039.1 AIC14819.1 - 0.14 12.1 0.1 0.29 11.1 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain MMR_HSR1_C PF08438.10 AIC14820.1 - 1.5e-33 115.7 0.0 4.6e-33 114.1 0.0 1.8 2 0 0 2 2 2 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 AIC14820.1 - 2.5e-20 72.7 0.0 1.5e-19 70.1 0.0 2.2 3 0 0 3 3 3 1 50S ribosome-binding GTPase TGS PF02824.21 AIC14820.1 - 4.6e-10 39.4 0.0 8.6e-10 38.5 0.0 1.4 1 0 0 1 1 1 1 TGS domain FeoB_N PF02421.18 AIC14820.1 - 1.2e-07 31.3 0.1 5.3e-06 26.1 0.4 2.8 3 0 0 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 AIC14820.1 - 0.00044 20.3 0.0 0.08 13.0 0.0 2.3 1 1 1 2 2 2 2 Dynamin family GTP_EFTU PF00009.27 AIC14820.1 - 0.025 14.1 0.1 3.3 7.2 0.0 2.6 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Imm51 PF15595.6 AIC14824.1 - 0.055 13.4 0.0 0.16 12.0 0.0 1.7 1 1 1 2 2 2 0 Immunity protein 51 DUF2171 PF09939.9 AIC14826.1 - 0.0054 17.0 0.0 0.0067 16.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2171) EFG_II PF14492.6 AIC14828.1 - 0.053 13.6 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Elongation Factor G, domain II zf-C3HC4_3 PF13920.6 AIC14828.1 - 0.06 13.2 2.2 0.11 12.4 2.2 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF2397 PF09660.10 AIC14828.1 - 0.11 11.3 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2397) zf-C2H2_2 PF12756.7 AIC14828.1 - 0.61 10.5 0.0 0.61 10.5 0.0 2.3 2 1 0 2 2 2 0 C2H2 type zinc-finger (2 copies) MEDS PF14417.6 AIC14829.1 - 6.5e-05 22.8 0.0 0.00062 19.6 0.0 2.1 1 1 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF3527 PF12043.8 AIC14829.1 - 0.018 14.6 0.0 0.026 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) CoA_binding_2 PF13380.6 AIC14830.1 - 1.7e-39 134.9 0.2 1.9e-39 134.7 0.2 1.0 1 0 0 1 1 1 1 CoA binding domain CoA_binding PF02629.19 AIC14830.1 - 6.7e-07 29.9 0.3 1.2e-06 29.1 0.1 1.5 2 0 0 2 2 2 1 CoA binding domain DUF4849 PF16141.5 AIC14830.1 - 0.35 10.1 2.0 1.1 8.4 1.0 1.9 1 1 1 2 2 2 0 Putative glycoside hydrolase Family 18, chitinase_18 HEPN PF05168.14 AIC14831.1 - 1.7e-05 24.9 1.3 3.6e-05 23.9 1.3 1.5 1 0 0 1 1 1 1 HEPN domain Collar PF07484.12 AIC14832.1 - 0.15 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Phage Tail Collar Domain SHOCT PF09851.9 AIC14833.1 - 5.5e-07 29.1 1.1 2.5e-06 27.0 0.4 2.2 2 0 0 2 2 2 1 Short C-terminal domain GRAM PF02893.20 AIC14833.1 - 5.8e-06 26.2 0.2 2.5e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 GRAM domain DUF4428 PF14471.6 AIC14833.1 - 0.0044 16.9 5.7 0.45 10.5 0.2 2.8 2 0 0 2 2 2 2 Domain of unknown function (DUF4428) Vps36_ESCRT-II PF11605.8 AIC14833.1 - 0.027 14.6 0.1 0.074 13.2 0.1 1.8 1 1 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 PH_TFIIH PF08567.11 AIC14833.1 - 0.037 14.3 0.2 1.7 9.1 0.0 2.6 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain DUF1272 PF06906.11 AIC14833.1 - 0.11 12.6 0.6 0.26 11.4 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) GvpG PF05120.12 AIC14833.1 - 0.13 12.3 0.9 0.23 11.5 0.1 1.8 2 0 0 2 2 2 0 Gas vesicle protein G Cytochrome_C7 PF14522.6 AIC14833.1 - 0.2 11.7 4.8 3.3 7.8 0.5 2.6 2 0 0 2 2 2 0 Cytochrome c7 and related cytochrome c Paired_CXXCH_1 PF09699.10 AIC14833.1 - 0.27 11.0 4.6 0.53 10.1 1.2 2.5 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Cytochrom_c3_2 PF14537.6 AIC14833.1 - 0.29 11.6 5.1 1.5 9.3 0.3 2.4 2 0 0 2 2 2 0 Cytochrome c3 DUF5300 PF17224.3 AIC14835.1 - 0.0016 18.7 0.0 0.0023 18.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5300) GATase_6 PF13522.6 AIC14836.1 - 3.9e-13 49.8 0.0 7e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AIC14836.1 - 2.6e-12 46.7 0.0 5.1e-12 45.8 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain Pribosyltran PF00156.27 AIC14836.1 - 1.3e-06 28.0 0.0 2.5e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain GATase_4 PF13230.6 AIC14836.1 - 1e-05 24.6 0.0 1.8e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II GATase_2 PF00310.21 AIC14836.1 - 0.001 17.9 0.0 0.046 12.4 0.0 2.5 3 0 0 3 3 3 1 Glutamine amidotransferases class-II AIRS_C PF02769.22 AIC14837.1 - 2e-46 158.0 1.0 3.6e-24 85.7 0.2 2.3 2 0 0 2 2 2 2 AIR synthase related protein, C-terminal domain AIRS PF00586.24 AIC14837.1 - 2.5e-39 133.8 1.1 1.6e-19 70.3 0.2 2.6 2 0 0 2 2 2 2 AIR synthase related protein, N-terminal domain FGAR-AT_linker PF18072.1 AIC14837.1 - 3.4e-08 33.9 0.3 1.2e-07 32.1 0.3 2.0 1 0 0 1 1 1 1 Formylglycinamide ribonucleotide amidotransferase linker domain GATase_5 PF13507.6 AIC14838.1 - 2.3e-43 148.2 0.0 3.2e-43 147.7 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase_3 PF07685.14 AIC14838.1 - 1.1e-08 34.9 0.0 2.2e-08 33.9 0.0 1.6 2 0 0 2 2 2 1 CobB/CobQ-like glutamine amidotransferase domain DJ-1_PfpI PF01965.24 AIC14838.1 - 1.7e-08 34.4 0.2 4.8e-08 33.0 0.0 1.8 2 0 0 2 2 2 1 DJ-1/PfpI family GATase PF00117.28 AIC14838.1 - 2.4e-07 30.7 0.0 4.4e-07 29.9 0.0 1.4 1 1 0 1 1 1 1 Glutamine amidotransferase class-I SNO PF01174.19 AIC14838.1 - 0.00094 19.1 0.0 0.0031 17.4 0.0 1.7 1 1 0 1 1 1 1 SNO glutamine amidotransferase family HSP33 PF01430.19 AIC14838.1 - 0.002 17.6 0.0 0.0026 17.2 0.0 1.2 1 0 0 1 1 1 1 Hsp33 protein Peptidase_C26 PF07722.13 AIC14838.1 - 0.0031 17.3 0.0 0.0053 16.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 CBS PF00571.28 AIC14839.1 - 3.4e-30 104.2 6.8 4.1e-16 59.2 0.3 2.8 3 0 0 3 3 3 2 CBS domain MAPKK1_Int PF08923.10 AIC14839.1 - 0.01 15.7 0.1 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting IF3_N PF05198.16 AIC14839.1 - 0.093 13.0 0.1 0.46 10.8 0.0 2.1 1 1 1 2 2 2 0 Translation initiation factor IF-3, N-terminal domain PurS PF02700.14 AIC14840.1 - 1.1e-20 73.6 0.3 1.2e-20 73.4 0.3 1.0 1 0 0 1 1 1 1 Phosphoribosylformylglycinamidine (FGAM) synthase DEP PF00610.21 AIC14840.1 - 0.1 12.6 0.0 4.2 7.5 0.0 2.1 1 1 1 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Nitroreductase PF00881.24 AIC14841.1 - 5.2e-20 72.2 0.0 3.7e-10 40.1 0.0 2.0 1 1 1 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 AIC14841.1 - 1.8e-10 40.8 0.0 8e-05 22.3 0.0 2.0 1 1 1 2 2 2 2 Putative TM nitroreductase Gram_pos_anchor PF00746.21 AIC14843.1 - 0.016 15.1 1.1 0.039 13.9 1.1 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif TIMP PF00965.17 AIC14843.1 - 0.068 13.0 0.0 0.089 12.6 0.0 1.2 1 0 0 1 1 1 0 Tissue inhibitor of metalloproteinase Glycophorin_A PF01102.18 AIC14845.1 - 0.0069 16.6 0.0 0.0092 16.2 0.0 1.4 1 0 0 1 1 1 1 Glycophorin A MitoNEET_N PF10660.9 AIC14845.1 - 0.014 15.4 0.2 0.026 14.6 0.2 1.4 1 0 0 1 1 1 0 Iron-containing outer mitochondrial membrane protein N-terminus Glyco_transf_4 PF13439.6 AIC14846.1 - 0.046 13.7 0.0 0.064 13.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase Family 4 DsbD PF02683.15 AIC14847.1 - 0.045 13.7 0.7 0.07 13.0 0.7 1.2 1 0 0 1 1 1 0 Cytochrome C biogenesis protein transmembrane region Bromo_TP PF07524.13 AIC14847.1 - 0.068 13.2 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 Bromodomain associated DAO_C PF16901.5 AIC14847.1 - 0.11 12.4 0.1 3.3 7.6 0.0 2.4 2 1 0 2 2 2 0 C-terminal domain of alpha-glycerophosphate oxidase TssN PF17555.2 AIC14847.1 - 0.12 11.8 1.3 0.16 11.3 1.3 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN HTH_34 PF13601.6 AIC14848.1 - 0.00015 21.9 0.0 0.00063 19.9 0.0 1.9 2 0 0 2 2 2 1 Winged helix DNA-binding domain DUF4364 PF14277.6 AIC14848.1 - 0.00092 19.0 0.1 0.0011 18.7 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_45 PF14947.6 AIC14848.1 - 0.04 13.9 0.6 0.21 11.6 0.6 2.0 1 1 0 1 1 1 0 Winged helix-turn-helix PadR PF03551.14 AIC14848.1 - 0.047 13.6 0.1 0.061 13.3 0.1 1.4 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family Phage_int_SAM_4 PF13495.6 AIC14848.1 - 0.063 13.8 0.1 0.42 11.1 0.1 2.0 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DUF3116 PF11313.8 AIC14848.1 - 0.094 12.6 0.6 0.16 11.9 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3116) ABC2_membrane PF01061.24 AIC14849.1 - 2.1e-16 60.0 23.0 3e-16 59.5 23.0 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIC14849.1 - 1.2e-09 37.7 24.2 1.9e-09 37.1 23.9 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 AIC14850.1 - 1.9e-27 96.4 0.0 2.8e-27 95.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC14850.1 - 5e-10 39.7 0.0 4e-07 30.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIC14850.1 - 0.0052 16.3 0.0 0.12 11.8 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain TsaE PF02367.17 AIC14850.1 - 0.0062 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 AIC14850.1 - 0.0074 16.0 0.1 0.031 14.0 0.1 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_30 PF13604.6 AIC14850.1 - 0.018 14.8 0.2 0.13 12.0 0.2 2.2 1 1 0 1 1 1 0 AAA domain SbcCD_C PF13558.6 AIC14850.1 - 0.035 14.3 0.0 0.5 10.6 0.0 2.5 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_33 PF13671.6 AIC14850.1 - 0.038 14.2 0.0 0.075 13.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 AIC14850.1 - 0.041 13.5 0.2 0.076 12.6 0.2 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_15 PF13175.6 AIC14850.1 - 0.051 13.3 0.0 3.8 7.1 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 AIC14850.1 - 0.088 13.3 0.0 0.15 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 AIC14850.1 - 0.13 12.7 0.0 0.25 11.8 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 AIC14850.1 - 0.15 12.4 0.1 0.41 10.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain TOBE PF03459.17 AIC14852.1 - 0.18 12.1 0.0 2.9 8.2 0.0 2.1 2 0 0 2 2 2 0 TOBE domain Peptidase_M50 PF02163.22 AIC14853.1 - 2.1e-26 92.7 2.0 3.7e-26 91.9 2.0 1.3 1 0 0 1 1 1 1 Peptidase family M50 PDZ_6 PF17820.1 AIC14853.1 - 5.6e-05 22.9 0.5 9.1e-05 22.2 0.5 1.4 1 0 0 1 1 1 1 PDZ domain Tricorn_PDZ PF14685.6 AIC14853.1 - 0.0089 16.0 0.1 0.017 15.1 0.1 1.4 1 0 0 1 1 1 1 Tricorn protease PDZ domain PDZ_2 PF13180.6 AIC14853.1 - 0.009 16.3 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 AIC14853.1 - 0.086 13.2 0.1 0.27 11.6 0.1 1.8 1 0 0 1 1 1 0 PDZ domain FA_desaturase PF00487.24 AIC14853.1 - 0.25 11.1 4.2 2 8.2 0.1 2.9 3 0 0 3 3 3 0 Fatty acid desaturase Phage_holin_4_1 PF05105.12 AIC14853.1 - 0.52 10.5 4.1 0.68 10.1 0.3 2.7 3 0 0 3 3 3 0 Bacteriophage holin family TIR_2 PF13676.6 AIC14855.1 - 1.2e-06 29.1 0.1 2.4e-06 28.1 0.1 1.5 1 1 1 2 2 2 1 TIR domain TIR-like PF10137.9 AIC14855.1 - 0.00011 22.1 0.1 0.00017 21.6 0.1 1.2 1 0 0 1 1 1 1 Predicted nucleotide-binding protein containing TIR-like domain DUF4062 PF13271.6 AIC14855.1 - 0.0092 16.3 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) DUF1863 PF08937.11 AIC14855.1 - 0.015 15.6 2.5 0.062 13.6 2.6 1.8 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) HypA PF01155.19 AIC14855.1 - 0.19 11.8 1.3 0.38 10.8 1.3 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 AIC14855.1 - 5.6 7.0 9.0 2.5 8.2 1.6 2.3 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Prion_bPrPp PF11587.8 AIC14858.1 - 0.1 12.4 0.2 0.21 11.5 0.2 1.5 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal HTH_45 PF14947.6 AIC14859.1 - 0.0013 18.7 0.0 0.0034 17.3 0.0 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_5 PF01022.20 AIC14859.1 - 0.002 18.0 0.0 0.004 17.0 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family DUF4364 PF14277.6 AIC14859.1 - 0.078 12.7 0.7 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) DDE_Tnp_IS240 PF13610.6 AIC14860.1 - 4.2e-14 52.9 1.5 5.5e-14 52.6 0.2 1.9 2 0 0 2 2 2 1 DDE domain rve_3 PF13683.6 AIC14860.1 - 1.8e-07 30.8 0.0 2e-06 27.5 0.0 2.4 2 0 0 2 2 2 1 Integrase core domain DDE_Tnp_IS66 PF03050.14 AIC14860.1 - 2.9e-07 30.3 0.1 2.4e-06 27.2 0.1 2.1 1 1 0 1 1 1 1 Transposase IS66 family SWIM PF04434.17 AIC14860.1 - 0.0005 19.7 0.9 0.0013 18.3 0.9 1.7 1 0 0 1 1 1 1 SWIM zinc finger Transposase_mut PF00872.18 AIC14860.1 - 0.00093 18.1 0.2 0.0071 15.2 0.1 2.0 2 0 0 2 2 2 1 Transposase, Mutator family Elf1 PF05129.13 AIC14860.1 - 0.0017 18.3 0.8 0.0041 17.1 0.8 1.7 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like rve PF00665.26 AIC14860.1 - 0.004 17.3 0.1 0.0089 16.2 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain Zn_Tnp_IS1 PF03811.13 AIC14860.1 - 0.28 10.9 5.8 0.75 9.6 5.8 1.7 1 0 0 1 1 1 0 InsA N-terminal domain Zn_Tnp_IS1595 PF12760.7 AIC14860.1 - 1.5 8.8 6.4 1.6 8.8 4.8 1.9 2 0 0 2 2 2 0 Transposase zinc-ribbon domain PHD PF00628.29 AIC14860.1 - 8 6.4 8.1 0.37 10.7 1.5 2.2 2 0 0 2 2 2 0 PHD-finger KH_7 PF17214.3 AIC14862.1 - 1.1e-21 76.5 0.3 5.7e-20 71.0 0.1 2.8 2 0 0 2 2 2 1 KH domain Beta-Casp PF10996.8 AIC14862.1 - 6e-21 74.8 0.0 1.2e-20 73.8 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 AIC14862.1 - 4.6e-16 58.8 0.0 8e-16 58.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain RMMBL PF07521.12 AIC14862.1 - 2.5e-15 56.1 0.0 5.3e-15 55.1 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 AIC14862.1 - 1.4e-10 41.6 0.0 1.1e-09 38.6 0.0 2.1 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIC14862.1 - 7.4e-09 35.4 0.0 3e-07 30.2 0.0 2.5 2 0 0 2 2 2 1 Beta-lactamase superfamily domain HARE-HTH PF05066.13 AIC14862.1 - 0.034 14.5 0.0 1.2 9.6 0.0 2.5 2 0 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain Lactamase_B_3 PF13483.6 AIC14862.1 - 0.067 13.1 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 Beta-lactamase superfamily domain DRMBL PF07522.14 AIC14862.1 - 0.15 12.3 0.0 0.4 10.9 0.0 1.7 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase RuvA_C PF07499.13 AIC14865.1 - 0.17 12.4 2.0 0.29 11.6 0.1 2.3 2 0 0 2 2 2 0 RuvA, C-terminal domain HisKA_3 PF07730.13 AIC14865.1 - 0.3 11.6 0.1 0.3 11.6 0.1 4.1 1 1 2 3 3 3 0 Histidine kinase DUF948 PF06103.11 AIC14865.1 - 0.43 10.9 5.3 7.7 6.9 0.8 3.2 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) Amidohydro_2 PF04909.14 AIC14865.1 - 0.64 9.7 4.2 1 9.0 4.2 1.5 1 1 0 1 1 1 0 Amidohydrolase TMP_2 PF06791.13 AIC14865.1 - 1 9.0 15.3 1.5 8.5 7.1 2.5 1 1 2 3 3 3 0 Prophage tail length tape measure protein DUF2203 PF09969.9 AIC14865.1 - 1.2 9.9 7.7 2 9.1 0.5 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) SLY PF12485.8 AIC14865.1 - 3.6 8.3 12.0 3 8.5 1.2 2.1 1 1 1 2 2 2 0 Lymphocyte signaling adaptor protein REF PF05755.12 AIC14865.1 - 4.1 7.2 15.0 31 4.3 5.0 3.5 1 1 2 3 3 3 0 Rubber elongation factor protein (REF) Neur_chan_memb PF02932.16 AIC14865.1 - 5 7.1 7.0 7.4 6.6 5.5 1.7 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region UPF0147 PF03685.13 AIC14866.1 - 5.9e-27 93.5 3.0 7.1e-27 93.3 3.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0147) Ribosomal_S20p PF01649.18 AIC14866.1 - 0.012 16.3 5.3 0.091 13.4 5.1 2.2 1 1 0 1 1 1 0 Ribosomal protein S20 PadR PF03551.14 AIC14867.1 - 0.036 14.0 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_45 PF14947.6 AIC14867.1 - 0.075 13.0 0.0 0.14 12.2 0.0 1.5 1 1 0 1 1 1 0 Winged helix-turn-helix Usp PF00582.26 AIC14869.1 - 3.4e-32 111.9 0.1 4.4e-32 111.5 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family Na_Ca_ex PF01699.24 AIC14870.1 - 1.5e-28 99.6 36.7 3.2e-14 53.1 14.4 2.1 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Spore_YabQ PF09578.10 AIC14870.1 - 0.43 10.8 10.4 0.34 11.1 6.7 2.5 2 0 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) Bax1-I PF01027.20 AIC14870.1 - 8.5 6.1 38.6 0.013 15.3 15.9 2.3 1 1 1 2 2 2 0 Inhibitor of apoptosis-promoting Bax1 Methyltransf_31 PF13847.6 AIC14871.1 - 0.033 14.0 0.2 0.057 13.2 0.2 1.3 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 AIC14871.1 - 0.11 13.2 0.0 0.2 12.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 AIC14871.1 - 0.2 11.3 0.1 0.32 10.6 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Zn_Tnp_IS1595 PF12760.7 AIC14872.1 - 0.002 18.1 1.4 0.0025 17.8 1.4 1.2 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Rubredoxin_2 PF18073.1 AIC14872.1 - 0.033 13.9 1.2 0.044 13.5 1.2 1.2 1 0 0 1 1 1 0 Rubredoxin metal binding domain DNA_RNApol_7kD PF03604.13 AIC14872.1 - 0.042 13.5 5.9 0.097 12.4 5.9 1.7 1 1 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit DUF1451 PF07295.11 AIC14872.1 - 0.1 12.6 0.3 0.12 12.4 0.3 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain Zn-ribbon_8 PF09723.10 AIC14872.1 - 1.8 8.8 5.7 3.7 7.7 5.7 1.7 1 1 0 1 1 1 0 Zinc ribbon domain YtxH PF12732.7 AIC14873.1 - 0.019 15.5 11.1 0.073 13.6 11.1 1.8 1 1 0 1 1 1 0 YtxH-like protein DUF883 PF05957.13 AIC14873.1 - 0.062 13.9 4.1 0.071 13.7 4.1 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF883) ATP-synt_B PF00430.18 AIC14873.1 - 0.11 12.6 11.4 0.12 12.4 11.4 1.1 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) MT0933_antitox PF14013.6 AIC14873.1 - 0.21 11.9 24.3 14 6.1 19.2 2.8 1 1 1 2 2 2 0 MT0933-like antitoxin protein HR1 PF02185.16 AIC14873.1 - 0.37 10.9 3.6 0.46 10.6 3.6 1.3 1 1 0 1 1 1 0 Hr1 repeat Borrelia_P83 PF05262.11 AIC14873.1 - 1.8 7.0 11.6 1.9 6.9 11.6 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein AgrB PF04647.15 AIC14875.1 - 0.034 13.5 0.1 0.038 13.3 0.1 1.1 1 0 0 1 1 1 0 Accessory gene regulator B FeoB_associated PF12669.7 AIC14875.1 - 0.11 13.0 1.3 0.64 10.5 0.0 2.1 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Integrase_Zn PF02022.19 AIC14877.1 - 0.23 11.4 0.0 0.36 10.8 0.0 1.3 1 0 0 1 1 1 0 Integrase Zinc binding domain CoA_binding PF02629.19 AIC14878.1 - 2.1e-21 76.4 0.6 6.3e-21 74.9 0.6 1.8 1 0 0 1 1 1 1 CoA binding domain Ligase_CoA PF00549.19 AIC14878.1 - 5.3e-09 36.1 0.0 9.3e-09 35.3 0.0 1.3 1 0 0 1 1 1 1 CoA-ligase Succ_CoA_lig PF13607.6 AIC14878.1 - 0.00016 21.5 0.0 0.00025 20.9 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AIC14878.1 - 0.00019 21.9 0.0 0.00042 20.8 0.0 1.6 1 0 0 1 1 1 1 CoA binding domain GFO_IDH_MocA PF01408.22 AIC14878.1 - 0.13 13.1 0.0 0.39 11.5 0.0 1.8 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold ATP-grasp_2 PF08442.10 AIC14879.1 - 4.9e-40 137.3 0.1 8.6e-40 136.5 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_5 PF13549.6 AIC14879.1 - 4.5e-14 52.5 0.1 3.3e-13 49.6 0.1 2.1 1 1 0 1 1 1 1 ATP-grasp domain Ligase_CoA PF00549.19 AIC14879.1 - 1.2e-13 51.2 1.0 2.1e-13 50.3 1.0 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp PF02222.22 AIC14879.1 - 4.7e-05 23.0 0.0 8.6e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AIC14879.1 - 0.00027 20.5 0.1 0.00057 19.5 0.0 1.7 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase L chain, ATP binding domain GARS_A PF01071.19 AIC14879.1 - 0.044 13.5 0.0 0.098 12.4 0.0 1.6 1 0 0 1 1 1 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain PHINT_rpt PF14882.6 AIC14879.1 - 0.17 12.2 0.5 0.52 10.6 0.2 2.0 2 0 0 2 2 2 0 Phage-integrase repeat unit Transp_cyt_pur PF02133.15 AIC14880.1 - 1.5e-30 106.4 33.9 2.3e-30 105.8 33.9 1.3 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin ThiC_Rad_SAM PF01964.18 AIC14881.1 - 2.9e-174 579.8 0.1 3.4e-174 579.6 0.1 1.0 1 0 0 1 1 1 1 Radical SAM ThiC family Phos_pyr_kin PF08543.12 AIC14884.1 - 1.1e-82 277.1 2.1 1.5e-82 276.7 2.1 1.2 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase ThiP_synth PF10120.9 AIC14884.1 - 2.3e-58 196.4 1.1 5.1e-57 192.1 0.4 2.5 3 0 0 3 3 3 1 Thiamine-phosphate synthase PfkB PF00294.24 AIC14884.1 - 7e-14 51.8 0.1 1.3e-13 51.0 0.1 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Carb_kinase PF01256.17 AIC14884.1 - 0.043 13.3 0.3 0.11 12.0 0.4 1.6 2 0 0 2 2 2 0 Carbohydrate kinase NTP_transferase PF00483.23 AIC14885.1 - 2.9e-36 125.3 0.0 3.3e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 AIC14885.1 - 1e-11 45.4 0.0 1.4e-11 45.0 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain CTP_transf_3 PF02348.19 AIC14885.1 - 5.1e-05 23.3 0.0 7.7e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Cytidylyltransferase IspD PF01128.19 AIC14885.1 - 0.0013 18.5 0.0 0.0021 17.9 0.0 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NTP_transf_4 PF13562.6 AIC14886.1 - 1.4e-16 61.1 0.0 2.2e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 Sugar nucleotidyl transferase Hexapep PF00132.24 AIC14886.1 - 6.6e-06 25.6 0.7 1.4 8.7 0.0 5.2 4 1 0 5 5 5 2 Bacterial transferase hexapeptide (six repeats) DUF4954 PF16314.5 AIC14886.1 - 0.0038 15.4 1.0 1.1 7.3 0.1 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4954) Phage_integrase PF00589.22 AIC14887.1 - 0.00014 21.7 0.0 0.0011 18.8 0.0 2.3 1 1 0 1 1 1 1 Phage integrase family HTH_38 PF13936.6 AIC14887.1 - 0.00035 20.3 0.3 0.00035 20.3 0.3 2.5 3 1 0 3 3 3 1 Helix-turn-helix domain SCO1-SenC PF02630.14 AIC14888.1 - 0.13 12.2 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 SCO1/SenC HTH_Crp_2 PF13545.6 AIC14889.1 - 2.4e-05 24.2 0.0 4.4e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain FUR PF01475.19 AIC14889.1 - 0.0055 16.9 0.0 0.0069 16.5 0.0 1.3 1 0 0 1 1 1 1 Ferric uptake regulator family LacI PF00356.21 AIC14889.1 - 0.0096 15.7 0.1 0.029 14.2 0.1 1.8 1 0 0 1 1 1 1 Bacterial regulatory proteins, lacI family HTH_23 PF13384.6 AIC14889.1 - 0.011 15.4 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain HTH_24 PF13412.6 AIC14889.1 - 0.061 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Ubiq_cyt_C_chap PF03981.12 AIC14889.1 - 0.076 13.1 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone McrBC PF10117.9 AIC14891.1 - 0.00029 20.1 0.0 0.00065 18.9 0.0 1.7 1 1 0 1 1 1 1 McrBC 5-methylcytosine restriction system component PDDEXK_7 PF04411.12 AIC14891.1 - 0.034 14.1 0.3 1 9.3 0.3 2.3 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily AAA_5 PF07728.14 AIC14892.1 - 3.4e-16 59.5 0.0 6.6e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 AIC14892.1 - 0.0014 19.1 0.1 0.011 16.2 0.0 2.4 3 0 0 3 3 3 1 AAA ATPase domain AAA_30 PF13604.6 AIC14892.1 - 0.0015 18.3 0.0 0.0026 17.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AIC14892.1 - 0.0068 15.8 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 AIC14892.1 - 0.019 15.3 0.0 0.084 13.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 AIC14892.1 - 0.03 14.6 0.0 0.16 12.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 AIC14892.1 - 0.056 13.5 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 AIC14892.1 - 0.084 13.4 0.0 0.41 11.2 0.0 2.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AIC14892.1 - 0.092 12.2 0.0 0.25 10.8 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region RuvB_N PF05496.12 AIC14892.1 - 0.11 12.3 0.2 0.3 10.8 0.0 1.8 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 AIC14892.1 - 0.11 12.9 0.1 0.7 10.3 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 AIC14892.1 - 0.16 11.2 0.0 0.29 10.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain DUF4897 PF16238.5 AIC14892.1 - 0.27 11.1 2.2 37 4.1 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4897) DUF2115 PF09888.9 AIC14892.1 - 7.1 7.1 9.1 16 5.9 0.2 4.1 3 1 1 4 4 4 0 Uncharacterized protein conserved in archaea (DUF2115) SIMPL PF04402.14 AIC14893.1 - 6.8e-31 108.3 7.2 7.1e-18 65.8 0.5 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF541) DUF4140 PF13600.6 AIC14893.1 - 0.063 13.7 1.9 0.17 12.3 0.1 2.4 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) FtsX_ECD PF18075.1 AIC14893.1 - 0.093 13.4 1.0 0.34 11.5 0.2 2.3 3 0 0 3 3 3 0 FtsX extracellular domain DUF3801 PF12687.7 AIC14893.1 - 0.14 12.2 0.8 1 9.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3801) Epimerase_2 PF02350.19 AIC14895.1 - 4.1e-30 104.8 0.0 1.4e-26 93.2 0.0 2.1 2 0 0 2 2 2 2 UDP-N-acetylglucosamine 2-epimerase 7TMR-DISM_7TM PF07695.11 AIC14896.1 - 0.39 10.6 10.1 1.2 9.0 10.0 1.8 1 1 0 1 1 1 0 7TM diverse intracellular signalling GalP_UDP_transf PF01087.22 AIC14897.1 - 4.1e-11 43.6 0.1 1e-09 39.1 0.0 2.2 2 0 0 2 2 2 1 Galactose-1-phosphate uridyl transferase, N-terminal domain DUF4921 PF16268.5 AIC14897.1 - 1.9e-09 36.9 0.1 1.3e-08 34.1 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4921) HIT PF01230.23 AIC14897.1 - 4.6e-09 36.9 0.0 0.0014 19.3 0.0 2.5 3 0 0 3 3 3 2 HIT domain GalP_UDP_tr_C PF02744.17 AIC14897.1 - 4.1e-05 23.4 0.0 7.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Galactose-1-phosphate uridyl transferase, C-terminal domain DUF4931 PF16285.5 AIC14897.1 - 0.0041 16.5 0.7 0.0075 15.6 0.1 1.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4931) DcpS_C PF11969.8 AIC14897.1 - 0.0096 16.4 0.0 0.026 15.0 0.0 1.7 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding DUF3797 PF12677.7 AIC14897.1 - 0.047 13.6 0.1 4.9 7.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3797) zf-FPG_IleRS PF06827.14 AIC14898.1 - 0.00022 21.0 1.2 0.00057 19.7 0.2 1.9 2 0 0 2 2 2 1 Zinc finger found in FPG and IleRS TF_Zn_Ribbon PF08271.12 AIC14898.1 - 0.00069 19.1 2.0 0.017 14.6 1.9 2.1 1 1 0 1 1 1 1 TFIIB zinc-binding zf_UBZ PF18439.1 AIC14898.1 - 0.0082 15.7 0.2 0.21 11.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger Gin PF10764.9 AIC14898.1 - 0.033 14.1 0.3 0.11 12.5 0.3 1.7 1 1 0 1 1 1 0 Inhibitor of sigma-G Gin Zn_Tnp_IS1595 PF12760.7 AIC14898.1 - 0.039 13.9 0.3 0.053 13.5 0.3 1.2 1 0 0 1 1 1 0 Transposase zinc-ribbon domain zf-BED PF02892.15 AIC14898.1 - 0.081 13.0 0.3 1.7 8.8 0.0 2.0 2 0 0 2 2 2 0 BED zinc finger zf-C4_ClpX PF06689.13 AIC14898.1 - 0.12 12.3 3.3 2.5 8.1 3.3 2.0 1 1 0 1 1 1 0 ClpX C4-type zinc finger zf-CCHC_2 PF13696.6 AIC14898.1 - 0.38 10.6 3.8 2 8.3 0.2 2.1 2 0 0 2 2 2 0 Zinc knuckle PhosphMutase PF10143.9 AIC14900.1 - 3.3e-44 150.8 0.1 4.7e-44 150.3 0.1 1.2 1 0 0 1 1 1 1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase Metalloenzyme PF01676.18 AIC14900.1 - 1.5e-23 83.4 0.1 1.9e-23 83.1 0.1 1.0 1 0 0 1 1 1 1 Metalloenzyme superfamily Gram_pos_anchor PF00746.21 AIC14901.1 - 0.00027 20.8 1.1 0.0016 18.3 0.0 2.0 2 0 0 2 2 2 1 LPXTG cell wall anchor motif DUF2142 PF09913.9 AIC14901.1 - 0.02 13.7 0.6 0.023 13.6 0.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) PMP22_Claudin PF00822.20 AIC14901.1 - 0.043 13.7 0.0 0.046 13.6 0.0 1.0 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family DUF4131 PF13567.6 AIC14901.1 - 0.047 13.3 0.0 0.048 13.3 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) FeoB_associated PF12669.7 AIC14901.1 - 0.051 14.0 0.2 2 8.9 0.0 2.0 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein DUF202 PF02656.15 AIC14901.1 - 0.3 11.6 2.2 0.42 11.1 2.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF202) PsbX PF06596.11 AIC14901.1 - 2.5 8.2 6.6 4.2 7.5 2.3 2.1 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) DZR PF12773.7 AIC14902.1 - 0.0031 17.5 1.1 0.0042 17.1 1.1 1.2 1 0 0 1 1 1 1 Double zinc ribbon DUF4379 PF14311.6 AIC14902.1 - 0.0082 16.5 0.7 0.012 16.0 0.7 1.3 1 0 0 1 1 1 1 Probable Zinc-ribbon domain NOB1_Zn_bind PF08772.11 AIC14902.1 - 0.03 14.5 0.1 0.035 14.3 0.1 1.1 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 AIC14902.1 - 0.092 12.5 3.6 2.8 7.8 0.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain DUF2321 PF10083.9 AIC14902.1 - 0.11 12.1 0.3 0.12 12.0 0.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2321) RNA_POL_M_15KD PF02150.16 AIC14902.1 - 5.5 7.0 8.3 87 3.1 8.3 2.1 1 1 0 1 1 1 0 RNA polymerases M/15 Kd subunit TFIIB PF00382.19 AIC14903.1 - 8.1e-26 89.9 4.2 9e-13 48.1 1.6 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIC14903.1 - 9.9e-09 34.6 0.7 9.9e-09 34.6 0.7 1.9 2 0 0 2 2 2 1 TFIIB zinc-binding zf-C4_Topoisom PF01396.19 AIC14903.1 - 0.061 13.1 1.7 0.53 10.1 0.7 2.5 2 1 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Cyclin_N PF00134.23 AIC14903.1 - 0.063 13.0 5.5 0.26 11.0 4.5 2.3 1 1 1 2 2 2 0 Cyclin, N-terminal domain OrfB_Zn_ribbon PF07282.11 AIC14903.1 - 0.19 11.7 5.3 0.05 13.5 1.8 1.8 2 0 0 2 2 2 0 Putative transposase DNA-binding domain Auto_anti-p27 PF06677.12 AIC14903.1 - 4.2 7.6 6.1 1.4 9.1 2.3 2.2 2 0 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Spt4 PF06093.13 AIC14903.1 - 4.5 7.4 6.5 16 5.7 0.6 2.7 2 1 0 2 2 2 0 Spt4/RpoE2 zinc finger Gar1 PF04410.14 AIC14904.1 - 3.2e-08 33.5 0.0 3.5e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Gar1/Naf1 RNA binding region GTP_EFTU_D4 PF14578.6 AIC14904.1 - 0.014 15.3 0.4 0.21 11.5 0.1 2.1 1 1 1 2 2 2 0 Elongation factor Tu domain 4 SRP19 PF01922.17 AIC14905.1 - 8.9e-15 55.4 0.2 1.1e-14 55.1 0.2 1.1 1 0 0 1 1 1 1 SRP19 protein Ribosomal_S8e PF01201.22 AIC14906.1 - 1.2e-27 96.7 4.0 1.3e-27 96.6 4.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S8e SMC_ScpB PF04079.16 AIC14907.1 - 2.5e-36 124.7 0.8 3e-36 124.4 0.8 1.1 1 0 0 1 1 1 1 Segregation and condensation complex subunit ScpB HTH_20 PF12840.7 AIC14907.1 - 0.0031 17.6 0.1 0.25 11.4 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.19 AIC14907.1 - 0.009 15.9 1.3 0.17 11.8 0.2 2.6 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 AIC14907.1 - 0.044 13.7 0.3 0.29 11.1 0.1 2.2 2 0 0 2 2 2 0 Transcriptional regulator PadR-like family HTH_15 PF12324.8 AIC14907.1 - 0.051 13.5 0.1 6.1 6.9 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase PGM_PMM_IV PF00408.20 AIC14907.1 - 0.095 12.9 0.4 0.77 10.0 0.2 2.3 1 1 1 2 2 2 0 Phosphoglucomutase/phosphomannomutase, C-terminal domain DprA_WH PF17782.1 AIC14907.1 - 0.1 12.8 0.1 0.21 11.7 0.1 1.6 1 0 0 1 1 1 0 DprA winged helix domain SMC_ScpA PF02616.14 AIC14908.1 - 2.7e-10 40.6 0.7 0.00011 22.2 0.1 2.1 2 0 0 2 2 2 2 Segregation and condensation protein ScpA CNDH2_C PF16858.5 AIC14908.1 - 1.4e-06 28.4 0.0 2.1e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term SNase PF00565.17 AIC14909.1 - 1.6e-07 31.7 0.0 1.8e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 Staphylococcal nuclease homologue TPR_3 PF07720.12 AIC14910.1 - 0.0091 16.0 0.7 0.13 12.2 0.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 AIC14910.1 - 0.015 15.3 1.1 2.3 8.3 0.1 3.0 1 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain HypD PF01924.16 AIC14910.1 - 0.02 14.0 0.1 0.027 13.6 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase formation hypA family Putative_PNPOx PF01243.20 AIC14912.1 - 6.3e-13 48.7 0.0 8.5e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIC14912.1 - 0.0015 18.2 0.0 0.0018 17.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like DUF5061 PF16587.5 AIC14912.1 - 0.066 13.3 0.0 4.5 7.4 0.0 2.1 2 0 0 2 2 2 0 17 kDa common-antigen outer membrane protein Methyltransf_31 PF13847.6 AIC14913.1 - 5.2e-21 75.0 0.0 8.2e-21 74.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC14913.1 - 5.3e-14 52.7 0.0 9.7e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14913.1 - 1e-12 48.5 0.0 1.9e-12 47.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC14913.1 - 3.1e-12 46.6 0.0 4.9e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC14913.1 - 1.4e-10 41.8 0.0 2.4e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIC14913.1 - 7.2e-09 35.4 0.0 1.3e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 AIC14913.1 - 5.8e-08 32.4 0.0 1.1e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_2 PF00891.18 AIC14913.1 - 9e-06 25.1 0.0 1.3e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_18 PF12847.7 AIC14913.1 - 1.5e-05 24.9 0.0 3.1e-05 24.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC14913.1 - 1.8e-05 24.2 0.0 3.1e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family GCD14 PF08704.10 AIC14913.1 - 6.2e-05 22.8 0.0 9.7e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit PrmA PF06325.13 AIC14913.1 - 0.0004 19.9 0.0 0.00092 18.7 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 AIC14913.1 - 0.00074 18.9 0.0 0.0011 18.3 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase TehB PF03848.14 AIC14913.1 - 0.00094 18.6 0.0 0.002 17.6 0.0 1.5 2 0 0 2 2 2 1 Tellurite resistance protein TehB PCMT PF01135.19 AIC14913.1 - 0.0014 18.5 0.0 0.002 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_32 PF13679.6 AIC14913.1 - 0.027 14.4 0.0 0.044 13.8 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain GidB PF02527.15 AIC14913.1 - 0.14 11.5 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Dimerisation PF08100.11 AIC14913.1 - 0.14 12.2 0.0 0.38 10.8 0.0 1.7 1 0 0 1 1 1 0 Dimerisation domain Dimerisation2 PF16864.5 AIC14913.1 - 0.2 11.6 0.0 0.4 10.7 0.0 1.5 1 0 0 1 1 1 0 Dimerisation domain Oxidored_q6 PF01058.22 AIC14914.1 - 1.5e-30 105.7 1.2 2.8e-30 104.8 0.3 1.8 2 0 0 2 2 2 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Fer4_7 PF12838.7 AIC14914.1 - 0.0007 20.1 0.4 0.0053 17.3 0.2 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_13 PF13370.6 AIC14914.1 - 0.02 15.4 0.1 0.02 15.4 0.1 2.4 3 0 0 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_8 PF13183.6 AIC14914.1 - 0.023 15.1 0.1 0.045 14.2 0.1 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIC14914.1 - 0.027 14.6 0.8 0.11 12.7 0.8 2.0 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4 PF00037.27 AIC14914.1 - 0.028 14.2 5.5 0.078 12.8 0.6 2.5 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_2 PF12797.7 AIC14914.1 - 0.17 12.0 3.0 6.5 7.1 0.2 2.8 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_15 PF13459.6 AIC14914.1 - 0.2 12.4 2.7 0.2 12.4 0.1 2.4 3 0 0 3 3 3 0 4Fe-4S single cluster domain Complex1_49kDa PF00346.19 AIC14915.1 - 3.4e-35 121.4 0.2 9.2e-31 106.9 0.3 2.3 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Complex1_30kDa PF00329.19 AIC14915.1 - 1.8e-19 70.6 0.0 3.8e-19 69.5 0.0 1.5 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Proton_antipo_M PF00361.20 AIC14916.1 - 1.9e-58 198.0 24.9 1.9e-58 198.0 24.9 1.7 2 0 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIC14916.1 - 3.4e-05 23.8 0.1 3.4e-05 23.8 0.1 3.2 3 0 0 3 3 3 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidored_q2 PF00420.24 AIC14917.1 - 0.0053 16.4 9.4 0.0053 16.4 9.4 3.0 2 2 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L NADHdh PF00146.21 AIC14918.1 - 1e-45 156.4 20.9 1.2e-45 156.1 20.9 1.0 1 0 0 1 1 1 1 NADH dehydrogenase DUF4730 PF15873.5 AIC14918.1 - 0.0079 16.4 2.1 0.061 13.6 2.1 2.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4730) Proton_antipo_M PF00361.20 AIC14919.1 - 3.5e-58 197.1 20.5 3.5e-58 197.1 20.5 2.2 2 1 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIC14919.1 - 8.7e-06 25.7 0.8 5.2e-05 23.2 0.0 2.8 2 0 0 2 2 2 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus TrmB PF01978.19 AIC14920.1 - 0.0055 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB RNA_pol_Rpc34 PF05158.12 AIC14920.1 - 0.0085 15.5 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpc34 subunit HisG_C PF08029.11 AIC14920.1 - 0.046 13.9 0.0 0.1 12.8 0.0 1.6 1 0 0 1 1 1 0 HisG, C-terminal domain OSTMP1 PF09777.9 AIC14920.1 - 0.071 12.5 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Pyridox_ox_2 PF12900.7 AIC14922.1 - 4.6e-11 42.9 0.0 5.5e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 AIC14922.1 - 7.8e-11 42.0 0.0 1.5e-10 41.1 0.0 1.4 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIC14922.1 - 0.022 14.4 0.0 0.027 14.0 0.0 1.2 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like F420H2_quin_red PF04075.14 AIC14922.1 - 0.056 13.6 0.0 0.073 13.2 0.0 1.3 1 0 0 1 1 1 0 F420H(2)-dependent quinone reductase ABC2_membrane PF01061.24 AIC14923.1 - 2.7e-32 111.9 17.8 2.7e-32 111.9 17.8 1.4 1 1 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIC14923.1 - 1.7e-16 60.3 15.0 1.7e-16 60.3 15.0 1.9 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 AIC14923.1 - 6.3 6.0 19.7 0.47 9.7 9.4 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein ABC_tran PF00005.27 AIC14924.1 - 4.4e-26 92.0 0.0 1.2e-25 90.6 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 AIC14924.1 - 2e-14 54.1 1.5 5.5e-09 36.3 0.0 2.2 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 AIC14924.1 - 1.4e-09 38.5 0.0 3.4e-09 37.3 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_29 PF13555.6 AIC14924.1 - 0.00069 19.3 0.2 0.0015 18.2 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Rad17 PF03215.15 AIC14924.1 - 0.0028 17.6 0.0 0.0043 17.0 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 AIC14924.1 - 0.0062 16.8 0.1 0.061 13.6 0.1 2.3 1 1 0 1 1 1 1 AAA domain SRP54 PF00448.22 AIC14924.1 - 0.0067 16.1 0.1 0.011 15.3 0.1 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_23 PF13476.6 AIC14924.1 - 0.0087 16.6 0.0 0.015 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AIC14924.1 - 0.01 16.3 0.0 0.065 13.7 0.0 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MukB PF04310.12 AIC14924.1 - 0.013 15.3 0.1 0.022 14.5 0.1 1.4 1 0 0 1 1 1 0 MukB N-terminal AAA_16 PF13191.6 AIC14924.1 - 0.018 15.4 0.2 0.049 14.0 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain KdpD PF02702.17 AIC14924.1 - 0.042 13.3 0.0 0.078 12.4 0.0 1.4 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain AAA_30 PF13604.6 AIC14924.1 - 0.063 13.0 1.7 0.08 12.6 0.3 1.9 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AIC14924.1 - 0.079 12.7 0.0 0.19 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 AIC14924.1 - 0.096 12.1 0.0 8.2 5.8 0.0 2.2 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AIC14924.1 - 0.15 11.7 0.0 1.4 8.5 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Abhydrolase_6 PF12697.7 AIC14925.1 - 9.7e-11 42.7 0.0 1.2e-10 42.4 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 AIC14925.1 - 7.5e-10 38.9 0.0 1.8e-06 27.8 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 AIC14925.1 - 0.0013 18.0 0.0 0.0032 16.8 0.0 1.6 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Esterase PF00756.20 AIC14925.1 - 0.0051 16.5 0.0 0.0076 15.9 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Ndr PF03096.14 AIC14925.1 - 0.025 13.3 0.0 0.046 12.4 0.0 1.4 1 0 0 1 1 1 0 Ndr family Thioesterase PF00975.20 AIC14925.1 - 0.13 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Thioesterase domain Methyltransf_21 PF05050.12 AIC14926.1 - 2.4e-23 83.0 0.0 3.2e-23 82.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase FkbM domain Met_10 PF02475.16 AIC14926.1 - 1.4e-07 31.5 0.0 2.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_23 PF13489.6 AIC14926.1 - 0.00011 22.0 0.0 0.00032 20.6 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain V_cholerae_RfbT PF05575.11 AIC14926.1 - 0.00046 19.6 0.0 0.00086 18.7 0.0 1.4 1 0 0 1 1 1 1 Vibrio cholerae RfbT protein tRNA_U5-meth_tr PF05958.11 AIC14926.1 - 0.003 16.6 0.0 0.0041 16.2 0.0 1.1 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_25 PF13649.6 AIC14926.1 - 0.0032 18.1 0.0 0.01 16.5 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14926.1 - 0.0069 17.0 0.0 0.025 15.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 AIC14926.1 - 0.0098 15.5 0.0 0.016 14.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_18 PF12847.7 AIC14926.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 AIC14926.1 - 0.016 14.2 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_31 PF13847.6 AIC14926.1 - 0.026 14.3 0.0 0.12 12.1 0.0 2.0 1 1 0 1 1 1 0 Methyltransferase domain N-glycanase_C PF09113.10 AIC14926.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Peptide-N-glycosidase F, C terminal FtsJ PF01728.19 AIC14926.1 - 0.15 12.2 0.0 0.27 11.3 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase HTH_24 PF13412.6 AIC14928.1 - 1.4e-05 24.5 4.5 1.4e-05 24.5 1.1 2.5 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC14928.1 - 7.7e-05 22.4 1.2 7.7e-05 22.4 1.2 2.5 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HTH_IclR PF09339.10 AIC14928.1 - 0.16 11.8 2.9 0.53 10.1 0.6 2.8 3 0 0 3 3 3 0 IclR helix-turn-helix domain TrmB PF01978.19 AIC14928.1 - 0.17 11.8 0.1 0.89 9.5 0.1 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 AIC14928.1 - 0.18 11.7 3.8 1 9.3 0.3 3.1 3 0 0 3 3 3 0 MarR family Pyrid_ox_like PF16242.5 AIC14930.1 - 0.031 13.9 0.0 0.034 13.7 0.0 1.0 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like Imm26 PF15428.6 AIC14930.1 - 0.098 12.9 0.0 0.098 12.9 0.0 1.0 1 0 0 1 1 1 0 Immunity protein 26 CopG_antitoxin PF12441.8 AIC14932.1 - 0.00066 20.2 0.0 0.0016 19.0 0.0 1.7 1 0 0 1 1 1 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIC14932.1 - 0.019 14.8 0.1 0.043 13.7 0.1 1.6 1 0 0 1 1 1 0 HicB family Arc PF03869.14 AIC14932.1 - 0.051 13.4 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Arc-like DNA binding domain SBP_bac_3 PF00497.20 AIC14933.1 - 4e-58 196.5 0.4 4.6e-58 196.3 0.4 1.0 1 0 0 1 1 1 1 Bacterial extracellular solute-binding proteins, family 3 Lig_chan-Glu_bd PF10613.9 AIC14933.1 - 2.7e-09 37.2 0.0 4.8e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Ligated ion channel L-glutamate- and glycine-binding site LysR_substrate PF03466.20 AIC14933.1 - 0.078 12.3 0.0 2.9 7.2 0.0 2.9 1 1 0 2 2 2 0 LysR substrate binding domain CD20 PF04103.15 AIC14934.1 - 0.074 13.1 0.0 0.17 12.0 0.0 1.6 1 1 1 2 2 2 0 CD20-like family TRAP_alpha PF03896.16 AIC14934.1 - 1.6 7.9 6.1 0.25 10.5 2.0 1.6 1 1 1 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Herpes_LMP1 PF05297.11 AIC14934.1 - 8.7 5.4 17.9 12 4.9 17.9 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) bPH_3 PF14470.6 AIC14939.1 - 0.0059 16.9 0.0 0.0074 16.6 0.0 1.1 1 0 0 1 1 1 1 Bacterial PH domain bPH_1 PF08000.11 AIC14939.1 - 0.02 15.0 0.1 0.023 14.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial PH domain TIG PF01833.24 AIC14940.1 - 7.3e-09 35.6 12.1 0.00063 19.8 0.5 4.4 3 3 0 3 3 3 3 IPT/TIG domain MG2 PF01835.19 AIC14940.1 - 4e-06 27.2 5.3 0.11 13.0 0.1 3.8 3 1 1 4 4 4 2 MG2 domain BiPBP_C PF06832.12 AIC14940.1 - 0.0024 17.9 0.2 5.7 7.1 0.0 3.5 2 1 0 2 2 2 2 Penicillin-Binding Protein C-terminus Family DUF4625 PF15418.6 AIC14940.1 - 0.018 15.3 0.1 0.4 10.9 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4625) T2SSI PF02501.17 AIC14940.1 - 0.047 13.8 0.2 0.12 12.5 0.2 1.8 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein I Cupredoxin_1 PF13473.6 AIC14941.1 - 3.9e-06 26.9 0.0 1.1e-05 25.4 0.0 1.8 2 0 0 2 2 2 1 Cupredoxin-like domain MarR_2 PF12802.7 AIC14941.1 - 0.00023 21.0 0.2 0.001 18.9 0.1 2.1 2 0 0 2 2 2 1 MarR family HTH_IclR PF09339.10 AIC14941.1 - 0.0035 17.1 0.0 0.0097 15.7 0.0 1.7 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_24 PF13412.6 AIC14941.1 - 0.044 13.4 0.0 0.08 12.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding CBM60 PF16841.5 AIC14941.1 - 0.083 13.3 0.0 0.25 11.8 0.0 1.7 1 0 0 1 1 1 0 Ca-dependent carbohydrate-binding module xylan-binding DUF905 PF06006.12 AIC14941.1 - 0.13 12.2 0.0 0.36 10.8 0.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF905) SNAP PF14938.6 AIC14941.1 - 0.44 9.9 5.6 0.65 9.4 5.6 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP NnrS PF05940.12 AIC14946.1 - 0.011 15.2 49.3 0.027 13.9 49.3 1.6 1 1 0 1 1 1 0 NnrS protein DUF5594 PF18057.1 AIC14946.1 - 0.048 13.5 0.0 0.096 12.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5594) Kelch_1 PF01344.25 AIC14946.1 - 0.05 13.2 0.0 0.11 12.1 0.0 1.5 1 0 0 1 1 1 0 Kelch motif DUF4191 PF13829.6 AIC14946.1 - 0.4 10.0 7.8 0.58 9.5 0.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) COX1 PF00115.20 AIC14946.1 - 3.8 6.3 40.8 0.08 11.8 21.5 3.2 1 1 2 3 3 3 0 Cytochrome C and Quinol oxidase polypeptide I zf-C2H2_6 PF13912.6 AIC14947.1 - 0.0004 20.3 1.8 0.014 15.4 0.8 2.3 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC14947.1 - 0.01 16.2 0.7 0.019 15.4 0.7 1.5 1 0 0 1 1 1 0 Zinc finger, C2H2 type zf-RanBP PF00641.18 AIC14947.1 - 0.017 14.4 0.8 0.032 13.5 0.8 1.4 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DUF629 PF04780.12 AIC14947.1 - 0.019 13.6 0.6 0.019 13.6 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) zf-C2H2_4 PF13894.6 AIC14947.1 - 0.022 15.6 1.9 0.034 15.0 1.0 1.8 2 0 0 2 2 2 0 C2H2-type zinc finger Abhydrolase_1 PF00561.20 AIC14948.1 - 7e-05 22.6 0.1 8.9e-05 22.3 0.1 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 AIC14948.1 - 0.00038 20.5 0.1 0.00045 20.3 0.1 1.1 1 0 0 1 1 1 1 TAP-like protein FSH1 PF03959.13 AIC14948.1 - 0.0036 17.0 0.4 0.0041 16.8 0.4 1.2 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 AIC14948.1 - 0.0058 15.9 0.2 0.0061 15.9 0.2 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Bmp PF02608.14 AIC14949.1 - 3.7e-60 203.4 1.7 4.6e-60 203.1 1.7 1.1 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like Peripla_BP_4 PF13407.6 AIC14949.1 - 0.00027 20.6 3.7 0.00073 19.2 3.7 1.8 1 1 0 1 1 1 1 Periplasmic binding protein domain AzlD PF05437.12 AIC14949.1 - 0.052 13.7 0.0 0.11 12.7 0.0 1.7 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) Methyltransf_31 PF13847.6 AIC14949.1 - 0.065 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain T2SSM PF04612.12 AIC14949.1 - 0.065 13.3 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M HATPase_c PF02518.26 AIC14950.1 - 3.3e-26 92.0 0.1 7.7e-26 90.8 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIC14950.1 - 7.2e-14 52.2 8.1 3.8e-13 49.8 6.0 3.0 2 1 1 3 3 3 1 Cache domain HisKA PF00512.25 AIC14950.1 - 1.5e-11 44.2 0.7 6.1e-11 42.2 0.4 2.1 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain HATPase_c_3 PF13589.6 AIC14950.1 - 4.9e-05 23.2 0.1 0.00014 21.7 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_5 PF14501.6 AIC14950.1 - 0.00029 20.7 0.4 0.00086 19.2 0.0 1.9 2 0 0 2 2 2 1 GHKL domain HATPase_c_2 PF13581.6 AIC14950.1 - 0.00082 19.3 0.0 0.0018 18.2 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Response_reg PF00072.24 AIC14952.1 - 9.2e-24 83.8 0.2 1.1e-23 83.6 0.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain NDUFV3 PF15880.5 AIC14952.1 - 0.095 12.7 0.0 14 5.8 0.0 2.4 2 0 0 2 2 2 0 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NT5C PF06941.12 AIC14955.1 - 1.3e-18 67.5 0.3 1.5e-18 67.4 0.3 1.0 1 0 0 1 1 1 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) DUF4156 PF13698.6 AIC14957.1 - 0.06 13.7 0.0 0.85 10.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4156) GATase_7 PF13537.6 AIC14957.1 - 0.11 12.4 0.0 0.4 10.6 0.0 2.0 2 0 0 2 2 2 0 Glutamine amidotransferase domain Aconitase_C PF00694.19 AIC14958.1 - 2.4e-36 124.9 0.0 3.5e-36 124.4 0.0 1.2 1 0 0 1 1 1 1 Aconitase C-terminal domain Aconitase_2_N PF06434.13 AIC14958.1 - 0.0013 18.4 0.0 0.066 12.8 0.0 2.1 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus Imm12 PF15560.6 AIC14958.1 - 0.078 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 12 Aconitase PF00330.20 AIC14959.1 - 5.5e-156 520.2 0.0 6.2e-156 520.0 0.0 1.0 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF521 PF04412.13 AIC14959.1 - 0.004 15.9 0.0 0.019 13.7 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF521) Proteasome PF00227.26 AIC14960.1 - 6.3e-53 179.1 1.2 7.4e-53 178.9 1.2 1.0 1 0 0 1 1 1 1 Proteasome subunit Peptidase_M32 PF02074.15 AIC14961.1 - 9.8e-07 27.9 0.0 0.00019 20.4 0.0 2.3 1 1 1 2 2 2 2 Carboxypeptidase Taq (M32) metallopeptidase Peptidase_M3 PF01432.20 AIC14961.1 - 5.8e-05 22.5 2.0 0.0012 18.2 2.0 2.7 1 1 0 1 1 1 1 Peptidase family M3 MCM_N PF14551.6 AIC14961.1 - 0.025 15.2 0.1 0.09 13.4 0.1 1.9 2 0 0 2 2 2 0 MCM N-terminal domain zf-FCS PF06467.14 AIC14963.1 - 0.074 13.0 0.3 0.18 11.7 0.3 1.7 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif Phage_TAC_5 PF08890.11 AIC14964.1 - 0.0045 17.0 3.1 0.0053 16.8 3.1 1.0 1 0 0 1 1 1 1 Phage XkdN-like tail assembly chaperone protein, TAC DUF3300 PF11737.8 AIC14964.1 - 0.09 12.3 0.6 0.097 12.2 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3300) EMC3_TMCO1 PF01956.16 AIC14964.1 - 0.45 10.2 1.8 0.56 9.9 1.4 1.3 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like HTH_45 PF14947.6 AIC14966.1 - 0.0022 18.0 0.0 0.012 15.6 0.0 2.0 2 0 0 2 2 2 1 Winged helix-turn-helix TrmB PF01978.19 AIC14966.1 - 0.0042 16.9 0.0 0.0078 16.1 0.0 1.5 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 AIC14966.1 - 0.0093 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC14966.1 - 0.012 15.7 0.0 0.026 14.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain MarR_2 PF12802.7 AIC14966.1 - 0.033 14.1 0.0 0.071 13.0 0.0 1.5 1 0 0 1 1 1 0 MarR family Radical_SAM PF04055.21 AIC14967.1 - 1e-17 65.0 0.1 1e-17 65.0 0.1 2.6 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 AIC14967.1 - 1.4e-07 31.9 0.0 3.5e-07 30.6 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIC14967.1 - 2.2e-07 31.0 0.0 2.2e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain TrmB PF01978.19 AIC14968.1 - 3.3e-20 71.7 0.0 1e-19 70.2 0.0 1.9 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 AIC14968.1 - 1.9e-09 37.0 0.0 2.7e-09 36.6 0.0 1.1 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_IclR PF09339.10 AIC14968.1 - 2.4e-05 24.1 0.0 8.9e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 IclR helix-turn-helix domain MarR PF01047.22 AIC14968.1 - 0.00078 19.3 0.0 0.0032 17.4 0.0 2.0 2 0 0 2 2 2 1 MarR family HTH_27 PF13463.6 AIC14968.1 - 0.0061 17.0 0.0 0.031 14.8 0.0 2.2 3 0 0 3 3 3 1 Winged helix DNA-binding domain HTH_24 PF13412.6 AIC14968.1 - 0.02 14.4 0.0 0.045 13.3 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Penicillinase_R PF03965.16 AIC14968.1 - 0.023 15.0 0.0 0.072 13.5 0.0 1.9 2 0 0 2 2 2 0 Penicillinase repressor HTH_9 PF08221.11 AIC14968.1 - 0.033 14.3 0.0 0.084 13.0 0.0 1.7 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain PadR PF03551.14 AIC14968.1 - 0.043 13.8 0.0 0.1 12.6 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_36 PF13730.6 AIC14968.1 - 0.078 12.9 0.0 0.16 11.9 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain Rrf2 PF02082.20 AIC14968.1 - 0.12 12.8 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator MarR_2 PF12802.7 AIC14968.1 - 0.15 12.0 0.0 0.53 10.2 0.0 1.9 3 0 0 3 3 3 0 MarR family AbiEi_4 PF13338.6 AIC14968.1 - 0.16 12.1 0.0 0.48 10.6 0.0 1.8 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin Fe_dep_repr_C PF02742.15 AIC14969.1 - 3.1e-19 68.8 0.5 5e-19 68.1 0.5 1.4 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain Fe_dep_repress PF01325.19 AIC14969.1 - 2.7e-14 53.1 0.5 4.9e-14 52.3 0.5 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_5 PF01022.20 AIC14969.1 - 1.9e-05 24.4 0.0 4.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Rrf2 PF02082.20 AIC14969.1 - 0.00018 21.8 0.1 0.0003 21.1 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator MarR_2 PF12802.7 AIC14969.1 - 0.00021 21.1 0.0 0.00035 20.4 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_1 PF00126.27 AIC14969.1 - 0.00058 19.8 0.0 0.0012 18.7 0.0 1.6 1 1 0 1 1 1 1 Bacterial regulatory helix-turn-helix protein, lysR family MarR PF01047.22 AIC14969.1 - 0.00059 19.7 0.0 0.001 18.9 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 AIC14969.1 - 0.002 18.0 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TrmB PF01978.19 AIC14969.1 - 0.0028 17.5 0.1 0.0045 16.8 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_37 PF13744.6 AIC14969.1 - 0.0035 17.3 0.0 0.007 16.3 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_45 PF14947.6 AIC14969.1 - 0.0044 17.0 0.2 0.007 16.3 0.2 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_IclR PF09339.10 AIC14969.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain AAA_assoc_C PF09821.9 AIC14969.1 - 0.012 16.2 0.1 0.023 15.2 0.1 1.5 1 1 0 1 1 1 0 C-terminal AAA-associated domain HTH_27 PF13463.6 AIC14969.1 - 0.021 15.3 0.0 0.035 14.6 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain IF2_N PF04760.15 AIC14969.1 - 0.044 13.6 0.4 0.32 10.9 0.1 2.1 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region HTH_11 PF08279.12 AIC14969.1 - 0.051 13.5 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 HTH domain HrcA_DNA-bdg PF03444.15 AIC14969.1 - 0.054 13.1 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding NLPC_P60 PF00877.19 AIC14969.1 - 0.073 13.1 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 NlpC/P60 family HTH_6 PF01418.17 AIC14969.1 - 0.074 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain, rpiR family TFIIE_beta PF02186.15 AIC14969.1 - 0.089 13.1 0.6 0.4 11.0 0.1 2.1 1 1 1 2 2 2 0 TFIIE beta subunit core domain eRF1_1 PF03463.15 AIC14971.1 - 6.9e-21 74.6 0.1 1.2e-20 73.8 0.1 1.3 1 0 0 1 1 1 1 eRF1 domain 1 eRF1_3 PF03465.15 AIC14971.1 - 7.4e-12 45.7 0.2 2.9e-11 43.9 0.2 2.0 2 0 0 2 2 2 1 eRF1 domain 3 CutA1 PF03091.15 AIC14972.1 - 2.1e-29 101.3 0.1 2.6e-29 101.0 0.1 1.1 1 0 0 1 1 1 1 CutA1 divalent ion tolerance protein Ribosomal_L11 PF00298.19 AIC14972.1 - 0.06 13.9 0.0 0.13 12.8 0.0 1.6 2 0 0 2 2 2 0 Ribosomal protein L11, RNA binding domain DUF354 PF04007.12 AIC14974.1 - 6.5e-44 150.4 0.0 8.5e-44 150.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF354) Glyco_tran_28_C PF04101.16 AIC14974.1 - 0.0024 17.9 0.0 0.0042 17.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_4_4 PF13579.6 AIC14974.1 - 0.0033 17.9 3.8 0.0048 17.4 0.2 2.6 2 1 1 3 3 3 1 Glycosyl transferase 4-like domain LpxB PF02684.15 AIC14974.1 - 0.0036 16.2 0.0 0.0054 15.6 0.0 1.2 1 0 0 1 1 1 1 Lipid-A-disaccharide synthetase Glyco_transf_4 PF13439.6 AIC14974.1 - 0.028 14.4 0.1 0.092 12.7 0.0 2.0 2 0 0 2 2 2 0 Glycosyltransferase Family 4 Epimerase_2 PF02350.19 AIC14974.1 - 0.031 13.2 0.0 0.055 12.3 0.0 1.4 2 0 0 2 2 2 0 UDP-N-acetylglucosamine 2-epimerase YqaH PF17448.2 AIC14974.1 - 0.038 14.3 1.6 0.33 11.3 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized YqaH-like DUF2478 PF10649.9 AIC14974.1 - 0.082 12.5 0.1 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2478) 2-Hacid_dh_C PF02826.19 AIC14975.1 - 1.8e-66 222.9 0.1 2.5e-66 222.4 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AIC14975.1 - 4.9e-24 84.5 0.0 6.1e-24 84.2 0.0 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 AIC14975.1 - 4.6e-06 26.9 0.1 1.5e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase IlvN PF07991.12 AIC14975.1 - 8.8e-05 22.1 0.2 0.00053 19.6 0.0 2.2 2 1 1 3 3 3 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 AIC14975.1 - 0.00012 22.6 0.0 0.00045 20.7 0.0 2.1 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent AlaDh_PNT_C PF01262.21 AIC14975.1 - 0.011 15.1 0.0 0.024 14.0 0.0 1.5 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Shikimate_DH PF01488.20 AIC14975.1 - 0.011 15.8 0.1 0.02 14.9 0.1 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AdoHcyase_NAD PF00670.21 AIC14975.1 - 0.031 14.4 0.1 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 AIC14975.1 - 0.079 13.4 0.0 0.21 12.1 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 AIC14975.1 - 0.084 12.8 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Hexapep PF00132.24 AIC14976.1 - 7.9e-25 85.6 19.9 1.4e-08 34.1 0.5 4.2 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AIC14976.1 - 9.2e-18 63.7 13.1 9e-10 38.1 2.4 4.2 3 1 1 4 4 4 4 Hexapeptide repeat of succinyl-transferase Trm112p PF03966.16 AIC14977.1 - 1e-08 35.6 0.3 2.3e-08 34.5 0.3 1.6 1 1 0 1 1 1 1 Trm112p-like protein Methyltransf_14 PF08484.11 AIC14977.1 - 0.15 11.9 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 C-methyltransferase C-terminal domain GFO_IDH_MocA PF01408.22 AIC14978.1 - 8.8e-26 91.1 0.0 1.7e-25 90.2 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 AIC14978.1 - 0.00018 21.5 0.0 0.00039 20.4 0.0 1.6 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain IlvN PF07991.12 AIC14978.1 - 0.00025 20.7 0.0 0.0017 18.0 0.0 2.1 1 1 1 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_2 PF03446.15 AIC14978.1 - 0.012 15.7 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 AIC14978.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.6 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 AIC14978.1 - 0.022 14.1 0.0 0.046 13.1 0.0 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Aminotran_4 PF01063.19 AIC14979.1 - 5.9e-49 166.9 0.0 6.9e-49 166.7 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV Alba PF01918.21 AIC14981.1 - 7.3e-11 41.7 0.1 9.5e-11 41.4 0.1 1.2 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 AIC14981.1 - 0.077 13.0 0.9 1 9.3 0.1 2.2 1 1 1 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P HTH_AsnC-type PF13404.6 AIC14982.1 - 0.015 15.1 0.1 0.025 14.4 0.1 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain ACT_4 PF13291.6 AIC14982.1 - 0.066 13.8 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 ACT domain GerE PF00196.19 AIC14983.1 - 0.00098 18.6 0.1 0.0026 17.3 0.1 1.7 1 0 0 1 1 1 1 Bacterial regulatory proteins, luxR family AsnC_trans_reg PF01037.21 AIC14983.1 - 0.0019 18.1 0.0 0.0034 17.3 0.0 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_23 PF13384.6 AIC14983.1 - 0.0051 16.6 0.1 0.014 15.1 0.1 1.8 2 0 0 2 2 2 1 Homeodomain-like domain HTH_AsnC-type PF13404.6 AIC14983.1 - 0.0076 16.1 1.0 0.026 14.3 1.0 1.9 1 1 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIC14983.1 - 0.012 15.2 2.3 0.033 13.7 2.3 1.8 1 1 0 1 1 1 0 Winged helix-turn-helix DNA-binding Sigma70_r4_2 PF08281.12 AIC14983.1 - 0.026 14.2 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-70, region 4 RP-C PF03428.13 AIC14983.1 - 0.069 12.8 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 Replication protein C N-terminal domain DELLA PF12041.8 AIC14983.1 - 0.075 12.9 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator DELLA protein N terminal TrmB PF01978.19 AIC14983.1 - 0.14 12.0 0.2 0.25 11.3 0.2 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB He_PIG PF05345.12 AIC14984.1 - 0.15 12.3 1.1 0.48 10.6 0.5 2.2 1 1 0 1 1 1 0 Putative Ig domain CcdA PF07362.12 AIC14985.1 - 0.033 14.6 0.3 2.2 8.8 0.4 2.3 2 0 0 2 2 2 0 Post-segregation antitoxin CcdA Methyltransf_25 PF13649.6 AIC14986.1 - 1.3e-17 64.2 0.0 3.9e-17 62.8 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC14986.1 - 2.2e-16 60.0 0.0 3.5e-16 59.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC14986.1 - 7.5e-16 58.6 0.0 1.6e-15 57.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC14986.1 - 6.3e-10 39.7 0.0 1.7e-09 38.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC14986.1 - 7.9e-09 35.6 0.0 2e-07 31.0 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC14986.1 - 1.2e-07 31.4 0.0 2.8e-07 30.1 0.0 1.5 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 AIC14986.1 - 0.0017 17.8 0.0 0.0042 16.6 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase DREV PF05219.12 AIC14986.1 - 0.016 14.4 0.0 0.023 13.8 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Trm112p PF03966.16 AIC14986.1 - 0.021 15.4 0.1 0.045 14.3 0.1 1.6 1 0 0 1 1 1 0 Trm112p-like protein Methyltransf_9 PF08003.11 AIC14986.1 - 0.049 12.6 0.0 0.068 12.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) MTS PF05175.14 AIC14986.1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain PCMT PF01135.19 AIC14986.1 - 0.16 11.7 0.0 0.31 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) META PF03724.16 AIC14987.1 - 2.8e-06 27.3 0.0 3.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 META domain AsnC_trans_reg PF01037.21 AIC14988.1 - 3.9e-12 46.0 0.1 4.3e-12 45.8 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIC14988.1 - 0.03 14.4 0.1 0.041 13.9 0.1 1.2 1 0 0 1 1 1 0 NapD protein SIS PF01380.22 AIC14989.1 - 1.3e-10 41.2 1.2 0.00016 21.5 1.0 2.9 2 1 0 2 2 2 2 SIS domain SIS_2 PF13580.6 AIC14989.1 - 0.038 14.0 5.5 0.1 12.6 0.8 2.8 2 2 2 4 4 4 0 SIS domain PfkB PF00294.24 AIC14989.1 - 0.039 13.2 0.4 0.12 11.7 0.2 1.8 2 0 0 2 2 2 0 pfkB family carbohydrate kinase Rhodanese PF00581.20 AIC14990.1 - 2.4e-37 127.7 0.3 4.2e-18 65.8 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Fe_dep_repress PF01325.19 AIC14991.1 - 1.7e-21 76.2 2.1 1.7e-21 76.2 0.8 1.7 2 0 0 2 2 2 1 Iron dependent repressor, N-terminal DNA binding domain Fe_dep_repr_C PF02742.15 AIC14991.1 - 1.2e-14 54.1 0.7 2.9e-14 52.9 0.7 1.6 1 0 0 1 1 1 1 Iron dependent repressor, metal binding and dimerisation domain MarR_2 PF12802.7 AIC14991.1 - 1.9e-06 27.6 0.0 4.6e-06 26.4 0.0 1.6 1 1 0 1 1 1 1 MarR family TrmB PF01978.19 AIC14991.1 - 8.1e-05 22.4 0.1 0.00016 21.5 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIC14991.1 - 0.00012 21.5 0.0 0.00022 20.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding LexA_DNA_bind PF01726.16 AIC14991.1 - 0.00017 21.3 0.0 0.00061 19.5 0.0 1.8 2 0 0 2 2 2 1 LexA DNA binding domain HTH_Crp_2 PF13545.6 AIC14991.1 - 0.00018 21.4 0.0 0.00073 19.5 0.0 1.9 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_11 PF08279.12 AIC14991.1 - 0.00023 21.1 0.0 0.0005 19.9 0.0 1.6 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 AIC14991.1 - 0.00073 19.4 0.0 0.0021 17.9 0.0 1.8 2 0 0 2 2 1 1 MarR family HTH_DeoR PF08220.12 AIC14991.1 - 0.0017 18.1 0.1 0.035 13.9 0.0 2.7 2 1 1 3 3 3 1 DeoR-like helix-turn-helix domain Rrf2 PF02082.20 AIC14991.1 - 0.0027 18.0 0.1 0.0045 17.3 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator FeoC PF09012.10 AIC14991.1 - 0.0067 16.5 0.0 0.016 15.3 0.0 1.6 2 0 0 2 2 1 1 FeoC like transcriptional regulator HTH_27 PF13463.6 AIC14991.1 - 0.016 15.7 0.2 0.13 12.8 0.0 2.5 2 1 1 3 3 3 0 Winged helix DNA-binding domain Ribosomal_S8 PF00410.19 AIC14991.1 - 0.023 14.6 0.2 0.041 13.8 0.2 1.4 1 1 0 1 1 1 0 Ribosomal protein S8 TFIIE_alpha PF02002.17 AIC14991.1 - 0.029 14.2 0.1 0.055 13.3 0.0 1.6 2 0 0 2 2 1 0 TFIIE alpha subunit HTH_5 PF01022.20 AIC14991.1 - 0.077 12.9 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family PAX PF00292.18 AIC14991.1 - 0.08 12.9 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 'Paired box' domain HTH_23 PF13384.6 AIC14991.1 - 0.087 12.6 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain HTH_micro PF17007.5 AIC14991.1 - 0.1 11.4 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 HTH-like TALPID3 PF15324.6 AIC14991.1 - 0.11 10.1 0.1 0.13 10.0 0.1 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Nif11 PF07862.11 AIC14991.1 - 0.13 12.6 0.1 2.2 8.6 0.0 2.7 3 1 0 3 3 2 0 Nif11 domain T2SSE PF00437.20 AIC14992.1 - 8.4e-11 41.4 0.0 2.9e-10 39.7 0.0 1.9 1 1 0 1 1 1 1 Type II/IV secretion system protein KH_1 PF00013.29 AIC14992.1 - 1.9e-09 37.2 0.2 7.4e-09 35.3 0.2 2.1 1 0 0 1 1 1 1 KH domain AAA_16 PF13191.6 AIC14992.1 - 5.9e-05 23.5 0.0 0.00017 22.1 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain PIN_4 PF13638.6 AIC14992.1 - 7e-05 23.1 0.1 0.00021 21.6 0.1 1.8 1 1 0 1 1 1 1 PIN domain KH_2 PF07650.17 AIC14992.1 - 7.9e-05 22.4 0.3 0.00042 20.1 0.3 2.3 1 0 0 1 1 1 1 KH domain IstB_IS21 PF01695.17 AIC14992.1 - 0.00014 21.7 0.0 0.00028 20.7 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein MeaB PF03308.16 AIC14992.1 - 0.00018 20.6 0.0 0.00034 19.7 0.0 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 AIC14992.1 - 0.00019 21.1 0.0 0.00042 20.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIC14992.1 - 0.00023 21.7 0.0 0.00062 20.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 AIC14992.1 - 0.001 19.3 0.0 0.0082 16.4 0.0 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 AIC14992.1 - 0.0018 18.8 0.0 0.0048 17.4 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_5 PF07728.14 AIC14992.1 - 0.003 17.6 0.0 0.0071 16.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIC14992.1 - 0.0045 17.0 0.0 0.028 14.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain KH_4 PF13083.6 AIC14992.1 - 0.0045 16.8 0.4 0.029 14.2 0.1 2.6 2 0 0 2 2 2 1 KH domain AAA_30 PF13604.6 AIC14992.1 - 0.0048 16.6 0.1 0.032 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain NTPase_1 PF03266.15 AIC14992.1 - 0.0064 16.4 0.0 0.025 14.5 0.0 2.0 1 0 0 1 1 1 1 NTPase AAA_33 PF13671.6 AIC14992.1 - 0.0071 16.5 0.0 0.039 14.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain PIN PF01850.21 AIC14992.1 - 0.0076 16.8 1.0 0.018 15.6 1.0 1.6 1 0 0 1 1 1 1 PIN domain AAA_29 PF13555.6 AIC14992.1 - 0.013 15.2 0.0 0.042 13.6 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 AIC14992.1 - 0.016 15.0 0.1 0.03 14.1 0.1 1.4 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 AIC14992.1 - 0.023 15.0 0.0 0.051 13.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 AIC14992.1 - 0.024 15.0 0.1 0.097 13.1 0.0 2.1 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) PIN_5 PF08745.11 AIC14992.1 - 0.032 13.7 0.0 0.15 11.4 0.0 2.2 3 0 0 3 3 3 0 PINc domain ribonuclease Zeta_toxin PF06414.12 AIC14992.1 - 0.036 13.3 0.1 0.092 12.0 0.1 1.6 1 0 0 1 1 1 0 Zeta toxin DnaB_C PF03796.15 AIC14992.1 - 0.04 13.2 0.1 0.2 11.0 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase C terminal domain Mg_chelatase PF01078.21 AIC14992.1 - 0.043 13.2 0.1 0.13 11.7 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 AIC14992.1 - 0.044 12.9 0.0 0.082 12.1 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain PhoH PF02562.16 AIC14992.1 - 0.05 13.1 0.0 0.12 11.8 0.0 1.7 1 0 0 1 1 1 0 PhoH-like protein AAA_24 PF13479.6 AIC14992.1 - 0.061 13.0 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain KTI12 PF08433.10 AIC14992.1 - 0.068 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 NACHT PF05729.12 AIC14992.1 - 0.078 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 AIC14992.1 - 0.081 13.3 0.0 0.2 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_17 PF13207.6 AIC14992.1 - 0.093 13.2 0.2 0.32 11.4 0.2 2.0 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AIC14992.1 - 0.12 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase DEPP PF15343.6 AIC14992.1 - 0.13 12.3 0.0 0.24 11.5 0.0 1.3 1 0 0 1 1 1 0 Decidual protein induced by progesterone family PPV_E1_C PF00519.17 AIC14992.1 - 0.13 11.0 0.0 0.23 10.3 0.0 1.3 1 0 0 1 1 1 0 Papillomavirus helicase P-II PF00543.22 AIC14993.1 - 8.1e-29 100.2 0.0 9.2e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II Peptidase_M10 PF00413.24 AIC14994.1 - 2.8e-05 24.0 0.1 3.8e-05 23.6 0.1 1.3 1 1 0 1 1 1 1 Matrixin Peptidase_M66 PF10462.9 AIC14994.1 - 0.0071 15.3 1.7 0.018 14.0 1.7 1.7 1 1 0 1 1 1 1 Peptidase M66 Metallopep PF12044.8 AIC14994.1 - 0.011 14.4 0.3 0.016 13.9 0.3 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_3 PF13582.6 AIC14994.1 - 0.044 14.3 0.0 0.073 13.6 0.0 1.4 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like BSP PF04450.12 AIC14994.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase of plants and bacteria Peptidase_M24 PF00557.24 AIC14995.1 - 2e-35 122.4 0.2 2e-35 122.4 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Plexin_cytopl PF08337.12 AIC14995.1 - 0.09 11.4 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Plexin cytoplasmic RasGAP domain Nudix_N_2 PF14803.6 AIC14996.1 - 0.0025 17.7 0.5 0.0085 16.0 0.5 1.7 1 1 1 2 2 2 1 Nudix N-terminal OrfB_Zn_ribbon PF07282.11 AIC14996.1 - 0.0059 16.5 5.5 0.029 14.3 5.5 1.8 1 1 1 2 2 2 1 Putative transposase DNA-binding domain DZR PF12773.7 AIC14996.1 - 0.0086 16.1 1.0 0.012 15.6 1.0 1.3 1 1 0 1 1 1 1 Double zinc ribbon Zn-ribbon_8 PF09723.10 AIC14996.1 - 0.015 15.4 1.3 3.8 7.7 0.2 2.2 2 0 0 2 2 2 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 AIC14996.1 - 0.017 14.7 2.7 1.8 8.1 0.1 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding ADK_lid PF05191.14 AIC14996.1 - 0.044 13.8 1.3 5.7 7.0 0.1 2.3 2 0 0 2 2 2 0 Adenylate kinase, active site lid Prok-RING_1 PF14446.6 AIC14996.1 - 0.059 13.3 1.3 0.13 12.2 1.3 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 A2L_zn_ribbon PF08792.10 AIC14996.1 - 0.078 12.7 2.5 2.7 7.8 0.1 2.2 2 0 0 2 2 2 0 A2L zinc ribbon domain YdjO PF14169.6 AIC14996.1 - 0.097 12.4 2.6 6.3 6.6 0.1 2.2 1 1 1 2 2 2 0 Cold-inducible protein YdjO C1_1 PF00130.22 AIC14996.1 - 0.1 12.5 1.5 0.52 10.2 1.6 1.8 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.19 AIC14996.1 - 0.11 12.5 0.4 0.12 12.4 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_3 PF13878.6 AIC14996.1 - 0.12 12.2 1.8 8 6.4 0.2 2.2 2 0 0 2 2 2 0 zinc-finger of acetyl-transferase ESCO zf-dskA_traR PF01258.17 AIC14996.1 - 1.9 8.5 5.8 3 7.9 0.9 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger DUF1512 PF07431.12 AIC14997.1 - 2e-131 438.2 14.5 2.5e-131 437.9 14.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1512) ATP-synt_8 PF00895.20 AIC14997.1 - 0.49 10.9 1.6 0.52 10.8 0.2 1.7 2 0 0 2 2 2 0 ATP synthase protein 8 Molydop_binding PF01568.21 AIC14999.1 - 0.022 14.8 0.0 0.075 13.1 0.0 1.8 1 1 0 1 1 1 0 Molydopterin dinucleotide binding domain DUF1090 PF06476.12 AIC15000.1 - 0.00038 20.5 12.3 0.00038 20.5 12.3 3.9 1 1 3 4 4 3 2 Protein of unknown function (DUF1090) Sec34 PF04136.15 AIC15000.1 - 0.014 15.3 2.0 0.014 15.3 2.0 3.9 1 1 3 4 4 4 0 Sec34-like family NPV_P10 PF05531.12 AIC15000.1 - 0.17 12.4 11.6 24 5.5 4.3 4.5 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 AIC15000.1 - 0.4 10.7 9.7 9.1 6.3 2.5 3.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus MscS_porin PF12795.7 AIC15000.1 - 0.45 10.0 33.2 1 8.9 17.5 3.3 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain XhlA PF10779.9 AIC15000.1 - 0.79 10.0 0.1 0.79 10.0 0.1 5.2 3 2 2 5 5 5 0 Haemolysin XhlA Allexi_40kDa PF05549.11 AIC15000.1 - 2.8 7.4 24.3 0.72 9.3 3.7 3.1 1 1 2 3 3 3 0 Allexivirus 40kDa protein DUF4407 PF14362.6 AIC15000.1 - 5.1 6.4 35.9 2.5 7.4 11.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 AIC15000.1 - 5.5 7.0 28.3 1.4 8.9 6.9 3.3 1 1 2 3 3 3 0 Laminin Domain II COG2 PF06148.11 AIC15000.1 - 6.1 6.9 30.4 0.34 11.0 2.6 4.2 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 AIC15000.1 - 7 6.7 26.3 0.68 10.0 2.7 3.7 1 1 2 4 4 4 0 Protein of unknown function (DUF1664) UPF0184 PF03670.13 AIC15000.1 - 9.2 6.7 9.7 0.96 9.9 1.1 3.2 2 2 1 3 3 3 0 Uncharacterised protein family (UPF0184) DUF2748 PF10871.8 AIC15001.1 - 0.055 12.1 0.0 0.057 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2748) Peptidase_C65 PF10275.9 AIC15001.1 - 0.1 12.0 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Peptidase C65 Otubain APH PF01636.23 AIC15002.1 - 0.037 13.9 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ubie_methyltran PF01209.18 AIC15003.1 - 3.5e-19 69.1 0.0 4.4e-19 68.7 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AIC15003.1 - 4e-19 69.1 0.0 8.9e-19 68.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15003.1 - 6.3e-18 65.3 0.1 1.6e-17 64.0 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15003.1 - 5.8e-11 42.5 0.0 8.5e-11 42.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC15003.1 - 1.2e-09 38.1 0.0 1.7e-09 37.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15003.1 - 2.1e-07 31.6 0.0 4e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AIC15003.1 - 7.7e-05 22.2 0.0 0.00012 21.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 AIC15003.1 - 0.00012 21.6 0.0 0.00019 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_24 PF13578.6 AIC15003.1 - 0.0054 17.7 0.0 0.016 16.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 AIC15003.1 - 0.0086 15.7 0.0 0.016 14.8 0.0 1.4 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW Methyltransf_8 PF05148.15 AIC15003.1 - 0.084 12.7 0.0 0.13 12.1 0.0 1.2 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_32 PF13679.6 AIC15003.1 - 0.094 12.7 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 AIC15003.1 - 0.11 12.3 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UbiA PF01040.18 AIC15004.1 - 0.00021 20.7 22.0 0.00034 20.0 20.3 1.9 1 1 1 2 2 2 1 UbiA prenyltransferase family DUF98 PF01947.16 AIC15005.1 - 0.00072 19.5 0.0 0.014 15.4 0.0 2.6 1 1 0 1 1 1 1 p-hydroxybenzoic acid synthase Sde2_N_Ubi PF13019.6 AIC15005.1 - 0.0068 16.2 0.1 0.0091 15.8 0.1 1.1 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain Nairovirus_M PF07948.11 AIC15006.1 - 0.064 11.5 0.1 0.075 11.2 0.1 1.0 1 0 0 1 1 1 0 Nairovirus M polyprotein-like DUF1573 PF07610.11 AIC15007.1 - 0.049 13.7 0.1 7.1 6.7 0.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1573) Tissue_fac PF01108.17 AIC15007.1 - 0.095 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Tissue factor ComJ PF11033.8 AIC15007.1 - 0.18 11.5 0.4 8.1 6.2 0.1 2.4 1 1 1 2 2 2 0 Competence protein J (ComJ) NUDIX PF00293.28 AIC15009.1 - 1.4e-17 64.0 0.0 1.8e-17 63.6 0.0 1.0 1 0 0 1 1 1 1 NUDIX domain NUDIX_2 PF13869.6 AIC15009.1 - 0.0024 17.5 0.0 0.0031 17.1 0.0 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX_4 PF14815.6 AIC15009.1 - 0.13 12.3 0.1 0.29 11.1 0.1 1.7 1 1 0 1 1 1 0 NUDIX domain Radical_SAM PF04055.21 AIC15010.1 - 9.2e-13 48.9 0.0 1.7e-12 48.0 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily B12-binding PF02310.19 AIC15010.1 - 0.15 12.1 0.0 0.73 9.9 0.0 2.1 2 0 0 2 2 2 0 B12 binding domain NAD_binding_1 PF00175.21 AIC15012.1 - 2.8e-11 44.0 0.0 4.8e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AIC15012.1 - 1.6e-09 38.0 0.0 2.5e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AIC15012.1 - 0.057 13.5 0.1 0.11 12.6 0.1 1.8 1 1 0 1 1 1 0 Ferric reductase NAD binding domain FlgN PF05130.12 AIC15013.1 - 0.049 14.1 2.7 0.046 14.2 1.3 1.6 1 1 1 2 2 2 0 FlgN protein DUF1326 PF07040.11 AIC15016.1 - 4.4e-47 160.4 0.0 4.9e-47 160.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) AAA PF00004.29 AIC15017.1 - 2.1e-94 313.0 0.0 2.7e-47 160.5 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 AIC15017.1 - 2.1e-28 98.3 0.4 7.2e-28 96.6 0.4 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 AIC15017.1 - 9.6e-22 76.5 0.1 1.2e-11 44.2 0.0 2.7 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AIC15017.1 - 1.3e-14 54.3 0.0 1.9e-08 34.2 0.0 2.6 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIC15017.1 - 2.2e-14 54.2 0.2 1.5e-05 25.4 0.0 3.9 2 2 1 3 3 3 2 AAA ATPase domain AAA_2 PF07724.14 AIC15017.1 - 2.4e-14 53.8 0.0 1.1e-05 25.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) TIP49 PF06068.13 AIC15017.1 - 1e-10 41.4 0.1 0.00019 20.7 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 AIC15017.1 - 4.2e-10 40.0 0.3 0.0044 17.3 0.0 3.9 2 2 1 3 3 3 2 AAA domain AAA_5 PF07728.14 AIC15017.1 - 1.1e-09 38.4 0.9 0.00039 20.4 0.1 4.1 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 AIC15017.1 - 1.8e-09 37.9 0.0 0.0016 18.6 0.0 2.6 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.6 AIC15017.1 - 1.1e-08 35.1 0.0 0.0019 18.2 0.0 2.4 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AIC15017.1 - 2.6e-07 30.6 0.0 0.0084 15.9 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein TsaE PF02367.17 AIC15017.1 - 5.8e-07 29.6 0.0 0.0099 15.9 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 AIC15017.1 - 7.3e-07 29.8 0.0 0.016 15.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain Sigma54_activat PF00158.26 AIC15017.1 - 1.5e-06 28.1 0.0 0.094 12.4 0.0 3.2 3 1 0 3 3 3 2 Sigma-54 interaction domain Mg_chelatase PF01078.21 AIC15017.1 - 2.7e-06 26.9 1.3 0.035 13.5 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 AIC15017.1 - 3.4e-06 27.4 0.0 0.047 14.1 0.0 2.5 2 0 0 2 2 2 2 RNA helicase Zeta_toxin PF06414.12 AIC15017.1 - 5e-06 25.9 0.4 0.049 12.9 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin CDC48_2 PF02933.17 AIC15017.1 - 9.3e-06 25.3 0.1 4.7e-05 23.1 0.1 2.2 2 0 0 2 2 1 1 Cell division protein 48 (CDC48), domain 2 NACHT PF05729.12 AIC15017.1 - 9.5e-06 25.6 0.1 0.11 12.4 0.0 3.2 3 0 0 3 3 3 2 NACHT domain AAA_24 PF13479.6 AIC15017.1 - 9.6e-06 25.4 0.0 0.044 13.5 0.0 2.5 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 AIC15017.1 - 1.4e-05 25.7 0.1 0.11 13.0 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_7 PF12775.7 AIC15017.1 - 1.5e-05 24.6 0.0 0.051 13.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_28 PF13521.6 AIC15017.1 - 2.1e-05 24.8 0.0 0.032 14.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain Bac_DnaA PF00308.18 AIC15017.1 - 4.6e-05 23.4 0.0 0.043 13.6 0.0 2.4 2 0 0 2 2 2 1 Bacterial dnaA protein ATPase PF06745.13 AIC15017.1 - 6.8e-05 22.3 0.7 0.11 11.9 0.0 3.4 2 1 0 3 3 3 1 KaiC NB-ARC PF00931.22 AIC15017.1 - 0.0003 20.1 0.0 0.86 8.7 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain PhoH PF02562.16 AIC15017.1 - 0.00055 19.5 0.3 0.3 10.5 0.0 2.4 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 AIC15017.1 - 0.0011 18.1 0.0 0.56 9.3 0.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF815) AAA_3 PF07726.11 AIC15017.1 - 0.0013 18.6 0.0 0.74 9.7 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 AIC15017.1 - 0.0021 17.9 3.5 0.25 11.0 0.0 2.6 3 0 0 3 3 2 2 Cytidylate kinase AAA_17 PF13207.6 AIC15017.1 - 0.0021 18.5 0.0 1.4 9.3 0.0 3.6 4 0 0 4 4 3 1 AAA domain ATPase_2 PF01637.18 AIC15017.1 - 0.0021 18.0 0.0 0.57 10.0 0.0 2.8 3 0 0 3 3 2 1 ATPase domain predominantly from Archaea Guanylate_kin PF00625.21 AIC15017.1 - 0.0027 17.4 0.2 2.4 7.8 0.0 3.5 2 1 1 3 3 3 1 Guanylate kinase CPT PF07931.12 AIC15017.1 - 0.0044 16.9 0.0 0.46 10.3 0.1 2.6 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_25 PF13481.6 AIC15017.1 - 0.0048 16.5 4.9 0.98 9.0 0.2 3.4 2 2 1 4 4 4 1 AAA domain TniB PF05621.11 AIC15017.1 - 0.0051 16.2 0.0 1.9 7.9 0.0 3.0 4 0 0 4 4 3 1 Bacterial TniB protein DUF2075 PF09848.9 AIC15017.1 - 0.0077 15.5 0.0 0.7 9.1 0.0 2.6 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 AIC15017.1 - 0.0083 15.9 2.0 2.4 7.8 0.0 2.8 3 0 0 3 3 2 1 AAA domain Sigma54_activ_2 PF14532.6 AIC15017.1 - 0.012 15.7 0.0 3.2 7.9 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AFG1_ATPase PF03969.16 AIC15017.1 - 0.014 14.3 0.0 2.7 6.8 0.0 2.6 3 0 0 3 3 2 0 AFG1-like ATPase AAA_29 PF13555.6 AIC15017.1 - 0.015 15.0 0.4 2.4 8.0 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_11 PF13086.6 AIC15017.1 - 0.02 14.7 0.1 0.81 9.4 0.0 2.7 3 0 0 3 3 3 0 AAA domain Parvo_NS1 PF01057.17 AIC15017.1 - 0.025 13.7 0.1 0.6 9.2 0.0 2.1 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 NTPase_1 PF03266.15 AIC15017.1 - 0.028 14.4 0.7 17 5.3 0.0 3.7 3 1 1 4 4 4 0 NTPase AAA_19 PF13245.6 AIC15017.1 - 0.037 14.3 0.6 1.1 9.6 0.0 2.9 3 0 0 3 3 2 0 AAA domain Rad17 PF03215.15 AIC15017.1 - 0.049 13.6 0.0 17 5.3 0.0 3.1 2 1 1 3 3 3 0 Rad17 P-loop domain T2SSE PF00437.20 AIC15017.1 - 0.053 12.6 0.0 9.9 5.1 0.0 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein RsgA_GTPase PF03193.16 AIC15017.1 - 0.06 13.3 0.0 2.9 7.8 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 AIC15017.1 - 0.077 12.7 0.0 6.5 6.5 0.0 2.3 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ResIII PF04851.15 AIC15017.1 - 0.089 12.8 0.0 21 5.1 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit SKI PF01202.22 AIC15017.1 - 0.095 12.8 0.3 20 5.3 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase Vps4_C PF09336.10 AIC15017.1 - 0.17 11.9 0.2 22 5.1 0.0 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Viral_helicase1 PF01443.18 AIC15017.1 - 0.22 11.2 0.0 5 6.8 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 AIC15017.1 - 0.24 11.9 0.1 8.2 6.9 0.0 2.5 2 0 0 2 2 2 0 AAA domain Arginase PF00491.21 AIC15018.1 - 3e-21 76.2 0.0 3.7e-21 75.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family Herpes_ori_bp PF02399.15 AIC15018.1 - 0.27 9.3 0.0 0.36 8.8 0.0 1.1 1 0 0 1 1 1 0 Origin of replication binding protein FAA_hydrolase PF01557.18 AIC15020.1 - 9.6e-69 231.4 0.0 1.3e-68 230.9 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family tRNA-synt_1c PF00749.21 AIC15021.1 - 2.1e-79 266.7 0.0 2.7e-79 266.3 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 AIC15021.1 - 1.4e-30 106.4 0.0 2.4e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain polyprenyl_synt PF00348.17 AIC15022.1 - 2.3e-66 223.5 0.0 2.8e-66 223.2 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase FMN_dh PF01070.18 AIC15023.1 - 3.6e-24 85.4 0.1 9.1e-23 80.8 0.1 2.1 1 1 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 AIC15023.1 - 0.00011 21.7 0.3 0.00011 21.7 0.3 2.0 2 0 0 2 2 2 1 Nitronate monooxygenase Glu_synthase PF01645.17 AIC15023.1 - 0.00058 19.1 4.0 0.0015 17.8 4.1 1.5 1 1 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 AIC15023.1 - 0.017 14.2 7.2 0.038 13.0 0.1 3.1 2 2 2 4 4 4 0 IMP dehydrogenase / GMP reductase domain NIR_SIR PF01077.22 AIC15023.1 - 0.096 12.2 0.1 0.61 9.6 0.0 2.1 2 0 0 2 2 2 0 Nitrite and sulphite reductase 4Fe-4S domain AA_kinase PF00696.28 AIC15024.1 - 8.6e-33 113.9 2.6 1e-32 113.7 2.6 1.0 1 0 0 1 1 1 1 Amino acid kinase family TPR_1 PF00515.28 AIC15026.1 - 7.6e-30 101.5 7.4 1.7e-13 49.8 1.5 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 AIC15026.1 - 2.6e-28 95.8 1.9 1.6e-10 40.3 0.6 5.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 AIC15026.1 - 1.8e-24 83.8 7.8 2.4e-10 39.8 0.5 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 AIC15026.1 - 7.4e-21 73.6 2.0 9e-09 34.9 1.0 4.6 1 1 3 4 4 4 3 TPR repeat TPR_17 PF13431.6 AIC15026.1 - 2.6e-18 65.0 1.2 1.1e-05 25.5 0.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 AIC15026.1 - 2.1e-16 60.3 0.0 7.3e-08 32.9 0.0 3.6 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 AIC15026.1 - 2.4e-13 50.4 0.1 3.5e-07 30.6 0.0 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_9 PF13371.6 AIC15026.1 - 6.9e-13 48.6 0.0 4e-06 26.9 0.0 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 AIC15026.1 - 4e-12 45.9 0.1 0.00066 20.3 0.0 4.8 3 1 2 5 5 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 AIC15026.1 - 1e-10 41.8 0.4 5e-05 23.5 0.1 3.9 1 1 2 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 AIC15026.1 - 8.1e-10 38.8 8.5 5.5e-06 26.5 1.3 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 AIC15026.1 - 1.8e-08 33.8 0.0 0.014 15.4 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 AIC15026.1 - 4.9e-08 32.9 0.2 0.0049 16.9 0.1 3.3 2 1 1 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 AIC15026.1 - 1.2e-06 28.8 1.6 0.034 14.8 0.0 4.7 6 0 0 6 6 4 2 Tetratricopeptide repeat NARP1 PF12569.8 AIC15026.1 - 3e-05 23.2 0.2 0.022 13.7 0.0 2.2 1 1 1 2 2 2 2 NMDA receptor-regulated protein 1 TPR_10 PF13374.6 AIC15026.1 - 0.0052 16.6 0.1 0.88 9.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 AIC15026.1 - 0.027 14.9 0.5 6.6 7.2 0.1 2.6 2 1 0 2 2 2 0 Alkyl sulfatase dimerisation TPR_20 PF14561.6 AIC15026.1 - 0.028 14.7 0.0 0.13 12.6 0.0 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF2250 PF10007.9 AIC15026.1 - 0.11 12.6 0.1 0.29 11.3 0.1 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) Cytochrom_B562 PF07361.11 AIC15026.1 - 0.97 10.1 3.2 0.9 10.2 0.1 2.5 3 0 0 3 3 3 0 Cytochrome b562 Inos-1-P_synth PF01658.17 AIC15027.1 - 4.9e-16 58.9 0.0 9.1e-16 58.1 0.0 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase NAD_binding_5 PF07994.12 AIC15027.1 - 2.5e-05 23.9 0.0 0.002 17.6 0.0 2.8 2 1 1 3 3 3 1 Myo-inositol-1-phosphate synthase Pterin_bind PF00809.22 AIC15027.1 - 0.059 13.0 0.6 2.4 7.8 0.0 2.6 2 1 1 3 3 3 0 Pterin binding enzyme CoA_binding PF02629.19 AIC15027.1 - 0.06 14.0 1.3 3 8.6 0.0 2.7 1 1 1 2 2 2 0 CoA binding domain Sacchrp_dh_NADP PF03435.18 AIC15027.1 - 0.068 13.4 1.4 1.7 8.9 1.4 2.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain GFO_IDH_MocA PF01408.22 AIC15027.1 - 0.091 13.6 0.2 0.91 10.4 0.1 2.6 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold Thi4 PF01946.17 AIC15029.1 - 6.6e-63 212.1 0.0 8.2e-63 211.8 0.0 1.0 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 AIC15029.1 - 2.8e-12 46.4 0.9 2e-07 30.4 0.3 2.7 2 1 1 3 3 3 2 FAD binding domain FAD_oxidored PF12831.7 AIC15029.1 - 5.3e-10 39.2 0.0 8.2e-10 38.6 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 AIC15029.1 - 3.3e-08 33.2 0.1 5e-08 32.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 AIC15029.1 - 2.4e-07 30.9 0.1 4.8e-07 29.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 AIC15029.1 - 7.3e-07 28.7 0.1 9.2e-07 28.4 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 AIC15029.1 - 5.8e-06 25.3 0.1 7.7e-06 24.9 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein DAO PF01266.24 AIC15029.1 - 7.5e-06 25.8 3.0 0.00013 21.6 2.1 2.2 1 1 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 AIC15029.1 - 2.6e-05 23.6 1.3 3.7e-05 23.1 1.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 AIC15029.1 - 0.0002 20.5 1.3 0.002 17.2 1.3 2.0 1 1 0 1 1 1 1 Lycopene cyclase protein GIDA PF01134.22 AIC15029.1 - 0.00023 20.4 0.8 0.00037 19.7 0.8 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 AIC15029.1 - 0.0013 17.7 0.3 0.5 9.2 0.0 2.1 2 0 0 2 2 2 2 Tryptophan halogenase Amino_oxidase PF01593.24 AIC15029.1 - 0.017 14.4 0.1 0.025 13.9 0.1 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase ThiF PF00899.21 AIC15029.1 - 0.037 13.4 0.0 0.095 12.0 0.0 1.6 2 0 0 2 2 2 0 ThiF family Pyr_redox PF00070.27 AIC15029.1 - 0.066 13.8 0.1 0.42 11.2 0.3 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlphaC_C PF17480.2 AIC15029.1 - 0.13 12.3 0.0 0.32 11.1 0.0 1.6 1 0 0 1 1 1 0 AlphaC C-terminal DUF3357 PF11837.8 AIC15031.1 - 0.015 15.7 0.1 0.028 14.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Trp_oprn_chp PF09534.10 AIC15031.1 - 0.039 13.8 0.1 0.056 13.2 0.1 1.2 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) Pyr_redox_2 PF07992.14 AIC15033.1 - 8.2e-60 202.5 1.3 9.3e-60 202.3 1.3 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIC15033.1 - 9.2e-28 97.4 4.5 1.1e-24 87.2 0.3 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AIC15033.1 - 7.6e-20 71.3 0.6 7.6e-20 71.3 0.6 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AIC15033.1 - 7.8e-07 28.5 8.1 0.00035 19.8 0.4 4.5 2 2 3 5 5 5 2 FAD binding domain FAD_oxidored PF12831.7 AIC15033.1 - 4.3e-06 26.4 0.7 0.0013 18.2 0.0 2.8 2 1 1 3 3 3 2 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 AIC15033.1 - 8.7e-06 25.2 1.9 0.12 11.6 0.2 3.3 2 1 1 3 3 3 2 FAD binding domain GIDA PF01134.22 AIC15033.1 - 1.6e-05 24.2 7.5 0.027 13.6 0.2 4.7 3 2 2 5 5 5 2 Glucose inhibited division protein A DAO PF01266.24 AIC15033.1 - 1.6e-05 24.7 10.0 0.0043 16.7 0.0 4.0 2 2 1 4 4 4 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 AIC15033.1 - 1.7e-05 24.2 0.2 0.065 12.4 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) Thi4 PF01946.17 AIC15033.1 - 2.3e-05 23.8 0.5 0.0016 17.8 0.1 2.6 3 0 0 3 3 3 1 Thi4 family NAD_binding_7 PF13241.6 AIC15033.1 - 0.00022 21.6 0.5 0.014 15.8 0.6 2.4 2 1 0 2 2 2 1 Putative NAD(P)-binding HI0933_like PF03486.14 AIC15033.1 - 0.00022 20.0 1.4 0.045 12.5 0.1 3.2 3 1 0 3 3 3 1 HI0933-like protein NAD_binding_8 PF13450.6 AIC15033.1 - 0.00058 20.0 0.1 0.019 15.2 0.0 2.4 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AIC15033.1 - 0.0032 17.5 0.7 0.59 10.1 0.0 3.2 3 0 0 3 3 3 1 FAD-NAD(P)-binding Arteri_nsp7a PF16749.5 AIC15033.1 - 0.028 14.6 1.0 0.29 11.3 0.1 2.3 2 1 0 2 2 2 0 Arterivirus nonstructural protein 7 alpha Phage_SSB PF16773.5 AIC15033.1 - 0.035 14.2 0.1 0.066 13.3 0.1 1.4 1 0 0 1 1 1 0 Lactococcus phage single-stranded DNA binding protein Lycopene_cycl PF05834.12 AIC15033.1 - 0.066 12.2 0.2 0.55 9.2 0.1 2.0 2 0 0 2 2 2 0 Lycopene cyclase protein Trp_halogenase PF04820.14 AIC15033.1 - 0.082 11.7 0.7 3.7 6.3 0.1 2.8 3 0 0 3 3 3 0 Tryptophan halogenase PALP PF00291.25 AIC15034.1 - 3.4e-62 210.5 0.0 4.3e-62 210.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme TusA PF01206.17 AIC15035.1 - 5e-24 83.9 0.0 5.6e-24 83.8 0.0 1.0 1 0 0 1 1 1 1 Sulfurtransferase TusA DUF2249 PF10006.9 AIC15035.1 - 0.018 14.9 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2249) Abhydrolase_1 PF00561.20 AIC15036.1 - 1.3e-30 107.0 0.1 1.1e-27 97.3 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIC15036.1 - 3.5e-18 67.0 0.0 4.5e-18 66.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIC15036.1 - 1.4e-15 57.3 0.6 1.8e-14 53.6 0.6 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DLH PF01738.18 AIC15036.1 - 2.7e-05 23.8 0.1 0.12 11.9 0.0 2.2 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_2 PF02230.16 AIC15036.1 - 4.5e-05 23.4 0.1 0.027 14.3 0.0 2.5 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Thioesterase PF00975.20 AIC15036.1 - 6.4e-05 23.2 0.0 0.00011 22.4 0.0 1.5 1 1 0 1 1 1 1 Thioesterase domain Abhydrolase_4 PF08386.10 AIC15036.1 - 0.00014 21.9 0.0 0.00022 21.3 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Palm_thioest PF02089.15 AIC15036.1 - 0.00022 21.2 0.0 0.0014 18.5 0.0 2.0 2 0 0 2 2 2 1 Palmitoyl protein thioesterase DUF915 PF06028.11 AIC15036.1 - 0.00022 20.7 0.0 0.003 16.9 0.0 2.1 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF915) DUF1057 PF06342.12 AIC15036.1 - 0.00077 18.6 0.0 0.0013 17.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) PGAP1 PF07819.13 AIC15036.1 - 0.011 15.5 0.0 0.4 10.4 0.0 2.3 2 0 0 2 2 2 0 PGAP1-like protein FSH1 PF03959.13 AIC15036.1 - 0.013 15.2 0.4 0.99 9.0 0.1 2.7 1 1 1 2 2 2 0 Serine hydrolase (FSH1) Esterase PF00756.20 AIC15036.1 - 0.013 15.2 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Putative esterase LIP PF03583.14 AIC15036.1 - 0.013 14.8 0.0 0.56 9.5 0.0 2.1 1 1 0 1 1 1 0 Secretory lipase BAAT_C PF08840.11 AIC15036.1 - 0.044 13.7 0.1 0.2 11.6 0.1 1.9 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF726 PF05277.12 AIC15036.1 - 0.046 12.6 0.0 0.075 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF726) Lipase_3 PF01764.25 AIC15036.1 - 0.055 13.3 0.0 0.097 12.5 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_5 PF12695.7 AIC15036.1 - 0.066 13.0 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF900 PF05990.12 AIC15036.1 - 0.067 12.7 0.0 0.17 11.3 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF900) EHN PF06441.12 AIC15036.1 - 0.084 13.2 0.0 0.35 11.3 0.0 2.0 2 0 0 2 2 2 0 Epoxide hydrolase N terminus Abhydrolase_3 PF07859.13 AIC15036.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF2974 PF11187.8 AIC15036.1 - 0.17 11.4 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Ndr PF03096.14 AIC15036.1 - 0.18 10.5 0.0 0.2 10.3 0.0 1.3 1 1 0 1 1 1 0 Ndr family F420_ligase PF01996.16 AIC15037.1 - 4.1e-59 199.9 1.5 5e-59 199.6 1.5 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase UreE_N PF02814.15 AIC15037.1 - 0.12 12.0 0.3 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 UreE urease accessory protein, N-terminal domain Hydrolase PF00702.26 AIC15038.1 - 1.1e-11 45.4 0.2 1.8e-10 41.5 0.2 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AIC15038.1 - 5.6e-11 43.2 0.0 8.5e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIC15038.1 - 0.00032 20.5 0.1 0.00076 19.3 0.0 1.5 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AIC15038.1 - 0.0011 18.6 0.0 0.0014 18.2 0.0 1.2 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase HAD_2 PF13419.6 AIC15038.1 - 0.06 13.4 0.1 0.2 11.7 0.1 2.0 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase VWA_2 PF13519.6 AIC15039.1 - 2.7e-08 34.4 0.3 4.6e-07 30.5 0.0 3.0 3 1 0 3 3 3 1 von Willebrand factor type A domain KfrA_N PF11740.8 AIC15039.1 - 0.0022 18.7 5.5 0.004 17.8 5.5 1.4 1 0 0 1 1 1 1 Plasmid replication region DNA-binding N-term DUF5427 PF10310.9 AIC15039.1 - 0.026 13.5 4.1 0.037 13.0 4.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) AAA_5 PF07728.14 AIC15040.1 - 4.3e-10 39.7 0.0 7.1e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) Sigma54_activat PF00158.26 AIC15040.1 - 3e-09 36.8 0.0 1.2e-06 28.4 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_3 PF07726.11 AIC15040.1 - 7.7e-07 29.0 0.0 6e-05 22.9 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 AIC15040.1 - 8.2e-05 22.1 0.0 0.42 10.0 0.0 2.7 2 1 1 3 3 3 2 Magnesium chelatase, subunit ChlI MCM PF00493.23 AIC15040.1 - 0.00011 21.3 0.0 0.0036 16.4 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain AAA_PrkA PF08298.11 AIC15040.1 - 0.00029 19.9 0.1 0.0029 16.6 0.0 2.2 2 1 0 2 2 2 1 PrkA AAA domain AAA PF00004.29 AIC15040.1 - 0.04 14.3 0.0 2.6 8.5 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 AIC15040.1 - 0.081 13.0 0.1 1.8 8.6 0.0 2.8 3 0 0 3 3 3 0 Sigma-54 interaction domain Band_7 PF01145.25 AIC15040.1 - 0.14 12.2 3.2 1.2 9.1 3.2 2.5 1 1 0 1 1 1 0 SPFH domain / Band 7 family Ribosomal_S13 PF00416.22 AIC15042.1 - 2.3e-39 134.7 0.1 2.7e-39 134.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S13/S18 S4 PF01479.25 AIC15043.1 - 7.9e-13 47.9 4.4 9.6e-12 44.4 0.1 2.9 3 0 0 3 3 3 2 S4 domain Ribosomal_S4 PF00163.19 AIC15043.1 - 6.5e-05 23.8 2.2 8.6e-05 23.4 0.6 1.9 1 1 1 2 2 2 1 Ribosomal protein S4/S9 N-terminal domain S_layer_C PF05124.12 AIC15044.1 - 3.5e-10 40.3 0.0 6.2e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 S-layer like family, C-terminal region HTH_20 PF12840.7 AIC15044.1 - 2.7e-08 33.8 0.0 4.4e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 AIC15044.1 - 3.9e-05 23.5 0.1 6.6e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF4862 PF16154.5 AIC15044.1 - 0.014 14.8 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4862) MarR_2 PF12802.7 AIC15044.1 - 0.015 15.2 0.0 0.039 13.9 0.0 1.7 1 0 0 1 1 1 0 MarR family BcsB PF03170.13 AIC15044.1 - 0.033 12.6 0.0 0.066 11.6 0.0 1.4 1 1 0 1 1 1 0 Bacterial cellulose synthase subunit HTH_29 PF13551.6 AIC15044.1 - 0.058 13.4 0.3 0.17 11.9 0.1 1.9 2 0 0 2 2 2 0 Winged helix-turn helix HTH_5 PF01022.20 AIC15044.1 - 0.076 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family SIS PF01380.22 AIC15045.1 - 9e-52 174.4 2.3 2e-25 89.1 0.8 2.5 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 AIC15045.1 - 9.2e-21 74.4 0.0 1.8e-20 73.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AIC15045.1 - 1.5e-15 57.2 0.0 3.6e-15 56.0 0.0 1.7 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 AIC15045.1 - 7.3e-05 22.8 4.4 0.0029 17.6 0.1 3.5 2 2 1 3 3 3 1 SIS domain GATase_4 PF13230.6 AIC15045.1 - 0.00027 19.9 0.0 0.00046 19.2 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferases class-II DASH_Duo1 PF08651.10 AIC15045.1 - 0.24 11.2 0.3 21 5.0 0.1 2.7 2 0 0 2 2 2 0 DASH complex subunit Duo1 Snf7 PF03357.21 AIC15046.1 - 1e-07 31.7 0.2 1.6e-07 31.0 0.2 1.3 1 0 0 1 1 1 1 Snf7 LOH1CR12 PF10158.9 AIC15046.1 - 0.0028 17.7 0.3 0.0045 17.0 0.3 1.3 1 0 0 1 1 1 1 Tumour suppressor protein Proteasom_PSMB PF10508.9 AIC15046.1 - 0.019 13.5 0.9 0.025 13.1 0.9 1.1 1 0 0 1 1 1 0 Proteasome non-ATPase 26S subunit DUF2884 PF11101.8 AIC15046.1 - 0.056 12.9 3.2 0.086 12.3 2.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2884) Atg14 PF10186.9 AIC15046.1 - 0.07 12.2 0.8 0.089 11.9 0.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 IFT57 PF10498.9 AIC15046.1 - 0.15 11.0 4.6 0.21 10.5 4.6 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SOAR PF16533.5 AIC15046.1 - 0.4 10.7 3.7 0.55 10.2 2.9 1.6 2 0 0 2 2 2 0 STIM1 Orai1-activating region Nup88 PF10168.9 AIC15046.1 - 0.57 7.9 4.3 0.8 7.4 4.3 1.1 1 0 0 1 1 1 0 Nuclear pore component FOXP-CC PF16159.5 AIC15046.1 - 1.5 9.5 3.5 1.4 9.7 1.2 1.9 1 1 1 2 2 2 0 FOXP coiled-coil domain LPG_synthase_TM PF03706.13 AIC15048.1 - 4.2e-26 92.2 23.9 6.1e-26 91.7 23.9 1.2 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region K-cyclin_vir_C PF09080.10 AIC15048.1 - 0.0057 17.1 0.1 0.017 15.6 0.1 1.7 1 0 0 1 1 1 1 K cyclin, C terminal ATP_bind_1 PF03029.17 AIC15050.1 - 2.1e-52 178.3 0.0 2.3e-52 178.2 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 AIC15050.1 - 0.003 17.8 0.1 0.013 15.8 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AIC15050.1 - 0.0043 17.5 0.1 0.0097 16.3 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain MeaB PF03308.16 AIC15050.1 - 0.0093 15.0 0.1 0.045 12.7 0.0 1.9 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF2075 PF09848.9 AIC15050.1 - 0.019 14.2 0.0 0.031 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) CLP1_P PF16575.5 AIC15050.1 - 0.021 14.6 0.0 2.7 7.8 0.0 2.5 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 AIC15050.1 - 0.023 14.8 0.0 0.39 10.8 0.0 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_18 PF13238.6 AIC15050.1 - 0.032 14.8 0.0 0.065 13.8 0.0 1.6 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 AIC15050.1 - 0.086 12.8 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 NACHT domain TrwB_AAD_bind PF10412.9 AIC15050.1 - 0.088 11.7 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_24 PF13479.6 AIC15050.1 - 0.2 11.3 0.0 0.51 10.0 0.0 1.6 2 0 0 2 2 2 0 AAA domain GHMP_kinases_N PF00288.26 AIC15051.1 - 1.9e-12 47.3 3.9 5.5e-12 45.7 3.9 1.9 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 AIC15051.1 - 1.2e-08 35.1 0.1 2.6e-08 34.1 0.1 1.5 1 0 0 1 1 1 1 GHMP kinases C terminal ECH_1 PF00378.20 AIC15052.1 - 4.9e-59 199.7 5.8 2.1e-55 187.8 5.0 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 AIC15052.1 - 7.5e-40 137.4 2.4 2.3e-37 129.3 0.9 2.0 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 AIC15052.1 - 0.043 13.8 0.0 0.27 11.2 0.0 2.1 2 0 0 2 2 2 0 Peptidase family S49 Arginase PF00491.21 AIC15053.1 - 3.4e-60 203.9 0.2 3.9e-60 203.7 0.2 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 AIC15053.1 - 0.12 12.6 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 UPF0489 domain ABC_membrane PF00664.23 AIC15055.1 - 0.073 12.7 0.1 0.097 12.3 0.1 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region DUF5593 PF18007.1 AIC15055.1 - 0.11 13.2 0.0 0.13 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5593) E1-E2_ATPase PF00122.20 AIC15056.1 - 3.6e-53 179.8 3.0 3.6e-53 179.8 3.0 1.9 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AIC15056.1 - 1.4e-45 156.2 5.5 2.4e-45 155.4 5.5 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 AIC15056.1 - 8.2e-27 93.4 0.2 3.3e-16 59.5 0.4 3.0 2 0 0 2 2 2 2 Heavy-metal-associated domain HAD PF12710.7 AIC15056.1 - 8.6e-06 26.3 0.2 0.00018 22.0 0.2 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 AIC15056.1 - 0.00011 22.3 0.1 0.065 13.3 0.0 3.4 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIC15056.1 - 0.00016 21.6 5.2 0.012 15.4 1.6 3.0 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hint_2 PF13403.6 AIC15056.1 - 0.088 13.1 0.1 0.24 11.7 0.1 1.7 1 0 0 1 1 1 0 Hint domain PCB_OB PF17092.5 AIC15056.1 - 0.15 12.8 0.8 0.88 10.3 0.1 2.6 2 0 0 2 2 2 0 Penicillin-binding protein OB-like domain PCP_red PF08369.10 AIC15056.1 - 0.15 12.3 0.3 0.43 10.8 0.3 1.8 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit PAC2 PF09754.9 AIC15058.1 - 9.9e-27 94.3 0.0 1.2e-26 94.1 0.0 1.0 1 0 0 1 1 1 1 PAC2 family DUF3892 PF13031.6 AIC15059.1 - 0.11 13.2 0.1 0.19 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3892) BAP PF06639.11 AIC15059.1 - 0.12 12.7 0.3 0.32 11.4 0.0 1.8 2 0 0 2 2 2 0 Basal layer antifungal peptide (BAP) DNA_ligase_A_M PF01068.21 AIC15062.1 - 1e-55 188.5 0.1 1.8e-55 187.7 0.1 1.4 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 AIC15062.1 - 1.9e-33 116.2 0.2 5.6e-33 114.7 0.0 1.8 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 AIC15062.1 - 4.9e-21 75.2 0.0 1.2e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region RNA_ligase PF09414.10 AIC15062.1 - 8.7e-08 32.6 0.0 1.5e-07 31.8 0.0 1.4 1 0 0 1 1 1 1 RNA ligase Ribosomal_S25 PF03297.15 AIC15063.1 - 3.6e-10 40.0 6.9 4.4e-10 39.7 6.9 1.1 1 0 0 1 1 1 1 S25 ribosomal protein TrmB PF01978.19 AIC15063.1 - 0.0015 18.4 0.3 0.0021 17.9 0.3 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIC15063.1 - 0.008 16.1 0.0 0.012 15.5 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 AIC15063.1 - 0.011 15.2 0.1 0.016 14.7 0.1 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Rrf2 PF02082.20 AIC15063.1 - 0.039 14.3 0.5 0.063 13.6 0.5 1.3 1 1 0 1 1 1 0 Transcriptional regulator DUF4320 PF14208.6 AIC15063.1 - 0.058 13.5 0.3 0.16 12.1 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) MarR_2 PF12802.7 AIC15063.1 - 0.071 13.0 0.0 0.081 12.8 0.0 1.2 1 0 0 1 1 1 0 MarR family HTH_IclR PF09339.10 AIC15063.1 - 0.11 12.4 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 IclR helix-turn-helix domain Cyclophil_like PF04126.13 AIC15064.1 - 3.4e-08 33.3 0.0 4.9e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin-like Cyclophil_like2 PF18050.1 AIC15064.1 - 4.8e-05 23.3 0.0 6.5e-05 22.9 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin-like family DUF3830 PF12903.7 AIC15064.1 - 0.044 13.5 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3830) RNA_pol_Rpb6 PF01192.22 AIC15066.1 - 1.3e-08 34.6 0.6 2.7e-08 33.6 0.0 1.8 2 1 0 2 2 2 1 RNA polymerase Rpb6 CABS1 PF15367.6 AIC15066.1 - 0.079 12.1 0.0 0.095 11.8 0.0 1.0 1 0 0 1 1 1 0 Calcium-binding and spermatid-specific protein 1 Pyr_redox_2 PF07992.14 AIC15067.1 - 9.4e-52 176.1 0.2 1.4e-51 175.5 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AIC15067.1 - 1.6e-25 89.5 0.1 3e-25 88.6 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 AIC15067.1 - 1.5e-14 54.3 1.9 2.1e-11 44.2 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIC15067.1 - 4.6e-11 42.5 1.1 2.6e-08 33.5 0.0 2.3 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 AIC15067.1 - 1.2e-07 31.2 0.8 4.9e-05 22.6 0.0 3.2 3 1 1 4 4 4 1 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 AIC15067.1 - 5.6e-05 22.4 5.1 0.0003 20.0 1.4 2.8 2 1 1 3 3 3 1 FAD binding domain GIDA PF01134.22 AIC15067.1 - 9.4e-05 21.6 0.6 0.0002 20.6 0.1 1.8 2 0 0 2 2 2 1 Glucose inhibited division protein A 3HCDH_N PF02737.18 AIC15067.1 - 0.0073 16.2 0.4 1.1 9.2 0.0 2.4 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain FAD_oxidored PF12831.7 AIC15067.1 - 0.024 14.0 0.2 0.044 13.1 0.2 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase HI0933_like PF03486.14 AIC15067.1 - 0.031 13.0 0.9 0.12 11.0 0.4 2.0 2 0 0 2 2 2 0 HI0933-like protein XdhC_C PF13478.6 AIC15067.1 - 0.071 13.6 0.0 0.31 11.6 0.0 2.0 2 0 0 2 2 2 0 XdhC Rossmann domain NAD_binding_8 PF13450.6 AIC15067.1 - 0.089 13.0 2.9 1.5 9.1 0.4 2.6 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain Lycopene_cycl PF05834.12 AIC15067.1 - 0.51 9.3 1.7 0.57 9.2 0.7 1.6 2 0 0 2 2 2 0 Lycopene cyclase protein HTH_20 PF12840.7 AIC15069.1 - 2.3e-07 30.8 0.0 4.4e-07 29.9 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_45 PF14947.6 AIC15069.1 - 3.4e-06 26.9 0.1 9.1e-06 25.6 0.1 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix MarR_2 PF12802.7 AIC15069.1 - 6.1e-06 26.0 0.1 3.7e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 MarR family DUF4423 PF14394.6 AIC15069.1 - 2.9e-05 23.8 0.1 5.8e-05 22.9 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) HTH_5 PF01022.20 AIC15069.1 - 0.00094 19.0 0.2 0.0025 17.6 0.2 1.8 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 AIC15069.1 - 0.0017 18.2 0.0 0.0079 16.1 0.0 2.1 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIC15069.1 - 0.0023 18.4 0.0 0.0046 17.4 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain Regulator_TrmB PF11495.8 AIC15069.1 - 0.0027 16.9 0.0 0.0038 16.5 0.0 1.2 1 0 0 1 1 1 1 Archaeal transcriptional regulator TrmB HTH_11 PF08279.12 AIC15069.1 - 0.0062 16.5 0.1 0.013 15.4 0.1 1.5 1 0 0 1 1 1 1 HTH domain MarR PF01047.22 AIC15069.1 - 0.0064 16.4 0.5 0.019 14.9 0.1 1.9 2 0 0 2 2 2 1 MarR family HTH_24 PF13412.6 AIC15069.1 - 0.0069 15.9 0.2 0.016 14.7 0.2 1.7 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding FtsK_gamma PF09397.10 AIC15069.1 - 0.017 14.9 0.0 0.039 13.8 0.0 1.6 1 0 0 1 1 1 0 Ftsk gamma domain Fe_dep_repress PF01325.19 AIC15069.1 - 0.028 14.6 0.1 0.097 12.9 0.0 1.9 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain DUF2250 PF10007.9 AIC15069.1 - 0.032 14.4 0.2 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_Crp_2 PF13545.6 AIC15069.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Mrr_N PF14338.6 AIC15069.1 - 0.055 13.6 0.0 0.32 11.2 0.0 2.2 2 1 0 2 2 2 0 Mrr N-terminal domain DUF1724 PF08350.10 AIC15069.1 - 0.1 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1724) HTH_IclR PF09339.10 AIC15069.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain XRCC4 PF06632.12 AIC15069.1 - 0.24 10.2 1.4 0.25 10.2 0.3 1.5 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Phage_holin_3_6 PF07332.11 AIC15070.1 - 0.00015 21.8 0.3 0.00017 21.6 0.3 1.0 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III DUF998 PF06197.13 AIC15070.1 - 0.00053 19.6 1.7 0.0006 19.5 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF998) DUF2339 PF10101.9 AIC15070.1 - 0.012 14.3 2.7 0.014 14.0 2.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2339) DUF202 PF02656.15 AIC15070.1 - 0.11 13.0 9.2 0.81 10.2 7.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF202) DUF2207 PF09972.9 AIC15070.1 - 0.11 11.3 0.3 0.11 11.2 0.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4781 PF16013.5 AIC15070.1 - 0.12 11.1 0.4 0.13 11.1 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF872 PF05915.12 AIC15070.1 - 0.14 12.3 1.5 0.2 11.8 0.5 1.6 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF872) TMEM51 PF15345.6 AIC15070.1 - 0.19 11.6 0.0 0.2 11.4 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 SdpI PF13630.6 AIC15070.1 - 0.32 11.2 3.6 0.45 10.7 3.6 1.3 1 0 0 1 1 1 0 SdpI/YhfL protein family HTH_3 PF01381.22 AIC15071.1 - 1.9e-05 24.6 0.2 5.7e-05 23.1 0.1 1.7 2 0 0 2 2 2 1 Helix-turn-helix HTH_37 PF13744.6 AIC15071.1 - 0.0024 17.8 0.0 0.0059 16.5 0.0 1.7 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_19 PF12844.7 AIC15071.1 - 0.0065 16.5 0.1 0.052 13.6 0.2 2.1 1 1 1 2 2 2 1 Helix-turn-helix domain YdaS_antitoxin PF15943.5 AIC15071.1 - 0.0071 16.2 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT MarR_2 PF12802.7 AIC15071.1 - 0.026 14.4 0.0 2.7 7.9 0.0 2.4 2 0 0 2 2 2 0 MarR family P22_Cro PF14549.6 AIC15071.1 - 0.029 14.2 0.0 0.075 12.9 0.0 1.7 2 0 0 2 2 2 0 DNA-binding transcriptional regulator Cro Sigma70_r4_2 PF08281.12 AIC15071.1 - 0.053 13.2 0.1 0.23 11.2 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_26 PF13443.6 AIC15071.1 - 0.068 13.6 0.1 0.16 12.5 0.1 1.6 2 0 0 2 2 2 0 Cro/C1-type HTH DNA-binding domain F5_F8_type_C PF00754.25 AIC15072.1 - 4e-17 62.5 4.0 4e-17 62.5 4.0 2.8 3 1 0 3 3 3 1 F5/8 type C domain Sad1_UNC PF07738.13 AIC15072.1 - 0.011 15.8 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Sad1 / UNC-like C-terminal HYR PF02494.16 AIC15072.1 - 0.078 13.3 0.1 0.32 11.4 0.0 2.0 2 0 0 2 2 2 0 HYR domain Big_7 PF17957.1 AIC15072.1 - 1 10.1 12.9 0.2 12.5 5.3 3.3 2 1 1 3 3 3 0 Bacterial Ig domain ADH_N PF08240.12 AIC15073.1 - 2e-23 82.3 1.6 3.6e-23 81.5 1.6 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIC15073.1 - 9.9e-22 77.3 1.2 1.2e-21 77.0 0.0 1.8 3 0 0 3 3 3 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AIC15073.1 - 8.1e-10 38.5 0.0 1.2e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 AIC15073.1 - 4.6e-05 24.5 0.0 7.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase AlaDh_PNT_C PF01262.21 AIC15073.1 - 0.0063 15.8 0.2 0.37 10.1 0.0 2.2 1 1 1 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AIC15073.1 - 0.074 11.7 0.1 0.13 11.0 0.1 1.3 1 0 0 1 1 1 0 HI0933-like protein DeoC PF01791.9 AIC15074.1 - 6.2e-21 75.1 0.2 1.4e-20 73.9 0.0 1.6 2 0 0 2 2 2 1 DeoC/LacD family aldolase ThiG PF05690.14 AIC15074.1 - 0.071 12.4 0.1 0.089 12.1 0.1 1.3 1 0 0 1 1 1 0 Thiazole biosynthesis protein ThiG SseB_C PF14581.6 AIC15074.1 - 0.14 12.2 0.1 0.29 11.2 0.1 1.5 1 0 0 1 1 1 0 SseB protein C-terminal domain SnoaL_3 PF13474.6 AIC15075.1 - 1.5e-11 44.6 0.0 1.9e-11 44.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIC15075.1 - 2.4e-06 27.9 0.0 2.9e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_4 PF13577.6 AIC15075.1 - 0.00036 20.7 0.0 0.00047 20.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain CaMKII_AD PF08332.10 AIC15075.1 - 0.024 14.8 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain DUF3804 PF12707.7 AIC15075.1 - 0.11 12.3 0.1 0.18 11.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3804) TPP_enzyme_N PF02776.18 AIC15076.1 - 1.2e-60 204.1 1.0 7.4e-60 201.5 0.2 2.2 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain TPP_enzyme_M PF00205.22 AIC15076.1 - 1.6e-48 164.0 0.1 3.4e-48 162.8 0.1 1.6 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_C PF02775.21 AIC15076.1 - 4.2e-45 153.3 0.7 8.2e-44 149.1 0.4 2.7 2 1 0 2 2 2 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain ALS_ss_C PF10369.9 AIC15077.1 - 2.5e-28 98.1 1.6 2e-26 92.0 0.0 2.9 2 1 1 3 3 3 1 Small subunit of acetolactate synthase ACT_5 PF13710.6 AIC15077.1 - 3e-18 65.4 0.7 6.4e-18 64.4 0.7 1.6 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 AIC15077.1 - 6.4e-17 61.0 0.1 1.3e-16 60.0 0.1 1.5 1 0 0 1 1 1 1 ACT domain ACT_4 PF13291.6 AIC15077.1 - 5.9e-07 30.0 0.8 1.2e-06 29.0 0.8 1.5 1 0 0 1 1 1 1 ACT domain NIL PF09383.10 AIC15077.1 - 0.0067 16.2 0.4 0.89 9.4 0.1 2.3 2 0 0 2 2 2 1 NIL domain Saccharop_dh_N PF04455.12 AIC15077.1 - 0.015 15.6 0.4 0.031 14.7 0.3 1.5 1 1 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region NCD2 PF04905.13 AIC15077.1 - 0.081 12.9 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) ACT_6 PF13740.6 AIC15077.1 - 0.086 12.8 0.2 1.6 8.8 0.1 2.3 2 0 0 2 2 2 0 ACT domain HMGL-like PF00682.19 AIC15078.1 - 1.4e-88 296.9 3.2 1.4e-88 296.9 3.2 1.6 2 0 0 2 2 2 1 HMGL-like LeuA_dimer PF08502.10 AIC15078.1 - 7.8e-31 106.7 3.2 1.7e-30 105.6 3.2 1.6 1 0 0 1 1 1 1 LeuA allosteric (dimerisation) domain Iso_dh PF00180.20 AIC15079.1 - 2.5e-98 329.4 0.3 2.9e-98 329.2 0.3 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase PdxA PF04166.12 AIC15079.1 - 0.0056 16.1 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Pyridoxal phosphate biosynthetic protein PdxA zf-B_box PF00643.24 AIC15080.1 - 5.8 7.2 13.0 2 8.6 7.9 2.0 1 1 1 2 2 2 0 B-box zinc finger MEDS PF14417.6 AIC15081.1 - 1.2e-11 44.7 0.2 2.7e-11 43.6 0.0 1.6 2 0 0 2 2 2 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Get5_C PF18514.1 AIC15081.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.6 1 0 0 1 1 1 0 Get5 C-terminal domain CPSase_sm_chain PF00988.22 AIC15083.1 - 1.2e-49 167.4 0.0 1.9e-49 166.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase small chain, CPSase domain GATase PF00117.28 AIC15083.1 - 3.1e-44 151.0 0.0 4.6e-44 150.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIC15083.1 - 4.8e-09 36.3 0.4 0.00049 19.9 0.1 2.3 1 1 1 2 2 2 2 Peptidase C26 CPSase_L_D2 PF02786.17 AIC15084.1 - 2.4e-107 357.2 0.1 1e-74 250.6 0.1 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 AIC15084.1 - 5.7e-39 133.2 0.0 1.1e-38 132.2 0.0 1.6 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Dala_Dala_lig_C PF07478.13 AIC15084.1 - 1.7e-14 53.9 0.4 1.3e-10 41.2 0.0 2.5 2 0 0 2 2 2 2 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 AIC15084.1 - 2.6e-14 53.1 0.6 5.6e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp domain MGS PF02142.22 AIC15084.1 - 1.1e-13 51.2 0.1 5.8e-13 48.8 0.0 2.4 3 0 0 3 3 2 1 MGS-like domain ATPgrasp_Ter PF15632.6 AIC15084.1 - 2.1e-11 43.7 0.0 9.6e-08 31.8 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 AIC15084.1 - 1.5e-06 28.2 0.1 0.00015 21.6 0.0 2.8 2 1 0 2 2 2 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain ATP-grasp_5 PF13549.6 AIC15084.1 - 0.00035 20.1 0.1 0.56 9.6 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain RimK PF08443.11 AIC15084.1 - 0.002 17.8 0.1 0.27 10.8 0.0 2.6 2 1 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 AIC15084.1 - 0.0022 18.0 0.1 0.049 13.7 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain Peripla_BP_6 PF13458.6 AIC15084.1 - 0.11 12.1 0.0 2.8 7.5 0.0 2.4 2 0 0 2 2 2 0 Periplasmic binding protein Radical_SAM PF04055.21 AIC15085.1 - 3.2e-12 47.2 0.1 5.2e-12 46.5 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AIC15085.1 - 5.5e-07 29.7 0.1 9.8e-07 28.9 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 AIC15085.1 - 0.00022 21.5 0.0 0.00044 20.5 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPASM PF13186.6 AIC15085.1 - 0.00094 19.6 0.9 0.0029 18.1 0.9 1.9 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Metallophos PF00149.28 AIC15086.1 - 1.6e-08 35.3 1.3 7.4e-08 33.1 1.3 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AIC15086.1 - 2.3e-08 34.4 0.1 3.4e-08 33.9 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain SWIM PF04434.17 AIC15087.1 - 0.0025 17.5 0.2 0.0039 16.8 0.2 1.3 1 0 0 1 1 1 1 SWIM zinc finger GARS_A PF01071.19 AIC15088.1 - 4.6e-78 261.5 0.5 6.6e-78 261.0 0.5 1.2 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_N PF02844.15 AIC15088.1 - 3e-31 108.1 0.0 7.5e-31 106.8 0.0 1.7 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, N domain GARS_C PF02843.16 AIC15088.1 - 4.5e-28 97.3 3.0 5e-28 97.2 1.2 2.1 2 0 0 2 2 2 1 Phosphoribosylglycinamide synthetase, C domain ATP-grasp_3 PF02655.14 AIC15088.1 - 1.3e-06 28.6 0.0 2.6e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp PF02222.22 AIC15088.1 - 2.9e-05 23.7 0.1 6.8e-05 22.5 0.1 1.6 1 0 0 1 1 1 1 ATP-grasp domain RimK PF08443.11 AIC15088.1 - 3.6e-05 23.4 0.0 0.00038 20.1 0.1 2.1 2 0 0 2 2 2 1 RimK-like ATP-grasp domain CPSase_L_D2 PF02786.17 AIC15088.1 - 5.7e-05 22.7 0.5 0.00031 20.3 0.5 2.0 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Dala_Dala_lig_C PF07478.13 AIC15088.1 - 0.00031 20.4 0.0 0.00049 19.7 0.0 1.3 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATPgrasp_ST PF14397.6 AIC15088.1 - 0.00064 19.1 0.1 0.0051 16.1 0.1 2.0 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp ATP-grasp_2 PF08442.10 AIC15088.1 - 0.0059 16.2 0.6 0.015 14.9 0.6 1.6 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_4 PF13535.6 AIC15088.1 - 0.027 14.1 0.0 0.05 13.2 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain 5-FTHF_cyc-lig PF01812.20 AIC15089.1 - 1.3e-33 116.4 0.0 1.6e-33 116.2 0.0 1.0 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family THF_DHG_CYH_C PF02882.19 AIC15090.1 - 1.4e-63 213.0 0.5 2e-63 212.5 0.5 1.2 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain THF_DHG_CYH PF00763.23 AIC15090.1 - 3.1e-40 137.1 0.2 4.9e-40 136.4 0.2 1.3 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain AlaDh_PNT_C PF01262.21 AIC15090.1 - 0.00011 21.5 0.3 0.00033 20.0 0.1 1.7 2 0 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain Semialdhyde_dh PF01118.24 AIC15090.1 - 0.0024 18.3 0.1 0.0092 16.4 0.0 1.9 2 0 0 2 2 2 1 Semialdehyde dehydrogenase, NAD binding domain OCD_Mu_crystall PF02423.15 AIC15090.1 - 0.0046 15.9 0.1 0.0072 15.3 0.1 1.2 1 0 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family Shikimate_DH PF01488.20 AIC15090.1 - 0.0061 16.6 0.5 0.018 15.1 0.2 1.9 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase Hydrolase PF00702.26 AIC15090.1 - 0.022 15.1 0.2 0.044 14.1 0.2 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Sacchrp_dh_NADP PF03435.18 AIC15090.1 - 0.15 12.3 0.7 0.33 11.2 0.1 1.9 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain CstA PF02554.14 AIC15091.1 - 0.0057 15.6 0.2 0.0064 15.4 0.2 1.1 1 0 0 1 1 1 1 Carbon starvation protein CstA DUF4381 PF14316.6 AIC15091.1 - 0.038 14.2 2.8 0.26 11.5 2.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) Nop PF01798.18 AIC15091.1 - 0.15 11.5 0.0 0.18 11.3 0.0 1.1 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin Glycos_transf_2 PF00535.26 AIC15092.1 - 1.5e-18 67.2 0.5 2.2e-18 66.6 0.5 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIC15092.1 - 2.2e-06 27.7 0.1 2.7e-05 24.2 0.0 2.0 1 1 1 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIC15092.1 - 0.0011 19.4 0.1 0.0023 18.4 0.1 1.6 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 AIC15092.1 - 0.057 12.9 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 Asn_synthase PF00733.21 AIC15093.1 - 1.1e-25 91.0 0.0 1.4e-25 90.7 0.0 1.0 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.16 AIC15093.1 - 0.034 13.0 0.1 0.048 12.4 0.1 1.2 1 0 0 1 1 1 0 tRNA methyl transferase NAD_synthase PF02540.17 AIC15093.1 - 0.1 11.7 0.0 0.19 10.8 0.0 1.4 1 0 0 1 1 1 0 NAD synthase Mu-like_Pro PF10123.9 AIC15094.1 - 0.034 13.7 8.6 0.012 15.2 5.8 1.6 1 1 0 1 1 1 0 Mu-like prophage I protein ABC_tran_CTD PF16326.5 AIC15094.1 - 0.086 13.1 10.6 2.4 8.4 0.4 3.6 2 1 0 2 2 2 0 ABC transporter C-terminal domain MutS_III PF05192.18 AIC15094.1 - 0.84 9.8 5.6 0.71 10.1 4.2 1.4 1 1 0 1 1 1 0 MutS domain III Matrilin_ccoil PF10393.9 AIC15094.1 - 3.6 7.5 6.7 2.1 8.3 0.1 2.9 2 1 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Ribosomal_L37e PF01907.19 AIC15095.1 - 5.6e-23 80.9 14.0 6e-23 80.8 14.0 1.0 1 0 0 1 1 1 1 Ribosomal protein L37e HypA PF01155.19 AIC15095.1 - 0.00046 20.2 0.8 0.00048 20.1 0.8 1.1 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 AIC15095.1 - 0.0048 16.9 1.2 0.0057 16.6 1.2 1.2 1 0 0 1 1 1 1 Double zinc ribbon Ribosomal_S14 PF00253.21 AIC15095.1 - 0.0078 15.9 0.5 0.0078 15.9 0.5 2.1 1 1 1 2 2 2 1 Ribosomal protein S14p/S29e Ephrin_rec_like PF07699.13 AIC15095.1 - 0.0085 15.8 1.6 0.013 15.2 1.6 1.4 1 0 0 1 1 1 1 Putative ephrin-receptor like zf-ribbon_3 PF13248.6 AIC15095.1 - 0.009 15.4 2.3 0.46 10.0 0.1 2.1 2 0 0 2 2 2 2 zinc-ribbon domain Rubredoxin_2 PF18073.1 AIC15095.1 - 0.032 13.9 4.7 1.9 8.3 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain DNA_RNApol_7kD PF03604.13 AIC15095.1 - 0.045 13.4 3.5 0.045 13.4 3.5 2.2 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zn-ribbon_14 PF16503.5 AIC15095.1 - 0.066 12.7 6.3 1.1 8.8 0.9 2.2 2 0 0 2 2 2 0 Zinc-ribbon NRDD PF13597.6 AIC15095.1 - 0.068 11.9 2.7 0.064 12.0 2.7 1.0 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase zinc_ribbon_13 PF09855.9 AIC15095.1 - 0.11 12.7 3.6 3 8.1 0.3 2.2 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-Mss51 PF13824.6 AIC15095.1 - 0.17 12.0 4.9 12 6.1 4.9 2.1 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 zinc_ribbon_4 PF13717.6 AIC15095.1 - 0.19 11.7 7.6 0.59 10.1 0.8 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AIC15095.1 - 0.27 11.0 7.3 0.9 9.4 7.3 1.8 1 1 0 1 1 1 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIC15095.1 - 0.54 10.2 7.1 0.78 9.7 7.0 1.4 1 1 0 1 1 1 0 Putative transposase DNA-binding domain DUF35_N PF12172.8 AIC15095.1 - 0.71 9.8 7.3 1.2 9.1 7.3 1.3 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) UPF0547 PF10571.9 AIC15095.1 - 2.6 8.2 6.7 9.6 6.4 1.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 LSM PF01423.22 AIC15096.1 - 3.6e-23 81.0 1.3 4e-23 80.9 1.3 1.0 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AIC15096.1 - 0.0012 19.0 0.1 0.0014 18.7 0.1 1.2 1 0 0 1 1 1 1 Ataxin 2 SM domain DUF150_C PF17384.2 AIC15096.1 - 0.086 13.0 0.1 0.12 12.5 0.1 1.3 1 1 0 1 1 1 0 RimP C-terminal SH3 domain Creatininase PF02633.14 AIC15097.1 - 1.9e-63 214.2 1.1 2.3e-63 213.9 1.1 1.0 1 0 0 1 1 1 1 Creatinine amidohydrolase Formyl_trans_N PF00551.19 AIC15098.1 - 3.1e-46 157.4 0.0 4.4e-46 156.9 0.0 1.2 1 0 0 1 1 1 1 Formyl transferase ACT_6 PF13740.6 AIC15098.1 - 1.4e-08 34.6 0.1 2.6e-08 33.7 0.1 1.4 1 0 0 1 1 1 1 ACT domain ACT PF01842.25 AIC15098.1 - 1.2e-05 24.9 0.2 4.5e-05 23.1 0.1 2.1 2 0 0 2 2 2 1 ACT domain ACT_4 PF13291.6 AIC15098.1 - 3.4e-05 24.3 1.9 9.2e-05 23.0 0.2 2.5 4 0 0 4 4 4 1 ACT domain SPOR PF05036.13 AIC15102.1 - 0.15 12.5 0.0 0.22 11.9 0.0 1.3 1 0 0 1 1 1 0 Sporulation related domain DUF2207 PF09972.9 AIC15103.1 - 0.0032 16.3 0.0 0.0039 16.0 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) CemA PF03040.14 AIC15103.1 - 0.0032 17.4 0.3 2.3 8.1 0.0 2.1 2 0 0 2 2 2 2 CemA family Sigma_reg_N PF13800.6 AIC15103.1 - 0.027 14.8 5.1 0.52 10.6 2.9 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal SUR7 PF06687.12 AIC15103.1 - 0.087 12.4 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 SUR7/PalI family DUF4083 PF13314.6 AIC15103.1 - 0.6 10.1 0.1 0.6 10.1 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4083) DUF3974 PF13120.6 AIC15103.1 - 1.9 8.6 4.6 6.4 6.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3974) HTH_45 PF14947.6 AIC15104.1 - 1.2e-06 28.4 1.5 1.4e-06 28.1 1.5 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIC15104.1 - 0.013 15.5 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 MarR family DUF2680 PF10925.8 AIC15104.1 - 0.059 13.4 0.7 6.1 6.9 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2680) Polyketide_cyc2 PF10604.9 AIC15106.1 - 3.6e-17 63.0 0.2 3.9e-17 62.8 0.2 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIC15106.1 - 5.1e-08 33.2 0.0 1.5e-07 31.7 0.0 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.13 AIC15106.1 - 0.001 18.8 0.0 0.002 17.9 0.0 1.5 1 1 0 1 1 1 1 Carbon monoxide dehydrogenase subunit G (CoxG) DUF2505 PF10698.9 AIC15106.1 - 0.002 18.2 0.2 0.0077 16.3 0.2 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2505) AHSA1 PF08327.11 AIC15106.1 - 0.0083 16.3 0.0 0.039 14.2 0.0 2.0 1 1 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein DUF1857 PF08982.11 AIC15106.1 - 0.043 13.7 0.0 0.049 13.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1857) RSN1_7TM PF02714.15 AIC15107.1 - 0.055 12.8 0.1 0.071 12.4 0.1 1.1 1 0 0 1 1 1 0 Calcium-dependent channel, 7TM region, putative phosphate DUF543 PF04418.12 AIC15107.1 - 0.27 11.2 1.4 0.71 9.9 1.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF543) SHOCT PF09851.9 AIC15109.1 - 3.4e-08 33.0 0.2 4.5e-08 32.6 0.2 1.2 1 0 0 1 1 1 1 Short C-terminal domain DUF1707 PF08044.11 AIC15109.1 - 0.016 15.2 0.3 0.021 14.9 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1707) DUF4381 PF14316.6 AIC15109.1 - 0.071 13.3 1.0 0.09 13.0 0.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4381) UL2 PF08196.11 AIC15109.1 - 1.2 9.1 5.9 2.1 8.3 5.9 1.4 1 0 0 1 1 1 0 UL2 protein HxlR PF01638.17 AIC15110.1 - 2.6e-22 78.5 0.1 3.1e-22 78.2 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.6 AIC15110.1 - 9.7e-05 22.5 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 AIC15110.1 - 0.071 13.1 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 MarR family HTH_20 PF12840.7 AIC15110.1 - 0.083 13.0 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 Helix-turn-helix domain Glyco_transf_4 PF13439.6 AIC15111.1 - 4.2e-12 46.4 1.0 4.1e-11 43.2 1.0 2.1 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 AIC15111.1 - 2.1e-08 34.7 3.7 2.2e-07 31.4 3.7 2.1 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 AIC15111.1 - 0.0021 18.1 0.0 0.0044 17.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_trans_1_2 PF13524.6 AIC15111.1 - 0.0025 18.2 0.0 0.0094 16.3 0.0 2.0 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AIC15111.1 - 0.023 15.1 0.0 0.053 13.9 0.0 1.6 1 0 0 1 1 1 0 Glycosyl transferases group 1 PIG-L PF02585.17 AIC15111.1 - 0.11 13.1 0.0 0.24 12.0 0.0 1.6 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase Glyco_transf_4 PF13439.6 AIC15112.1 - 0.00016 21.7 0.8 0.00035 20.6 0.4 2.0 2 1 0 2 2 2 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 AIC15112.1 - 0.0024 18.3 0.0 0.0059 17.1 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Spt20 PF12090.8 AIC15112.1 - 0.044 13.4 0.1 1.8 8.1 0.1 2.5 1 1 1 2 2 2 0 Spt20 family Glyco_trans_4_2 PF13477.6 AIC15112.1 - 0.14 12.2 0.1 0.27 11.3 0.1 1.4 1 0 0 1 1 1 0 Glycosyl transferase 4-like Methyltransf_23 PF13489.6 AIC15113.1 - 2.7e-14 53.4 0.0 4.5e-14 52.6 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15113.1 - 1.9e-13 50.9 0.0 3.3e-13 50.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC15113.1 - 4.5e-11 42.8 0.0 6e-11 42.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC15113.1 - 5.2e-11 43.0 0.0 8.5e-11 42.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15113.1 - 2e-10 41.3 0.0 3.5e-10 40.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 AIC15113.1 - 8.8e-08 32.0 0.0 1.2e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) MTS PF05175.14 AIC15113.1 - 5.1e-05 22.9 0.1 0.00017 21.2 0.0 1.8 1 1 1 2 2 2 1 Methyltransferase small domain NNMT_PNMT_TEMT PF01234.17 AIC15113.1 - 0.00042 19.6 0.1 0.0017 17.6 0.0 1.8 1 1 1 2 2 2 1 NNMT/PNMT/TEMT family Ubie_methyltran PF01209.18 AIC15113.1 - 0.00063 19.1 0.1 0.00088 18.7 0.1 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Pox_MCEL PF03291.16 AIC15113.1 - 0.0013 17.9 0.2 0.002 17.3 0.2 1.3 1 0 0 1 1 1 1 mRNA capping enzyme Methyltransf_9 PF08003.11 AIC15113.1 - 0.0049 15.8 0.0 0.0066 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) Bin3 PF06859.12 AIC15113.1 - 0.071 13.8 0.0 0.14 12.8 0.0 1.5 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) Epimerase_2 PF02350.19 AIC15114.1 - 4e-97 325.2 0.0 4.5e-97 325.0 0.0 1.0 1 0 0 1 1 1 1 UDP-N-acetylglucosamine 2-epimerase Ribonucleas_3_2 PF11469.8 AIC15118.1 - 0.055 13.9 0.1 0.1 13.0 0.1 1.5 1 0 0 1 1 1 0 Ribonuclease III SnoaL_2 PF12680.7 AIC15119.1 - 3.7e-06 27.5 0.3 4.4e-06 27.3 0.3 1.3 1 1 0 1 1 1 1 SnoaL-like domain LppX_LprAFG PF07161.13 AIC15121.1 - 0.035 14.0 0.2 0.19 11.6 0.2 1.9 1 1 0 1 1 1 0 LppX_LprAFG lipoprotein PvlArgDC PF01862.16 AIC15123.1 - 1e-57 194.5 0.0 1.1e-57 194.3 0.0 1.0 1 0 0 1 1 1 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) IF3_N PF05198.16 AIC15123.1 - 0.06 13.6 0.0 0.11 12.7 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain DUF2207 PF09972.9 AIC15124.1 - 0.0039 16.0 1.7 0.0039 16.0 1.7 1.6 1 1 1 2 2 2 1 Predicted membrane protein (DUF2207) CSN7a_helixI PF18392.1 AIC15124.1 - 0.0093 15.9 0.2 0.024 14.5 0.2 1.7 1 0 0 1 1 1 1 COP9 signalosome complex subunit 7a helix I domain Baculo_11_kDa PF06143.11 AIC15124.1 - 0.011 15.2 1.3 0.038 13.6 1.3 2.0 1 0 0 1 1 1 0 Baculovirus 11 kDa family Pox_LP_H2 PF03356.15 AIC15124.1 - 0.013 15.4 1.9 0.021 14.7 1.9 1.2 1 0 0 1 1 1 0 Viral late protein H2 DUF485 PF04341.12 AIC15124.1 - 0.015 15.2 0.9 0.031 14.2 0.9 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF485 DUF2015 PF09435.10 AIC15124.1 - 0.017 15.0 0.5 6.8 6.6 0.0 2.5 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF2015) DUF4834 PF16118.5 AIC15124.1 - 0.022 15.7 2.0 0.049 14.6 2.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Orf78 PF06024.12 AIC15124.1 - 0.035 14.4 2.0 0.074 13.4 1.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) Spore_III_AB PF09548.10 AIC15124.1 - 0.053 13.6 0.0 0.087 12.9 0.0 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) Shisa PF13908.6 AIC15124.1 - 0.091 13.0 0.1 0.14 12.4 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Peptidase_S49_N PF08496.10 AIC15124.1 - 0.096 12.7 0.3 0.16 12.0 0.3 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Chordopox_A13L PF05961.11 AIC15124.1 - 0.1 12.9 0.9 0.21 11.9 0.5 1.8 2 0 0 2 2 1 0 Chordopoxvirus A13L protein EphA2_TM PF14575.6 AIC15124.1 - 0.11 13.4 0.1 0.11 13.4 0.1 1.7 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain ASFV_J13L PF05568.11 AIC15124.1 - 0.19 11.4 3.2 0.33 10.7 3.2 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein TMEM154 PF15102.6 AIC15124.1 - 0.7 9.8 5.7 1.6 8.6 5.7 1.8 1 1 0 1 1 1 0 TMEM154 protein family DUF5326 PF17260.2 AIC15124.1 - 4.7 7.4 10.8 0.31 11.2 4.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5326) HTH_45 PF14947.6 AIC15130.1 - 0.013 15.5 0.1 0.023 14.7 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Piwi PF02171.17 AIC15131.1 - 3e-12 46.4 0.0 5.5e-12 45.5 0.0 1.4 1 0 0 1 1 1 1 Piwi domain RdRP_4 PF02123.16 AIC15131.1 - 0.082 11.8 0.1 0.16 10.8 0.1 1.4 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase Tn7_Tnp_TnsA_C PF08721.11 AIC15132.1 - 0.11 13.1 0.0 0.15 12.7 0.0 1.3 1 1 0 1 1 1 0 TnsA endonuclease C terminal SMC_N PF02463.19 AIC15133.1 - 2.5e-10 40.2 17.7 4.2e-09 36.2 17.7 3.0 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AIC15133.1 - 6.1e-10 39.9 69.3 0.53 10.7 69.3 5.7 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AIC15133.1 - 7.3e-06 25.9 0.3 7.3e-06 25.9 0.3 3.9 3 1 0 3 3 3 1 AAA ATPase domain AAA_29 PF13555.6 AIC15133.1 - 0.0008 19.1 0.0 0.0019 17.9 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 AIC15133.1 - 0.0076 16.1 0.0 0.018 14.8 0.0 1.7 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 AIC15133.1 - 0.013 15.9 0.3 0.1 13.0 0.0 2.8 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Bac_DnaA PF00308.18 AIC15133.1 - 0.024 14.5 0.2 1.6 8.5 0.0 2.8 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_27 PF13514.6 AIC15133.1 - 0.033 13.8 0.0 0.033 13.8 0.0 4.2 4 0 0 4 4 4 0 AAA domain NACHT PF05729.12 AIC15133.1 - 0.045 13.7 6.5 2.1 8.2 0.3 3.8 5 0 0 5 5 5 0 NACHT domain AAA_22 PF13401.6 AIC15133.1 - 0.047 14.0 0.0 0.32 11.3 0.0 2.5 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AIC15133.1 - 0.049 14.1 0.1 0.049 14.1 0.1 4.2 3 2 1 4 4 4 0 ABC transporter AAA_16 PF13191.6 AIC15133.1 - 0.051 14.0 0.1 0.051 14.0 0.1 3.9 3 3 1 4 4 3 0 AAA ATPase domain AAA_33 PF13671.6 AIC15133.1 - 0.056 13.6 0.1 1.4 9.1 0.0 3.4 3 0 0 3 3 3 0 AAA domain DnaJ_CXXCXGXG PF00684.19 AIC15134.1 - 1.1e-06 28.9 0.2 1.6e-06 28.3 0.2 1.3 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AIC15134.1 - 0.0045 16.9 4.6 0.042 13.8 4.6 2.2 1 1 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein zf-TFIIB PF13453.6 AIC15134.1 - 0.081 12.3 3.7 0.37 10.1 3.7 2.1 1 1 0 1 1 1 0 Transcription factor zinc-finger zinc_ribbon_9 PF14369.6 AIC15134.1 - 0.093 13.0 5.4 3.2 8.1 0.6 2.3 1 1 1 2 2 2 0 zinc-ribbon Mut7-C PF01927.16 AIC15134.1 - 0.1 12.7 0.3 0.18 11.9 0.3 1.6 1 1 0 1 1 1 0 Mut7-C RNAse domain Zn-ribbon_8 PF09723.10 AIC15134.1 - 0.11 12.7 0.5 11 6.3 0.1 2.3 2 0 0 2 2 2 0 Zinc ribbon domain zf_Rg PF17915.1 AIC15134.1 - 0.11 11.9 0.4 4.4 6.8 0.1 2.3 2 0 0 2 2 2 0 Reverse gyrase zinc finger Zn_Tnp_IS1595 PF12760.7 AIC15134.1 - 0.17 11.9 0.4 17 5.5 0.0 2.4 2 0 0 2 2 2 0 Transposase zinc-ribbon domain CpXC PF14353.6 AIC15134.1 - 0.2 11.7 0.8 10 6.2 0.1 2.5 1 1 2 3 3 3 0 CpXC protein zf_CopZ PF18423.1 AIC15134.1 - 0.21 11.5 4.2 4 7.5 0.2 2.3 2 0 0 2 2 2 0 Zinc binding domain Rubredoxin_2 PF18073.1 AIC15134.1 - 0.62 9.8 3.6 4.2 7.2 0.1 2.2 2 0 0 2 2 2 0 Rubredoxin metal binding domain DUF5351 PF17302.2 AIC15134.1 - 1.4 9.2 5.4 19 5.5 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5351) Prim_Zn_Ribbon PF08273.12 AIC15134.1 - 2.7 8.4 5.2 7.3 7.0 1.2 2.6 3 0 0 3 3 3 0 Zinc-binding domain of primase-helicase HTH_45 PF14947.6 AIC15136.1 - 0.087 12.8 0.0 9.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn-helix MTES_1575 PF18741.1 AIC15138.1 - 2.7e-33 114.0 0.3 6.6e-33 112.8 0.3 1.7 1 0 0 1 1 1 1 REase_MTES_1575 AAA_12 PF13087.6 AIC15138.1 - 4.8e-21 75.3 0.0 1.3e-20 73.9 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 AIC15138.1 - 3.6e-14 53.2 0.2 1.2e-06 28.5 0.0 2.7 3 0 0 3 3 2 2 AAA domain DUF4011 PF13195.6 AIC15138.1 - 2.9e-10 40.3 0.0 1.6e-09 37.9 0.0 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF4011) zinc_ribbon_2 PF13240.6 AIC15138.1 - 9.3e-07 28.4 4.8 1.8e-06 27.4 4.8 1.5 1 0 0 1 1 1 1 zinc-ribbon domain AAA_19 PF13245.6 AIC15138.1 - 5.6e-06 26.7 0.0 3.8e-05 24.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AIC15138.1 - 6.6e-06 26.0 0.0 0.00075 19.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain DUF2075 PF09848.9 AIC15138.1 - 2e-05 24.0 0.5 0.0088 15.3 0.0 3.5 4 0 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) DZR PF12773.7 AIC15138.1 - 0.00012 22.1 1.5 0.00023 21.1 1.5 1.4 1 0 0 1 1 1 1 Double zinc ribbon DUF559 PF04480.12 AIC15138.1 - 0.00046 20.0 0.0 0.0014 18.4 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF559) Viral_helicase1 PF01443.18 AIC15138.1 - 0.0011 18.8 0.1 0.27 10.9 0.1 3.2 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 AIC15138.1 - 0.002 17.6 0.0 0.063 12.7 0.0 2.7 2 0 0 2 2 2 1 PhoH-like protein AAA_16 PF13191.6 AIC15138.1 - 0.0028 18.0 0.0 0.023 15.1 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain zf-ribbon_3 PF13248.6 AIC15138.1 - 0.0034 16.7 4.5 0.0069 15.7 4.5 1.5 1 0 0 1 1 1 1 zinc-ribbon domain IstB_IS21 PF01695.17 AIC15138.1 - 0.0083 15.9 0.0 0.024 14.4 0.0 1.7 1 0 0 1 1 1 1 IstB-like ATP binding protein zinc_ribbon_15 PF17032.5 AIC15138.1 - 0.027 15.2 2.5 0.055 14.2 2.5 1.5 1 0 0 1 1 1 0 zinc-ribbon family ResIII PF04851.15 AIC15138.1 - 0.03 14.3 0.0 0.23 11.4 0.0 2.3 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit UvrD_C_2 PF13538.6 AIC15138.1 - 0.041 13.7 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain TrwB_AAD_bind PF10412.9 AIC15138.1 - 0.046 12.6 0.0 0.09 11.7 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain DUF3638 PF12340.8 AIC15138.1 - 0.055 12.8 1.1 0.092 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3638) DEAD PF00270.29 AIC15138.1 - 0.076 12.8 0.3 0.51 10.1 0.0 2.5 2 1 0 2 2 2 0 DEAD/DEAH box helicase DUF35_N PF12172.8 AIC15138.1 - 0.083 12.8 1.7 0.15 11.9 1.7 1.4 1 0 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) UvrD-helicase PF00580.21 AIC15138.1 - 0.086 12.3 0.0 0.77 9.2 0.0 2.4 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain DUF573 PF04504.14 AIC15138.1 - 0.088 13.5 0.3 0.53 11.0 0.1 2.5 2 0 0 2 2 1 0 Protein of unknown function, DUF573 Herpes_ori_bp PF02399.15 AIC15138.1 - 0.089 10.8 0.0 0.14 10.2 0.0 1.2 1 0 0 1 1 1 0 Origin of replication binding protein AAA_22 PF13401.6 AIC15138.1 - 0.092 13.0 0.2 0.59 10.4 0.0 2.5 2 0 0 2 2 1 0 AAA domain Adeno_IVa2 PF02456.15 AIC15138.1 - 0.12 11.2 0.0 0.22 10.3 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein MeaB PF03308.16 AIC15138.1 - 0.12 11.4 0.1 0.36 9.8 0.0 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_5 PF07728.14 AIC15138.1 - 0.12 12.4 0.2 2.8 7.9 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Helicase_RecD PF05127.14 AIC15138.1 - 0.16 11.8 0.0 0.39 10.5 0.0 1.7 1 0 0 1 1 1 0 Helicase UPF0547 PF10571.9 AIC15138.1 - 0.31 11.2 2.3 0.65 10.1 2.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 UvrD-helicase PF00580.21 AIC15139.1 - 8.3e-64 216.1 0.1 8.3e-64 216.1 0.1 2.5 2 1 0 2 2 2 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 AIC15139.1 - 8.9e-45 153.6 0.5 8.9e-45 153.6 0.5 2.2 2 1 0 2 2 2 1 UvrD-like helicase C-terminal domain PDDEXK_1 PF12705.7 AIC15139.1 - 1e-37 130.5 0.1 2.4e-37 129.2 0.1 1.7 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily AAA_19 PF13245.6 AIC15139.1 - 1.5e-32 113.0 0.0 3.1e-32 111.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain UvrD_C_2 PF13538.6 AIC15139.1 - 3.4e-13 49.2 0.3 1.1e-05 25.1 0.1 2.5 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain AAA_30 PF13604.6 AIC15139.1 - 7.6e-08 32.3 0.0 2.5e-05 24.1 0.0 2.4 2 0 0 2 2 2 2 AAA domain Viral_helicase1 PF01443.18 AIC15139.1 - 5e-06 26.4 1.1 0.22 11.3 0.0 4.2 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase Cas_Cas4 PF01930.17 AIC15139.1 - 8.5e-06 26.0 1.3 3.6e-05 23.9 0.0 2.8 2 1 1 3 3 2 1 Domain of unknown function DUF83 AAA_11 PF13086.6 AIC15139.1 - 4.7e-05 23.3 6.4 4.8e-05 23.3 1.7 3.0 2 2 0 2 2 2 1 AAA domain AAA_12 PF13087.6 AIC15139.1 - 5.2e-05 23.0 0.1 0.0012 18.5 0.0 3.1 3 0 0 3 3 3 1 AAA domain Adaptin_binding PF10199.9 AIC15139.1 - 0.021 15.4 1.0 0.063 13.9 1.0 1.8 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 AAA_16 PF13191.6 AIC15139.1 - 0.08 13.3 0.1 2.1 8.7 0.0 2.9 2 0 0 2 2 2 0 AAA ATPase domain N6_Mtase PF02384.16 AIC15140.1 - 3.6e-05 23.2 0.5 0.18 11.0 0.0 4.9 4 1 0 4 4 4 2 N-6 DNA Methylase Eco57I PF07669.11 AIC15140.1 - 4e-05 24.1 0.1 0.00068 20.1 0.0 2.9 2 1 0 2 2 2 1 Eco57I restriction-modification methylase Helicase_C PF00271.31 AIC15141.1 - 1.6e-19 70.2 0.1 8.3e-19 68.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain PLDc_2 PF13091.6 AIC15141.1 - 2.6e-14 53.2 1.2 1.5e-13 50.8 0.3 2.5 2 0 0 2 2 2 1 PLD-like domain ResIII PF04851.15 AIC15141.1 - 1e-11 45.2 0.6 2.4e-05 24.4 0.0 3.6 2 1 1 3 3 3 2 Type III restriction enzyme, res subunit SNF2_N PF00176.23 AIC15141.1 - 3e-11 42.6 0.0 2.3e-07 29.9 0.0 3.1 2 1 0 3 3 3 2 SNF2 family N-terminal domain DEAD PF00270.29 AIC15141.1 - 5e-06 26.4 0.1 0.097 12.4 0.0 3.1 1 1 1 2 2 2 2 DEAD/DEAH box helicase Flavi_DEAD PF07652.14 AIC15141.1 - 0.00017 21.6 0.2 0.013 15.5 0.2 2.7 1 1 0 1 1 1 1 Flavivirus DEAD domain PLDc PF00614.22 AIC15141.1 - 0.00037 20.6 0.1 0.0056 16.8 0.1 2.5 2 0 0 2 2 2 1 Phospholipase D Active site motif NMT PF01233.19 AIC15141.1 - 0.035 14.0 0.3 0.18 11.7 0.1 2.3 2 0 0 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain CobA_CobO_BtuR PF02572.15 AIC15141.1 - 0.09 13.0 0.2 17 5.7 0.0 3.1 2 0 0 2 2 2 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP HD PF01966.22 AIC15142.1 - 4.1e-10 39.9 0.5 1.3e-09 38.3 0.5 2.0 1 0 0 1 1 1 1 HD domain Tma16 PF11176.8 AIC15142.1 - 0.12 12.2 0.9 0.47 10.3 0.2 2.3 3 0 0 3 3 3 0 Translation machinery-associated protein 16 DUF4972 PF16342.5 AIC15143.1 - 0.089 12.5 0.0 3 7.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) Radical_SAM PF04055.21 AIC15144.1 - 0.00056 20.3 0.1 0.0029 18.0 0.1 2.2 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 AIC15144.1 - 0.071 13.4 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain eIF-5a PF01287.20 AIC15144.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold DUF1848 PF08902.11 AIC15144.1 - 0.78 9.4 2.4 4.4 7.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) DUF5131 PF07505.11 AIC15145.1 - 4e-55 186.9 0.0 4.6e-55 186.7 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF5131) Cdc6_C PF09079.11 AIC15146.1 - 1.3e-08 34.7 0.2 5.2e-08 32.8 0.1 1.9 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain AAA_22 PF13401.6 AIC15146.1 - 1.5e-08 35.0 0.2 6.3e-08 33.0 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AIC15146.1 - 1.7e-05 25.3 0.1 0.002 18.6 0.1 2.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 AIC15146.1 - 0.00013 21.8 0.0 0.00021 21.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 AIC15146.1 - 0.0032 16.9 0.0 0.0057 16.1 0.0 1.4 1 0 0 1 1 1 1 Bacterial TniB protein AAA PF00004.29 AIC15146.1 - 0.0032 17.9 0.1 0.0099 16.3 0.1 1.9 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 AIC15146.1 - 0.036 14.0 1.9 0.082 12.8 0.2 2.3 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea JHD PF17811.1 AIC15146.1 - 0.084 13.4 0.0 0.84 10.2 0.0 2.3 2 0 0 2 2 2 0 Jumonji helical domain HTH_20 PF12840.7 AIC15147.1 - 2.3e-06 27.6 0.0 3.6e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain Rrf2 PF02082.20 AIC15147.1 - 3.1e-05 24.2 0.1 4.2e-05 23.8 0.1 1.2 1 0 0 1 1 1 1 Transcriptional regulator HTH_5 PF01022.20 AIC15147.1 - 0.0023 17.7 1.6 0.0069 16.2 1.6 1.8 1 1 0 1 1 1 1 Bacterial regulatory protein, arsR family RepL PF05732.11 AIC15147.1 - 0.0048 16.3 0.0 0.005 16.3 0.0 1.2 1 0 0 1 1 1 1 Firmicute plasmid replication protein (RepL) DUF4423 PF14394.6 AIC15147.1 - 0.0071 16.1 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) DUF1495 PF07381.11 AIC15147.1 - 0.014 15.3 0.2 0.083 12.7 0.2 1.9 1 1 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) HTH_34 PF13601.6 AIC15147.1 - 0.016 15.4 0.1 0.022 14.9 0.1 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_45 PF14947.6 AIC15147.1 - 0.02 14.9 0.0 0.025 14.6 0.0 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix MarR_2 PF12802.7 AIC15147.1 - 0.034 14.0 0.0 0.052 13.4 0.0 1.2 1 0 0 1 1 1 0 MarR family DUF2513 PF10711.9 AIC15147.1 - 0.045 14.1 0.0 0.058 13.7 0.0 1.2 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) TrmB PF01978.19 AIC15147.1 - 0.065 13.1 0.0 0.084 12.8 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Cullin PF00888.22 AIC15147.1 - 0.18 10.4 0.0 0.18 10.4 0.0 1.2 1 0 0 1 1 1 0 Cullin family HTH_IclR PF09339.10 AIC15148.1 - 1.5e-06 27.9 0.0 3.1e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.7 AIC15148.1 - 5.2e-05 23.0 0.0 7.9e-05 22.5 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_28 PF13518.6 AIC15148.1 - 0.00015 21.8 0.0 0.00027 21.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 AIC15148.1 - 0.00019 21.3 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB SpoIIID PF12116.8 AIC15148.1 - 0.00024 21.1 0.0 0.00044 20.3 0.0 1.4 1 0 0 1 1 1 1 Stage III sporulation protein D HTH_10 PF04967.12 AIC15148.1 - 0.0031 17.3 0.1 0.0053 16.5 0.1 1.3 1 0 0 1 1 1 1 HTH DNA binding domain Fe_dep_repress PF01325.19 AIC15148.1 - 0.0038 17.4 0.0 0.008 16.4 0.0 1.5 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_24 PF13412.6 AIC15148.1 - 0.0046 16.5 0.0 0.0082 15.7 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_23 PF13384.6 AIC15148.1 - 0.0055 16.5 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 Homeodomain-like domain GntR PF00392.21 AIC15148.1 - 0.014 15.1 0.1 0.03 14.0 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 AIC15148.1 - 0.015 15.2 0.0 0.037 14.0 0.0 1.7 1 1 0 1 1 1 0 HTH domain HTH_20 PF12840.7 AIC15148.1 - 0.017 15.2 0.1 0.03 14.4 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain DUF4423 PF14394.6 AIC15148.1 - 0.019 14.6 0.1 0.047 13.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4423) EAP30 PF04157.16 AIC15148.1 - 0.02 14.2 0.1 0.024 13.9 0.1 1.1 1 0 0 1 1 1 0 EAP30/Vps36 family FaeA PF04703.12 AIC15148.1 - 0.021 15.2 0.0 0.035 14.5 0.0 1.4 1 0 0 1 1 1 0 FaeA-like protein MarR PF01047.22 AIC15148.1 - 0.03 14.2 0.0 0.081 12.9 0.0 1.7 2 0 0 2 2 2 0 MarR family LexA_DNA_bind PF01726.16 AIC15148.1 - 0.058 13.2 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 LexA DNA binding domain HTH_5 PF01022.20 AIC15148.1 - 0.076 12.9 0.0 0.2 11.6 0.0 1.7 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family CobN-Mg_chel PF02514.16 AIC15148.1 - 0.15 9.7 0.1 0.17 9.6 0.1 1.0 1 0 0 1 1 1 0 CobN/Magnesium Chelatase TFIIB PF00382.19 AIC15150.1 - 0.15 12.1 1.7 8.8 6.5 0.4 2.7 2 1 0 2 2 2 0 Transcription factor TFIIB repeat ParBc PF02195.18 AIC15151.1 - 3.3e-13 49.7 0.0 6e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 ParB-like nuclease domain zinc_ribbon_4 PF13717.6 AIC15151.1 - 0.27 11.2 1.2 1.1e+02 2.9 0.0 3.4 3 0 0 3 3 3 0 zinc-ribbon domain VirB8 PF04335.13 AIC15152.1 - 0.014 15.2 1.4 0.014 15.2 1.4 1.6 1 1 1 2 2 2 0 VirB8 protein CBM_4_9 PF02018.17 AIC15152.1 - 0.019 15.3 2.0 0.77 10.0 0.1 2.1 1 1 0 2 2 2 0 Carbohydrate binding domain DUF3426 PF11906.8 AIC15152.1 - 0.092 12.9 0.1 0.13 12.5 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3426) Pilin_N PF07790.11 AIC15152.1 - 1.8 9.5 7.2 1.7 9.6 5.6 1.7 1 1 1 2 2 2 0 Archaeal Type IV pilin, N-terminal Pilin_N PF07790.11 AIC15153.1 - 0.0079 17.1 1.1 0.018 16.0 1.0 1.7 1 1 0 1 1 1 1 Archaeal Type IV pilin, N-terminal RskA PF10099.9 AIC15153.1 - 0.064 13.6 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA I-set PF07679.16 AIC15154.1 - 4e-05 23.6 3.0 6.5 6.9 0.0 7.8 9 0 0 9 9 9 1 Immunoglobulin I-set domain DUF499 PF04465.12 AIC15154.1 - 7.9e-05 20.6 0.0 0.33 8.7 0.0 4.3 4 1 3 7 7 7 2 Protein of unknown function (DUF499) FixG_C PF11614.8 AIC15154.1 - 0.00021 21.5 11.4 7.2 6.9 0.1 7.7 6 2 1 8 8 8 1 IG-like fold at C-terminal of FixG, putative oxidoreductase Y_Y_Y PF07495.13 AIC15154.1 - 0.0013 18.6 4.2 0.89 9.6 0.0 6.8 8 1 1 9 9 9 1 Y_Y_Y domain fn3_6 PF17766.1 AIC15154.1 - 0.0034 17.5 28.9 0.97 9.7 0.0 10.5 8 2 4 12 12 12 2 Fibronectin type-III domain DUF3324 PF11797.8 AIC15154.1 - 0.0041 17.1 12.3 10 6.1 0.0 7.6 10 0 0 10 10 10 1 Protein of unknown function C-terminal (DUF3324) DUF4625 PF15418.6 AIC15154.1 - 0.0042 17.3 0.0 27 5.0 0.0 5.4 6 0 0 6 6 6 0 Domain of unknown function (DUF4625) MG2 PF01835.19 AIC15154.1 - 0.053 14.0 20.2 14 6.2 0.1 8.8 8 2 1 10 10 10 0 MG2 domain Cadherin PF00028.17 AIC15154.1 - 0.96 9.9 15.2 70 4.0 0.3 7.4 8 0 0 8 8 7 0 Cadherin domain E1_DerP2_DerF2 PF02221.15 AIC15154.1 - 0.98 9.9 5.0 1.6e+02 2.7 0.1 5.7 4 2 1 5 5 5 0 ML domain MG4 PF17789.1 AIC15154.1 - 9.1 6.5 12.4 7.9 6.7 0.3 5.6 4 1 0 4 4 4 0 Macroglobulin domain MG4 HATPase_c_3 PF13589.6 AIC15157.1 - 3.5e-06 26.9 0.0 8e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase T2SSE PF00437.20 AIC15158.1 - 2.6e-40 138.2 0.0 4.1e-40 137.6 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein ABC_tran PF00005.27 AIC15158.1 - 0.0021 18.6 0.0 0.0097 16.4 0.0 2.1 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 AIC15158.1 - 0.0051 16.5 0.6 0.012 15.3 0.2 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 AIC15158.1 - 0.0079 15.6 0.2 0.081 12.3 0.1 2.4 2 0 0 2 2 2 1 FtsK/SpoIIIE family AAA_18 PF13238.6 AIC15158.1 - 0.011 16.3 1.1 0.054 14.0 0.2 2.4 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AIC15158.1 - 0.052 13.8 0.0 0.14 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 AIC15158.1 - 0.053 13.9 0.0 0.2 12.0 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain SRP54 PF00448.22 AIC15158.1 - 0.062 12.9 0.3 0.15 11.7 0.1 1.7 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_28 PF13521.6 AIC15158.1 - 0.062 13.5 0.5 0.2 11.9 0.0 2.1 2 1 0 2 2 2 0 AAA domain TrwB_AAD_bind PF10412.9 AIC15158.1 - 0.081 11.8 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_30 PF13604.6 AIC15158.1 - 0.16 11.7 0.1 0.6 9.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain T2SSF PF00482.23 AIC15161.1 - 3.4e-07 30.3 0.0 3.4e-07 30.3 0.0 4.0 4 0 0 4 4 4 2 Type II secretion system (T2SS), protein F DUF2647 PF10839.8 AIC15161.1 - 0.056 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2647) UPF0182 PF03699.13 AIC15162.1 - 9.5 4.2 7.2 13 3.7 7.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) GRAM PF02893.20 AIC15163.1 - 0.00013 21.9 0.0 0.00022 21.1 0.0 1.4 1 0 0 1 1 1 1 GRAM domain Vps36_ESCRT-II PF11605.8 AIC15163.1 - 0.0028 17.8 0.1 0.0074 16.4 0.1 1.8 1 0 0 1 1 1 1 Vacuolar protein sorting protein 36 Vps36 PIN PF01850.21 AIC15164.1 - 9.5e-17 61.6 0.1 1.1e-16 61.5 0.1 1.0 1 0 0 1 1 1 1 PIN domain PIN_3 PF13470.6 AIC15164.1 - 0.032 15.0 0.0 0.04 14.7 0.0 1.2 1 0 0 1 1 1 0 PIN domain MazE_antitoxin PF04014.18 AIC15165.1 - 0.00093 19.1 0.0 0.0019 18.1 0.0 1.7 1 1 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin PrlF_antitoxin PF15937.5 AIC15165.1 - 0.016 15.6 0.0 0.022 15.2 0.0 1.3 1 0 0 1 1 1 0 prlF antitoxin for toxin YhaV_toxin DUF123 PF01986.16 AIC15166.1 - 1.1e-16 61.1 0.1 1.3e-16 60.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF123 GIY-YIG PF01541.24 AIC15166.1 - 0.0043 17.3 0.0 0.0048 17.2 0.0 1.3 1 1 0 1 1 1 1 GIY-YIG catalytic domain PrgI PF12666.7 AIC15167.1 - 0.018 15.7 1.0 0.029 15.1 1.0 1.3 1 0 0 1 1 1 0 PrgI family protein DUF2635 PF10948.8 AIC15167.1 - 0.065 13.0 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2635) PEGA PF08308.11 AIC15167.1 - 0.099 12.5 0.1 0.4 10.6 0.1 1.9 1 1 0 1 1 1 0 PEGA domain AAA_10 PF12846.7 AIC15168.1 - 1.2e-13 50.8 0.0 5e-07 29.0 0.0 2.3 2 0 0 2 2 2 2 AAA-like domain DUF87 PF01935.17 AIC15168.1 - 8e-10 39.2 0.0 1.9e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 Helicase HerA, central domain TrwB_AAD_bind PF10412.9 AIC15168.1 - 0.0071 15.3 0.0 2.3 7.1 0.0 2.3 2 0 0 2 2 2 2 Type IV secretion-system coupling protein DNA-binding domain AAA_22 PF13401.6 AIC15168.1 - 0.033 14.5 0.0 2.4 8.4 0.0 3.4 3 1 0 3 3 3 0 AAA domain TraG-D_C PF12696.7 AIC15168.1 - 0.13 12.3 0.0 0.25 11.3 0.0 1.5 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG DUF418 PF04235.12 AIC15169.1 - 0.034 14.1 1.2 0.046 13.6 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF418) GtrA PF04138.14 AIC15169.1 - 0.039 14.2 0.1 0.13 12.6 0.1 1.7 1 1 1 2 2 2 0 GtrA-like protein L6_membrane PF05805.12 AIC15169.1 - 0.1 12.1 0.4 0.13 11.8 0.4 1.2 1 0 0 1 1 1 0 L6 membrane protein Yip1 PF04893.17 AIC15169.1 - 2 8.1 10.2 19 4.9 10.2 1.9 1 1 0 1 1 1 0 Yip1 domain AAA_22 PF13401.6 AIC15172.1 - 1.3e-05 25.4 0.0 0.00067 19.9 0.0 3.1 3 0 0 3 3 3 1 AAA domain TrwB_AAD_bind PF10412.9 AIC15172.1 - 1.4e-05 24.2 0.0 3.7e-05 22.8 0.0 1.7 1 1 0 1 1 1 1 Type IV secretion-system coupling protein DNA-binding domain MarR_2 PF12802.7 AIC15172.1 - 2.6e-05 24.0 0.2 0.0013 18.6 0.0 2.5 2 0 0 2 2 2 1 MarR family FtsK_SpoIIIE PF01580.18 AIC15172.1 - 0.00091 18.7 0.0 0.002 17.5 0.0 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_14 PF13173.6 AIC15172.1 - 0.0018 18.3 0.1 0.033 14.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain HTH_45 PF14947.6 AIC15172.1 - 0.0023 17.9 0.0 0.048 13.7 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn-helix HTH_24 PF13412.6 AIC15172.1 - 0.0068 15.9 2.2 0.014 14.9 0.0 2.7 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding AAA_10 PF12846.7 AIC15172.1 - 0.014 14.3 0.0 0.027 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA-like domain HTH_27 PF13463.6 AIC15172.1 - 0.025 15.1 0.0 6.8 7.3 0.0 3.1 2 0 0 2 2 2 0 Winged helix DNA-binding domain TraG-D_C PF12696.7 AIC15172.1 - 0.03 14.3 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 TraM recognition site of TraD and TraG DUF87 PF01935.17 AIC15172.1 - 0.032 14.3 0.3 0.3 11.1 0.1 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain ATPase_2 PF01637.18 AIC15172.1 - 0.061 13.2 2.3 0.3 10.9 0.0 2.8 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea HTH_IclR PF09339.10 AIC15172.1 - 0.061 13.1 0.3 0.96 9.3 0.0 2.9 3 0 0 3 3 3 0 IclR helix-turn-helix domain AAA_23 PF13476.6 AIC15172.1 - 0.087 13.3 0.2 0.25 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain Suppressor_P21 PF11479.8 AIC15172.1 - 0.1 12.8 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 RNA silencing suppressor P21 C-terminal domain TcfC PF16967.5 AIC15175.1 - 0.0054 16.2 0.3 0.014 14.8 0.0 1.8 2 0 0 2 2 2 1 E-set like domain SnoaL PF07366.12 AIC15175.1 - 0.017 14.9 0.0 0.024 14.4 0.0 1.3 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase NapB PF03892.14 AIC15175.1 - 0.032 14.3 1.8 0.034 14.2 1.8 1.2 1 1 0 1 1 1 0 Nitrate reductase cytochrome c-type subunit (NapB) Vps39_2 PF10367.9 AIC15177.1 - 0.14 12.7 0.3 0.19 12.2 0.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 TRAM PF01938.20 AIC15184.1 - 1.8e-14 53.4 1.8 2.1e-14 53.2 1.8 1.1 1 0 0 1 1 1 1 TRAM domain GAS PF13851.6 AIC15186.1 - 0.00093 18.6 0.4 0.096 12.0 0.0 2.1 2 0 0 2 2 2 2 Growth-arrest specific micro-tubule binding SKA2 PF16740.5 AIC15186.1 - 0.029 14.1 1.0 1.4 8.7 0.1 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Takusan PF04822.13 AIC15186.1 - 0.052 13.4 1.6 3.2 7.7 0.4 2.2 2 0 0 2 2 2 0 Takusan FlaC_arch PF05377.11 AIC15186.1 - 0.095 13.1 0.8 7.6 7.0 0.0 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) K-box PF01486.17 AIC15186.1 - 0.11 12.7 2.9 1 9.6 0.1 2.2 2 0 0 2 2 2 0 K-box region BLOC1_2 PF10046.9 AIC15186.1 - 0.12 12.7 3.3 1.3 9.4 0.2 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Snapin_Pallidin PF14712.6 AIC15186.1 - 0.13 12.7 3.5 2 8.9 0.4 2.1 2 0 0 2 2 2 0 Snapin/Pallidin Peptidase_A24 PF01478.18 AIC15187.1 - 3.4e-10 40.3 9.5 3.4e-10 40.3 9.5 2.1 2 0 0 2 2 2 1 Type IV leader peptidase family Arc_PepC_II PF06847.11 AIC15187.1 - 1.4e-07 31.9 0.0 2.7e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 Archaeal Peptidase A24 C-terminus Type II CbiN PF02553.15 AIC15187.1 - 0.0059 16.6 0.3 0.031 14.3 0.2 2.2 1 1 1 2 2 2 1 Cobalt transport protein component CbiN TcA_TcB_BD PF18276.1 AIC15188.1 - 0.0084 15.2 0.2 0.0084 15.2 0.2 1.1 1 0 0 1 1 1 1 Tc toxin complex TcA C-terminal TcB-binding domain ParD_antitoxin PF03693.14 AIC15188.1 - 0.02 15.3 0.0 0.027 14.9 0.0 1.1 1 0 0 1 1 1 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH zf_C2H2_6 PF18450.1 AIC15190.1 - 0.056 13.2 1.3 0.11 12.2 1.3 1.4 1 0 0 1 1 1 0 Zinc Finger domain Hrs_helical PF12210.8 AIC15191.1 - 0.0017 18.9 1.3 0.0019 18.7 1.3 1.0 1 0 0 1 1 1 1 Hepatocyte growth factor-regulated tyrosine kinase substrate TcdB_N PF12918.7 AIC15191.1 - 0.02 15.1 1.1 0.043 14.1 0.2 1.7 1 1 1 2 2 2 0 TcdB toxin N-terminal helical domain Phage_integrase PF00589.22 AIC15192.1 - 3.9e-15 56.1 0.0 7.3e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 Phage integrase family zf-ribbon_3 PF13248.6 AIC15192.1 - 0.0015 17.9 2.4 0.0029 17.0 2.4 1.4 1 0 0 1 1 1 1 zinc-ribbon domain Ribosomal_L37e PF01907.19 AIC15192.1 - 0.016 15.3 0.6 0.041 14.0 0.6 1.6 1 0 0 1 1 1 0 Ribosomal protein L37e DZR PF12773.7 AIC15192.1 - 0.031 14.3 2.1 0.049 13.7 0.5 1.9 2 0 0 2 2 2 0 Double zinc ribbon tRNA-synt_1g PF09334.11 AIC15192.1 - 0.044 12.5 0.2 0.078 11.7 0.2 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (M) zinc_ribbon_2 PF13240.6 AIC15192.1 - 0.062 13.0 6.3 0.16 11.7 6.3 1.8 1 1 0 1 1 1 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIC15192.1 - 0.11 12.0 1.8 0.48 10.0 1.8 2.0 1 1 0 1 1 1 0 TFIIB zinc-binding YhfH PF14149.6 AIC15192.1 - 0.19 11.8 9.4 0.2 11.7 0.3 2.8 2 1 1 3 3 3 0 YhfH-like protein UPF0547 PF10571.9 AIC15192.1 - 0.87 9.7 5.8 2.7 8.2 5.8 1.8 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 DUF1059 PF06348.11 AIC15193.1 - 1.1e-19 70.4 1.1 1.4e-19 70.0 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1059) DUF1376 PF07120.11 AIC15196.1 - 0.028 14.7 0.0 0.045 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1376) GST_C PF00043.25 AIC15200.1 - 0.0018 18.5 0.0 0.0053 16.9 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 AIC15200.1 - 0.0055 16.7 0.6 0.017 15.2 0.1 2.0 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain PAC2 PF09754.9 AIC15201.1 - 1.4e-40 139.6 0.0 1.7e-40 139.3 0.0 1.0 1 0 0 1 1 1 1 PAC2 family tRNA_anti-codon PF01336.25 AIC15202.1 - 5.8e-08 32.6 0.2 7e-08 32.4 0.2 1.1 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 AIC15202.1 - 0.0018 18.1 0.3 0.0022 17.9 0.3 1.1 1 0 0 1 1 1 1 Replication protein A OB domain TackOD1 PF18551.1 AIC15203.1 - 0.017 14.8 0.6 0.017 14.8 0.6 1.0 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 A2L_zn_ribbon PF08792.10 AIC15203.1 - 0.023 14.4 3.7 0.35 10.6 0.2 2.1 2 0 0 2 2 2 0 A2L zinc ribbon domain Paired_CXXCH_1 PF09699.10 AIC15203.1 - 0.031 14.0 2.0 0.099 12.4 0.2 2.0 2 0 0 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) zf-dskA_traR PF01258.17 AIC15203.1 - 0.044 13.7 1.3 4 7.5 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger zf-piccolo PF05715.13 AIC15203.1 - 0.23 11.7 3.7 2.1 8.6 3.7 2.0 1 1 0 1 1 1 0 Piccolo Zn-finger zinc_ribbon_13 PF09855.9 AIC15203.1 - 0.31 11.2 4.0 1 9.5 0.3 2.1 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DUF192 PF02643.15 AIC15204.1 - 7.7e-19 67.7 0.0 9.7e-19 67.3 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 Arch_flagellin PF01917.16 AIC15205.1 - 2.8e-23 82.9 7.7 3.7e-23 82.5 7.7 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin Claudin_2 PF13903.6 AIC15205.1 - 0.063 13.0 0.2 0.11 12.3 0.2 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction TrmB PF01978.19 AIC15206.1 - 6.8e-12 45.1 0.0 1.6e-11 43.9 0.0 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Regulator_TrmB PF11495.8 AIC15206.1 - 9e-11 41.4 0.1 8.9e-05 21.8 0.1 2.3 2 1 0 2 2 2 2 Archaeal transcriptional regulator TrmB PLDc_2 PF13091.6 AIC15206.1 - 0.0026 17.6 0.0 0.061 13.2 0.0 2.7 2 1 0 2 2 2 1 PLD-like domain MarR PF01047.22 AIC15206.1 - 0.0026 17.6 0.0 0.0062 16.5 0.0 1.6 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 AIC15206.1 - 0.018 14.9 0.3 0.064 13.2 0.1 2.0 2 0 0 2 2 2 0 MarR family HTH_Crp_2 PF13545.6 AIC15206.1 - 0.057 13.4 0.1 0.76 9.8 0.0 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain HTH_IclR PF09339.10 AIC15206.1 - 0.058 13.2 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain MCPsignal PF00015.21 AIC15207.1 - 6.1e-42 143.3 56.4 2.5e-41 141.3 23.8 3.9 1 1 3 4 4 4 4 Methyl-accepting chemotaxis protein (MCP) signalling domain HAMP PF00672.25 AIC15207.1 - 3.3e-17 62.6 1.1 1.1e-13 51.4 0.0 4.7 4 0 0 4 4 4 1 HAMP domain dCache_1 PF02743.18 AIC15207.1 - 7.1e-11 42.4 0.1 7.1e-11 42.4 0.1 4.1 3 2 1 4 4 4 1 Cache domain Isochorismatase PF00857.20 AIC15207.1 - 0.0062 16.7 2.0 4.2 7.5 0.0 3.3 3 0 0 3 3 3 2 Isochorismatase family RPW8 PF05659.11 AIC15207.1 - 0.62 9.7 6.0 0.31 10.7 0.5 2.8 2 1 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Syntaxin_2 PF14523.6 AIC15207.1 - 2.8 8.3 23.3 2.3 8.6 2.9 5.1 3 1 3 6 6 6 0 Syntaxin-like protein Laminin_II PF06009.12 AIC15207.1 - 5.6 7.0 44.6 0.23 11.5 3.3 5.9 3 2 3 6 6 6 0 Laminin Domain II DUF948 PF06103.11 AIC15207.1 - 7.5 6.9 37.9 4.7 7.5 3.9 5.3 3 2 2 5 5 5 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.21 AIC15210.1 - 9.8e-14 51.5 2.2 1.7e-13 50.7 2.2 1.4 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain dCache_1 PF02743.18 AIC15210.1 - 4.4e-11 43.0 0.0 7.5e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Cache domain sCache_like PF16736.5 AIC15210.1 - 0.00041 20.4 1.8 0.013 15.6 0.0 3.1 3 1 0 3 3 3 1 Single Cache-like CheW PF01584.19 AIC15211.1 - 6.3e-31 106.8 1.8 7.4e-31 106.6 1.8 1.0 1 0 0 1 1 1 1 CheW-like domain Response_reg PF00072.24 AIC15212.1 - 6.3e-31 106.8 1.2 7.1e-31 106.7 1.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain DUF3798 PF12683.7 AIC15212.1 - 0.0048 16.4 0.5 0.0064 16.0 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3798) CheB_methylest PF01339.17 AIC15213.1 - 5.8e-56 188.9 0.1 2.9e-55 186.6 0.2 1.9 2 0 0 2 2 2 1 CheB methylesterase Response_reg PF00072.24 AIC15213.1 - 5.1e-20 71.7 0.1 1.1e-19 70.7 0.1 1.6 1 0 0 1 1 1 1 Response regulator receiver domain DUF3798 PF12683.7 AIC15213.1 - 0.017 14.5 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) CheW PF01584.19 AIC15214.1 - 3.4e-20 72.1 0.3 6.1e-20 71.3 0.3 1.4 1 0 0 1 1 1 1 CheW-like domain Hpt PF01627.23 AIC15214.1 - 4.2e-19 68.6 0.4 1.4e-18 66.9 0.4 1.9 1 0 0 1 1 1 1 Hpt domain HATPase_c PF02518.26 AIC15214.1 - 3.9e-18 66.0 0.2 1.2e-17 64.4 0.2 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase H-kinase_dim PF02895.14 AIC15214.1 - 3.3e-11 43.4 1.0 3.3e-11 43.4 1.0 2.8 3 0 0 3 3 3 1 Signal transducing histidine kinase, homodimeric domain Snf7 PF03357.21 AIC15214.1 - 0.002 17.7 3.3 0.002 17.7 3.3 2.3 3 1 0 3 3 2 1 Snf7 HATPase_c_3 PF13589.6 AIC15214.1 - 0.0037 17.1 1.1 0.02 14.7 1.1 2.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase SUIM_assoc PF16619.5 AIC15214.1 - 0.02 14.9 6.6 0.85 9.7 1.0 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 LPD11 PF18824.1 AIC15214.1 - 0.11 12.6 2.5 27 4.9 0.0 3.3 3 0 0 3 3 3 0 Large polyvalent protein-associated domain 11 HATPase_c_2 PF13581.6 AIC15214.1 - 0.14 12.1 0.3 0.38 10.7 0.0 1.9 2 0 0 2 2 2 0 Histidine kinase-like ATPase domain HeLo PF14479.6 AIC15214.1 - 0.27 11.0 4.8 0.17 11.7 2.6 1.8 2 0 0 2 2 2 0 Prion-inhibition and propagation Med3 PF11593.8 AIC15214.1 - 0.92 8.6 6.7 1.1 8.4 0.1 2.3 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Blo-t-5 PF11642.8 AIC15214.1 - 6 6.9 9.7 1.2 9.1 1.1 3.5 3 1 1 4 4 4 0 Mite allergen Blo t 5 CheC PF04509.12 AIC15215.1 - 2.1e-07 30.7 0.1 4.6e-07 29.6 0.1 1.7 1 0 0 1 1 1 1 CheC-like family CheX PF13690.6 AIC15215.1 - 0.00099 19.2 0.0 0.0026 17.9 0.0 1.7 2 0 0 2 2 2 1 Chemotaxis phosphatase CheX CheD PF03975.13 AIC15216.1 - 7.7e-30 103.2 0.3 1e-29 102.8 0.3 1.1 1 0 0 1 1 1 1 CheD chemotactic sensory transduction Cu-oxidase_4 PF02578.15 AIC15216.1 - 0.094 12.3 0.7 0.15 11.6 0.1 1.5 2 0 0 2 2 2 0 Multi-copper polyphenol oxidoreductase laccase CheR PF01739.18 AIC15217.1 - 1.7e-55 187.5 0.0 2.1e-55 187.3 0.0 1.1 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain CheR_N PF03705.15 AIC15217.1 - 5e-12 45.3 1.6 1.1e-11 44.2 1.6 1.6 1 0 0 1 1 1 1 CheR methyltransferase, all-alpha domain Methyltransf_31 PF13847.6 AIC15217.1 - 8.2e-08 32.2 0.1 0.006 16.4 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15217.1 - 1.1e-07 32.5 0.0 3.1e-07 31.1 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15217.1 - 1.8e-07 31.7 0.2 2.7e-05 24.8 0.2 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC15217.1 - 1.2e-06 29.0 0.2 2.6e-05 24.8 0.2 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15217.1 - 0.00017 21.4 0.0 0.00024 21.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_2 PF00891.18 AIC15217.1 - 0.00067 19.0 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain NodS PF05401.11 AIC15217.1 - 0.048 13.3 0.1 0.18 11.4 0.0 1.8 1 1 1 2 2 2 0 Nodulation protein S (NodS) T2SSE PF00437.20 AIC15218.1 - 3e-42 144.6 0.0 4.3e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein TrmB PF01978.19 AIC15219.1 - 7.8e-14 51.3 0.3 6.3e-13 48.4 0.1 2.5 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 AIC15219.1 - 0.065 13.1 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_IclR PF09339.10 AIC15219.1 - 0.11 12.3 1.0 0.15 11.9 0.1 1.6 2 0 0 2 2 2 0 IclR helix-turn-helix domain Arch_flagellin PF01917.16 AIC15220.1 - 1.5e-29 103.3 12.1 3e-29 102.3 12.1 1.4 1 1 0 1 1 1 1 Archaebacterial flagellin Rad33 PF08730.10 AIC15220.1 - 0.061 13.3 0.0 0.09 12.8 0.0 1.2 1 0 0 1 1 1 0 Rad33 Arch_flagellin PF01917.16 AIC15221.1 - 2.3e-23 83.2 14.9 3.1e-23 82.7 14.9 1.2 1 0 0 1 1 1 1 Archaebacterial flagellin Peptidase_M4 PF01447.18 AIC15221.1 - 0.05 14.1 0.3 0.072 13.6 0.3 1.3 1 0 0 1 1 1 0 Thermolysin metallopeptidase, catalytic domain NDUF_B12 PF08122.12 AIC15221.1 - 0.72 9.9 3.0 37 4.5 0.0 3.5 3 1 1 4 4 4 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF1664 PF07889.12 AIC15222.1 - 0.098 12.7 0.5 0.21 11.6 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Borrelia_REV PF03978.13 AIC15222.1 - 0.14 12.1 0.3 0.36 10.8 0.1 1.7 2 0 0 2 2 2 0 Borrelia burgdorferi REV protein Arch_flagellin PF01917.16 AIC15223.1 - 7.4e-12 45.8 4.3 8.9e-12 45.5 4.3 1.0 1 0 0 1 1 1 1 Archaebacterial flagellin ATPase PF06745.13 AIC15225.1 - 2.3e-21 76.2 0.2 2.6e-21 76.0 0.2 1.0 1 0 0 1 1 1 1 KaiC Rad51 PF08423.11 AIC15225.1 - 8.1e-06 25.3 0.0 1.1e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Rad51 PAXNEB PF05625.11 AIC15225.1 - 0.00029 20.1 0.6 0.0077 15.4 0.1 2.1 2 0 0 2 2 2 1 PAXNEB protein AAA_25 PF13481.6 AIC15225.1 - 0.00037 20.1 0.0 0.00049 19.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC15225.1 - 0.00042 20.7 0.0 0.00058 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 AIC15225.1 - 0.00085 19.1 0.0 0.0012 18.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain Elong_Iki1 PF10483.9 AIC15225.1 - 0.0025 17.4 0.5 0.0056 16.2 0.2 1.6 1 1 1 2 2 2 1 Elongator subunit Iki1 DUF835 PF05763.12 AIC15225.1 - 0.0043 16.8 0.2 0.0091 15.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF835) RAP1 PF07218.11 AIC15225.1 - 0.0062 14.9 0.1 0.0072 14.7 0.1 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) AAA_14 PF13173.6 AIC15225.1 - 0.01 15.8 0.3 0.027 14.5 0.3 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AIC15225.1 - 0.011 16.2 0.0 0.017 15.6 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_7 PF12775.7 AIC15225.1 - 0.016 14.7 0.1 0.031 13.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Bac_DnaA PF00308.18 AIC15225.1 - 0.02 14.8 0.1 1.4 8.7 0.0 2.2 2 0 0 2 2 2 0 Bacterial dnaA protein DUF815 PF05673.13 AIC15225.1 - 0.028 13.6 0.0 0.049 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ATPase_2 PF01637.18 AIC15225.1 - 0.043 13.7 0.0 0.062 13.2 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NACHT PF05729.12 AIC15225.1 - 0.048 13.6 0.1 0.12 12.3 0.1 1.6 2 0 0 2 2 2 0 NACHT domain Ras PF00071.22 AIC15225.1 - 0.05 13.2 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 Ras family MinE PF03776.14 AIC15225.1 - 0.072 13.1 0.2 0.24 11.5 0.0 1.8 2 0 0 2 2 2 0 Septum formation topological specificity factor MinE RNA_helicase PF00910.22 AIC15225.1 - 0.076 13.4 0.1 0.2 12.1 0.0 1.7 2 0 0 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 AIC15225.1 - 0.099 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 AIC15225.1 - 0.11 12.3 0.0 0.42 10.3 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein T2SSF PF00482.23 AIC15226.1 - 9.5e-06 25.6 0.6 9.5e-06 25.6 0.6 3.3 3 0 0 3 3 3 2 Type II secretion system (T2SS), protein F Abhydrolase_9_N PF15420.6 AIC15226.1 - 0.1 12.6 1.4 0.29 11.1 0.0 2.4 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Goodbye PF17109.5 AIC15226.1 - 0.17 12.3 1.3 0.54 10.7 0.1 2.4 3 0 0 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF2207 PF09972.9 AIC15226.1 - 4.5 5.9 7.8 1.4 7.6 1.3 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) NitrOD5 PF11537.8 AIC15227.1 - 9e-07 28.9 0.0 1.2e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 Nitrosopumilus output domain 5 ATPase PF06745.13 AIC15229.1 - 5.2e-52 176.5 1.8 1.5e-51 174.9 1.8 1.6 1 1 0 1 1 1 1 KaiC DnaB_C PF03796.15 AIC15229.1 - 6.7e-06 25.6 0.2 3.2e-05 23.4 0.0 1.8 1 1 1 2 2 2 1 DnaB-like helicase C terminal domain RecA PF00154.21 AIC15229.1 - 1.1e-05 25.0 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein AAA_14 PF13173.6 AIC15229.1 - 2.9e-05 24.1 0.2 0.00017 21.6 0.2 2.0 1 1 1 2 2 2 1 AAA domain AAA_25 PF13481.6 AIC15229.1 - 5.3e-05 22.9 0.0 9.2e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AIC15229.1 - 0.00013 21.8 0.1 0.00067 19.4 0.0 1.9 2 0 0 2 2 2 1 IstB-like ATP binding protein DUF2075 PF09848.9 AIC15229.1 - 0.00022 20.6 0.0 0.00028 20.2 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_16 PF13191.6 AIC15229.1 - 0.00022 21.6 0.0 0.00033 21.1 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Rad51 PF08423.11 AIC15229.1 - 0.00042 19.7 0.3 0.0009 18.6 0.3 1.5 1 1 0 1 1 1 1 Rad51 AAA_24 PF13479.6 AIC15229.1 - 0.0007 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain Parvo_NS1 PF01057.17 AIC15229.1 - 0.0044 16.1 0.2 0.021 13.9 0.1 1.8 1 1 1 2 2 2 1 Parvovirus non-structural protein NS1 GvpD PF07088.11 AIC15229.1 - 0.0065 15.1 0.5 0.083 11.5 0.5 2.0 1 1 0 1 1 1 1 GvpD gas vesicle protein AAA_18 PF13238.6 AIC15229.1 - 0.0069 16.9 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 AIC15229.1 - 0.0088 15.5 0.5 0.072 12.5 0.1 2.2 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 AIC15229.1 - 0.014 15.7 0.1 0.028 14.7 0.1 1.6 1 1 0 1 1 1 0 AAA domain DEAD PF00270.29 AIC15229.1 - 0.019 14.8 0.0 0.029 14.1 0.0 1.3 1 0 0 1 1 1 0 DEAD/DEAH box helicase TIP49 PF06068.13 AIC15229.1 - 0.02 14.1 0.1 0.042 13.0 0.0 1.6 2 0 0 2 2 2 0 TIP49 P-loop domain NACHT PF05729.12 AIC15229.1 - 0.021 14.8 0.0 0.052 13.5 0.0 1.6 1 1 0 1 1 1 0 NACHT domain AAA_19 PF13245.6 AIC15229.1 - 0.024 15.0 0.4 0.1 13.0 0.4 2.1 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 AIC15229.1 - 0.076 13.2 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AIC15229.1 - 0.13 12.0 0.1 0.18 11.5 0.1 1.4 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 AIC15229.1 - 0.15 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_7 PF12775.7 AIC15229.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region PIF1 PF05970.14 AIC15229.1 - 0.45 9.6 2.5 2.7 7.0 0.2 2.1 1 1 1 2 2 2 0 PIF1-like helicase LRR_3 PF07725.12 AIC15229.1 - 0.59 10.1 3.7 11 6.1 0.0 2.9 3 0 0 3 3 3 0 Leucine Rich Repeat MASE3 PF17159.4 AIC15230.1 - 7.2e-13 48.7 18.2 7.2e-13 48.7 18.2 1.4 2 0 0 2 2 2 1 Membrane-associated sensor domain LRR19-TM PF15176.6 AIC15230.1 - 0.92 9.5 4.6 2.2 8.3 0.1 2.9 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain TrmB PF01978.19 AIC15232.1 - 7.8e-14 51.3 0.2 1.7e-13 50.2 0.2 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIC15232.1 - 0.054 14.0 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 Winged helix DNA-binding domain FUR PF01475.19 AIC15232.1 - 0.083 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Ferric uptake regulator family Arc_PepC_II PF06847.11 AIC15234.1 - 5.2e-08 33.3 0.2 1.5e-07 31.8 0.2 1.7 2 0 0 2 2 2 1 Archaeal Peptidase A24 C-terminus Type II Peptidase_A24 PF01478.18 AIC15234.1 - 6.6e-06 26.5 6.2 6.6e-06 26.5 6.2 2.1 2 0 0 2 2 2 1 Type IV leader peptidase family GFO_IDH_MocA PF01408.22 AIC15235.1 - 2.8e-27 95.9 0.0 4.7e-27 95.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold GFO_IDH_MocA_C PF02894.17 AIC15235.1 - 6.4e-07 29.4 0.0 1.9e-06 27.9 0.0 1.9 2 0 0 2 2 2 1 Oxidoreductase family, C-terminal alpha/beta domain AlaDh_PNT_C PF01262.21 AIC15235.1 - 0.00015 21.1 0.0 0.00021 20.7 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain 2-Hacid_dh_C PF02826.19 AIC15235.1 - 0.0019 17.6 0.0 0.0038 16.6 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AIC15235.1 - 0.0023 17.5 0.0 0.0046 16.5 0.0 1.5 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Semialdhyde_dh PF01118.24 AIC15235.1 - 0.0042 17.5 0.0 0.0087 16.5 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AIC15235.1 - 0.0057 16.7 0.0 0.011 15.8 0.0 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Putative_PNPOx PF01243.20 AIC15237.1 - 6.2e-13 48.7 0.0 9.6e-13 48.1 0.0 1.4 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIC15237.1 - 1.1e-08 35.2 0.0 1.5e-08 34.7 0.0 1.3 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIC15237.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.4 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like WD40_3 PF15911.5 AIC15237.1 - 0.14 12.1 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 WD domain, G-beta repeat AMP-binding PF00501.28 AIC15238.1 - 2.5e-96 322.8 0.1 3.1e-96 322.6 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AIC15238.1 - 4.9e-23 81.9 0.5 4.9e-23 81.9 0.5 2.1 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AIC15238.1 - 1.1e-21 76.5 0.7 3e-21 75.1 0.7 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus MethyltransfD12 PF02086.15 AIC15239.1 - 1.6e-45 155.8 0.0 1.8e-45 155.6 0.0 1.2 1 0 0 1 1 1 1 D12 class N6 adenine-specific DNA methyltransferase Cons_hypoth95 PF03602.15 AIC15239.1 - 0.01 15.5 0.1 3.4 7.3 0.1 2.8 2 1 1 3 3 3 0 Conserved hypothetical protein 95 CBFD_NFYB_HMF PF00808.23 AIC15241.1 - 6.2e-17 61.6 0.3 7.5e-17 61.4 0.3 1.0 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Histone PF00125.24 AIC15241.1 - 1e-08 35.6 0.3 1.2e-08 35.4 0.3 1.0 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 AIC15241.1 - 5.7e-07 29.6 0.1 6.4e-07 29.5 0.1 1.0 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CENP-S PF15630.6 AIC15241.1 - 0.00019 21.8 0.1 0.0002 21.7 0.1 1.1 1 0 0 1 1 1 1 CENP-S protein TFIID-31kDa PF02291.15 AIC15241.1 - 0.0012 18.9 0.0 0.0014 18.7 0.0 1.0 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit TAF PF02969.17 AIC15241.1 - 0.0024 18.0 0.5 0.0028 17.8 0.5 1.1 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Bromo_TP PF07524.13 AIC15241.1 - 0.0031 17.5 0.0 0.0037 17.3 0.0 1.0 1 0 0 1 1 1 1 Bromodomain associated TFIID-18kDa PF02269.16 AIC15241.1 - 0.079 13.0 0.0 0.085 12.9 0.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IID, 18kD subunit TatD_DNase PF01026.21 AIC15242.1 - 9.4e-43 146.4 0.0 1.1e-42 146.2 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Ribosomal_S17e PF00833.18 AIC15243.1 - 3.2e-15 56.1 0.6 3.3e-15 56.1 0.6 1.0 1 0 0 1 1 1 1 Ribosomal S17 ThiS PF02597.20 AIC15244.1 - 1.6e-09 38.3 0.5 7.6e-09 36.1 0.1 2.3 2 1 1 3 3 3 1 ThiS family CGI-121 PF08617.10 AIC15244.1 - 2.9e-07 30.7 0.0 4.4e-07 30.2 0.0 1.2 1 0 0 1 1 1 1 Kinase binding protein CGI-121 Urm1 PF09138.11 AIC15244.1 - 0.003 17.9 0.1 0.0079 16.5 0.1 1.8 1 1 0 1 1 1 1 Urm1 (Ubiquitin related modifier) TrkA_C PF02080.21 AIC15244.1 - 0.031 14.1 0.6 0.96 9.3 0.2 2.6 2 0 0 2 2 2 0 TrkA-C domain THUMP PF02926.17 AIC15245.1 - 7.7e-15 55.2 0.4 9.1e-15 55.0 0.4 1.2 1 0 0 1 1 1 1 THUMP domain Sua5_yciO_yrdC PF01300.18 AIC15246.1 - 5e-45 153.2 0.0 5.8e-45 153.0 0.0 1.0 1 0 0 1 1 1 1 Telomere recombination Hydantoinase_A PF01968.18 AIC15247.1 - 3.6e-59 200.4 4.5 3.6e-59 200.4 4.5 2.1 2 0 0 2 2 2 1 Hydantoinase/oxoprolinase Hydant_A_N PF05378.13 AIC15247.1 - 3.1e-21 75.9 3.2 3.1e-21 75.9 3.2 3.8 5 1 0 5 5 5 1 Hydantoinase/oxoprolinase N-terminal region MutL PF13941.6 AIC15247.1 - 1.5e-06 27.1 4.9 0.00013 20.7 1.4 2.3 2 0 0 2 2 2 2 MutL protein FGGY_N PF00370.21 AIC15247.1 - 0.00015 21.4 0.9 0.00042 20.0 0.9 1.8 1 1 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain BcrAD_BadFG PF01869.20 AIC15247.1 - 0.00017 21.2 0.4 0.00017 21.2 0.4 3.4 3 1 0 3 3 3 1 BadF/BadG/BcrA/BcrD ATPase family FtsA PF14450.6 AIC15247.1 - 0.03 14.8 3.8 1.1 9.8 0.3 3.2 3 0 0 3 3 3 0 Cell division protein FtsA DUF4229 PF14012.6 AIC15248.1 - 0.0003 20.8 1.7 0.00034 20.6 1.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4229) DUF3487 PF11990.8 AIC15248.1 - 0.064 13.1 0.9 0.11 12.4 0.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3487) DUF5490 PF17593.2 AIC15248.1 - 0.21 11.6 0.2 0.31 11.1 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5490) Gram_pos_anchor PF00746.21 AIC15249.1 - 0.00016 21.5 0.7 0.15 12.1 0.4 2.5 3 0 0 3 3 3 2 LPXTG cell wall anchor motif KbaA PF14089.6 AIC15249.1 - 0.0011 18.9 0.2 0.0011 18.9 0.2 1.0 1 0 0 1 1 1 1 KinB-signalling pathway activation in sporulation DUF2157 PF09925.9 AIC15249.1 - 0.0014 18.4 0.4 0.0017 18.1 0.4 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2157) DUF1129 PF06570.11 AIC15249.1 - 0.0025 17.3 0.4 0.0029 17.1 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) YfhO PF09586.10 AIC15249.1 - 0.0035 15.7 0.2 0.0036 15.6 0.2 1.0 1 0 0 1 1 1 1 Bacterial membrane protein YfhO MerC PF03203.14 AIC15249.1 - 0.0039 17.6 0.3 0.0054 17.2 0.3 1.1 1 0 0 1 1 1 1 MerC mercury resistance protein Branch_AA_trans PF05525.13 AIC15249.1 - 0.0041 16.1 0.2 0.0045 15.9 0.2 1.0 1 0 0 1 1 1 1 Branched-chain amino acid transport protein EpsG PF14897.6 AIC15249.1 - 0.0076 15.6 0.4 0.0099 15.2 0.4 1.1 1 0 0 1 1 1 1 EpsG family Mntp PF02659.15 AIC15249.1 - 0.008 15.9 0.3 0.0093 15.7 0.3 1.0 1 0 0 1 1 1 1 Putative manganese efflux pump Tmemb_14 PF03647.13 AIC15249.1 - 0.023 15.4 0.8 0.074 13.8 0.8 1.8 1 1 0 1 1 1 0 Transmembrane proteins 14C DUF2304 PF10066.9 AIC15249.1 - 0.033 14.4 1.1 0.15 12.3 1.2 1.8 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2304) DUF4131 PF13567.6 AIC15249.1 - 0.066 12.9 1.0 1.2 8.8 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4131) DUF202 PF02656.15 AIC15249.1 - 0.068 13.6 2.5 1 9.8 2.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Ceramidase PF05875.12 AIC15249.1 - 0.096 12.1 0.4 0.11 11.9 0.4 1.0 1 0 0 1 1 1 0 Ceramidase PEP-CTERM PF07589.11 AIC15249.1 - 0.1 12.7 0.8 4.5 7.5 0.1 2.4 2 0 0 2 2 2 0 PEP-CTERM motif CrgA PF06781.12 AIC15249.1 - 0.13 12.3 1.2 0.17 11.9 0.3 1.6 1 1 1 2 2 2 0 Cell division protein CrgA TctB PF07331.11 AIC15249.1 - 0.16 12.2 4.0 0.23 11.7 0.5 2.0 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF4536 PF15055.6 AIC15249.1 - 0.22 11.8 2.4 2.9 8.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) FeoB_associated PF12669.7 AIC15249.1 - 1.3 9.5 2.9 12 6.4 0.2 2.7 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein DDE_Tnp_IS240 PF13610.6 AIC15250.1 - 6.9e-19 68.5 0.8 1.6e-18 67.3 0.8 1.6 1 0 0 1 1 1 1 DDE domain rve PF00665.26 AIC15250.1 - 4e-06 27.0 0.0 8.8e-06 25.9 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 AIC15250.1 - 0.00026 20.7 0.2 0.00083 19.1 0.2 1.9 1 0 0 1 1 1 1 Integrase core domain Elf1 PF05129.13 AIC15250.1 - 0.013 15.6 2.0 0.026 14.6 1.6 1.7 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like SWIM PF04434.17 AIC15250.1 - 0.014 15.1 0.5 0.014 15.1 0.5 1.8 2 0 0 2 2 2 0 SWIM zinc finger EPF PF17181.4 AIC15250.1 - 0.053 13.5 2.9 0.14 12.2 0.0 2.4 2 0 0 2 2 2 0 Epidermal patterning factor proteins Transposase_mut PF00872.18 AIC15250.1 - 0.059 12.2 0.1 2.8 6.7 0.0 2.1 2 0 0 2 2 2 0 Transposase, Mutator family Zn_Tnp_IS1 PF03811.13 AIC15250.1 - 0.065 13.0 1.0 0.22 11.3 1.0 2.0 1 0 0 1 1 1 0 InsA N-terminal domain zf-Dof PF02701.15 AIC15250.1 - 8.8 6.6 10.1 0.37 11.0 3.5 2.0 2 0 0 2 2 2 0 Dof domain, zinc finger MazE_antitoxin PF04014.18 AIC15251.1 - 1.5e-05 24.8 0.1 2.4e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin DUF267 PF03268.14 AIC15252.1 - 0.032 13.1 0.3 0.062 12.2 0.1 1.4 1 1 0 1 1 1 0 Caenorhabditis protein of unknown function, DUF267 DDE_Tnp_IS240 PF13610.6 AIC15255.1 - 1.2e-15 58.0 0.6 1.5e-15 57.7 0.6 1.1 1 0 0 1 1 1 1 DDE domain rve_3 PF13683.6 AIC15255.1 - 7.9e-07 28.8 0.1 1.6e-06 27.8 0.1 1.6 1 1 0 1 1 1 1 Integrase core domain rve PF00665.26 AIC15255.1 - 8.1e-05 22.8 0.1 0.00015 21.9 0.1 1.4 1 1 0 1 1 1 1 Integrase core domain MULE PF10551.9 AIC15255.1 - 0.066 13.6 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 MULE transposase domain PhnH PF05845.12 AIC15255.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial phosphonate metabolism protein (PhnH) V4R PF02830.18 AIC15256.1 - 8.9e-14 51.2 0.2 1.5e-13 50.6 0.2 1.4 1 0 0 1 1 1 1 V4R domain YhcG_C PF06250.11 AIC15256.1 - 0.033 14.0 0.0 0.044 13.6 0.0 1.1 1 0 0 1 1 1 0 YhcG PDDEXK nuclease domain HTH_24 PF13412.6 AIC15257.1 - 1.5e-07 30.9 1.3 1.6e-07 30.8 0.2 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC15257.1 - 8.8e-07 28.7 0.3 3.9e-06 26.6 0.1 2.2 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_50 PF18024.1 AIC15257.1 - 0.0021 17.6 0.0 0.0051 16.4 0.0 1.6 1 0 0 1 1 1 1 Helix-turn-helix domain TrmB PF01978.19 AIC15257.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 AIC15257.1 - 0.027 14.5 0.0 0.053 13.6 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_23 PF13384.6 AIC15257.1 - 0.053 13.3 0.0 0.2 11.5 0.0 1.9 2 0 0 2 2 2 0 Homeodomain-like domain HTH_psq PF05225.16 AIC15257.1 - 0.065 13.0 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 helix-turn-helix, Psq domain HTH_8 PF02954.19 AIC15257.1 - 0.12 12.2 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Sipho_tail PF05709.11 AIC15257.1 - 0.13 11.6 0.1 0.21 11.0 0.1 1.2 1 0 0 1 1 1 0 Phage tail protein UDPG_MGDP_dh PF00984.19 AIC15258.1 - 1.9e-19 69.7 0.1 2.9e-19 69.1 0.1 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 AIC15258.1 - 9.7e-10 38.3 0.0 0.00043 19.9 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 AIC15258.1 - 0.00023 21.3 0.0 0.00036 20.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 AIC15258.1 - 0.00038 19.9 0.0 0.0006 19.2 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 AIC15258.1 - 0.0016 18.4 0.1 0.01 15.8 0.0 2.0 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain TrkA_N PF02254.18 AIC15258.1 - 0.0094 16.2 0.1 0.022 15.0 0.1 1.6 1 0 0 1 1 1 1 TrkA-N domain Mur_ligase PF01225.25 AIC15258.1 - 0.052 13.9 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, catalytic domain AlaDh_PNT_C PF01262.21 AIC15258.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain HTH_45 PF14947.6 AIC15259.1 - 3.2e-16 59.1 0.1 3.6e-16 58.9 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix Mrr_N PF14338.6 AIC15259.1 - 0.049 13.8 0.1 0.062 13.4 0.1 1.3 1 0 0 1 1 1 0 Mrr N-terminal domain HTH_24 PF13412.6 AIC15260.1 - 3.1e-06 26.7 0.4 6e-06 25.7 0.4 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC15260.1 - 0.0013 18.5 0.2 0.0027 17.5 0.2 1.6 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIC15260.1 - 0.0015 18.4 0.1 0.0036 17.2 0.1 1.6 1 0 0 1 1 1 1 HTH domain HTH_23 PF13384.6 AIC15260.1 - 0.014 15.2 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain AsnC_trans_reg PF01037.21 AIC15260.1 - 0.017 15.0 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 Lrp/AsnC ligand binding domain HTH_20 PF12840.7 AIC15260.1 - 0.017 15.1 0.1 0.042 13.9 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_8 PF02954.19 AIC15260.1 - 0.053 13.3 0.0 0.15 11.9 0.0 1.9 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family TrmB PF01978.19 AIC15260.1 - 0.06 13.2 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIC15261.1 - 1.4e-06 27.8 1.4 8.1e-06 25.3 0.2 2.6 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC15261.1 - 0.00091 19.0 0.1 0.0074 16.1 0.1 2.3 2 1 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_11 PF08279.12 AIC15261.1 - 0.0012 18.8 0.2 0.0026 17.7 0.2 1.6 1 0 0 1 1 1 1 HTH domain HTH_20 PF12840.7 AIC15261.1 - 0.0022 18.0 0.6 0.0097 15.9 0.1 2.1 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_23 PF13384.6 AIC15261.1 - 0.01 15.6 0.0 0.03 14.1 0.0 1.7 1 0 0 1 1 1 0 Homeodomain-like domain TrmB PF01978.19 AIC15261.1 - 0.033 14.1 0.1 0.2 11.5 0.0 2.0 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB ACT_4 PF13291.6 AIC15261.1 - 0.059 14.0 0.2 0.23 12.1 0.1 2.1 2 1 0 2 2 2 0 ACT domain DUF2116 PF09889.9 AIC15262.1 - 0.02 14.9 11.8 0.31 11.0 6.9 2.2 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) ASFV_p27 PF06556.11 AIC15262.1 - 0.065 13.3 0.9 0.093 12.8 0.9 1.2 1 0 0 1 1 1 0 IAP-like protein p27 C-terminus zf-C3HC4_3 PF13920.6 AIC15262.1 - 2.7 7.9 13.0 0.91 9.4 9.9 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4512 PF14975.6 AIC15265.1 - 0.46 11.3 3.3 0.84 10.5 3.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4512) SIS PF01380.22 AIC15266.1 - 6.2e-53 178.1 1.9 4.6e-30 104.1 1.4 2.6 2 0 0 2 2 2 2 SIS domain GATase_6 PF13522.6 AIC15266.1 - 2.5e-22 79.5 0.0 5e-22 78.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 AIC15266.1 - 3e-16 59.4 0.0 6e-16 58.5 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 AIC15266.1 - 0.00016 21.7 0.8 0.00016 21.7 0.8 2.8 3 1 1 4 4 4 1 SIS domain GATase_4 PF13230.6 AIC15266.1 - 0.0027 16.7 0.1 0.0058 15.6 0.1 1.5 1 0 0 1 1 1 1 Glutamine amidotransferases class-II F5_F8_type_C PF00754.25 AIC15269.1 - 7.4e-16 58.4 1.7 3.3e-15 56.3 1.7 2.2 1 0 0 1 1 1 1 F5/8 type C domain Big_7 PF17957.1 AIC15269.1 - 9.1e-07 29.6 0.9 9.1e-07 29.6 0.9 3.0 2 0 0 2 2 2 1 Bacterial Ig domain CBM_6 PF03422.15 AIC15269.1 - 0.0023 18.3 0.3 0.0023 18.3 0.3 2.8 3 0 0 3 3 3 1 Carbohydrate binding module (family 6) CHB_HEX_C_1 PF13290.6 AIC15270.1 - 8.2e-119 387.7 76.5 2.8e-21 75.3 5.2 8.1 8 0 0 8 8 8 6 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIC15270.1 - 4.8e-98 321.3 54.4 7.7e-19 67.6 1.5 7.6 7 0 0 7 7 7 6 Fn3 associated CHB_HEX_C PF03174.13 AIC15270.1 - 8.9e-26 89.7 4.0 0.00014 21.7 0.0 6.5 6 0 0 6 6 6 6 Chitobiase/beta-hexosaminidase C-terminal domain HYR PF02494.16 AIC15270.1 - 4.3e-11 43.0 18.0 4.3e-06 27.0 1.7 5.2 5 0 0 5 5 5 2 HYR domain Polysacc_deac_1 PF01522.21 AIC15270.1 - 3.1e-10 40.0 0.0 6.8e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 AIC15270.1 - 0.0031 16.7 0.0 0.0049 16.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 TrkA_C PF02080.21 AIC15270.1 - 0.034 14.0 0.0 22 5.0 0.0 3.2 4 0 0 4 4 4 0 TrkA-C domain Rimk_N PF18030.1 AIC15270.1 - 0.11 13.0 0.0 0.23 11.9 0.0 1.5 1 0 0 1 1 1 0 RimK PreATP-grasp domain VERL PF11386.8 AIC15270.1 - 2.8 8.2 4.9 59 3.9 0.1 4.0 4 0 0 4 4 4 0 Vitelline envelope receptor for lysin Beta_helix PF13229.6 AIC15271.1 - 3.6e-21 75.7 30.9 7.7e-14 51.8 14.1 2.7 1 1 1 2 2 2 2 Right handed beta helix region NosD PF05048.13 AIC15271.1 - 2.6e-19 69.4 15.4 6.2e-19 68.2 15.4 1.6 1 0 0 1 1 1 1 Periplasmic copper-binding protein (NosD) DUF1565 PF07602.11 AIC15271.1 - 0.00044 19.7 11.8 0.071 12.4 12.5 2.7 1 1 1 2 2 2 2 Protein of unknown function (DUF1565) Polysacc_deac_1 PF01522.21 AIC15271.1 - 0.071 13.0 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide deacetylase Glycos_transf_2 PF00535.26 AIC15272.1 - 1.3e-30 106.4 0.0 2.4e-30 105.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIC15272.1 - 2e-21 77.0 0.1 4.2e-21 75.9 0.1 1.4 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AIC15272.1 - 8.3e-17 61.0 0.2 2.1e-15 56.4 0.2 2.1 1 1 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AIC15272.1 - 8.9e-09 35.5 5.7 8.9e-09 35.5 5.7 2.6 3 1 0 3 3 3 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIC15272.1 - 9e-09 35.0 3.2 5.5e-07 29.2 0.0 2.7 3 0 0 3 3 3 2 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIC15272.1 - 5.3e-05 22.8 0.0 7.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 YjgF_endoribonc PF14588.6 AIC15273.1 - 2.9e-42 144.3 0.0 3.3e-42 144.1 0.0 1.0 1 0 0 1 1 1 1 YjgF/chorismate_mutase-like, putative endoribonuclease Ribonuc_L-PSP PF01042.21 AIC15273.1 - 1.5e-22 79.9 0.0 2.1e-22 79.4 0.0 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP BofA PF07441.11 AIC15274.1 - 0.064 13.5 0.1 0.081 13.1 0.1 1.0 1 0 0 1 1 1 0 SigmaK-factor processing regulatory protein BofA DHHA1 PF02272.19 AIC15275.1 - 6.1e-16 59.1 0.4 1.4e-15 57.9 0.4 1.6 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 AIC15275.1 - 1.7e-05 25.0 0.1 4.7e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 DHH family HMGL-like PF00682.19 AIC15275.1 - 0.032 13.8 0.1 0.061 12.9 0.1 1.5 1 0 0 1 1 1 0 HMGL-like Thioredox_DsbH PF03190.15 AIC15278.1 - 3.4e-33 114.9 0.0 5.3e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Glyco_hydro_88 PF07470.13 AIC15278.1 - 3.4e-11 42.8 0.0 7.6e-05 21.9 0.0 2.6 2 1 0 2 2 2 2 Glycosyl Hydrolase Family 88 Glyco_hydro_76 PF03663.14 AIC15278.1 - 2.2e-08 34.0 0.1 0.00015 21.5 0.0 2.9 1 1 2 3 3 3 2 Glycosyl hydrolase family 76 C5-epim_C PF06662.13 AIC15278.1 - 6.4e-07 29.1 1.9 0.00055 19.5 0.1 3.6 4 0 0 4 4 4 2 D-glucuronyl C5-epimerase C-terminus GlcNAc_2-epim PF07221.11 AIC15278.1 - 0.0002 20.7 0.2 19 4.4 0.0 3.2 2 1 0 2 2 2 1 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) Glyco_hydro_127 PF07944.12 AIC15278.1 - 0.0026 16.3 0.0 0.045 12.2 0.0 2.5 3 0 0 3 3 3 1 Beta-L-arabinofuranosidase, GH127 PMBR PF09373.10 AIC15278.1 - 0.0085 16.2 0.1 10 6.5 0.0 3.2 2 0 0 2 2 2 2 Pseudomurein-binding repeat DUF5106 PF17127.4 AIC15278.1 - 0.11 12.7 0.3 0.49 10.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5106) KdpD PF02702.17 AIC15279.1 - 0.032 13.7 0.8 0.041 13.4 0.8 1.0 1 0 0 1 1 1 0 Osmosensitive K+ channel His kinase sensor domain Cluap1 PF10234.9 AIC15279.1 - 0.037 13.4 1.0 0.042 13.2 1.0 1.0 1 0 0 1 1 1 0 Clusterin-associated protein-1 Polysacc_synt_C PF14667.6 AIC15280.1 - 0.017 15.2 2.8 0.02 15.0 2.8 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain DUF998 PF06197.13 AIC15280.1 - 0.022 14.4 0.7 0.025 14.2 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF998) Popeye PF04831.13 AIC15280.1 - 0.057 13.6 0.0 0.057 13.6 0.0 1.1 1 0 0 1 1 1 0 Popeye protein conserved region Pyridox_ox_2 PF12900.7 AIC15281.1 - 6.5e-23 81.3 0.0 7.8e-23 81.0 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Putative_PNPOx PF01243.20 AIC15281.1 - 5.9e-14 52.0 0.0 1.4e-13 50.8 0.0 1.6 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase FMN_bind_2 PF04299.12 AIC15281.1 - 6.4e-06 26.0 0.0 7.7e-06 25.7 0.0 1.2 1 0 0 1 1 1 1 Putative FMN-binding domain LCD1 PF09798.9 AIC15282.1 - 0.22 10.0 0.2 0.24 9.9 0.2 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein HTH_45 PF14947.6 AIC15283.1 - 3e-19 68.8 0.4 3.3e-19 68.6 0.4 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC15283.1 - 0.0032 17.2 0.0 0.0034 17.1 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) FokI_C PF02980.16 AIC15283.1 - 0.12 12.4 0.2 0.57 10.2 0.1 1.8 1 1 1 2 2 2 0 Restriction endonuclease FokI, catalytic domain PadR PF03551.14 AIC15284.1 - 1e-10 41.4 0.0 4.4e-10 39.4 0.0 2.0 1 1 1 2 2 2 1 Transcriptional regulator PadR-like family HTH_45 PF14947.6 AIC15284.1 - 0.00018 21.4 0.0 0.00038 20.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix RTP PF02334.16 AIC15284.1 - 0.029 15.0 0.0 0.051 14.2 0.0 1.4 1 0 0 1 1 1 0 Replication terminator protein Mrr_N PF14338.6 AIC15284.1 - 0.093 12.9 0.2 1 9.5 0.0 2.6 3 1 1 4 4 4 0 Mrr N-terminal domain Ribonuc_L-PSP PF01042.21 AIC15285.1 - 5.6e-24 84.5 0.3 6.8e-24 84.2 0.3 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP MEDS PF14417.6 AIC15287.1 - 1.9e-09 37.6 0.0 3.6e-09 36.7 0.0 1.5 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATPase PF06745.13 AIC15287.1 - 0.041 13.2 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF4396 PF14342.6 AIC15289.1 - 1.4e-30 106.5 12.0 1.7e-30 106.2 12.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) Halogen_Hydrol PF10112.9 AIC15289.1 - 0.53 10.3 4.0 1.8 8.5 0.1 2.0 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein UPF0086 PF01868.16 AIC15291.1 - 0.012 15.5 0.0 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function UPF0086 DUF3215 PF11503.8 AIC15291.1 - 0.13 12.1 0.1 15 5.6 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3215) Na_H_Exchanger PF00999.21 AIC15292.1 - 3.5e-60 203.8 48.4 4.1e-60 203.6 48.4 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TetR_C_31 PF17940.1 AIC15293.1 - 0.068 13.4 0.0 0.095 12.9 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TauE PF01925.19 AIC15294.1 - 7.1e-41 140.4 38.2 8.5e-41 140.1 38.2 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE CRCB PF02537.15 AIC15297.1 - 9.2e-20 70.8 7.4 1.1e-19 70.5 7.4 1.1 1 0 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) DUF2104 PF09877.9 AIC15297.1 - 0.053 13.8 1.8 0.061 13.6 0.6 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2104) DUF190 PF02641.15 AIC15298.1 - 1.2e-21 76.9 0.1 1.3e-21 76.7 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 Cation_efflux PF01545.21 AIC15299.1 - 4.8e-38 130.9 14.9 5.7e-38 130.7 14.9 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 AIC15299.1 - 1.3e-09 38.1 0.1 2.5e-09 37.1 0.1 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter Cation_ATPase_C PF00689.21 AIC15299.1 - 3 7.5 7.8 0.32 10.7 3.0 1.8 2 0 0 2 2 2 0 Cation transporting ATPase, C-terminus UPF0154 PF03672.13 AIC15300.1 - 0.86 9.7 5.9 3.6 7.7 0.3 3.4 3 1 0 3 3 3 0 Uncharacterised protein family (UPF0154) DUF3040 PF11239.8 AIC15302.1 - 0.079 13.2 1.8 0.092 13.0 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) SKG6 PF08693.10 AIC15302.1 - 1.4 8.4 6.2 7.7 6.0 0.6 2.2 2 0 0 2 2 2 0 Transmembrane alpha-helix domain Thioredoxin_4 PF13462.6 AIC15303.1 - 5e-33 114.6 0.0 6.8e-33 114.2 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin DSBA PF01323.20 AIC15303.1 - 3.6e-14 53.0 0.4 1.1e-12 48.1 0.1 2.4 2 1 0 2 2 2 1 DSBA-like thioredoxin domain Thioredoxin_2 PF13098.6 AIC15303.1 - 8.2e-07 29.5 0.1 7.4e-06 26.4 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like domain ADIP PF11559.8 AIC15304.1 - 0.0065 16.6 17.1 0.023 14.8 4.2 2.8 3 0 0 3 3 3 2 Afadin- and alpha -actinin-Binding Bap31_Bap29_C PF18035.1 AIC15304.1 - 0.0095 15.9 0.1 0.0095 15.9 0.1 3.2 3 0 0 3 3 2 1 Bap31/Bap29 cytoplasmic coiled-coil domain DUF948 PF06103.11 AIC15304.1 - 0.011 16.0 8.0 1.6 9.1 0.0 5.2 2 1 5 7 7 7 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 AIC15304.1 - 0.04 12.8 31.3 0.11 11.4 13.0 3.0 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF4055 PF13264.6 AIC15304.1 - 0.075 13.2 12.1 0.044 13.9 5.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4055) DUF4407 PF14362.6 AIC15304.1 - 0.075 12.4 19.8 0.22 10.9 10.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) MapZ_EC1 PF18041.1 AIC15304.1 - 0.1 12.9 6.5 0.11 12.7 2.3 3.0 2 1 0 2 2 2 0 MapZ extracellular domain 1 YkyA PF10368.9 AIC15304.1 - 0.1 12.3 26.0 0.21 11.2 0.2 3.6 2 1 0 3 3 3 0 Putative cell-wall binding lipoprotein IF-2B PF01008.17 AIC15304.1 - 0.21 10.7 5.5 0.045 12.9 1.5 1.9 2 0 0 2 2 2 0 Initiation factor 2 subunit family TMF_TATA_bd PF12325.8 AIC15304.1 - 0.28 11.4 26.0 2.1 8.6 5.8 4.8 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding TolA_bind_tri PF16331.5 AIC15304.1 - 0.32 11.1 10.2 0.43 10.7 1.3 3.9 2 1 1 3 3 3 0 TolA binding protein trimerisation DUF5320 PF17253.2 AIC15304.1 - 0.67 11.1 1.9 21 6.3 0.5 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF2096 PF09869.9 AIC15304.1 - 0.71 9.9 10.4 1.5 8.9 2.5 4.1 2 2 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2096) Baculo_PEP_C PF04513.12 AIC15304.1 - 0.95 9.5 13.0 2.9 7.9 1.7 4.4 2 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Occludin_ELL PF07303.13 AIC15304.1 - 1.1 10.0 13.1 0.19 12.4 0.3 4.1 2 2 2 4 4 4 0 Occludin homology domain Cob_adeno_trans PF01923.18 AIC15304.1 - 1.4 9.0 15.9 1.5 8.9 1.5 3.9 1 1 1 4 4 4 0 Cobalamin adenosyltransferase Pup PF05639.11 AIC15304.1 - 1.8 9.5 8.7 27 5.7 0.2 4.2 3 1 1 4 4 4 0 Pup-like protein Syntaxin-6_N PF09177.11 AIC15304.1 - 3.6 8.2 16.3 4.1 8.0 0.0 4.2 3 1 1 4 4 4 0 Syntaxin 6, N-terminal TraG_N PF07916.11 AIC15304.1 - 3.9 6.2 5.9 6.8 5.4 5.9 1.3 1 0 0 1 1 1 0 TraG-like protein, N-terminal region DUF4665 PF15679.5 AIC15304.1 - 5.9 7.6 9.1 55 4.5 0.7 4.3 3 1 2 5 5 5 0 Domain of unknown function (DUF4665) Mito_fiss_reg PF05308.11 AIC15304.1 - 6.4 6.8 12.6 1.7 8.6 8.5 2.1 2 1 0 2 2 2 0 Mitochondrial fission regulator ParB PF08775.10 AIC15304.1 - 8.3 6.9 13.4 0.97 9.9 0.6 4.7 5 1 0 6 6 6 0 ParB family Fib_alpha PF08702.10 AIC15304.1 - 8.8 6.5 14.3 2.2 8.5 0.3 4.2 1 1 3 5 5 5 0 Fibrinogen alpha/beta chain family DUF2627 PF11118.8 AIC15305.1 - 0.00018 22.0 2.9 0.00048 20.7 1.0 2.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2627) EpuA PF11772.8 AIC15306.1 - 0.11 12.2 0.4 0.16 11.7 0.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta Cupin_2 PF07883.11 AIC15308.1 - 6.6e-11 41.8 0.1 8.1e-11 41.5 0.1 1.1 1 0 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 AIC15308.1 - 1.9e-05 24.3 0.0 2.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Cupin AraC_binding PF02311.19 AIC15308.1 - 0.00051 20.0 0.0 0.00062 19.7 0.0 1.2 1 0 0 1 1 1 1 AraC-like ligand binding domain CENP-C_C PF11699.8 AIC15308.1 - 0.0012 19.0 0.0 0.0016 18.6 0.0 1.1 1 0 0 1 1 1 1 Mif2/CENP-C like ARD PF03079.14 AIC15308.1 - 0.06 13.5 0.0 0.092 12.9 0.0 1.3 1 0 0 1 1 1 0 ARD/ARD' family Cupin_6 PF12852.7 AIC15308.1 - 0.1 12.3 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Cupin Cupin_3 PF05899.12 AIC15308.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF861) CarboxypepD_reg PF13620.6 AIC15311.1 - 0.0049 17.1 0.2 0.045 14.0 0.2 2.5 2 1 1 3 3 3 1 Carboxypeptidase regulatory-like domain Ppnp PF06865.11 AIC15311.1 - 0.033 14.6 0.0 0.06 13.8 0.0 1.5 1 0 0 1 1 1 0 Pyrimidine/purine nucleoside phosphorylase HTH_45 PF14947.6 AIC15312.1 - 2.6e-07 30.5 0.4 4.5e-07 29.8 0.4 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_5 PF01022.20 AIC15312.1 - 0.0016 18.3 0.1 0.013 15.4 0.0 2.1 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family DUF4364 PF14277.6 AIC15312.1 - 0.0057 16.4 0.1 0.0086 15.8 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_20 PF12840.7 AIC15312.1 - 0.0092 16.0 0.0 0.03 14.4 0.0 1.7 2 0 0 2 2 2 1 Helix-turn-helix domain DUF2897 PF11446.8 AIC15312.1 - 0.015 15.1 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) HTH_Tnp_ISL3 PF13542.6 AIC15312.1 - 0.025 14.0 0.0 1.1 8.7 0.0 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 HTH_24 PF13412.6 AIC15312.1 - 0.062 12.9 0.2 1.2 8.7 0.0 2.6 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 AIC15312.1 - 0.093 12.7 0.0 0.33 10.9 0.0 1.9 2 1 0 2 2 2 0 HTH domain DUF4423 PF14394.6 AIC15312.1 - 0.11 12.1 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) BNR_2 PF13088.6 AIC15313.1 - 8.5e-08 31.8 3.1 0.00021 20.7 0.2 3.3 1 1 2 3 3 3 3 BNR repeat-like domain BNR_4 PF15892.5 AIC15313.1 - 9.2e-06 25.2 0.5 0.015 14.7 0.0 3.0 1 1 2 3 3 3 2 BNR repeat-containing family member ChlamPMP_M PF07548.11 AIC15313.1 - 0.011 15.7 0.3 0.028 14.4 0.3 1.7 1 0 0 1 1 1 0 Chlamydia polymorphic membrane protein middle domain BNR PF02012.20 AIC15313.1 - 1.3 9.3 10.3 49 4.5 0.3 5.3 5 0 0 5 5 5 0 BNR/Asp-box repeat Ribosomal_L40e PF01020.17 AIC15314.1 - 0.00029 20.6 4.2 0.00034 20.5 4.2 1.1 1 0 0 1 1 1 1 Ribosomal L40e family DZR PF12773.7 AIC15314.1 - 0.016 15.2 1.1 0.019 15.0 1.1 1.2 1 0 0 1 1 1 0 Double zinc ribbon Paired_CXXCH_1 PF09699.10 AIC15314.1 - 0.12 12.1 2.7 0.43 10.4 0.2 2.1 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) Histone_H2A_C PF16211.5 AIC15315.1 - 0.12 12.1 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 C-terminus of histone H2A AdoHcyase PF05221.17 AIC15318.1 - 4.2e-71 239.5 0.0 7.1e-43 146.8 0.0 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 AIC15318.1 - 9.8e-56 188.3 4.5 5.8e-55 185.8 3.6 2.1 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIC15318.1 - 1.2e-10 41.1 0.8 1.2e-10 41.1 0.8 1.9 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AIC15318.1 - 2.2e-07 30.6 0.6 5.2e-07 29.4 0.6 1.6 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 AIC15318.1 - 0.00018 21.6 1.1 0.0052 16.9 0.5 2.3 1 1 1 2 2 2 1 Shikimate / quinate 5-dehydrogenase ELFV_dehydrog PF00208.21 AIC15318.1 - 0.0078 16.0 1.0 0.013 15.2 1.0 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase TrkA_N PF02254.18 AIC15318.1 - 0.02 15.1 0.5 0.055 13.7 0.2 1.9 2 0 0 2 2 2 0 TrkA-N domain F420_oxidored PF03807.17 AIC15318.1 - 0.062 13.9 1.3 0.15 12.6 1.3 1.7 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent XdhC_C PF13478.6 AIC15318.1 - 0.065 13.7 0.4 0.49 10.9 0.1 2.5 3 0 0 3 3 3 0 XdhC Rossmann domain AlaDh_PNT_C PF01262.21 AIC15318.1 - 0.26 10.6 5.6 0.87 8.8 5.6 1.8 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Pribosyltran PF00156.27 AIC15319.1 - 6.7e-25 87.5 0.1 2.6e-24 85.5 0.1 1.8 1 1 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIC15319.1 - 1.8e-06 27.6 0.1 2.6e-06 27.0 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 AIC15319.1 - 0.00098 18.7 0.0 0.0041 16.6 0.0 2.0 2 0 0 2 2 2 1 Phosphoribosyl transferase LDcluster4 PF18306.1 AIC15320.1 - 3.3e-44 150.2 4.2 3.8e-44 150.0 4.2 1.0 1 0 0 1 1 1 1 SLOG cluster4 family DNA_processg_A PF02481.15 AIC15320.1 - 2.5e-05 23.6 0.1 0.0011 18.3 0.1 2.1 2 0 0 2 2 2 1 DNA recombination-mediator protein A Lysine_decarbox PF03641.14 AIC15320.1 - 3.3e-05 24.0 0.7 0.00011 22.3 0.1 2.2 1 1 1 2 2 2 1 Possible lysine decarboxylase LSDAT_prok PF18171.1 AIC15320.1 - 0.00034 19.9 0.1 0.00087 18.6 0.0 1.7 2 0 0 2 2 2 1 SLOG in TRPM, prokaryote DAGK_cat PF00781.24 AIC15320.1 - 1 9.0 7.6 0.68 9.6 0.4 2.4 1 1 1 2 2 2 0 Diacylglycerol kinase catalytic domain 3HCDH_N PF02737.18 AIC15321.1 - 1.1e-65 220.9 0.0 3.3e-65 219.3 0.0 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 AIC15321.1 - 1.3e-31 109.0 0.4 1.9e-25 89.3 0.1 3.2 3 0 0 3 3 3 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_Gly3P_dh_N PF01210.23 AIC15321.1 - 3.4e-06 27.1 0.0 6.1e-06 26.3 0.0 1.4 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 AIC15321.1 - 0.00026 21.2 0.0 0.00049 20.3 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase UDPG_MGDP_dh_N PF03721.14 AIC15321.1 - 0.019 14.6 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain AlaDh_PNT_C PF01262.21 AIC15321.1 - 0.033 13.5 0.1 0.061 12.6 0.1 1.5 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain F420_oxidored PF03807.17 AIC15321.1 - 0.065 13.8 0.3 0.27 11.8 0.3 2.1 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent HTH_37 PF13744.6 AIC15321.1 - 0.15 12.0 0.3 0.59 10.1 0.2 2.0 1 1 1 2 2 2 0 Helix-turn-helix domain Ribosomal_L39 PF00832.20 AIC15322.1 - 1.4e-18 66.2 14.3 1.7e-18 65.9 14.3 1.2 1 0 0 1 1 1 1 Ribosomal L39 protein Ribosomal_L31e PF01198.19 AIC15323.1 - 6.1e-18 64.8 1.1 9.4e-18 64.2 1.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L31e DUF983 PF06170.12 AIC15325.1 - 0.04 14.3 0.2 0.04 14.3 0.2 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF983) zf-trcl PF13451.6 AIC15325.1 - 0.059 13.3 0.3 0.059 13.3 0.3 2.9 3 0 0 3 3 3 0 Probable zinc-ribbon domain Tubulin PF00091.25 AIC15326.1 - 2.9e-14 53.7 0.7 6e-13 49.4 0.7 2.2 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Pribosyltran PF00156.27 AIC15326.1 - 0.025 14.1 0.0 0.064 12.8 0.0 1.7 1 0 0 1 1 1 0 Phosphoribosyl transferase domain Radical_SAM PF04055.21 AIC15327.1 - 7e-23 81.8 0.0 1.1e-22 81.1 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily UPF0004 PF00919.20 AIC15327.1 - 3.1e-18 65.6 0.4 8e-18 64.3 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein family UPF0004 DUF4127 PF13552.6 AIC15327.1 - 0.13 10.9 0.0 0.25 9.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) Herpes_UL51 PF04540.13 AIC15328.1 - 0.017 14.9 0.1 0.037 13.8 0.0 1.6 1 1 1 2 2 2 0 Herpesvirus UL51 protein PMT_4TMC PF16192.5 AIC15330.1 - 2e-05 24.3 0.2 2.2e-05 24.1 0.2 1.1 1 0 0 1 1 1 1 C-terminal four TMM region of protein-O-mannosyltransferase ABC_membrane PF00664.23 AIC15330.1 - 0.0022 17.7 2.0 0.0025 17.5 2.0 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region GPI2 PF06432.11 AIC15330.1 - 0.045 13.2 0.3 0.05 13.0 0.3 1.0 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase PEP-utilisers_N PF05524.13 AIC15331.1 - 0.11 12.6 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 PEP-utilising enzyme, N-terminal AhpC-TSA PF00578.21 AIC15332.1 - 2.8e-24 85.4 0.0 3.6e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC15332.1 - 2.8e-18 66.1 0.0 3.3e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Redoxin GSHPx PF00255.19 AIC15332.1 - 1.6e-07 30.9 0.0 2.2e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin_2 PF13098.6 AIC15332.1 - 0.00089 19.7 0.0 0.0018 18.7 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin-like domain SCO1-SenC PF02630.14 AIC15332.1 - 0.0051 16.7 0.0 0.007 16.3 0.0 1.2 1 0 0 1 1 1 1 SCO1/SenC Thioredoxin_8 PF13905.6 AIC15332.1 - 0.028 14.8 0.0 0.039 14.3 0.0 1.3 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_3 PF13192.6 AIC15332.1 - 0.16 12.0 0.0 0.99 9.5 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin domain DAO PF01266.24 AIC15333.1 - 2.6e-08 33.9 4.7 0.00069 19.3 1.3 2.4 1 1 1 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AIC15333.1 - 3.8e-06 26.4 2.3 4.6e-05 22.8 2.3 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 AIC15333.1 - 1e-05 25.0 0.9 0.054 12.7 1.1 3.2 3 0 0 3 3 3 2 FAD binding domain FAD_binding_2 PF00890.24 AIC15333.1 - 0.00011 21.4 0.9 0.00019 20.6 0.9 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 AIC15333.1 - 0.00018 21.0 0.9 0.00027 20.4 0.9 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase HI0933_like PF03486.14 AIC15333.1 - 0.00024 20.0 5.7 0.00026 19.8 2.7 2.1 2 0 0 2 2 2 1 HI0933-like protein Thi4 PF01946.17 AIC15333.1 - 0.0015 17.8 0.2 0.0032 16.7 0.2 1.5 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 AIC15333.1 - 0.0027 17.9 1.3 0.0053 17.0 0.3 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain ETF_QO PF05187.13 AIC15333.1 - 0.012 15.7 0.6 0.093 12.9 0.5 2.3 2 0 0 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S GIDA PF01134.22 AIC15333.1 - 0.017 14.3 0.5 0.038 13.1 0.5 1.6 1 0 0 1 1 1 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 AIC15333.1 - 0.045 12.8 0.7 0.077 12.0 0.7 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein Pyr_redox PF00070.27 AIC15333.1 - 0.046 14.3 0.4 0.14 12.7 0.4 1.8 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIC15333.1 - 0.091 12.0 2.2 1.2 8.3 1.2 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 AIC15333.1 - 0.12 11.7 0.6 0.25 10.6 0.6 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Fer4 PF00037.27 AIC15333.1 - 2.5 8.1 4.5 0.68 9.9 1.2 1.8 2 0 0 2 2 2 0 4Fe-4S binding domain ETF_alpha PF00766.19 AIC15334.1 - 2.2e-25 88.5 0.1 6e-25 87.1 0.1 1.8 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain ETF PF01012.21 AIC15334.1 - 6.9e-16 58.7 0.0 5.8e-15 55.6 0.0 2.2 1 1 0 1 1 1 1 Electron transfer flavoprotein domain ETF PF01012.21 AIC15335.1 - 9.9e-26 90.7 0.1 1.4e-25 90.2 0.1 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain HD_4 PF13328.6 AIC15336.1 - 1.3e-11 44.5 0.1 2e-11 43.9 0.1 1.2 1 0 0 1 1 1 1 HD domain T3SS_needle_E PF08988.10 AIC15336.1 - 0.1 12.8 0.7 2 8.6 0.4 2.4 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle MannoseP_isomer PF01050.18 AIC15337.1 - 6.4e-23 81.3 0.0 7.1e-23 81.2 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 AIC15337.1 - 9.6e-09 34.8 0.0 1.3e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Cupin domain Pirin_C_2 PF17954.1 AIC15337.1 - 0.025 14.8 0.0 0.035 14.3 0.0 1.2 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain Ppnp PF06865.11 AIC15337.1 - 0.029 14.8 0.0 0.04 14.3 0.0 1.2 1 0 0 1 1 1 0 Pyrimidine/purine nucleoside phosphorylase CENP-C_C PF11699.8 AIC15337.1 - 0.18 12.0 0.0 0.23 11.7 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like A2L_zn_ribbon PF08792.10 AIC15338.1 - 0.25 11.1 3.0 1.6 8.5 0.2 2.7 3 0 0 3 3 3 0 A2L zinc ribbon domain HTH_20 PF12840.7 AIC15339.1 - 2.3e-15 56.4 0.2 5.1e-15 55.3 0.1 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.20 AIC15339.1 - 6.2e-12 45.2 0.1 1.8e-11 43.7 0.0 1.9 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIC15339.1 - 4e-09 35.9 0.0 9.7e-09 34.7 0.0 1.7 2 0 0 2 2 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIC15339.1 - 1.3e-07 31.3 0.0 3.5e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 AIC15339.1 - 1.3e-05 25.0 0.1 3.8e-05 23.5 0.0 1.7 2 0 0 2 2 1 1 HTH domain HTH_Crp_2 PF13545.6 AIC15339.1 - 2e-05 24.4 0.0 4.1e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_34 PF13601.6 AIC15339.1 - 0.0026 17.9 0.1 0.0046 17.1 0.1 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_12 PF08461.10 AIC15339.1 - 0.0043 17.0 0.1 0.0096 15.9 0.1 1.6 1 0 0 1 1 1 1 Ribonuclease R winged-helix domain B-block_TFIIIC PF04182.12 AIC15339.1 - 0.011 15.9 0.0 0.027 14.6 0.0 1.6 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC MarR PF01047.22 AIC15339.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.6 1 0 0 1 1 1 0 MarR family Sigma70_r4 PF04545.16 AIC15339.1 - 0.015 14.8 0.0 0.083 12.4 0.0 2.1 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_27 PF13463.6 AIC15339.1 - 0.04 14.4 0.0 0.075 13.5 0.0 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain DprA_WH PF17782.1 AIC15339.1 - 0.049 13.8 0.1 0.11 12.6 0.1 1.6 2 0 0 2 2 1 0 DprA winged helix domain FaeA PF04703.12 AIC15339.1 - 0.051 14.0 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 FaeA-like protein Sigma70_r4_2 PF08281.12 AIC15339.1 - 0.061 13.0 0.0 0.31 10.7 0.0 2.1 3 0 0 3 3 3 0 Sigma-70, region 4 HTH_10 PF04967.12 AIC15339.1 - 0.065 13.0 0.0 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 HTH DNA binding domain DUF2513 PF10711.9 AIC15339.1 - 0.071 13.4 0.1 0.22 11.8 0.0 1.7 2 0 0 2 2 2 0 Hypothetical protein (DUF2513) HTH_IclR PF09339.10 AIC15339.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 IclR helix-turn-helix domain Fe_dep_repress PF01325.19 AIC15339.1 - 0.12 12.6 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain Asn_synthase PF00733.21 AIC15341.1 - 1.1e-50 173.3 3.1 6.8e-33 114.8 0.0 2.2 1 1 1 2 2 2 2 Asparagine synthase GATase_7 PF13537.6 AIC15341.1 - 4.1e-33 113.9 0.0 7e-33 113.2 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 AIC15341.1 - 1.9e-31 109.0 0.0 3.5e-31 108.2 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain NAD_synthase PF02540.17 AIC15341.1 - 0.00061 19.0 0.0 0.006 15.7 0.1 2.2 2 0 0 2 2 2 1 NAD synthase QueC PF06508.13 AIC15341.1 - 0.0029 17.1 0.0 0.0063 16.0 0.0 1.6 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC PAPS_reduct PF01507.19 AIC15341.1 - 0.08 13.0 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family HypA PF01155.19 AIC15342.1 - 0.002 18.2 1.9 0.0021 18.0 1.9 1.0 1 0 0 1 1 1 1 Hydrogenase/urease nickel incorporation, metallochaperone, hypA C1_1 PF00130.22 AIC15342.1 - 0.0035 17.2 2.4 0.0041 17.0 2.4 1.1 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Spt4 PF06093.13 AIC15342.1 - 0.014 15.5 1.0 0.014 15.5 1.0 1.0 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger VATC PF18716.1 AIC15342.1 - 0.037 13.9 3.6 2.8 7.9 0.4 2.1 1 1 1 2 2 2 0 Vms1-associating treble clef domain Fumerase_C PF05683.12 AIC15342.1 - 0.095 12.0 0.0 0.095 12.0 0.0 1.0 1 0 0 1 1 1 0 Fumarase C-terminus zf-dskA_traR PF01258.17 AIC15342.1 - 0.4 10.7 4.8 0.73 9.8 0.9 2.1 2 0 0 2 2 2 0 Prokaryotic dksA/traR C4-type zinc finger UvrB_inter PF17757.1 AIC15343.1 - 2.2e-27 95.1 0.2 7e-27 93.4 0.0 2.0 2 0 0 2 2 2 1 UvrB interaction domain UvrB PF12344.8 AIC15343.1 - 9.1e-21 73.4 2.2 2.2e-20 72.2 2.2 1.7 1 0 0 1 1 1 1 Ultra-violet resistance protein B Helicase_C PF00271.31 AIC15343.1 - 1.2e-18 67.5 0.3 4e-18 65.8 0.3 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIC15343.1 - 6.9e-11 42.4 0.1 6.4e-10 39.3 0.1 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 AIC15343.1 - 2.1e-05 24.4 0.2 0.0009 19.0 0.0 3.0 3 0 0 3 3 3 1 DEAD/DEAH box helicase UVR PF02151.19 AIC15343.1 - 0.016 15.0 6.2 0.016 15.0 6.2 3.0 2 0 0 2 2 2 0 UvrB/uvrC motif Kinesin PF00225.23 AIC15343.1 - 0.022 13.7 0.0 0.04 12.8 0.0 1.3 1 0 0 1 1 1 0 Kinesin motor domain AAA_30 PF13604.6 AIC15343.1 - 0.023 14.4 0.0 0.17 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Tim44 PF04280.15 AIC15343.1 - 0.04 14.0 0.5 0.3 11.2 0.1 2.3 2 0 0 2 2 2 0 Tim44-like domain UB2H PF14814.6 AIC15343.1 - 0.05 13.6 0.0 0.38 10.8 0.0 2.4 2 0 0 2 2 2 0 Bifunctional transglycosylase second domain Microtub_bd PF16796.5 AIC15343.1 - 0.088 12.7 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Microtubule binding ABC_tran PF00005.27 AIC15343.1 - 0.089 13.3 0.1 0.34 11.4 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_19 PF13245.6 AIC15343.1 - 0.26 11.6 3.9 4 7.8 0.2 2.7 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 AIC15343.1 - 9.6 6.2 6.9 2 8.5 0.3 2.8 3 0 0 3 3 3 0 Helicase HerA, central domain UvrA_inter PF17760.1 AIC15344.1 - 2.8e-37 127.1 0.3 6.3e-37 126.0 0.3 1.6 1 0 0 1 1 1 1 UvrA interaction domain UvrA_DNA-bind PF17755.1 AIC15344.1 - 5.2e-37 126.6 0.1 2e-34 118.3 0.0 3.3 3 0 0 3 3 3 1 UvrA DNA-binding domain ABC_tran PF00005.27 AIC15344.1 - 2.1e-22 80.1 0.3 0.00021 21.8 0.0 4.6 4 0 0 4 4 4 4 ABC transporter SMC_N PF02463.19 AIC15344.1 - 1.5e-10 40.9 0.2 0.31 10.4 0.0 4.1 4 0 0 4 4 4 4 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AIC15344.1 - 9.4e-10 38.8 4.5 0.001 18.9 0.0 4.4 4 0 0 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AIC15344.1 - 5e-08 32.6 0.2 0.015 15.1 0.0 2.5 2 0 0 2 2 2 2 P-loop containing region of AAA domain AAA_16 PF13191.6 AIC15344.1 - 5.4e-08 33.4 0.1 0.038 14.4 0.0 3.5 4 0 0 4 4 3 2 AAA ATPase domain RsgA_GTPase PF03193.16 AIC15344.1 - 3.8e-07 30.2 0.1 0.0098 15.8 0.0 2.5 2 0 0 2 2 2 2 RsgA GTPase AAA_25 PF13481.6 AIC15344.1 - 3.4e-06 26.8 0.1 0.077 12.6 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_33 PF13671.6 AIC15344.1 - 3.5e-06 27.2 0.5 0.27 11.4 0.0 4.0 4 0 0 4 4 4 2 AAA domain AAA_23 PF13476.6 AIC15344.1 - 2.8e-05 24.7 5.5 0.0044 17.5 0.2 2.9 3 0 0 3 3 2 2 AAA domain NACHT PF05729.12 AIC15344.1 - 8.3e-05 22.6 0.0 0.14 12.1 0.0 2.6 3 0 0 3 3 2 2 NACHT domain AAA_14 PF13173.6 AIC15344.1 - 9.3e-05 22.5 0.0 0.22 11.6 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 AIC15344.1 - 0.00018 21.8 2.7 0.58 10.4 0.0 3.8 5 0 0 5 5 4 2 AAA domain AAA_18 PF13238.6 AIC15344.1 - 0.00042 20.9 1.0 1 9.9 0.0 3.1 3 0 0 3 3 2 2 AAA domain APS_kinase PF01583.20 AIC15344.1 - 0.00056 19.8 0.8 0.37 10.7 0.0 2.9 3 0 0 3 3 2 1 Adenylylsulphate kinase cobW PF02492.19 AIC15344.1 - 0.00064 19.4 0.6 0.28 10.7 0.1 2.6 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain DUF2075 PF09848.9 AIC15344.1 - 0.0014 18.0 0.2 1.5 8.0 0.2 2.3 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 AIC15344.1 - 0.0015 17.7 0.0 1.3 8.0 0.0 2.4 2 0 0 2 2 2 2 Type II/IV secretion system protein ATPase PF06745.13 AIC15344.1 - 0.0015 17.9 0.1 0.89 8.9 0.0 2.8 2 0 0 2 2 2 1 KaiC NB-ARC PF00931.22 AIC15344.1 - 0.0021 17.3 0.5 4.7 6.3 0.1 3.3 3 0 0 3 3 3 0 NB-ARC domain Viral_helicase1 PF01443.18 AIC15344.1 - 0.0026 17.6 0.1 0.33 10.6 0.1 2.8 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DnaJ_CXXCXGXG PF00684.19 AIC15344.1 - 0.0032 17.8 13.8 0.018 15.4 0.9 4.3 3 1 0 3 3 3 1 DnaJ central domain ATPase_2 PF01637.18 AIC15344.1 - 0.0069 16.3 1.2 1.7 8.5 0.0 3.1 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea MMR_HSR1 PF01926.23 AIC15344.1 - 0.0097 16.0 0.7 5 7.2 0.1 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase AAA_30 PF13604.6 AIC15344.1 - 0.01 15.6 0.4 7.2 6.3 0.1 3.0 3 0 0 3 3 2 0 AAA domain MeaB PF03308.16 AIC15344.1 - 0.012 14.6 0.3 5.5 5.9 0.1 2.9 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_15 PF13175.6 AIC15344.1 - 0.017 14.8 9.2 3.4 7.3 0.0 4.3 4 1 0 4 4 4 0 AAA ATPase domain RNA_helicase PF00910.22 AIC15344.1 - 0.02 15.3 0.1 3.3 8.1 0.0 2.7 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 AIC15344.1 - 0.021 14.7 2.0 3.5 7.5 0.1 3.2 3 0 0 3 3 2 0 NTPase AAA_28 PF13521.6 AIC15344.1 - 0.024 14.9 0.3 13 6.0 0.0 3.3 4 0 0 4 4 2 0 AAA domain BCA_ABC_TP_C PF12399.8 AIC15344.1 - 0.029 14.3 0.7 0.36 10.8 0.2 2.6 2 0 0 2 2 2 0 Branched-chain amino acid ATP-binding cassette transporter DAP3 PF10236.9 AIC15344.1 - 0.033 13.4 0.1 13 4.8 0.1 3.0 3 0 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 RACo_linker PF17650.1 AIC15344.1 - 0.057 13.3 0.0 1.4 8.8 0.0 2.9 3 0 0 3 3 3 0 RACo linker region FtsK_SpoIIIE PF01580.18 AIC15344.1 - 0.064 12.6 0.2 3.6 6.9 0.0 2.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_24 PF13479.6 AIC15344.1 - 0.075 12.8 1.4 14 5.3 0.1 3.0 3 0 0 3 3 3 0 AAA domain Zeta_toxin PF06414.12 AIC15344.1 - 0.09 12.0 0.0 4.5 6.5 0.0 2.7 2 0 0 2 2 2 0 Zeta toxin Sigma54_activat PF00158.26 AIC15344.1 - 0.14 11.9 0.1 2.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_7 PF12775.7 AIC15344.1 - 0.18 11.3 0.1 26 4.3 0.1 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region DUF87 PF01935.17 AIC15344.1 - 2 8.5 6.0 8.3 6.4 0.1 3.5 4 0 0 4 4 3 0 Helicase HerA, central domain zf-FPG_IleRS PF06827.14 AIC15344.1 - 5.4 7.0 9.1 2.8 7.9 0.2 3.7 3 0 0 3 3 3 0 Zinc finger found in FPG and IleRS UvrC_HhH_N PF08459.11 AIC15345.1 - 2.3e-42 144.5 0.0 5.1e-42 143.4 0.0 1.6 1 0 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal GIY-YIG PF01541.24 AIC15345.1 - 1.4e-10 41.3 0.1 3.5e-10 40.0 0.1 1.7 1 0 0 1 1 1 1 GIY-YIG catalytic domain UVR PF02151.19 AIC15345.1 - 0.009 15.7 1.8 0.009 15.7 1.8 1.9 2 0 0 2 2 2 1 UvrB/uvrC motif FAS_meander PF17951.1 AIC15345.1 - 0.093 12.5 0.1 0.22 11.3 0.1 1.6 1 0 0 1 1 1 0 Fatty acid synthase meander beta sheet domain gpW PF02831.15 AIC15346.1 - 0.049 13.5 0.1 0.055 13.4 0.1 1.2 1 0 0 1 1 1 0 gpW DUF4318 PF14201.6 AIC15347.1 - 0.14 12.6 0.0 6.4 7.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4318) AlaDh_PNT_N PF05222.15 AIC15348.1 - 6.4e-37 126.9 0.0 1.2e-36 126.0 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain AlaDh_PNT_C PF01262.21 AIC15348.1 - 2e-22 79.6 0.3 5.5e-22 78.1 0.3 1.6 1 1 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 AIC15348.1 - 4.7e-05 22.3 0.2 6.6e-05 21.8 0.2 1.1 1 0 0 1 1 1 1 HI0933-like protein NAD_binding_7 PF13241.6 AIC15348.1 - 0.0011 19.4 0.1 0.0024 18.3 0.1 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 AIC15348.1 - 0.0029 17.7 0.1 0.0067 16.5 0.1 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ADH_zinc_N PF00107.26 AIC15348.1 - 0.0048 16.9 0.3 0.012 15.6 0.3 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase FAD_binding_3 PF01494.19 AIC15348.1 - 0.0089 15.3 0.1 0.019 14.2 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain 2-Hacid_dh_C PF02826.19 AIC15348.1 - 0.01 15.2 0.1 0.019 14.3 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox PF00070.27 AIC15348.1 - 0.023 15.3 0.0 0.059 13.9 0.0 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase UDPG_MGDP_dh_C PF03720.15 AIC15348.1 - 0.036 14.5 0.1 0.085 13.3 0.1 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain XdhC_C PF13478.6 AIC15348.1 - 0.039 14.5 0.3 0.089 13.3 0.0 1.7 2 0 0 2 2 2 0 XdhC Rossmann domain Trp_halogenase PF04820.14 AIC15348.1 - 0.11 11.3 0.3 0.21 10.4 0.1 1.5 2 0 0 2 2 2 0 Tryptophan halogenase Copper-bind PF00127.20 AIC15350.1 - 2e-10 41.0 0.0 2.7e-10 40.5 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC15350.1 - 6.1e-05 23.1 0.0 0.00019 21.5 0.0 1.8 1 1 0 1 1 1 1 Cupredoxin-like domain BTRD1 PF17660.1 AIC15353.1 - 1.7e-10 40.5 6.2 0.12 12.3 0.0 5.5 5 0 0 5 5 5 4 Bacterial tandem repeat domain 1 Peptidase_M23 PF01551.22 AIC15353.1 - 3.3e-07 30.4 0.5 6.4e-06 26.3 0.4 2.4 2 0 0 2 2 2 1 Peptidase family M23 Cupredoxin_1 PF13473.6 AIC15354.1 - 3.7e-13 49.5 0.0 6.5e-13 48.7 0.0 1.4 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIC15354.1 - 1.3e-09 38.4 0.2 1.1e-08 35.4 0.2 2.1 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family HTH_45 PF14947.6 AIC15355.1 - 2.6e-05 24.1 0.0 3.1e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIC15355.1 - 0.0073 16.2 0.0 0.011 15.6 0.0 1.3 1 0 0 1 1 1 1 MarR family DUF1495 PF07381.11 AIC15355.1 - 0.045 13.6 0.0 0.06 13.2 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) DUF2721 PF11026.8 AIC15356.1 - 0.00072 19.4 0.6 0.0021 17.9 0.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2721) DUF2207 PF09972.9 AIC15356.1 - 0.003 16.4 0.0 0.003 16.4 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF4231 PF14015.6 AIC15356.1 - 0.066 13.7 0.6 0.089 13.3 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) DUF2852 PF11014.8 AIC15356.1 - 1.2 9.4 5.4 9.2 6.4 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2852) PrgI PF12666.7 AIC15356.1 - 1.2 9.9 5.2 2.2 9.0 5.2 1.4 1 1 0 1 1 1 0 PrgI family protein CbiQ PF02361.16 AIC15356.1 - 4.4 6.9 7.7 63 3.1 7.7 2.0 1 1 0 1 1 1 0 Cobalt transport protein Radical_SAM PF04055.21 AIC15359.1 - 2.2e-15 57.4 0.0 3.9e-15 56.6 0.0 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AIC15359.1 - 0.15 12.2 0.0 0.34 11.0 0.0 1.6 1 0 0 1 1 1 0 4Fe-4S single cluster domain Big_1 PF02369.16 AIC15359.1 - 0.18 11.9 1.3 0.59 10.2 0.1 2.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 1) Radical_SAM PF04055.21 AIC15360.1 - 1e-09 39.0 0.0 1.9e-09 38.1 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Trypsin_2 PF13365.6 AIC15361.1 - 1.3e-32 113.8 0.1 2.7e-32 112.8 0.1 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 AIC15361.1 - 2e-14 53.7 4.5 3.1e-13 49.8 2.3 2.9 2 1 0 2 2 2 1 PDZ domain Trypsin PF00089.26 AIC15361.1 - 1.5e-12 47.8 0.0 2.8e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 AIC15361.1 - 1e-06 28.5 5.2 0.0012 18.6 0.2 3.2 3 1 1 4 4 4 2 PDZ domain PDZ PF00595.24 AIC15361.1 - 0.0006 20.1 1.3 0.05 14.0 0.0 3.3 3 0 0 3 3 3 1 PDZ domain Peptidase_S29 PF02907.15 AIC15361.1 - 0.049 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Peptidase_S7 PF00949.21 AIC15361.1 - 0.093 12.6 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase S7, Flavivirus NS3 serine protease HTH_45 PF14947.6 AIC15362.1 - 9e-18 64.0 0.2 1.1e-17 63.8 0.2 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC15362.1 - 5e-05 23.1 0.1 6.1e-05 22.8 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_27 PF13463.6 AIC15362.1 - 0.00086 19.8 0.1 0.0013 19.2 0.1 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 AIC15362.1 - 0.037 13.8 0.1 0.054 13.3 0.1 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain DUF1495 PF07381.11 AIC15362.1 - 0.094 12.6 0.1 0.19 11.6 0.1 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) RQC PF09382.10 AIC15362.1 - 0.12 12.2 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 RQC domain Glycos_transf_2 PF00535.26 AIC15363.1 - 6.2e-29 101.0 0.0 9.3e-29 100.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIC15363.1 - 4.1e-22 79.2 0.0 5.7e-22 78.7 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 AIC15363.1 - 2.1e-13 50.1 0.0 4.6e-13 49.0 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIC15363.1 - 1.9e-10 40.7 0.0 2.6e-10 40.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIC15363.1 - 0.0001 22.8 0.0 0.00018 22.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 FAD_binding_3 PF01494.19 AIC15363.1 - 0.25 10.5 0.7 1.1 8.4 0.0 2.0 2 0 0 2 2 2 0 FAD binding domain Polyketide_cyc2 PF10604.9 AIC15364.1 - 7.9e-13 48.9 0.1 8.6e-13 48.8 0.1 1.0 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIC15364.1 - 5.5e-08 33.1 0.0 7.9e-08 32.6 0.0 1.3 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport COXG PF06240.13 AIC15364.1 - 0.042 13.6 0.1 0.059 13.1 0.1 1.2 1 0 0 1 1 1 0 Carbon monoxide dehydrogenase subunit G (CoxG) CbtA PF09490.10 AIC15365.1 - 9e-51 173.0 18.5 1e-50 172.8 18.5 1.0 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) 7tm_3 PF00003.22 AIC15365.1 - 0.12 12.1 2.3 0.13 12.0 0.3 2.0 1 1 1 2 2 2 0 7 transmembrane sweet-taste receptor of 3 GCPR DUF1427 PF07235.11 AIC15365.1 - 1.3 9.0 7.6 1.9 8.5 0.4 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1427) 7TM-7TMR_HD PF07698.11 AIC15365.1 - 1.5 8.5 10.9 0.21 11.3 1.1 2.8 2 1 1 3 3 3 0 7TM receptor with intracellular HD hydrolase CbtB PF09489.10 AIC15366.1 - 7.4e-13 48.4 0.7 9.9e-13 48.0 0.7 1.2 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtB) DUF4443 PF14544.6 AIC15367.1 - 0.00038 20.7 0.0 0.00059 20.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4443) MarR_2 PF12802.7 AIC15367.1 - 0.091 12.7 0.0 0.23 11.4 0.0 1.7 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 AIC15367.1 - 0.14 11.8 0.1 0.42 10.2 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding FeoC PF09012.10 AIC15367.1 - 0.16 12.0 0.5 0.51 10.4 0.2 1.9 2 0 0 2 2 2 0 FeoC like transcriptional regulator Yae1_N PF09811.9 AIC15368.1 - 0.9 9.3 8.3 18 5.2 0.5 3.1 2 1 0 2 2 2 0 Essential protein Yae1, N terminal Guanylate_cyc PF00211.20 AIC15370.1 - 8.1e-15 54.9 0.1 1.1e-14 54.5 0.1 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3445 PF11927.8 AIC15370.1 - 0.17 11.5 0.0 0.34 10.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3445) CBS PF00571.28 AIC15371.1 - 1.3e-23 83.2 0.4 7.7e-14 51.9 0.0 2.1 2 0 0 2 2 2 2 CBS domain Hs1pro-1_N PF07231.12 AIC15371.1 - 0.016 14.9 0.0 0.023 14.5 0.0 1.1 1 0 0 1 1 1 0 Hs1pro-1 N-terminus RDD PF06271.12 AIC15372.1 - 5.1e-18 65.6 5.4 6.3e-18 65.3 5.4 1.1 1 0 0 1 1 1 1 RDD family F5_F8_type_C PF00754.25 AIC15373.1 - 1.4e-18 67.2 0.2 2.4e-18 66.5 0.2 1.3 1 0 0 1 1 1 1 F5/8 type C domain LysM PF01476.20 AIC15373.1 - 1.7e-13 50.4 0.0 2.8e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 LysM domain 3D PF06725.11 AIC15373.1 - 4.8e-05 23.5 0.0 0.00012 22.2 0.0 1.7 1 0 0 1 1 1 1 3D domain HTH_27 PF13463.6 AIC15374.1 - 0.0012 19.3 0.3 0.029 14.8 0.1 2.3 2 0 0 2 2 2 1 Winged helix DNA-binding domain Dynamitin PF04912.14 AIC15374.1 - 0.0061 15.9 0.1 0.0075 15.6 0.1 1.1 1 0 0 1 1 1 1 Dynamitin Dynactin_p22 PF07426.11 AIC15374.1 - 0.012 15.5 0.1 0.016 15.1 0.1 1.2 1 0 0 1 1 1 0 Dynactin subunit p22 Fibritin_C PF07921.12 AIC15374.1 - 0.02 15.0 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 Fibritin C-terminal region FlgT_M PF16539.5 AIC15374.1 - 0.051 13.7 0.1 0.066 13.4 0.1 1.1 1 0 0 1 1 1 0 Flagellar assembly protein T, middle domain PufQ PF05398.11 AIC15376.1 - 0.054 13.6 0.3 0.059 13.5 0.3 1.2 1 0 0 1 1 1 0 PufQ cytochrome subunit LOH1CR12 PF10158.9 AIC15379.1 - 0.1 12.6 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 Tumour suppressor protein DUF624 PF04854.14 AIC15380.1 - 0.016 15.3 0.5 0.6 10.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF624 Annexin PF00191.20 AIC15380.1 - 0.037 14.1 0.3 0.083 13.0 0.3 1.6 1 0 0 1 1 1 0 Annexin TENA_THI-4 PF03070.16 AIC15381.1 - 2.2e-16 60.3 0.8 2.7e-16 60.0 0.8 1.1 1 0 0 1 1 1 1 TENA/THI-4/PQQC family Haem_oxygenas_2 PF14518.6 AIC15381.1 - 1.2e-14 54.5 0.2 1.5e-14 54.2 0.2 1.1 1 0 0 1 1 1 1 Iron-containing redox enzyme HTH_45 PF14947.6 AIC15383.1 - 1e-19 70.3 0.1 1.4e-19 69.8 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC15383.1 - 0.00016 21.4 0.1 0.00024 20.9 0.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4364) DUF3927 PF13064.6 AIC15383.1 - 0.15 12.1 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3927) NitrOD2 PF18550.1 AIC15384.1 - 9.3e-52 173.5 0.9 1e-51 173.4 0.9 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 Pol_alpha_B_N PF08418.10 AIC15385.1 - 0.035 14.1 0.1 0.035 14.1 0.1 1.0 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal LEM PF03020.15 AIC15385.1 - 0.07 12.7 0.0 0.17 11.5 0.0 1.7 2 0 0 2 2 2 0 LEM domain DUF4834 PF16118.5 AIC15386.1 - 0.66 11.0 9.6 5.4 8.0 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4834) AmoC PF04896.12 AIC15387.1 - 1e-12 47.9 6.2 1.2e-12 47.6 6.2 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 AIC15387.1 - 0.014 15.0 0.2 0.023 14.3 0.2 1.2 1 0 0 1 1 1 0 RTA1 like protein polyprenyl_synt PF00348.17 AIC15388.1 - 1.4e-52 178.3 0.0 2e-52 177.8 0.0 1.1 1 0 0 1 1 1 1 Polyprenyl synthetase Proton_antipo_M PF00361.20 AIC15389.1 - 4.1e-66 223.2 23.1 4.1e-66 223.2 23.1 2.4 2 1 0 2 2 2 1 Proton-conducting membrane transporter DUF2108 PF09881.9 AIC15389.1 - 0.34 10.9 7.7 0.041 13.9 1.7 2.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2108) Proton_antipo_M PF00361.20 AIC15390.1 - 5.9e-63 212.8 40.0 1.1e-62 211.9 32.3 2.8 2 1 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIC15390.1 - 7.6e-11 41.9 1.6 7.6e-11 41.9 1.6 3.0 2 0 0 2 2 2 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Proton_antipo_C PF01010.19 AIC15390.1 - 0.00063 19.4 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Proton_antipo_M PF00361.20 AIC15391.1 - 8e-66 222.2 27.1 8e-66 222.2 27.1 2.0 2 0 0 2 2 2 1 Proton-conducting membrane transporter Proton_antipo_N PF00662.20 AIC15391.1 - 0.0014 18.7 0.0 0.0014 18.7 0.0 3.6 4 0 0 4 4 4 1 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus Oxidored_q2 PF00420.24 AIC15392.1 - 5.3e-25 87.1 8.0 6.2e-25 86.9 8.0 1.0 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF3918 PF13056.6 AIC15392.1 - 0.072 12.7 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3918) Proton_antipo_C PF01010.19 AIC15392.1 - 0.087 12.4 1.9 0.094 12.3 1.9 1.0 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus DUF3098 PF11297.8 AIC15392.1 - 0.83 9.3 9.8 0.18 11.5 3.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3098) DUF4418 PF14387.6 AIC15392.1 - 4.8 7.4 10.8 13 6.0 8.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4418) Oxidored_q3 PF00499.20 AIC15393.1 - 4.5e-24 84.8 18.4 5.7e-24 84.5 18.4 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4040 PF13244.6 AIC15393.1 - 0.00098 19.2 13.7 0.00098 19.2 13.7 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4040) TMEM171 PF15471.6 AIC15393.1 - 0.08 11.9 0.2 0.14 11.1 0.0 1.5 1 1 0 1 1 1 0 Transmembrane protein family 171 Fer4 PF00037.27 AIC15394.1 - 4.3e-13 48.5 11.0 3.4e-09 36.1 1.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 AIC15394.1 - 6.2e-10 39.1 17.6 2.4e-06 27.6 11.0 1.8 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_7 PF12838.7 AIC15394.1 - 2.2e-09 37.7 6.3 3.9e-09 36.9 6.3 1.5 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIC15394.1 - 4.1e-07 29.8 11.9 4.4e-05 23.4 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 AIC15394.1 - 5.9e-07 29.5 10.0 1.5e-06 28.2 10.1 1.6 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIC15394.1 - 6.5e-07 29.7 1.6 0.003 18.0 0.1 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIC15394.1 - 1.2e-06 28.6 8.6 4.7e-06 26.7 9.3 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 AIC15394.1 - 2.4e-06 27.6 7.5 0.012 16.1 0.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_2 PF12797.7 AIC15394.1 - 1.4e-05 24.8 10.9 0.0016 18.4 1.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIC15394.1 - 0.00022 21.9 4.4 0.12 13.1 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain Fer4_16 PF13484.6 AIC15394.1 - 0.00074 20.4 10.0 0.01 16.8 0.3 2.3 1 1 2 3 3 3 2 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 AIC15394.1 - 0.00081 19.9 9.4 0.053 14.1 0.7 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_13 PF13370.6 AIC15394.1 - 0.0029 18.1 4.9 0.24 12.0 0.1 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_3 PF12798.7 AIC15394.1 - 0.011 16.6 4.1 0.011 16.6 4.1 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_18 PF13746.6 AIC15394.1 - 0.11 12.8 10.4 0.36 11.0 1.7 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_22 PF17179.4 AIC15394.1 - 0.29 12.0 0.5 0.29 12.0 0.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain NADHdh PF00146.21 AIC15395.1 - 7.3e-93 311.1 22.2 7.3e-93 311.1 22.2 1.4 2 0 0 2 2 2 1 NADH dehydrogenase NDUF_B12 PF08122.12 AIC15395.1 - 1.1 9.3 5.5 0.14 12.2 0.5 2.1 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase B12 subunit family Complex1_49kDa PF00346.19 AIC15396.1 - 1.1e-80 270.7 0.0 6.4e-60 202.5 0.0 2.2 1 1 1 2 2 2 2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit Csm1 PF12539.8 AIC15396.1 - 0.087 13.5 0.0 22 5.8 0.0 2.8 3 0 0 3 3 3 0 Chromosome segregation protein Csm1/Pcs1 Complex1_30kDa PF00329.19 AIC15397.1 - 3.5e-32 111.6 0.0 4.5e-32 111.2 0.0 1.1 1 0 0 1 1 1 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit CCDC53 PF10152.9 AIC15397.1 - 8.3 6.8 6.4 15 6.0 6.4 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Oxidored_q6 PF01058.22 AIC15398.1 - 4.9e-24 84.6 0.4 7e-24 84.1 0.4 1.2 1 0 0 1 1 1 1 NADH ubiquinone oxidoreductase, 20 Kd subunit Oxidored_q4 PF00507.19 AIC15399.1 - 1.3e-18 66.9 0.9 1.8e-18 66.5 0.9 1.1 1 0 0 1 1 1 1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 DUF4367 PF14285.6 AIC15400.1 - 7.9e-05 23.1 0.0 0.00031 21.2 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4367) FAD_oxidored PF12831.7 AIC15403.1 - 2.7e-14 53.3 0.3 3.7e-14 52.9 0.3 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO PF01266.24 AIC15403.1 - 4.2e-10 39.7 5.0 1.6e-06 28.0 2.3 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 AIC15403.1 - 2.6e-09 36.6 0.2 5.5e-09 35.6 0.0 1.6 2 0 0 2 2 2 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 AIC15403.1 - 6.9e-09 35.4 0.1 1.3e-08 34.5 0.1 1.7 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 AIC15403.1 - 2.7e-08 32.9 0.9 4.1e-08 32.4 0.4 1.5 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 AIC15403.1 - 3e-07 30.6 0.1 8.1e-07 29.2 0.1 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 AIC15403.1 - 3.2e-07 29.8 2.1 3.2e-07 29.8 2.1 1.9 2 0 0 2 2 2 1 FAD binding domain GIDA PF01134.22 AIC15403.1 - 5.1e-07 29.1 1.1 7.4e-07 28.6 1.1 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Trp_halogenase PF04820.14 AIC15403.1 - 2.6e-06 26.6 1.2 0.04 12.8 0.6 2.4 1 1 1 2 2 2 2 Tryptophan halogenase Pyr_redox_2 PF07992.14 AIC15403.1 - 6.4e-06 25.6 1.3 1.7e-05 24.2 0.4 1.8 1 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 AIC15403.1 - 9.9e-06 25.0 0.1 1.5e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 AIC15403.1 - 9.6e-05 21.8 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 AIC15403.1 - 0.0012 18.1 0.8 0.0024 17.2 0.1 1.7 2 0 0 2 2 2 1 Thi4 family Pyr_redox PF00070.27 AIC15403.1 - 0.022 15.3 1.0 0.052 14.1 0.2 2.0 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 AIC15403.1 - 0.023 14.6 1.0 0.047 13.6 0.2 1.9 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain PmbA_TldD PF01523.16 AIC15404.1 - 2.3e-52 178.6 5.8 2.8e-52 178.3 5.8 1.1 1 0 0 1 1 1 1 Putative modulator of DNA gyrase PmbA_TldD PF01523.16 AIC15405.1 - 3.1e-58 197.8 5.2 5.1e-58 197.1 5.2 1.3 1 0 0 1 1 1 1 Putative modulator of DNA gyrase GSDH PF07995.11 AIC15406.1 - 2.6e-46 158.5 0.0 8e-46 156.9 0.0 1.7 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase PQQ PF01011.21 AIC15406.1 - 0.31 11.1 4.0 49 4.1 0.1 4.1 4 0 0 4 4 4 0 PQQ enzyme repeat Cupin_2 PF07883.11 AIC15407.1 - 1e-08 34.7 0.6 1.4e-07 31.1 0.6 2.1 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 AIC15407.1 - 3.5e-05 23.5 0.0 4.5e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 Cupin Auxin_BP PF02041.16 AIC15407.1 - 0.00037 20.2 0.0 0.00042 20.0 0.0 1.2 1 0 0 1 1 1 1 Auxin binding protein ARD PF03079.14 AIC15407.1 - 0.0057 16.9 0.1 0.0077 16.4 0.1 1.3 1 0 0 1 1 1 1 ARD/ARD' family AraC_binding PF02311.19 AIC15407.1 - 0.034 14.0 0.3 0.062 13.2 0.3 1.4 1 1 0 1 1 1 0 AraC-like ligand binding domain DUF620 PF04788.12 AIC15407.1 - 0.08 12.3 0.1 0.099 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF620) Ins145_P3_rec PF08709.11 AIC15407.1 - 0.13 11.4 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor adh_short PF00106.25 AIC15408.1 - 7.4e-58 195.2 0.8 9.2e-58 194.9 0.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIC15408.1 - 1.5e-47 162.2 0.2 2.1e-47 161.7 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIC15408.1 - 1.6e-13 50.9 0.7 2e-13 50.6 0.7 1.1 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 AIC15408.1 - 0.00051 20.3 0.6 0.0012 19.1 0.6 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain DUF1776 PF08643.10 AIC15408.1 - 0.017 14.5 0.0 0.042 13.2 0.0 1.6 2 0 0 2 2 2 0 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 AIC15408.1 - 0.021 14.3 0.1 0.026 14.0 0.1 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 AIC15408.1 - 0.034 13.5 0.5 0.066 12.5 0.2 1.6 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 2-Hacid_dh_C PF02826.19 AIC15408.1 - 0.069 12.5 0.4 0.43 9.9 0.1 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Thioredoxin_10 PF17991.1 AIC15409.1 - 2e-13 51.1 0.0 3.1e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin like C-terminal domain AhpC-TSA PF00578.21 AIC15409.1 - 1.2e-10 41.4 0.0 2e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC15409.1 - 5.4e-08 32.7 0.0 7.4e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 AIC15409.1 - 8.5e-07 29.2 0.0 2.6e-06 27.6 0.0 1.8 2 0 0 2 2 2 1 Thioredoxin-like GSHPx PF00255.19 AIC15409.1 - 0.044 13.3 0.0 0.073 12.6 0.0 1.3 1 0 0 1 1 1 0 Glutathione peroxidase AhpC-TSA PF00578.21 AIC15410.1 - 1.3e-38 131.7 0.0 1.6e-38 131.4 0.0 1.0 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC15410.1 - 9.4e-25 87.0 0.0 1.1e-24 86.8 0.0 1.0 1 0 0 1 1 1 1 Redoxin AhpC-TSA_2 PF13911.6 AIC15410.1 - 4.3e-07 30.1 0.0 8.2e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme DUF899 PF05988.12 AIC15410.1 - 0.00014 21.4 0.0 0.00016 21.3 0.0 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) SCO1-SenC PF02630.14 AIC15410.1 - 0.0098 15.8 0.0 0.025 14.5 0.0 1.6 1 1 0 1 1 1 1 SCO1/SenC Rubrerythrin PF02915.17 AIC15411.1 - 0.0006 20.2 2.4 0.0044 17.4 2.4 2.1 1 1 0 1 1 1 1 Rubrerythrin Ferritin PF00210.24 AIC15411.1 - 0.0023 17.9 2.7 0.012 15.5 2.5 2.1 1 1 0 1 1 1 1 Ferritin-like domain Kinase-PPPase PF03618.14 AIC15411.1 - 0.017 14.9 0.1 0.02 14.7 0.1 1.2 1 0 0 1 1 1 0 Kinase/pyrophosphorylase LPD3 PF18798.1 AIC15411.1 - 0.038 14.2 0.7 1.4 9.1 0.6 2.4 1 1 0 1 1 1 0 Large polyvalent protein-associated domain 3 Herpes_V23 PF01802.17 AIC15411.1 - 0.04 13.3 0.1 0.044 13.2 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein Phenol_Hydrox PF02332.18 AIC15411.1 - 0.047 13.2 0.1 6.1 6.3 0.0 2.1 2 0 0 2 2 2 0 Methane/Phenol/Toluene Hydroxylase FA_desaturase_2 PF03405.14 AIC15411.1 - 0.053 12.4 0.9 0.13 11.0 0.8 1.6 1 1 0 1 1 1 0 Fatty acid desaturase RNA_pol_N PF01194.17 AIC15412.1 - 1.3e-27 95.9 0.3 1.9e-27 95.3 0.3 1.3 1 0 0 1 1 1 1 RNA polymerases N / 8 kDa subunit Enolase_C PF00113.22 AIC15413.1 - 2.8e-60 204.1 0.0 3.8e-60 203.6 0.0 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 AIC15413.1 - 2.6e-26 92.3 0.2 7.8e-26 90.8 0.1 1.9 2 0 0 2 2 2 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 AIC15413.1 - 6e-10 39.1 0.0 1.6e-09 37.7 0.0 1.6 1 1 1 2 2 2 1 Enolase C-terminal domain-like 5_3_exonuc_N PF02739.16 AIC15413.1 - 0.054 13.4 0.1 0.11 12.5 0.1 1.4 1 0 0 1 1 1 0 5'-3' exonuclease, N-terminal resolvase-like domain Ribosomal_S2 PF00318.20 AIC15414.1 - 8.3e-20 70.9 0.0 3e-12 46.2 0.2 2.1 2 0 0 2 2 2 2 Ribosomal protein S2 Peripla_BP_4 PF13407.6 AIC15414.1 - 0.022 14.4 0.3 0.032 13.8 0.3 1.3 1 0 0 1 1 1 0 Periplasmic binding protein domain MEDS PF14417.6 AIC15415.1 - 0.00055 19.8 0.0 0.00061 19.6 0.0 1.1 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Med3 PF11593.8 AIC15415.1 - 0.098 11.8 1.9 0.096 11.9 1.9 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Prismane PF03063.20 AIC15415.1 - 0.13 10.9 0.0 0.13 10.9 0.0 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family MEDS PF14417.6 AIC15416.1 - 0.00062 19.6 0.0 0.0038 17.1 0.0 2.2 2 1 1 3 3 3 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Memo PF01875.17 AIC15417.1 - 2.2e-75 253.3 0.0 2.6e-75 253.1 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein MBG_2 PF18676.1 AIC15417.1 - 0.027 15.1 0.6 2 9.1 0.0 2.5 2 0 0 2 2 2 0 MBG domain (YGX type) GHMP_kinases_C PF08544.13 AIC15418.1 - 3.2e-17 62.7 1.8 3.2e-17 62.7 1.8 2.5 3 1 0 3 3 3 1 GHMP kinases C terminal GHMP_kinases_N PF00288.26 AIC15418.1 - 6.4e-17 61.5 0.4 6.4e-17 61.5 0.4 2.1 2 0 0 2 2 2 1 GHMP kinases N terminal domain PhoU PF01895.19 AIC15419.1 - 3.6e-17 62.6 5.8 2.2e-09 37.6 2.3 2.4 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 AIC15419.1 - 0.004 17.1 0.1 0.011 15.7 0.1 1.8 1 1 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin Exo70 PF03081.15 AIC15419.1 - 0.067 12.2 0.2 0.43 9.6 0.1 2.0 2 0 0 2 2 2 0 Exo70 exocyst complex subunit GHMP_kinases_N PF00288.26 AIC15420.1 - 2.9e-09 37.0 1.6 5.8e-09 36.1 1.6 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain PPS_PS PF02006.16 AIC15421.1 - 2.8e-73 245.2 0.3 3.8e-73 244.8 0.3 1.1 1 0 0 1 1 1 1 Phosphopantothenate/pantothenate synthetase Phage_GPD PF05954.11 AIC15421.1 - 0.16 11.2 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 Phage late control gene D protein (GPD) Pantoate_transf PF02548.15 AIC15422.1 - 4.7e-110 367.0 0.6 5.4e-110 366.8 0.6 1.0 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase PEP_mutase PF13714.6 AIC15422.1 - 0.00036 20.1 0.7 0.015 14.7 0.1 2.5 1 1 2 3 3 3 2 Phosphoenolpyruvate phosphomutase DFP PF04127.15 AIC15423.1 - 6.6e-56 189.1 8.6 4.6e-55 186.3 4.8 2.2 2 0 0 2 2 2 2 DNA / pantothenate metabolism flavoprotein Flavoprotein PF02441.19 AIC15423.1 - 5.2e-36 123.8 2.5 5.8e-36 123.6 1.2 1.8 2 0 0 2 2 2 1 Flavoprotein YjeF_N PF03853.15 AIC15423.1 - 7.9e-05 22.6 1.7 0.36 10.7 0.2 3.2 2 1 2 4 4 4 2 YjeF-related protein N-terminus Epimerase PF01370.21 AIC15423.1 - 0.032 13.7 0.1 0.16 11.4 0.1 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family GbpC PF08363.10 AIC15424.1 - 0.0035 16.8 0.1 0.0057 16.1 0.1 1.2 1 0 0 1 1 1 1 Glucan-binding protein C CcmE PF03100.15 AIC15424.1 - 0.11 12.5 1.3 0.35 10.9 0.0 2.1 2 0 0 2 2 2 0 CcmE Peptidase_M24 PF00557.24 AIC15425.1 - 2.3e-57 194.1 0.1 3e-57 193.7 0.1 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Creatinase_N PF01321.18 AIC15425.1 - 3.2e-10 40.8 0.1 7.5e-10 39.6 0.0 1.7 2 0 0 2 2 2 1 Creatinase/Prolidase N-terminal domain AAA PF00004.29 AIC15426.1 - 8.3e-98 323.9 0.0 3.6e-48 163.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AIC15426.1 - 4.2e-27 93.7 2.9 6.3e-14 51.5 0.1 3.0 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AIC15426.1 - 1.6e-22 79.5 0.4 4.6e-22 78.0 0.4 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain RuvB_N PF05496.12 AIC15426.1 - 3.8e-15 56.0 0.0 6.6e-08 32.4 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIC15426.1 - 8.5e-15 55.5 1.5 8.6e-05 23.0 0.0 5.3 4 2 1 5 5 4 2 AAA ATPase domain AAA_2 PF07724.14 AIC15426.1 - 2.8e-14 53.6 0.0 1.1e-05 25.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) CDC48_2 PF02933.17 AIC15426.1 - 6.6e-14 51.5 0.1 1.8e-13 50.0 0.1 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_22 PF13401.6 AIC15426.1 - 2.5e-11 44.0 0.6 0.0059 16.9 0.0 4.0 2 2 2 4 4 4 2 AAA domain AAA_5 PF07728.14 AIC15426.1 - 6.6e-10 39.1 1.1 0.0021 18.0 0.1 4.0 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 AIC15426.1 - 4.5e-09 36.6 0.0 0.00022 21.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_14 PF13173.6 AIC15426.1 - 4.9e-09 36.3 0.0 0.00094 19.2 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AIC15426.1 - 9.6e-09 34.9 0.0 0.0031 16.8 0.0 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_18 PF13238.6 AIC15426.1 - 3.6e-08 34.0 0.0 0.0036 17.9 0.0 2.7 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AIC15426.1 - 1.7e-07 31.2 0.0 0.009 15.8 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_25 PF13481.6 AIC15426.1 - 1.3e-06 28.1 0.4 1.8 8.1 0.1 3.9 3 0 0 3 3 3 3 AAA domain RNA_helicase PF00910.22 AIC15426.1 - 2.3e-06 27.9 0.1 0.071 13.5 0.0 2.9 3 0 0 3 3 2 2 RNA helicase Mg_chelatase PF01078.21 AIC15426.1 - 3e-06 26.8 0.7 0.063 12.7 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AIC15426.1 - 4.4e-06 27.0 0.0 0.011 16.0 0.0 2.6 2 0 0 2 2 2 2 AAA domain Zeta_toxin PF06414.12 AIC15426.1 - 4.7e-06 26.0 0.1 0.11 11.8 0.0 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_24 PF13479.6 AIC15426.1 - 1e-05 25.4 0.0 0.036 13.8 0.0 2.9 3 0 0 3 3 2 2 AAA domain AAA_7 PF12775.7 AIC15426.1 - 1.6e-05 24.5 0.0 0.13 11.7 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region Sigma54_activat PF00158.26 AIC15426.1 - 1.7e-05 24.6 0.0 0.41 10.3 0.0 3.6 3 1 0 3 3 2 2 Sigma-54 interaction domain TsaE PF02367.17 AIC15426.1 - 3e-05 24.0 0.0 0.19 11.8 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2075 PF09848.9 AIC15426.1 - 4.9e-05 22.7 0.2 0.057 12.7 0.0 2.4 3 0 0 3 3 2 2 Uncharacterized conserved protein (DUF2075) PhoH PF02562.16 AIC15426.1 - 5.9e-05 22.6 1.1 0.25 10.7 0.1 2.9 3 0 0 3 3 3 2 PhoH-like protein ATPase_2 PF01637.18 AIC15426.1 - 7.3e-05 22.8 0.0 0.47 10.3 0.0 2.9 2 1 1 3 3 3 2 ATPase domain predominantly from Archaea Vps4_C PF09336.10 AIC15426.1 - 7.6e-05 22.6 1.1 0.51 10.4 0.1 2.7 2 0 0 2 2 2 2 Vps4 C terminal oligomerisation domain NB-ARC PF00931.22 AIC15426.1 - 8.9e-05 21.8 0.0 0.2 10.8 0.0 2.5 2 0 0 2 2 2 2 NB-ARC domain AAA_3 PF07726.11 AIC15426.1 - 0.0001 22.1 0.0 0.34 10.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 AIC15426.1 - 0.00015 21.0 0.0 0.22 10.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ABC_tran PF00005.27 AIC15426.1 - 0.00019 22.0 0.0 0.44 11.0 0.0 2.5 2 0 0 2 2 2 1 ABC transporter NACHT PF05729.12 AIC15426.1 - 0.00024 21.1 0.0 0.27 11.2 0.0 3.1 3 0 0 3 3 3 1 NACHT domain AAA_30 PF13604.6 AIC15426.1 - 0.00026 20.8 1.6 0.22 11.2 0.0 3.0 3 0 0 3 3 2 2 AAA domain ATPase PF06745.13 AIC15426.1 - 0.00027 20.4 0.0 1.8 7.8 0.0 3.4 3 0 0 3 3 3 1 KaiC AAA_11 PF13086.6 AIC15426.1 - 0.00029 20.7 0.4 0.32 10.8 0.0 2.7 3 0 0 3 3 3 1 AAA domain NTPase_1 PF03266.15 AIC15426.1 - 0.0014 18.6 0.3 0.73 9.7 0.0 3.1 2 1 1 3 3 3 1 NTPase Parvo_NS1 PF01057.17 AIC15426.1 - 0.0015 17.7 0.1 1.2 8.2 0.0 2.3 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 TniB PF05621.11 AIC15426.1 - 0.0016 17.9 0.1 3.9 6.8 0.0 4.0 3 1 1 4 4 4 0 Bacterial TniB protein AAA_19 PF13245.6 AIC15426.1 - 0.0017 18.7 0.8 3.1 8.1 0.0 2.9 3 0 0 3 3 2 1 AAA domain Bac_DnaA PF00308.18 AIC15426.1 - 0.0018 18.2 0.0 3.4 7.4 0.0 3.0 3 0 0 3 3 3 0 Bacterial dnaA protein AAA_17 PF13207.6 AIC15426.1 - 0.0022 18.4 0.0 2.5 8.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain AFG1_ATPase PF03969.16 AIC15426.1 - 0.0031 16.5 0.0 2.2 7.1 0.0 2.4 2 0 0 2 2 2 2 AFG1-like ATPase Viral_helicase1 PF01443.18 AIC15426.1 - 0.0081 15.9 0.0 1.2 8.9 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase UFD1 PF03152.14 AIC15426.1 - 0.024 14.1 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 Cytidylate_kin PF02224.18 AIC15426.1 - 0.037 13.8 0.1 2.9 7.6 0.0 2.6 2 0 0 2 2 2 0 Cytidylate kinase Guanylate_kin PF00625.21 AIC15426.1 - 0.049 13.3 0.2 12 5.5 0.0 3.7 2 2 2 4 4 4 0 Guanylate kinase Molydop_binding PF01568.21 AIC15426.1 - 0.05 13.6 0.2 0.45 10.6 0.0 2.4 2 1 1 3 3 2 0 Molydopterin dinucleotide binding domain T2SSE PF00437.20 AIC15426.1 - 0.052 12.6 0.0 9.2 5.2 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activ_2 PF14532.6 AIC15426.1 - 0.056 13.6 0.0 19 5.4 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain Hydin_ADK PF17213.3 AIC15426.1 - 0.063 13.6 0.3 2.9 8.1 0.1 2.5 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain ResIII PF04851.15 AIC15426.1 - 0.074 13.1 0.0 9.9 6.1 0.0 2.6 3 0 0 3 3 2 0 Type III restriction enzyme, res subunit CPT PF07931.12 AIC15426.1 - 0.077 12.8 0.0 4.4 7.1 0.0 2.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein LID PF17916.1 AIC15426.1 - 0.094 12.4 0.8 4.3 7.1 0.2 2.7 2 0 0 2 2 2 0 LIM interaction domain (LID) Zot PF05707.12 AIC15426.1 - 0.13 11.9 0.0 1.9 8.1 0.0 2.7 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) Torsin PF06309.11 AIC15426.1 - 0.15 12.2 0.0 3.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Torsin DAP3 PF10236.9 AIC15426.1 - 0.15 11.2 0.0 17 4.4 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 RibD_C PF01872.17 AIC15427.1 - 5.7e-17 62.2 0.0 1.6e-11 44.4 0.0 2.0 1 1 1 2 2 2 2 RibD C-terminal domain DHFR_1 PF00186.19 AIC15427.1 - 5.2e-08 32.7 0.0 6.8e-08 32.4 0.0 1.1 1 0 0 1 1 1 1 Dihydrofolate reductase Aminotran_5 PF00266.19 AIC15429.1 - 4.2e-34 118.1 0.0 5.5e-34 117.7 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 AIC15429.1 - 0.0016 17.1 0.0 0.0023 16.5 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme DUF3156 PF11354.8 AIC15432.1 - 0.12 12.3 0.3 0.25 11.2 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3156) Replic_Relax PF13814.6 AIC15434.1 - 0.011 15.8 0.1 0.014 15.5 0.1 1.1 1 0 0 1 1 1 0 Replication-relaxation MarR_2 PF12802.7 AIC15434.1 - 0.018 14.9 0.0 0.022 14.7 0.0 1.1 1 0 0 1 1 1 0 MarR family NDUFB11 PF17250.2 AIC15434.1 - 0.033 14.8 0.0 0.051 14.2 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase 11 kDa subunit HTH_30 PF13556.6 AIC15434.1 - 0.061 13.1 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DUF4797 PF16051.5 AIC15437.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4797) Cupredoxin_1 PF13473.6 AIC15438.1 - 0.015 15.4 0.0 0.12 12.4 0.0 2.3 2 1 0 2 2 2 0 Cupredoxin-like domain FlaE PF07559.14 AIC15438.1 - 0.14 12.7 1.3 1.1 9.9 1.2 2.1 1 1 0 1 1 1 0 Flagellar basal body protein FlaE Gmad1 PF10647.9 AIC15440.1 - 0.00087 19.1 0.0 0.0012 18.7 0.0 1.2 1 0 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain eIF2A PF08662.11 AIC15440.1 - 0.02 14.8 0.1 7.1 6.4 0.0 2.5 2 1 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A FKBP26_C PF18046.1 AIC15441.1 - 4.2e-17 62.0 1.5 7.2e-17 61.3 1.5 1.4 1 0 0 1 1 1 1 FKBP26_C-terminal FKBP_C PF00254.28 AIC15441.1 - 1.2e-10 41.6 0.0 2.6e-10 40.5 0.0 1.6 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Tn7_Tnp_TnsA_C PF08721.11 AIC15441.1 - 0.042 14.5 0.0 5.2 7.8 0.0 2.5 2 1 0 2 2 2 0 TnsA endonuclease C terminal Fe-S_biosyn PF01521.20 AIC15442.1 - 8.3e-26 90.4 0.0 9.3e-26 90.2 0.0 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis HTH_45 PF14947.6 AIC15443.1 - 0.0001 22.2 0.1 0.00019 21.4 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_5 PF01022.20 AIC15443.1 - 0.00044 20.1 0.1 0.00085 19.1 0.0 1.5 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC15443.1 - 0.0058 16.7 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain DUF4364 PF14277.6 AIC15443.1 - 0.023 14.5 0.0 0.036 13.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Myb_DNA-binding PF00249.31 AIC15443.1 - 0.29 11.4 1.2 0.62 10.3 0.6 1.9 1 1 1 2 2 2 0 Myb-like DNA-binding domain TIMP PF00965.17 AIC15444.1 - 0.00048 20.0 0.0 0.001 18.9 0.0 1.5 1 1 0 1 1 1 1 Tissue inhibitor of metalloproteinase DUF4776 PF16003.5 AIC15444.1 - 0.093 11.7 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) MFS_1 PF07690.16 AIC15445.1 - 1.9e-44 152.0 46.8 6.5e-43 147.0 47.9 2.4 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AIC15445.1 - 4.1e-10 39.1 12.4 4.1e-10 39.1 12.4 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter TRI12 PF06609.13 AIC15445.1 - 1.2e-06 27.3 13.0 1.9e-06 26.6 13.0 1.2 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) DUF212 PF02681.14 AIC15445.1 - 0.0074 16.4 1.4 0.022 14.9 0.5 2.3 2 0 0 2 2 2 1 Divergent PAP2 family HTH_5 PF01022.20 AIC15446.1 - 9.5e-07 28.6 0.3 2.2e-06 27.4 0.3 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIC15446.1 - 5.7e-05 22.9 0.0 0.00018 21.3 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_11 PF08279.12 AIC15446.1 - 6e-05 22.9 0.2 0.00013 21.8 0.2 1.5 1 0 0 1 1 1 1 HTH domain HTH_34 PF13601.6 AIC15446.1 - 7.7e-05 22.8 0.4 0.00015 21.9 0.1 1.6 2 0 0 2 2 1 1 Winged helix DNA-binding domain MarR PF01047.22 AIC15446.1 - 8.2e-05 22.5 0.1 0.0002 21.2 0.1 1.6 1 0 0 1 1 1 1 MarR family HTH_20 PF12840.7 AIC15446.1 - 8.4e-05 22.6 0.1 0.00079 19.4 0.3 2.2 1 1 1 2 2 2 1 Helix-turn-helix domain HTH_24 PF13412.6 AIC15446.1 - 9.2e-05 21.9 0.1 0.00031 20.2 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 AIC15446.1 - 0.00014 21.7 0.5 0.00046 20.0 0.1 2.0 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 AIC15446.1 - 0.00031 20.6 0.0 0.00084 19.2 0.0 1.8 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Rrf2 PF02082.20 AIC15446.1 - 0.00036 20.8 0.3 0.00095 19.5 0.3 1.7 1 0 0 1 1 1 1 Transcriptional regulator HTH_IclR PF09339.10 AIC15446.1 - 0.00052 19.8 0.1 0.0013 18.5 0.1 1.7 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_10 PF04967.12 AIC15446.1 - 0.00082 19.1 0.0 0.0023 17.7 0.0 1.8 1 0 0 1 1 1 1 HTH DNA binding domain FaeA PF04703.12 AIC15446.1 - 0.0011 19.3 0.2 0.0023 18.3 0.2 1.5 1 0 0 1 1 1 1 FaeA-like protein B-block_TFIIIC PF04182.12 AIC15446.1 - 0.0014 18.8 0.0 0.0036 17.4 0.0 1.7 1 1 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_DeoR PF08220.12 AIC15446.1 - 0.0023 17.6 0.2 0.0044 16.7 0.2 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_27 PF13463.6 AIC15446.1 - 0.0078 16.7 0.2 0.018 15.5 0.0 1.7 2 0 0 2 2 1 1 Winged helix DNA-binding domain DUF2250 PF10007.9 AIC15446.1 - 0.011 15.8 1.0 0.027 14.6 1.0 1.7 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2250) DUF4294 PF14127.6 AIC15446.1 - 0.021 14.8 0.0 0.035 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4294) GntR PF00392.21 AIC15446.1 - 0.027 14.1 0.2 0.051 13.2 0.2 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family LexA_DNA_bind PF01726.16 AIC15446.1 - 0.031 14.0 0.4 0.11 12.3 0.2 1.9 2 0 0 2 2 2 0 LexA DNA binding domain HTH_9 PF08221.11 AIC15446.1 - 0.041 14.0 0.2 0.076 13.1 0.2 1.4 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Fe_dep_repress PF01325.19 AIC15446.1 - 0.048 13.9 1.0 0.095 12.9 0.2 2.0 3 0 0 3 3 2 0 Iron dependent repressor, N-terminal DNA binding domain FeoC PF09012.10 AIC15446.1 - 0.051 13.6 0.4 0.12 12.4 0.4 1.6 1 0 0 1 1 1 0 FeoC like transcriptional regulator SMC_ScpB PF04079.16 AIC15446.1 - 0.072 12.7 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB MetOD1 PF18546.1 AIC15446.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Metanogen output domain 1 AsnC_trans_reg PF01037.21 AIC15448.1 - 7.5e-11 41.9 0.2 8.1e-11 41.7 0.2 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain Gln-synt_C PF00120.24 AIC15449.1 - 8.7e-106 353.8 0.0 1e-105 353.5 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 AIC15449.1 - 2.4e-16 59.2 0.0 5.4e-16 58.1 0.0 1.6 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain HTH_AsnC-type PF13404.6 AIC15450.1 - 2.5e-16 59.2 0.1 4.8e-16 58.3 0.1 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIC15450.1 - 6.7e-16 57.6 0.0 1.4e-15 56.6 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 AIC15450.1 - 4.1e-12 45.9 0.1 7.1e-12 45.1 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain Fe_dep_repress PF01325.19 AIC15450.1 - 3e-05 24.1 0.1 6.5e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_23 PF13384.6 AIC15450.1 - 3.4e-05 23.5 0.0 6.7e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Homeodomain-like domain TrmB PF01978.19 AIC15450.1 - 6.2e-05 22.8 0.1 0.00011 21.9 0.1 1.5 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_5 PF01022.20 AIC15450.1 - 0.0003 20.6 0.0 0.0007 19.4 0.0 1.7 2 0 0 2 2 1 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 AIC15450.1 - 0.00032 20.6 0.0 0.00061 19.7 0.0 1.6 1 1 0 1 1 1 1 HTH domain HTH_38 PF13936.6 AIC15450.1 - 0.00036 20.2 0.0 0.0013 18.4 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 AIC15450.1 - 0.0005 19.9 0.0 0.0009 19.1 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 AIC15450.1 - 0.001 19.0 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 AIC15450.1 - 0.0013 19.1 0.1 0.0056 17.0 0.0 2.0 2 0 0 2 2 2 1 Transcriptional regulator HTH_28 PF13518.6 AIC15450.1 - 0.0015 18.6 0.0 0.0024 18.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Mga PF08280.11 AIC15450.1 - 0.0026 17.8 0.0 0.0056 16.7 0.0 1.6 1 0 0 1 1 1 1 M protein trans-acting positive regulator (MGA) HTH domain HTH_20 PF12840.7 AIC15450.1 - 0.0027 17.7 0.0 0.0045 17.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR PF01047.22 AIC15450.1 - 0.0036 17.2 0.0 0.0072 16.2 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_IclR PF09339.10 AIC15450.1 - 0.0086 15.9 0.0 0.015 15.0 0.0 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIC15450.1 - 0.0092 15.6 0.0 0.019 14.6 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_30 PF13556.6 AIC15450.1 - 0.017 14.9 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain HTH_10 PF04967.12 AIC15450.1 - 0.022 14.6 0.0 0.048 13.5 0.0 1.6 1 0 0 1 1 1 0 HTH DNA binding domain HTH_50 PF18024.1 AIC15450.1 - 0.03 13.9 0.0 0.11 12.1 0.0 1.9 2 0 0 2 2 1 0 Helix-turn-helix domain GntR PF00392.21 AIC15450.1 - 0.033 13.9 0.1 0.057 13.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family TnsD PF15978.5 AIC15450.1 - 0.044 12.8 0.0 0.045 12.7 0.0 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D IF2_N PF04760.15 AIC15450.1 - 0.048 13.5 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Translation initiation factor IF-2, N-terminal region HTH_Tnp_ISL3 PF13542.6 AIC15450.1 - 0.062 12.7 0.0 0.3 10.5 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 TetR_N PF00440.23 AIC15450.1 - 0.081 12.7 0.0 0.48 10.2 0.0 2.2 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Trp_repressor PF01371.19 AIC15450.1 - 0.083 13.0 0.1 0.2 11.8 0.0 1.7 2 0 0 2 2 2 0 Trp repressor protein HTH_47 PF16221.5 AIC15450.1 - 0.099 12.2 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 winged helix-turn-helix HTH_29 PF13551.6 AIC15450.1 - 0.13 12.3 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix DUF190 PF02641.15 AIC15451.1 - 1.4e-21 76.6 0.0 1.6e-21 76.5 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 Lactonase PF10282.9 AIC15453.1 - 1.2e-09 37.9 3.2 8.8e-06 25.2 0.1 3.3 1 1 2 3 3 3 2 Lactonase, 7-bladed beta-propeller Cytochrom_D1 PF02239.16 AIC15453.1 - 3.8e-09 35.6 3.3 4.2e-05 22.2 0.5 2.9 1 1 2 3 3 3 3 Cytochrome D1 heme domain NHL PF01436.21 AIC15453.1 - 1.6e-07 31.0 32.5 0.022 14.8 0.4 9.9 11 0 0 11 11 11 3 NHL repeat SGL PF08450.12 AIC15453.1 - 1.3e-05 24.9 5.9 0.0029 17.2 4.1 3.0 1 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Neur PF00064.18 AIC15453.1 - 0.0019 17.1 0.1 0.17 10.7 0.0 2.8 1 1 2 3 3 3 1 Neuraminidase He_PIG PF05345.12 AIC15453.1 - 0.0062 16.7 5.9 8.2 6.7 0.0 4.4 4 0 0 4 4 4 2 Putative Ig domain Arylesterase PF01731.20 AIC15453.1 - 0.0083 16.3 16.8 0.54 10.5 0.2 5.8 2 1 5 7 7 7 1 Arylesterase PHB_acc_N PF07879.11 AIC15453.1 - 0.03 14.4 2.2 8.8 6.5 0.1 2.9 2 0 0 2 2 2 0 PHB/PHA accumulation regulator DNA-binding domain DUF5027 PF16430.5 AIC15453.1 - 0.22 11.3 16.6 0.51 10.1 0.3 4.1 1 1 4 5 5 5 0 Domain of unknown function (DUF5027) PBP5_C PF07943.13 AIC15453.1 - 0.34 11.2 2.0 69 3.8 0.0 4.2 4 1 1 5 5 5 0 Penicillin-binding protein 5, C-terminal domain SpoIISB_antitox PF14185.6 AIC15453.1 - 0.38 10.7 2.1 1e+02 2.9 0.0 4.5 5 0 0 5 5 5 0 Antitoxin SpoIISB, type II toxin-antitoxin system DUF4346 PF14251.6 AIC15453.1 - 1.2 9.2 3.8 60 3.7 0.1 3.8 1 1 3 4 4 4 0 Domain of unknown function (DUF4346) Toxin-deaminase PF14424.6 AIC15453.1 - 2.1 8.4 6.2 21 5.2 3.2 3.1 1 1 1 2 2 2 0 The BURPS668_1122 family of deaminases DUF190 PF02641.15 AIC15454.1 - 1.2e-17 64.0 0.0 1.3e-17 63.8 0.0 1.0 1 0 0 1 1 1 1 Uncharacterized ACR, COG1993 Hydrolase_3 PF08282.12 AIC15455.1 - 6e-08 32.7 0.0 3.6e-07 30.2 0.0 2.0 2 1 1 3 3 3 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AIC15455.1 - 0.0016 18.1 0.0 0.0024 17.5 0.0 1.3 1 0 0 1 1 1 1 Sucrose-6F-phosphate phosphohydrolase YqcI_YcgG PF08892.11 AIC15455.1 - 0.082 12.7 0.0 0.17 11.7 0.0 1.5 1 1 0 1 1 1 0 YqcI/YcgG family BP28CT PF08146.12 AIC15455.1 - 0.12 12.3 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 BP28CT (NUC211) domain ELFV_dehydrog PF00208.21 AIC15456.1 - 1.4e-74 250.9 5.7 1.4e-74 250.9 5.7 1.4 2 0 0 2 2 2 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 AIC15456.1 - 2.2e-59 199.0 0.0 4.5e-59 198.0 0.0 1.6 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.19 AIC15456.1 - 0.036 13.4 0.3 0.076 12.4 0.3 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MttA_Hcf106 PF02416.16 AIC15457.1 - 2.1e-11 43.0 0.3 3e-11 42.5 0.3 1.4 1 1 0 1 1 1 1 mttA/Hcf106 family DUF4389 PF14333.6 AIC15457.1 - 0.035 14.0 0.1 0.053 13.5 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) Translin PF01997.16 AIC15458.1 - 1.3e-08 35.1 0.1 2.3e-07 31.0 0.1 2.1 1 1 0 1 1 1 1 Translin family Hjc PF01870.18 AIC15459.1 - 2.6e-08 33.7 0.0 3.9e-08 33.2 0.0 1.4 1 0 0 1 1 1 1 Archaeal holliday junction resolvase (hjc) BsuBI_PstI_RE PF06616.11 AIC15459.1 - 0.06 12.6 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain VRR_NUC PF08774.11 AIC15459.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 VRR-NUC domain Cyclophil_like PF04126.13 AIC15460.1 - 1.8e-28 98.8 0.0 2.1e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Cyclophilin-like Cyclophil_like2 PF18050.1 AIC15460.1 - 8.8e-05 22.4 0.0 0.00012 22.0 0.0 1.3 1 1 0 1 1 1 1 Cyclophilin-like family SNase PF00565.17 AIC15461.1 - 3e-09 37.3 0.0 8.2e-09 35.9 0.0 1.7 2 0 0 2 2 2 1 Staphylococcal nuclease homologue TFIIB PF00382.19 AIC15462.1 - 1.4e-30 105.2 1.3 1.6e-14 53.7 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIC15462.1 - 1.4e-10 40.5 0.1 2.3e-10 39.8 0.1 1.4 1 0 0 1 1 1 1 TFIIB zinc-binding Sigma70_r4 PF04545.16 AIC15462.1 - 4.4e-05 22.9 0.1 0.0022 17.5 0.0 2.6 2 0 0 2 2 2 1 Sigma-70, region 4 HTH_AsnC-type PF13404.6 AIC15462.1 - 0.00025 20.8 0.1 0.0026 17.6 0.0 2.7 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain HARE-HTH PF05066.13 AIC15462.1 - 0.002 18.5 0.1 0.0076 16.6 0.0 2.0 2 0 0 2 2 2 1 HB1, ASXL, restriction endonuclease HTH domain Rrf2 PF02082.20 AIC15462.1 - 0.003 17.9 0.2 4.5 7.7 0.0 2.7 2 1 0 2 2 2 2 Transcriptional regulator HTH_11 PF08279.12 AIC15462.1 - 0.0066 16.4 0.8 0.065 13.2 0.1 2.5 3 0 0 3 3 3 1 HTH domain LacI PF00356.21 AIC15462.1 - 0.0072 16.1 2.4 0.81 9.5 0.3 3.3 3 0 0 3 3 3 1 Bacterial regulatory proteins, lacI family HTH_Tnp_ISL3 PF13542.6 AIC15462.1 - 0.023 14.1 0.0 0.13 11.7 0.0 2.3 2 0 0 2 2 2 0 Helix-turn-helix domain of transposase family ISL3 Sigma70_r4_2 PF08281.12 AIC15462.1 - 0.024 14.3 0.1 0.12 12.1 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_23 PF13384.6 AIC15462.1 - 0.036 13.9 0.2 0.2 11.5 0.0 2.4 2 0 0 2 2 2 0 Homeodomain-like domain Phage_terminase PF10668.9 AIC15462.1 - 0.042 13.9 0.0 2 8.5 0.0 2.4 2 0 0 2 2 2 0 Phage terminase small subunit HTH_36 PF13730.6 AIC15462.1 - 0.053 13.5 1.1 1.5 8.8 0.0 3.2 3 0 0 3 3 3 0 Helix-turn-helix domain RB_B PF01857.20 AIC15462.1 - 0.055 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain TetR_N PF00440.23 AIC15462.1 - 0.06 13.2 0.1 9.6 6.1 0.0 2.6 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family GerE PF00196.19 AIC15462.1 - 0.07 12.7 0.7 0.57 9.8 0.0 2.5 3 0 0 3 3 3 0 Bacterial regulatory proteins, luxR family HTH_Crp_2 PF13545.6 AIC15462.1 - 0.23 11.5 1.2 1.7 8.7 0.1 2.6 3 0 0 3 3 3 0 Crp-like helix-turn-helix domain ZT_dimer PF16916.5 AIC15463.1 - 1.1e-43 147.2 10.4 1.5e-16 60.3 0.8 3.3 3 0 0 3 3 3 3 Dimerisation domain of Zinc Transporter Cation_efflux PF01545.21 AIC15463.1 - 1.1e-33 116.6 19.7 1.5e-33 116.2 19.7 1.2 1 0 0 1 1 1 1 Cation efflux family AMP-binding_C_2 PF14535.6 AIC15463.1 - 0.00017 21.9 2.8 0.00066 19.9 0.2 2.5 3 0 0 3 3 3 1 AMP-binding enzyme C-terminal domain FAS_meander PF17951.1 AIC15463.1 - 0.096 12.5 0.0 0.29 11.0 0.0 1.8 1 0 0 1 1 1 0 Fatty acid synthase meander beta sheet domain Carb_kinase PF01256.17 AIC15464.1 - 4.5e-40 137.6 0.2 5.3e-40 137.4 0.2 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 AIC15464.1 - 4.6e-05 22.9 0.0 7.2e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 AIC15464.1 - 0.005 16.2 0.1 0.013 14.9 0.1 1.8 2 1 0 2 2 2 1 Phosphomethylpyrimidine kinase adh_short PF00106.25 AIC15465.1 - 3.1e-50 170.3 0.1 4e-50 170.0 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIC15465.1 - 1.4e-32 113.1 0.0 1.8e-32 112.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIC15465.1 - 1.2e-09 38.4 0.0 1.8e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AIC15465.1 - 1.8e-07 30.8 0.0 2.6e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) NAD_binding_10 PF13460.6 AIC15465.1 - 0.00025 21.0 0.0 0.00033 20.6 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 AIC15465.1 - 0.00035 20.1 0.0 0.0011 18.5 0.0 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family tRNA_bind PF01588.20 AIC15466.1 - 9.5e-19 67.3 0.1 1.1e-18 67.1 0.1 1.1 1 0 0 1 1 1 1 Putative tRNA binding domain HupF_HypC PF01455.18 AIC15466.1 - 0.075 13.2 0.1 0.13 12.4 0.1 1.5 1 1 0 1 1 1 0 HupF/HypC family EF-hand_1 PF00036.32 AIC15466.1 - 0.15 11.7 0.1 0.34 10.6 0.1 1.5 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 AIC15466.1 - 0.22 11.5 0.3 0.56 10.3 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain PAC2 PF09754.9 AIC15467.1 - 5.7e-28 98.4 0.0 7.1e-28 98.1 0.0 1.0 1 0 0 1 1 1 1 PAC2 family NAD_binding_2 PF03446.15 AIC15468.1 - 2.7e-39 134.9 0.5 4.3e-39 134.2 0.2 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 AIC15468.1 - 1.3e-25 90.0 0.5 2.6e-25 89.0 0.5 1.5 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase 3HCDH_N PF02737.18 AIC15468.1 - 1.8e-08 34.5 0.0 0.00014 21.8 0.1 2.2 1 1 1 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AIC15468.1 - 1.1e-07 32.3 0.1 9.8e-07 29.3 0.0 2.2 2 0 0 2 2 2 1 NADP oxidoreductase coenzyme F420-dependent 2-Hacid_dh_C PF02826.19 AIC15468.1 - 1e-06 28.2 0.0 1.6e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 AIC15468.1 - 0.0027 17.8 0.0 0.0077 16.3 0.0 1.7 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 AIC15468.1 - 0.012 15.2 0.0 0.023 14.3 0.0 1.6 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Epimerase PF01370.21 AIC15468.1 - 0.095 12.1 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family GMC_oxred_N PF00732.19 AIC15470.1 - 2.9e-36 125.4 0.7 4e-36 124.9 0.7 1.2 1 0 0 1 1 1 1 GMC oxidoreductase GMC_oxred_C PF05199.13 AIC15470.1 - 2e-25 90.0 0.1 3.9e-25 89.1 0.1 1.5 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 AIC15470.1 - 6.8e-08 32.0 4.0 0.00036 19.7 1.9 2.3 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 AIC15470.1 - 1.6e-07 31.2 0.2 0.00055 19.6 0.0 2.4 2 0 0 2 2 2 2 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 AIC15470.1 - 1.5e-06 27.7 0.8 0.0013 18.1 0.2 2.5 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AIC15470.1 - 0.00011 22.3 0.7 0.0003 20.9 0.7 1.7 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 AIC15470.1 - 0.00036 19.9 0.1 0.00059 19.2 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 AIC15470.1 - 0.00051 18.9 0.9 0.00089 18.1 0.9 1.3 1 0 0 1 1 1 1 HI0933-like protein FAD_oxidored PF12831.7 AIC15470.1 - 0.0027 17.1 0.9 0.0042 16.5 0.9 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase ApbA PF02558.16 AIC15470.1 - 0.0032 17.1 0.1 0.0062 16.2 0.1 1.4 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA GIDA PF01134.22 AIC15470.1 - 0.012 14.7 0.1 0.083 12.0 0.0 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 AIC15470.1 - 0.014 14.4 0.4 0.027 13.5 0.4 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein GDI PF00996.18 AIC15470.1 - 0.067 11.7 0.1 0.14 10.7 0.0 1.5 2 0 0 2 2 2 0 GDP dissociation inhibitor ELFV_dehydrog PF00208.21 AIC15470.1 - 0.11 12.2 0.3 0.18 11.5 0.3 1.3 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 3HCDH_N PF02737.18 AIC15470.1 - 0.14 12.1 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_Gly3P_dh_N PF01210.23 AIC15470.1 - 0.16 11.9 0.0 0.3 11.1 0.0 1.4 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus TTR-52 PF01060.23 AIC15471.1 - 5.8e-05 23.7 0.0 0.00011 22.8 0.0 1.5 1 1 0 1 1 1 1 Transthyretin-like family CarboxypepD_reg PF13620.6 AIC15471.1 - 6.9e-05 23.0 0.0 0.00013 22.2 0.0 1.5 1 1 0 1 1 1 1 Carboxypeptidase regulatory-like domain Big_1 PF02369.16 AIC15471.1 - 0.003 17.5 0.0 0.0058 16.6 0.0 1.4 1 0 0 1 1 1 1 Bacterial Ig-like domain (group 1) Dioxygenase_C PF00775.21 AIC15471.1 - 0.062 12.7 0.0 0.12 11.8 0.0 1.6 1 1 0 1 1 1 0 Dioxygenase Radical_SAM PF04055.21 AIC15473.1 - 4.1e-12 46.8 0.1 6.2e-12 46.2 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 AIC15473.1 - 0.0056 16.9 0.0 0.012 15.8 0.0 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain DUF5131 PF07505.11 AIC15473.1 - 0.014 14.9 0.8 0.1 12.0 0.7 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF5131) Fer4_14 PF13394.6 AIC15473.1 - 0.033 14.3 0.1 0.082 13.1 0.1 1.7 1 0 0 1 1 1 0 4Fe-4S single cluster domain DUF1848 PF08902.11 AIC15473.1 - 0.14 11.8 4.5 0.95 9.1 4.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1848) NUDIX PF00293.28 AIC15474.1 - 4.8e-20 71.9 0.0 6e-20 71.6 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain NUDIX_4 PF14815.6 AIC15474.1 - 6.1e-05 23.0 0.0 0.00011 22.2 0.0 1.4 1 1 0 1 1 1 1 NUDIX domain DUF4916 PF16262.5 AIC15474.1 - 0.0025 17.3 0.0 0.0084 15.6 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4916) RNAse_A_bac PF18431.1 AIC15475.1 - 0.056 14.4 0.1 0.074 14.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial CdiA-CT RNAse A domain UPF0051 PF01458.17 AIC15476.1 - 2.1e-74 249.9 0.2 3e-74 249.4 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) UPF0051 PF01458.17 AIC15477.1 - 8.4e-57 192.3 0.8 1.2e-56 191.8 0.8 1.2 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) Rieske PF00355.26 AIC15478.1 - 9.5e-17 60.7 0.0 1.1e-16 60.5 0.0 1.0 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIC15478.1 - 1e-12 47.9 0.0 1.2e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Aminotran_5 PF00266.19 AIC15479.1 - 3.7e-152 506.6 0.8 4.2e-152 506.4 0.8 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AIC15479.1 - 0.00011 21.6 0.0 0.00023 20.6 0.0 1.4 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 AIC15479.1 - 0.00046 19.5 0.1 0.0008 18.7 0.1 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AIC15479.1 - 0.0005 18.7 0.0 0.00077 18.1 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme SelA PF03841.13 AIC15479.1 - 0.041 12.9 0.1 0.15 11.0 0.1 1.8 1 1 0 1 1 1 0 L-seryl-tRNA selenium transferase NifU_N PF01592.16 AIC15480.1 - 7.3e-33 113.4 0.0 9e-33 113.1 0.0 1.0 1 0 0 1 1 1 1 NifU-like N terminal domain Lip_prot_lig_C PF10437.9 AIC15480.1 - 0.043 13.8 0.4 0.084 12.9 0.3 1.7 1 1 0 1 1 1 0 Bacterial lipoate protein ligase C-terminus TSCPD PF12637.7 AIC15480.1 - 0.058 13.6 0.1 0.083 13.1 0.1 1.3 1 0 0 1 1 1 0 TSCPD domain SAM_1 PF00536.30 AIC15480.1 - 0.11 13.0 0.1 0.24 11.9 0.1 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF35_N PF12172.8 AIC15481.1 - 0.0023 17.8 0.3 0.026 14.4 0.3 2.1 1 1 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 AIC15481.1 - 0.0053 16.8 1.2 0.0078 16.2 1.2 1.2 1 0 0 1 1 1 1 Double zinc ribbon Phage_TAC_12 PF12363.8 AIC15481.1 - 0.056 13.9 0.0 0.12 12.8 0.0 1.5 1 1 1 2 2 2 0 Phage tail assembly chaperone protein, TAC Peptidase_C69 PF03577.15 AIC15481.1 - 0.061 12.2 0.0 0.072 12.0 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C69 Zn-ribbon_8 PF09723.10 AIC15481.1 - 0.062 13.4 3.3 0.17 12.0 3.3 1.8 1 1 0 1 1 1 0 Zinc ribbon domain zf-trcl PF13451.6 AIC15481.1 - 0.15 12.0 8.4 1 9.3 2.4 2.2 1 1 1 2 2 2 0 Probable zinc-ribbon domain PAP2 PF01569.21 AIC15482.1 - 3.4e-20 72.2 4.5 3.4e-20 72.2 4.5 2.2 2 1 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 AIC15482.1 - 1.9e-08 34.2 11.1 1.9e-08 34.2 11.1 1.9 1 1 1 2 2 2 1 PAP2 superfamily PAP2_C PF14360.6 AIC15482.1 - 0.057 14.0 0.4 0.057 14.0 0.4 2.7 3 0 0 3 3 3 0 PAP2 superfamily C-terminal DUF4133 PF13571.6 AIC15482.1 - 0.34 11.3 3.5 0.53 10.7 1.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Wzy_C PF04932.15 AIC15482.1 - 2.6 7.7 14.7 0.9 9.2 2.3 2.9 3 1 0 3 3 3 0 O-Antigen ligase FAD_binding_2 PF00890.24 AIC15484.1 - 3.5e-07 29.7 0.1 0.0037 16.4 0.0 2.2 2 0 0 2 2 2 2 FAD binding domain DAO PF01266.24 AIC15484.1 - 2.9e-06 27.1 0.4 0.016 14.8 0.0 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase Trp_halogenase PF04820.14 AIC15484.1 - 0.0035 16.3 0.1 0.17 10.7 0.1 2.2 2 0 0 2 2 2 1 Tryptophan halogenase Pyr_redox_2 PF07992.14 AIC15484.1 - 0.0093 15.2 1.2 0.1 11.8 0.2 2.3 1 1 1 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GDI PF00996.18 AIC15484.1 - 0.016 13.7 0.0 0.1 11.1 0.0 1.9 2 0 0 2 2 2 0 GDP dissociation inhibitor Thi4 PF01946.17 AIC15484.1 - 0.033 13.4 0.5 0.16 11.2 0.6 2.1 2 1 0 2 2 2 0 Thi4 family HI0933_like PF03486.14 AIC15484.1 - 0.15 10.7 0.5 0.37 9.4 0.1 1.7 2 0 0 2 2 2 0 HI0933-like protein NAD_binding_8 PF13450.6 AIC15484.1 - 0.16 12.2 0.1 0.5 10.6 0.1 1.9 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain FAD_oxidored PF12831.7 AIC15484.1 - 0.49 9.7 2.1 1.5 8.1 2.1 1.7 1 1 0 1 1 1 0 FAD dependent oxidoreductase HAD_2 PF13419.6 AIC15485.1 - 4.3e-18 66.0 0.0 7.3e-18 65.3 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIC15485.1 - 5.3e-12 45.6 0.0 9.1e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 AIC15485.1 - 1.8e-10 41.5 0.0 2.4e-10 41.1 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 AIC15485.1 - 0.00074 19.2 0.0 0.0011 18.6 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase DUF962 PF06127.11 AIC15486.1 - 0.00024 21.1 0.4 0.00031 20.7 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF962) HIT PF01230.23 AIC15487.1 - 4.6e-23 81.8 0.1 5.9e-23 81.5 0.1 1.1 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 AIC15487.1 - 2.1e-14 54.0 0.0 2.7e-14 53.6 0.0 1.1 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 AIC15487.1 - 0.00087 19.1 0.4 0.0021 17.9 0.4 1.5 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 PAPS_reduct PF01507.19 AIC15489.1 - 2.3e-44 151.5 0.0 2.9e-44 151.2 0.0 1.1 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family ATP-sulfurylase PF01747.17 AIC15490.1 - 3.7e-84 281.4 0.2 4.7e-84 281.1 0.2 1.1 1 0 0 1 1 1 1 ATP-sulfurylase PUA_2 PF14306.6 AIC15490.1 - 1.5e-40 138.5 0.0 2.6e-40 137.7 0.0 1.4 1 0 0 1 1 1 1 PUA-like domain HTH_5 PF01022.20 AIC15493.1 - 1.1e-09 37.9 0.0 2e-09 37.2 0.0 1.3 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC15493.1 - 2.9e-07 30.5 0.0 5.6e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_45 PF14947.6 AIC15493.1 - 0.00021 21.2 0.3 0.00031 20.7 0.3 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix TrmB PF01978.19 AIC15493.1 - 0.00028 20.7 0.0 0.00054 19.8 0.0 1.5 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIC15493.1 - 0.00088 18.8 0.0 0.0028 17.2 0.0 1.9 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 AIC15493.1 - 0.003 17.4 0.0 0.0053 16.7 0.0 1.4 1 0 0 1 1 1 1 HTH domain Phage_rep_org_N PF09681.10 AIC15493.1 - 0.011 15.6 0.1 0.015 15.3 0.1 1.2 1 0 0 1 1 1 0 N-terminal phage replisome organiser (Phage_rep_org_N) Nup35_RRM PF05172.13 AIC15493.1 - 0.024 14.6 0.0 0.031 14.2 0.0 1.2 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif MarR_2 PF12802.7 AIC15493.1 - 0.026 14.4 0.0 0.045 13.7 0.0 1.4 1 0 0 1 1 1 0 MarR family Dimerisation2 PF16864.5 AIC15493.1 - 0.044 13.8 0.0 0.067 13.2 0.0 1.2 1 0 0 1 1 1 0 Dimerisation domain B-block_TFIIIC PF04182.12 AIC15493.1 - 0.11 12.7 0.1 0.94 9.7 0.0 2.1 2 0 0 2 2 2 0 B-block binding subunit of TFIIIC LexA_DNA_bind PF01726.16 AIC15493.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 LexA DNA binding domain Penicillinase_R PF03965.16 AIC15493.1 - 0.16 12.3 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 Penicillinase repressor DUF3179 PF11376.8 AIC15494.1 - 3.1e-105 351.6 0.0 4e-105 351.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3179) LapA_dom PF06305.11 AIC15495.1 - 0.06 13.2 0.2 0.075 12.9 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2517 PF10725.9 AIC15495.1 - 0.14 12.0 0.0 0.15 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2517) DUF1887 PF09002.11 AIC15496.1 - 0.0021 16.8 0.0 0.0029 16.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1887) WAK_assoc PF14380.6 AIC15497.1 - 0.067 13.9 0.7 0.092 13.5 0.0 1.6 2 0 0 2 2 2 0 Wall-associated receptor kinase C-terminal HTH_10 PF04967.12 AIC15498.1 - 6.1e-19 67.6 0.4 1e-18 66.8 0.4 1.4 1 0 0 1 1 1 1 HTH DNA binding domain HTH_5 PF01022.20 AIC15498.1 - 0.009 15.9 0.4 0.038 13.9 0.2 2.0 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family Sigma70_r4_2 PF08281.12 AIC15498.1 - 0.16 11.7 0.7 1.7 8.4 0.7 2.3 1 1 0 1 1 1 0 Sigma-70, region 4 MerB PF03243.15 AIC15499.1 - 2e-32 112.0 0.0 2.9e-32 111.5 0.0 1.2 1 0 0 1 1 1 1 Alkylmercury lyase HTH_15 PF12324.8 AIC15499.1 - 8.3e-05 22.5 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain of alkylmercury lyase RseC_MucC PF04246.12 AIC15500.1 - 5.1 7.1 9.3 0.13 12.3 1.6 2.0 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC AhpC-TSA PF00578.21 AIC15501.1 - 9.6e-14 51.4 0.0 1.5e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC15501.1 - 3.3e-11 43.1 0.0 5e-11 42.5 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 AIC15501.1 - 1.4e-06 28.5 0.0 2.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin PF00085.20 AIC15501.1 - 6.5e-05 22.9 0.0 0.0004 20.3 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin SCO1-SenC PF02630.14 AIC15501.1 - 7.1e-05 22.7 0.0 0.00011 22.2 0.0 1.4 1 1 0 1 1 1 1 SCO1/SenC Thioredoxin_7 PF13899.6 AIC15501.1 - 0.00022 21.3 0.1 0.00039 20.5 0.1 1.5 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 AIC15501.1 - 0.0036 17.7 0.1 0.008 16.6 0.1 1.6 1 1 0 1 1 1 1 Thioredoxin-like domain HxlR PF01638.17 AIC15503.1 - 2.9e-21 75.1 0.1 3.8e-21 74.7 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix B-block_TFIIIC PF04182.12 AIC15503.1 - 0.01 16.0 0.0 0.013 15.7 0.0 1.3 1 0 0 1 1 1 0 B-block binding subunit of TFIIIC HTH_24 PF13412.6 AIC15503.1 - 0.021 14.4 0.1 0.044 13.4 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR PF01047.22 AIC15503.1 - 0.023 14.6 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 MarR family PadR PF03551.14 AIC15503.1 - 0.027 14.4 0.0 0.046 13.7 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family RepL PF05732.11 AIC15503.1 - 0.064 12.7 0.0 0.074 12.5 0.0 1.1 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) ADP_ribosyl_GH PF03747.14 AIC15504.1 - 0.014 15.1 0.9 1.3 8.6 0.8 2.1 2 0 0 2 2 2 0 ADP-ribosylglycohydrolase RseC_MucC PF04246.12 AIC15504.1 - 0.04 13.9 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC Bacteriocin_IIc PF10439.9 AIC15504.1 - 0.53 10.5 6.8 0.7 10.0 6.8 1.2 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Pyr_redox_2 PF07992.14 AIC15505.1 - 1.5e-62 211.5 0.1 2e-62 211.1 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 AIC15505.1 - 4.3e-30 104.2 0.4 1e-29 103.0 0.4 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_3 PF13738.6 AIC15505.1 - 4.2e-18 65.7 0.8 1.6e-17 63.7 0.8 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AIC15505.1 - 1.7e-17 63.8 1.2 1.8e-13 50.8 0.0 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 AIC15505.1 - 3.1e-17 62.8 2.4 3.8e-14 52.6 0.1 3.3 2 2 1 3 3 3 2 Glucose inhibited division protein A FAD_oxidored PF12831.7 AIC15505.1 - 2.1e-08 34.0 7.5 2.7e-06 27.0 1.4 3.3 3 1 0 4 4 4 2 FAD dependent oxidoreductase HI0933_like PF03486.14 AIC15505.1 - 4.1e-07 29.1 6.9 0.0033 16.2 1.1 4.0 3 1 1 4 4 4 2 HI0933-like protein FAD_binding_2 PF00890.24 AIC15505.1 - 9.8e-07 28.2 5.6 7e-05 22.1 1.4 2.8 2 1 1 3 3 3 2 FAD binding domain K_oxygenase PF13434.6 AIC15505.1 - 3.3e-06 26.5 0.3 0.053 12.6 0.0 3.1 2 1 1 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 AIC15505.1 - 1.8e-05 24.9 0.7 0.047 13.9 0.5 2.6 2 0 0 2 2 2 2 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 AIC15505.1 - 0.0013 18.1 0.3 0.02 14.1 0.2 2.5 2 0 0 2 2 2 1 Thi4 family AlaDh_PNT_C PF01262.21 AIC15505.1 - 0.002 17.5 0.3 1.1 8.5 0.0 2.4 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_3 PF01494.19 AIC15505.1 - 0.0062 15.8 0.6 0.29 10.3 0.1 2.2 2 0 0 2 2 2 1 FAD binding domain DAO PF01266.24 AIC15505.1 - 0.025 14.2 5.0 0.3 10.6 1.1 2.7 2 1 0 3 3 3 0 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 AIC15505.1 - 0.025 13.6 0.7 1.5 7.8 0.6 2.6 3 0 0 3 3 3 0 Lycopene cyclase protein TrmB PF01978.19 AIC15505.1 - 0.13 12.1 0.1 0.29 11.1 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_45 PF14947.6 AIC15508.1 - 2.2e-19 69.2 0.5 2.6e-19 69.0 0.5 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC15508.1 - 2.2e-05 24.3 0.1 2.8e-05 23.9 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) HTH_27 PF13463.6 AIC15508.1 - 0.00075 19.9 0.0 0.0012 19.3 0.0 1.4 1 0 0 1 1 1 1 Winged helix DNA-binding domain RQC PF09382.10 AIC15508.1 - 0.011 15.5 0.0 0.022 14.5 0.0 1.5 1 1 0 1 1 1 0 RQC domain HxlR PF01638.17 AIC15508.1 - 0.011 15.6 0.1 0.012 15.5 0.1 1.2 1 0 0 1 1 1 0 HxlR-like helix-turn-helix YfdX PF10938.8 AIC15509.1 - 0.0035 17.3 10.4 0.39 10.6 0.6 3.7 3 0 0 3 3 3 2 YfdX protein DUF1635 PF07795.11 AIC15509.1 - 0.084 12.7 5.1 0.37 10.6 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) SMBP PF16785.5 AIC15509.1 - 2.6 8.3 8.6 3.3 8.0 1.0 2.9 2 1 0 2 2 2 0 Small metal-binding protein PTS_IIA PF02255.16 AIC15509.1 - 3.7 7.7 9.4 48 4.1 0.3 4.2 3 1 1 4 4 4 0 PTS system, Lactose/Cellobiose specific IIA subunit DUF2167 PF09935.9 AIC15510.1 - 0.064 12.4 0.0 0.094 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) DUF3997 PF13162.6 AIC15510.1 - 0.075 13.3 0.3 0.21 11.9 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3997) HhH-GPD PF00730.25 AIC15511.1 - 4.5e-27 94.6 0.0 6.7e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AIC15511.1 - 3.9e-08 32.7 0.1 1.9e-07 30.6 0.0 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix motif HHH_5 PF14520.6 AIC15511.1 - 5.4e-06 26.9 0.5 0.064 13.9 0.1 2.5 1 1 1 2 2 2 2 Helix-hairpin-helix domain DUF2400 PF09674.10 AIC15511.1 - 0.0085 16.1 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2400) Endotoxin_C2 PF18449.1 AIC15511.1 - 0.099 13.0 0.6 0.17 12.2 0.6 1.4 1 0 0 1 1 1 0 Delta endotoxin AGOG PF09171.10 AIC15511.1 - 0.11 11.8 0.0 0.24 10.7 0.0 1.5 1 0 0 1 1 1 0 N-glycosylase/DNA lyase DUF521 PF04412.13 AIC15512.1 - 7.7e-119 397.0 0.0 9.1e-119 396.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF521) DUF126 PF01989.16 AIC15513.1 - 4.4e-28 96.9 0.1 7.2e-28 96.2 0.1 1.4 1 0 0 1 1 1 1 Aconitase X swivel domain TF_Zn_Ribbon PF08271.12 AIC15514.1 - 3.7e-08 32.8 0.3 5.5e-08 32.2 0.3 1.2 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 AIC15514.1 - 8.9e-05 22.3 0.3 0.0002 21.2 0.3 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf_Rg PF17915.1 AIC15514.1 - 0.00054 19.3 0.2 0.00064 19.1 0.2 1.2 1 0 0 1 1 1 1 Reverse gyrase zinc finger zinc-ribbons_6 PF07191.12 AIC15514.1 - 0.003 17.5 0.7 0.0045 16.9 0.7 1.3 1 0 0 1 1 1 1 zinc-ribbons Zn_Tnp_IS91 PF14319.6 AIC15514.1 - 0.008 16.2 0.1 0.011 15.8 0.1 1.4 1 1 0 1 1 1 1 Transposase zinc-binding domain Zn-ribbon_8 PF09723.10 AIC15514.1 - 0.0083 16.2 1.7 2.2 8.5 0.1 2.5 2 1 0 2 2 2 2 Zinc ribbon domain NleF_casp_inhib PF16809.5 AIC15514.1 - 0.011 15.6 0.1 0.011 15.6 0.1 1.1 1 0 0 1 1 1 0 NleF caspase inhibitor Zn_Tnp_IS1595 PF12760.7 AIC15514.1 - 0.013 15.4 0.5 0.021 14.8 0.5 1.3 1 0 0 1 1 1 0 Transposase zinc-ribbon domain FYDLN_acid PF09538.10 AIC15514.1 - 0.014 16.0 1.1 0.017 15.8 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf-ribbon_3 PF13248.6 AIC15514.1 - 0.016 14.6 1.3 1.6 8.2 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Lar_restr_allev PF14354.6 AIC15514.1 - 0.03 14.7 1.0 0.062 13.7 1.0 1.6 1 1 0 1 1 1 0 Restriction alleviation protein Lar DUF2318 PF10080.9 AIC15514.1 - 0.032 14.3 0.1 0.032 14.3 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Nudix_N_2 PF14803.6 AIC15514.1 - 0.036 14.0 4.1 0.35 10.8 4.1 2.2 1 1 0 1 1 1 0 Nudix N-terminal PADR1 PF08063.12 AIC15514.1 - 0.045 13.5 1.6 0.065 13.0 1.6 1.3 1 0 0 1 1 1 0 PADR1 (NUC008) domain DZR PF12773.7 AIC15514.1 - 0.093 12.8 1.7 0.21 11.7 1.7 1.6 1 1 0 1 1 1 0 Double zinc ribbon Vps36-NZF-N PF16988.5 AIC15514.1 - 0.1 12.0 0.4 0.27 10.7 0.0 1.8 1 1 1 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF1272 PF06906.11 AIC15514.1 - 0.16 12.1 1.7 0.61 10.2 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1272) Prim_Zn_Ribbon PF08273.12 AIC15514.1 - 0.23 11.8 2.7 0.67 10.3 2.7 1.8 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase zf-IS66 PF13005.7 AIC15514.1 - 0.23 11.9 3.2 1.4 9.3 0.1 2.4 2 1 0 2 2 2 0 zinc-finger binding domain of transposase IS66 zf-NADH-PPase PF09297.11 AIC15514.1 - 0.53 10.0 2.9 3 7.6 2.9 1.9 1 1 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain zf-ACC PF17848.1 AIC15514.1 - 0.57 10.3 4.6 3.7 7.7 4.6 2.1 1 1 0 1 1 1 0 Acetyl-coA carboxylase zinc finger domain ATP_bind_3 PF01171.20 AIC15515.1 - 1e-19 71.0 0.0 1.6e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 PP-loop family CTU2 PF10288.9 AIC15515.1 - 0.012 15.8 0.6 0.1 12.9 0.1 2.4 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 NAD_synthase PF02540.17 AIC15515.1 - 0.014 14.5 0.1 0.021 14.0 0.1 1.2 1 0 0 1 1 1 0 NAD synthase tRNA_Me_trans PF03054.16 AIC15515.1 - 0.019 13.8 0.1 0.03 13.1 0.1 1.3 1 0 0 1 1 1 0 tRNA methyl transferase RecR PF02132.15 AIC15515.1 - 0.061 12.9 8.6 0.71 9.5 1.3 2.9 3 0 0 3 3 3 0 RecR protein CMV_1a_C PF12503.8 AIC15515.1 - 0.085 12.9 0.0 7.7 6.6 0.0 2.4 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein C terminal QueC PF06508.13 AIC15515.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC C1_2 PF03107.16 AIC15515.1 - 2.1 8.7 8.9 0.82 10.0 0.8 3.1 3 0 0 3 3 3 0 C1 domain Bac_luciferase PF00296.20 AIC15516.1 - 2.2e-48 165.3 0.0 2.5e-48 165.1 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Methyltransf_25 PF13649.6 AIC15518.1 - 1.4e-14 54.5 0.0 2.8e-14 53.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC15518.1 - 1.8e-11 44.6 0.0 3.2e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC15518.1 - 2.2e-10 40.6 0.0 4.4e-10 39.6 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15518.1 - 3.1e-10 40.1 0.0 8.2e-10 38.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15518.1 - 1.9e-08 35.0 0.0 4.3e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC15518.1 - 0.00021 20.7 0.0 0.00068 19.0 0.0 1.8 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 AIC15518.1 - 0.0012 18.2 0.0 0.013 14.8 0.0 2.2 2 1 1 3 3 3 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 AIC15518.1 - 0.0017 17.9 0.0 0.0031 17.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 AIC15518.1 - 0.021 14.6 0.0 0.033 13.9 0.0 1.3 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) SIS_2 PF13580.6 AIC15518.1 - 0.024 14.6 0.0 0.04 13.9 0.0 1.3 1 0 0 1 1 1 0 SIS domain SnoaL PF07366.12 AIC15518.1 - 0.059 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like polyketide cyclase MarR_2 PF12802.7 AIC15519.1 - 1.7e-14 53.4 0.0 3e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR PF01047.22 AIC15519.1 - 1.9e-11 43.7 0.0 3.1e-11 43.0 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 AIC15519.1 - 3.6e-08 33.8 0.0 7.3e-08 32.8 0.0 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 AIC15519.1 - 6.1e-06 26.0 0.0 9.1e-06 25.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_42 PF06224.12 AIC15519.1 - 0.00021 20.9 0.5 0.00023 20.8 0.5 1.1 1 0 0 1 1 1 1 Winged helix DNA-binding domain TFIIE_alpha PF02002.17 AIC15519.1 - 0.00042 20.1 0.0 0.00059 19.7 0.0 1.3 1 0 0 1 1 1 1 TFIIE alpha subunit GntR PF00392.21 AIC15519.1 - 0.00094 18.8 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family HTH_Crp_2 PF13545.6 AIC15519.1 - 0.0024 17.8 0.0 0.0055 16.7 0.0 1.5 1 1 0 1 1 1 1 Crp-like helix-turn-helix domain HTH_34 PF13601.6 AIC15519.1 - 0.0026 17.9 0.0 0.0043 17.2 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain Fe_dep_repress PF01325.19 AIC15519.1 - 0.0094 16.1 0.0 0.016 15.4 0.0 1.3 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_11 PF08279.12 AIC15519.1 - 0.012 15.5 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 HTH domain HTH_IclR PF09339.10 AIC15519.1 - 0.019 14.7 0.5 0.15 11.9 0.1 2.2 2 0 0 2 2 2 0 IclR helix-turn-helix domain DUF4423 PF14394.6 AIC15519.1 - 0.023 14.4 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) HTH_24 PF13412.6 AIC15519.1 - 0.091 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HrcA_DNA-bdg PF03444.15 AIC15519.1 - 0.1 12.3 0.0 0.2 11.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding HxlR PF01638.17 AIC15519.1 - 0.12 12.2 0.0 0.67 9.8 0.0 2.0 1 1 0 1 1 1 0 HxlR-like helix-turn-helix HTH_CodY PF08222.11 AIC15519.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 CodY helix-turn-helix domain Pyr_redox_2 PF07992.14 AIC15520.1 - 3.6e-22 79.0 0.0 8.1e-22 77.8 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIC15520.1 - 6.9e-10 38.7 0.0 0.00068 19.0 0.0 2.4 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 AIC15520.1 - 1.8e-06 27.3 1.3 3e-05 23.3 1.3 2.7 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 AIC15520.1 - 3.8e-06 25.8 0.6 0.0024 16.7 0.5 2.3 1 1 0 2 2 2 2 HI0933-like protein DAO PF01266.24 AIC15520.1 - 0.0016 18.1 5.4 0.11 12.1 0.2 2.7 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_oxidored PF12831.7 AIC15520.1 - 0.003 17.0 0.7 0.0053 16.2 0.7 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 AIC15520.1 - 0.0096 15.0 1.0 0.22 10.5 0.4 2.6 3 0 0 3 3 3 1 Lycopene cyclase protein GIDA PF01134.22 AIC15520.1 - 0.035 13.2 2.0 0.23 10.5 0.3 2.4 3 0 0 3 3 3 0 Glucose inhibited division protein A NAD_binding_9 PF13454.6 AIC15520.1 - 0.049 13.6 7.8 0.77 9.7 0.0 3.1 2 1 0 3 3 3 0 FAD-NAD(P)-binding TGT_C2 PF14810.6 AIC15520.1 - 0.081 13.1 0.0 8.1 6.7 0.0 2.5 2 0 0 2 2 2 0 Patch-forming domain C2 of tRNA-guanine transglycosylase FAD_binding_3 PF01494.19 AIC15520.1 - 0.086 12.1 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain NAD_binding_8 PF13450.6 AIC15520.1 - 0.13 12.5 0.1 0.31 11.3 0.1 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 AIC15520.1 - 0.14 11.4 0.1 0.26 10.5 0.1 1.3 1 0 0 1 1 1 0 Thi4 family DUF1697 PF08002.11 AIC15521.1 - 4.1e-37 127.7 0.0 5.1e-37 127.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1697) Ntox3 PF15536.6 AIC15521.1 - 0.1 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 3 SpaA PF17802.1 AIC15523.1 - 8.9e-05 22.7 0.1 0.00027 21.2 0.1 1.8 1 0 0 1 1 1 1 Prealbumin-like fold domain PKD PF00801.20 AIC15523.1 - 0.0027 17.5 0.6 0.0099 15.7 0.6 2.0 1 0 0 1 1 1 1 PKD domain DUF4064 PF13273.6 AIC15524.1 - 1.7 8.9 24.6 0.3 11.4 15.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) E1-E2_ATPase PF00122.20 AIC15525.1 - 2e-56 190.4 0.9 2e-56 190.4 0.9 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AIC15525.1 - 4.3e-50 170.9 8.1 5.1e-50 170.7 5.2 2.1 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIC15525.1 - 4.7e-07 29.8 2.2 0.0047 16.7 0.4 2.3 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase YHS PF04945.13 AIC15525.1 - 4.6e-05 23.4 0.1 0.00011 22.2 0.1 1.6 1 0 0 1 1 1 1 YHS domain HAD PF12710.7 AIC15525.1 - 6.2e-05 23.5 0.1 0.00029 21.3 0.1 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase ADH_zinc_N PF00107.26 AIC15525.1 - 0.0037 17.2 2.9 0.036 14.0 0.3 2.5 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Hydrolase_6 PF13344.6 AIC15525.1 - 0.0046 17.1 0.0 0.023 14.8 0.0 2.3 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase PIN_9 PF18477.1 AIC15525.1 - 0.065 13.5 0.4 0.22 11.9 0.4 1.9 1 0 0 1 1 1 0 PIN like domain HAD_2 PF13419.6 AIC15525.1 - 0.077 13.1 0.2 0.27 11.3 0.2 1.9 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF2116 PF09889.9 AIC15525.1 - 0.14 12.2 0.0 0.49 10.4 0.0 1.9 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Ntox34 PF15606.6 AIC15525.1 - 0.16 12.1 0.2 0.46 10.6 0.2 1.8 1 0 0 1 1 1 0 Bacterial toxin 34 zf-FCS PF06467.14 AIC15525.1 - 0.21 11.6 0.1 0.37 10.8 0.1 1.4 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif DUF4231 PF14015.6 AIC15525.1 - 0.91 10.0 0.0 0.91 10.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) GtrA PF04138.14 AIC15525.1 - 8.2 6.7 9.6 0.12 12.6 0.4 2.4 2 1 0 2 2 2 0 GtrA-like protein HMA PF00403.26 AIC15526.1 - 7.5e-13 48.7 0.4 9e-13 48.5 0.4 1.1 1 0 0 1 1 1 1 Heavy-metal-associated domain YHS PF04945.13 AIC15527.1 - 1e-12 47.9 0.3 1.2e-12 47.7 0.3 1.0 1 0 0 1 1 1 1 YHS domain DEAD PF00270.29 AIC15529.1 - 2.8e-53 180.3 0.0 1.7e-52 177.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIC15529.1 - 3.7e-33 114.2 0.1 4.3e-32 110.7 0.0 2.6 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIC15529.1 - 2.9e-05 24.1 0.0 5.6e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 AIC15529.1 - 6.3e-05 22.3 0.0 9.6e-05 21.7 0.0 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase AAA_30 PF13604.6 AIC15529.1 - 8e-05 22.4 0.3 0.41 10.3 0.0 2.3 2 0 0 2 2 2 2 AAA domain UTP25 PF06862.12 AIC15529.1 - 0.00018 20.5 0.0 0.3 9.8 0.0 2.7 2 1 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 AAA_19 PF13245.6 AIC15529.1 - 0.015 15.7 0.1 2.3 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain CMS1 PF14617.6 AIC15529.1 - 0.018 14.4 0.1 0.035 13.5 0.1 1.4 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Methyltr_RsmB-F PF01189.17 AIC15529.1 - 0.17 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Radical_SAM PF04055.21 AIC15532.1 - 1.5e-18 67.7 0.0 3.8e-18 66.4 0.0 1.7 1 1 1 2 2 2 1 Radical SAM superfamily SPASM PF13186.6 AIC15532.1 - 1.2e-08 35.3 1.4 3.2e-08 34.0 1.4 1.7 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_12 PF13353.6 AIC15532.1 - 7.3e-08 32.8 0.0 2e-07 31.4 0.0 1.7 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIC15532.1 - 7.9e-05 22.8 0.0 0.00024 21.2 0.0 1.9 1 0 0 1 1 1 1 4Fe-4S single cluster domain PqqD PF05402.12 AIC15533.1 - 6e-05 23.3 0.0 9.6e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) Radical_SAM PF04055.21 AIC15534.1 - 1e-19 71.6 0.1 1.7e-19 70.8 0.1 1.4 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 AIC15534.1 - 6.4e-05 23.2 0.0 0.00012 22.3 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain SPASM PF13186.6 AIC15534.1 - 0.0028 18.1 4.2 0.0059 17.1 4.2 1.6 1 0 0 1 1 1 1 Iron-sulfur cluster-binding domain Fer4_14 PF13394.6 AIC15534.1 - 0.054 13.6 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 4Fe-4S single cluster domain AAA_32 PF13654.6 AIC15534.1 - 0.11 11.3 0.0 0.18 10.5 0.0 1.3 1 1 0 1 1 1 0 AAA domain SnoaL_2 PF12680.7 AIC15535.1 - 1.1e-13 51.7 0.0 1.5e-13 51.3 0.0 1.1 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIC15535.1 - 1.4e-06 28.7 0.0 2e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4440) NTF2 PF02136.20 AIC15535.1 - 0.00036 21.1 0.0 0.00046 20.8 0.0 1.2 1 0 0 1 1 1 1 Nuclear transport factor 2 (NTF2) domain Fer4_7 PF12838.7 AIC15536.1 - 4.1e-12 46.5 22.9 4.2e-07 30.5 7.9 2.0 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4 PF00037.27 AIC15536.1 - 2.3e-11 43.0 13.1 3e-07 30.0 2.5 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 AIC15536.1 - 3.6e-07 30.2 3.4 5.6e-07 29.6 3.4 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIC15536.1 - 4.7e-07 29.8 2.6 0.016 15.3 0.1 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_10 PF13237.6 AIC15536.1 - 1e-06 28.7 5.5 1.7e-05 24.8 6.5 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIC15536.1 - 7.3e-06 26.3 1.0 0.11 13.0 0.0 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIC15536.1 - 1.3e-05 26.1 4.6 0.082 13.9 1.7 2.4 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_17 PF13534.6 AIC15536.1 - 1.5e-05 25.4 0.6 0.075 13.6 0.5 2.2 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIC15536.1 - 4.8e-05 23.3 13.1 0.0011 18.9 1.7 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 AIC15536.1 - 0.00017 21.8 4.9 0.22 12.1 0.2 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain ETF_QO PF05187.13 AIC15536.1 - 0.00046 20.3 0.1 0.00051 20.1 0.1 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S Fer4_3 PF12798.7 AIC15536.1 - 0.0009 20.0 11.5 0.08 13.9 1.0 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 AIC15536.1 - 0.0013 19.5 2.2 0.44 11.4 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIC15536.1 - 0.0055 16.7 10.4 0.068 13.3 0.8 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 AIC15536.1 - 0.021 15.4 8.4 0.13 12.8 0.5 2.2 2 0 0 2 2 2 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_18 PF13746.6 AIC15536.1 - 0.73 10.0 9.0 1.4 9.2 1.3 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_15 PF13459.6 AIC15536.1 - 0.89 10.3 12.1 51 4.7 12.1 2.3 1 1 0 1 1 1 0 4Fe-4S single cluster domain Diphthamide_syn PF01866.17 AIC15537.1 - 8.6e-60 202.7 0.0 1.1e-59 202.4 0.0 1.0 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Fe-ADH_2 PF13685.6 AIC15537.1 - 0.17 11.6 0.1 0.35 10.5 0.1 1.6 1 1 0 1 1 1 0 Iron-containing alcohol dehydrogenase Atx10homo_assoc PF09759.9 AIC15538.1 - 0.058 13.4 0.0 0.069 13.2 0.0 1.1 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain UbiD PF01977.16 AIC15541.1 - 2.3e-98 329.8 0.9 2.6e-98 329.6 0.9 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AbiEi_4 PF13338.6 AIC15541.1 - 0.13 12.4 0.1 2.6 8.3 0.0 2.5 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin HxlR PF01638.17 AIC15545.1 - 7.1e-25 86.7 0.1 9.2e-25 86.3 0.1 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 AIC15545.1 - 0.043 13.8 0.0 0.061 13.3 0.0 1.2 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family Atx10homo_assoc PF09759.9 AIC15545.1 - 0.16 12.1 0.0 0.22 11.6 0.0 1.4 1 0 0 1 1 1 0 Spinocerebellar ataxia type 10 protein domain EutH PF04346.12 AIC15546.1 - 0.00087 18.6 1.8 0.00097 18.4 1.8 1.0 1 0 0 1 1 1 1 Ethanolamine utilisation protein, EutH 2TM PF13239.6 AIC15546.1 - 1.3 9.3 8.0 4.2 7.7 0.1 3.0 2 1 1 3 3 3 0 2TM domain 5TM-5TMR_LYT PF07694.12 AIC15547.1 - 0.0039 16.7 0.6 0.0053 16.3 0.6 1.2 1 0 0 1 1 1 1 5TMR of 5TMR-LYT LEA_2 PF03168.13 AIC15547.1 - 0.012 16.1 0.1 0.033 14.7 0.0 1.9 2 1 0 2 2 2 0 Late embryogenesis abundant protein DUF5067 PF16729.5 AIC15547.1 - 0.023 14.6 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5067) Cas_Csm6 PF09659.10 AIC15547.1 - 0.051 12.3 0.0 0.065 12.0 0.0 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) CopD PF05425.13 AIC15548.1 - 6.8e-14 52.2 7.1 6.8e-14 52.2 7.1 1.6 2 0 0 2 2 2 1 Copper resistance protein D DUF4149 PF13664.6 AIC15548.1 - 0.0082 16.4 0.8 0.0082 16.4 0.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) Urate_ox_N PF06181.11 AIC15548.1 - 0.067 12.5 0.6 0.067 12.5 0.6 2.1 1 1 0 2 2 2 0 Urate oxidase N-terminal DUF1035 PF06281.12 AIC15548.1 - 0.81 9.7 4.8 0.17 11.9 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1035) RTC PF01137.21 AIC15549.1 - 1.7e-70 236.7 0.0 2.1e-70 236.4 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 AIC15549.1 - 5.5e-11 42.9 0.1 1.2e-10 41.8 0.1 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain Bac_luciferase PF00296.20 AIC15550.1 - 4.1e-55 187.4 0.0 5e-55 187.1 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase DUF4116 PF13475.6 AIC15551.1 - 0.11 12.2 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4116) Fic PF02661.18 AIC15552.1 - 5.5e-06 27.2 0.0 2.1e-05 25.3 0.0 1.8 2 0 0 2 2 2 1 Fic/DOC family CTP_transf_like PF01467.26 AIC15555.1 - 5.5e-14 52.6 6.0 8e-14 52.0 5.5 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like ParD_antitoxin PF03693.14 AIC15556.1 - 0.014 15.8 0.1 0.076 13.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH HHA PF05321.11 AIC15556.1 - 0.094 13.0 0.1 2.1 8.8 0.0 2.2 2 0 0 2 2 2 0 Haemolysin expression modulating protein Asparaginase PF00710.20 AIC15558.1 - 3.1e-59 199.7 0.9 5.6e-59 198.9 0.9 1.4 1 0 0 1 1 1 1 Asparaginase, N-terminal Asparaginase_C PF17763.1 AIC15558.1 - 1.5e-28 99.3 0.0 4.4e-28 97.8 0.0 1.8 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain GatD_N PF18195.1 AIC15558.1 - 4.8e-18 64.2 0.7 1e-17 63.1 0.7 1.6 1 0 0 1 1 1 1 GatD N-terminal domain GatB_N PF02934.15 AIC15559.1 - 1.1e-62 212.0 0.0 1.4e-62 211.6 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AIC15559.1 - 2.3e-20 73.0 3.3 2.3e-20 73.0 3.3 2.2 2 0 0 2 2 2 1 GatB domain GAD PF02938.14 AIC15559.1 - 1.1e-06 28.7 0.0 3.9e-06 27.0 0.0 1.9 1 0 0 1 1 1 1 GAD domain YqeY PF09424.10 AIC15559.1 - 0.00016 21.8 3.2 0.00028 21.0 2.3 1.9 1 1 0 1 1 1 1 Yqey-like protein Amdase PF17645.1 AIC15559.1 - 0.011 15.3 0.2 0.055 13.1 0.2 2.1 2 0 0 2 2 2 0 Arylmalonate decarboxylase FixG_C PF11614.8 AIC15564.1 - 0.0018 18.5 0.4 0.44 10.8 0.1 2.3 1 1 0 2 2 2 2 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF824 PF05688.11 AIC15564.1 - 0.0068 16.2 1.0 4.2 7.3 0.1 2.8 2 0 0 2 2 2 2 Salmonella repeat of unknown function (DUF824) DUF4232 PF14016.6 AIC15564.1 - 0.011 15.9 1.1 2.3 8.4 0.3 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF4232) NPCBM_assoc PF10633.9 AIC15564.1 - 0.059 13.6 3.9 2.2 8.6 0.4 3.6 3 1 0 3 3 3 0 NPCBM-associated, NEW3 domain of alpha-galactosidase fn3_5 PF06280.12 AIC15564.1 - 0.095 13.4 0.1 0.18 12.5 0.1 1.6 1 0 0 1 1 1 0 Fn3-like domain CPBP PF02517.16 AIC15566.1 - 6.5e-05 23.2 5.4 6.5e-05 23.2 5.4 1.7 2 0 0 2 2 2 1 CPBP intramembrane metalloprotease Gram_pos_anchor PF00746.21 AIC15566.1 - 0.16 11.9 0.2 0.16 11.9 0.2 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif HTH_34 PF13601.6 AIC15567.1 - 0.0002 21.5 0.0 0.0019 18.4 0.0 2.1 2 0 0 2 2 2 1 Winged helix DNA-binding domain HTH_45 PF14947.6 AIC15567.1 - 0.0054 16.7 0.0 0.013 15.5 0.0 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix HTH_27 PF13463.6 AIC15567.1 - 0.0082 16.6 0.1 0.019 15.4 0.0 1.7 2 0 0 2 2 2 1 Winged helix DNA-binding domain MarR PF01047.22 AIC15567.1 - 0.014 15.3 0.0 0.041 13.8 0.0 1.7 2 0 0 2 2 2 0 MarR family TrmB PF01978.19 AIC15567.1 - 0.016 15.1 0.1 0.039 13.8 0.1 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 AIC15567.1 - 0.016 15.1 0.0 0.029 14.2 0.0 1.5 1 0 0 1 1 1 0 MarR family Rio2_N PF09202.11 AIC15567.1 - 0.018 15.3 0.0 0.036 14.3 0.0 1.6 1 1 0 1 1 1 0 Rio2, N-terminal HTH_24 PF13412.6 AIC15567.1 - 0.063 12.8 0.0 0.14 11.7 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Mrr_N PF14338.6 AIC15567.1 - 0.13 12.4 0.0 0.36 11.0 0.0 1.8 2 1 0 2 2 2 0 Mrr N-terminal domain Rrf2 PF02082.20 AIC15567.1 - 0.13 12.6 0.1 0.4 11.1 0.0 1.8 2 0 0 2 2 2 0 Transcriptional regulator DUF1579 PF07617.11 AIC15568.1 - 0.038 13.9 0.1 0.28 11.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1579) Exo84_C PF16528.5 AIC15568.1 - 0.14 11.9 0.2 0.21 11.4 0.2 1.2 1 0 0 1 1 1 0 Exocyst component 84 C-terminal NurA PF09376.10 AIC15569.1 - 5.7e-07 29.5 0.2 2.2e-05 24.3 0.2 2.1 1 1 1 2 2 2 2 NurA domain DUF3475 PF11961.8 AIC15569.1 - 0.14 12.2 1.2 0.55 10.4 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) DUF87 PF01935.17 AIC15570.1 - 1.7e-07 31.6 0.0 4e-07 30.4 0.0 1.7 1 1 0 1 1 1 1 Helicase HerA, central domain AAA_22 PF13401.6 AIC15570.1 - 0.0014 18.9 0.0 0.18 12.0 0.0 2.5 2 0 0 2 2 2 1 AAA domain CLP1_P PF16575.5 AIC15570.1 - 0.024 14.4 0.0 0.042 13.6 0.0 1.3 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop CbiA PF01656.23 AIC15570.1 - 0.11 12.6 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_14 PF13173.6 AIC15570.1 - 0.12 12.4 0.0 0.45 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain RRM_occluded PF16842.5 AIC15570.1 - 0.13 12.1 0.0 0.41 10.5 0.0 1.9 1 0 0 1 1 1 0 Occluded RNA-recognition motif P-II PF00543.22 AIC15571.1 - 9.3e-22 77.6 1.0 1.1e-21 77.3 1.0 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II LTD PF00932.19 AIC15572.1 - 4.4e-17 62.5 0.2 9.5e-17 61.4 0.2 1.5 1 0 0 1 1 1 1 Lamin Tail Domain SNase PF00565.17 AIC15572.1 - 0.042 14.3 0.0 0.097 13.1 0.0 1.6 1 0 0 1 1 1 0 Staphylococcal nuclease homologue Phage_holin_3_6 PF07332.11 AIC15573.1 - 0.057 13.5 8.2 0.065 13.3 8.2 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4175 PF13779.6 AIC15573.1 - 0.62 7.9 5.3 0.64 7.9 5.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Trp_oprn_chp PF09534.10 AIC15573.1 - 2.2 8.1 7.8 2.5 7.9 7.8 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) ETRAMP PF09716.10 AIC15573.1 - 4.5 7.4 7.8 0.34 11.0 2.2 1.8 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Glycos_transf_4 PF00953.21 AIC15574.1 - 8.4e-27 94.1 14.4 8.4e-27 94.1 14.4 2.2 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF1467 PF07330.12 AIC15574.1 - 0.24 11.4 5.4 0.5 10.3 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) DEAD PF00270.29 AIC15575.1 - 5.4e-24 84.9 0.0 1.2e-23 83.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase HHH_5 PF14520.6 AIC15575.1 - 5.2e-10 39.8 2.6 1.1e-09 38.7 0.3 2.8 3 0 0 3 3 2 1 Helix-hairpin-helix domain Helicase_C PF00271.31 AIC15575.1 - 6.4e-10 39.4 0.0 7.5e-09 35.9 0.0 2.4 1 1 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIC15575.1 - 2.5e-06 27.6 0.0 2.2e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HHH_2 PF12826.7 AIC15575.1 - 0.00015 21.8 0.0 0.00055 20.0 0.0 2.0 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH PF00633.23 AIC15575.1 - 0.0016 18.2 2.9 0.6 10.1 0.1 3.4 3 0 0 3 3 3 2 Helix-hairpin-helix motif DNA_pol_lambd_f PF10391.9 AIC15575.1 - 0.0019 18.0 0.0 0.0048 16.7 0.0 1.6 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda AAA_34 PF13872.6 AIC15575.1 - 0.022 13.6 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 RecA PF00154.21 AIC15575.1 - 0.027 13.9 0.0 0.053 13.0 0.0 1.4 1 0 0 1 1 1 0 recA bacterial DNA recombination protein ATPase PF06745.13 AIC15575.1 - 0.043 13.1 0.0 0.11 11.9 0.0 1.5 1 0 0 1 1 1 0 KaiC ATPase_2 PF01637.18 AIC15575.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_26 PF13500.6 AIC15575.1 - 0.058 13.2 0.2 0.11 12.3 0.2 1.4 1 0 0 1 1 1 0 AAA domain DUF4157 PF13699.6 AIC15576.1 - 0.027 14.7 0.0 0.047 13.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) MCM PF00493.23 AIC15577.1 - 7e-93 309.8 0.0 1e-92 309.3 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 AIC15577.1 - 1.6e-36 125.0 0.1 2.6e-36 124.2 0.1 1.3 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 AIC15577.1 - 1.5e-22 79.8 0.6 2.7e-22 79.0 0.6 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 AIC15577.1 - 5.6e-16 59.0 3.4 1.6e-15 57.6 1.6 2.3 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 AIC15577.1 - 1.3e-06 28.0 0.1 0.00028 20.3 0.0 2.6 2 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 AIC15577.1 - 1.3e-06 28.4 0.0 1.2e-05 25.3 0.0 2.6 3 1 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AIC15577.1 - 0.0014 18.5 0.0 0.0052 16.6 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DHquinase_I PF01487.15 AIC15577.1 - 0.038 14.2 0.2 0.11 12.7 0.0 1.7 2 0 0 2 2 2 0 Type I 3-dehydroquinase AAA_30 PF13604.6 AIC15577.1 - 0.058 13.1 0.5 0.36 10.5 0.3 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AIC15577.1 - 0.074 13.4 0.8 1.4 9.3 0.0 3.0 3 1 1 4 4 4 0 AAA ATPase domain AAA PF00004.29 AIC15577.1 - 0.13 12.6 0.0 0.39 11.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zn-ribbon_8 PF09723.10 AIC15577.1 - 0.21 11.7 0.3 0.44 10.7 0.3 1.5 1 0 0 1 1 1 0 Zinc ribbon domain Sld5 PF05916.11 AIC15578.1 - 1.6e-06 28.5 0.1 2.2e-06 28.1 0.1 1.2 1 0 0 1 1 1 1 GINS complex protein Porin_5 PF16930.5 AIC15578.1 - 0.051 12.1 0.1 0.052 12.0 0.1 1.1 1 0 0 1 1 1 0 Putative porin DNA_pol3_delta2 PF13177.6 AIC15579.1 - 1.9e-15 57.0 0.1 1.6e-13 50.7 0.1 2.3 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 AIC15579.1 - 7.1e-14 52.4 0.0 1.4e-13 51.4 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rep_fac_C PF08542.11 AIC15579.1 - 1.3e-08 35.1 0.5 5.9e-08 33.0 0.0 2.4 3 0 0 3 3 1 1 Replication factor C C-terminal domain Rad17 PF03215.15 AIC15579.1 - 5.9e-08 32.9 0.0 1.1e-07 31.9 0.0 1.6 1 1 0 1 1 1 1 Rad17 P-loop domain RuvB_N PF05496.12 AIC15579.1 - 7.5e-07 29.0 0.1 3.2e-06 27.0 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_14 PF13173.6 AIC15579.1 - 1.8e-05 24.8 0.0 3.2e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC15579.1 - 0.00011 22.7 0.0 0.0012 19.3 0.0 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 AIC15579.1 - 0.00013 22.3 0.4 0.0066 16.7 0.4 2.5 1 1 0 1 1 1 1 AAA domain DEAD PF00270.29 AIC15579.1 - 0.0002 21.2 0.3 0.081 12.7 0.0 2.4 1 1 1 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 AIC15579.1 - 0.0002 21.4 0.0 0.0013 18.7 0.0 2.0 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Mg_chelatase PF01078.21 AIC15579.1 - 0.00033 20.1 0.0 0.081 12.3 0.0 2.4 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_assoc_2 PF16193.5 AIC15579.1 - 0.00041 20.6 0.1 0.001 19.4 0.1 1.8 1 0 0 1 1 1 1 AAA C-terminal domain AAA_24 PF13479.6 AIC15579.1 - 0.00054 19.7 0.0 0.001 18.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 AIC15579.1 - 0.005 15.9 0.1 0.015 14.3 0.1 1.8 1 1 1 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DNA_pol3_delta PF06144.13 AIC15579.1 - 0.007 16.2 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA_30 PF13604.6 AIC15579.1 - 0.0087 15.8 0.1 0.029 14.1 0.1 1.9 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 AIC15579.1 - 0.012 15.7 0.0 0.037 14.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_19 PF13245.6 AIC15579.1 - 0.013 15.8 0.4 0.65 10.3 0.4 2.4 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AIC15579.1 - 0.015 14.5 0.0 0.034 13.3 0.0 1.7 1 1 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 AIC15579.1 - 0.015 15.2 0.0 0.13 12.2 0.0 2.0 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea TIP49 PF06068.13 AIC15579.1 - 0.025 13.8 0.0 0.067 12.4 0.0 1.7 1 1 1 2 2 2 0 TIP49 P-loop domain Sigma54_activat PF00158.26 AIC15579.1 - 0.03 14.0 0.2 0.36 10.5 0.1 2.4 2 1 0 2 2 1 0 Sigma-54 interaction domain AAA_5 PF07728.14 AIC15579.1 - 0.034 14.1 0.2 0.11 12.4 0.2 1.8 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AIC15579.1 - 0.1 13.2 0.0 0.23 12.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 AIC15579.1 - 0.16 11.7 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NTPase_1 PF03266.15 AIC15579.1 - 0.19 11.6 1.0 2.3 8.1 0.1 2.2 1 1 1 2 2 2 0 NTPase zinc_ribbon_10 PF10058.9 AIC15580.1 - 0.00053 19.7 0.3 0.00097 18.8 0.3 1.4 1 1 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein zinc_ribbon_4 PF13717.6 AIC15580.1 - 0.00089 19.1 0.6 0.19 11.7 0.2 2.2 2 0 0 2 2 2 1 zinc-ribbon domain CpXC PF14353.6 AIC15580.1 - 0.0077 16.3 1.2 0.29 11.2 0.1 2.2 1 1 1 2 2 2 1 CpXC protein zf-ribbon_3 PF13248.6 AIC15580.1 - 0.012 15.0 0.9 0.49 9.9 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIC15580.1 - 0.012 15.5 0.1 0.024 14.6 0.1 1.5 1 1 0 1 1 1 0 Putative transposase DNA-binding domain C1_1 PF00130.22 AIC15580.1 - 0.014 15.3 0.3 0.021 14.7 0.3 1.3 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HypA PF01155.19 AIC15580.1 - 0.018 15.1 0.6 0.026 14.5 0.4 1.5 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA tRNA-synt_1f PF01921.18 AIC15580.1 - 0.021 13.8 0.0 0.025 13.5 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) zf-H2C2_2 PF13465.6 AIC15580.1 - 0.031 14.7 1.3 3.8 8.1 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain Zn-ribbon_8 PF09723.10 AIC15580.1 - 0.052 13.7 2.2 0.052 13.7 2.2 2.0 2 1 0 2 2 1 0 Zinc ribbon domain TF_Zn_Ribbon PF08271.12 AIC15580.1 - 0.052 13.1 5.6 2.6 7.6 0.0 2.9 2 1 0 2 2 2 0 TFIIB zinc-binding Elf1 PF05129.13 AIC15580.1 - 0.064 13.3 1.2 8.5 6.5 0.0 1.9 1 1 1 2 2 2 0 Transcription elongation factor Elf1 like Nudix_N_2 PF14803.6 AIC15580.1 - 0.066 13.1 1.1 4.3 7.3 0.2 2.2 2 0 0 2 2 2 0 Nudix N-terminal zf-C2H2 PF00096.26 AIC15580.1 - 0.069 13.6 1.2 15 6.3 0.0 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type TFIIS_C PF01096.18 AIC15580.1 - 0.089 12.7 2.0 4 7.4 0.2 2.3 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) zf-C2H2_12 PF18658.1 AIC15580.1 - 0.094 12.3 0.1 0.23 11.0 0.1 1.6 1 1 1 2 2 2 0 Zinc-finger C2H2-type C1_2 PF03107.16 AIC15580.1 - 0.1 13.0 0.7 2.3 8.6 0.0 2.2 1 1 1 2 2 2 0 C1 domain ADK_lid PF05191.14 AIC15580.1 - 0.12 12.4 0.8 0.25 11.4 0.8 1.5 1 1 0 1 1 1 0 Adenylate kinase, active site lid zf-Mss51 PF13824.6 AIC15580.1 - 0.14 12.3 2.3 0.3 11.2 2.3 1.8 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Prim_Zn_Ribbon PF08273.12 AIC15580.1 - 0.15 12.4 2.1 8.2 6.8 0.5 2.2 2 0 0 2 2 2 0 Zinc-binding domain of primase-helicase zf-C2H2_6 PF13912.6 AIC15580.1 - 0.24 11.4 4.8 5.7 7.1 1.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2_4 PF13894.6 AIC15580.1 - 0.42 11.6 2.7 19 6.4 0.3 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HE PF16278.5 AIC15580.1 - 0.71 10.4 4.1 0.81 10.2 0.2 2.5 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3 PF13878.6 AIC15580.1 - 0.76 9.7 2.7 14 5.6 0.2 2.3 1 1 1 2 2 2 0 zinc-finger of acetyl-transferase ESCO zinc_ribbon_5 PF13719.6 AIC15580.1 - 0.86 9.4 4.3 0.85 9.4 0.9 2.2 2 1 0 2 2 2 0 zinc-ribbon domain Pirin PF02678.16 AIC15581.1 - 9.3e-37 125.3 0.3 3.4e-36 123.5 0.1 1.9 2 0 0 2 2 2 1 Pirin Pirin_C PF05726.13 AIC15581.1 - 3.1e-34 117.4 0.1 2.4e-32 111.4 0.0 2.9 3 0 0 3 3 3 1 Pirin C-terminal cupin domain Cupin_2 PF07883.11 AIC15581.1 - 2.4e-08 33.6 4.7 0.00057 19.6 0.2 2.4 2 0 0 2 2 2 2 Cupin domain Cupin_3 PF05899.12 AIC15581.1 - 0.00043 19.9 1.0 0.41 10.4 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF861) Patatin PF01734.22 AIC15582.1 - 1.9e-24 87.0 0.0 4.2e-24 85.9 0.0 1.6 1 1 0 1 1 1 1 Patatin-like phospholipase DUF3734 PF12536.8 AIC15582.1 - 9.3e-06 25.9 0.4 3.6e-05 24.0 0.4 2.0 1 1 0 1 1 1 1 Patatin phospholipase PWWP PF00855.17 AIC15582.1 - 0.0049 17.2 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 PWWP domain PseudoU_synth_2 PF00849.22 AIC15582.1 - 0.15 12.1 0.2 0.26 11.4 0.2 1.4 1 0 0 1 1 1 0 RNA pseudouridylate synthase FTR1 PF03239.14 AIC15583.1 - 1.1e-19 70.8 31.5 4.5e-17 62.2 17.4 3.1 3 1 1 4 4 4 2 Iron permease FTR1 family MFS_MOT1 PF16983.5 AIC15583.1 - 4.5 7.7 7.7 0.29 11.6 1.5 2.2 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Ribosomal_S7 PF00177.21 AIC15584.1 - 5.4e-39 133.2 2.0 8.6e-39 132.6 2.0 1.3 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e Ribosom_S12_S23 PF00164.25 AIC15585.1 - 9.2e-49 163.8 0.1 1.1e-48 163.5 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein S12/S23 KH_2 PF07650.17 AIC15586.1 - 3.2e-21 74.9 1.2 4.2e-14 52.1 0.1 2.1 2 0 0 2 2 2 2 KH domain KH_5 PF13184.6 AIC15586.1 - 1.4e-11 44.3 4.0 4.6e-10 39.4 0.3 2.2 2 0 0 2 2 2 2 NusA-like KH domain KH_4 PF13083.6 AIC15586.1 - 8.4e-11 41.6 1.1 0.0002 21.1 0.1 2.2 2 0 0 2 2 2 2 KH domain KH_1 PF00013.29 AIC15586.1 - 1.8e-08 34.1 0.8 4e-06 26.6 0.1 2.5 1 1 1 2 2 2 2 KH domain Polbeta PF18765.1 AIC15586.1 - 0.02 15.0 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase Ribosomal_L7Ae PF01248.26 AIC15587.1 - 2.7e-10 39.9 1.9 3.1e-10 39.6 1.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNA_pol_Rpb1_1 PF04997.12 AIC15588.1 - 9.4e-95 317.5 0.0 2.6e-94 316.1 0.0 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_5 PF04998.17 AIC15588.1 - 2.7e-86 289.3 0.7 5e-86 288.4 0.7 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 AIC15588.1 - 7.3e-73 244.3 0.0 1.6e-72 243.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 AIC15588.1 - 3.7e-33 114.7 0.0 8e-33 113.6 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_4 PF05000.17 AIC15588.1 - 6.4e-25 87.2 0.0 1.6e-24 85.9 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 Bystin PF05291.11 AIC15588.1 - 0.042 13.1 0.2 0.65 9.2 0.0 2.6 2 1 1 3 3 3 0 Bystin zf-RING_7 PF02591.15 AIC15588.1 - 0.17 12.1 0.5 28 5.0 0.1 2.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain Fer4_17 PF13534.6 AIC15588.1 - 1 10.0 2.6 35 5.0 0.1 2.5 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF35_N PF12172.8 AIC15588.1 - 9.1 6.3 6.9 97 3.0 0.1 3.5 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) RNA_pol_Rpb2_6 PF00562.28 AIC15589.1 - 6.2e-123 410.7 0.1 8.9e-123 410.2 0.1 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_1 PF04563.15 AIC15589.1 - 1e-40 139.4 0.0 1.8e-40 138.6 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_7 PF04560.20 AIC15589.1 - 8.8e-33 112.6 0.4 1.9e-32 111.5 0.4 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 RNA_pol_Rpb2_3 PF04565.16 AIC15589.1 - 2.2e-28 98.2 0.1 4.4e-28 97.3 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_2 PF04561.14 AIC15589.1 - 3.1e-21 75.9 0.0 5.9e-21 75.0 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_4 PF04566.13 AIC15589.1 - 1.2e-18 67.1 0.1 2.7e-18 66.0 0.1 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_5 PF04567.17 AIC15589.1 - 3.7e-09 37.0 0.2 9.7e-09 35.7 0.2 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 DUF2318 PF10080.9 AIC15589.1 - 0.029 14.5 0.4 0.063 13.4 0.4 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) FYVE PF01363.21 AIC15589.1 - 0.031 14.4 0.4 0.06 13.5 0.4 1.4 1 0 0 1 1 1 0 FYVE zinc finger FYVE_2 PF02318.16 AIC15589.1 - 0.093 13.0 0.1 0.18 12.0 0.1 1.4 1 0 0 1 1 1 0 FYVE-type zinc finger Zn_Tnp_IS1595 PF12760.7 AIC15589.1 - 0.13 12.3 0.2 0.27 11.3 0.2 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIC15589.1 - 0.25 11.3 1.9 0.4 10.6 0.9 1.9 2 0 0 2 2 1 0 Putative transposase DNA-binding domain TF_Zn_Ribbon PF08271.12 AIC15589.1 - 1.5 8.4 3.1 8.5 6.0 0.3 2.6 1 1 1 2 2 2 0 TFIIB zinc-binding RNA_pol_Rpb5_C PF01191.19 AIC15590.1 - 8.7e-28 96.0 0.3 1e-27 95.8 0.3 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain MG2 PF01835.19 AIC15591.1 - 0.0017 18.8 0.2 0.0078 16.6 0.2 2.2 1 1 0 1 1 1 1 MG2 domain Ribosomal_S4e PF00900.20 AIC15591.1 - 0.01 15.7 0.1 0.024 14.5 0.1 1.6 1 0 0 1 1 1 0 Ribosomal family S4e DUF1264 PF06884.11 AIC15592.1 - 1.2e-25 90.0 0.0 1.7e-25 89.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1264) DUF5547 PF17701.1 AIC15592.1 - 0.093 12.6 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5547) CcmF_C PF16327.5 AIC15592.1 - 0.13 11.5 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal NIF3 PF01784.18 AIC15593.1 - 2.4e-08 33.9 2.8 8.9e-07 28.8 2.8 2.1 1 1 0 1 1 1 1 NIF3 (NGG1p interacting factor 3) ADH_zinc_N PF00107.26 AIC15593.1 - 0.043 13.8 0.3 0.19 11.7 0.3 2.1 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Glycos_transf_N PF04413.16 AIC15593.1 - 0.063 12.9 0.0 0.093 12.4 0.0 1.3 1 0 0 1 1 1 0 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) Wyosine_form PF08608.12 AIC15594.1 - 1.5e-19 70.1 0.0 3.5e-19 68.9 0.0 1.7 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 AIC15594.1 - 1.9e-18 67.4 0.1 7e-18 65.6 0.1 1.8 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 AIC15594.1 - 0.0093 16.1 0.1 1 9.5 0.0 2.5 2 0 0 2 2 2 2 4Fe-4S single cluster domain Ham1p_like PF01725.16 AIC15595.1 - 2.4e-46 158.0 0.0 2.7e-46 157.9 0.0 1.0 1 0 0 1 1 1 1 Ham1 family APH PF01636.23 AIC15596.1 - 2e-09 37.7 2.0 9.3e-06 25.7 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase PF00069.25 AIC15596.1 - 7.6e-06 25.5 0.0 2.9e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain RIO1 PF01163.22 AIC15596.1 - 2.5e-05 24.0 0.0 4.2e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 AIC15596.1 - 5.9e-05 22.5 0.0 0.00015 21.2 0.0 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 AIC15596.1 - 0.0081 15.5 0.0 0.015 14.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Choline_kinase PF01633.20 AIC15596.1 - 0.02 14.5 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_Tyr PF07714.17 AIC15596.1 - 0.031 13.6 0.0 0.045 13.0 0.0 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase EcKinase PF02958.20 AIC15596.1 - 0.19 11.0 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Ecdysteroid kinase bPH_3 PF14470.6 AIC15597.1 - 6.5e-05 23.2 0.1 0.00011 22.5 0.1 1.4 1 1 0 1 1 1 1 Bacterial PH domain Peptidase_M22 PF00814.25 AIC15598.1 - 5.5e-78 262.4 0.0 6.6e-78 262.1 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 AIC15598.1 - 0.073 12.7 0.1 0.76 9.4 0.0 2.3 2 1 0 2 2 2 0 Carbamoyltransferase N-terminus MMR_HSR1_C PF08438.10 AIC15599.1 - 7.6e-30 103.8 0.1 1.4e-29 102.9 0.1 1.4 1 0 0 1 1 1 1 GTPase of unknown function C-terminal MMR_HSR1 PF01926.23 AIC15599.1 - 1.6e-20 73.3 0.0 9.6e-20 70.8 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase TGS PF02824.21 AIC15599.1 - 7.7e-14 51.5 0.1 4.4e-13 49.1 0.1 2.1 2 0 0 2 2 2 1 TGS domain FeoB_N PF02421.18 AIC15599.1 - 7.4e-07 28.8 0.1 3.2e-06 26.7 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B YchF-GTPase_C PF06071.13 AIC15599.1 - 0.01 16.0 0.1 0.055 13.7 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF933) AAA_29 PF13555.6 AIC15599.1 - 0.019 14.7 0.0 0.04 13.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain VF530 PF09905.9 AIC15599.1 - 0.029 14.5 0.0 0.091 13.0 0.0 1.7 2 0 0 2 2 2 0 DNA-binding protein VF530 SicP-binding PF09119.10 AIC15599.1 - 0.069 13.1 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 SicP binding Cupin_5 PF06172.11 AIC15600.1 - 3.6e-46 156.9 0.0 4.1e-46 156.6 0.0 1.0 1 0 0 1 1 1 1 Cupin superfamily (DUF985) QueC PF06508.13 AIC15601.1 - 8.1e-52 175.8 0.2 9.3e-52 175.6 0.2 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 AIC15601.1 - 0.0002 21.1 0.0 0.00032 20.5 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase Arginosuc_synth PF00764.19 AIC15601.1 - 0.018 14.4 0.0 0.022 14.0 0.0 1.2 1 0 0 1 1 1 0 Arginosuccinate synthase Fer4_14 PF13394.6 AIC15602.1 - 8.6e-13 48.5 0.1 1.4e-12 47.7 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 AIC15602.1 - 1.1e-11 45.2 0.2 1.9e-11 44.4 0.1 1.4 1 1 0 1 1 1 1 4Fe-4S single cluster domain Radical_SAM PF04055.21 AIC15602.1 - 2.6e-11 44.2 0.3 3.6e-11 43.7 0.3 1.2 1 0 0 1 1 1 1 Radical SAM superfamily zf-C2HE PF16278.5 AIC15602.1 - 0.17 12.4 0.8 20 5.7 0.0 2.4 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger GTP_cyclohydroI PF01227.22 AIC15603.1 - 1.6e-61 206.8 0.1 1.9e-61 206.6 0.1 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 AIC15603.1 - 0.0099 16.0 0.0 0.021 15.0 0.0 1.5 1 0 0 1 1 1 1 QueF-like protein PepSY PF03413.19 AIC15604.1 - 5.7e-05 23.6 2.1 0.00042 20.8 2.1 2.0 1 1 0 1 1 1 1 Peptidase propeptide and YPEB domain AAA PF00004.29 AIC15606.1 - 3.8e-16 59.7 0.2 1.7e-15 57.6 0.0 2.2 3 0 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 AIC15606.1 - 2.8e-06 27.4 0.0 5.9e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC15606.1 - 3.4e-06 27.6 0.1 0.00012 22.5 0.0 3.0 3 1 1 4 4 3 1 AAA ATPase domain AAA_5 PF07728.14 AIC15606.1 - 2.1e-05 24.5 0.0 6.3e-05 23.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 AIC15606.1 - 7.1e-05 22.8 0.0 0.00013 22.0 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_7 PF12775.7 AIC15606.1 - 8.2e-05 22.2 0.0 0.00017 21.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 AIC15606.1 - 9.1e-05 22.8 0.0 0.0012 19.1 0.0 2.5 2 1 1 3 3 3 1 AAA domain RuvB_N PF05496.12 AIC15606.1 - 0.00017 21.4 0.0 0.0004 20.2 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 AIC15606.1 - 0.00029 20.5 0.0 0.00062 19.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIC15606.1 - 0.00085 19.9 0.0 0.0016 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 AIC15606.1 - 0.00085 19.9 0.0 0.0017 18.9 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 AIC15606.1 - 0.0013 18.9 0.0 0.0029 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 AIC15606.1 - 0.0015 18.4 0.0 0.27 11.1 0.0 2.4 2 0 0 2 2 2 1 NACHT domain TIP49 PF06068.13 AIC15606.1 - 0.002 17.4 0.0 0.0041 16.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_8 PF12780.7 AIC15606.1 - 0.003 16.9 0.0 0.0051 16.2 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 IstB_IS21 PF01695.17 AIC15606.1 - 0.0039 16.9 0.0 0.0077 16.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein DUF815 PF05673.13 AIC15606.1 - 0.0042 16.3 0.0 0.0067 15.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_17 PF13207.6 AIC15606.1 - 0.0043 17.5 0.0 0.0092 16.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 AIC15606.1 - 0.0045 16.4 0.0 0.0095 15.3 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AIC15606.1 - 0.0087 16.3 0.0 0.018 15.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 AIC15606.1 - 0.011 15.7 0.0 0.048 13.6 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 AIC15606.1 - 0.012 16.0 0.0 0.028 14.8 0.0 1.7 1 1 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 AIC15606.1 - 0.014 15.4 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 NTPase AAA_3 PF07726.11 AIC15606.1 - 0.026 14.4 0.1 0.085 12.7 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 AIC15606.1 - 0.031 14.0 0.1 0.13 12.0 0.0 2.0 2 0 0 2 2 1 0 AAA domain AAA_19 PF13245.6 AIC15606.1 - 0.035 14.4 0.0 0.098 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_2 PF07724.14 AIC15606.1 - 0.045 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) Zeta_toxin PF06414.12 AIC15606.1 - 0.049 12.9 0.0 0.09 12.0 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 AIC15606.1 - 0.051 13.6 0.0 0.094 12.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 AIC15606.1 - 0.055 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 AIC15606.1 - 0.098 12.7 0.0 0.25 11.4 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase Roc PF08477.13 AIC15606.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SRP54 PF00448.22 AIC15606.1 - 0.13 11.9 0.0 0.23 11.0 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_11 PF13086.6 AIC15606.1 - 0.17 11.6 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AIC15606.1 - 0.18 11.0 0.0 0.36 10.0 0.0 1.5 1 0 0 1 1 1 0 NB-ARC domain zf-PARP PF00645.18 AIC15607.1 - 0.019 15.8 0.9 0.019 15.8 0.9 1.9 2 0 0 2 2 2 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region zf-HC5HC2H_2 PF13832.6 AIC15607.1 - 0.038 14.1 13.3 0.1 12.8 13.1 1.7 1 1 1 2 2 2 0 PHD-zinc-finger like domain ProRS-C_1 PF09180.11 AIC15607.1 - 0.069 13.4 3.9 3.9 7.8 1.0 2.6 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal DUF2911 PF11138.8 AIC15607.1 - 0.074 12.9 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2911) FBA_3 PF08268.12 AIC15607.1 - 0.11 12.4 0.3 0.16 11.9 0.3 1.2 1 0 0 1 1 1 0 F-box associated domain tRNA-synt_1g PF09334.11 AIC15607.1 - 0.48 9.1 2.2 0.61 8.8 2.2 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (M) zf-HC5HC2H PF13771.6 AIC15607.1 - 0.79 10.0 15.4 0.2 12.0 10.2 2.1 1 1 1 2 2 2 0 PHD-like zinc-binding domain FAM35_C PF15793.5 AIC15607.1 - 1.7 8.0 7.9 0.7 9.3 4.2 1.9 1 1 1 2 2 2 0 Protein family FAM35, C-terminal CIAPIN1 PF05093.13 AIC15607.1 - 9.4 6.8 14.4 12 6.4 12.6 2.0 1 1 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Vps5 PF09325.10 AIC15608.1 - 0.084 12.4 0.1 0.093 12.3 0.1 1.0 1 0 0 1 1 1 0 Vps5 C terminal like Carboxyl_trans PF01039.22 AIC15609.1 - 2.7e-187 623.3 0.3 3.1e-187 623.1 0.3 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 AIC15609.1 - 1e-05 25.2 0.0 2.9e-05 23.7 0.0 1.7 2 0 0 2 2 2 1 Malonate decarboxylase gamma subunit (MdcE) CPSase_L_D2 PF02786.17 AIC15610.1 - 2.5e-74 249.3 0.0 4e-74 248.7 0.0 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_N PF00289.22 AIC15610.1 - 3.5e-47 159.5 0.3 2.6e-46 156.7 0.1 2.3 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_carb_C PF02785.19 AIC15610.1 - 3.5e-37 126.8 0.0 7.1e-37 125.8 0.0 1.5 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain Dala_Dala_lig_C PF07478.13 AIC15610.1 - 6.8e-08 32.3 0.1 2.4e-07 30.5 0.0 1.9 2 1 0 2 2 2 1 D-ala D-ala ligase C-terminus RimK PF08443.11 AIC15610.1 - 6.9e-08 32.3 0.0 0.00012 21.8 0.0 2.3 2 0 0 2 2 2 2 RimK-like ATP-grasp domain ATP-grasp PF02222.22 AIC15610.1 - 5.1e-07 29.4 0.0 1.1e-06 28.4 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATP-grasp_3 PF02655.14 AIC15610.1 - 4.5e-05 23.6 0.0 0.00034 20.7 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_ST PF14397.6 AIC15610.1 - 0.0054 16.0 0.1 0.076 12.3 0.1 2.4 3 0 0 3 3 3 1 Sugar-transfer associated ATP-grasp Spore_IV_A PF09547.10 AIC15610.1 - 0.083 11.8 0.0 0.14 11.1 0.0 1.3 1 0 0 1 1 1 0 Stage IV sporulation protein A (spore_IV_A) Biotin_lipoyl PF00364.22 AIC15611.1 - 2.1e-16 59.5 4.2 2.9e-16 59.0 2.8 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme Biotin_lipoyl_2 PF13533.6 AIC15611.1 - 9.1e-13 47.8 3.1 1.4e-08 34.4 0.2 2.5 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_D23 PF16576.5 AIC15611.1 - 0.0008 18.7 0.3 0.22 10.7 0.1 2.2 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion GCV_H PF01597.19 AIC15611.1 - 0.0047 16.8 0.7 0.011 15.6 0.4 1.8 2 0 0 2 2 2 1 Glycine cleavage H-protein PASTA PF03793.19 AIC15611.1 - 0.0057 16.5 0.3 0.018 14.9 0.2 2.0 2 0 0 2 2 2 1 PASTA domain HlyD_3 PF13437.6 AIC15611.1 - 0.013 16.1 1.0 6.1 7.6 0.0 2.8 3 1 0 3 3 3 0 HlyD family secretion protein DUF2118 PF09891.9 AIC15611.1 - 0.071 13.1 0.4 0.3 11.1 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) SH3_2 PF07653.17 AIC15611.1 - 0.08 12.6 0.1 0.78 9.5 0.0 2.4 2 0 0 2 2 2 0 Variant SH3 domain DUF4013 PF13197.6 AIC15612.1 - 1.8 8.4 18.4 11 5.9 14.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4013) Lactamase_B_2 PF12706.7 AIC15613.1 - 1e-09 38.2 2.9 1.8e-09 37.4 2.9 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIC15613.1 - 7.2e-06 26.0 0.0 9.3e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain AhpC-TSA PF00578.21 AIC15614.1 - 2.5e-38 130.8 0.0 3.3e-38 130.4 0.0 1.1 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC15614.1 - 2.4e-27 95.5 0.0 2.9e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Redoxin SCO1-SenC PF02630.14 AIC15614.1 - 0.0012 18.8 0.0 0.0021 18.0 0.0 1.5 1 1 0 1 1 1 1 SCO1/SenC AhpC-TSA_2 PF13911.6 AIC15614.1 - 0.022 14.9 0.0 1.6 8.9 0.0 2.2 1 1 1 2 2 2 0 AhpC/TSA antioxidant enzyme CAP_assoc_N PF14504.6 AIC15614.1 - 0.037 13.8 0.0 0.073 12.8 0.0 1.6 2 0 0 2 2 2 0 CAP-associated N-terminal TraF PF13728.6 AIC15614.1 - 0.089 12.6 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein Aminotran_5 PF00266.19 AIC15615.1 - 8e-90 301.5 0.0 9.8e-90 301.2 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AIC15615.1 - 0.00016 21.0 0.0 0.00022 20.6 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 AIC15615.1 - 0.00062 19.2 0.1 0.001 18.5 0.1 1.3 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Cys_Met_Meta_PP PF01053.20 AIC15615.1 - 0.083 11.4 0.0 0.12 10.9 0.0 1.3 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme QueC PF06508.13 AIC15616.1 - 8.8e-11 41.7 0.0 4.2e-09 36.2 0.0 2.5 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 AIC15616.1 - 1.1e-08 35.2 0.0 1.4e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 AIC15616.1 - 3.5e-08 32.9 0.0 8.2e-08 31.7 0.0 1.5 2 0 0 2 2 2 1 NAD synthase tRNA_Me_trans PF03054.16 AIC15616.1 - 7.4e-08 31.6 0.1 5.7e-06 25.4 0.0 2.2 2 0 0 2 2 2 2 tRNA methyl transferase ATP_bind_3 PF01171.20 AIC15616.1 - 0.00015 21.6 0.1 0.0007 19.4 0.1 2.0 1 1 1 2 2 2 1 PP-loop family ThiI PF02568.14 AIC15616.1 - 0.0006 19.5 0.0 0.0012 18.5 0.0 1.5 1 1 0 1 1 1 1 Thiamine biosynthesis protein (ThiI) Arginosuc_synth PF00764.19 AIC15616.1 - 0.0027 17.1 0.1 0.0036 16.6 0.1 1.3 1 0 0 1 1 1 1 Arginosuccinate synthase AAA_33 PF13671.6 AIC15616.1 - 0.026 14.7 0.0 0.095 12.9 0.0 1.9 1 1 1 2 2 2 0 AAA domain Yippee-Mis18 PF03226.14 AIC15616.1 - 0.083 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly PAPS_reduct PF01507.19 AIC15616.1 - 0.17 11.9 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family DUF4432 PF14486.6 AIC15616.1 - 0.19 10.5 0.0 0.25 10.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4432) DUF111 PF01969.17 AIC15617.1 - 1.1e-105 353.8 2.4 1.3e-105 353.6 2.4 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF111 HypA PF01155.19 AIC15618.1 - 0.07 13.2 0.1 0.087 12.8 0.1 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA CbtA PF09490.10 AIC15621.1 - 2.4e-15 57.0 28.9 5.7e-15 55.7 28.9 1.5 1 1 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) Tail_VII PF17091.5 AIC15621.1 - 0.064 13.1 0.9 0.064 13.1 0.9 2.8 2 0 0 2 2 2 0 Inovirus G7P protein COX6C PF02937.15 AIC15621.1 - 0.22 11.7 0.0 0.22 11.7 0.0 2.8 3 1 0 3 3 3 0 Cytochrome c oxidase subunit VIc TRAPP PF04051.16 AIC15621.1 - 0.22 11.2 0.1 20 4.9 0.0 2.2 2 0 0 2 2 2 0 Transport protein particle (TRAPP) component DUF998 PF06197.13 AIC15621.1 - 2.1 7.9 24.8 0.052 13.1 3.9 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF998) Yip1 PF04893.17 AIC15621.1 - 4.3 7.0 22.7 3.3 7.4 9.1 2.4 1 1 1 2 2 2 0 Yip1 domain HU-CCDC81_bac_2 PF18175.1 AIC15622.1 - 0.0077 16.1 0.1 0.0099 15.7 0.1 1.2 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 Toxin_9 PF02819.15 AIC15623.1 - 0.0022 18.2 3.8 0.0028 17.9 3.8 1.2 1 0 0 1 1 1 1 Spider toxin TruB_N PF01509.18 AIC15624.1 - 4.4e-24 85.5 0.9 1.8e-15 57.6 0.0 3.2 1 1 1 2 2 2 2 TruB family pseudouridylate synthase (N terminal domain) TruB_C_2 PF16198.5 AIC15624.1 - 2.9e-19 68.9 0.1 6.5e-19 67.8 0.1 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain PUA PF01472.20 AIC15624.1 - 3e-14 52.7 0.6 6.1e-14 51.7 0.6 1.5 1 0 0 1 1 1 1 PUA domain DKCLD PF08068.12 AIC15624.1 - 6.9e-13 48.5 0.0 1.3e-12 47.6 0.0 1.5 1 0 0 1 1 1 1 DKCLD (NUC011) domain SmaI PF17411.2 AIC15624.1 - 0.01 15.0 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Type II site-specific deoxyribonuclease Cytidylate_kin2 PF13189.6 AIC15625.1 - 5.9e-15 55.8 0.0 9.3e-15 55.2 0.0 1.3 1 0 0 1 1 1 1 Cytidylate kinase-like family AAA_18 PF13238.6 AIC15625.1 - 1.4e-11 45.0 0.0 2.1e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 AIC15625.1 - 3.7e-07 30.6 0.2 9.8e-07 29.3 0.2 1.7 1 1 0 1 1 1 1 AAA domain Cytidylate_kin PF02224.18 AIC15625.1 - 0.00086 19.1 0.1 0.16 11.7 0.0 2.1 1 1 1 2 2 2 2 Cytidylate kinase KTI12 PF08433.10 AIC15625.1 - 0.0046 16.5 0.0 0.0064 16.0 0.0 1.4 1 1 0 1 1 1 1 Chromatin associated protein KTI12 RNA_helicase PF00910.22 AIC15625.1 - 0.01 16.2 0.0 0.014 15.8 0.0 1.3 1 0 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 AIC15625.1 - 0.014 15.8 0.0 0.015 15.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 AIC15625.1 - 0.019 15.2 0.1 0.036 14.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 AIC15625.1 - 0.02 15.3 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 AIC15625.1 - 0.031 14.5 0.0 0.065 13.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain ADK PF00406.22 AIC15625.1 - 0.038 14.1 0.1 0.097 12.8 0.0 1.7 2 0 0 2 2 2 0 Adenylate kinase SKI PF01202.22 AIC15625.1 - 0.16 12.1 0.5 2 8.5 0.5 2.3 1 1 0 1 1 1 0 Shikimate kinase Hydin_ADK PF17213.3 AIC15625.1 - 0.17 12.2 0.0 0.29 11.4 0.0 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain EMC3_TMCO1 PF01956.16 AIC15626.1 - 1.3e-11 44.5 13.8 2.9e-11 43.4 11.8 2.1 1 1 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like RSN1_TM PF13967.6 AIC15626.1 - 0.0069 16.2 0.2 0.19 11.5 0.0 2.3 2 0 0 2 2 2 1 Late exocytosis, associated with Golgi transport CLN3 PF02487.17 AIC15626.1 - 0.027 13.5 0.5 0.037 13.1 0.5 1.1 1 0 0 1 1 1 0 CLN3 protein KCH PF16944.5 AIC15626.1 - 0.036 13.8 1.0 0.055 13.2 0.1 1.7 2 0 0 2 2 2 0 Fungal potassium channel DUF996 PF06195.13 AIC15626.1 - 0.24 11.7 2.8 1.2 9.5 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF996) SUIM_assoc PF16619.5 AIC15626.1 - 2.3 8.4 5.6 0.35 11.0 0.4 1.9 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AAA_17 PF13207.6 AIC15627.1 - 1.6e-32 112.8 0.1 1.9e-32 112.5 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIC15627.1 - 9.7e-09 35.9 0.0 1.5e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 AIC15627.1 - 2e-05 24.3 0.4 3.5e-05 23.5 0.4 1.4 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_33 PF13671.6 AIC15627.1 - 4e-05 23.8 0.0 5.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AIC15627.1 - 0.00018 21.8 0.3 0.0003 21.1 0.3 1.5 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIC15627.1 - 0.00038 20.2 0.2 0.0006 19.6 0.2 1.4 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 AIC15627.1 - 0.001 18.6 0.0 0.0013 18.3 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_22 PF13401.6 AIC15627.1 - 0.001 19.3 0.2 0.0027 18.0 0.2 1.7 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 AIC15627.1 - 0.0021 18.1 0.2 0.019 15.0 0.1 2.1 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) ResIII PF04851.15 AIC15627.1 - 0.003 17.6 0.5 0.008 16.2 0.5 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 AIC15627.1 - 0.0031 17.8 1.4 0.0079 16.5 1.4 1.7 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 AIC15627.1 - 0.0042 17.0 1.5 0.011 15.7 1.5 1.7 1 1 0 1 1 1 1 NTPase AAA_16 PF13191.6 AIC15627.1 - 0.014 15.8 0.1 0.016 15.6 0.1 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 AIC15627.1 - 0.016 15.6 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MeaB PF03308.16 AIC15627.1 - 0.017 14.1 0.1 0.024 13.6 0.1 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Viral_helicase1 PF01443.18 AIC15627.1 - 0.018 14.8 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 AIC15627.1 - 0.019 14.3 0.1 0.045 13.1 0.1 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI cobW PF02492.19 AIC15627.1 - 0.023 14.3 0.1 0.098 12.2 0.1 1.9 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 AIC15627.1 - 0.036 13.8 0.2 0.069 12.9 0.2 1.6 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 AIC15627.1 - 0.04 13.7 0.3 0.35 10.6 0.1 2.3 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein MMR_HSR1 PF01926.23 AIC15627.1 - 0.046 13.8 0.6 0.12 12.5 0.5 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF2075 PF09848.9 AIC15627.1 - 0.056 12.7 0.0 0.063 12.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 AIC15627.1 - 0.072 13.0 0.0 0.11 12.4 0.0 1.3 1 1 0 1 1 1 0 NACHT domain Thymidylate_kin PF02223.17 AIC15627.1 - 0.11 12.2 0.5 0.45 10.2 0.5 2.1 1 1 0 1 1 1 0 Thymidylate kinase RNA_helicase PF00910.22 AIC15627.1 - 0.15 12.4 0.0 0.31 11.5 0.0 1.6 1 1 1 2 2 2 0 RNA helicase Roc PF08477.13 AIC15627.1 - 0.17 12.1 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SecY PF00344.20 AIC15628.1 - 1.7e-63 214.7 14.4 2.2e-63 214.4 14.4 1.1 1 0 0 1 1 1 1 SecY translocase Plug_translocon PF10559.9 AIC15628.1 - 9.9e-13 47.7 0.6 9.9e-13 47.7 0.6 2.1 2 0 0 2 2 2 1 Plug domain of Sec61p Ribosomal_L27A PF00828.19 AIC15629.1 - 2.9e-15 57.1 1.6 4.5e-15 56.4 1.6 1.3 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ribosomal_L18 PF17135.4 AIC15629.1 - 0.025 14.0 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein 60S L18 and 50S L18e Ribosomal_L30 PF00327.20 AIC15630.1 - 5.8e-12 45.3 0.0 1.1e-11 44.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L30p/L7e Ribosomal_S5 PF00333.20 AIC15631.1 - 6.6e-22 77.3 2.1 1.7e-21 76.0 1.5 1.9 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 AIC15631.1 - 1.2e-17 63.2 0.1 1.7e-17 62.6 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_L5e PF17144.4 AIC15632.1 - 8.1e-13 48.7 6.1 2.5e-12 47.1 0.2 3.1 3 1 1 4 4 4 2 Ribosomal large subunit proteins 60S L5, and 50S L18 Ribosomal_L18_c PF14204.6 AIC15632.1 - 2.7e-09 37.8 9.2 2.7e-09 37.8 9.2 1.9 2 0 0 2 2 2 1 Ribosomal L18 C-terminal region FliD_C PF07195.12 AIC15632.1 - 0.0071 15.8 0.0 0.014 14.8 0.0 1.4 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus Ribosomal_L18p PF00861.22 AIC15632.1 - 0.015 15.7 0.1 0.015 15.7 0.1 1.8 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast AIRC PF00731.20 AIC15633.1 - 1e-15 57.6 8.0 1e-15 57.6 8.0 1.7 2 0 0 2 2 2 1 AIR carboxylase YscJ_FliF PF01514.17 AIC15633.1 - 0.0016 18.2 0.3 0.0029 17.3 0.3 1.4 1 0 0 1 1 1 1 Secretory protein of YscJ/FliF family RRF PF01765.19 AIC15633.1 - 0.0084 16.1 0.2 0.013 15.5 0.2 1.3 1 0 0 1 1 1 1 Ribosome recycling factor adh_short PF00106.25 AIC15633.1 - 0.013 14.9 3.7 0.024 14.1 3.7 1.4 1 0 0 1 1 1 0 short chain dehydrogenase Band_7_1 PF13421.6 AIC15633.1 - 0.071 12.8 0.2 0.12 12.1 0.2 1.3 1 0 0 1 1 1 0 SPFH domain-Band 7 family VbhA PF18495.1 AIC15633.1 - 0.071 13.0 0.1 0.19 11.6 0.1 1.7 1 0 0 1 1 1 0 Antitoxin VbhA AF0941-like PF14591.6 AIC15633.1 - 0.076 13.6 0.2 0.26 11.9 0.1 1.8 1 1 1 2 2 2 0 AF0941-like Ldh_1_N PF00056.23 AIC15634.1 - 2e-36 125.2 0.9 2e-36 125.2 0.9 1.9 2 0 0 2 2 2 1 lactate/malate dehydrogenase, NAD binding domain Ldh_1_C PF02866.18 AIC15634.1 - 5.8e-24 84.9 0.1 8.6e-24 84.3 0.1 1.2 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Glyco_hydro_4 PF02056.16 AIC15634.1 - 0.016 14.7 0.4 0.1 12.1 0.1 2.1 1 1 1 2 2 2 0 Family 4 glycosyl hydrolase UDPG_MGDP_dh_N PF03721.14 AIC15634.1 - 0.05 13.2 1.6 0.077 12.6 0.6 1.8 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain YcaO PF02624.16 AIC15636.1 - 1.5e-76 257.8 0.1 1.8e-37 129.4 0.0 2.0 1 1 0 2 2 2 2 YcaO cyclodehydratase, ATP-ad Mg2+-binding TfuA PF07812.12 AIC15637.1 - 2.2e-34 117.7 0.0 3.7e-34 117.0 0.0 1.4 1 0 0 1 1 1 1 TfuA-like protein Cob_adeno_trans PF01923.18 AIC15638.1 - 1.8e-53 181.1 0.0 2e-53 180.9 0.0 1.0 1 0 0 1 1 1 1 Cobalamin adenosyltransferase COA2 PF17051.5 AIC15639.1 - 0.075 13.1 0.1 0.086 12.9 0.1 1.1 1 0 0 1 1 1 0 Cytochrome C oxidase assembly factor 2 zf-C2H2 PF00096.26 AIC15640.1 - 7.6e-06 26.1 0.8 9e-06 25.9 0.8 1.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC15640.1 - 2e-05 25.0 0.2 2.6e-05 24.7 0.2 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-Di19 PF05605.12 AIC15640.1 - 3.4e-05 24.1 0.1 4e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 AIC15640.1 - 0.00084 19.6 0.1 0.00084 19.6 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 AIC15640.1 - 0.0031 17.3 0.1 0.0035 17.2 0.1 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (1 copy) zf-H2C2_2 PF13465.6 AIC15640.1 - 0.0051 17.2 3.0 0.65 10.5 0.3 2.1 2 0 0 2 2 2 2 Zinc-finger double domain HNH PF01844.23 AIC15640.1 - 0.0074 16.4 0.3 0.0086 16.2 0.3 1.2 1 0 0 1 1 1 1 HNH endonuclease zf-CHCC PF10276.9 AIC15640.1 - 0.0082 16.2 0.1 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 Zinc-finger domain Rad50_zn_hook PF04423.14 AIC15640.1 - 0.01 15.7 0.1 0.012 15.4 0.1 1.2 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-BED PF02892.15 AIC15640.1 - 0.011 15.8 0.1 0.014 15.4 0.1 1.2 1 0 0 1 1 1 0 BED zinc finger DUF2225 PF09986.9 AIC15640.1 - 0.014 15.1 0.0 0.014 15.1 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-ribbon_3 PF13248.6 AIC15640.1 - 0.016 14.6 0.2 0.027 13.9 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-C2H2_jaz PF12171.8 AIC15640.1 - 0.017 15.4 0.1 0.02 15.2 0.1 1.2 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding DUF4187 PF13821.6 AIC15640.1 - 0.02 14.7 0.1 0.025 14.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) zf-C2H2_3rep PF18868.1 AIC15640.1 - 0.032 14.9 0.0 0.032 14.9 0.0 1.0 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats zinc_ribbon_9 PF14369.6 AIC15640.1 - 0.046 14.0 0.1 0.072 13.4 0.1 1.3 1 0 0 1 1 1 0 zinc-ribbon zinc_ribbon_5 PF13719.6 AIC15640.1 - 0.11 12.3 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 zinc-ribbon domain TRAF6_Z2 PF18048.1 AIC15640.1 - 0.13 12.3 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 zf-H2C2_5 PF13909.6 AIC15640.1 - 0.25 11.2 4.9 1.3 8.8 4.9 2.0 1 1 0 1 1 1 0 C2H2-type zinc-finger domain HD_3 PF13023.6 AIC15641.1 - 1e-36 126.3 0.1 1.2e-36 126.1 0.1 1.1 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 AIC15641.1 - 6.5e-14 52.1 0.1 8.8e-14 51.7 0.1 1.3 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 AIC15641.1 - 0.0019 18.4 1.2 0.0097 16.1 1.2 2.0 1 1 0 1 1 1 1 HD domain DUF1958 PF09211.10 AIC15642.1 - 0.074 13.4 0.0 2.8 8.3 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1958) Saccharop_dh_N PF04455.12 AIC15643.1 - 1.9e-35 121.2 0.0 5.3e-35 119.8 0.0 1.8 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region DS PF01916.17 AIC15643.1 - 0.013 14.8 0.1 0.15 11.3 0.1 2.3 1 1 1 2 2 2 0 Deoxyhypusine synthase Band_7 PF01145.25 AIC15644.1 - 1.7e-33 116.1 7.7 2.6e-33 115.5 7.7 1.3 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 AIC15644.1 - 0.00017 21.4 0.8 0.00036 20.3 0.8 1.6 1 0 0 1 1 1 1 SPFH domain-Band 7 family Tyr_Deacylase PF02580.16 AIC15644.1 - 0.0097 16.4 0.1 0.033 14.7 0.0 2.0 2 0 0 2 2 2 1 D-Tyr-tRNA(Tyr) deacylase DUF3040 PF11239.8 AIC15644.1 - 8.1 6.8 7.0 17 5.8 7.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) SelR PF01641.18 AIC15645.1 - 1.8e-52 176.5 0.5 2.1e-52 176.3 0.5 1.0 1 0 0 1 1 1 1 SelR domain HECT_2 PF09814.9 AIC15645.1 - 0.00032 19.7 1.1 0.076 11.9 0.4 2.0 1 1 0 2 2 2 2 HECT-like Ubiquitin-conjugating enzyme (E2)-binding TF_Zn_Ribbon PF08271.12 AIC15645.1 - 0.0013 18.2 1.3 0.26 10.8 0.1 2.6 2 0 0 2 2 2 2 TFIIB zinc-binding Izumo-Ig PF16706.5 AIC15645.1 - 0.0033 17.5 0.0 0.0059 16.6 0.0 1.3 1 0 0 1 1 1 1 Izumo-like Immunoglobulin domain Yippee-Mis18 PF03226.14 AIC15645.1 - 0.0039 17.4 0.0 0.0071 16.5 0.0 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly GFA PF04828.14 AIC15645.1 - 0.018 15.4 0.6 4.9 7.6 0.2 2.2 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Tnp_zf-ribbon_2 PF13842.6 AIC15645.1 - 0.045 14.6 0.5 12 6.8 0.0 2.4 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon zf-C2HC5 PF06221.13 AIC15645.1 - 0.088 12.8 0.9 0.57 10.2 0.1 2.2 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type DUF678 PF05077.12 AIC15645.1 - 0.095 12.8 0.2 1.1 9.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF678) zf-ribbon_3 PF13248.6 AIC15645.1 - 0.11 11.9 2.6 4.9 6.7 0.0 2.8 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_10 PF10058.9 AIC15645.1 - 0.12 12.1 1.6 12 5.7 0.3 2.4 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein DZR PF12773.7 AIC15645.1 - 0.31 11.1 4.6 4.4 7.4 4.6 2.5 1 1 0 1 1 1 0 Double zinc ribbon zf-HIT PF04438.16 AIC15645.1 - 0.42 10.5 0.3 0.42 10.5 0.3 2.6 2 1 0 2 2 2 0 HIT zinc finger zinc_ribbon_2 PF13240.6 AIC15645.1 - 2.9 7.7 8.5 7.7 6.4 0.1 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-C2HC_2 PF13913.6 AIC15647.1 - 0.05 13.5 0.0 0.05 13.5 0.0 2.0 2 0 0 2 2 2 0 zinc-finger of a C2HC-type RNA_pol_N PF01194.17 AIC15647.1 - 0.072 13.4 0.5 0.08 13.2 0.5 1.3 1 1 0 1 1 1 0 RNA polymerases N / 8 kDa subunit YHS PF04945.13 AIC15648.1 - 2.9e-09 36.9 1.4 3e-09 36.8 1.4 1.0 1 0 0 1 1 1 1 YHS domain Arc_trans_TRASH PF08394.10 AIC15648.1 - 0.0033 17.7 0.3 0.0034 17.7 0.3 1.2 1 0 0 1 1 1 1 Archaeal TRASH domain Rad50_zn_hook PF04423.14 AIC15648.1 - 0.064 13.1 0.7 0.083 12.7 0.7 1.2 1 0 0 1 1 1 0 Rad50 zinc hook motif PadR PF03551.14 AIC15649.1 - 3.7e-14 52.4 0.0 7.9e-14 51.4 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family RTP PF02334.16 AIC15649.1 - 1.9e-05 25.2 0.0 3.8e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Replication terminator protein TrmB PF01978.19 AIC15649.1 - 0.01 15.7 0.0 0.068 13.1 0.0 2.3 2 1 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_45 PF14947.6 AIC15649.1 - 0.014 15.4 0.2 0.04 13.9 0.1 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix DUF4423 PF14394.6 AIC15649.1 - 0.038 13.7 0.0 0.071 12.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) SMC_Nse1 PF07574.13 AIC15649.1 - 0.054 13.4 0.0 0.094 12.6 0.0 1.4 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex HTH_IclR PF09339.10 AIC15649.1 - 0.077 12.8 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain GatB_N PF02934.15 AIC15650.1 - 5.4e-96 321.2 0.0 7.1e-96 320.8 0.0 1.1 1 0 0 1 1 1 1 GatB/GatE catalytic domain GatB_Yqey PF02637.18 AIC15650.1 - 2.8e-33 114.9 2.9 4.5e-33 114.2 2.9 1.3 1 0 0 1 1 1 1 GatB domain SpoVIF PF14069.6 AIC15650.1 - 0.12 12.1 0.1 3.8 7.3 0.0 2.5 2 1 0 2 2 2 0 Stage VI sporulation protein F PSDC PF12588.8 AIC15650.1 - 0.18 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Phophatidylserine decarboxylase Amidase PF01425.21 AIC15651.1 - 2.3e-155 518.0 0.1 2.6e-155 517.8 0.1 1.0 1 0 0 1 1 1 1 Amidase Glu-tRNAGln PF02686.15 AIC15652.1 - 2.3e-06 27.8 0.0 3e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Glu-tRNAGln amidotransferase C subunit NPR1_like_C PF12313.8 AIC15652.1 - 0.027 14.0 0.2 0.029 13.9 0.2 1.1 1 0 0 1 1 1 0 NPR1/NIM1 like defence protein C terminal Methyltransf_1N PF02870.15 AIC15652.1 - 0.1 13.4 0.0 0.17 12.8 0.0 1.4 1 0 0 1 1 1 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain tRNA-synt_2 PF00152.20 AIC15653.1 - 6.5e-84 281.7 0.0 8e-84 281.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AIC15653.1 - 1.3e-13 50.7 0.1 2.7e-13 49.7 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 AIC15653.1 - 0.0033 16.9 0.1 0.0094 15.5 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) sCache_3_2 PF17203.4 AIC15653.1 - 0.026 14.7 0.0 0.056 13.6 0.0 1.5 1 0 0 1 1 1 0 Single cache domain 3 DsbD PF02683.15 AIC15655.1 - 6.5e-57 192.8 14.7 2.7e-56 190.8 14.7 1.9 1 1 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region AhpC-TSA PF00578.21 AIC15655.1 - 7e-24 84.1 0.0 1.1e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC15655.1 - 4.1e-22 78.5 0.0 6.7e-22 77.8 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 AIC15655.1 - 6.7e-12 45.6 0.0 4.8e-11 42.8 0.0 2.2 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin PF00085.20 AIC15655.1 - 6.4e-05 22.9 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin GSHPx PF00255.19 AIC15655.1 - 0.00013 21.5 0.0 0.00023 20.7 0.0 1.3 1 0 0 1 1 1 1 Glutathione peroxidase SCO1-SenC PF02630.14 AIC15655.1 - 0.019 14.9 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 SCO1/SenC DUF4064 PF13273.6 AIC15655.1 - 0.049 13.9 0.4 0.049 13.9 0.4 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF4064) BNR_2 PF13088.6 AIC15656.1 - 9.7e-10 38.2 0.1 1.1e-05 24.9 0.0 3.4 2 1 0 3 3 3 2 BNR repeat-like domain BNR PF02012.20 AIC15656.1 - 3.2e-06 26.3 8.0 0.46 10.7 0.1 5.4 5 0 0 5 5 5 3 BNR/Asp-box repeat BNR_4 PF15892.5 AIC15656.1 - 0.0051 16.2 3.8 0.53 9.6 0.1 3.8 2 2 0 3 3 3 2 BNR repeat-containing family member PSII_BNR PF14870.6 AIC15656.1 - 0.081 12.2 1.3 6.1 6.0 0.0 3.1 3 2 0 3 3 3 0 Photosynthesis system II assembly factor YCF48 PQQ_3 PF13570.6 AIC15656.1 - 0.23 12.0 1.2 4.3 8.0 0.1 3.4 3 0 0 3 3 3 0 PQQ-like domain HcyBio PF01837.16 AIC15658.1 - 0.15 10.9 0.0 0.16 10.7 0.0 1.0 1 0 0 1 1 1 0 Homocysteine biosynthesis enzyme, sulfur-incorporation DHHA1 PF02272.19 AIC15659.1 - 2.6e-05 24.6 3.7 4.7e-05 23.8 3.3 1.7 1 1 0 1 1 1 1 DHHA1 domain tRNA_SAD PF07973.14 AIC15659.1 - 0.015 15.3 0.2 0.036 14.2 0.2 1.7 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain YusW PF14039.6 AIC15659.1 - 0.096 13.2 0.0 0.4 11.2 0.0 2.1 1 1 0 1 1 1 0 YusW-like protein HTH_20 PF12840.7 AIC15660.1 - 2.1e-06 27.7 1.7 5.6e-06 26.3 0.3 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain DUF1724 PF08350.10 AIC15660.1 - 9.4e-05 22.5 0.0 0.00016 21.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1724) MarR_2 PF12802.7 AIC15660.1 - 0.0001 22.1 0.9 0.00023 21.0 0.2 1.9 2 0 0 2 2 2 1 MarR family HTH_5 PF01022.20 AIC15660.1 - 0.011 15.6 0.3 0.037 13.9 0.0 2.0 2 1 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.6 AIC15660.1 - 0.012 15.6 0.7 0.092 12.7 0.1 2.4 2 0 0 2 2 2 0 Crp-like helix-turn-helix domain TxDE PF18711.1 AIC15660.1 - 0.028 14.5 0.6 0.085 13.0 0.0 2.1 3 0 0 3 3 3 0 Toxoflavin-degrading enzyme HTH_24 PF13412.6 AIC15660.1 - 0.053 13.1 0.0 0.12 11.9 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding CarboxypepD_reg PF13620.6 AIC15661.1 - 5.3e-09 36.2 0.1 1.3e-08 34.9 0.1 1.7 1 0 0 1 1 1 1 Carboxypeptidase regulatory-like domain Aph-1 PF06105.12 AIC15662.1 - 0.029 13.8 1.7 0.033 13.6 1.7 1.3 1 1 0 1 1 1 0 Aph-1 protein DUF1297 PF06973.12 AIC15663.1 - 2e-74 249.2 0.0 2.6e-74 248.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.12 AIC15663.1 - 6.1e-29 100.5 0.0 8.6e-29 100.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1246) CPSase_L_D2 PF02786.17 AIC15663.1 - 0.015 14.8 0.0 0.024 14.1 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain YtkA PF13115.6 AIC15664.1 - 0.026 15.1 0.1 0.12 13.0 0.1 2.1 2 0 0 2 2 2 0 YtkA-like DUF1129 PF06570.11 AIC15664.1 - 0.21 11.1 2.7 0.34 10.4 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) EMP24_GP25L PF01105.24 AIC15664.1 - 5.5 6.9 6.1 0.48 10.3 0.1 2.2 3 0 0 3 3 3 0 emp24/gp25L/p24 family/GOLD TrbC PF04956.13 AIC15667.1 - 0.13 12.5 2.4 0.58 10.4 0.3 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family HTH_24 PF13412.6 AIC15668.1 - 1.6e-15 56.3 0.1 1.2e-06 27.9 0.0 2.3 2 0 0 2 2 2 2 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 AIC15668.1 - 1.4e-14 53.7 0.2 1e-10 41.3 0.0 2.3 2 0 0 2 2 2 2 Bacterial regulatory protein, arsR family MarR_2 PF12802.7 AIC15668.1 - 3.8e-11 42.7 0.5 2e-06 27.6 0.0 2.2 2 0 0 2 2 2 2 MarR family HTH_20 PF12840.7 AIC15668.1 - 8.2e-09 35.4 0.2 0.00077 19.5 0.0 2.3 2 0 0 2 2 2 2 Helix-turn-helix domain HTH_IclR PF09339.10 AIC15668.1 - 5.8e-07 29.2 0.7 0.0011 18.7 0.0 2.3 2 0 0 2 2 2 2 IclR helix-turn-helix domain MarR PF01047.22 AIC15668.1 - 2.6e-06 27.3 0.1 0.072 13.0 0.0 2.2 2 0 0 2 2 2 2 MarR family HTH_34 PF13601.6 AIC15668.1 - 2.3e-05 24.5 0.0 0.1 12.8 0.0 2.2 2 0 0 2 2 2 2 Winged helix DNA-binding domain TrmB PF01978.19 AIC15668.1 - 0.00017 21.4 0.0 0.0036 17.1 0.0 2.3 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB LexA_DNA_bind PF01726.16 AIC15668.1 - 0.00018 21.2 0.2 0.17 11.6 0.0 2.7 2 1 0 2 2 2 2 LexA DNA binding domain Rrf2 PF02082.20 AIC15668.1 - 0.00033 20.9 0.1 0.033 14.5 0.0 2.2 2 0 0 2 2 2 1 Transcriptional regulator HTH_Crp_2 PF13545.6 AIC15668.1 - 0.00087 19.2 0.1 0.023 14.7 0.0 2.4 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_40 PF14493.6 AIC15668.1 - 0.0035 17.7 0.0 0.009 16.5 0.0 1.7 1 1 1 2 2 2 1 Helix-turn-helix domain DprA_WH PF17782.1 AIC15668.1 - 0.0065 16.6 0.2 0.5 10.5 0.0 3.0 2 2 0 2 2 2 1 DprA winged helix domain Penicillinase_R PF03965.16 AIC15668.1 - 0.012 15.9 0.1 0.11 12.9 0.0 2.4 2 2 1 3 3 3 0 Penicillinase repressor Cdc6_C PF09079.11 AIC15668.1 - 0.014 15.4 0.1 0.48 10.4 0.0 2.6 2 0 0 2 2 2 0 CDC6, C terminal winged helix domain Sulfolobus_pRN PF05584.11 AIC15668.1 - 0.016 15.2 0.0 0.051 13.6 0.0 1.8 2 0 0 2 2 2 0 Sulfolobus plasmid regulatory protein RP-C PF03428.13 AIC15668.1 - 0.018 14.7 0.1 0.54 9.9 0.0 2.1 2 0 0 2 2 2 0 Replication protein C N-terminal domain baeRF_family10 PF18854.1 AIC15668.1 - 0.033 14.4 0.1 0.082 13.2 0.0 1.6 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 RepL PF05732.11 AIC15668.1 - 0.057 12.9 0.0 0.12 11.8 0.0 1.5 2 0 0 2 2 2 0 Firmicute plasmid replication protein (RepL) Fe_dep_repress PF01325.19 AIC15668.1 - 0.061 13.5 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_DeoR PF08220.12 AIC15668.1 - 0.073 12.8 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain HTH_38 PF13936.6 AIC15668.1 - 0.11 12.3 0.2 0.32 10.8 0.0 2.0 2 0 0 2 2 1 0 Helix-turn-helix domain MASE3 PF17159.4 AIC15669.1 - 0.012 15.3 6.5 0.012 15.3 6.5 1.6 1 1 1 2 2 2 0 Membrane-associated sensor domain Arteri_Gl PF00951.18 AIC15669.1 - 0.2 11.5 4.0 0.28 11.0 4.0 1.4 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein DUF2070 PF09843.9 AIC15669.1 - 0.23 9.7 6.7 0.26 9.5 6.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4229 PF14012.6 AIC15669.1 - 6 7.1 9.1 0.34 11.0 2.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4229) CopD PF05425.13 AIC15670.1 - 1.2e-18 67.5 8.5 1.2e-18 67.5 8.5 4.3 4 1 0 4 4 4 2 Copper resistance protein D CopC PF04234.12 AIC15670.1 - 7e-10 39.8 0.0 1.5e-09 38.8 0.0 1.6 1 0 0 1 1 1 1 CopC domain YtkA PF13115.6 AIC15670.1 - 0.0032 18.0 1.1 0.011 16.3 0.0 2.3 2 0 0 2 2 2 1 YtkA-like Invasin_D3 PF09134.10 AIC15670.1 - 0.17 12.2 1.2 9.9 6.5 0.2 2.4 2 0 0 2 2 2 0 Invasin, domain 3 Peptidase_U4 PF03419.13 AIC15670.1 - 5 6.3 10.3 16 4.7 10.1 1.9 1 1 0 1 1 1 0 Sporulation factor SpoIIGA CopC PF04234.12 AIC15672.1 - 2.6e-16 60.4 0.2 7.7e-16 58.9 0.2 1.9 1 0 0 1 1 1 1 CopC domain SGL PF08450.12 AIC15672.1 - 4.5e-13 49.4 0.0 0.0008 19.1 0.0 4.2 2 1 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region CopD PF05425.13 AIC15672.1 - 2.5e-10 40.7 6.3 2.5e-10 40.7 6.3 3.8 3 1 1 4 4 4 1 Copper resistance protein D Reg_prop PF07494.11 AIC15672.1 - 1.5e-06 27.7 11.5 3.6 8.1 0.0 7.6 9 0 0 9 9 9 3 Two component regulator propeller DUF4149 PF13664.6 AIC15672.1 - 3.6e-05 24.0 3.1 3.6e-05 24.0 3.1 2.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4149) YtkA PF13115.6 AIC15672.1 - 0.005 17.4 0.0 0.02 15.5 0.0 2.0 2 0 0 2 2 2 1 YtkA-like SBBP PF06739.11 AIC15672.1 - 0.013 15.5 0.5 9.5 6.3 0.0 4.1 4 0 0 4 4 4 0 Beta-propeller repeat Nup214_FG PF18617.1 AIC15672.1 - 1.7 9.2 5.8 0.25 11.9 0.6 2.2 2 0 0 2 2 2 0 Nucleoporin Nup214 phenylalanine-glycine (FG) domain LPG_synthase_TM PF03706.13 AIC15673.1 - 0.0092 15.6 9.9 0.011 15.3 9.9 1.0 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region Phage_holin_3_6 PF07332.11 AIC15673.1 - 1.4 9.0 10.5 2.3 8.3 4.1 2.1 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III NB PF04159.13 AIC15673.1 - 5.3 7.1 6.4 1.8 8.7 0.2 2.6 1 1 1 2 2 2 0 NB glycoprotein Diphthamide_syn PF01866.17 AIC15674.1 - 0.013 15.0 0.5 0.013 15.0 0.5 1.1 1 0 0 1 1 1 0 Putative diphthamide synthesis protein DUF2721 PF11026.8 AIC15674.1 - 0.025 14.5 1.7 0.026 14.4 1.3 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) DUF3395 PF11875.8 AIC15674.1 - 0.027 14.4 2.7 0.058 13.3 2.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3395) DUF3498 PF12004.8 AIC15674.1 - 0.03 13.5 1.5 0.029 13.6 1.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) LPP PF04728.13 AIC15674.1 - 0.094 13.1 3.8 5.3 7.5 0.1 2.3 2 1 0 2 2 2 0 Lipoprotein leucine-zipper FlaC_arch PF05377.11 AIC15674.1 - 0.16 12.4 4.8 3 8.3 1.8 2.2 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Bap31_Bap29_C PF18035.1 AIC15674.1 - 5.7 7.0 9.3 0.46 10.5 2.9 1.9 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain EspB PF05802.11 AIC15675.1 - 0.00073 19.6 3.0 0.00073 19.6 3.0 1.6 2 0 0 2 2 2 1 Enterobacterial EspB protein Alanine_zipper PF11839.8 AIC15675.1 - 0.0095 16.3 6.8 0.019 15.3 6.8 1.4 1 0 0 1 1 1 1 Alanine-zipper, major outer membrane lipoprotein OspD PF03207.13 AIC15675.1 - 0.025 14.0 1.0 0.035 13.4 1.0 1.2 1 0 0 1 1 1 0 Borrelia outer surface protein D (OspD) DUF948 PF06103.11 AIC15675.1 - 0.2 11.9 0.3 0.2 11.9 0.3 2.7 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) LPP PF04728.13 AIC15675.1 - 0.95 9.9 9.2 5.3 7.5 9.2 2.1 1 1 0 1 1 1 0 Lipoprotein leucine-zipper PPC PF04151.15 AIC15676.1 - 0.0031 18.6 0.1 0.0056 17.7 0.1 1.4 1 0 0 1 1 1 1 Bacterial pre-peptidase C-terminal domain Filamin PF00630.19 AIC15676.1 - 0.01 16.7 0.0 0.015 16.1 0.0 1.3 1 0 0 1 1 1 0 Filamin/ABP280 repeat PorA PF11271.8 AIC15676.1 - 0.058 12.7 0.0 0.058 12.7 0.0 1.4 2 0 0 2 2 2 0 Porin PorA NMO PF03060.15 AIC15676.1 - 0.068 12.5 0.7 0.08 12.3 0.0 1.4 2 0 0 2 2 2 0 Nitronate monooxygenase Big_3_5 PF16640.5 AIC15676.1 - 0.15 12.3 1.4 15 5.9 0.0 3.0 3 1 1 4 4 4 0 Bacterial Ig-like domain (group 3) ETRAMP PF09716.10 AIC15677.1 - 0.23 11.6 0.7 4 7.6 0.0 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Cupredoxin_1 PF13473.6 AIC15678.1 - 6.5e-10 39.0 1.7 3e-07 30.5 0.0 3.0 2 2 0 2 2 2 2 Cupredoxin-like domain Copper-bind PF00127.20 AIC15678.1 - 2.7e-08 34.2 0.5 4e-06 27.2 0.0 2.5 2 1 0 2 2 2 1 Copper binding proteins, plastocyanin/azurin family DUF5462 PF17547.2 AIC15678.1 - 0.022 14.1 0.1 0.23 10.8 0.0 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5462) CBM60 PF16841.5 AIC15678.1 - 0.12 12.9 6.0 0.43 11.0 0.3 2.4 2 0 0 2 2 2 0 Ca-dependent carbohydrate-binding module xylan-binding BetaGal_dom3 PF13363.6 AIC15678.1 - 0.3 10.7 3.0 0.54 9.9 0.2 2.6 2 1 1 3 3 3 0 Beta-galactosidase, domain 3 Peripla_BP_2 PF01497.18 AIC15679.1 - 1.7e-16 60.6 0.0 6.2e-16 58.7 0.0 1.9 1 1 0 1 1 1 1 Periplasmic binding protein Ribosomal_S10 PF00338.22 AIC15680.1 - 9.4e-25 86.7 0.0 1e-24 86.6 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S10p/S20e GTP_EFTU PF00009.27 AIC15681.1 - 8.5e-49 165.7 0.0 1.4e-48 165.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 AIC15681.1 - 1.8e-36 124.9 0.0 4.6e-36 123.5 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 AIC15681.1 - 1.2e-15 57.6 3.5 5.5e-15 55.5 1.7 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 AIC15681.1 - 1.3e-06 28.2 1.9 2.6e-06 27.2 1.1 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 AIC15681.1 - 0.0026 17.8 0.2 0.016 15.3 0.2 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 AIC15681.1 - 0.075 12.4 0.0 0.22 10.9 0.0 1.7 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region FBPase_3 PF01950.16 AIC15682.1 - 1.8e-150 501.1 0.0 2e-150 501.0 0.0 1.0 1 0 0 1 1 1 1 Fructose-1,6-bisphosphatase LBP_M PF17385.2 AIC15682.1 - 0.14 11.7 0.1 0.23 11.0 0.1 1.3 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase central domain TIM PF00121.18 AIC15683.1 - 3.8e-09 36.3 0.0 1.4e-08 34.5 0.0 1.7 1 1 1 2 2 2 1 Triosephosphate isomerase IGPS PF00218.21 AIC15683.1 - 0.0002 20.6 0.0 0.00053 19.2 0.0 1.7 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase ThiG PF05690.14 AIC15683.1 - 0.00037 19.9 0.3 0.00037 19.9 0.3 2.0 2 1 0 2 2 2 1 Thiazole biosynthesis protein ThiG FMN_dh PF01070.18 AIC15683.1 - 0.18 10.8 0.9 0.37 9.8 0.5 1.7 2 0 0 2 2 2 0 FMN-dependent dehydrogenase Methyltransf_31 PF13847.6 AIC15684.1 - 1.8e-18 66.8 0.0 2.7e-18 66.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15684.1 - 6e-13 49.3 0.6 1.3e-12 48.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC15684.1 - 6.3e-13 49.2 0.2 1.5e-12 48.0 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15684.1 - 9.5e-11 42.3 0.2 8.1e-10 39.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15684.1 - 3.7e-09 36.6 0.0 1.2e-08 35.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 AIC15684.1 - 2e-07 31.1 0.0 3.7e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 AIC15684.1 - 2.1e-07 30.9 0.0 3.1e-07 30.3 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_2 PF00891.18 AIC15684.1 - 4.4e-07 29.4 0.2 9e-05 21.9 0.0 2.2 2 0 0 2 2 2 2 O-methyltransferase domain MTS PF05175.14 AIC15684.1 - 8.4e-07 28.7 0.2 1e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Ubie_methyltran PF01209.18 AIC15684.1 - 4.5e-05 22.9 0.0 7.2e-05 22.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family CMAS PF02353.20 AIC15684.1 - 6.4e-05 22.4 0.0 0.00013 21.4 0.0 1.4 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase PrmA PF06325.13 AIC15684.1 - 0.00013 21.5 0.2 0.00024 20.6 0.0 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 AIC15684.1 - 0.00018 21.0 0.0 0.00029 20.4 0.0 1.3 1 0 0 1 1 1 1 Putative methyltransferase UPF0020 PF01170.18 AIC15684.1 - 0.0022 17.7 0.0 0.0038 16.9 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_24 PF13578.6 AIC15684.1 - 0.0064 17.5 0.0 0.02 15.9 0.0 1.8 2 0 0 2 2 1 1 Methyltransferase domain PCMT PF01135.19 AIC15684.1 - 0.012 15.4 0.0 0.02 14.6 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_15 PF09445.10 AIC15684.1 - 0.027 14.0 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase TehB PF03848.14 AIC15684.1 - 0.037 13.4 0.0 0.058 12.8 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_32 PF13679.6 AIC15684.1 - 0.058 13.4 0.3 0.094 12.7 0.0 1.5 2 0 0 2 2 1 0 Methyltransferase domain UPF0126 PF03458.13 AIC15685.1 - 2.4e-40 136.3 27.7 5.9e-22 77.4 7.8 2.4 2 1 0 2 2 2 2 UPF0126 domain B12D PF06522.11 AIC15685.1 - 0.037 13.8 0.2 0.037 13.8 0.2 2.5 2 0 0 2 2 2 0 NADH-ubiquinone reductase complex 1 MLRQ subunit PEP-utilizers_C PF02896.18 AIC15686.1 - 3e-85 285.9 2.3 4.3e-85 285.4 2.3 1.2 1 0 0 1 1 1 1 PEP-utilising enzyme, TIM barrel domain PPDK_N PF01326.19 AIC15686.1 - 1.3e-56 192.3 0.0 4.6e-44 151.0 0.0 3.3 1 1 1 2 2 2 2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain PEP-utilizers PF00391.23 AIC15686.1 - 1.1e-26 92.3 0.7 8.6e-26 89.5 0.4 2.5 2 0 0 2 2 2 1 PEP-utilising enzyme, mobile domain HpcH_HpaI PF03328.14 AIC15686.1 - 0.011 14.9 0.1 0.02 14.0 0.1 1.4 1 0 0 1 1 1 0 HpcH/HpaI aldolase/citrate lyase family HTH_50 PF18024.1 AIC15687.1 - 0.024 14.2 0.2 0.034 13.8 0.2 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain MFS_1 PF07690.16 AIC15688.1 - 1.4e-42 145.9 53.7 7.2e-42 143.6 50.6 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 AIC15688.1 - 1.6e-08 33.8 12.5 1.6e-08 33.8 12.5 2.7 2 1 0 2 2 2 1 Sugar (and other) transporter MFS_2 PF13347.6 AIC15688.1 - 0.0021 16.7 3.4 0.0021 16.7 3.4 4.5 3 2 0 4 4 4 1 MFS/sugar transport protein Glyoxalase PF00903.25 AIC15689.1 - 4.4e-06 26.9 0.0 1e-05 25.7 0.0 1.6 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIC15689.1 - 0.00057 20.7 0.0 0.001 19.9 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase-like domain Topoisom_I_N PF02919.15 AIC15689.1 - 0.011 15.2 0.3 0.38 10.2 0.3 2.0 1 1 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF1428 PF07237.11 AIC15690.1 - 3.8e-09 36.7 0.1 4.8e-09 36.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1428) HTH_45 PF14947.6 AIC15691.1 - 2.1e-12 46.8 0.1 3.1e-12 46.3 0.1 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DUF1611_N PF17396.2 AIC15691.1 - 0.013 15.7 0.0 0.021 15.1 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_N) Rossmann-like domain DUF2513 PF10711.9 AIC15691.1 - 0.099 12.9 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) Rio2_N PF09202.11 AIC15691.1 - 0.11 12.7 0.0 0.19 12.0 0.0 1.3 1 0 0 1 1 1 0 Rio2, N-terminal INCENP_N PF12178.8 AIC15691.1 - 0.18 11.8 0.0 5.2 7.2 0.0 2.3 2 1 0 2 2 2 0 Chromosome passenger complex (CPC) protein INCENP N terminal MEDS PF14417.6 AIC15692.1 - 2.6e-16 59.9 0.0 3.4e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain ATPase PF06745.13 AIC15692.1 - 0.00025 20.5 0.0 0.00031 20.2 0.0 1.2 1 0 0 1 1 1 1 KaiC DNA_RNApol_7kD PF03604.13 AIC15693.1 - 1.3e-05 24.7 2.6 2.5e-05 23.9 2.6 1.4 1 1 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit zf-Mss51 PF13824.6 AIC15693.1 - 0.019 15.0 0.1 0.033 14.3 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 DUF1451 PF07295.11 AIC15693.1 - 0.23 11.5 0.4 0.24 11.4 0.4 1.1 1 0 0 1 1 1 0 Zinc-ribbon containing domain zf-C2H2 PF00096.26 AIC15694.1 - 1.5e-07 31.4 6.0 0.00066 20.0 1.2 2.2 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC15694.1 - 6.9e-06 26.5 5.7 0.04 14.7 0.2 2.3 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AIC15694.1 - 0.00029 21.1 7.9 0.083 13.4 0.4 2.8 3 0 0 3 3 3 2 Zinc-finger double domain Zn-ribbon_8 PF09723.10 AIC15694.1 - 0.0011 19.0 4.9 0.33 11.1 0.6 2.2 2 0 0 2 2 2 2 Zinc ribbon domain zf_C2H2_ZHX PF18387.1 AIC15694.1 - 0.002 17.7 0.8 0.37 10.4 0.0 2.1 1 1 1 2 2 2 2 Zinc-fingers and homeoboxes C2H2 finger domain zf_UBZ PF18439.1 AIC15694.1 - 0.0021 17.6 4.6 0.24 11.0 1.0 2.3 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf-CW PF07496.15 AIC15694.1 - 0.012 15.6 1.1 0.019 15.0 1.1 1.3 1 0 0 1 1 1 0 CW-type Zinc Finger DUF3268 PF11672.8 AIC15694.1 - 0.013 15.8 0.6 0.015 15.6 0.6 1.2 1 0 0 1 1 1 0 zinc-finger-containing domain DZR PF12773.7 AIC15694.1 - 0.022 14.8 0.6 0.032 14.3 0.6 1.3 1 0 0 1 1 1 0 Double zinc ribbon Actin_micro PF17003.5 AIC15694.1 - 0.024 13.8 8.1 0.015 14.5 6.4 1.5 1 1 1 2 2 2 0 Putative actin-like family FOXP-CC PF16159.5 AIC15694.1 - 0.046 14.3 3.0 0.067 13.8 3.0 1.4 1 0 0 1 1 1 0 FOXP coiled-coil domain Evr1_Alr PF04777.13 AIC15694.1 - 0.061 13.8 4.0 1 9.8 4.0 2.0 1 1 0 1 1 1 0 Erv1 / Alr family zf-C2H2_2 PF12756.7 AIC15694.1 - 0.066 13.6 8.6 1.2 9.5 1.7 2.1 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-C2H2_jaz PF12171.8 AIC15694.1 - 0.07 13.4 9.6 0.61 10.4 0.6 2.4 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AIC15694.1 - 0.08 13.0 0.9 0.08 13.0 0.9 2.6 3 0 0 3 3 3 0 C2H2-type zinc finger HNH PF01844.23 AIC15694.1 - 0.081 13.1 3.1 6 7.1 0.4 2.2 2 0 0 2 2 2 0 HNH endonuclease zf-C2HC_2 PF13913.6 AIC15694.1 - 0.18 11.8 0.7 0.18 11.8 0.7 2.1 2 0 0 2 2 2 0 zinc-finger of a C2HC-type FYVE PF01363.21 AIC15694.1 - 0.22 11.7 4.9 0.43 10.7 4.0 1.8 1 1 1 2 2 2 0 FYVE zinc finger DUF629 PF04780.12 AIC15694.1 - 0.24 9.9 6.9 0.52 8.8 1.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF629) Lar_restr_allev PF14354.6 AIC15694.1 - 0.43 11.0 4.9 0.78 10.2 4.9 1.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar XPA_N PF01286.18 AIC15694.1 - 0.6 10.2 6.0 1.7 8.8 1.4 2.3 2 0 0 2 2 2 0 XPA protein N-terminal DUF983 PF06170.12 AIC15694.1 - 0.81 10.1 1.9 1.6 9.2 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF983) C1_1 PF00130.22 AIC15695.1 - 0.0016 18.3 12.2 0.27 11.1 0.6 3.4 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C4pol PF14260.6 AIC15695.1 - 0.0032 17.9 8.2 0.69 10.4 2.8 3.2 1 1 2 3 3 3 1 C4-type zinc-finger of DNA polymerase delta DZR PF12773.7 AIC15695.1 - 0.016 15.2 17.1 2 8.5 4.2 3.7 1 1 1 2 2 2 0 Double zinc ribbon DUF4428 PF14471.6 AIC15695.1 - 0.039 13.9 13.0 0.25 11.3 0.6 4.1 3 2 0 3 3 3 0 Domain of unknown function (DUF4428) Chordopox_RPO7 PF05864.12 AIC15695.1 - 0.061 13.6 0.0 16 5.9 0.0 2.8 2 0 0 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) LIM PF00412.22 AIC15695.1 - 0.064 13.5 11.3 2.7 8.3 1.3 3.9 3 2 0 3 3 3 0 LIM domain Zn_ribbon_recom PF13408.6 AIC15695.1 - 0.19 12.3 0.3 0.19 12.3 0.3 2.7 3 0 0 3 3 3 0 Recombinase zinc beta ribbon domain RecO_C PF02565.15 AIC15695.1 - 0.43 10.4 5.8 5.9 6.7 0.2 2.9 2 1 1 3 3 3 0 Recombination protein O C terminal Cytochrom_c3_2 PF14537.6 AIC15695.1 - 0.55 10.7 9.1 2.5 8.6 7.0 2.7 2 1 0 2 2 2 0 Cytochrome c3 zf-UDP PF14569.6 AIC15695.1 - 5 7.3 9.5 5.6 7.2 0.9 3.6 3 2 0 3 3 3 0 Zinc-binding RING-finger Yippee-Mis18 PF03226.14 AIC15695.1 - 9 6.6 10.8 1.6e+02 2.6 5.2 3.4 1 1 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-RING_10 PF16685.5 AIC15695.1 - 9.2 6.5 17.3 0.31 11.2 2.7 3.9 2 1 2 4 4 4 0 zinc RING finger of MSL2 P-II PF00543.22 AIC15696.1 - 6.2e-17 62.1 0.2 7.1e-17 61.9 0.2 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II P-II PF00543.22 AIC15698.1 - 1.6e-19 70.4 0.1 1.8e-19 70.2 0.1 1.0 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II adh_short_C2 PF13561.6 AIC15700.1 - 7.7e-68 228.5 0.9 8.9e-68 228.3 0.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 AIC15700.1 - 2.3e-57 193.6 1.6 2.8e-57 193.4 1.6 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 AIC15700.1 - 6e-11 42.6 0.3 8.7e-11 42.0 0.3 1.2 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 AIC15700.1 - 4.5e-08 32.8 0.2 1.4e-07 31.3 0.2 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AIC15700.1 - 6.9e-07 29.3 0.1 1.1e-06 28.7 0.1 1.5 1 0 0 1 1 1 1 NAD(P)H-binding Polysacc_synt_2 PF02719.15 AIC15700.1 - 3.5e-06 26.4 0.7 4.9e-06 25.9 0.7 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 AIC15700.1 - 6.2e-06 26.5 0.4 1.1e-05 25.7 0.4 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 AIC15700.1 - 0.00011 22.3 0.5 0.00026 21.0 0.5 1.6 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase F420_oxidored PF03807.17 AIC15700.1 - 0.00013 22.5 1.3 0.00027 21.5 1.3 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent GDP_Man_Dehyd PF16363.5 AIC15700.1 - 0.00017 21.1 0.3 0.0016 17.9 0.3 2.1 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase TrkA_N PF02254.18 AIC15700.1 - 0.0012 19.1 0.4 0.0023 18.2 0.4 1.4 1 0 0 1 1 1 1 TrkA-N domain 3Beta_HSD PF01073.19 AIC15700.1 - 0.0014 17.7 0.1 0.0019 17.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family 3HCDH_N PF02737.18 AIC15700.1 - 0.0023 17.8 1.0 0.0035 17.3 1.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 AIC15700.1 - 0.0048 16.6 0.1 0.0075 15.9 0.1 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA NAD_binding_4 PF07993.12 AIC15700.1 - 0.01 15.0 0.8 0.025 13.8 0.8 1.6 1 1 0 1 1 1 0 Male sterility protein NmrA PF05368.13 AIC15700.1 - 0.012 15.1 1.2 0.1 12.1 0.9 2.0 2 0 0 2 2 2 0 NmrA-like family DUF3842 PF12953.7 AIC15700.1 - 0.021 15.2 2.0 0.041 14.3 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3842) RmlD_sub_bind PF04321.17 AIC15700.1 - 0.021 13.9 0.3 0.067 12.3 0.1 1.8 2 0 0 2 2 2 0 RmlD substrate binding domain NAD_binding_2 PF03446.15 AIC15700.1 - 0.046 13.9 0.1 0.11 12.7 0.1 1.5 1 1 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_7 PF13241.6 AIC15700.1 - 0.077 13.4 0.3 0.15 12.5 0.3 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 AIC15700.1 - 0.082 12.3 0.2 0.14 11.5 0.2 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain DHHA1 PF02272.19 AIC15701.1 - 0.00021 21.7 0.0 0.00041 20.8 0.0 1.5 1 0 0 1 1 1 1 DHHA1 domain DHH PF01368.20 AIC15701.1 - 0.0068 16.6 0.0 0.013 15.7 0.0 1.5 1 0 0 1 1 1 1 DHH family HAD_2 PF13419.6 AIC15702.1 - 8.1e-25 87.9 0.0 9.7e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIC15702.1 - 1.9e-14 54.5 0.2 3.4e-13 50.4 0.2 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AIC15702.1 - 7.4e-05 23.2 0.0 0.00012 22.5 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIC15702.1 - 0.00085 19.3 0.0 0.0042 17.1 0.0 2.0 2 0 0 2 2 2 1 HAD-hyrolase-like Hydrolase_6 PF13344.6 AIC15702.1 - 0.067 13.3 0.1 2.8 8.1 0.0 2.9 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase tRNA-synt_1f PF01921.18 AIC15704.1 - 5.6e-106 354.5 0.0 7.5e-106 354.1 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (K) Trigger_C PF05698.14 AIC15704.1 - 0.016 15.2 0.1 0.037 14.0 0.1 1.5 1 0 0 1 1 1 0 Bacterial trigger factor protein (TF) C-terminus tRNA-synt_1 PF00133.22 AIC15704.1 - 0.12 10.6 0.0 0.2 9.9 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) Radical_SAM_C PF16199.5 AIC15705.1 - 1.6e-25 88.9 0.1 3.3e-25 87.9 0.1 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 AIC15705.1 - 1e-21 78.0 0.0 2.4e-21 76.9 0.0 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 AIC15705.1 - 1.6e-11 44.5 0.1 3.8e-11 43.2 0.1 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 AIC15705.1 - 9.2e-06 25.6 0.3 4.9e-05 23.3 0.1 2.3 3 1 0 3 3 3 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AIC15705.1 - 0.043 14.3 0.1 0.1 13.1 0.1 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain AIRS_C PF02769.22 AIC15706.1 - 2e-20 73.5 0.0 3.9e-20 72.6 0.0 1.5 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 AIC15706.1 - 2.3e-16 60.2 1.3 4.8e-16 59.2 1.3 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain CitMHS PF03600.16 AIC15707.1 - 0.064 12.4 0.1 0.064 12.4 0.1 1.0 1 0 0 1 1 1 0 Citrate transporter zf-C2H2_jaz PF12171.8 AIC15708.1 - 0.018 15.3 0.3 0.031 14.6 0.3 1.4 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-CGNR PF11706.8 AIC15708.1 - 0.026 14.4 2.7 0.052 13.4 2.7 1.5 1 0 0 1 1 1 0 CGNR zinc finger UreD PF01774.17 AIC15709.1 - 9.6e-45 153.1 0.0 1.2e-44 152.8 0.0 1.1 1 0 0 1 1 1 1 UreD urease accessory protein cobW PF02492.19 AIC15710.1 - 1.2e-31 109.6 0.0 1.5e-31 109.4 0.0 1.1 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 AIC15710.1 - 5.6e-09 35.4 1.0 1.5e-08 34.0 1.0 1.6 1 1 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 AIC15710.1 - 8.7e-05 22.4 0.1 0.00021 21.2 0.1 1.7 1 1 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B NTPase_1 PF03266.15 AIC15710.1 - 0.0036 17.2 0.0 0.0071 16.3 0.0 1.5 1 0 0 1 1 1 1 NTPase ABC_tran PF00005.27 AIC15710.1 - 0.015 15.8 0.0 0.021 15.4 0.0 1.2 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 AIC15710.1 - 0.022 14.2 0.0 0.03 13.7 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI GTP_EFTU PF00009.27 AIC15710.1 - 0.081 12.5 0.1 10 5.6 0.0 2.8 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 AIC15710.1 - 0.11 12.8 0.0 1.2 9.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain LpxK PF02606.14 AIC15710.1 - 0.15 11.1 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase PRK PF00485.18 AIC15710.1 - 0.18 11.5 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family UreF PF01730.16 AIC15711.1 - 5.5e-24 85.2 0.0 6.9e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 UreF CdhC PF03598.15 AIC15711.1 - 0.12 12.2 0.1 0.21 11.4 0.1 1.3 1 0 0 1 1 1 0 CO dehydrogenase/acetyl-CoA synthase complex beta subunit UreE_N PF02814.15 AIC15712.1 - 5.4e-11 41.9 0.1 8.2e-11 41.3 0.1 1.2 1 0 0 1 1 1 1 UreE urease accessory protein, N-terminal domain UreE_C PF05194.12 AIC15712.1 - 0.00014 22.3 0.1 0.0003 21.2 0.1 1.6 2 0 0 2 2 2 1 UreE urease accessory protein, C-terminal domain Cpn60_TCP1 PF00118.24 AIC15714.1 - 8.9e-105 351.1 11.2 1.1e-104 350.8 11.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Amidohydro_1 PF01979.20 AIC15715.1 - 3.4e-62 210.7 0.8 4.4e-62 210.4 0.8 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 AIC15715.1 - 2.6e-51 173.0 1.1 6.9e-51 171.7 1.1 1.8 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.11 AIC15715.1 - 7.8e-06 25.6 1.5 7.8e-06 25.6 1.5 2.2 1 1 1 2 2 2 1 Amidohydrolase family Urease_beta PF00699.20 AIC15716.1 - 5.7e-41 138.5 0.0 7.5e-41 138.1 0.0 1.1 1 0 0 1 1 1 1 Urease beta subunit Urease_gamma PF00547.18 AIC15717.1 - 1.7e-43 146.9 0.1 1.9e-43 146.8 0.1 1.0 1 0 0 1 1 1 1 Urease, gamma subunit TrbI_Ftype PF09677.10 AIC15717.1 - 0.0024 18.1 0.2 0.038 14.3 0.1 2.0 1 1 1 2 2 2 2 Type-F conjugative transfer system protein (TrbI_Ftype) Svf1_C PF17187.4 AIC15717.1 - 0.048 13.5 0.1 0.054 13.3 0.1 1.1 1 0 0 1 1 1 0 Svf1-like C-terminal lipocalin-like domain DUF929 PF06053.11 AIC15717.1 - 0.12 11.7 0.0 0.14 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF929) UT PF03253.14 AIC15719.1 - 1.1e-50 172.4 40.3 1.2e-20 73.8 11.4 3.0 2 1 1 3 3 3 3 Urea transporter SSF PF00474.17 AIC15720.1 - 1.4e-23 83.4 38.3 2.8e-23 82.5 38.3 1.5 1 0 0 1 1 1 1 Sodium:solute symporter family Usp PF00582.26 AIC15720.1 - 9e-23 81.3 0.0 1.7e-22 80.4 0.0 1.4 1 0 0 1 1 1 1 Universal stress protein family ParBc PF02195.18 AIC15722.1 - 7.5e-21 74.2 0.3 1.2e-19 70.4 0.0 2.3 2 0 0 2 2 2 1 ParB-like nuclease domain HTH_ParB PF17762.1 AIC15722.1 - 1.5e-06 27.9 2.0 3.9e-06 26.6 2.0 1.7 1 0 0 1 1 1 1 HTH domain found in ParB protein KorB PF08535.10 AIC15722.1 - 7.4e-06 25.9 0.2 2.5e-05 24.2 0.1 2.0 2 0 0 2 2 2 1 KorB domain HTH_5 PF01022.20 AIC15722.1 - 0.022 14.6 0.2 0.91 9.4 0.1 3.0 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family GIDA PF01134.22 AIC15722.1 - 0.055 12.5 0.3 0.13 11.3 0.1 1.6 2 0 0 2 2 2 0 Glucose inhibited division protein A DUF745 PF05335.13 AIC15722.1 - 0.14 11.9 1.5 0.21 11.3 1.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Usp PF00582.26 AIC15725.1 - 9.1e-33 113.7 1.1 1.6e-32 113.0 1.1 1.4 1 1 0 1 1 1 1 Universal stress protein family ApoC-I PF04691.12 AIC15728.1 - 0.18 11.8 3.4 2.1 8.3 0.1 2.5 2 0 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) SSF PF00474.17 AIC15729.1 - 9.4e-30 103.8 28.9 9.4e-30 103.8 28.9 1.4 2 0 0 2 2 2 1 Sodium:solute symporter family ParBc PF02195.18 AIC15731.1 - 2.2e-10 40.7 0.0 4.8e-10 39.6 0.0 1.6 1 0 0 1 1 1 1 ParB-like nuclease domain HTH_23 PF13384.6 AIC15731.1 - 0.0046 16.7 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 Homeodomain-like domain CENP-B_N PF04218.13 AIC15731.1 - 0.037 13.7 0.0 0.093 12.4 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_28 PF13518.6 AIC15731.1 - 0.041 14.0 0.0 0.099 12.8 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Arginase PF00491.21 AIC15733.1 - 1.1e-76 258.0 0.0 1.3e-76 257.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family Urease_gamma PF00547.18 AIC15734.1 - 2.7e-11 43.7 0.1 3.4e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 Urease, gamma subunit ABC-3 PF00950.17 AIC15735.1 - 5.8e-66 222.6 31.2 6.7e-66 222.4 31.2 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 AIC15735.1 - 5.5e-09 35.5 31.7 1.3e-08 34.2 31.7 1.7 1 1 0 1 1 1 1 FecCD transport family DUF3989 PF13150.6 AIC15735.1 - 0.34 10.7 2.6 18 5.2 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3989) ABC_tran PF00005.27 AIC15736.1 - 1.5e-28 100.0 0.0 2.2e-28 99.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC15736.1 - 6.3e-15 55.8 0.4 4.6e-09 36.5 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 AIC15736.1 - 0.00025 20.8 0.5 0.068 12.9 0.1 2.1 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 AIC15736.1 - 0.0019 18.7 0.1 0.015 15.7 0.1 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 AIC15736.1 - 0.0019 17.7 0.2 1.7 8.0 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 AIC15736.1 - 0.003 17.7 0.1 0.066 13.5 0.1 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_29 PF13555.6 AIC15736.1 - 0.0037 17.0 0.1 0.0074 16.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NACHT PF05729.12 AIC15736.1 - 0.012 15.5 0.2 0.027 14.4 0.1 1.5 2 0 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 AIC15736.1 - 0.02 15.2 0.1 0.26 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AIC15736.1 - 0.02 15.3 0.1 0.077 13.4 0.1 1.8 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 AIC15736.1 - 0.032 13.4 0.3 0.23 10.6 0.2 1.9 2 0 0 2 2 2 0 NB-ARC domain AAA_24 PF13479.6 AIC15736.1 - 0.035 13.8 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 AIC15736.1 - 0.039 14.4 0.4 0.06 13.9 0.4 1.2 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 AIC15736.1 - 0.052 13.4 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 AIC15736.1 - 0.07 13.7 0.1 0.15 12.6 0.0 1.6 2 0 0 2 2 1 0 AAA domain DUF3987 PF13148.6 AIC15736.1 - 0.085 11.9 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Mg_chelatase PF01078.21 AIC15736.1 - 0.097 12.0 0.1 0.23 10.8 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI NTPase_1 PF03266.15 AIC15736.1 - 0.11 12.4 0.1 0.61 10.0 0.1 2.0 2 0 0 2 2 2 0 NTPase ATPase_2 PF01637.18 AIC15736.1 - 0.12 12.2 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 AIC15736.1 - 0.12 12.5 0.2 0.34 11.1 0.2 1.8 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AIC15736.1 - 0.13 11.8 0.3 0.57 9.7 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 AIC15736.1 - 0.15 12.1 0.2 1.3 9.1 0.1 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) cobW PF02492.19 AIC15736.1 - 0.16 11.5 0.3 0.33 10.5 0.3 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain IstB_IS21 PF01695.17 AIC15736.1 - 0.16 11.7 0.3 20 4.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein DUF87 PF01935.17 AIC15736.1 - 0.26 11.4 0.2 0.44 10.6 0.2 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain ZnuA PF01297.17 AIC15737.1 - 2.4e-73 246.7 0.0 3.1e-73 246.3 0.0 1.1 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic NikR_C PF08753.11 AIC15741.1 - 1.1e-25 89.6 4.0 1.1e-25 89.6 4.0 1.5 2 0 0 2 2 2 1 NikR C terminal nickel binding domain RHH_1 PF01402.21 AIC15741.1 - 0.027 14.4 0.3 0.39 10.7 0.0 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family Cpn60_TCP1 PF00118.24 AIC15743.1 - 4.7e-144 480.7 9.8 5.3e-144 480.5 9.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Urease_gamma PF00547.18 AIC15744.1 - 1.3e-46 156.9 0.0 1.4e-46 156.8 0.0 1.0 1 0 0 1 1 1 1 Urease, gamma subunit Urease_beta PF00699.20 AIC15745.1 - 1.1e-40 137.6 0.0 1.3e-40 137.3 0.0 1.1 1 0 0 1 1 1 1 Urease beta subunit Amidohydro_1 PF01979.20 AIC15746.1 - 3.5e-79 266.6 0.5 4.9e-79 266.1 0.5 1.1 1 0 0 1 1 1 1 Amidohydrolase family Urease_alpha PF00449.20 AIC15746.1 - 1.5e-50 170.5 2.9 3.2e-50 169.5 2.9 1.6 1 0 0 1 1 1 1 Urease alpha-subunit, N-terminal domain Amidohydro_3 PF07969.11 AIC15746.1 - 3.4e-06 26.8 3.1 9.4e-05 22.1 0.4 2.6 1 1 1 2 2 2 2 Amidohydrolase family Citrate_synt PF00285.21 AIC15748.1 - 7.2e-124 413.5 0.0 8.3e-124 413.3 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Bac_luciferase PF00296.20 AIC15750.1 - 5.3e-59 200.2 0.0 6.6e-59 199.9 0.0 1.0 1 0 0 1 1 1 1 Luciferase-like monooxygenase Lactamase_B_2 PF12706.7 AIC15751.1 - 0.0014 18.2 0.2 0.076 12.5 0.3 2.9 2 1 0 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIC15751.1 - 0.0077 16.1 0.1 0.022 14.7 0.0 1.7 2 0 0 2 2 2 1 Beta-lactamase superfamily domain RMMBL PF07521.12 AIC15751.1 - 0.013 15.4 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 AIC15751.1 - 0.3 11.1 1.8 5.8 6.9 0.7 2.4 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily Formyl_trans_N PF00551.19 AIC15752.1 - 2.1e-51 174.2 0.0 2.4e-51 174.0 0.0 1.0 1 0 0 1 1 1 1 Formyl transferase MFS_1 PF07690.16 AIC15753.1 - 2.3e-33 115.6 48.0 9.7e-22 77.4 19.3 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_4 PF06779.14 AIC15753.1 - 2e-16 60.3 31.8 2.4e-16 60.0 31.8 1.0 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB MFS_1_like PF12832.7 AIC15753.1 - 0.00014 20.9 25.5 0.005 15.7 7.2 2.7 2 1 0 2 2 2 2 MFS_1 like family UNC-93 PF05978.16 AIC15753.1 - 0.0018 18.0 3.0 0.0018 18.0 3.0 2.4 2 0 0 2 2 2 1 Ion channel regulatory protein UNC-93 MASE2 PF05230.11 AIC15753.1 - 0.048 13.7 7.8 0.068 13.3 0.7 3.3 2 0 0 2 2 2 0 MASE2 domain OATP PF03137.20 AIC15753.1 - 0.63 8.3 6.1 0.15 10.3 0.5 2.5 2 1 1 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family Ubie_methyltran PF01209.18 AIC15754.1 - 4.7e-23 81.7 0.0 5.3e-23 81.6 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_11 PF08241.12 AIC15754.1 - 1.3e-17 64.2 0.0 2.2e-17 63.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15754.1 - 3.8e-17 62.8 0.0 7.5e-17 61.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC15754.1 - 1.7e-11 44.1 0.0 2.5e-11 43.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15754.1 - 4.7e-09 36.9 0.0 7.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15754.1 - 2.5e-08 33.9 0.0 2.9e-08 33.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIC15754.1 - 0.0043 16.6 0.0 0.0072 15.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 AIC15754.1 - 0.0045 16.9 0.0 0.0067 16.3 0.0 1.3 1 0 0 1 1 1 1 Hypothetical methyltransferase DEAD PF00270.29 AIC15755.1 - 4.8e-33 114.4 0.0 9.3e-33 113.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIC15755.1 - 1.6e-13 50.9 0.0 1.6e-09 38.1 0.0 2.6 2 0 0 2 2 2 2 Helicase conserved C-terminal domain DUF1998 PF09369.10 AIC15755.1 - 2e-10 41.3 0.1 6.6e-10 39.6 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) zinc_ribbon_4 PF13717.6 AIC15755.1 - 0.0078 16.1 1.2 0.0078 16.1 1.2 2.3 2 0 0 2 2 2 1 zinc-ribbon domain Topoisom_I_N PF02919.15 AIC15756.1 - 5e-65 219.0 1.0 5e-65 219.0 1.0 2.0 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topoisom_I PF01028.20 AIC15756.1 - 5.4e-63 212.3 4.7 5.4e-63 212.3 4.7 1.8 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topo_C_assoc PF14370.6 AIC15756.1 - 2.9e-21 75.1 4.0 3e-21 75.1 1.4 2.5 2 0 0 2 2 2 1 C-terminal topoisomerase domain Sipho_tail PF05709.11 AIC15756.1 - 0.053 12.9 0.1 0.099 12.1 0.1 1.4 1 0 0 1 1 1 0 Phage tail protein DUF4226 PF10774.9 AIC15756.1 - 1.5 9.1 9.2 0.08 13.2 3.0 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4226) AP2 PF00847.20 AIC15756.1 - 1.7 8.9 7.4 13 6.1 0.0 3.7 4 0 0 4 4 4 0 AP2 domain AAA_23 PF13476.6 AIC15756.1 - 2.5 8.6 16.8 0.92 10.0 6.4 2.6 2 1 0 2 2 2 0 AAA domain MarR_2 PF12802.7 AIC15757.1 - 1.2e-05 25.1 0.5 0.00013 21.8 0.1 2.5 2 0 0 2 2 2 1 MarR family TPR_12 PF13424.6 AIC15757.1 - 0.0014 18.9 3.6 0.31 11.3 1.5 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat HTH_IclR PF09339.10 AIC15757.1 - 0.002 17.9 0.0 0.0063 16.3 0.0 1.9 1 0 0 1 1 1 1 IclR helix-turn-helix domain TrmB PF01978.19 AIC15757.1 - 0.013 15.4 0.0 0.03 14.2 0.0 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIC15757.1 - 0.014 15.0 0.0 0.031 13.9 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 AIC15757.1 - 0.095 12.8 0.1 0.25 11.4 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain TPR_16 PF13432.6 AIC15757.1 - 0.27 11.9 6.6 2.9 8.6 1.2 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat CBS PF00571.28 AIC15758.1 - 1.2e-17 64.1 2.5 9.5e-08 32.4 0.3 2.3 2 0 0 2 2 2 2 CBS domain zf-C2H2_4 PF13894.6 AIC15758.1 - 0.00056 20.5 0.1 0.0014 19.3 0.1 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC15758.1 - 0.00065 20.0 0.1 0.0013 19.1 0.1 1.5 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-Di19 PF05605.12 AIC15758.1 - 0.0095 16.2 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_9 PF16293.5 AIC15758.1 - 0.015 15.2 0.1 0.035 13.9 0.0 1.7 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) zf_C2H2_6 PF18450.1 AIC15758.1 - 0.037 13.7 0.1 0.063 13.0 0.1 1.4 1 0 0 1 1 1 0 Zinc Finger domain LpxD PF04613.14 AIC15758.1 - 0.15 11.9 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD zf-C2H2_2 PF12756.7 AIC15758.1 - 0.18 12.2 0.0 0.36 11.2 0.0 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2 PF00096.26 AIC15759.1 - 4.6e-05 23.6 1.0 6.4e-05 23.2 1.0 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC15759.1 - 0.00045 20.8 1.0 0.00063 20.4 1.0 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-CCHC_2 PF13696.6 AIC15759.1 - 0.037 13.9 0.7 0.054 13.3 0.7 1.2 1 0 0 1 1 1 0 Zinc knuckle zf-H2C2_2 PF13465.6 AIC15759.1 - 0.048 14.1 4.1 1.3 9.6 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger double domain Desulfoferrod_N PF06397.12 AIC15759.1 - 0.066 12.8 0.5 0.18 11.5 0.4 1.7 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain zf-met PF12874.7 AIC15759.1 - 0.1 13.0 0.7 0.13 12.6 0.7 1.2 1 0 0 1 1 1 0 Zinc-finger of C2H2 type eIF2A PF08662.11 AIC15760.1 - 0.0026 17.6 0.0 0.0046 16.8 0.0 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 AIC15760.1 - 0.0029 17.5 0.6 3.2 7.8 0.0 3.9 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 AIC15760.1 - 0.17 12.2 0.0 0.67 10.3 0.0 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Lyase_1 PF00206.20 AIC15762.1 - 2.4e-43 148.7 0.9 3.8e-43 148.1 0.1 1.7 2 0 0 2 2 2 1 Lyase ADSL_C PF10397.9 AIC15762.1 - 8e-14 51.9 0.2 2.2e-13 50.5 0.2 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminus ASL_C PF08328.11 AIC15762.1 - 0.00056 20.0 0.1 0.0016 18.5 0.1 1.8 1 0 0 1 1 1 1 Adenylosuccinate lyase C-terminal RtcB PF01139.17 AIC15763.1 - 1.7e-162 541.3 0.0 2e-162 541.1 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Complex1_LYR PF05347.15 AIC15763.1 - 0.17 11.9 0.2 0.34 11.0 0.2 1.4 1 0 0 1 1 1 0 Complex 1 protein (LYR family) dsDNA_bind PF01984.20 AIC15764.1 - 3.2e-07 30.6 0.4 3.8e-07 30.4 0.4 1.1 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Ribosomal_S11 PF00411.19 AIC15766.1 - 5.7e-44 149.0 1.4 6.6e-44 148.8 1.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S11 Methyltransf_11 PF08241.12 AIC15767.1 - 3.2e-14 53.3 0.0 2.4e-13 50.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15767.1 - 4.4e-10 40.1 0.0 1.2e-09 38.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC15767.1 - 2.1e-06 27.6 0.0 3.2e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15767.1 - 0.00034 21.3 0.0 0.00058 20.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15767.1 - 0.00043 20.2 0.0 0.0005 19.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain SPC25 PF06703.11 AIC15768.1 - 1.5 8.6 6.4 0.35 10.6 0.5 2.3 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4332 PF14229.6 AIC15770.1 - 0.081 13.2 0.0 0.084 13.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4332) HATPase_c PF02518.26 AIC15771.1 - 3.7e-22 78.9 0.1 1e-21 77.5 0.1 1.8 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIC15771.1 - 6.9e-14 51.6 0.2 1.6e-13 50.5 0.2 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain PAS_9 PF13426.7 AIC15771.1 - 1.5e-08 34.8 0.0 3.6e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 PAS domain PAS PF00989.25 AIC15771.1 - 3.5e-05 23.8 0.0 0.00016 21.6 0.0 2.1 1 1 1 2 2 2 1 PAS fold PAS_4 PF08448.10 AIC15771.1 - 0.033 14.4 0.0 0.32 11.3 0.0 2.2 2 0 0 2 2 2 0 PAS fold HATPase_c_3 PF13589.6 AIC15771.1 - 0.056 13.3 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Response_reg PF00072.24 AIC15772.1 - 3.8e-15 56.0 0.1 6.1e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 Response regulator receiver domain FlaC_arch PF05377.11 AIC15772.1 - 0.17 12.3 1.2 1.6 9.2 0.4 2.3 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) ssDNA_TraI_N PF18272.1 AIC15773.1 - 0.05 13.6 0.1 0.31 11.1 0.1 2.3 2 0 0 2 2 2 0 single-stranded DNA binding TraI N-terminal subdomain SfLAP PF11139.8 AIC15774.1 - 0.018 14.5 6.2 0.025 14.0 6.2 1.2 1 0 0 1 1 1 0 Sap, sulfolipid-1-addressing protein zf-BED PF02892.15 AIC15775.1 - 1.4 9.0 3.6 23 5.1 3.6 2.2 1 1 0 1 1 1 0 BED zinc finger AIRS PF00586.24 AIC15776.1 - 5e-18 65.6 0.2 1.2e-17 64.4 0.2 1.6 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain AIRS_C PF02769.22 AIC15776.1 - 5.1e-09 36.5 0.1 9.4e-09 35.6 0.1 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain PGM_PMM_I PF02878.16 AIC15777.1 - 4.7e-24 84.7 0.0 1e-23 83.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 AIC15777.1 - 6.9e-17 61.7 0.2 1.5e-16 60.6 0.2 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 AIC15777.1 - 3.7e-14 53.2 0.1 7.5e-14 52.2 0.1 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_IV PF00408.20 AIC15777.1 - 5.3e-07 29.7 0.0 1.9e-06 28.0 0.0 1.9 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain P-II PF00543.22 AIC15778.1 - 1.2e-07 32.2 0.1 1.6e-07 31.9 0.1 1.2 1 0 0 1 1 1 1 Nitrogen regulatory protein P-II Cpn60_TCP1 PF00118.24 AIC15779.1 - 1e-178 595.0 16.6 1.2e-178 594.8 16.6 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family zf-C2H2_6 PF13912.6 AIC15782.1 - 0.04 13.9 0.4 0.074 13.1 0.4 1.4 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC15782.1 - 0.071 13.6 0.3 0.17 12.4 0.1 1.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_12 PF18658.1 AIC15782.1 - 0.1 12.2 0.1 0.33 10.5 0.0 1.8 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-C2H2_4 PF13894.6 AIC15782.1 - 0.19 12.7 0.8 0.75 10.8 0.2 2.2 2 0 0 2 2 2 0 C2H2-type zinc finger Polysacc_deac_1 PF01522.21 AIC15784.1 - 1e-09 38.4 0.0 1.7e-09 37.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2127 PF09900.9 AIC15785.1 - 0.0029 17.9 18.5 0.11 12.8 18.5 2.1 1 1 0 1 1 1 1 Predicted membrane protein (DUF2127) Ytp1 PF10355.9 AIC15785.1 - 0.011 15.0 2.7 0.011 15.0 2.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (Ytp1) PGA2 PF07543.12 AIC15785.1 - 0.41 10.6 0.3 0.63 10.0 0.3 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 Ubiq-assoc PF09145.10 AIC15786.1 - 0.068 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin-associated FemAB_like PF04339.12 AIC15788.1 - 0.015 14.4 1.3 0.016 14.3 1.3 1.0 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition DNA_pol_D_N PF18018.1 AIC15788.1 - 0.041 14.0 0.2 0.041 14.0 0.2 1.1 1 0 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain DUF2208 PF09973.9 AIC15789.1 - 0.091 12.4 0.5 0.097 12.3 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) zn-ribbon_14 PF16503.5 AIC15790.1 - 0.014 14.9 0.2 0.022 14.3 0.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon DUF4451 PF14616.6 AIC15791.1 - 0.13 12.5 0.2 0.24 11.6 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) DUF2071 PF09844.9 AIC15792.1 - 0.0016 18.1 0.0 0.002 17.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (COG2071) N6_N4_Mtase PF01555.18 AIC15793.1 - 1.4e-48 165.6 0.0 8.9e-48 163.0 0.0 1.8 1 1 0 1 1 1 1 DNA methylase UPF0020 PF01170.18 AIC15793.1 - 0.00065 19.4 0.0 0.04 13.6 0.0 2.4 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 MTS PF05175.14 AIC15793.1 - 0.0032 17.0 0.0 0.38 10.3 0.0 2.9 2 1 0 2 2 2 1 Methyltransferase small domain Methyltransf_31 PF13847.6 AIC15793.1 - 0.011 15.6 0.0 0.026 14.3 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15793.1 - 0.024 15.3 0.0 0.34 11.7 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase domain Nitroreductase PF00881.24 AIC15794.1 - 2.5e-24 86.2 0.1 5.6e-24 85.1 0.1 1.5 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 AIC15794.1 - 0.0033 17.0 0.2 0.73 9.4 0.1 2.8 2 1 1 3 3 3 2 Putative TM nitroreductase Methyltransf_4 PF02390.17 AIC15795.1 - 4.3e-08 32.8 0.0 9.8e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 Putative methyltransferase HD PF01966.22 AIC15795.1 - 2.5e-05 24.5 0.0 6.3e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 HD domain PDEase_I PF00233.19 AIC15795.1 - 0.0038 17.0 0.0 0.0085 15.8 0.0 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HxlR PF01638.17 AIC15796.1 - 2.4e-19 69.0 0.1 3.1e-19 68.6 0.1 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_24 PF13412.6 AIC15796.1 - 0.013 15.0 0.0 0.023 14.3 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIC15796.1 - 0.014 15.2 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 MarR family MarR PF01047.22 AIC15796.1 - 0.021 14.8 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 MarR family Arc_PepC_II PF06847.11 AIC15796.1 - 0.056 14.0 0.1 0.081 13.5 0.1 1.3 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminus Type II Fe_dep_repress PF01325.19 AIC15796.1 - 0.084 13.1 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain HTH_20 PF12840.7 AIC15796.1 - 0.096 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_12 PF08461.10 AIC15796.1 - 0.098 12.6 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain HTH_5 PF01022.20 AIC15796.1 - 0.11 12.4 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.6 AIC15796.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Glyoxalase_6 PF18029.1 AIC15797.1 - 3.5e-05 24.6 0.0 4.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Glyoxalase-like domain HEAT_2 PF13646.6 AIC15799.1 - 7e-23 80.8 1.5 7e-17 61.6 0.2 2.1 1 1 1 2 2 2 2 HEAT repeats HEAT_PBS PF03130.16 AIC15799.1 - 1.6e-11 43.8 0.3 0.093 13.5 0.0 4.1 4 0 0 4 4 4 3 PBS lyase HEAT-like repeat HEAT PF02985.22 AIC15799.1 - 1.7e-11 43.4 0.3 0.08 13.2 0.1 4.2 4 0 0 4 4 4 3 HEAT repeat HEAT_EZ PF13513.6 AIC15799.1 - 5e-07 30.1 1.0 0.28 11.8 0.3 4.0 3 1 1 4 4 4 2 HEAT-like repeat Cnd1 PF12717.7 AIC15799.1 - 9e-06 25.8 0.2 1.5 8.8 0.1 3.4 1 1 3 4 4 4 4 non-SMC mitotic condensation complex subunit 1 Arm PF00514.23 AIC15799.1 - 0.0023 17.9 0.0 24 5.2 0.1 3.9 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Adaptin_N PF01602.20 AIC15799.1 - 0.012 14.2 0.4 0.28 9.7 0.0 2.1 1 1 1 2 2 2 0 Adaptin N terminal region DUF4042 PF13251.6 AIC15799.1 - 0.036 13.8 0.1 4.7 6.9 0.0 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4042) DUF3385 PF11865.8 AIC15799.1 - 0.16 11.8 0.0 4.4 7.2 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3385) TPR_16 PF13432.6 AIC15799.1 - 0.18 12.4 0.9 21 5.9 0.5 2.7 1 1 2 3 3 3 0 Tetratricopeptide repeat TatC PF00902.18 AIC15801.1 - 3.7e-48 164.1 20.0 4.4e-48 163.9 20.0 1.0 1 0 0 1 1 1 1 Sec-independent protein translocase protein (TatC) MttA_Hcf106 PF02416.16 AIC15802.1 - 2.5e-09 36.3 0.1 2e-08 33.4 0.1 2.0 2 0 0 2 2 2 1 mttA/Hcf106 family DUF4834 PF16118.5 AIC15802.1 - 0.0048 17.8 0.1 0.006 17.5 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 AIC15802.1 - 0.019 15.6 0.0 0.026 15.1 0.0 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Cpta_toxin PF07254.12 AIC15802.1 - 0.03 14.3 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 Membrane-bound toxin component of toxin-antitoxin system DUF4381 PF14316.6 AIC15802.1 - 0.1 12.8 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Peptidase_M48 PF01435.18 AIC15802.1 - 0.14 11.9 0.1 0.17 11.7 0.1 1.3 1 1 0 1 1 1 0 Peptidase family M48 SNARE PF05739.19 AIC15802.1 - 4.2 7.4 7.7 8.6 6.5 3.8 2.2 2 0 0 2 2 2 0 SNARE domain DUF1297 PF06973.12 AIC15803.1 - 6.2e-76 254.1 0.1 8.2e-76 253.7 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1297) DUF1246 PF06849.12 AIC15803.1 - 4.7e-48 162.2 0.0 1.2e-47 160.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1246) DNase-RNase PF02577.14 AIC15804.1 - 1.3e-09 37.7 0.0 1.5e-09 37.6 0.0 1.1 1 0 0 1 1 1 1 Bifunctional nuclease MerT PF02411.15 AIC15805.1 - 0.016 15.3 3.5 0.016 15.3 3.5 2.8 2 1 0 2 2 2 0 MerT mercuric transport protein CytochromB561_N PF09786.9 AIC15805.1 - 0.043 12.8 0.5 0.073 12.1 0.5 1.3 1 0 0 1 1 1 0 Cytochrome B561, N terminal PDR_assoc PF08370.11 AIC15805.1 - 0.45 10.3 2.3 9.2 6.1 0.3 2.7 2 0 0 2 2 2 0 Plant PDR ABC transporter associated HAD PF12710.7 AIC15806.1 - 1.2e-13 51.9 0.1 2.1e-13 51.1 0.1 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIC15806.1 - 1.6e-09 37.9 0.2 5e-07 29.7 0.0 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIC15806.1 - 4.6e-07 30.3 0.2 0.0032 17.8 0.0 2.5 1 1 1 2 2 2 2 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 AIC15806.1 - 2e-05 24.8 0.8 1.1 9.3 0.4 3.1 2 1 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Put_Phosphatase PF06888.12 AIC15806.1 - 0.00042 19.8 0.0 0.001 18.5 0.0 1.7 1 1 0 1 1 1 1 Putative Phosphatase Hydrolase_like PF13242.6 AIC15806.1 - 0.01 15.8 0.3 0.056 13.5 0.2 2.2 2 1 0 2 2 2 0 HAD-hyrolase-like Cyclotide PF03784.13 AIC15806.1 - 0.069 13.2 0.8 0.13 12.4 0.8 1.3 1 0 0 1 1 1 0 Cyclotide family HTH_46 PF15977.5 AIC15807.1 - 0.0079 16.2 0.2 0.83 9.7 0.0 2.0 2 0 0 2 2 2 2 Winged helix-turn-helix DNA binding PDDEXK_5 PF11645.8 AIC15808.1 - 0.0024 17.9 0.7 0.0096 15.9 0.8 1.8 1 1 1 2 2 2 1 PD-(D/E)XK endonuclease Hep_59 PF07052.11 AIC15810.1 - 0.29 11.9 3.0 0.54 11.0 0.8 2.3 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 DUF4598 PF15370.6 AIC15810.1 - 0.73 10.3 6.1 1.8 9.1 1.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) adh_short PF00106.25 AIC15812.1 - 2.9e-40 137.8 0.1 3.5e-40 137.6 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIC15812.1 - 9.6e-31 107.1 0.0 1.2e-30 106.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIC15812.1 - 2.1e-08 34.3 0.1 2.4e-08 34.1 0.1 1.1 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AIC15812.1 - 0.0037 16.7 0.0 0.045 13.1 0.0 1.9 1 1 0 1 1 1 1 Fungal family of unknown function (DUF1776) RmlD_sub_bind PF04321.17 AIC15812.1 - 0.0093 15.1 0.1 0.013 14.6 0.1 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain Eno-Rase_NADH_b PF12242.8 AIC15812.1 - 0.052 13.3 0.1 0.098 12.4 0.1 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase DUF2950 PF11453.8 AIC15813.1 - 0.071 12.3 0.1 0.077 12.2 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2950) DUF3367 PF11847.8 AIC15815.1 - 0.091 10.6 2.9 0.18 9.7 3.0 1.4 1 1 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase MNE1 PF13762.6 AIC15816.1 - 0.014 15.4 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial splicing apparatus component Big_3_4 PF13754.6 AIC15816.1 - 0.11 12.2 0.0 0.24 11.2 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function CpcD PF01383.21 AIC15817.1 - 0.17 12.2 0.0 0.26 11.6 0.0 1.2 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain zf-A20 PF01754.16 AIC15818.1 - 0.034 14.1 3.5 0.034 14.1 3.5 2.4 2 1 0 2 2 2 0 A20-like zinc finger DUF1351 PF07083.11 AIC15820.1 - 0.0027 17.5 0.1 0.0042 16.9 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1351) zf-RRN7 PF11781.8 AIC15823.1 - 0.079 12.7 0.4 0.26 11.0 0.3 1.8 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Prim_Zn_Ribbon PF08273.12 AIC15823.1 - 1.2 9.4 4.9 8.2 6.8 4.9 2.0 1 1 0 1 1 1 0 Zinc-binding domain of primase-helicase DnaJ_CXXCXGXG PF00684.19 AIC15824.1 - 1.7e-05 25.1 0.1 2.2e-05 24.7 0.1 1.1 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AIC15824.1 - 0.0031 17.4 3.0 0.29 11.1 2.9 2.1 1 1 0 1 1 1 1 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 AIC15824.1 - 0.16 12.2 1.6 8.3 6.7 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5351) zf-C2H2 PF00096.26 AIC15825.1 - 0.0013 19.0 0.0 0.0017 18.7 0.0 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC15825.1 - 0.0072 17.1 0.0 0.009 16.8 0.0 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIC15825.1 - 0.022 15.0 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding zf-C2H2_3 PF13878.6 AIC15825.1 - 0.022 14.6 0.0 0.028 14.3 0.0 1.2 1 0 0 1 1 1 0 zinc-finger of acetyl-transferase ESCO Vps36-NZF-N PF16988.5 AIC15825.1 - 0.026 13.9 0.0 0.027 13.9 0.0 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-C2H2_6 PF13912.6 AIC15825.1 - 0.09 12.8 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2_9 PF16293.5 AIC15825.1 - 0.15 12.0 0.0 0.17 11.8 0.0 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) UbiA PF01040.18 AIC15826.1 - 1.5 8.1 5.3 0.11 11.8 0.3 1.6 2 0 0 2 2 2 0 UbiA prenyltransferase family CsiD PF08943.10 AIC15828.1 - 0.01 15.0 0.1 0.02 14.0 0.1 1.4 1 0 0 1 1 1 0 CsiD Complex1_LYR_2 PF13233.6 AIC15828.1 - 2 9.2 5.3 2.6 8.8 0.0 2.7 2 1 0 2 2 2 0 Complex1_LYR-like EpmC PF04315.12 AIC15829.1 - 0.13 11.9 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Elongation factor P hydroxylase ABM PF03992.16 AIC15830.1 - 1.8e-07 31.2 0.1 2.7e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase MTES_1575 PF18741.1 AIC15830.1 - 0.0069 16.5 0.0 0.0084 16.3 0.0 1.3 1 0 0 1 1 1 1 REase_MTES_1575 GTP_EFTU PF00009.27 AIC15831.1 - 4.4e-54 183.0 0.0 7.5e-54 182.2 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 AIC15831.1 - 3.6e-20 71.9 0.1 2.8e-19 69.1 0.1 2.2 1 1 1 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 AIC15831.1 - 4.2e-19 68.4 0.3 8e-19 67.5 0.3 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 AIC15831.1 - 8.2e-19 67.4 0.0 1.8e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 AIC15831.1 - 4.2e-11 43.1 0.0 1.2e-10 41.6 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AIC15831.1 - 0.0027 17.8 0.1 0.0076 16.3 0.1 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase VitK2_biosynth PF02621.14 AIC15832.1 - 6.4e-73 245.5 0.0 7.2e-73 245.4 0.0 1.0 1 0 0 1 1 1 1 Menaquinone biosynthesis LAGLIDADG_WhiA PF14527.6 AIC15833.1 - 0.14 12.3 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain FAA_hydrolase PF01557.18 AIC15834.1 - 2.3e-69 233.4 0.0 8e-69 231.6 0.0 1.7 2 0 0 2 2 2 1 Fumarylacetoacetate (FAA) hydrolase family FliMN_C PF01052.20 AIC15834.1 - 0.021 14.8 0.1 0.05 13.6 0.1 1.7 1 1 0 1 1 1 0 Type III flagellar switch regulator (C-ring) FliN C-term DUF2437 PF10370.9 AIC15834.1 - 0.074 13.9 0.3 0.41 11.6 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2437) CitMHS PF03600.16 AIC15835.1 - 1e-51 176.0 37.6 1e-51 176.0 37.6 2.3 3 0 0 3 3 3 1 Citrate transporter ArsB PF02040.15 AIC15835.1 - 2.7e-17 63.2 32.2 2.7e-17 63.2 32.2 1.3 1 1 0 1 1 1 1 Arsenical pump membrane protein Na_sulph_symp PF00939.19 AIC15835.1 - 3.5e-12 46.1 41.8 1.1e-09 37.9 11.5 2.7 1 1 2 3 3 3 2 Sodium:sulfate symporter transmembrane region Isochorismatase PF00857.20 AIC15836.1 - 1.1e-31 110.4 0.0 2.8e-31 109.0 0.0 1.7 2 0 0 2 2 2 1 Isochorismatase family Transp_cyt_pur PF02133.15 AIC15837.1 - 1.6e-19 70.1 47.8 2.2e-19 69.5 47.8 1.2 1 0 0 1 1 1 1 Permease for cytosine/purines, uracil, thiamine, allantoin AIRC PF00731.20 AIC15838.1 - 3.5e-49 166.2 0.1 4e-49 166.0 0.1 1.0 1 0 0 1 1 1 1 AIR carboxylase Prok-E2_C PF14459.6 AIC15838.1 - 0.085 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic E2 family C Hydrolase_3 PF08282.12 AIC15838.1 - 0.1 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase UDPG_MGDP_dh_N PF03721.14 AIC15839.1 - 0.031 13.8 0.0 0.032 13.8 0.0 1.0 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Amidase PF01425.21 AIC15840.1 - 7e-120 401.0 0.0 8.4e-120 400.8 0.0 1.1 1 0 0 1 1 1 1 Amidase Glyoxalase_2 PF12681.7 AIC15840.1 - 0.17 11.8 0.2 0.49 10.3 0.2 1.7 1 1 0 1 1 1 0 Glyoxalase-like domain Bmp PF02608.14 AIC15842.1 - 6.2e-54 183.0 0.4 1e-53 182.3 0.4 1.2 1 0 0 1 1 1 1 ABC transporter substrate-binding protein PnrA-like Tenui_PVC2 PF06656.11 AIC15842.1 - 0.12 10.2 0.0 0.17 9.7 0.0 1.1 1 0 0 1 1 1 0 Tenuivirus PVC2 protein BPD_transp_2 PF02653.16 AIC15843.1 - 4.9e-41 140.7 32.5 6.4e-41 140.3 32.5 1.1 1 0 0 1 1 1 1 Branched-chain amino acid transport system / permease component BPD_transp_2 PF02653.16 AIC15844.1 - 2.3e-37 128.6 34.0 2.3e-37 128.6 34.0 1.9 2 0 0 2 2 2 1 Branched-chain amino acid transport system / permease component ABC_tran PF00005.27 AIC15845.1 - 3.5e-52 176.6 0.1 4.4e-30 105.0 0.0 2.2 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 AIC15845.1 - 1.2e-06 28.6 0.2 0.002 18.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 AIC15845.1 - 0.00043 20.2 0.4 0.014 15.3 0.0 2.8 2 0 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 AIC15845.1 - 0.00079 19.1 0.1 0.0025 17.5 0.0 1.8 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_23 PF13476.6 AIC15845.1 - 0.0018 18.8 0.0 0.0035 17.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AIC15845.1 - 0.0026 17.5 0.9 0.046 13.4 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 AIC15845.1 - 0.0044 16.6 0.0 0.0075 15.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 AIC15845.1 - 0.037 13.5 0.1 0.7 9.3 0.0 2.5 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain Bac_DnaA PF00308.18 AIC15845.1 - 0.11 12.3 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein AAA_30 PF13604.6 AIC15845.1 - 0.12 12.1 0.0 0.65 9.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain Ligase_CoA PF00549.19 AIC15846.1 - 2.3e-41 141.1 0.2 2e-39 134.8 0.0 2.3 2 0 0 2 2 2 2 CoA-ligase CoA_binding PF02629.19 AIC15846.1 - 7e-07 29.8 0.2 0.0001 22.9 0.3 2.8 2 0 0 2 2 2 1 CoA binding domain DUF2877 PF11392.8 AIC15848.1 - 2.1e-18 67.0 0.0 5.1e-18 65.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2877) Bmp PF02608.14 AIC15849.1 - 4.5e-52 176.9 1.0 1.8e-26 92.8 0.2 2.6 3 0 0 3 3 3 2 ABC transporter substrate-binding protein PnrA-like AA_kinase PF00696.28 AIC15849.1 - 6.7e-30 104.5 0.1 1.8e-19 70.3 0.0 2.6 2 1 0 2 2 2 2 Amino acid kinase family DUF1116 PF06545.11 AIC15850.1 - 1.4e-79 266.5 0.1 2e-79 266.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1116) Radical_SAM PF04055.21 AIC15851.1 - 1.6e-15 57.9 0.1 3.3e-15 56.9 0.1 1.6 1 0 0 1 1 1 1 Radical SAM superfamily Radical_SAM PF04055.21 AIC15852.1 - 4.7e-18 66.1 0.1 7.4e-18 65.5 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 AIC15853.1 - 5.1e-09 36.4 0.0 4.2e-07 30.2 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIC15853.1 - 3.3e-07 30.6 0.0 7.4e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIC15853.1 - 3.7e-06 26.9 0.0 9.3e-06 25.6 0.0 1.6 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIC15853.1 - 0.00078 19.5 0.0 0.061 13.4 0.0 2.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain UbiD PF01977.16 AIC15854.1 - 1.1e-153 511.9 0.6 1.3e-153 511.7 0.6 1.0 1 0 0 1 1 1 1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DUF4751 PF15942.5 AIC15854.1 - 0.096 12.6 0.9 0.29 11.1 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4751) DDE_Tnp_IS240 PF13610.6 AIC15856.1 - 2.3e-10 40.8 0.1 3.7e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 DDE domain Ribosomal_S24e PF01282.19 AIC15857.1 - 5.2e-13 48.7 0.3 8.3e-13 48.1 0.3 1.4 1 0 0 1 1 1 1 Ribosomal protein S24e Ribosomal_S27 PF01599.19 AIC15858.1 - 4.1e-21 74.9 7.5 6.5e-21 74.2 7.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S27a DUF1451 PF07295.11 AIC15858.1 - 0.0017 18.4 1.6 0.0018 18.3 1.6 1.1 1 0 0 1 1 1 1 Zinc-ribbon containing domain IBR PF01485.21 AIC15858.1 - 0.0035 17.5 0.8 0.0044 17.2 0.8 1.1 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Ribosomal_L37e PF01907.19 AIC15858.1 - 0.0044 17.1 3.4 0.0057 16.8 3.4 1.3 1 0 0 1 1 1 1 Ribosomal protein L37e GFA PF04828.14 AIC15858.1 - 0.0083 16.4 2.6 0.076 13.4 0.2 2.0 1 1 1 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme Ephrin_rec_like PF07699.13 AIC15858.1 - 0.022 14.5 0.8 0.029 14.1 0.8 1.2 1 0 0 1 1 1 0 Putative ephrin-receptor like zinc_ribbon_13 PF09855.9 AIC15858.1 - 0.03 14.5 3.5 0.083 13.1 0.3 2.3 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Nudix_N_2 PF14803.6 AIC15858.1 - 0.031 14.2 1.8 0.15 12.0 1.8 2.0 1 1 0 1 1 1 0 Nudix N-terminal C1_1 PF00130.22 AIC15858.1 - 0.039 13.9 1.8 0.053 13.4 1.8 1.2 1 0 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Baculo_ME53 PF06061.11 AIC15858.1 - 0.053 12.8 2.1 0.057 12.6 2.1 1.0 1 0 0 1 1 1 0 Baculoviridae ME53 DUF2387 PF09526.10 AIC15858.1 - 0.06 13.5 2.0 3.3 7.9 0.1 2.2 1 1 1 2 2 2 0 Probable metal-binding protein (DUF2387) HypA PF01155.19 AIC15858.1 - 0.061 13.3 0.5 0.066 13.2 0.5 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS1595 PF12760.7 AIC15858.1 - 0.071 13.1 3.8 0.88 9.6 4.1 2.0 1 1 2 3 3 3 0 Transposase zinc-ribbon domain zf-Mss51 PF13824.6 AIC15858.1 - 0.1 12.7 1.3 1.5 9.0 1.3 2.1 1 1 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Polbeta PF18765.1 AIC15859.1 - 4.1e-07 30.0 0.0 1e-06 28.7 0.0 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 AIC15859.1 - 1.6e-06 28.3 0.1 4.2e-06 27.0 0.1 1.8 1 1 0 1 1 1 1 Nucleotidyltransferase domain Kdo PF06293.14 AIC15859.1 - 0.0049 16.2 0.0 0.014 14.7 0.0 1.8 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RlaP PF10127.9 AIC15859.1 - 0.031 13.9 1.3 0.044 13.4 0.0 1.9 3 0 0 3 3 3 0 RNA repair pathway DNA polymerase beta family Pkinase PF00069.25 AIC15859.1 - 0.13 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DUF1087 PF06465.13 AIC15862.1 - 0.097 12.7 2.0 7.3 6.7 0.1 2.8 1 1 2 3 3 3 0 Domain of Unknown Function (DUF1087) C5-epim_C PF06662.13 AIC15863.1 - 4.1e-31 107.9 1.5 5.4e-31 107.5 1.5 1.1 1 0 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_88 PF07470.13 AIC15863.1 - 0.0023 17.1 0.2 1.7 7.6 0.0 2.9 1 1 1 3 3 3 3 Glycosyl Hydrolase Family 88 THUMP PF02926.17 AIC15864.1 - 3.8e-06 27.0 0.0 9.5e-06 25.8 0.0 1.6 1 0 0 1 1 1 1 THUMP domain SRP54 PF00448.22 AIC15865.1 - 2.7e-70 236.0 0.2 4.3e-70 235.4 0.2 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 AIC15865.1 - 7.1e-25 87.5 9.2 8.2e-24 84.1 6.3 2.5 2 0 0 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.19 AIC15865.1 - 3.7e-15 55.9 0.3 1e-14 54.5 0.3 1.8 1 0 0 1 1 1 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 AIC15865.1 - 1.4e-06 28.4 0.0 4.4e-06 26.8 0.0 1.8 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_22 PF13401.6 AIC15865.1 - 1.4e-05 25.4 0.1 8.5e-05 22.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain MeaB PF03308.16 AIC15865.1 - 3.6e-05 22.9 1.3 5.9e-05 22.2 0.1 1.9 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB MobB PF03205.14 AIC15865.1 - 7.1e-05 22.7 0.2 0.00018 21.4 0.2 1.7 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B ParA PF10609.9 AIC15865.1 - 0.00018 21.1 0.1 0.00045 19.7 0.1 1.7 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase cobW PF02492.19 AIC15865.1 - 0.00021 21.0 0.9 0.0051 16.4 0.9 2.3 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain APS_kinase PF01583.20 AIC15865.1 - 0.00033 20.6 0.1 0.00075 19.4 0.1 1.6 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_30 PF13604.6 AIC15865.1 - 0.00098 18.9 0.6 0.0024 17.6 0.1 2.0 2 0 0 2 2 1 1 AAA domain MipZ PF09140.11 AIC15865.1 - 0.001 18.4 0.4 0.14 11.4 0.4 2.6 1 1 0 1 1 1 1 ATPase MipZ AAA PF00004.29 AIC15865.1 - 0.0019 18.6 0.0 0.024 15.1 0.0 2.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_31 PF13614.6 AIC15865.1 - 0.0021 18.0 0.2 0.012 15.5 0.1 2.1 1 1 0 1 1 1 1 AAA domain ArsA_ATPase PF02374.15 AIC15865.1 - 0.0031 16.8 2.7 0.024 13.8 0.1 2.9 3 0 0 3 3 3 1 Anion-transporting ATPase AAA_16 PF13191.6 AIC15865.1 - 0.0037 17.7 0.1 0.015 15.7 0.1 2.0 2 0 0 2 2 1 1 AAA ATPase domain MMR_HSR1 PF01926.23 AIC15865.1 - 0.0038 17.3 0.2 0.022 14.9 0.1 2.3 2 1 0 2 2 1 1 50S ribosome-binding GTPase AAA_33 PF13671.6 AIC15865.1 - 0.0038 17.4 0.5 0.0084 16.3 0.0 1.9 2 0 0 2 2 1 1 AAA domain NTPase_1 PF03266.15 AIC15865.1 - 0.0052 16.7 0.8 0.029 14.3 0.8 2.2 1 1 0 1 1 1 1 NTPase CLP1_P PF16575.5 AIC15865.1 - 0.0063 16.3 0.0 0.76 9.5 0.0 3.0 2 1 1 3 3 3 1 mRNA cleavage and polyadenylation factor CLP1 P-loop KTI12 PF08433.10 AIC15865.1 - 0.0068 15.9 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 AIC15865.1 - 0.0084 16.7 0.0 0.034 14.7 0.0 2.2 1 0 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 AIC15865.1 - 0.0085 15.8 0.2 0.024 14.3 0.2 1.7 1 0 0 1 1 1 1 Thymidylate kinase AAA_26 PF13500.6 AIC15865.1 - 0.0098 15.7 0.1 0.52 10.1 0.1 2.5 2 0 0 2 2 2 1 AAA domain AAA_24 PF13479.6 AIC15865.1 - 0.014 15.1 0.0 0.029 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 AIC15865.1 - 0.018 15.5 1.9 0.035 14.5 0.2 2.4 2 1 0 2 2 1 0 AAA domain 6PF2K PF01591.18 AIC15865.1 - 0.019 14.3 0.0 0.053 12.8 0.0 1.8 1 0 0 1 1 1 0 6-phosphofructo-2-kinase LpxK PF02606.14 AIC15865.1 - 0.019 14.1 0.6 0.038 13.1 0.6 1.4 1 0 0 1 1 1 0 Tetraacyldisaccharide-1-P 4'-kinase LPD22 PF18834.1 AIC15865.1 - 0.031 14.5 0.1 0.2 11.9 0.0 2.3 2 0 0 2 2 2 0 Large polyvalent protein associated domain 22 PduV-EutP PF10662.9 AIC15865.1 - 0.038 13.7 0.1 4.6 7.0 0.1 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Radical_SAM_N PF08497.10 AIC15865.1 - 0.05 12.8 0.2 0.27 10.4 0.0 2.0 2 0 0 2 2 2 0 Radical SAM N-terminal ATP_bind_1 PF03029.17 AIC15865.1 - 0.053 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_5 PF07728.14 AIC15865.1 - 0.06 13.4 0.4 0.29 11.1 0.2 2.3 3 0 0 3 3 2 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 AIC15865.1 - 0.069 12.4 0.0 0.13 11.6 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin Mur_ligase_M PF08245.12 AIC15865.1 - 0.085 12.8 0.4 0.2 11.6 0.4 1.7 1 1 0 1 1 1 0 Mur ligase middle domain RNA_helicase PF00910.22 AIC15865.1 - 0.12 12.7 0.0 0.67 10.4 0.0 2.3 1 1 0 1 1 1 0 RNA helicase DUF1611 PF07755.11 AIC15865.1 - 0.14 11.5 0.8 0.26 10.6 0.1 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF1611_C) P-loop domain AAA_28 PF13521.6 AIC15865.1 - 0.14 12.4 0.2 0.3 11.3 0.2 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 AIC15865.1 - 0.2 11.5 0.4 0.84 9.5 0.4 2.1 2 0 0 2 2 2 0 NACHT domain AAA_25 PF13481.6 AIC15865.1 - 0.28 10.8 1.3 1.4 8.4 1.4 2.2 1 1 0 1 1 1 0 AAA domain Diphthami_syn_2 PF01902.17 AIC15866.1 - 1.1e-62 211.5 0.0 1.2e-62 211.3 0.0 1.0 1 0 0 1 1 1 1 Diphthamide synthase QueC PF06508.13 AIC15866.1 - 0.02 14.4 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AIC15866.1 - 0.054 12.3 0.0 0.073 11.9 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase ABC_tran PF00005.27 AIC15867.1 - 5.1e-32 111.3 0.0 6.7e-32 110.9 0.0 1.2 1 0 0 1 1 1 1 ABC transporter oligo_HPY PF08352.12 AIC15867.1 - 3e-06 27.6 0.0 6e-06 26.7 0.0 1.5 1 0 0 1 1 1 1 Oligopeptide/dipeptide transporter, C-terminal region AAA_22 PF13401.6 AIC15867.1 - 1.2e-05 25.7 0.1 7.1e-05 23.1 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC15867.1 - 2.4e-05 24.8 0.0 3.7e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 AIC15867.1 - 0.00028 20.2 0.1 0.00077 18.8 0.0 1.7 1 1 0 1 1 1 1 Zeta toxin AAA PF00004.29 AIC15867.1 - 0.0038 17.6 0.0 0.0066 16.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 AIC15867.1 - 0.0064 16.3 0.4 1.3 8.7 0.1 2.2 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system TIP49 PF06068.13 AIC15867.1 - 0.0093 15.2 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain TsaE PF02367.17 AIC15867.1 - 0.013 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 AIC15867.1 - 0.015 15.3 0.1 0.047 13.7 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 AIC15867.1 - 0.017 14.8 0.6 0.092 12.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 AIC15867.1 - 0.017 14.8 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 AIC15867.1 - 0.023 14.2 0.0 0.049 13.1 0.0 1.5 2 0 0 2 2 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 AIC15867.1 - 0.039 13.7 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 AIC15867.1 - 0.041 14.0 0.1 0.057 13.6 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 AIC15867.1 - 0.043 13.4 0.0 0.11 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 AIC15867.1 - 0.046 12.8 0.1 0.097 11.7 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein GvpD PF07088.11 AIC15867.1 - 0.047 12.3 0.0 0.065 11.8 0.0 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein RsgA_GTPase PF03193.16 AIC15867.1 - 0.052 13.4 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase SRP54 PF00448.22 AIC15867.1 - 0.053 13.1 0.0 0.08 12.6 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain APS_kinase PF01583.20 AIC15867.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Adenylylsulphate kinase PRK PF00485.18 AIC15867.1 - 0.078 12.7 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family IstB_IS21 PF01695.17 AIC15867.1 - 0.091 12.5 0.0 2.3 7.9 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 AIC15867.1 - 0.096 12.4 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 AIC15867.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 AIC15867.1 - 0.13 12.8 0.0 0.23 12.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 AIC15867.1 - 0.15 12.4 0.3 0.35 11.2 0.3 1.7 1 1 0 1 1 1 0 AAA domain SBP_bac_5 PF00496.22 AIC15868.1 - 6.8e-20 71.4 0.4 6.8e-20 71.4 0.4 3.3 3 1 0 3 3 3 1 Bacterial extracellular solute-binding proteins, family 5 Middle Gmad2 PF10648.9 AIC15868.1 - 0.022 15.0 0.0 0.079 13.2 0.0 2.0 1 0 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination TPP_enzyme_N PF02776.18 AIC15868.1 - 0.15 11.7 1.3 0.41 10.2 1.3 1.7 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain BPD_transp_1 PF00528.22 AIC15869.1 - 4.1e-37 127.7 14.1 4.1e-37 127.7 14.1 1.6 2 0 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 AIC15870.1 - 7.7e-27 94.2 9.6 1.9e-26 93.0 9.6 1.7 1 0 0 1 1 1 1 Binding-protein-dependent transport system inner membrane component OppC_N PF12911.7 AIC15870.1 - 0.0012 18.8 0.1 0.0012 18.8 0.1 2.6 3 0 0 3 3 3 1 N-terminal TM domain of oligopeptide transport permease C ABC2_membrane_5 PF13346.6 AIC15870.1 - 4 6.9 9.7 12 5.4 6.4 2.5 2 1 0 2 2 2 0 ABC-2 family transporter protein EFP_N PF08207.12 AIC15871.1 - 2.2e-08 34.0 0.0 2e-06 27.7 0.0 2.4 2 0 0 2 2 2 2 Elongation factor P (EF-P) KOW-like domain eIF-5a PF01287.20 AIC15871.1 - 0.00048 20.2 1.4 0.00066 19.7 1.4 1.2 1 0 0 1 1 1 1 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GH101_N PF17995.1 AIC15871.1 - 0.029 14.0 0.1 0.044 13.4 0.1 1.2 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase N-terminal CorA PF01544.18 AIC15874.1 - 6.3e-56 189.8 0.4 7.2e-56 189.6 0.4 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein MnmE_helical PF12631.7 AIC15874.1 - 0.037 14.2 1.1 0.52 10.4 0.1 2.0 1 1 1 2 2 2 0 MnmE helical domain ALAD PF00490.21 AIC15875.1 - 9.4e-113 376.5 3.3 1.1e-112 376.3 3.3 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase Aldedh PF00171.22 AIC15876.1 - 4e-146 487.2 0.2 4.5e-146 487.0 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 AIC15876.1 - 0.00084 18.5 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) ADH_N PF08240.12 AIC15878.1 - 3e-33 114.0 0.2 5.1e-33 113.2 0.2 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIC15878.1 - 5.5e-27 94.3 2.3 7.3e-27 93.9 0.5 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 AIC15878.1 - 8.3e-15 56.0 0.3 1.5e-14 55.2 0.0 1.6 2 0 0 2 2 1 1 Zinc-binding dehydrogenase Glu_dehyd_C PF16912.5 AIC15878.1 - 1.9e-05 24.3 0.9 9.4e-05 22.0 0.9 1.8 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus AlaDh_PNT_C PF01262.21 AIC15878.1 - 0.00013 21.4 3.0 0.00019 20.8 3.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain PglD_N PF17836.1 AIC15878.1 - 0.0061 17.2 1.3 0.012 16.2 1.3 1.5 1 0 0 1 1 1 1 PglD N-terminal domain Pyr_redox PF00070.27 AIC15878.1 - 0.0065 17.0 0.4 0.29 11.7 0.7 2.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 AIC15878.1 - 0.016 15.5 0.3 0.031 14.5 0.3 1.5 1 0 0 1 1 1 0 TrkA-N domain UDPG_MGDP_dh_N PF03721.14 AIC15878.1 - 0.016 14.8 0.7 0.025 14.1 0.7 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 AIC15878.1 - 0.018 14.4 0.4 0.043 13.2 0.4 1.6 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Glyco_hydro_4 PF02056.16 AIC15878.1 - 0.063 12.8 0.1 0.1 12.2 0.1 1.3 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase Spermine_synth PF01564.17 AIC15878.1 - 0.072 12.5 0.2 0.13 11.7 0.2 1.4 1 0 0 1 1 1 0 Spermine/spermidine synthase domain DUF488 PF04343.13 AIC15879.1 - 4.2e-26 91.9 0.1 4.7e-26 91.8 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function, DUF488 Pox_A14 PF05767.12 AIC15880.1 - 0.085 13.0 1.1 0.96 9.6 0.0 2.6 3 0 0 3 3 3 0 Poxvirus virion envelope protein A14 DUF5423 PF17461.2 AIC15880.1 - 0.39 9.5 1.4 0.61 8.9 1.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Lyase_1 PF00206.20 AIC15881.1 - 4.5e-92 308.8 0.4 5.7e-92 308.4 0.4 1.1 1 0 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 AIC15881.1 - 4.2e-20 71.9 1.9 7.4e-20 71.1 0.5 2.3 2 0 0 2 2 2 1 Fumarase C C-terminus DUF4316 PF14195.6 AIC15881.1 - 0.013 15.3 0.2 2 8.2 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4316) DUF1062 PF06353.12 AIC15881.1 - 0.13 13.1 0.1 0.4 11.5 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1062) Acetyltransf_3 PF13302.7 AIC15882.1 - 1.1e-31 110.4 0.0 1.3e-31 110.1 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 AIC15882.1 - 2e-14 54.0 0.1 2.6e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 AIC15882.1 - 2.3e-10 40.8 0.2 3.2e-10 40.3 0.2 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_8 PF13523.6 AIC15882.1 - 0.003 17.3 0.0 0.0042 16.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF2079 PF09852.9 AIC15883.1 - 0.053 12.4 3.8 0.063 12.1 3.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2079) Flp1_like PF16982.5 AIC15883.1 - 0.11 11.9 2.9 0.24 10.8 0.1 2.4 2 0 0 2 2 2 0 Putative Flagellin, Flp1-like, domain DUF4231 PF14015.6 AIC15883.1 - 5.1 7.6 5.7 4.2 7.9 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF543 PF04418.12 AIC15883.1 - 8.1 6.5 7.4 4.2 7.4 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF543) DUF2182 PF09948.9 AIC15884.1 - 5e-58 196.1 19.4 5e-58 196.1 19.4 2.3 2 1 0 2 2 2 1 Predicted metal-binding integral membrane protein (DUF2182) DHHC PF01529.20 AIC15884.1 - 4.2 7.5 6.6 8.4 6.5 0.5 2.4 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF1326 PF07040.11 AIC15885.1 - 3.3e-51 173.8 0.0 3.9e-51 173.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) Arnt_C PF18583.1 AIC15886.1 - 0.00072 19.1 0.6 0.0014 18.3 0.6 1.5 1 1 0 1 1 1 1 Aminoarabinose transferase C-terminal domain DUF1326 PF07040.11 AIC15887.1 - 8.8e-55 185.5 0.0 1e-54 185.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) 2-Hacid_dh_C PF02826.19 AIC15889.1 - 4e-67 225.0 0.0 1.6e-66 223.1 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 AIC15889.1 - 1.1e-29 102.7 0.4 1.3e-29 102.6 0.4 1.0 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 AIC15889.1 - 3.2e-06 27.4 0.3 2.3e-05 24.6 0.0 2.1 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase AdoHcyase_NAD PF00670.21 AIC15889.1 - 0.014 15.4 0.1 0.093 12.8 0.0 2.0 2 0 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain XdhC_C PF13478.6 AIC15889.1 - 0.019 15.5 0.0 0.19 12.3 0.0 2.4 2 1 0 2 2 2 0 XdhC Rossmann domain Ribosomal_L15e PF00827.17 AIC15890.1 - 1.8e-49 168.1 3.8 2.1e-49 167.8 3.8 1.0 1 0 0 1 1 1 1 Ribosomal L15 zf-CDGSH PF09360.10 AIC15892.1 - 1.7e-39 133.8 1.9 2.2e-19 69.4 0.1 2.6 2 0 0 2 2 2 2 Iron-binding zinc finger CDGSH type Fer4_19 PF06902.11 AIC15892.1 - 4.3e-06 26.7 0.1 1.3e-05 25.2 0.0 1.9 2 0 0 2 2 2 1 Divergent 4Fe-4S mono-cluster zf-UBR PF02207.20 AIC15892.1 - 0.049 13.8 4.1 4.3 7.6 0.1 2.3 2 0 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) Tecti-min-caps PF09300.10 AIC15892.1 - 0.18 11.9 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 Tectiviridae, minor capsid ADH_zinc_N_2 PF13602.6 AIC15893.1 - 8.5e-27 94.8 0.0 1.6e-26 93.9 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 AIC15893.1 - 1.8e-17 63.5 0.3 3.8e-17 62.5 0.3 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIC15893.1 - 3.2e-09 36.6 0.0 6.8e-09 35.6 0.0 1.6 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain AlaDh_PNT_C PF01262.21 AIC15893.1 - 0.00017 21.0 0.3 0.00034 20.0 0.3 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain YAcAr PF10686.9 AIC15893.1 - 0.015 15.3 0.0 0.05 13.5 0.0 2.0 1 1 0 1 1 1 0 YspA, cpYpsA-related SLOG family 2-Hacid_dh_C PF02826.19 AIC15893.1 - 0.07 12.5 0.2 0.13 11.6 0.2 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain BppU_IgG PF18667.1 AIC15893.1 - 0.088 13.0 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 Baseplate upper protein immunoglobulin like domain ELFV_dehydrog PF00208.21 AIC15893.1 - 0.15 11.7 4.6 0.24 11.1 1.0 2.6 2 1 1 3 3 3 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Nitroreductase PF00881.24 AIC15894.1 - 5.5e-24 85.1 0.4 5e-12 46.2 0.0 2.1 2 0 0 2 2 2 2 Nitroreductase family TM1586_NiRdase PF14512.6 AIC15894.1 - 1.1e-07 31.6 0.0 0.0006 19.4 0.0 2.1 1 1 1 2 2 2 2 Putative TM nitroreductase Methyltransf_2 PF00891.18 AIC15895.1 - 2.7e-33 115.1 0.2 3.5e-33 114.7 0.2 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_23 PF13489.6 AIC15895.1 - 2.4e-08 34.0 0.0 4.3e-08 33.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15895.1 - 1.8e-05 25.3 0.1 4.2e-05 24.2 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15895.1 - 2.3e-05 25.0 0.0 5.3e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC15895.1 - 6.1e-05 22.9 0.0 9.2e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIC15895.1 - 0.00011 21.8 0.0 0.00018 21.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Dimerisation2 PF16864.5 AIC15895.1 - 0.00025 21.0 0.0 0.00066 19.6 0.0 1.8 1 0 0 1 1 1 1 Dimerisation domain DUF938 PF06080.12 AIC15895.1 - 0.0081 15.9 0.0 0.021 14.6 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF938) Methyltransf_16 PF10294.9 AIC15895.1 - 0.014 15.1 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 Lysine methyltransferase Glyco_hydro_66 PF13199.6 AIC15895.1 - 0.022 13.4 0.0 0.032 12.9 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Methyltransf_11 PF08241.12 AIC15895.1 - 0.052 14.2 0.0 0.095 13.4 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_9 PF08003.11 AIC15895.1 - 0.062 12.2 0.0 0.092 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PrmA PF06325.13 AIC15895.1 - 0.15 11.4 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 AIC15896.1 - 2.4e-12 47.3 0.0 3.9e-12 46.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15896.1 - 1.7e-07 31.8 0.0 2.8e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15896.1 - 2.7e-05 24.1 0.0 4.4e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 AIC15896.1 - 0.0003 20.2 0.0 0.00061 19.2 0.0 1.5 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 AIC15896.1 - 0.0016 18.1 0.1 0.0097 15.5 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_12 PF08242.12 AIC15896.1 - 0.0019 18.9 0.0 0.004 17.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_8 PF05148.15 AIC15896.1 - 0.028 14.3 0.0 0.042 13.7 0.0 1.3 1 0 0 1 1 1 0 Hypothetical methyltransferase Methyltransf_2 PF00891.18 AIC15896.1 - 0.058 12.7 0.0 0.43 9.8 0.0 2.0 1 1 0 1 1 1 0 O-methyltransferase domain DUF4367 PF14285.6 AIC15897.1 - 0.012 16.0 0.3 0.017 15.5 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4367) Adeno_E3 PF06040.11 AIC15898.1 - 0.25 11.5 0.8 0.7 10.1 0.2 2.0 2 0 0 2 2 2 0 Adenovirus E3 protein DUF677 PF05055.12 AIC15898.1 - 0.28 10.0 3.6 1.2 8.0 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF677) LapA_dom PF06305.11 AIC15898.1 - 3.9 7.3 0.0 3.9 7.3 0.0 3.2 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain HTH_AsnC-type PF13404.6 AIC15899.1 - 4.7e-16 58.3 0.8 9e-16 57.4 0.3 1.7 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HTH_24 PF13412.6 AIC15899.1 - 2e-15 56.1 0.5 5.2e-15 54.7 0.3 1.8 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding AsnC_trans_reg PF01037.21 AIC15899.1 - 4.9e-11 42.4 0.2 7.8e-11 41.8 0.2 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIC15899.1 - 3.3e-06 27.1 3.9 7.3e-05 22.7 0.9 2.2 2 0 0 2 2 2 1 NapD protein HTH_5 PF01022.20 AIC15899.1 - 5.5e-05 22.9 0.0 0.00039 20.2 0.0 2.3 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 AIC15899.1 - 0.00028 20.8 0.2 0.00073 19.4 0.2 1.7 1 0 0 1 1 1 1 HTH domain HTH_IclR PF09339.10 AIC15899.1 - 0.00047 19.9 0.0 0.0011 18.8 0.0 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain MarR_2 PF12802.7 AIC15899.1 - 0.00049 19.9 0.3 0.0022 17.8 0.1 2.0 1 1 1 2 2 2 1 MarR family HTH_Tnp_ISL3 PF13542.6 AIC15899.1 - 0.003 16.9 0.0 0.0092 15.4 0.0 1.9 2 0 0 2 2 2 1 Helix-turn-helix domain of transposase family ISL3 TrmB PF01978.19 AIC15899.1 - 0.0041 17.0 0.3 0.043 13.7 0.0 2.1 1 1 1 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIC15899.1 - 0.014 15.3 0.4 0.044 13.7 0.1 1.9 2 0 0 2 2 2 0 MarR family HTH_20 PF12840.7 AIC15899.1 - 0.016 15.3 0.0 0.042 13.9 0.0 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_47 PF16221.5 AIC15899.1 - 0.016 14.8 0.1 0.044 13.4 0.1 1.7 1 0 0 1 1 1 0 winged helix-turn-helix GYD PF08734.11 AIC15899.1 - 0.045 13.7 0.1 0.11 12.4 0.1 1.6 1 1 0 1 1 1 0 GYD domain CinA_KH PF18146.1 AIC15899.1 - 0.063 13.4 0.5 0.14 12.4 0.1 1.8 2 0 0 2 2 2 0 Damage-inducible protein CinA KH domain Sigma70_r4 PF04545.16 AIC15899.1 - 0.065 12.8 0.0 0.16 11.5 0.0 1.8 1 0 0 1 1 1 0 Sigma-70, region 4 FaeA PF04703.12 AIC15899.1 - 0.073 13.5 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 FaeA-like protein HTH_6 PF01418.17 AIC15899.1 - 0.1 12.6 0.2 0.1 12.6 0.2 2.5 2 1 1 3 3 3 0 Helix-turn-helix domain, rpiR family HTH_36 PF13730.6 AIC15899.1 - 0.15 12.0 0.0 0.6 10.1 0.0 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain Aminotran_3 PF00202.21 AIC15900.1 - 3e-114 381.8 0.1 4.2e-114 381.4 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 AIC15900.1 - 0.00013 21.3 0.0 0.00043 19.6 0.0 1.7 2 0 0 2 2 2 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AIC15900.1 - 0.00062 18.8 0.0 0.00093 18.3 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-V AA_kinase PF00696.28 AIC15901.1 - 1.6e-38 132.7 4.7 1.8e-38 132.5 4.7 1.0 1 0 0 1 1 1 1 Amino acid kinase family Semialdhyde_dh PF01118.24 AIC15902.1 - 5.6e-38 130.1 0.0 1.1e-37 129.1 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Semialdhyde_dhC PF02774.18 AIC15902.1 - 1.5e-22 80.6 0.0 2.2e-22 80.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain F420_oxidored PF03807.17 AIC15902.1 - 0.00015 22.2 0.0 0.00035 21.1 0.0 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent DapB_N PF01113.20 AIC15902.1 - 0.00069 19.7 0.1 0.0015 18.6 0.1 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus NAD_binding_10 PF13460.6 AIC15902.1 - 0.003 17.5 0.0 0.0067 16.3 0.0 1.6 1 0 0 1 1 1 1 NAD(P)H-binding GFO_IDH_MocA PF01408.22 AIC15902.1 - 0.011 16.6 0.0 0.021 15.6 0.0 1.5 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold Sacchrp_dh_NADP PF03435.18 AIC15902.1 - 0.022 15.0 0.0 0.04 14.2 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Epimerase PF01370.21 AIC15902.1 - 0.065 12.7 0.0 0.1 12.1 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family RPN6_N PF18055.1 AIC15902.1 - 0.068 13.5 0.0 0.28 11.6 0.0 1.9 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain Ldh_1_N PF00056.23 AIC15902.1 - 0.12 12.4 0.0 0.26 11.4 0.0 1.6 1 0 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain RimK PF08443.11 AIC15903.1 - 3.2e-36 124.7 0.0 4.1e-36 124.3 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 AIC15903.1 - 3.8e-13 49.2 0.0 5.8e-13 48.6 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 AIC15903.1 - 1.4e-10 41.5 0.0 6.1e-10 39.4 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain ATPgrasp_ST PF14397.6 AIC15903.1 - 1.5e-08 34.2 0.0 0.00096 18.5 0.0 2.6 2 1 1 3 3 3 2 Sugar-transfer associated ATP-grasp ATP-grasp PF02222.22 AIC15903.1 - 7.4e-07 28.9 0.0 1.7e-06 27.7 0.0 1.5 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_YheCD PF14398.6 AIC15903.1 - 2.2e-06 27.1 0.0 0.068 12.4 0.0 3.0 1 1 1 2 2 2 2 YheC/D like ATP-grasp CPSase_L_D2 PF02786.17 AIC15903.1 - 0.00011 21.7 0.0 0.00022 20.8 0.0 1.5 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_5 PF13549.6 AIC15903.1 - 0.0017 17.8 0.0 0.0043 16.5 0.0 1.6 2 0 0 2 2 2 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 AIC15903.1 - 0.019 14.5 0.0 0.052 13.1 0.0 1.8 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus GARS_A PF01071.19 AIC15903.1 - 0.1 12.4 0.0 0.4 10.4 0.0 1.8 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain zinc_ribbon_4 PF13717.6 AIC15904.1 - 2.6e-05 24.1 0.7 0.16 11.9 0.1 2.1 1 1 1 2 2 2 2 zinc-ribbon domain zf-IS66 PF13005.7 AIC15904.1 - 0.00027 21.3 1.4 0.047 14.1 0.1 2.1 2 0 0 2 2 2 1 zinc-finger binding domain of transposase IS66 Zn-ribbon_8 PF09723.10 AIC15904.1 - 0.0013 18.8 7.7 0.018 15.1 2.8 1.9 1 1 1 2 2 2 2 Zinc ribbon domain YhfH PF14149.6 AIC15904.1 - 0.0014 18.5 4.0 0.037 14.0 0.7 2.2 2 0 0 2 2 2 1 YhfH-like protein zf-ribbon_3 PF13248.6 AIC15904.1 - 0.0031 16.9 2.2 0.98 8.9 0.2 2.1 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 AIC15904.1 - 0.0048 16.9 0.3 0.0058 16.6 0.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_9 PF14369.6 AIC15904.1 - 0.0073 16.5 1.5 0.015 15.6 1.5 1.5 1 1 0 1 1 1 1 zinc-ribbon zinc_ribbon_5 PF13719.6 AIC15904.1 - 0.01 15.6 0.7 0.073 12.8 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain zf-C4_Topoisom PF01396.19 AIC15904.1 - 0.01 15.6 1.6 1.1 9.2 0.0 2.1 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger HypA PF01155.19 AIC15904.1 - 0.011 15.7 0.4 0.012 15.7 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_UBZ PF18439.1 AIC15904.1 - 0.017 14.7 1.4 4 7.1 0.3 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DUF1272 PF06906.11 AIC15904.1 - 0.018 15.1 4.3 1.1 9.4 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1272) PhnA_Zn_Ribbon PF08274.12 AIC15904.1 - 0.024 14.6 0.1 0.045 13.7 0.1 1.4 1 1 0 1 1 1 0 PhnA Zinc-Ribbon DNA_RNApol_7kD PF03604.13 AIC15904.1 - 0.026 14.2 4.7 0.56 9.9 4.0 2.7 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit zf_Rg PF17915.1 AIC15904.1 - 0.029 13.8 0.8 0.36 10.3 0.0 2.1 2 0 0 2 2 2 0 Reverse gyrase zinc finger zf-HYPF PF07503.12 AIC15904.1 - 0.048 13.4 1.9 0.57 10.0 1.9 2.0 1 1 0 1 1 1 0 HypF finger Prok-RING_1 PF14446.6 AIC15904.1 - 0.06 13.3 7.6 0.3 11.1 7.6 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 OrfB_Zn_ribbon PF07282.11 AIC15904.1 - 0.061 13.3 0.2 0.086 12.8 0.2 1.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain DUF1451 PF07295.11 AIC15904.1 - 0.064 13.3 0.6 0.092 12.8 0.6 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain Lar_restr_allev PF14354.6 AIC15904.1 - 0.07 13.5 1.8 0.18 12.2 1.8 1.7 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-RING_7 PF02591.15 AIC15904.1 - 0.1 12.8 0.4 0.1 12.8 0.4 2.6 3 0 0 3 3 3 0 C4-type zinc ribbon domain Nop10p PF04135.12 AIC15904.1 - 0.1 12.6 0.7 15 5.7 0.1 2.2 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family CpXC PF14353.6 AIC15904.1 - 0.13 12.3 1.0 3.4 7.7 0.1 2.0 1 1 1 2 2 2 0 CpXC protein DUF983 PF06170.12 AIC15904.1 - 0.18 12.2 2.9 5.5 7.5 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF983) PADR1 PF08063.12 AIC15904.1 - 0.3 10.9 2.9 0.82 9.5 0.1 2.0 1 1 1 2 2 2 0 PADR1 (NUC008) domain Arginosuc_synth PF00764.19 AIC15905.1 - 7.9e-161 535.7 0.2 9.1e-161 535.5 0.2 1.0 1 0 0 1 1 1 1 Arginosuccinate synthase Asn_synthase PF00733.21 AIC15905.1 - 0.00096 18.9 0.0 0.0015 18.3 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase QueC PF06508.13 AIC15905.1 - 0.058 12.9 0.1 0.14 11.7 0.0 1.7 2 0 0 2 2 2 0 Queuosine biosynthesis protein QueC ACT_7 PF13840.6 AIC15906.1 - 4.5e-06 26.4 0.0 1.1e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 ACT domain ECH_2 PF16113.5 AIC15906.1 - 0.0019 17.7 0.1 0.0026 17.3 0.1 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase B12-binding_2 PF02607.17 AIC15909.1 - 3e-08 34.0 0.2 6.3e-08 33.0 0.2 1.6 1 0 0 1 1 1 1 B12 binding domain HTH_11 PF08279.12 AIC15909.1 - 1.4e-06 28.1 0.0 2.5e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 AIC15909.1 - 1.2e-05 24.7 0.1 2.1e-05 24.0 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding DUF2250 PF10007.9 AIC15909.1 - 0.00047 20.2 0.1 0.0009 19.3 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2250) MarR PF01047.22 AIC15909.1 - 0.005 16.7 0.1 0.0096 15.8 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_5 PF01022.20 AIC15909.1 - 0.0054 16.6 0.0 0.011 15.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family GntR PF00392.21 AIC15909.1 - 0.01 15.5 0.0 0.022 14.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family RepL PF05732.11 AIC15909.1 - 0.052 13.0 0.2 0.095 12.1 0.2 1.3 1 0 0 1 1 1 0 Firmicute plasmid replication protein (RepL) HTH_IclR PF09339.10 AIC15909.1 - 0.066 13.0 0.0 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 IclR helix-turn-helix domain Mnd1 PF03962.15 AIC15909.1 - 0.079 13.3 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 Mnd1 HTH domain Dimerisation2 PF16864.5 AIC15909.1 - 0.16 11.9 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain Yip1 PF04893.17 AIC15910.1 - 0.2 11.4 26.6 0.29 10.8 26.6 1.3 1 0 0 1 1 1 0 Yip1 domain DUF2070 PF09843.9 AIC15910.1 - 3.5 5.8 15.8 4.3 5.5 15.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) FUN14 PF04930.15 AIC15911.1 - 5.3e-20 71.6 6.6 6.4e-20 71.4 6.6 1.1 1 0 0 1 1 1 1 FUN14 family TAP35_44 PF07265.11 AIC15911.1 - 0.069 13.2 0.1 0.08 13.0 0.1 1.1 1 0 0 1 1 1 0 Tapetum specific protein TAP35/TAP44 Vma12 PF11712.8 AIC15911.1 - 0.11 12.6 3.7 2.9 8.0 2.4 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4231 PF14015.6 AIC15911.1 - 0.56 10.7 4.3 0.38 11.2 2.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) DUF3149 PF11346.8 AIC15911.1 - 1.2 8.9 6.2 0.34 10.6 0.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3149) SPC12 PF06645.13 AIC15911.1 - 1.6 8.8 9.2 0.68 10.1 4.8 2.2 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Trp_oprn_chp PF09534.10 AIC15911.1 - 2.4 7.9 8.9 2.8 7.7 8.9 1.1 1 0 0 1 1 1 0 Tryptophan-associated transmembrane protein (Trp_oprn_chp) SLATT_1 PF18181.1 AIC15911.1 - 2.6 8.0 4.3 2.9 7.8 2.7 1.8 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 DUF3416 PF11896.8 AIC15912.1 - 0.072 13.4 1.7 0.075 13.3 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3416) DUF4446 PF14584.6 AIC15912.1 - 0.23 11.4 13.0 0.8 9.7 4.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) Med30 PF11315.8 AIC15912.1 - 0.3 11.3 11.8 0.22 11.7 7.3 2.3 1 1 1 2 2 2 0 Mediator complex subunit 30 SpecificRecomb PF10136.9 AIC15912.1 - 0.49 8.7 1.6 0.64 8.2 1.6 1.1 1 0 0 1 1 1 0 Site-specific recombinase EzrA PF06160.12 AIC15912.1 - 0.56 8.3 21.4 0.43 8.7 10.0 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF3665 PF12427.8 AIC15912.1 - 0.62 9.8 0.1 0.62 9.8 0.1 2.5 3 0 0 3 3 3 0 Branched-chain amino acid aminotransferase FlpD PF02662.16 AIC15912.1 - 0.94 9.5 3.3 20 5.2 0.0 2.4 2 1 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit Syntaxin_2 PF14523.6 AIC15912.1 - 1.4 9.3 9.7 8.8 6.8 8.5 2.6 1 1 0 1 1 1 0 Syntaxin-like protein V_ATPase_I PF01496.19 AIC15912.1 - 2.6 5.9 9.4 3.1 5.6 9.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ThiD2 PF17792.1 AIC15912.1 - 2.6 8.5 12.4 0.29 11.6 6.5 2.2 2 1 1 3 3 3 0 ThiD2 family DUF4795 PF16043.5 AIC15912.1 - 6.6 6.3 19.7 1.1e+03 -0.9 19.7 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Atg14 PF10186.9 AIC15912.1 - 9.1 5.3 18.1 22 4.0 18.2 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Methyltransf_31 PF13847.6 AIC15913.1 - 7.2e-22 77.8 0.0 8.4e-22 77.6 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC15913.1 - 1.3e-20 73.8 0.0 3.4e-20 72.5 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15913.1 - 2.6e-19 69.7 0.0 5.7e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15913.1 - 8e-14 51.8 0.0 1e-13 51.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15913.1 - 4.5e-11 43.4 0.0 7.4e-11 42.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC15913.1 - 3.8e-09 36.2 0.0 5.2e-09 35.8 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MTS PF05175.14 AIC15913.1 - 2.2e-05 24.0 0.0 3.3e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 AIC15913.1 - 0.00031 20.5 0.0 0.00044 20.1 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 AIC15913.1 - 0.00044 19.6 0.0 0.0006 19.2 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_32 PF13679.6 AIC15913.1 - 0.001 19.1 0.0 0.0016 18.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 AIC15913.1 - 0.0035 16.8 0.0 0.0066 15.9 0.0 1.4 1 1 0 1 1 1 1 Putative methyltransferase TehB PF03848.14 AIC15913.1 - 0.0077 15.7 0.0 0.012 15.0 0.0 1.2 1 0 0 1 1 1 1 Tellurite resistance protein TehB MetW PF07021.12 AIC15913.1 - 0.012 15.2 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW PrmA PF06325.13 AIC15913.1 - 0.013 14.9 0.0 0.019 14.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 AIC15913.1 - 0.042 13.1 0.0 0.068 12.5 0.0 1.4 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Polyketide_cyc2 PF10604.9 AIC15914.1 - 0.023 15.0 0.0 0.023 15.0 0.0 1.0 1 0 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport COMM_domain PF07258.14 AIC15914.1 - 0.099 12.8 0.0 0.1 12.7 0.0 1.0 1 0 0 1 1 1 0 COMM domain eIF-1a PF01176.19 AIC15915.1 - 4.4e-20 71.2 1.0 5.5e-20 70.9 1.0 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.19 AIC15915.1 - 0.00022 21.0 0.6 0.0018 18.1 0.2 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain RsgA_N PF16745.5 AIC15915.1 - 0.0045 16.7 0.4 0.0071 16.1 0.4 1.4 1 0 0 1 1 1 1 RsgA N-terminal domain Prot_ATP_ID_OB PF16450.5 AIC15915.1 - 0.015 15.3 0.0 0.023 14.7 0.0 1.2 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain Ribosomal_60s PF00428.19 AIC15916.1 - 4.2e-18 65.7 13.2 5.1e-18 65.5 13.2 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein zinc_ribbon_5 PF13719.6 AIC15918.1 - 0.013 15.3 0.9 0.035 13.9 0.9 1.7 1 1 0 1 1 1 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 AIC15918.1 - 0.054 12.9 0.6 5.7 6.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain CpXC PF14353.6 AIC15918.1 - 0.15 12.1 1.2 1.9 8.6 0.7 2.4 2 1 0 2 2 2 0 CpXC protein Zn_Tnp_IS1595 PF12760.7 AIC15918.1 - 0.2 11.7 2.3 0.58 10.2 2.3 1.8 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zinc_ribbon_4 PF13717.6 AIC15918.1 - 3.7 7.6 7.1 55 3.8 7.1 2.3 1 1 0 1 1 1 0 zinc-ribbon domain RL10P_insert PF17777.1 AIC15919.1 - 3.3e-20 71.8 0.1 6.9e-20 70.8 0.1 1.6 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_L10 PF00466.20 AIC15919.1 - 6.6e-20 71.1 2.6 1e-19 70.5 1.5 1.9 2 0 0 2 2 2 1 Ribosomal protein L10 Ribosomal_L1 PF00687.21 AIC15920.1 - 5.7e-37 127.4 0.0 7.1e-37 127.1 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family Polysacc_deac_1 PF01522.21 AIC15921.1 - 4.3e-11 42.8 0.0 8.4e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIC15921.1 - 2.6e-07 30.5 0.1 5.1e-07 29.6 0.0 1.6 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 AIC15921.1 - 0.022 14.0 0.0 0.029 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 TIR-like PF10137.9 AIC15921.1 - 0.1 12.6 0.1 0.97 9.4 0.0 2.4 3 0 0 3 3 3 0 Predicted nucleotide-binding protein containing TIR-like domain Alkyl_sulf_dimr PF14863.6 AIC15921.1 - 0.14 12.7 0.0 0.27 11.7 0.0 1.4 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation RAP PF08373.10 AIC15921.1 - 0.16 12.1 0.5 0.4 10.8 0.5 1.7 1 0 0 1 1 1 0 RAP domain Glycos_transf_2 PF00535.26 AIC15922.1 - 5.2e-10 39.4 0.0 7.8e-09 35.6 0.0 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIC15922.1 - 0.00033 20.6 0.0 0.00046 20.1 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Piwi PF02171.17 AIC15922.1 - 0.13 11.5 0.0 0.21 10.8 0.0 1.3 1 0 0 1 1 1 0 Piwi domain UPF0164 PF03687.13 AIC15922.1 - 0.19 10.5 0.0 0.27 10.0 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0164) Hexapep PF00132.24 AIC15923.1 - 1e-28 98.0 26.1 4e-11 42.2 6.7 4.1 4 0 0 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AIC15923.1 - 1.7e-15 56.4 23.0 4.1e-08 32.8 0.4 4.2 3 1 1 4 4 4 3 Hexapeptide repeat of succinyl-transferase DUF4954 PF16314.5 AIC15923.1 - 0.0025 16.0 1.6 0.0032 15.7 1.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4954) Fucokinase PF07959.12 AIC15923.1 - 0.079 11.9 0.1 0.43 9.5 0.1 2.0 1 1 0 1 1 1 0 L-fucokinase ApoLp-III PF07464.11 AIC15926.1 - 0.0015 18.6 0.6 0.0025 17.9 0.6 1.2 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) Baculo_PEP_C PF04513.12 AIC15926.1 - 0.002 18.2 2.1 0.0032 17.5 2.1 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus YtkA PF13115.6 AIC15926.1 - 0.0071 16.9 0.0 0.056 14.1 0.0 2.3 3 0 0 3 3 3 1 YtkA-like FlgD_ig PF13860.6 AIC15926.1 - 0.0082 16.0 0.0 0.032 14.1 0.0 2.0 1 0 0 1 1 1 1 FlgD Ig-like domain DUF1664 PF07889.12 AIC15926.1 - 0.012 15.6 0.6 0.022 14.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 AIC15926.1 - 0.018 15.3 0.1 0.039 14.2 0.1 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Lipoprotein_2 PF00921.17 AIC15926.1 - 0.029 14.0 0.2 0.043 13.4 0.2 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein Cob_adeno_trans PF01923.18 AIC15926.1 - 0.031 14.4 0.1 0.045 13.9 0.1 1.2 1 0 0 1 1 1 0 Cobalamin adenosyltransferase Filament PF00038.21 AIC15926.1 - 0.04 13.5 0.1 0.054 13.1 0.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 AIC15926.1 - 0.041 14.0 0.4 0.067 13.3 0.4 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein PurA PF04845.13 AIC15926.1 - 0.042 13.2 0.2 0.067 12.5 0.2 1.3 1 0 0 1 1 1 0 PurA ssDNA and RNA-binding protein SHE3 PF17078.5 AIC15926.1 - 0.1 12.3 0.1 0.14 11.8 0.1 1.1 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 Fzo_mitofusin PF04799.13 AIC15926.1 - 0.11 12.0 0.5 0.2 11.2 0.5 1.3 1 0 0 1 1 1 0 fzo-like conserved region TMF_TATA_bd PF12325.8 AIC15926.1 - 0.17 12.1 1.3 0.25 11.5 1.3 1.2 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Syntaxin-6_N PF09177.11 AIC15926.1 - 0.18 12.3 1.0 0.31 11.6 1.0 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DUF4519 PF15012.6 AIC15926.1 - 0.19 11.9 1.7 0.42 10.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) SoxZ PF08770.11 AIC15927.1 - 0.044 13.6 4.4 0.11 12.3 0.1 3.8 4 0 0 4 4 4 0 Sulphur oxidation protein SoxZ Cupredoxin_1 PF13473.6 AIC15927.1 - 0.35 11.0 3.4 4.6 7.4 0.1 4.2 4 1 0 4 4 4 0 Cupredoxin-like domain BclA_C PF18573.1 AIC15930.1 - 0.00034 20.5 3.3 0.00068 19.5 3.3 1.5 1 0 0 1 1 1 1 BclA C-terminal domain Ntox14 PF15522.6 AIC15930.1 - 0.094 12.1 0.1 3.1 7.2 0.1 2.1 2 0 0 2 2 2 0 Novel toxin 14 HigB_toxin PF09907.9 AIC15931.1 - 5.3e-05 23.4 0.1 6.3e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system ParE_toxin PF05016.15 AIC15931.1 - 0.073 13.7 0.1 0.087 13.4 0.1 1.2 1 0 0 1 1 1 0 ParE toxin of type II toxin-antitoxin system, parDE SMC_N PF02463.19 AIC15933.1 - 1.2e-24 87.0 0.0 1.9e-11 43.8 0.0 2.3 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 AIC15933.1 - 8.6e-18 65.6 20.5 1.6e-15 58.2 20.5 3.3 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AIC15933.1 - 5e-13 49.5 0.2 1e-07 32.1 0.0 3.0 3 1 0 3 3 3 2 AAA ATPase domain AAA_21 PF13304.6 AIC15933.1 - 7.2e-13 49.0 0.1 6e-07 29.6 0.0 2.8 2 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AIC15933.1 - 1.2e-07 31.4 0.0 2.5e-07 30.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 AIC15933.1 - 1.6e-07 31.4 0.0 4.5e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_27 PF13514.6 AIC15933.1 - 4.4e-06 26.4 0.7 4.4e-06 26.4 0.7 3.1 2 1 1 3 3 3 1 AAA domain ABC_tran PF00005.27 AIC15933.1 - 2.5e-05 24.8 5.4 0.03 14.9 0.3 3.6 4 1 0 4 4 4 2 ABC transporter Lipoprotein_6 PF01441.19 AIC15933.1 - 0.015 15.3 2.2 3.3 7.7 0.7 2.6 2 0 0 2 2 2 0 Lipoprotein RsgA_GTPase PF03193.16 AIC15933.1 - 0.019 14.9 0.2 0.055 13.4 0.0 1.8 2 0 0 2 2 1 0 RsgA GTPase AAA_13 PF13166.6 AIC15933.1 - 0.065 11.9 20.7 0.094 11.3 0.0 4.3 3 1 2 5 5 5 0 AAA domain DNA_ligase_ZBD PF03119.16 AIC15933.1 - 0.09 12.8 0.0 0.36 10.9 0.0 2.1 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Vps39_2 PF10367.9 AIC15933.1 - 0.11 12.9 0.4 0.56 10.7 0.2 2.4 1 1 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 DUF5082 PF16888.5 AIC15933.1 - 0.54 10.5 21.6 0.39 11.0 2.4 4.5 4 1 1 5 5 5 0 Domain of unknown function (DUF5082) GTP_EFTU PF00009.27 AIC15933.1 - 0.82 9.2 3.4 2 7.9 0.0 2.7 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain DUF1664 PF07889.12 AIC15933.1 - 0.96 9.5 10.3 0.094 12.7 1.1 3.6 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) Dynamin_N PF00350.23 AIC15933.1 - 1 9.4 5.3 2.8 8.0 0.0 3.2 3 1 0 3 3 3 0 Dynamin family DUF4472 PF14739.6 AIC15933.1 - 3.6 8.4 18.6 0.51 11.1 8.4 3.2 3 1 0 3 3 2 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 AIC15933.1 - 3.6 8.1 34.3 0.23 12.0 14.3 3.7 3 1 2 5 5 2 0 Apg6 coiled-coil region Fzo_mitofusin PF04799.13 AIC15933.1 - 4.9 6.7 7.6 0.77 9.3 1.6 2.7 1 1 2 3 3 3 0 fzo-like conserved region zf-C4H2 PF10146.9 AIC15933.1 - 6.4 7.0 17.7 0.6 10.4 11.4 2.1 1 1 1 2 2 2 0 Zinc finger-containing protein Rx_N PF18052.1 AIC15933.1 - 6.7 7.1 11.5 71 3.8 3.7 3.9 2 1 1 3 3 3 0 Rx N-terminal domain Metallophos_2 PF12850.7 AIC15934.1 - 3.1e-12 47.0 0.1 5.3e-12 46.2 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 AIC15934.1 - 5.1e-11 43.5 0.2 7.9e-11 42.8 0.2 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ParE_toxin PF05016.15 AIC15935.1 - 8.8e-10 39.1 0.2 1e-09 38.9 0.2 1.0 1 0 0 1 1 1 1 ParE toxin of type II toxin-antitoxin system, parDE ParE-like_toxin PF15781.5 AIC15935.1 - 0.057 13.4 0.1 0.067 13.2 0.1 1.1 1 0 0 1 1 1 0 ParE-like toxin of type II bacterial toxin-antitoxin system Gp49 PF05973.14 AIC15935.1 - 0.075 13.2 0.1 0.098 12.8 0.1 1.2 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) DUF2710 PF10921.8 AIC15935.1 - 0.12 12.9 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2710) VAPB_antitox PF02697.14 AIC15936.1 - 0.00016 22.4 4.5 0.00039 21.1 4.5 1.8 1 1 0 1 1 1 1 Putative antitoxin MLD PF11647.8 AIC15936.1 - 0.042 14.1 0.2 0.15 12.4 0.1 1.8 1 1 1 2 2 2 0 Membrane Localization Domain SOCS PF12610.8 AIC15936.1 - 0.12 12.8 0.1 0.2 12.0 0.0 1.4 2 0 0 2 2 2 0 Suppressor of cytokine signalling DUF87 PF01935.17 AIC15938.1 - 1.6e-36 126.5 0.6 2.8e-36 125.7 0.3 1.6 2 0 0 2 2 2 1 Helicase HerA, central domain DUF853 PF05872.12 AIC15938.1 - 1.4e-05 23.9 0.1 0.013 14.1 0.0 2.2 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF853) HAS-barrel PF09378.10 AIC15938.1 - 0.0065 16.6 0.1 0.016 15.3 0.1 1.8 1 0 0 1 1 1 1 HAS barrel domain AAA_16 PF13191.6 AIC15938.1 - 0.025 15.0 0.1 0.093 13.1 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain AAA_10 PF12846.7 AIC15938.1 - 0.029 13.3 1.5 7 5.5 1.5 3.3 1 1 0 1 1 1 0 AAA-like domain FtsK_SpoIIIE PF01580.18 AIC15938.1 - 0.033 13.6 1.5 0.82 9.0 0.1 2.7 2 1 1 3 3 3 0 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 AIC15938.1 - 0.043 12.7 0.2 0.13 11.2 0.0 1.8 2 0 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain ABC_tran PF00005.27 AIC15938.1 - 0.16 12.4 0.0 0.49 10.9 0.0 1.7 1 1 0 1 1 1 0 ABC transporter NurA PF09376.10 AIC15939.1 - 2.8e-12 46.9 0.0 3.5e-12 46.5 0.0 1.1 1 0 0 1 1 1 1 NurA domain DAO PF01266.24 AIC15940.1 - 2.5e-45 155.6 0.1 3.3e-45 155.2 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Mqo PF06039.15 AIC15940.1 - 8.1e-10 37.9 0.0 1.2e-07 30.7 0.0 2.2 2 0 0 2 2 2 2 Malate:quinone oxidoreductase (Mqo) Pyr_redox_2 PF07992.14 AIC15940.1 - 0.00016 21.0 0.0 0.38 9.9 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AIC15940.1 - 0.0093 16.2 0.0 0.027 14.7 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 AIC15940.1 - 0.017 15.1 0.2 2.7 8.0 0.1 2.5 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 AIC15940.1 - 0.06 12.1 0.1 0.17 10.6 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Pyr_redox PF00070.27 AIC15940.1 - 0.18 12.4 0.0 1.9 9.1 0.1 2.4 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 AIC15940.1 - 0.2 10.9 0.0 0.34 10.1 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DNA_pol_B PF00136.21 AIC15941.1 - 8e-48 163.3 0.4 3.4e-47 161.2 0.4 1.9 1 1 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 AIC15941.1 - 3.8e-32 111.8 0.1 7.9e-32 110.7 0.1 1.5 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.9 AIC15941.1 - 0.00046 19.9 0.0 0.0012 18.5 0.0 1.7 1 0 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 AIC15941.1 - 0.0069 16.4 0.0 0.023 14.7 0.0 1.9 1 0 0 1 1 1 1 RNase_H superfamily DNA_pol_B_2 PF03175.13 AIC15941.1 - 0.018 13.9 0.0 0.21 10.4 0.0 2.3 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral TM1506 PF08973.10 AIC15941.1 - 0.11 12.1 0.0 0.26 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1893) Vinculin PF01044.19 AIC15941.1 - 0.17 10.1 0.0 0.25 9.5 0.0 1.1 1 0 0 1 1 1 0 Vinculin family Arginase PF00491.21 AIC15942.1 - 9.8e-55 186.0 0.0 1.1e-54 185.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family HigB_toxin PF09907.9 AIC15943.1 - 0.0011 19.2 0.5 0.0015 18.7 0.5 1.4 1 1 0 1 1 1 1 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system DUF104 PF01954.16 AIC15943.1 - 0.07 13.6 0.4 0.17 12.3 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF104 tRNA-Thr_ED PF08915.11 AIC15945.1 - 9.8e-43 145.5 0.7 2.1e-42 144.4 0.7 1.6 1 0 0 1 1 1 1 Archaea-specific editing domain of threonyl-tRNA synthetase HGTP_anticodon PF03129.20 AIC15945.1 - 1.9e-24 85.6 2.3 4.6e-24 84.4 2.3 1.7 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIC15945.1 - 3.7e-18 66.1 0.1 8.3e-18 65.0 0.1 1.6 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon2 PF12745.7 AIC15945.1 - 0.00018 21.1 0.7 0.00043 19.9 0.7 1.6 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs UPF0270 PF06794.12 AIC15945.1 - 0.21 11.7 0.9 2 8.5 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0270) COX16 PF14138.6 AIC15945.1 - 0.43 11.1 0.0 0.43 11.1 0.0 2.6 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 THAP PF05485.12 AIC15946.1 - 0.017 16.0 2.7 0.45 11.5 2.7 2.0 1 1 0 1 1 1 0 THAP domain YqaJ PF09588.10 AIC15946.1 - 0.035 14.3 0.1 0.04 14.1 0.1 1.1 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain DUF4367 PF14285.6 AIC15949.1 - 0.014 15.8 0.6 0.067 13.6 0.6 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4367) DUF3493 PF11998.8 AIC15949.1 - 0.088 13.0 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 Low psii accumulation1 / Rep27 DUF4239 PF14023.6 AIC15949.1 - 0.2 11.3 0.0 0.31 10.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) DUF4293 PF14126.6 AIC15950.1 - 0.17 12.1 0.1 0.36 11.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) DUF5491 PF17595.2 AIC15950.1 - 0.27 11.6 1.0 0.49 10.8 0.4 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5491) SSP160 PF06933.11 AIC15952.1 - 0.0022 16.3 8.3 0.0028 16.0 8.3 1.4 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 DUF4179 PF13786.6 AIC15952.1 - 0.032 14.7 0.6 0.067 13.7 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4179) Collagen PF01391.18 AIC15952.1 - 1.1 9.1 6.0 2.4 8.0 6.0 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) TM_helix PF05552.12 AIC15953.1 - 3.4e-16 58.9 15.6 1.5e-11 44.1 0.6 3.1 3 0 0 3 3 3 2 Conserved TM helix MS_channel PF00924.18 AIC15953.1 - 3.2e-10 39.9 3.1 3.2e-10 39.9 3.1 1.8 2 0 0 2 2 2 1 Mechanosensitive ion channel FtsX PF02687.21 AIC15953.1 - 0.75 10.3 23.8 0.13 12.8 2.0 3.4 1 1 1 3 3 3 0 FtsX-like permease family DUF543 PF04418.12 AIC15953.1 - 2.2 8.3 6.7 1.7 8.7 3.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF543) DZR PF12773.7 AIC15955.1 - 0.00062 19.7 0.9 0.00082 19.3 0.9 1.2 1 0 0 1 1 1 1 Double zinc ribbon zf-C3HC4_3 PF13920.6 AIC15955.1 - 0.001 18.9 0.7 0.0013 18.6 0.7 1.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) DHHC PF01529.20 AIC15955.1 - 0.0011 19.1 0.8 0.0013 18.8 0.8 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF1272 PF06906.11 AIC15955.1 - 0.0041 17.2 0.6 0.0045 17.0 0.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1272) Nudix_N_2 PF14803.6 AIC15955.1 - 0.011 15.6 2.7 0.44 10.5 0.3 2.1 2 0 0 2 2 2 0 Nudix N-terminal Cys_rich_KTR PF14205.6 AIC15955.1 - 0.011 15.5 1.3 0.04 13.7 0.3 1.9 2 0 0 2 2 2 0 Cysteine-rich KTR zf-ribbon_3 PF13248.6 AIC15955.1 - 0.012 15.0 1.6 0.12 11.8 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zf-NADH-PPase PF09297.11 AIC15955.1 - 0.017 14.7 2.3 1.9 8.3 0.2 2.2 2 0 0 2 2 2 0 NADH pyrophosphatase zinc ribbon domain zinc_ribbon_2 PF13240.6 AIC15955.1 - 0.026 14.2 4.3 0.33 10.7 0.3 2.0 1 1 2 3 3 3 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.12 AIC15955.1 - 0.056 13.7 6.1 0.13 12.5 0.5 2.1 1 1 1 2 2 2 0 Zinc-binding domain of primase-helicase zf-FPG_IleRS PF06827.14 AIC15955.1 - 0.058 13.3 4.2 1 9.3 0.4 2.1 2 0 0 2 2 2 0 Zinc finger found in FPG and IleRS SNase PF00565.17 AIC15956.1 - 0.12 12.8 0.0 0.14 12.6 0.0 1.1 1 0 0 1 1 1 0 Staphylococcal nuclease homologue DUF5519 PF17648.1 AIC15958.1 - 6.2e-31 106.7 0.0 6.7e-31 106.6 0.0 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5519) HTH_45 PF14947.6 AIC15959.1 - 1.3e-10 41.1 0.0 2.8e-10 40.0 0.0 1.5 1 1 0 1 1 1 1 Winged helix-turn-helix HTH_27 PF13463.6 AIC15959.1 - 0.0083 16.6 0.0 0.01 16.3 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain Mrr_N PF14338.6 AIC15959.1 - 0.019 15.1 0.0 0.032 14.4 0.0 1.3 1 1 0 1 1 1 0 Mrr N-terminal domain Amj PF10997.8 AIC15960.1 - 0.07 12.4 6.0 0.15 11.4 1.9 2.0 2 0 0 2 2 2 0 Alternate to MurJ IBR PF01485.21 AIC15961.1 - 0.00017 21.7 0.9 0.00024 21.2 0.9 1.3 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain zinc_ribbon_4 PF13717.6 AIC15961.1 - 0.00087 19.2 4.7 0.0091 15.9 4.7 2.0 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_6 PF14599.6 AIC15961.1 - 0.002 18.1 1.5 0.0028 17.6 1.5 1.2 1 0 0 1 1 1 1 Zinc-ribbon zinc_ribbon_5 PF13719.6 AIC15961.1 - 0.0084 15.9 4.4 0.018 14.8 4.4 1.5 1 1 0 1 1 1 1 zinc-ribbon domain Ribosomal_S27e PF01667.17 AIC15961.1 - 0.01 15.5 4.0 0.029 14.1 4.0 1.7 1 1 0 1 1 1 0 Ribosomal protein S27 zf-ACC PF17848.1 AIC15961.1 - 0.042 13.9 1.6 6.1 7.0 0.1 2.4 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain HypA PF01155.19 AIC15961.1 - 0.05 13.6 0.4 0.055 13.5 0.4 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ribbon_3 PF13248.6 AIC15961.1 - 0.078 12.4 2.8 0.92 9.0 2.8 2.1 1 1 0 1 1 1 0 zinc-ribbon domain Raf1_N PF18578.1 AIC15961.1 - 0.11 13.0 0.1 0.11 13.0 0.1 1.0 1 0 0 1 1 1 0 Rubisco accumulation factor 1 alpha helical domain PhnA_Zn_Ribbon PF08274.12 AIC15961.1 - 0.26 11.3 4.7 0.99 9.4 0.1 2.1 1 1 1 2 2 2 0 PhnA Zinc-Ribbon DZR PF12773.7 AIC15962.1 - 0.0043 17.0 1.3 0.0063 16.5 1.3 1.2 1 0 0 1 1 1 1 Double zinc ribbon Laminin_EGF PF00053.24 AIC15962.1 - 0.029 14.5 1.3 0.039 14.1 1.3 1.2 1 0 0 1 1 1 0 Laminin EGF domain HypA PF01155.19 AIC15962.1 - 0.05 13.6 0.2 0.068 13.2 0.2 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 AIC15962.1 - 0.17 12.0 2.4 0.7 10.1 2.4 1.9 1 1 0 1 1 1 0 Zinc ribbon domain Rubredoxin_2 PF18073.1 AIC15962.1 - 0.24 11.1 1.9 12 5.7 0.1 2.3 2 0 0 2 2 2 0 Rubredoxin metal binding domain Zn_ribbon_SprT PF17283.2 AIC15962.1 - 0.34 10.9 2.9 1.4 8.9 0.2 2.1 1 1 1 2 2 2 0 SprT-like zinc ribbon domain DUF35_N PF12172.8 AIC15962.1 - 4.8 7.2 5.7 2.1 8.3 1.1 2.1 1 1 1 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) Iron_traffic PF04362.14 AIC15963.1 - 6.6e-07 28.9 0.0 8.6e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Bacterial Fe(2+) trafficking zf_C2H2_13 PF18508.1 AIC15963.1 - 0.0093 15.5 0.8 0.99 9.0 0.5 2.2 2 0 0 2 2 2 2 Zinc finger domain Adenylsucc_synt PF00709.21 AIC15965.1 - 6.2e-83 279.0 0.4 2e-40 139.0 0.0 3.0 1 1 2 3 3 3 3 Adenylosuccinate synthetase OMPdecase PF00215.24 AIC15968.1 - 3.2e-29 102.1 0.8 3.9e-29 101.8 0.8 1.1 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family NUDIX PF00293.28 AIC15969.1 - 1.1e-16 61.0 0.2 1.3e-16 60.8 0.2 1.0 1 0 0 1 1 1 1 NUDIX domain Ribosomal_60s PF00428.19 AIC15970.1 - 1.8 9.2 8.6 2.1 9.0 8.6 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF373 PF04123.13 AIC15971.1 - 2.3e-92 310.0 9.3 2.9e-92 309.7 9.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF373) DUF4064 PF13273.6 AIC15971.1 - 4.5 7.6 17.9 0.094 13.0 8.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) HKR_ArcB_TM PF18415.1 AIC15971.1 - 4.9 8.0 7.5 0.5 11.2 2.1 2.2 2 0 0 2 2 2 0 Histidine kinase receptor ArcB trans-membrane domain FtsJ PF01728.19 AIC15972.1 - 1e-58 198.3 0.0 1.2e-58 198.1 0.0 1.0 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 AIC15972.1 - 6e-07 29.4 0.1 1.1e-05 25.3 0.1 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC15972.1 - 1.9e-05 24.6 0.0 0.00012 21.9 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC15972.1 - 0.00032 21.3 0.4 0.0062 17.2 0.3 2.4 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC15972.1 - 0.012 16.4 0.0 0.055 14.2 0.0 2.1 1 1 1 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 AIC15972.1 - 0.044 14.4 0.4 0.2 12.3 0.2 2.3 2 1 0 2 2 2 0 Methyltransferase domain Ubie_methyltran PF01209.18 AIC15972.1 - 0.049 13.0 0.1 0.23 10.8 0.1 2.0 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family CMAS PF02353.20 AIC15972.1 - 0.17 11.1 0.0 0.26 10.6 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase RNA_pol_Rpc34 PF05158.12 AIC15973.1 - 0.00083 18.8 0.1 0.00083 18.8 0.1 2.2 2 1 1 3 3 3 1 RNA polymerase Rpc34 subunit MarR PF01047.22 AIC15973.1 - 0.019 14.9 0.1 0.035 14.0 0.1 1.4 1 0 0 1 1 1 0 MarR family B-block_TFIIIC PF04182.12 AIC15973.1 - 0.073 13.2 0.0 0.09 12.9 0.0 1.4 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC Glyoxalase_6 PF18029.1 AIC15974.1 - 9.3e-06 26.4 0.0 1.9e-05 25.4 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 AIC15974.1 - 1.4e-05 25.3 0.0 0.00018 21.7 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HpaB_N PF11794.8 AIC15975.1 - 2.7e-94 315.8 0.0 5.6e-94 314.8 0.0 1.5 2 0 0 2 2 2 1 4-hydroxyphenylacetate 3-hydroxylase N terminal HpaB PF03241.13 AIC15975.1 - 6.4e-75 250.7 0.3 8.8e-75 250.2 0.3 1.2 1 0 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase C terminal zf-Tim10_DDP PF02953.15 AIC15975.1 - 0.13 11.9 0.0 0.31 10.7 0.0 1.6 1 0 0 1 1 1 0 Tim10/DDP family zinc finger Acyl-CoA_dh_M PF02770.19 AIC15975.1 - 0.14 12.4 0.0 0.39 10.9 0.0 1.7 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Abhydrolase_1 PF00561.20 AIC15976.1 - 2.4e-20 73.3 0.5 7.4e-19 68.4 0.5 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIC15976.1 - 3.9e-18 66.9 0.0 4.6e-18 66.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIC15976.1 - 5.1e-18 65.2 0.0 1.3e-17 63.9 0.0 1.6 1 1 0 1 1 1 1 Serine aminopeptidase, S33 DUF1057 PF06342.12 AIC15976.1 - 1.7e-05 24.0 0.0 3.7e-05 22.9 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) DUF676 PF05057.14 AIC15976.1 - 0.00027 20.5 0.0 0.00078 19.0 0.0 1.8 2 1 0 2 2 2 1 Putative serine esterase (DUF676) Abhydrolase_2 PF02230.16 AIC15976.1 - 0.00034 20.5 0.2 0.46 10.3 0.1 3.1 3 0 0 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_5 PF12695.7 AIC15976.1 - 0.00035 20.4 0.1 0.055 13.2 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase family Thioesterase PF00975.20 AIC15976.1 - 0.00042 20.5 0.0 0.00052 20.2 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain UPF0227 PF05728.12 AIC15976.1 - 0.00053 20.0 0.1 0.0022 18.0 0.1 2.1 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0227) Chlorophyllase2 PF12740.7 AIC15976.1 - 0.00067 18.6 0.0 0.00099 18.1 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme PGAP1 PF07819.13 AIC15976.1 - 0.0013 18.5 0.4 0.25 11.0 0.3 2.7 1 1 2 3 3 3 1 PGAP1-like protein Peptidase_S9 PF00326.21 AIC15976.1 - 0.01 15.4 0.0 0.061 12.8 0.0 2.0 2 0 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 AIC15976.1 - 0.011 15.5 0.0 0.21 11.2 0.0 2.6 2 1 0 2 2 2 0 Serine hydrolase (FSH1) LIDHydrolase PF10230.9 AIC15976.1 - 0.012 15.1 0.0 0.015 14.9 0.0 1.3 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase Ndr PF03096.14 AIC15976.1 - 0.015 14.1 0.0 0.026 13.2 0.0 1.5 1 1 0 1 1 1 0 Ndr family Abhydro_lipase PF04083.16 AIC15976.1 - 0.021 14.4 0.1 0.074 12.6 0.1 1.8 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region Esterase PF00756.20 AIC15976.1 - 0.027 14.1 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative esterase Ser_hydrolase PF06821.13 AIC15976.1 - 0.03 14.2 0.0 0.078 12.8 0.0 1.7 2 0 0 2 2 2 0 Serine hydrolase Abhydrolase_3 PF07859.13 AIC15976.1 - 0.039 13.8 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Chlorophyllase PF07224.11 AIC15976.1 - 0.052 12.5 0.0 0.07 12.1 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase Lipase_3 PF01764.25 AIC15976.1 - 0.071 13.0 0.0 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Lipase (class 3) Abhydrolase_8 PF06259.12 AIC15976.1 - 0.11 12.1 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase Peptidase_M10 PF00413.24 AIC15977.1 - 0.086 12.7 0.3 0.13 12.1 0.3 1.4 1 1 0 1 1 1 0 Matrixin OrfB_Zn_ribbon PF07282.11 AIC15978.1 - 1.9e-18 66.1 0.3 3.5e-18 65.3 0.3 1.5 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zf_UBZ PF18439.1 AIC15978.1 - 0.0092 15.6 1.4 0.13 11.8 0.1 2.4 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIC15978.1 - 0.013 15.6 0.4 0.029 14.4 0.4 1.5 1 0 0 1 1 1 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 AIC15978.1 - 0.016 15.1 3.6 0.038 14.0 3.6 1.5 1 0 0 1 1 1 0 Transposase zinc-ribbon domain RTC4 PF14474.6 AIC15978.1 - 0.028 14.6 0.1 0.048 13.8 0.1 1.3 1 0 0 1 1 1 0 RTC4-like domain zf-CCHC_5 PF14787.6 AIC15978.1 - 0.1 12.3 0.6 0.1 12.3 0.6 1.7 2 0 0 2 2 2 0 GAG-polyprotein viral zinc-finger OrfB_IS605 PF01385.19 AIC15978.1 - 1.3 9.3 6.1 0.61 10.3 3.1 1.9 1 1 1 2 2 2 0 Probable transposase Arm-DNA-bind_4 PF14657.6 AIC15979.1 - 0.051 13.3 0.5 1.5 8.7 0.4 2.3 2 0 0 2 2 2 0 Arm DNA-binding domain Pribosyltran PF00156.27 AIC15980.1 - 3.8e-12 46.0 0.1 5e-12 45.6 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIC15980.1 - 5e-05 22.8 0.0 6.6e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 AIC15980.1 - 0.089 12.3 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribosyl transferase PNP_UDP_1 PF01048.20 AIC15981.1 - 1.2e-44 152.3 0.0 1.4e-44 152.1 0.0 1.0 1 0 0 1 1 1 1 Phosphorylase superfamily TrmB PF01978.19 AIC15984.1 - 1.1e-10 41.2 0.1 1.4e-10 40.9 0.1 1.2 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Ferritin PF00210.24 AIC15985.1 - 4.4e-25 88.3 0.2 5.1e-25 88.1 0.2 1.0 1 0 0 1 1 1 1 Ferritin-like domain PspA_IM30 PF04012.12 AIC15985.1 - 0.039 13.5 0.4 0.067 12.8 0.4 1.3 1 0 0 1 1 1 0 PspA/IM30 family Rubrerythrin PF02915.17 AIC15985.1 - 0.042 14.2 0.3 1.1 9.7 0.2 2.1 1 1 1 2 2 2 0 Rubrerythrin Ferritin_2 PF13668.6 AIC15985.1 - 0.057 13.6 0.1 0.082 13.1 0.1 1.3 1 0 0 1 1 1 0 Ferritin-like domain PfkB PF00294.24 AIC15988.1 - 6.8e-25 88.0 0.0 1e-24 87.4 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Flavoprotein PF02441.19 AIC15989.1 - 2.3e-27 95.7 0.0 3.3e-27 95.2 0.0 1.2 1 0 0 1 1 1 1 Flavoprotein CofC PF01983.16 AIC15989.1 - 0.096 11.9 0.0 0.22 10.7 0.0 1.5 2 0 0 2 2 2 0 Guanylyl transferase CofC like ArsA_HSP20 PF17886.1 AIC15990.1 - 8e-05 22.1 0.0 0.00023 20.6 0.0 1.8 2 0 0 2 2 2 1 HSP20-like domain found in ArsA GvpH PF05455.11 AIC15990.1 - 0.0011 19.1 0.0 0.0013 18.8 0.0 1.1 1 0 0 1 1 1 1 GvpH HSP20 PF00011.21 AIC15990.1 - 0.076 13.2 0.1 2.9 8.1 0.0 2.5 2 1 0 2 2 2 0 Hsp20/alpha crystallin family Cas_Cas4 PF01930.17 AIC15991.1 - 3.7e-15 56.4 0.1 4.4e-15 56.2 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 AIC15991.1 - 0.00013 22.0 0.1 0.00015 21.8 0.1 1.1 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Exo5 PF09810.9 AIC15991.1 - 0.19 11.2 1.1 0.4 10.1 0.0 2.0 2 1 0 2 2 2 0 Exonuclease V - a 5' deoxyribonuclease CRISPR_Cas2 PF09827.9 AIC15992.1 - 3.5e-13 49.5 1.2 4.1e-13 49.3 1.2 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas2 YcxB PF14317.6 AIC15992.1 - 0.0079 15.9 0.3 0.02 14.6 0.0 1.8 2 1 0 2 2 2 1 YcxB-like protein DUF1955 PF09205.10 AIC15992.1 - 0.029 14.1 0.1 0.035 13.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) Cas_Cas1 PF01867.16 AIC15993.1 - 1.5e-73 247.4 0.0 1.7e-73 247.2 0.0 1.0 1 0 0 1 1 1 1 CRISPR associated protein Cas1 Cas6b_C PF17262.2 AIC15994.1 - 4.3e-37 126.7 0.2 6e-37 126.2 0.2 1.2 1 0 0 1 1 1 1 Cas6b C-terminal domain Cas6b_N PF17955.1 AIC15994.1 - 1.1e-13 51.1 0.0 2.4e-13 50.0 0.0 1.6 2 0 0 2 2 2 1 Cas6b N-terminal domain DEAD PF00270.29 AIC15995.1 - 4.5e-14 52.6 0.3 1.5e-11 44.3 0.0 2.7 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 AIC15995.1 - 3e-09 37.1 0.0 4.5e-08 33.3 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit HD_6 PF18019.1 AIC15995.1 - 1e-07 32.3 0.3 2.1e-07 31.3 0.3 1.5 1 0 0 1 1 1 1 HD domain HD PF01966.22 AIC15995.1 - 3.4e-06 27.3 0.1 9e-06 25.9 0.1 1.7 1 0 0 1 1 1 1 HD domain Helicase_C PF00271.31 AIC15995.1 - 7.4e-06 26.3 0.1 3.4e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDOD PF08668.12 AIC15995.1 - 8.7e-06 25.3 0.0 1.7e-05 24.4 0.0 1.4 1 0 0 1 1 1 1 HDOD domain AAA_22 PF13401.6 AIC15995.1 - 0.001 19.4 0.1 0.0094 16.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 AIC15995.1 - 0.002 18.5 0.0 0.015 15.6 0.0 2.3 2 1 0 2 2 2 1 AAA domain TetR_C_3 PF08362.11 AIC15995.1 - 0.0033 17.4 0.0 0.011 15.7 0.0 1.8 2 0 0 2 2 2 1 YcdC-like protein, C-terminal region DnaB_C PF03796.15 AIC15995.1 - 0.099 12.0 0.0 0.18 11.1 0.0 1.4 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain Cas_Cas5d PF09704.10 AIC15996.1 - 4.7e-11 43.0 0.0 6.9e-11 42.4 0.0 1.2 1 1 0 1 1 1 1 CRISPR-associated protein (Cas_Cas5) BRCT PF00533.26 AIC15996.1 - 0.15 12.5 0.0 0.27 11.6 0.0 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Cas_Cas7 PF05107.12 AIC15997.1 - 2.8e-35 122.1 0.1 3.7e-35 121.7 0.1 1.1 1 0 0 1 1 1 1 CRISPR-associated protein Cas7 DUF2527 PF10736.9 AIC15998.1 - 0.025 14.4 0.2 0.081 12.8 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2627) KH_1 PF00013.29 AIC15999.1 - 6.2e-13 48.4 3.7 1.6e-06 27.8 0.8 2.4 2 0 0 2 2 2 2 KH domain KH_2 PF07650.17 AIC15999.1 - 0.00019 21.2 2.2 0.4 10.5 0.1 2.4 2 0 0 2 2 2 2 KH domain KH_8 PF17903.1 AIC15999.1 - 0.042 13.9 0.0 0.22 11.6 0.0 2.0 2 0 0 2 2 2 0 Krr1 KH1 domain RIO1 PF01163.22 AIC16000.1 - 7e-56 188.8 1.8 1.6e-55 187.6 0.0 1.9 2 0 0 2 2 2 1 RIO1 family Pkinase PF00069.25 AIC16000.1 - 9.9e-06 25.1 0.0 2.4e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 AIC16000.1 - 5.4e-05 22.6 0.0 0.00063 19.2 0.0 2.2 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 AIC16000.1 - 0.00012 22.1 1.3 0.38 10.6 0.0 3.2 2 1 1 3 3 3 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 AIC16000.1 - 0.00018 20.5 0.1 0.00031 19.6 0.1 1.4 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 AIC16000.1 - 0.027 13.8 0.3 0.29 10.4 0.0 2.2 2 0 0 2 2 2 0 Kinase-like DUF424 PF04242.13 AIC16001.1 - 5.7e-15 55.4 0.0 6.3e-15 55.2 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF424) NAD_binding_1 PF00175.21 AIC16002.1 - 3.6e-12 46.9 0.0 6e-12 46.2 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 AIC16002.1 - 1.8e-10 41.1 0.0 3e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 AIC16002.1 - 0.17 12.0 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Ferric reductase NAD binding domain T4SS PF07996.11 AIC16003.1 - 0.13 12.6 0.3 17 5.7 0.0 2.1 1 1 1 2 2 2 0 Type IV secretion system proteins TRM PF02005.16 AIC16004.1 - 2.1e-92 310.2 0.0 2.6e-92 309.9 0.0 1.0 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Met_10 PF02475.16 AIC16004.1 - 0.00025 20.9 0.0 0.00069 19.4 0.0 1.8 2 0 0 2 2 2 1 Met-10+ like-protein TackOD1 PF18551.1 AIC16004.1 - 0.0021 17.8 0.3 0.004 16.8 0.3 1.4 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 MTS PF05175.14 AIC16004.1 - 0.0036 16.9 0.0 0.0086 15.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase small domain zf-C3HC4_3 PF13920.6 AIC16004.1 - 0.0054 16.6 0.5 0.013 15.4 0.5 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PrmA PF06325.13 AIC16004.1 - 0.0073 15.7 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_31 PF13847.6 AIC16004.1 - 0.0074 16.1 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain DUF4023 PF13215.6 AIC16004.1 - 0.0086 16.1 0.9 0.024 14.6 0.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4023) Methyltransf_3 PF01596.17 AIC16004.1 - 0.041 13.0 0.0 0.073 12.2 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_25 PF13649.6 AIC16004.1 - 0.044 14.5 0.0 0.11 13.2 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain HypA PF01155.19 AIC16004.1 - 0.11 12.5 0.2 0.31 11.1 0.1 1.8 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF2175 PF09943.9 AIC16004.1 - 0.13 12.6 0.0 1.3 9.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) PALP PF00291.25 AIC16006.1 - 4.6e-22 78.8 0.4 2e-20 73.4 0.1 3.1 2 1 0 2 2 2 1 Pyridoxal-phosphate dependent enzyme RNase_HII PF01351.18 AIC16007.1 - 3.8e-45 154.2 0.5 4.5e-45 153.9 0.5 1.0 1 0 0 1 1 1 1 Ribonuclease HII DUF1672 PF07901.11 AIC16007.1 - 0.099 12.0 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Fibrillarin PF01269.17 AIC16008.1 - 4.2e-86 287.7 0.0 4.9e-86 287.5 0.0 1.0 1 0 0 1 1 1 1 Fibrillarin Methyltransf_25 PF13649.6 AIC16008.1 - 7.9e-05 23.3 0.0 0.00044 20.9 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 AIC16008.1 - 0.0002 21.2 0.2 0.00028 20.7 0.2 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltr_RsmB-F PF01189.17 AIC16008.1 - 0.0086 15.7 0.0 0.022 14.4 0.0 1.6 1 1 0 1 1 1 1 16S rRNA methyltransferase RsmB/F GCD14 PF08704.10 AIC16008.1 - 0.013 15.2 0.0 0.019 14.7 0.0 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_23 PF13489.6 AIC16008.1 - 0.2 11.5 0.0 0.32 10.8 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Nop PF01798.18 AIC16009.1 - 2.3e-64 217.0 0.4 3.4e-64 216.4 0.4 1.3 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Peptidase_S24 PF00717.23 AIC16011.1 - 2.1e-09 37.2 0.7 4.5e-09 36.1 0.7 1.7 1 1 0 1 1 1 1 Peptidase S24-like BAH PF01426.18 AIC16011.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 BAH domain TrbC PF04956.13 AIC16011.1 - 0.26 11.5 3.6 2 8.7 0.1 2.2 2 0 0 2 2 2 0 TrbC/VIRB2 family UPF0047 PF01894.17 AIC16012.1 - 6.6e-37 126.2 0.0 7.8e-37 125.9 0.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0047 TBP PF00352.21 AIC16013.1 - 9.2e-54 179.4 0.1 9.1e-27 92.8 0.1 2.0 2 0 0 2 2 2 2 Transcription factor TFIID (or TATA-binding protein, TBP) DUF3378 PF11858.8 AIC16013.1 - 5.9e-07 29.5 0.0 0.014 15.5 0.1 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF3378) TPM_phosphatase PF04536.14 AIC16014.1 - 2.4e-16 60.0 0.1 4.7e-16 59.1 0.1 1.5 1 1 0 1 1 1 1 TPM domain Peripla_BP_4 PF13407.6 AIC16014.1 - 0.14 11.7 1.2 0.25 10.9 1.2 1.3 1 0 0 1 1 1 0 Periplasmic binding protein domain LemA PF04011.12 AIC16015.1 - 6.8e-46 155.8 1.0 9e-46 155.4 1.0 1.2 1 0 0 1 1 1 1 LemA family DUF945 PF06097.11 AIC16015.1 - 0.14 11.3 1.7 0.4 9.7 0.4 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF945) Pribosyltran PF00156.27 AIC16016.1 - 7.9e-16 58.0 0.6 1.2e-15 57.4 0.6 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 AIC16016.1 - 0.0015 18.1 0.1 0.002 17.6 0.1 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 AIC16016.1 - 0.0048 16.4 0.1 0.0079 15.7 0.1 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase Peptidase_M50 PF02163.22 AIC16018.1 - 1.1e-14 54.3 9.9 7e-09 35.3 0.2 2.4 1 1 1 2 2 2 2 Peptidase family M50 Acetyltransf_1 PF00583.25 AIC16019.1 - 4.5e-19 68.8 0.1 6e-19 68.4 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIC16019.1 - 5.1e-12 46.0 0.2 8e-12 45.4 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIC16019.1 - 5.6e-11 42.5 0.2 8.5e-11 41.9 0.2 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIC16019.1 - 1e-09 38.2 0.2 2.1e-09 37.2 0.2 1.5 1 1 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 AIC16019.1 - 4.5e-06 26.8 0.0 9.5e-06 25.7 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 AIC16019.1 - 0.00073 19.2 0.0 0.0017 18.1 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 AIC16019.1 - 0.062 14.0 0.0 0.09 13.4 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain 4HB_MCP_1 PF12729.7 AIC16020.1 - 8.9e-08 31.9 5.7 7.9e-07 28.8 1.4 2.5 3 0 0 3 3 3 2 Four helix bundle sensory module for signal transduction DUF835 PF05763.12 AIC16020.1 - 0.005 16.6 0.0 0.0096 15.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF835) Dodecin PF07311.12 AIC16021.1 - 3e-21 75.4 3.5 3.3e-21 75.3 3.5 1.0 1 0 0 1 1 1 1 Dodecin HisKA_7TM PF16927.5 AIC16022.1 - 0.0074 16.4 2.3 0.0076 16.3 2.3 1.0 1 0 0 1 1 1 1 N-terminal 7TM region of histidine kinase Phage_holin_3_6 PF07332.11 AIC16022.1 - 0.034 14.2 6.5 0.039 14.0 6.5 1.0 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2157 PF09925.9 AIC16022.1 - 0.046 13.5 2.6 0.056 13.2 2.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) Myc_target_1 PF15179.6 AIC16022.1 - 0.19 11.6 0.1 0.21 11.4 0.1 1.1 1 0 0 1 1 1 0 Myc target protein 1 DUF4307 PF14155.6 AIC16022.1 - 1.8 8.4 6.6 4 7.3 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) Met_10 PF02475.16 AIC16023.1 - 9.1e-62 208.3 0.8 1.2e-61 207.9 0.8 1.2 1 0 0 1 1 1 1 Met-10+ like-protein Methyltransf_15 PF09445.10 AIC16023.1 - 2.6e-07 30.4 0.0 4.3e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase PrmA PF06325.13 AIC16023.1 - 0.00037 20.0 1.1 0.00043 19.8 0.2 1.5 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) MTS PF05175.14 AIC16023.1 - 0.0073 15.9 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain DUF4893 PF16233.5 AIC16023.1 - 0.029 13.9 0.0 0.11 12.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4893) TRM PF02005.16 AIC16023.1 - 0.034 13.3 0.1 0.033 13.3 0.1 1.3 1 0 0 1 1 1 0 N2,N2-dimethylguanosine tRNA methyltransferase Methyltrans_SAM PF10672.9 AIC16023.1 - 0.036 13.2 0.0 0.052 12.7 0.0 1.3 1 0 0 1 1 1 0 S-adenosylmethionine-dependent methyltransferase Methyltransf_25 PF13649.6 AIC16023.1 - 0.08 13.7 0.0 0.18 12.6 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain ABC_tran PF00005.27 AIC16024.1 - 8.3e-38 130.0 0.0 1e-17 64.9 0.0 2.5 2 0 0 2 2 2 2 ABC transporter SMC_N PF02463.19 AIC16024.1 - 1.6e-11 44.1 0.9 0.0002 20.8 0.3 3.2 2 2 0 2 2 2 2 RecF/RecN/SMC N terminal domain RLI PF04068.15 AIC16024.1 - 9.8e-10 38.1 1.3 2.4e-09 36.9 1.3 1.7 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI AAA_21 PF13304.6 AIC16024.1 - 1.7e-08 34.7 3.4 0.17 11.7 0.0 4.3 2 2 2 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system Fer4 PF00037.27 AIC16024.1 - 9.5e-08 31.6 3.3 9.5e-08 31.6 3.3 2.5 2 0 0 2 2 2 1 4Fe-4S binding domain Fer4_6 PF12837.7 AIC16024.1 - 6.8e-06 25.9 12.6 9e-05 22.4 1.7 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_21 PF14697.6 AIC16024.1 - 0.00014 21.9 10.3 0.00023 21.2 10.3 1.3 1 0 0 1 1 1 1 4Fe-4S dicluster domain MMR_HSR1 PF01926.23 AIC16024.1 - 0.00015 21.8 1.1 0.06 13.4 0.2 2.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 AIC16024.1 - 0.00035 21.0 0.3 1.4 9.3 0.2 2.6 2 1 0 2 2 2 2 AAA ATPase domain Fer4_7 PF12838.7 AIC16024.1 - 0.00055 20.5 8.7 0.0011 19.5 8.7 1.6 1 0 0 1 1 1 1 4Fe-4S dicluster domain AAA_15 PF13175.6 AIC16024.1 - 0.00088 19.1 0.0 0.44 10.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain SbcCD_C PF13558.6 AIC16024.1 - 0.0011 19.2 0.1 2.7 8.3 0.1 2.6 2 1 0 2 2 2 2 Putative exonuclease SbcCD, C subunit RsgA_GTPase PF03193.16 AIC16024.1 - 0.0012 18.7 1.2 0.014 15.4 0.0 2.6 3 0 0 3 3 3 1 RsgA GTPase Fer4_10 PF13237.6 AIC16024.1 - 0.0013 18.8 1.3 0.0013 18.8 1.3 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIC16024.1 - 0.0018 18.3 0.7 0.0018 18.3 0.7 2.4 2 0 0 2 2 2 1 4Fe-4S binding domain AAA_29 PF13555.6 AIC16024.1 - 0.0027 17.4 0.1 0.087 12.6 0.0 2.5 2 0 0 2 2 2 1 P-loop containing region of AAA domain Fer4_16 PF13484.6 AIC16024.1 - 0.0083 17.0 6.5 0.01 16.8 0.1 2.5 2 0 0 2 2 2 1 4Fe-4S double cluster binding domain NB-ARC PF00931.22 AIC16024.1 - 0.0098 15.1 0.1 0.15 11.2 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_23 PF13476.6 AIC16024.1 - 0.01 16.3 0.0 0.74 10.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain Fer4_9 PF13187.6 AIC16024.1 - 0.013 15.6 10.5 0.027 14.6 10.5 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain AAA_25 PF13481.6 AIC16024.1 - 0.016 14.8 0.2 8.1 6.0 0.0 2.5 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 AIC16024.1 - 0.05 12.9 0.0 10 5.3 0.0 2.2 2 0 0 2 2 2 0 Septin FeoB_N PF02421.18 AIC16024.1 - 0.066 12.7 0.6 1.6 8.2 0.1 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 AIC16024.1 - 0.087 12.6 0.4 6.7 6.4 0.0 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 AIC16024.1 - 0.11 12.6 0.5 12 5.9 0.0 3.4 4 0 0 4 4 3 0 AAA domain AAA_28 PF13521.6 AIC16024.1 - 0.14 12.3 0.3 78 3.5 0.0 3.4 4 0 0 4 4 3 0 AAA domain AAA_33 PF13671.6 AIC16024.1 - 0.16 12.1 0.4 19 5.4 0.0 2.9 3 0 0 3 3 2 0 AAA domain KAP_NTPase PF07693.14 AIC16024.1 - 0.21 10.8 0.0 0.29 10.3 0.0 1.4 1 0 0 1 1 1 0 KAP family P-loop domain Dynamin_N PF00350.23 AIC16024.1 - 0.44 10.6 2.1 16 5.5 0.3 2.5 2 0 0 2 2 2 0 Dynamin family MeaB PF03308.16 AIC16024.1 - 0.68 8.9 2.2 1.6 7.7 0.3 2.2 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Fer4_4 PF12800.7 AIC16024.1 - 2.3 8.9 12.4 0.58 10.8 2.7 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_3 PF12798.7 AIC16024.1 - 4.3 8.5 14.7 0.6 11.2 3.0 2.3 2 0 0 2 2 2 0 4Fe-4S binding domain Fer4_17 PF13534.6 AIC16024.1 - 6.2 7.4 8.9 0.38 11.3 1.5 2.2 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIC16024.1 - 6.5 7.3 8.2 1.1 9.8 1.5 1.9 1 1 1 2 2 2 0 4Fe-4S dicluster domain HTH_24 PF13412.6 AIC16027.1 - 4.5e-07 29.3 0.0 1.2e-06 28.0 0.0 1.7 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_5 PF01022.20 AIC16027.1 - 3.8e-05 23.4 0.0 8.7e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_AsnC-type PF13404.6 AIC16027.1 - 4.4e-05 23.2 0.0 0.00027 20.7 0.0 2.2 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain HMA PF00403.26 AIC16027.1 - 0.0003 21.2 0.7 0.00069 20.0 0.7 1.6 1 0 0 1 1 1 1 Heavy-metal-associated domain HTH_9 PF08221.11 AIC16027.1 - 0.0067 16.5 0.0 0.019 15.1 0.0 1.7 1 0 0 1 1 1 1 RNA polymerase III subunit RPC82 helix-turn-helix domain HTH_20 PF12840.7 AIC16027.1 - 0.015 15.4 0.0 0.051 13.6 0.0 1.9 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Mga PF08280.11 AIC16027.1 - 0.026 14.6 0.0 0.076 13.1 0.0 1.8 1 1 0 1 1 1 0 M protein trans-acting positive regulator (MGA) HTH domain MarR_2 PF12802.7 AIC16027.1 - 0.035 14.0 0.0 0.065 13.1 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_11 PF08279.12 AIC16027.1 - 0.057 13.4 0.1 0.23 11.4 0.0 2.0 2 0 0 2 2 2 0 HTH domain HTH_IclR PF09339.10 AIC16027.1 - 0.075 12.9 0.0 0.19 11.6 0.0 1.6 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_29 PF13551.6 AIC16027.1 - 0.099 12.7 0.1 0.77 9.8 0.0 2.3 3 0 0 3 3 3 0 Winged helix-turn helix Peptidase_M17 PF00883.21 AIC16029.1 - 5.9e-122 406.8 0.1 7.4e-122 406.5 0.1 1.1 1 0 0 1 1 1 1 Cytosol aminopeptidase family, catalytic domain Peptidase_M17_N PF02789.17 AIC16029.1 - 3.2e-21 75.5 0.1 1e-20 73.9 0.0 1.9 2 0 0 2 2 2 1 Cytosol aminopeptidase family, N-terminal domain DUF1294 PF06961.13 AIC16029.1 - 0.015 15.5 0.0 0.035 14.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) Med25_VWA PF11265.8 AIC16029.1 - 0.019 14.8 0.0 0.039 13.8 0.0 1.4 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A FYRN PF05964.14 AIC16030.1 - 0.0023 17.7 0.0 0.0045 16.8 0.0 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus Ribul_P_3_epim PF00834.19 AIC16031.1 - 4.5e-58 195.9 0.1 6.5e-58 195.4 0.1 1.2 1 0 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Transketolase_N PF00456.21 AIC16031.1 - 2.3e-50 171.4 0.0 4.2e-50 170.6 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.6 AIC16031.1 - 9.3e-08 31.6 0.1 0.00017 20.9 0.2 2.9 2 1 1 3 3 3 2 1-deoxy-D-xylulose-5-phosphate synthase E1_dh PF00676.20 AIC16031.1 - 1.3e-07 30.8 0.1 2.9e-07 29.8 0.0 1.5 1 1 0 1 1 1 1 Dehydrogenase E1 component TPP_enzyme_C PF02775.21 AIC16031.1 - 0.00035 20.4 0.2 0.0045 16.8 0.2 2.4 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Radical_SAM PF04055.21 AIC16031.1 - 0.019 15.3 0.2 3.3 8.1 0.1 3.2 3 1 0 3 3 3 0 Radical SAM superfamily Transket_pyr PF02779.24 AIC16032.1 - 6e-34 117.3 0.0 9e-34 116.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_C PF02780.20 AIC16032.1 - 1.4e-32 112.2 0.3 2.6e-32 111.3 0.3 1.5 1 0 0 1 1 1 1 Transketolase, C-terminal domain PFOR_II PF17147.4 AIC16032.1 - 0.051 13.9 0.1 0.15 12.4 0.1 1.9 1 1 0 1 1 1 0 Pyruvate:ferredoxin oxidoreductase core domain II TAL_FSA PF00923.19 AIC16033.1 - 5.7e-60 203.1 0.2 8.6e-59 199.2 0.2 2.1 1 1 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase VWA PF00092.28 AIC16034.1 - 3e-05 24.3 0.1 0.00031 21.0 0.1 2.3 1 1 0 1 1 1 1 von Willebrand factor type A domain AAA_5 PF07728.14 AIC16035.1 - 1.8e-28 99.2 0.0 2.7e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 AIC16035.1 - 5.3e-12 45.7 0.0 7.3e-12 45.3 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 AIC16035.1 - 1.9e-07 31.6 0.0 3.4e-07 30.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AIC16035.1 - 1.4e-06 28.8 0.1 3.7e-06 27.4 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 AIC16035.1 - 1.7e-06 27.7 0.0 2.8e-06 26.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 AIC16035.1 - 2.3e-05 24.4 0.0 4e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 AIC16035.1 - 4.5e-05 23.5 0.0 6.5e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_30 PF13604.6 AIC16035.1 - 0.00014 21.6 0.4 0.00058 19.6 0.4 2.0 1 1 0 1 1 1 1 AAA domain MCM PF00493.23 AIC16035.1 - 0.00018 20.7 0.0 0.0004 19.5 0.0 1.5 1 1 0 1 1 1 1 MCM P-loop domain AAA_22 PF13401.6 AIC16035.1 - 0.0002 21.6 0.2 0.00043 20.6 0.2 1.6 1 1 0 1 1 1 1 AAA domain AAA_6 PF12774.7 AIC16035.1 - 0.00025 20.2 0.0 0.0012 17.9 0.0 1.9 1 1 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_11 PF13086.6 AIC16035.1 - 0.00027 20.8 0.0 0.00039 20.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain KAP_NTPase PF07693.14 AIC16035.1 - 0.00048 19.5 0.0 0.00067 19.0 0.0 1.1 1 0 0 1 1 1 1 KAP family P-loop domain NACHT PF05729.12 AIC16035.1 - 0.00049 20.1 0.0 0.00084 19.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Mg_chelatase PF01078.21 AIC16035.1 - 0.00079 18.9 0.2 0.53 9.6 0.1 2.2 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 AIC16035.1 - 0.00092 19.0 0.1 0.0029 17.3 0.1 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain SRP54 PF00448.22 AIC16035.1 - 0.0014 18.3 0.1 0.0028 17.3 0.1 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain RuvB_N PF05496.12 AIC16035.1 - 0.0015 18.3 0.1 0.0064 16.2 0.1 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 AIC16035.1 - 0.0035 17.6 0.1 0.011 16.0 0.0 1.9 2 0 0 2 2 1 1 AAA domain TsaE PF02367.17 AIC16035.1 - 0.0039 17.2 0.0 0.0082 16.1 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 AIC16035.1 - 0.0054 17.2 0.1 0.017 15.6 0.1 1.6 1 1 0 1 1 1 1 ABC transporter Sigma54_activ_2 PF14532.6 AIC16035.1 - 0.0066 16.6 0.0 0.015 15.4 0.0 1.6 1 1 0 1 1 1 1 Sigma-54 interaction domain Roc PF08477.13 AIC16035.1 - 0.0075 16.5 0.1 0.022 15.0 0.1 1.7 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 AIC16035.1 - 0.0079 16.4 0.0 0.014 15.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 AIC16035.1 - 0.008 16.1 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 NTPase RNA_helicase PF00910.22 AIC16035.1 - 0.009 16.4 0.0 0.016 15.6 0.0 1.4 1 0 0 1 1 1 1 RNA helicase AAA_18 PF13238.6 AIC16035.1 - 0.011 16.3 0.0 0.021 15.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 AIC16035.1 - 0.012 15.4 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 AIC16035.1 - 0.014 15.1 0.1 0.028 14.2 0.1 1.5 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 AIC16035.1 - 0.015 14.8 0.0 0.031 13.7 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_35 PF14516.6 AIC16035.1 - 0.015 14.1 0.0 0.044 12.6 0.0 1.7 1 1 1 2 2 2 0 AAA-like domain CbbQ_C PF08406.10 AIC16035.1 - 0.019 15.2 0.1 0.033 14.4 0.1 1.4 1 0 0 1 1 1 0 CbbQ/NirQ/NorQ C-terminal IstB_IS21 PF01695.17 AIC16035.1 - 0.022 14.5 0.0 0.039 13.7 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ATPase PF06745.13 AIC16035.1 - 0.026 13.9 0.0 0.041 13.2 0.0 1.3 1 0 0 1 1 1 0 KaiC RsgA_GTPase PF03193.16 AIC16035.1 - 0.027 14.4 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase T2SSE PF00437.20 AIC16035.1 - 0.031 13.3 0.0 0.062 12.4 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein MobB PF03205.14 AIC16035.1 - 0.033 14.1 0.1 0.061 13.2 0.1 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B Rad17 PF03215.15 AIC16035.1 - 0.047 13.6 0.0 0.063 13.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 AIC16035.1 - 0.048 13.2 0.4 0.12 11.9 0.1 1.8 2 0 0 2 2 2 0 AAA domain ATP_bind_1 PF03029.17 AIC16035.1 - 0.062 13.1 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein DnaB_C PF03796.15 AIC16035.1 - 0.068 12.5 0.0 0.099 12.0 0.0 1.2 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain AAA_19 PF13245.6 AIC16035.1 - 0.072 13.4 1.0 0.22 11.9 1.0 1.9 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 AIC16035.1 - 0.1 11.7 0.0 0.14 11.3 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain DUF815 PF05673.13 AIC16035.1 - 0.11 11.7 0.1 0.24 10.6 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF815) AAA_23 PF13476.6 AIC16035.1 - 0.12 12.9 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain Hemerythrin PF01814.23 AIC16036.1 - 2.6e-11 44.3 3.2 6.4e-10 39.8 0.7 1.9 1 1 1 2 2 2 2 Hemerythrin HHE cation binding domain Cu-oxidase_3 PF07732.15 AIC16037.1 - 3.8e-27 94.7 2.2 8.7e-22 77.4 0.0 2.6 3 0 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIC16037.1 - 1.7e-21 76.4 5.3 1.3e-10 41.2 0.1 3.9 4 0 0 4 4 4 3 Multicopper oxidase Copper-bind PF00127.20 AIC16037.1 - 5.2e-11 42.9 1.4 1.6e-05 25.3 0.1 3.9 2 2 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC16037.1 - 1.9e-08 34.4 0.0 0.00024 21.1 0.0 3.7 3 1 0 3 3 3 2 Cupredoxin-like domain Cu-oxidase PF00394.22 AIC16037.1 - 0.0013 18.9 0.0 0.13 12.3 0.0 2.8 2 0 0 2 2 2 1 Multicopper oxidase SH3_2 PF07653.17 AIC16037.1 - 0.066 12.9 0.0 11 5.8 0.0 2.5 2 0 0 2 2 2 0 Variant SH3 domain Arch_flagellin PF01917.16 AIC16037.1 - 5 7.3 6.7 6.7 6.9 3.0 2.6 2 1 1 3 3 3 0 Archaebacterial flagellin ABM PF03992.16 AIC16038.1 - 7.5e-06 26.0 0.1 1.1e-05 25.5 0.1 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase SOR PF07682.11 AIC16038.1 - 0.0017 17.3 0.1 0.0018 17.2 0.1 1.1 1 0 0 1 1 1 1 Sulphur oxygenase reductase TauD PF02668.16 AIC16038.1 - 0.0025 17.6 0.0 0.0031 17.4 0.0 1.0 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF3408 PF11888.8 AIC16038.1 - 0.059 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CopG_antitoxin PF12441.8 AIC16039.1 - 0.0011 19.4 0.4 0.018 15.6 0.0 2.5 2 1 1 3 3 3 1 CopG antitoxin of type II toxin-antitoxin system U5_2-snRNA_bdg PF10597.9 AIC16042.1 - 0.056 13.5 0.0 0.079 13.0 0.0 1.2 1 0 0 1 1 1 0 U5-snRNA binding site 2 of PrP8 F420H2_quin_red PF04075.14 AIC16044.1 - 1.3e-12 48.0 0.0 1.6e-12 47.7 0.0 1.0 1 0 0 1 1 1 1 F420H(2)-dependent quinone reductase DUF2255 PF10012.9 AIC16044.1 - 8.8e-05 22.6 0.2 0.00011 22.3 0.2 1.2 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2255) DUF4389 PF14333.6 AIC16045.1 - 0.52 10.3 3.1 0.81 9.6 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) DUF4342 PF14242.6 AIC16046.1 - 6.2e-24 83.8 1.9 8e-24 83.4 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4342) zinc_ribbon_2 PF13240.6 AIC16046.1 - 9.8e-09 34.7 4.1 1.8e-08 33.8 4.1 1.5 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIC16046.1 - 1.5e-06 28.1 0.6 2.5e-06 27.4 0.6 1.3 1 0 0 1 1 1 1 Double zinc ribbon UPF0547 PF10571.9 AIC16046.1 - 3.7e-06 26.9 4.2 6.3e-06 26.2 4.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 zinc_ribbon_15 PF17032.5 AIC16046.1 - 0.00076 20.2 2.0 0.0015 19.2 2.0 1.5 1 0 0 1 1 1 1 zinc-ribbon family zf-NADH-PPase PF09297.11 AIC16046.1 - 0.0081 15.8 0.1 0.016 14.8 0.1 1.5 1 0 0 1 1 1 1 NADH pyrophosphatase zinc ribbon domain zf-ribbon_3 PF13248.6 AIC16046.1 - 0.03 13.7 3.7 0.077 12.4 3.8 1.6 1 1 0 1 1 1 0 zinc-ribbon domain PknG_rubred PF16919.5 AIC16046.1 - 0.034 14.3 0.5 0.054 13.7 0.5 1.4 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain zinc-ribbons_6 PF07191.12 AIC16046.1 - 0.053 13.5 0.6 0.053 13.5 0.6 1.5 2 0 0 2 2 1 0 zinc-ribbons NOB1_Zn_bind PF08772.11 AIC16046.1 - 0.059 13.5 0.1 0.089 13.0 0.1 1.4 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like FlgD_ig PF13860.6 AIC16046.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.3 1 0 0 1 1 1 0 FlgD Ig-like domain HypA PF01155.19 AIC16046.1 - 0.13 12.3 3.4 0.13 12.3 2.2 1.7 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-IS66 PF13005.7 AIC16046.1 - 0.13 12.7 1.9 1.1 9.7 0.0 2.4 2 1 0 2 2 2 0 zinc-finger binding domain of transposase IS66 TMEM40 PF15817.5 AIC16046.1 - 0.18 11.6 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 Transmembrane protein 40 family Nudix_N_2 PF14803.6 AIC16046.1 - 0.28 11.2 0.2 0.28 11.2 0.2 2.0 2 0 0 2 2 2 0 Nudix N-terminal zf_UBZ PF18439.1 AIC16046.1 - 0.28 10.8 2.6 7.2 6.3 0.2 2.4 1 1 1 2 2 2 0 Ubiquitin-Binding Zinc Finger ADK_lid PF05191.14 AIC16046.1 - 0.87 9.6 4.0 16 5.6 0.3 2.5 2 1 0 3 3 2 0 Adenylate kinase, active site lid TF_Zn_Ribbon PF08271.12 AIC16046.1 - 1.2 8.7 4.2 6.3 6.4 4.2 2.1 1 1 0 1 1 1 0 TFIIB zinc-binding Zn-ribbon_8 PF09723.10 AIC16046.1 - 4.6 7.5 6.0 79 3.5 1.1 2.3 1 1 1 2 2 2 0 Zinc ribbon domain AP_endonuc_2 PF01261.24 AIC16047.1 - 3.2e-11 43.1 0.2 6.2e-10 38.9 0.2 2.2 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel Glyco_hydro_129 PF11308.8 AIC16047.1 - 0.18 10.9 0.0 0.33 10.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases related to GH101 family, GH129 Polysacc_deac_1 PF01522.21 AIC16048.1 - 3.9e-12 46.2 0.0 6.6e-12 45.4 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Glyco_hydro_57 PF03065.15 AIC16048.1 - 0.0085 15.3 0.0 0.01 15.1 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 57 Rimk_N PF18030.1 AIC16048.1 - 0.046 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 RimK PreATP-grasp domain Mrx7 PF10906.8 AIC16049.1 - 9.9 6.5 13.2 2.7 8.3 1.6 3.4 2 2 2 4 4 4 0 MIOREX complex component 7 Pterin_4a PF01329.19 AIC16053.1 - 6.3e-30 103.2 0.0 6.8e-30 103.1 0.0 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase Big_7 PF17957.1 AIC16054.1 - 3.3e-13 50.2 6.7 3.3e-13 50.2 6.7 1.9 1 1 1 2 2 2 1 Bacterial Ig domain DUF4625 PF15418.6 AIC16054.1 - 0.004 17.4 0.1 0.3 11.3 0.1 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4625) Gmad2 PF10648.9 AIC16054.1 - 0.0041 17.3 0.9 0.013 15.7 0.5 2.1 1 1 0 1 1 1 1 Immunoglobulin-like domain of bacterial spore germination Big_6 PF17936.1 AIC16054.1 - 0.013 15.8 0.8 0.027 14.7 0.3 2.0 1 1 0 1 1 1 0 Bacterial Ig domain Cadherin_5 PF17892.1 AIC16054.1 - 0.041 13.9 2.0 0.051 13.6 1.6 1.4 1 1 0 1 1 1 0 Cadherin-like domain Pkinase PF00069.25 AIC16055.1 - 3.4e-38 131.5 0.0 4.3e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 AIC16055.1 - 4.7e-24 85.1 0.0 5.8e-24 84.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 AIC16055.1 - 0.00043 20.3 0.1 0.31 10.9 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 AIC16055.1 - 0.1 11.9 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family VCBS PF13517.6 AIC16056.1 - 5.4e-13 49.3 13.9 8.9e-07 29.4 2.1 3.6 2 1 2 4 4 4 4 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF756 PF05506.12 AIC16056.1 - 0.01 16.7 1.2 11 7.0 0.1 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF756) DUF4861 PF16153.5 AIC16056.1 - 0.041 12.8 6.9 0.77 8.7 0.5 3.5 1 1 3 4 4 4 0 Domain of unknown function (DUF4861) Methyltransf_11 PF08241.12 AIC16056.1 - 0.049 14.3 0.8 14 6.4 0.0 3.6 1 1 3 4 4 4 0 Methyltransferase domain Ubie_methyltran PF01209.18 AIC16056.1 - 0.061 12.7 0.6 14 4.9 0.0 3.3 1 1 1 3 3 3 0 ubiE/COQ5 methyltransferase family DUF4303 PF14136.6 AIC16056.1 - 0.11 12.2 2.2 4.7 6.9 0.1 3.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4303) HORMA PF02301.18 AIC16056.1 - 0.35 10.4 1.3 23 4.5 0.3 2.9 1 1 1 2 2 2 0 HORMA domain FG-GAP PF01839.23 AIC16056.1 - 6.8 6.9 14.2 12 6.1 0.1 4.5 4 0 0 4 4 4 0 FG-GAP repeat Hexapep PF00132.24 AIC16057.1 - 1.2e-11 43.8 10.7 0.00021 20.9 0.1 4.6 3 1 1 4 4 4 4 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 AIC16057.1 - 4.2e-05 23.2 6.7 0.0059 16.3 1.4 4.3 3 1 1 4 4 4 2 Hexapeptide repeat of succinyl-transferase MFS_1 PF07690.16 AIC16058.1 - 3.3e-34 118.4 38.9 3.3e-34 118.4 38.9 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 AIC16058.1 - 2.4e-05 23.4 4.4 2.4e-05 23.4 4.4 3.0 1 1 1 2 2 2 1 MFS_1 like family Glyoxalase PF00903.25 AIC16060.1 - 3.1e-07 30.6 0.0 5.3e-07 29.9 0.0 1.4 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 AIC16060.1 - 0.00078 19.4 0.0 0.0037 17.2 0.0 1.9 1 1 0 1 1 1 1 Glyoxalase-like domain Lon_C PF05362.13 AIC16061.1 - 5.9e-13 48.8 2.7 1.4e-12 47.6 2.7 1.6 1 1 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.6 AIC16061.1 - 0.0064 16.3 0.1 0.019 14.8 0.1 1.8 2 0 0 2 2 2 1 Subunit ChlI of Mg-chelatase RskA PF10099.9 AIC16062.1 - 0.058 13.7 0.1 0.21 11.8 0.0 2.0 3 0 0 3 3 3 0 Anti-sigma-K factor rskA Multi_ubiq PF14452.6 AIC16063.1 - 0.079 13.2 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Multiubiquitin C5-epim_C PF06662.13 AIC16065.1 - 3.2e-17 62.6 3.2 7.3e-17 61.5 3.2 1.6 1 1 0 1 1 1 1 D-glucuronyl C5-epimerase C-terminus Glyco_hydro_127 PF07944.12 AIC16065.1 - 0.00083 18.0 0.7 0.0098 14.4 0.7 2.0 1 1 1 2 2 2 2 Beta-L-arabinofuranosidase, GH127 DUF1326 PF07040.11 AIC16066.1 - 1.5e-50 171.7 0.0 1.8e-50 171.5 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1326) Cellulase PF00150.18 AIC16068.1 - 1.5e-14 54.2 2.3 5.6e-14 52.2 2.3 1.8 1 1 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AP_endonuc_2 PF01261.24 AIC16068.1 - 0.016 14.6 0.0 0.74 9.2 0.0 2.4 1 1 0 1 1 1 0 Xylose isomerase-like TIM barrel NitrOD5 PF11537.8 AIC16070.1 - 0.0031 17.6 0.0 0.0034 17.5 0.0 1.1 1 0 0 1 1 1 1 Nitrosopumilus output domain 5 SicP-binding PF09119.10 AIC16070.1 - 0.16 11.9 0.0 0.19 11.7 0.0 1.1 1 0 0 1 1 1 0 SicP binding TackOD1 PF18551.1 AIC16071.1 - 2.3e-29 102.4 1.7 2.8e-29 102.1 1.7 1.1 1 0 0 1 1 1 1 Thaumarchaeal output domain 1 Zn-ribbon_8 PF09723.10 AIC16071.1 - 0.00088 19.3 16.2 0.099 12.8 0.8 4.4 3 1 1 4 4 4 2 Zinc ribbon domain zf_UBZ PF18439.1 AIC16071.1 - 0.0081 15.7 8.2 2.2 8.0 0.3 4.3 4 0 0 4 4 4 1 Ubiquitin-Binding Zinc Finger Ribosomal_L37ae PF01780.19 AIC16071.1 - 0.031 14.4 2.4 0.099 12.7 0.8 2.3 1 1 1 2 2 2 0 Ribosomal L37ae protein family zinc-ribbons_6 PF07191.12 AIC16071.1 - 0.036 14.0 9.3 0.72 9.9 1.7 2.9 1 1 1 2 2 2 0 zinc-ribbons OrfB_Zn_ribbon PF07282.11 AIC16071.1 - 0.037 13.9 0.6 0.037 13.9 0.6 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain C1_1 PF00130.22 AIC16071.1 - 0.096 12.6 6.0 0.25 11.3 1.1 2.4 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.10 AIC16071.1 - 0.21 11.4 10.5 0.57 10.0 0.2 3.7 4 0 0 4 4 4 0 A2L zinc ribbon domain zf-C2H2 PF00096.26 AIC16071.1 - 0.24 11.9 9.7 1.7 9.3 1.1 3.7 3 0 0 3 3 3 0 Zinc finger, C2H2 type HypA PF01155.19 AIC16071.1 - 0.29 11.1 8.3 11 6.1 0.3 3.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF35_N PF12172.8 AIC16071.1 - 0.31 11.0 7.6 6 6.9 0.3 3.2 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 AIC16071.1 - 0.34 11.0 8.3 9.8 6.3 8.4 2.6 1 1 1 2 2 2 0 Double zinc ribbon CpXC PF14353.6 AIC16071.1 - 1.1 9.3 6.0 2.2 8.4 0.8 3.2 3 0 0 3 3 3 0 CpXC protein zf-ribbon_3 PF13248.6 AIC16071.1 - 1.8 8.1 10.6 0.58 9.6 1.3 3.3 3 1 1 4 4 4 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 AIC16071.1 - 4.1 7.5 12.7 0.9 9.6 1.4 3.3 2 1 1 3 3 3 0 Transposase zinc-ribbon domain zf-C2H2_6 PF13912.6 AIC16071.1 - 4.6 7.3 6.9 6.3 6.9 0.6 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C6H2 PF15801.5 AIC16071.1 - 6 7.3 7.5 44 4.5 3.5 3.1 2 1 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding Glyco_tranf_2_3 PF13641.6 AIC16072.1 - 5.7e-28 98.4 0.0 7.4e-28 98.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_trans_2_3 PF13632.6 AIC16072.1 - 4.4e-24 85.5 2.9 4.4e-24 85.5 2.9 1.7 2 0 0 2 2 2 1 Glycosyl transferase family group 2 Glycos_transf_2 PF00535.26 AIC16072.1 - 4.8e-14 52.5 0.0 7e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_transf_21 PF13506.6 AIC16072.1 - 2.9e-09 36.6 0.1 4.9e-09 35.9 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 21 Phage_holin_3_6 PF07332.11 AIC16072.1 - 0.19 11.8 7.6 0.088 12.8 0.9 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III SelR PF01641.18 AIC16074.1 - 6.2e-40 136.0 0.0 7.9e-40 135.7 0.0 1.0 1 0 0 1 1 1 1 SelR domain zf_UBZ PF18439.1 AIC16074.1 - 0.0075 15.8 1.0 0.93 9.1 0.1 2.3 2 0 0 2 2 2 2 Ubiquitin-Binding Zinc Finger zf-CCHC_2 PF13696.6 AIC16074.1 - 0.011 15.5 0.7 0.011 15.5 0.7 2.2 2 0 0 2 2 2 0 Zinc knuckle Ribosomal_L37e PF01907.19 AIC16074.1 - 0.016 15.3 4.1 0.11 12.7 0.3 2.3 2 0 0 2 2 2 0 Ribosomal protein L37e Yippee-Mis18 PF03226.14 AIC16074.1 - 0.037 14.2 0.4 1.8 8.8 0.0 2.3 2 1 1 3 3 3 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly TF_Zn_Ribbon PF08271.12 AIC16074.1 - 0.068 12.7 0.6 3.2 7.4 0.1 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding zf-HIT PF04438.16 AIC16074.1 - 0.15 11.9 2.0 0.96 9.4 0.3 2.2 2 0 0 2 2 2 0 HIT zinc finger HECT_2 PF09814.9 AIC16074.1 - 0.16 10.8 0.1 6.5 5.5 0.0 2.1 2 0 0 2 2 2 0 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DZR PF12773.7 AIC16074.1 - 0.17 11.9 2.4 1.2 9.2 2.4 2.2 1 1 0 1 1 1 0 Double zinc ribbon zf-RRN7 PF11781.8 AIC16074.1 - 2 8.2 6.3 0.69 9.6 1.2 2.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 PMSR PF01625.21 AIC16075.1 - 1.3e-65 220.3 0.2 1.5e-65 220.0 0.2 1.0 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase HEPN_Cthe2314 PF18730.1 AIC16076.1 - 1.6e-07 31.6 1.1 2e-07 31.2 1.1 1.1 1 0 0 1 1 1 1 Cthe_2314-like HEPN UvsY PF11056.8 AIC16076.1 - 0.1 12.9 1.4 24 5.3 0.3 3.0 2 1 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY DUF4993 PF16384.5 AIC16079.1 - 0.0045 16.1 1.4 0.006 15.6 1.4 1.1 1 0 0 1 1 1 1 Domain of unknown function DUF677 PF05055.12 AIC16080.1 - 0.034 13.1 0.5 0.046 12.6 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF677) DUF460 PF04312.13 AIC16081.1 - 0.00087 19.0 0.1 0.0017 18.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF460) RuvX PF03652.15 AIC16081.1 - 0.048 14.1 0.1 0.42 11.0 0.1 2.1 1 1 0 1 1 1 0 Holliday junction resolvase Herpes_US12 PF05363.12 AIC16081.1 - 0.13 13.0 0.1 0.27 12.0 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus US12 family V-ATPase_G_2 PF16999.5 AIC16082.1 - 3.7e-05 24.1 29.8 0.0016 18.9 12.2 2.0 1 1 1 2 2 2 2 Vacuolar (H+)-ATPase G subunit Mitofilin PF09731.9 AIC16082.1 - 0.0015 17.5 8.8 0.0018 17.2 8.8 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein Exonuc_VII_L PF02601.15 AIC16082.1 - 0.0047 16.5 3.5 0.0055 16.3 3.5 1.0 1 0 0 1 1 1 1 Exonuclease VII, large subunit COG6 PF06419.11 AIC16082.1 - 0.005 15.1 6.9 0.038 12.2 5.6 1.9 1 1 1 2 2 2 2 Conserved oligomeric complex COG6 DUF5471 PF17565.2 AIC16082.1 - 0.0058 16.9 1.2 0.0099 16.1 0.9 1.6 1 1 0 1 1 1 1 Family of unknown function (DUF5471) Apolipoprotein PF01442.18 AIC16082.1 - 0.006 16.5 5.6 0.0078 16.1 5.6 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Activator-TraM PF11657.8 AIC16082.1 - 0.0065 16.3 5.3 0.0084 15.9 5.3 1.3 1 0 0 1 1 1 1 Transcriptional activator TraM Phage_Mu_Gam PF07352.12 AIC16082.1 - 0.014 15.3 9.9 0.029 14.3 0.6 2.2 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein AAA_15 PF13175.6 AIC16082.1 - 0.016 14.9 2.6 0.02 14.6 2.6 1.3 1 0 0 1 1 1 0 AAA ATPase domain DUF826 PF05696.11 AIC16082.1 - 0.017 15.2 3.9 0.046 13.8 0.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF826) MIF4G_like_2 PF09090.11 AIC16082.1 - 0.022 14.3 4.5 0.028 13.9 4.5 1.2 1 0 0 1 1 1 0 MIF4G like ATP-synt_B PF00430.18 AIC16082.1 - 0.022 14.8 12.7 0.031 14.4 12.3 1.5 1 1 0 1 1 1 0 ATP synthase B/B' CF(0) KxDL PF10241.9 AIC16082.1 - 0.038 14.2 3.3 4.3 7.7 1.0 2.3 1 1 0 2 2 2 0 Uncharacterized conserved protein 5_nucleotid PF05761.14 AIC16082.1 - 0.043 12.7 2.9 0.055 12.4 2.9 1.0 1 0 0 1 1 1 0 5' nucleotidase family Phasin PF05597.11 AIC16082.1 - 0.049 13.6 8.3 1.2 9.2 1.9 2.4 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF4456 PF14644.6 AIC16082.1 - 0.05 13.3 4.4 0.29 10.8 3.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4456) Allexi_40kDa PF05549.11 AIC16082.1 - 0.062 12.8 2.2 0.073 12.6 2.2 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein TipAS PF07739.13 AIC16082.1 - 0.09 13.3 3.5 0.17 12.4 3.5 1.5 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain DUF3552 PF12072.8 AIC16082.1 - 0.095 12.1 14.3 0.096 12.1 9.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Muted PF14942.6 AIC16082.1 - 0.12 12.7 8.3 0.21 11.9 8.3 1.4 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF883 PF05957.13 AIC16082.1 - 0.15 12.7 9.9 0.39 11.3 6.5 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) SCAB_CC PF16712.5 AIC16082.1 - 0.19 11.5 10.5 0.34 10.7 10.4 1.5 1 1 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein DUF2894 PF11445.8 AIC16082.1 - 0.22 12.0 2.5 0.27 11.7 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2894) DUF2175 PF09943.9 AIC16082.1 - 0.26 11.6 5.6 0.6 10.4 5.6 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Fzo_mitofusin PF04799.13 AIC16082.1 - 0.27 10.8 4.2 1.4 8.5 1.7 2.0 1 1 1 2 2 2 0 fzo-like conserved region DUF1664 PF07889.12 AIC16082.1 - 0.27 11.3 8.2 0.21 11.6 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DivIVA PF05103.13 AIC16082.1 - 0.35 11.0 15.0 0.56 10.3 12.2 2.1 1 1 1 2 2 2 0 DivIVA protein KfrA_N PF11740.8 AIC16082.1 - 0.42 11.3 7.7 7.4 7.3 7.9 2.2 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term YabA PF06156.13 AIC16082.1 - 0.49 11.1 6.0 0.51 11.0 4.9 1.6 1 1 1 2 2 2 0 Initiation control protein YabA TMPIT PF07851.13 AIC16082.1 - 0.5 9.6 5.5 0.66 9.2 5.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein FlaC_arch PF05377.11 AIC16082.1 - 0.73 10.3 9.5 0.96 9.9 2.4 2.4 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4407 PF14362.6 AIC16082.1 - 1.1 8.5 7.0 2.2 7.5 7.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Prominin PF05478.11 AIC16082.1 - 1.5 6.6 5.1 2.5 6.0 5.1 1.4 1 1 0 1 1 1 0 Prominin COG2 PF06148.11 AIC16082.1 - 1.6 8.8 8.0 1 9.4 5.6 1.9 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 XhlA PF10779.9 AIC16082.1 - 1.7 8.9 9.6 2.9 8.2 2.2 3.0 1 1 1 2 2 2 0 Haemolysin XhlA LPP PF04728.13 AIC16082.1 - 2.2 8.7 8.2 1.1e+02 3.3 8.2 2.6 1 1 0 1 1 1 0 Lipoprotein leucine-zipper DUF1690 PF07956.11 AIC16082.1 - 2.5 8.5 9.8 0.16 12.4 1.3 2.1 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) Spc24 PF08286.11 AIC16082.1 - 5.7 7.2 8.3 47 4.3 8.3 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 NAC PF01849.18 AIC16083.1 - 1.3e-12 47.5 4.1 4.6e-11 42.5 1.6 2.1 1 1 1 2 2 2 2 NAC domain HOIP-UBA PF16678.5 AIC16083.1 - 0.0024 17.9 0.1 0.0033 17.5 0.1 1.2 1 0 0 1 1 1 1 HOIP UBA domain pair T2SSF PF00482.23 AIC16083.1 - 0.045 13.7 0.5 2.2 8.3 0.0 2.0 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F PUA PF01472.20 AIC16084.1 - 8.9e-11 41.6 0.4 1.4e-10 41.0 0.4 1.3 1 0 0 1 1 1 1 PUA domain TGT_C2 PF14810.6 AIC16084.1 - 1.8e-09 37.6 0.0 2.6e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 Patch-forming domain C2 of tRNA-guanine transglycosylase UPF0113 PF03657.13 AIC16084.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 UPF0113 PUA domain PhoU PF01895.19 AIC16085.1 - 1.9e-25 89.1 15.9 9e-18 64.5 3.6 2.7 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 AIC16085.1 - 1.1e-09 38.0 0.0 3.3e-09 36.4 0.0 1.8 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin ORF45 PF17620.2 AIC16085.1 - 0.09 12.9 0.6 0.25 11.4 0.1 1.8 1 1 1 2 2 2 0 Family of unknown function HTH_3 PF01381.22 AIC16086.1 - 2.6e-05 24.2 0.1 3.9e-05 23.6 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 AIC16086.1 - 0.0026 18.0 0.0 0.0039 17.5 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain zf-dskA_traR PF01258.17 AIC16086.1 - 0.011 15.7 0.8 0.036 14.0 0.8 1.9 1 1 0 1 1 1 0 Prokaryotic dksA/traR C4-type zinc finger HTH_25 PF13413.6 AIC16086.1 - 0.084 12.7 0.1 0.15 12.0 0.1 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain GTP-bdg_N PF13167.6 AIC16087.1 - 1.7e-21 76.7 0.9 4.2e-21 75.4 0.2 2.1 2 0 0 2 2 2 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 AIC16087.1 - 4.5e-17 62.2 0.1 2.6e-16 59.7 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP-bdg_M PF16360.5 AIC16087.1 - 2.2e-13 50.6 5.7 5.3e-13 49.4 5.7 1.7 1 0 0 1 1 1 1 GTP-binding GTPase Middle Region FeoB_N PF02421.18 AIC16087.1 - 3.9e-08 33.0 0.0 1.2e-07 31.4 0.0 1.9 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AIC16087.1 - 0.00028 20.8 0.7 0.18 11.7 0.0 2.6 3 0 0 3 3 3 2 RsgA GTPase GTP_EFTU PF00009.27 AIC16087.1 - 0.0004 20.0 0.2 0.18 11.3 0.0 2.8 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 AIC16087.1 - 0.00059 19.8 0.0 0.002 18.1 0.0 1.8 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain SRPRB PF09439.10 AIC16087.1 - 0.003 17.0 0.2 0.003 17.0 0.2 2.4 2 1 1 3 3 3 1 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 AIC16087.1 - 0.0044 17.5 0.1 0.018 15.6 0.0 2.2 1 1 1 2 2 2 1 ABC transporter Dynamin_N PF00350.23 AIC16087.1 - 0.014 15.5 0.2 0.34 11.0 0.1 2.7 1 1 1 2 2 2 0 Dynamin family AAA_23 PF13476.6 AIC16087.1 - 1.1 9.7 5.9 1.7 9.1 0.4 2.4 2 0 0 2 2 2 0 AAA domain Trm56 PF01994.16 AIC16088.1 - 6.5e-52 174.5 0.1 8.7e-52 174.1 0.1 1.2 1 0 0 1 1 1 1 tRNA ribose 2'-O-methyltransferase, aTrm56 Glyoxalase_4 PF13669.6 AIC16088.1 - 0.042 14.1 0.0 0.057 13.7 0.0 1.3 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AHSA1 PF08327.11 AIC16089.1 - 4.5e-24 85.1 0.1 5e-24 84.9 0.1 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIC16089.1 - 0.0042 17.4 0.1 0.0066 16.7 0.1 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 AIC16090.1 - 8.6e-25 87.4 0.2 1.3e-24 86.9 0.2 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIC16090.1 - 2.9e-12 47.1 2.8 1.8e-11 44.5 1.5 2.0 2 0 0 2 2 2 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIC16090.1 - 0.001 19.3 0.1 0.0016 18.7 0.1 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport HTH_5 PF01022.20 AIC16091.1 - 4.8e-14 52.0 0.0 6.4e-14 51.5 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC16091.1 - 1.9e-13 50.2 0.1 3.3e-13 49.5 0.1 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 AIC16091.1 - 1.5e-06 28.0 0.1 2.8e-06 27.1 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 AIC16091.1 - 0.0011 18.4 0.0 0.0021 17.5 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 AIC16091.1 - 0.0073 16.2 0.2 0.013 15.4 0.1 1.5 2 0 0 2 2 2 1 MarR family TrmB PF01978.19 AIC16091.1 - 0.0097 15.8 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB DUF4423 PF14394.6 AIC16091.1 - 0.033 13.9 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) Rrf2 PF02082.20 AIC16091.1 - 0.043 14.2 0.0 0.065 13.6 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator HTH_34 PF13601.6 AIC16091.1 - 0.079 13.2 0.0 0.15 12.2 0.0 1.5 1 1 0 1 1 1 0 Winged helix DNA-binding domain HTH_28 PF13518.6 AIC16091.1 - 0.11 12.7 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 AIC16091.1 - 0.11 12.5 0.1 0.16 12.0 0.1 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain AMP-binding PF00501.28 AIC16093.1 - 1.5e-84 284.1 0.0 1.8e-84 283.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 AIC16093.1 - 7.3e-23 81.3 2.8 1.5e-22 80.4 2.8 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 AIC16093.1 - 3.6e-10 39.6 1.1 9.2e-10 38.3 1.1 1.8 1 0 0 1 1 1 1 Acetyl-coenzyme A synthetase N-terminus Peptidase_M1 PF01433.20 AIC16094.1 - 3.2e-55 187.1 1.6 6e-55 186.2 1.6 1.5 1 0 0 1 1 1 1 Peptidase family M1 domain HEAT_2 PF13646.6 AIC16094.1 - 2.6e-37 127.1 12.9 1.6e-11 44.4 0.0 3.7 1 1 4 5 5 5 5 HEAT repeats Peptidase_M1_N PF17900.1 AIC16094.1 - 3e-26 92.7 0.0 9.9e-26 91.1 0.0 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain HEAT_PBS PF03130.16 AIC16094.1 - 6.7e-12 44.9 9.8 0.035 14.8 0.3 5.9 6 0 0 6 6 6 5 PBS lyase HEAT-like repeat HEAT PF02985.22 AIC16094.1 - 3.9e-05 23.6 5.8 2.6 8.5 0.0 5.1 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 AIC16094.1 - 0.022 14.8 0.1 0.087 12.9 0.1 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 AIC16094.1 - 0.13 12.8 3.5 1.2 9.7 0.3 2.9 2 1 0 2 2 2 0 HEAT-like repeat DHR10 PF18595.1 AIC16094.1 - 0.17 12.0 4.8 0.62 10.1 0.6 2.5 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Abhydrolase_1 PF00561.20 AIC16095.1 - 4e-26 92.2 0.0 2.7e-24 86.2 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIC16095.1 - 5.6e-24 86.0 0.0 6.6e-24 85.7 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 AIC16095.1 - 5.9e-17 61.7 0.0 7.5e-17 61.4 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 AIC16095.1 - 0.00061 19.5 0.1 0.00086 19.0 0.1 1.3 1 0 0 1 1 1 1 Putative esterase Thioesterase PF00975.20 AIC16095.1 - 0.0083 16.3 0.0 0.013 15.7 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Abhydrolase_3 PF07859.13 AIC16095.1 - 0.03 14.2 0.2 0.055 13.3 0.2 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold DUF2048 PF09752.9 AIC16095.1 - 0.046 12.8 0.0 0.062 12.4 0.0 1.2 1 0 0 1 1 1 0 Abhydrolase domain containing 18 Abhydrolase_2 PF02230.16 AIC16095.1 - 0.23 11.2 0.0 14 5.4 0.0 2.8 3 0 0 3 3 3 0 Phospholipase/Carboxylesterase Acetyltransf_1 PF00583.25 AIC16096.1 - 3e-14 53.2 0.0 5.5e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_3 PF13302.7 AIC16096.1 - 4.3e-10 40.4 0.2 2.5e-09 37.9 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIC16096.1 - 1.8e-06 27.9 0.0 3.8e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 AIC16096.1 - 2.5e-06 27.8 0.0 5.7e-06 26.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 AIC16096.1 - 2.2e-05 24.5 0.3 0.0002 21.4 0.2 2.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIC16096.1 - 0.004 17.1 0.0 0.0085 16.0 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein PanZ PF12568.8 AIC16096.1 - 0.0096 15.6 0.1 0.16 11.7 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain, PanZ WSD PF15613.6 AIC16096.1 - 0.064 13.7 0.0 0.17 12.3 0.0 1.8 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Amb_V_allergen PF03913.13 AIC16096.1 - 0.1 12.5 0.2 0.83 9.6 0.0 2.2 2 0 0 2 2 2 0 Amb V Allergen dCMP_cyt_deam_1 PF00383.23 AIC16098.1 - 4.7e-25 87.4 0.9 6.8e-25 86.9 0.9 1.2 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 AIC16098.1 - 6.6e-17 61.6 0.0 8.8e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 AIC16098.1 - 0.038 14.1 0.3 0.074 13.2 0.3 1.5 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC_N PF08210.11 AIC16098.1 - 0.064 13.2 0.3 0.16 11.8 0.3 1.8 1 1 0 1 1 1 0 APOBEC-like N-terminal domain NAD1 PF18778.1 AIC16098.1 - 0.12 12.4 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 RecX PF02631.16 AIC16099.1 - 0.015 15.8 0.0 0.023 15.1 0.0 1.4 1 0 0 1 1 1 0 RecX family PTS_EIIC PF02378.18 AIC16101.1 - 0.022 13.8 1.2 0.024 13.7 1.2 1.0 1 0 0 1 1 1 0 Phosphotransferase system, EIIC Thioredoxin_3 PF13192.6 AIC16102.1 - 0.00014 21.9 0.1 0.00018 21.5 0.1 1.1 1 0 0 1 1 1 1 Thioredoxin domain DUF4920 PF16267.5 AIC16102.1 - 0.076 13.0 0.1 0.076 13.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4920) DUF4662 PF15578.6 AIC16103.1 - 0.091 12.5 0.0 0.091 12.5 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) DNA_pol_B_thumb PF14791.6 AIC16104.1 - 6.6e-21 74.2 0.1 1.8e-20 72.8 0.1 1.8 1 0 0 1 1 1 1 DNA polymerase beta thumb HHH_8 PF14716.6 AIC16104.1 - 4.6e-18 65.4 6.0 5.3e-17 62.0 1.2 3.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain HHH_5 PF14520.6 AIC16104.1 - 4.9e-10 39.9 9.2 4.8e-06 27.1 1.3 3.2 1 1 2 3 3 3 3 Helix-hairpin-helix domain PHP PF02811.19 AIC16104.1 - 3.1e-07 30.8 0.1 6.3e-07 29.8 0.1 1.6 1 0 0 1 1 1 1 PHP domain HHH PF00633.23 AIC16104.1 - 0.00014 21.6 6.5 0.03 14.2 0.2 3.7 4 0 0 4 4 4 2 Helix-hairpin-helix motif HHH_3 PF12836.7 AIC16104.1 - 0.00015 21.9 0.6 0.018 15.3 0.2 3.3 2 1 0 2 2 2 1 Helix-hairpin-helix motif RNase_P_p30 PF01876.16 AIC16104.1 - 0.0007 19.1 0.0 0.0075 15.8 0.0 2.3 1 1 1 2 2 2 1 RNase P subunit p30 HHH_2 PF12826.7 AIC16104.1 - 0.0019 18.3 0.0 0.36 11.0 0.0 2.8 1 1 2 3 3 3 1 Helix-hairpin-helix motif DNA_pol_B_palm PF14792.6 AIC16104.1 - 0.0038 17.4 0.0 0.011 15.9 0.0 1.7 1 0 0 1 1 1 1 DNA polymerase beta palm IMS_HHH PF11798.8 AIC16104.1 - 0.084 13.2 0.1 17 6.0 0.0 3.4 2 1 1 3 3 3 0 IMS family HHH motif Abhydrolase_9_N PF15420.6 AIC16105.1 - 0.0026 17.8 2.2 0.0031 17.5 2.2 1.2 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus Glucos_trans_II PF14264.6 AIC16105.1 - 0.0057 16.0 3.5 0.026 13.9 1.8 2.0 2 0 0 2 2 2 1 Glucosyl transferase GtrII DUF4153 PF13687.6 AIC16105.1 - 0.07 12.8 6.4 0.66 9.6 2.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4153) COX7a PF02238.15 AIC16105.1 - 0.072 13.5 1.3 0.3 11.5 1.3 2.1 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII Na_K-ATPase PF00287.18 AIC16105.1 - 0.16 11.1 0.4 0.24 10.5 0.4 1.2 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain ASC PF00858.24 AIC16105.1 - 0.26 10.2 0.2 0.57 9.1 0.0 1.6 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel CENP-I PF07778.11 AIC16105.1 - 0.33 9.6 2.4 0.44 9.2 2.4 1.1 1 0 0 1 1 1 0 Mis6 Polysacc_synt_C PF14667.6 AIC16105.1 - 1.1 9.3 9.6 1.4 8.9 4.8 2.3 3 0 0 3 3 3 0 Polysaccharide biosynthesis C-terminal domain Pyr_redox_2 PF07992.14 AIC16106.1 - 3.3e-25 88.9 0.0 7.8e-25 87.7 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 AIC16106.1 - 5.2e-06 26.9 0.1 0.0091 16.5 0.1 2.6 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 AIC16106.1 - 0.00038 20.6 0.1 0.0009 19.4 0.1 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 AIC16106.1 - 0.0024 17.5 0.5 0.048 13.2 0.1 2.1 1 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 AIC16106.1 - 0.0044 16.2 0.1 0.041 12.9 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain NAD_binding_9 PF13454.6 AIC16106.1 - 0.017 15.1 0.1 0.18 11.8 0.1 2.3 2 0 0 2 2 2 0 FAD-NAD(P)-binding HI0933_like PF03486.14 AIC16106.1 - 0.041 12.6 0.1 0.24 10.0 0.1 2.0 2 0 0 2 2 2 0 HI0933-like protein Thi4 PF01946.17 AIC16106.1 - 0.11 11.7 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family Trp_halogenase PF04820.14 AIC16106.1 - 0.12 11.2 0.0 0.23 10.3 0.0 1.4 1 0 0 1 1 1 0 Tryptophan halogenase adh_short PF00106.25 AIC16108.1 - 6.8e-65 218.2 3.1 8.6e-65 217.9 3.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIC16108.1 - 2.4e-51 174.5 3.9 3e-51 174.2 3.9 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIC16108.1 - 3.1e-14 53.3 0.8 5.1e-14 52.6 0.8 1.2 1 0 0 1 1 1 1 KR domain DUF1776 PF08643.10 AIC16108.1 - 4e-05 23.1 0.0 5.3e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Epimerase PF01370.21 AIC16108.1 - 0.00053 19.5 0.6 0.0043 16.6 0.6 2.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 AIC16108.1 - 0.0046 16.9 2.1 0.0074 16.2 2.1 1.3 1 1 0 1 1 1 1 NAD(P)H-binding THF_DHG_CYH_C PF02882.19 AIC16108.1 - 0.011 15.1 2.2 0.028 13.7 0.2 2.5 2 1 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Eno-Rase_NADH_b PF12242.8 AIC16108.1 - 0.23 11.2 1.8 0.5 10.2 1.8 1.5 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase CTP_transf_1 PF01148.20 AIC16110.1 - 1.4e-05 25.0 9.3 8.6e-05 22.4 8.3 2.0 1 1 1 2 2 2 1 Cytidylyltransferase family RseC_MucC PF04246.12 AIC16110.1 - 0.045 13.7 1.3 10 6.1 0.0 2.5 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC ThrE PF06738.12 AIC16110.1 - 0.12 11.8 5.6 0.077 12.4 0.6 2.2 2 0 0 2 2 2 0 Putative threonine/serine exporter TfoX_N PF04993.13 AIC16111.1 - 0.0013 18.9 0.0 0.0016 18.6 0.0 1.1 1 0 0 1 1 1 1 TfoX N-terminal domain DUF4257 PF14074.6 AIC16112.1 - 0.12 12.5 6.3 0.83 9.9 2.2 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF4257) YqhR PF11085.8 AIC16112.1 - 0.12 12.2 8.6 3 7.8 8.4 2.2 1 1 0 1 1 1 0 Conserved membrane protein YqhR DUF1440 PF07274.12 AIC16112.1 - 0.21 11.9 5.9 0.32 11.3 5.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1440) DUF3042 PF11240.8 AIC16113.1 - 0.023 14.7 0.5 0.28 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) RseC_MucC PF04246.12 AIC16113.1 - 0.044 13.7 1.6 0.05 13.6 1.6 1.1 1 0 0 1 1 1 0 Positive regulator of sigma(E), RseC/MucC VGCC_beta4Aa_N PF12052.8 AIC16114.1 - 0.01 15.9 0.2 0.19 11.8 0.0 2.6 3 0 0 3 3 3 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal Gln-synt_C PF00120.24 AIC16115.1 - 4.5e-117 390.9 0.0 5.4e-117 390.6 0.0 1.1 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 AIC16115.1 - 1.2e-24 85.9 0.0 2.8e-24 84.6 0.0 1.7 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain AA_synth PF06684.11 AIC16115.1 - 0.066 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Amino acid synthesis Rotamase_3 PF13616.6 AIC16118.1 - 8.6e-28 97.2 0.0 1.4e-27 96.6 0.0 1.3 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase PF00639.21 AIC16118.1 - 1.5e-24 86.7 0.0 1.8e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 AIC16118.1 - 2.8e-09 37.9 0.0 3.2e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain NTPase_I-T PF01931.18 AIC16118.1 - 0.02 14.7 0.0 0.028 14.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF84 Get5_C PF18514.1 AIC16118.1 - 0.062 13.0 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Get5 C-terminal domain Cupredoxin_1 PF13473.6 AIC16119.1 - 4.7e-07 29.9 0.0 3.4e-06 27.1 0.0 2.3 2 0 0 2 2 2 1 Cupredoxin-like domain Copper-bind PF00127.20 AIC16119.1 - 0.00055 20.3 0.0 0.0018 18.7 0.0 1.9 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family MG2 PF01835.19 AIC16119.1 - 0.0053 17.2 0.0 0.066 13.7 0.0 2.7 3 0 0 3 3 3 1 MG2 domain SIMPL PF04402.14 AIC16121.1 - 7.4e-43 147.3 9.2 9.6e-43 147.0 9.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF541) DUF1657 PF07870.11 AIC16121.1 - 0.0043 16.9 0.9 0.0087 15.9 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1657) VIR_N PF15912.5 AIC16121.1 - 0.038 13.6 1.3 0.053 13.1 1.3 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal NAD_binding_10 PF13460.6 AIC16121.1 - 0.044 13.7 1.3 2 8.3 0.3 2.2 2 0 0 2 2 2 0 NAD(P)H-binding PRIMA1 PF16101.5 AIC16121.1 - 0.075 13.1 3.1 0.16 12.0 3.1 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 AIC16121.1 - 0.14 12.2 0.4 0.23 11.5 0.4 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator HD_4 PF13328.6 AIC16122.1 - 2.4e-18 66.3 7.3 3.1e-18 66.0 7.3 1.1 1 0 0 1 1 1 1 HD domain HD PF01966.22 AIC16122.1 - 3.1e-07 30.6 2.6 6e-07 29.7 1.0 2.1 2 0 0 2 2 2 1 HD domain DnaJ PF00226.31 AIC16124.1 - 1.5e-24 85.9 1.2 2.9e-24 84.9 1.2 1.5 1 0 0 1 1 1 1 DnaJ domain Fer4_13 PF13370.6 AIC16124.1 - 2.2e-07 31.3 0.2 2.2e-07 31.3 0.2 1.9 2 0 0 2 2 2 1 4Fe-4S single cluster domain of Ferredoxin I Fer4_15 PF13459.6 AIC16124.1 - 1.2e-05 26.0 0.4 4.1e-05 24.2 0.4 2.0 1 1 0 1 1 1 1 4Fe-4S single cluster domain Fer4_19 PF06902.11 AIC16124.1 - 6.8e-05 22.9 0.1 0.00014 21.8 0.1 1.6 1 0 0 1 1 1 1 Divergent 4Fe-4S mono-cluster OrfB_IS605 PF01385.19 AIC16125.1 - 3.1e-20 72.6 1.0 3.1e-20 72.6 1.0 2.0 2 0 0 2 2 2 1 Probable transposase OrfB_Zn_ribbon PF07282.11 AIC16125.1 - 6.4e-13 48.4 1.1 1.9e-12 46.9 1.1 1.8 1 0 0 1 1 1 1 Putative transposase DNA-binding domain HTH_OrfB_IS605 PF12323.8 AIC16125.1 - 3.7e-12 45.5 0.1 1.4e-11 43.7 0.1 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain zf-ribbon_3 PF13248.6 AIC16125.1 - 0.0076 15.6 1.8 0.031 13.7 0.1 2.6 2 0 0 2 2 2 1 zinc-ribbon domain DZR PF12773.7 AIC16125.1 - 0.015 15.3 0.4 0.037 14.0 0.4 1.6 1 0 0 1 1 1 0 Double zinc ribbon HypA PF01155.19 AIC16125.1 - 0.021 14.8 0.2 0.021 14.8 0.2 1.8 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_10 PF18414.1 AIC16125.1 - 0.056 13.0 0.1 0.16 11.5 0.1 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger Acetyltransf_13 PF13880.6 AIC16125.1 - 0.092 12.7 0.0 0.36 10.8 0.0 2.0 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase zf-ACC PF17848.1 AIC16125.1 - 0.15 12.1 2.8 8.1 6.6 0.1 3.2 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain FYVE PF01363.21 AIC16125.1 - 0.24 11.5 0.2 0.24 11.5 0.2 2.2 2 1 0 2 2 2 0 FYVE zinc finger zf_UBZ PF18439.1 AIC16125.1 - 1.9 8.2 7.1 1.2 8.8 0.3 2.6 2 1 1 3 3 3 0 Ubiquitin-Binding Zinc Finger TP_methylase PF00590.20 AIC16126.1 - 3.7e-52 177.4 0.2 4.5e-52 177.1 0.2 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Radical_SAM PF04055.21 AIC16126.1 - 0.093 13.1 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Radical SAM superfamily TP_methylase PF00590.20 AIC16127.1 - 1.5e-45 155.8 0.8 2.1e-45 155.3 0.8 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DUF826 PF05696.11 AIC16128.1 - 0.02 14.9 0.1 0.038 14.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF826) E1_FCCH PF16190.5 AIC16128.1 - 0.21 11.8 0.0 0.3 11.3 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin-activating enzyme E1 FCCH domain SPC12 PF06645.13 AIC16130.1 - 4.3 7.5 9.5 9.1 6.4 0.5 2.2 1 1 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) Snf7 PF03357.21 AIC16131.1 - 0.002 17.7 1.7 0.002 17.7 1.7 1.5 2 0 0 2 2 2 1 Snf7 KASH_CCD PF14662.6 AIC16131.1 - 0.048 13.5 1.6 0.081 12.7 1.6 1.3 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DASH_Duo1 PF08651.10 AIC16131.1 - 0.07 12.9 0.9 0.18 11.6 0.1 2.1 2 0 0 2 2 2 0 DASH complex subunit Duo1 CtsR PF05848.11 AIC16135.1 - 0.13 12.2 0.1 0.27 11.2 0.1 1.5 1 0 0 1 1 1 0 CtsR N-terminal HTH domain Phage_GP20 PF06810.11 AIC16137.1 - 0.23 11.3 0.0 0.23 11.3 0.0 1.0 1 0 0 1 1 1 0 Phage minor structural protein GP20 Polysacc_deac_1 PF01522.21 AIC16138.1 - 1.3e-11 44.5 0.0 2.4e-11 43.6 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase Big_7 PF17957.1 AIC16138.1 - 2.3e-05 25.1 3.1 3.9e-05 24.3 2.2 1.8 1 1 0 1 1 1 1 Bacterial Ig domain Asp_Glu_race PF01177.22 AIC16141.1 - 2e-21 76.9 0.0 2.6e-21 76.5 0.0 1.2 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase rve_3 PF13683.6 AIC16142.1 - 1.3e-05 24.9 0.0 1.8e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain DUF2384 PF09722.10 AIC16142.1 - 0.075 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2384) rve_3 PF13683.6 AIC16144.1 - 3.3e-08 33.2 0.1 6.2e-08 32.3 0.1 1.5 1 1 0 1 1 1 1 Integrase core domain DDE_Tnp_IS240 PF13610.6 AIC16144.1 - 0.00025 21.3 0.2 0.0003 21.0 0.2 1.2 1 0 0 1 1 1 1 DDE domain rve PF00665.26 AIC16144.1 - 0.072 13.3 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Integrase core domain 7TMR-DISM_7TM PF07695.11 AIC16145.1 - 0.07 13.0 10.1 0.11 12.4 10.1 1.3 1 0 0 1 1 1 0 7TM diverse intracellular signalling DUF3784 PF12650.7 AIC16145.1 - 0.078 13.2 4.1 2.7 8.3 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Prenyltransf PF01255.19 AIC16148.1 - 1e-68 231.2 0.4 1.2e-68 231.0 0.4 1.0 1 0 0 1 1 1 1 Putative undecaprenyl diphosphate synthase Adenine_glyco PF03352.13 AIC16148.1 - 0.029 14.1 0.2 0.049 13.4 0.2 1.3 1 0 0 1 1 1 0 Methyladenine glycosylase MHC2-interact PF09307.10 AIC16149.1 - 1.4 8.9 3.8 11 6.0 0.1 3.0 2 1 1 3 3 3 0 CLIP, MHC2 interacting PPP4R2 PF09184.11 AIC16149.1 - 2.3 7.8 15.0 4 6.9 15.0 1.4 1 0 0 1 1 1 0 PPP4R2 BUD22 PF09073.10 AIC16149.1 - 2.7 7.2 20.8 3.8 6.8 20.8 1.2 1 0 0 1 1 1 0 BUD22 zinc_ribbon_2 PF13240.6 AIC16151.1 - 1.3e-07 31.1 3.5 2.1e-07 30.4 3.5 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIC16151.1 - 0.00013 21.9 2.7 0.00023 21.1 2.7 1.4 1 0 0 1 1 1 1 Double zinc ribbon zinc_ribbon_15 PF17032.5 AIC16151.1 - 0.00022 21.9 0.1 0.00042 21.0 0.1 1.5 1 0 0 1 1 1 1 zinc-ribbon family ASFV_p27 PF06556.11 AIC16151.1 - 0.00033 20.8 0.4 0.00065 19.8 0.2 1.5 2 0 0 2 2 2 1 IAP-like protein p27 C-terminus zf-ribbon_3 PF13248.6 AIC16151.1 - 0.00041 19.6 2.8 0.0007 18.9 2.8 1.4 1 0 0 1 1 1 1 zinc-ribbon domain UPF0547 PF10571.9 AIC16151.1 - 0.0098 16.0 4.0 0.017 15.2 4.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein family UPF0547 DUF2116 PF09889.9 AIC16151.1 - 0.059 13.4 1.4 0.11 12.5 1.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DHHC PF01529.20 AIC16151.1 - 0.06 13.4 1.1 0.11 12.6 1.1 1.4 1 0 0 1 1 1 0 DHHC palmitoyltransferase zf-RRN7 PF11781.8 AIC16151.1 - 0.14 11.8 2.9 1.1 9.1 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 Nudix_N_2 PF14803.6 AIC16151.1 - 0.27 11.2 5.2 3.5 7.6 1.1 2.5 2 0 0 2 2 2 0 Nudix N-terminal YhfH PF14149.6 AIC16151.1 - 0.73 9.9 3.8 2.6 8.1 0.2 2.2 1 1 1 2 2 2 0 YhfH-like protein DUF4149 PF13664.6 AIC16152.1 - 0.043 14.1 1.1 0.043 14.1 1.1 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) Na_H_Exchanger PF00999.21 AIC16155.1 - 4.1e-54 183.8 50.9 5.1e-54 183.5 50.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Spore_YabQ PF09578.10 AIC16155.1 - 0.14 12.4 0.3 0.14 12.4 0.3 3.8 3 2 0 4 4 4 0 Spore cortex protein YabQ (Spore_YabQ) UPF0542 PF15086.6 AIC16155.1 - 0.38 10.7 0.1 0.38 10.7 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 Asp-Al_Ex PF06826.12 AIC16155.1 - 8.9 6.1 38.8 3.2 7.5 12.5 3.7 2 2 1 3 3 3 0 Predicted Permease Membrane Region Glyco_hydro_14 PF01373.17 AIC16156.1 - 0.1 11.5 0.1 0.13 11.1 0.1 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 ADH_zinc_N PF00107.26 AIC16157.1 - 4.8e-29 101.0 0.3 7.2e-29 100.4 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIC16157.1 - 4.1e-24 84.6 0.0 7e-24 83.8 0.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AIC16157.1 - 3.2e-16 60.6 0.0 5.8e-16 59.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TrkA_N PF02254.18 AIC16157.1 - 0.081 13.2 0.0 0.33 11.2 0.0 2.0 2 0 0 2 2 2 0 TrkA-N domain Methyltransf_16 PF10294.9 AIC16157.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.2 1 0 0 1 1 1 0 Lysine methyltransferase DUF2689 PF10894.8 AIC16158.1 - 0.048 13.4 0.0 0.26 11.1 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2689) CopG_antitoxin PF12441.8 AIC16159.1 - 0.00014 22.4 0.1 0.00038 20.9 0.0 1.8 2 0 0 2 2 2 1 CopG antitoxin of type II toxin-antitoxin system TerC PF03741.16 AIC16160.1 - 1.6e-50 171.3 16.7 1.6e-50 171.3 16.7 2.1 2 0 0 2 2 2 1 Integral membrane protein TerC family zf-Di19 PF05605.12 AIC16161.1 - 6.8e-05 23.1 0.1 7.9e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 AIC16161.1 - 0.00017 22.1 0.3 0.00022 21.8 0.3 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC16161.1 - 0.0003 21.1 0.8 0.00036 20.8 0.8 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_9 PF16293.5 AIC16161.1 - 0.0012 18.6 0.1 0.0014 18.4 0.1 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 AIC16161.1 - 0.0017 18.6 0.1 0.0017 18.6 0.1 1.0 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-H2C2_2 PF13465.6 AIC16161.1 - 0.013 15.9 3.9 0.89 10.1 0.4 2.1 2 0 0 2 2 2 0 Zinc-finger double domain TRAF6_Z2 PF18048.1 AIC16161.1 - 0.017 15.2 0.0 0.021 14.9 0.0 1.2 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 DUF2225 PF09986.9 AIC16161.1 - 0.017 14.8 0.0 0.017 14.8 0.0 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-C2H2_11 PF16622.5 AIC16161.1 - 0.037 13.8 0.2 0.043 13.6 0.2 1.2 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-CHCC PF10276.9 AIC16161.1 - 0.062 13.4 0.2 0.08 13.0 0.2 1.2 1 0 0 1 1 1 0 Zinc-finger domain Rad50_zn_hook PF04423.14 AIC16161.1 - 0.069 13.0 0.1 0.089 12.6 0.1 1.2 1 0 0 1 1 1 0 Rad50 zinc hook motif Adenine_glyco PF03352.13 AIC16162.1 - 0.022 14.5 0.0 0.032 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyladenine glycosylase DUF2555 PF10742.9 AIC16162.1 - 0.024 14.4 0.1 0.049 13.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) DUF72 PF01904.18 AIC16164.1 - 0.00027 21.1 0.2 0.00029 21.0 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 PepSY PF03413.19 AIC16166.1 - 1.3e-10 41.7 3.5 6.8e-06 26.5 0.5 2.2 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain Transposase_31 PF04754.12 AIC16166.1 - 0.0043 16.7 0.1 0.0083 15.7 0.0 1.4 2 0 0 2 2 2 1 Putative transposase, YhgA-like NEAT PF05031.12 AIC16166.1 - 0.075 13.6 1.5 0.52 10.9 0.1 2.1 1 1 1 2 2 2 0 Iron Transport-associated domain Flagellin_D3 PF08884.11 AIC16166.1 - 2.1 8.8 7.4 1.3 9.5 2.5 2.6 1 1 1 2 2 2 0 Flagellin D3 domain zinc_ribbon_9 PF14369.6 AIC16168.1 - 0.01 16.0 1.8 0.011 16.0 0.5 1.7 2 0 0 2 2 2 0 zinc-ribbon DUF4242 PF14026.6 AIC16169.1 - 4.5e-10 39.6 0.0 5.3e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4242) RE_Eco47II PF09553.10 AIC16169.1 - 0.041 13.5 0.0 0.043 13.4 0.0 1.2 1 0 0 1 1 1 0 Eco47II restriction endonuclease AmoC PF04896.12 AIC16170.1 - 3e-14 52.9 6.2 3.8e-14 52.5 6.2 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C RTA1 PF04479.13 AIC16170.1 - 0.0053 16.4 0.2 0.0085 15.7 0.2 1.2 1 0 0 1 1 1 1 RTA1 like protein HicB PF05534.12 AIC16171.1 - 0.0019 18.0 0.1 0.0035 17.1 0.1 1.4 1 0 0 1 1 1 1 HicB family HTH_20 PF12840.7 AIC16172.1 - 1.5e-10 40.9 0.4 3.4e-10 39.8 0.3 1.6 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.20 AIC16172.1 - 3e-07 30.2 0.3 5.4e-07 29.4 0.3 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIC16172.1 - 2.8e-05 23.6 0.0 5.8e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR_2 PF12802.7 AIC16172.1 - 0.00012 21.9 0.3 0.00021 21.1 0.3 1.4 1 0 0 1 1 1 1 MarR family HTH_Crp_2 PF13545.6 AIC16172.1 - 0.0007 19.5 0.6 0.0017 18.3 0.3 1.8 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain DprA_WH PF17782.1 AIC16172.1 - 0.013 15.6 0.1 0.028 14.5 0.1 1.6 1 0 0 1 1 1 0 DprA winged helix domain TrmB PF01978.19 AIC16172.1 - 0.052 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Sigma70_r4 PF04545.16 AIC16172.1 - 0.054 13.0 0.2 0.73 9.4 0.0 2.7 3 0 0 3 3 3 0 Sigma-70, region 4 CUT PF02376.15 AIC16172.1 - 0.055 13.6 0.1 4.1 7.6 0.0 2.8 3 0 0 3 3 3 0 CUT domain V4R PF02830.18 AIC16174.1 - 1.7e-09 37.5 1.8 2.9e-09 36.8 1.8 1.4 1 0 0 1 1 1 1 V4R domain RHH_1 PF01402.21 AIC16175.1 - 0.002 18.0 0.2 0.0071 16.2 0.2 2.0 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family CopG_antitoxin PF12441.8 AIC16175.1 - 0.01 16.4 0.1 0.054 14.0 0.0 2.1 2 0 0 2 2 2 0 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIC16175.1 - 0.037 13.9 0.0 0.086 12.7 0.0 1.6 1 0 0 1 1 1 0 HicB family RHH_3 PF12651.7 AIC16175.1 - 0.058 13.4 0.2 0.11 12.5 0.2 1.5 1 0 0 1 1 1 0 Ribbon-helix-helix domain HisKA_3 PF07730.13 AIC16177.1 - 0.0015 19.0 8.8 0.17 12.4 0.0 4.0 1 1 2 3 3 3 2 Histidine kinase Collagen_mid PF15984.5 AIC16177.1 - 0.067 12.9 0.4 0.11 12.2 0.2 1.3 1 1 0 1 1 1 0 Bacterial collagen, middle region DUF5309 PF17236.2 AIC16177.1 - 0.22 10.8 13.8 0.28 10.5 13.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5309) DUF4141 PF13605.6 AIC16177.1 - 0.44 9.8 1.5 26 4.1 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4141) OMS28_porin PF03532.13 AIC16177.1 - 0.45 9.7 13.1 0.57 9.4 13.1 1.1 1 0 0 1 1 1 0 OMS28 porin DUF948 PF06103.11 AIC16177.1 - 2.3 8.5 11.6 2e+03 -0.9 11.5 3.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF4776 PF16003.5 AIC16177.1 - 2.7 6.9 17.8 3.5 6.5 17.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) DUF4854 PF16146.5 AIC16177.1 - 3.3 8.1 10.2 8.4 6.8 3.9 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4854) Merozoite_SPAM PF07133.11 AIC16177.1 - 5.1 7.0 10.6 0.72 9.8 6.1 1.6 1 1 1 2 2 2 0 Merozoite surface protein (SPAM) GAGA_bind PF06217.12 AIC16177.1 - 7.5 6.8 16.2 9.6 6.4 16.2 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4131 PF13567.6 AIC16178.1 - 0.027 14.1 0.2 0.034 13.8 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4282 PF14110.6 AIC16178.1 - 0.032 15.0 1.7 0.038 14.7 1.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4282) SbmA_BacA PF05992.12 AIC16178.1 - 0.075 12.5 0.7 0.079 12.4 0.7 1.0 1 0 0 1 1 1 0 SbmA/BacA-like family DUF2207 PF09972.9 AIC16178.1 - 0.94 8.2 3.3 1.1 8.0 3.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LIM PF00412.22 AIC16180.1 - 8.9e-06 25.8 1.9 1.7e-05 25.0 1.9 1.5 1 1 0 1 1 1 1 LIM domain zf-dskA_traR PF01258.17 AIC16180.1 - 0.0058 16.5 4.9 4 7.5 0.0 3.1 3 0 0 3 3 3 2 Prokaryotic dksA/traR C4-type zinc finger Zf_RING PF16744.5 AIC16180.1 - 0.013 15.6 0.9 0.013 15.6 0.9 1.8 1 1 1 2 2 2 0 KIAA1045 RING finger zf-HC5HC2H_2 PF13832.6 AIC16180.1 - 0.053 13.7 3.7 0.088 13.0 3.7 1.4 1 1 0 1 1 1 0 PHD-zinc-finger like domain zinc_ribbon_2 PF13240.6 AIC16180.1 - 0.36 10.6 7.2 1.9 8.3 0.2 3.1 3 0 0 3 3 3 0 zinc-ribbon domain zf-C3H2C3 PF17122.5 AIC16180.1 - 0.45 10.6 5.8 2.1 8.5 2.7 2.8 2 1 1 3 3 3 0 Zinc-finger Vps39_2 PF10367.9 AIC16180.1 - 0.48 10.9 2.5 1.3 9.5 0.1 2.1 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 DUF35_N PF12172.8 AIC16180.1 - 0.66 9.9 4.6 13 5.8 0.1 2.8 3 0 0 3 3 3 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf-ribbon_3 PF13248.6 AIC16180.1 - 0.66 9.5 7.3 4.6 6.8 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain C1_1 PF00130.22 AIC16180.1 - 0.73 9.8 8.0 0.78 9.7 2.2 2.6 1 1 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) TF_Zn_Ribbon PF08271.12 AIC16180.1 - 1.1 8.9 5.9 7.7 6.1 0.1 2.7 3 0 0 3 3 3 0 TFIIB zinc-binding SpoIID PF08486.10 AIC16181.1 - 0.17 12.5 0.0 0.22 12.1 0.0 1.3 1 1 0 1 1 1 0 Stage II sporulation protein CopG_antitoxin PF12441.8 AIC16183.1 - 0.0005 20.5 0.1 0.0011 19.4 0.1 1.6 1 0 0 1 1 1 1 CopG antitoxin of type II toxin-antitoxin system HicB PF05534.12 AIC16183.1 - 0.0023 17.7 0.0 0.0043 16.9 0.0 1.5 1 0 0 1 1 1 1 HicB family Rxt3 PF08642.10 AIC16183.1 - 0.0044 17.8 0.1 0.0077 17.0 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylation protein Rxt3 Arc PF03869.14 AIC16183.1 - 0.0096 15.7 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 Arc-like DNA binding domain DUF892 PF05974.12 AIC16183.1 - 0.0097 15.9 0.7 0.2 11.7 0.2 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF892) baeRF_family12 PF18856.1 AIC16183.1 - 0.11 13.1 0.7 0.24 12.0 0.7 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 Cu-oxidase_3 PF07732.15 AIC16184.1 - 1.3e-24 86.5 5.1 5.1e-23 81.3 0.1 3.2 3 1 0 3 3 3 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIC16184.1 - 4.2e-16 58.9 10.8 8.3e-09 35.3 1.6 4.0 3 1 0 3 3 3 2 Multicopper oxidase Cupredoxin_1 PF13473.6 AIC16184.1 - 8.6e-13 48.3 0.0 2e-09 37.5 0.1 3.4 4 0 0 4 4 4 2 Cupredoxin-like domain Copper-bind PF00127.20 AIC16184.1 - 1.2e-11 44.9 5.0 2.9e-08 34.1 0.6 3.6 2 1 1 3 3 3 2 Copper binding proteins, plastocyanin/azurin family Cu-oxidase PF00394.22 AIC16184.1 - 0.0089 16.2 0.2 0.86 9.7 0.0 3.1 3 0 0 3 3 3 1 Multicopper oxidase MSA-2c PF12238.8 AIC16184.1 - 0.03 14.3 0.4 0.049 13.6 0.4 1.4 1 0 0 1 1 1 0 Merozoite surface antigen 2c TMEM70 PF06979.12 AIC16185.1 - 0.1 13.0 0.3 0.35 11.3 0.0 1.9 2 0 0 2 2 2 0 Assembly, mitochondrial proton-transport ATP synth complex MscS_TM PF12794.7 AIC16185.1 - 0.11 11.3 0.1 0.17 10.7 0.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 NOB1_Zn_bind PF08772.11 AIC16186.1 - 0.065 13.4 0.4 0.098 12.8 0.4 1.3 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like CpXC PF14353.6 AIC16186.1 - 0.095 12.8 0.1 0.16 12.0 0.0 1.5 2 0 0 2 2 2 0 CpXC protein DUF3306 PF11748.8 AIC16186.1 - 0.095 13.6 0.9 0.15 12.9 0.0 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3306) zinc_ribbon_10 PF10058.9 AIC16186.1 - 0.18 11.5 1.6 0.88 9.4 1.9 1.9 1 1 1 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein p450 PF00067.22 AIC16187.1 - 8.4e-35 120.4 0.1 1.8e-32 112.7 0.1 3.0 1 1 0 1 1 1 1 Cytochrome P450 Cdh1_DBD_1 PF18196.1 AIC16187.1 - 0.043 14.1 0.9 0.12 12.7 0.2 2.0 2 1 1 3 3 3 0 Chromodomain helicase DNA-binding domain 1 Fer4_7 PF12838.7 AIC16189.1 - 1e-09 38.8 2.8 0.00017 22.1 0.8 2.4 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 AIC16189.1 - 1.9e-09 37.0 12.2 2.3e-06 27.2 1.5 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 AIC16189.1 - 5.2e-08 32.9 6.9 2.8e-06 27.4 7.4 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIC16189.1 - 2.4e-07 30.8 2.7 0.0016 18.5 0.4 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_9 PF13187.6 AIC16189.1 - 4.6e-07 29.9 7.3 1.4e-06 28.4 7.3 1.7 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIC16189.1 - 1.1e-06 29.5 5.6 0.0016 19.3 0.7 2.5 3 0 0 3 3 2 2 4Fe-4S double cluster binding domain Fer4_6 PF12837.7 AIC16189.1 - 7.6e-06 25.8 12.5 0.0055 16.7 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_8 PF13183.6 AIC16189.1 - 8.9e-06 26.1 6.9 0.001 19.5 8.4 2.4 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIC16189.1 - 1.1e-05 25.9 4.6 7.6e-05 23.2 5.3 1.9 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_13 PF13370.6 AIC16189.1 - 7e-05 23.3 8.6 0.017 15.7 0.5 2.7 3 0 0 3 3 3 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_2 PF12797.7 AIC16189.1 - 0.00028 20.8 10.6 0.055 13.6 3.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 AIC16189.1 - 0.00037 20.8 6.2 0.039 14.5 1.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIC16189.1 - 0.0011 19.6 8.5 0.11 13.2 3.0 3.0 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_18 PF13746.6 AIC16189.1 - 0.0025 18.0 7.5 0.0039 17.4 5.5 2.1 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_22 PF17179.4 AIC16189.1 - 0.0062 17.4 0.3 5.6 7.9 0.0 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIC16189.1 - 0.029 15.3 13.9 1.4 10.0 0.8 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain NapD PF03927.13 AIC16191.1 - 1.5e-05 25.0 0.0 1.6e-05 24.9 0.0 1.0 1 0 0 1 1 1 1 NapD protein AsnC_trans_reg PF01037.21 AIC16191.1 - 1.5e-05 24.9 0.0 1.5e-05 24.8 0.0 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain AsnC_trans_reg2 PF17805.1 AIC16191.1 - 0.085 13.0 0.0 0.091 12.9 0.0 1.1 1 0 0 1 1 1 0 AsnC-like ligand binding domain zinc_ribbon_12 PF11331.8 AIC16193.1 - 0.33 10.8 0.1 0.33 10.8 0.1 3.4 3 1 0 3 3 3 0 Probable zinc-ribbon domain Ribosomal_L37e PF01907.19 AIC16193.1 - 0.47 10.7 15.8 0.15 12.3 1.6 2.3 1 1 1 2 2 2 0 Ribosomal protein L37e DUF2797 PF10977.8 AIC16193.1 - 0.51 10.2 10.9 0.1 12.5 3.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2797) zf-C2H2_4 PF13894.6 AIC16193.1 - 1 10.4 0.1 1 10.4 0.1 3.4 3 1 1 4 4 4 0 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC16193.1 - 3.9 8.1 0.0 3.9 8.1 0.0 3.5 3 1 0 3 3 3 0 Zinc finger, C2H2 type Polyketide_cyc2 PF10604.9 AIC16196.1 - 1.5e-11 44.7 0.0 1.7e-11 44.6 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIC16196.1 - 1.9e-05 24.9 0.0 3.6e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport RCC_reductase PF06405.11 AIC16197.1 - 0.11 11.7 0.0 0.14 11.3 0.0 1.1 1 0 0 1 1 1 0 Red chlorophyll catabolite reductase (RCC reductase) NitrOD2 PF18550.1 AIC16199.1 - 0.00012 22.2 0.0 0.00012 22.2 0.0 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 HTH_45 PF14947.6 AIC16201.1 - 1.1e-16 60.5 0.4 1.5e-16 60.1 0.4 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DnaI_N PF07319.11 AIC16203.1 - 0.0035 18.0 0.1 0.0042 17.7 0.1 1.1 1 0 0 1 1 1 1 Primosomal protein DnaI N-terminus DHHW PF14286.6 AIC16203.1 - 0.038 13.3 0.1 0.038 13.3 0.1 1.0 1 0 0 1 1 1 0 DHHW protein Peptidase_M13 PF01431.21 AIC16203.1 - 0.063 12.9 0.0 0.066 12.8 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M13 SEN1_N PF12726.7 AIC16203.1 - 0.081 11.1 0.0 0.097 10.9 0.0 1.0 1 0 0 1 1 1 0 SEN1 N terminal DUF2922 PF11148.8 AIC16204.1 - 0.0024 17.5 0.3 0.0064 16.2 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2922) CHB_HEX_C_1 PF13290.6 AIC16206.1 - 1.9e-31 107.9 47.9 8.1e-19 67.4 9.2 6.4 6 0 0 6 6 6 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIC16206.1 - 8.1e-25 86.8 33.2 3.9e-15 55.7 4.7 5.0 4 1 0 4 4 4 2 Fn3 associated Polysacc_deac_1 PF01522.21 AIC16206.1 - 9.6e-09 35.2 0.0 2.4e-08 33.9 0.0 1.7 1 0 0 1 1 1 1 Polysaccharide deacetylase HYR PF02494.16 AIC16206.1 - 5.2e-08 33.1 1.8 5.2e-08 33.1 1.8 5.4 4 2 2 6 6 6 1 HYR domain Y_Y_Y PF07495.13 AIC16206.1 - 4.6e-07 29.7 0.0 0.024 14.6 0.0 3.0 2 0 0 2 2 2 2 Y_Y_Y domain CHB_HEX_C PF03174.13 AIC16206.1 - 0.0002 21.3 0.2 0.14 12.2 0.0 2.8 2 0 0 2 2 2 2 Chitobiase/beta-hexosaminidase C-terminal domain ASH PF15780.5 AIC16206.1 - 0.01 16.0 0.0 0.041 14.1 0.0 2.0 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Rimk_N PF18030.1 AIC16206.1 - 0.061 13.7 0.0 0.17 12.3 0.0 1.7 1 0 0 1 1 1 0 RimK PreATP-grasp domain Glyco_hydro_2 PF00703.21 AIC16206.1 - 1.1 10.0 3.5 0.62 10.8 0.3 2.2 2 0 0 2 2 2 0 Glycosyl hydrolases family 2 PepSY PF03413.19 AIC16207.1 - 0.0047 17.5 0.1 0.0078 16.7 0.1 1.3 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain DUF2615 PF11027.8 AIC16207.1 - 0.02 15.0 0.2 0.035 14.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) SNARE_assoc PF09335.11 AIC16209.1 - 6e-17 62.3 1.8 6e-17 62.3 1.8 1.5 2 0 0 2 2 2 1 SNARE associated Golgi protein DUF4112 PF13430.6 AIC16209.1 - 0.31 11.3 2.1 0.88 9.9 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4112) HTH_45 PF14947.6 AIC16210.1 - 1.4e-19 69.8 0.3 1.6e-19 69.6 0.3 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC16210.1 - 0.051 13.3 0.3 0.072 12.8 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) ER PF01133.17 AIC16210.1 - 0.09 12.8 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Enhancer of rudimentary AsnC_trans_reg PF01037.21 AIC16211.1 - 2.8e-07 30.4 0.0 2.9e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIC16211.1 - 0.097 12.7 0.1 0.13 12.4 0.1 1.1 1 0 0 1 1 1 0 NapD protein Cpn60_TCP1 PF00118.24 AIC16213.1 - 0.0004 19.2 0.1 0.00049 18.9 0.1 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family eIF-1a PF01176.19 AIC16214.1 - 4.2e-20 71.3 0.8 5.4e-20 71.0 0.8 1.2 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.19 AIC16214.1 - 0.00049 19.9 0.6 0.0037 17.0 0.2 2.2 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain RsgA_N PF16745.5 AIC16214.1 - 0.0073 16.0 0.5 0.012 15.4 0.5 1.3 1 0 0 1 1 1 1 RsgA N-terminal domain Prot_ATP_ID_OB PF16450.5 AIC16214.1 - 0.023 14.6 0.0 0.032 14.2 0.0 1.2 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain GTP-bdg_N PF13167.6 AIC16215.1 - 2.4e-24 85.8 0.1 6.6e-24 84.4 0.1 1.7 1 0 0 1 1 1 1 GTP-binding GTPase N-terminal MMR_HSR1 PF01926.23 AIC16215.1 - 4.6e-18 65.4 0.2 1e-17 64.3 0.2 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP-bdg_M PF16360.5 AIC16215.1 - 2.7e-17 63.1 3.1 2.7e-17 63.1 3.1 1.7 2 0 0 2 2 1 1 GTP-binding GTPase Middle Region FeoB_N PF02421.18 AIC16215.1 - 7.7e-08 32.0 1.4 9.2e-08 31.8 0.3 1.8 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 AIC16215.1 - 8.4e-08 32.3 1.2 0.004 17.1 0.5 2.4 2 0 0 2 2 2 2 RsgA GTPase SRPRB PF09439.10 AIC16215.1 - 7.5e-05 22.2 0.5 0.00013 21.4 0.5 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 AIC16215.1 - 9.3e-05 22.0 0.5 0.0015 18.1 0.5 2.3 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 AIC16215.1 - 0.00015 22.3 0.7 0.0008 19.9 0.1 2.5 1 1 1 2 2 2 1 ABC transporter PduV-EutP PF10662.9 AIC16215.1 - 0.0005 19.8 0.8 0.0052 16.5 0.8 2.4 1 1 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 AIC16215.1 - 0.0023 18.0 1.7 0.011 15.8 1.7 2.1 1 1 0 1 1 1 1 Dynamin family cobW PF02492.19 AIC16215.1 - 0.0056 16.3 4.2 0.72 9.4 0.3 2.7 2 1 1 3 3 3 2 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 AIC16215.1 - 0.076 13.0 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Roc PF08477.13 AIC16215.1 - 0.079 13.2 0.5 0.43 10.8 0.5 2.3 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_33 PF13671.6 AIC16215.1 - 0.1 12.8 0.0 0.86 9.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 AIC16215.1 - 0.1 12.9 0.6 0.36 11.2 0.2 2.1 1 1 2 3 3 3 0 AAA ATPase domain zf-C2H2_6 PF13912.6 AIC16216.1 - 0.23 11.5 0.2 0.23 11.5 0.2 2.2 3 0 0 3 3 3 0 C2H2-type zinc finger TFIIB PF00382.19 AIC16217.1 - 2.4e-29 101.2 6.2 2.7e-14 52.9 0.3 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIC16217.1 - 7.5e-06 25.4 4.0 1.7e-05 24.2 4.0 1.6 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_11 PF08279.12 AIC16217.1 - 1.9e-05 24.5 1.2 0.00016 21.5 0.1 2.6 3 0 0 3 3 3 1 HTH domain HTH_AsnC-type PF13404.6 AIC16217.1 - 0.00086 19.1 0.0 0.0079 16.0 0.0 2.6 2 0 0 2 2 2 1 AsnC-type helix-turn-helix domain Cyclin_N PF00134.23 AIC16217.1 - 0.0019 17.9 0.4 0.66 9.7 0.1 2.2 2 0 0 2 2 2 2 Cyclin, N-terminal domain HTH_24 PF13412.6 AIC16217.1 - 0.0022 17.5 0.3 0.052 13.1 0.0 2.6 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding Sigma70_r4 PF04545.16 AIC16217.1 - 0.0056 16.2 0.0 0.17 11.4 0.0 2.6 2 1 0 2 2 2 1 Sigma-70, region 4 HTH_3 PF01381.22 AIC16217.1 - 0.0069 16.4 0.1 0.038 14.0 0.0 2.3 3 0 0 3 3 3 1 Helix-turn-helix RB_B PF01857.20 AIC16217.1 - 0.02 14.9 0.1 0.046 13.8 0.1 1.7 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain TetR_N PF00440.23 AIC16217.1 - 0.042 13.7 0.0 0.37 10.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family Rrf2 PF02082.20 AIC16217.1 - 0.042 14.2 1.4 2.4 8.5 0.0 2.9 3 0 0 3 3 3 0 Transcriptional regulator HARE-HTH PF05066.13 AIC16217.1 - 0.045 14.1 0.6 1.4 9.3 0.0 2.4 2 0 0 2 2 2 0 HB1, ASXL, restriction endonuclease HTH domain HTH_5 PF01022.20 AIC16217.1 - 0.057 13.3 0.0 1.2 9.0 0.1 2.8 2 0 0 2 2 2 0 Bacterial regulatory protein, arsR family HTH_Crp_2 PF13545.6 AIC16217.1 - 0.073 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Put_DNA-bind_N PF06971.13 AIC16217.1 - 0.075 13.1 0.1 0.61 10.1 0.0 2.5 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus HTH_23 PF13384.6 AIC16217.1 - 0.08 12.8 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 AIC16217.1 - 0.1 12.3 2.6 4 7.2 0.0 3.0 3 0 0 3 3 3 0 Sigma-70, region 4 HrcA_DNA-bdg PF03444.15 AIC16217.1 - 0.27 10.9 2.8 0.74 9.5 0.0 2.9 4 0 0 4 4 4 0 Winged helix-turn-helix transcription repressor, HrcA DNA-binding PKcGMP_CC PF16808.5 AIC16219.1 - 0.18 11.7 4.7 2.9 7.8 0.8 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase BLOC1_2 PF10046.9 AIC16221.1 - 0.001 19.3 1.4 0.0011 19.2 1.4 1.0 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Nup54 PF13874.6 AIC16221.1 - 0.0019 18.3 0.4 0.002 18.3 0.4 1.0 1 0 0 1 1 1 1 Nucleoporin complex subunit 54 DUF745 PF05335.13 AIC16221.1 - 0.0022 17.7 0.4 0.0023 17.7 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF745) COG6 PF06419.11 AIC16221.1 - 0.0042 15.4 0.8 0.0047 15.2 0.8 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 Seryl_tRNA_N PF02403.22 AIC16221.1 - 0.0055 16.9 1.4 0.0068 16.6 1.4 1.1 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain Lebercilin PF15619.6 AIC16221.1 - 0.007 16.0 2.7 0.0078 15.9 2.7 1.0 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Occludin_ELL PF07303.13 AIC16221.1 - 0.0076 17.0 0.7 0.0083 16.8 0.7 1.0 1 0 0 1 1 1 1 Occludin homology domain HWE_HK PF07536.14 AIC16221.1 - 0.0084 16.8 0.1 0.0098 16.6 0.1 1.1 1 0 0 1 1 1 1 HWE histidine kinase ECM11 PF15463.6 AIC16221.1 - 0.0088 16.6 0.4 0.01 16.4 0.4 1.1 1 0 0 1 1 1 1 Extracellular mutant protein 11 Laminin_II PF06009.12 AIC16221.1 - 0.017 15.1 0.9 0.02 14.9 0.9 1.0 1 0 0 1 1 1 0 Laminin Domain II DUF948 PF06103.11 AIC16221.1 - 0.018 15.3 0.2 0.021 15.0 0.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DASH_Dad3 PF08656.10 AIC16221.1 - 0.019 15.0 1.7 0.041 14.0 1.7 1.6 1 1 0 1 1 1 0 DASH complex subunit Dad3 TolA_bind_tri PF16331.5 AIC16221.1 - 0.029 14.4 0.8 0.039 14.0 0.8 1.3 1 1 0 1 1 1 0 TolA binding protein trimerisation DUF4988 PF16378.5 AIC16221.1 - 0.049 13.3 1.0 0.063 12.9 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function PspB PF06667.12 AIC16221.1 - 0.05 13.7 1.1 0.062 13.4 1.1 1.2 1 0 0 1 1 1 0 Phage shock protein B MCPsignal PF00015.21 AIC16221.1 - 0.051 13.4 0.1 0.056 13.2 0.1 1.0 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Hpt PF01627.23 AIC16221.1 - 0.074 13.3 0.1 0.13 12.5 0.1 1.5 1 1 0 1 1 1 0 Hpt domain DUF1664 PF07889.12 AIC16221.1 - 0.13 12.3 0.9 0.15 12.1 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) XhlA PF10779.9 AIC16221.1 - 0.26 11.5 4.4 0.56 10.5 3.7 1.8 1 1 1 2 2 2 0 Haemolysin XhlA FlaC_arch PF05377.11 AIC16221.1 - 0.36 11.3 3.7 0.48 10.9 2.0 1.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) PV_NSP1 PF12433.8 AIC16223.1 - 0.13 12.6 0.1 0.13 12.6 0.1 1.0 1 0 0 1 1 1 0 Parvovirus non-structural protein 1 Guanylate_cyc PF00211.20 AIC16225.1 - 2.7e-17 63.0 0.1 3.2e-16 59.5 0.1 2.1 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PGK PF00162.19 AIC16225.1 - 0.0034 16.4 0.1 0.0052 15.8 0.1 1.2 1 0 0 1 1 1 1 Phosphoglycerate kinase Terminase_5 PF06056.12 AIC16225.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) Radical_SAM PF04055.21 AIC16226.1 - 9.9e-10 39.0 0.2 5.2e-09 36.7 0.1 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 AIC16226.1 - 3.2e-06 27.4 0.1 6.2e-06 26.5 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIC16226.1 - 0.00013 22.1 0.2 0.00038 20.6 0.1 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain YgbA_NO PF11756.8 AIC16226.1 - 0.18 12.1 0.9 17 5.8 0.2 2.5 2 0 0 2 2 2 0 Nitrous oxide-stimulated promoter DUF4738 PF15889.5 AIC16227.1 - 0.047 13.5 0.1 0.047 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4738) GCR1_C PF12550.8 AIC16228.1 - 0.07 13.5 1.0 0.12 12.8 1.0 1.4 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes AAA PF00004.29 AIC16229.1 - 9.2e-98 323.8 0.0 3.2e-49 166.7 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 AIC16229.1 - 2e-26 92.0 0.2 6.6e-26 90.3 0.2 2.0 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 AIC16229.1 - 6.3e-25 86.7 0.8 3.2e-13 49.2 0.1 2.8 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 AIC16229.1 - 1.4e-17 63.9 0.0 6.3e-11 42.3 0.0 3.2 3 1 0 3 3 3 2 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 AIC16229.1 - 1.7e-16 60.8 0.0 6.5e-07 29.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AIC16229.1 - 3.2e-14 53.7 0.3 8.7e-05 23.0 0.0 4.0 2 2 1 3 3 3 2 AAA ATPase domain AAA_5 PF07728.14 AIC16229.1 - 1.1e-12 48.1 1.0 4.1e-06 26.9 0.1 4.2 4 2 0 4 4 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 AIC16229.1 - 2.1e-10 41.0 0.8 0.0059 16.9 0.1 4.1 2 2 2 4 4 4 2 AAA domain AAA_14 PF13173.6 AIC16229.1 - 1.2e-09 38.3 0.0 0.00057 19.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain TIP49 PF06068.13 AIC16229.1 - 1.6e-09 37.4 0.2 0.00088 18.6 0.1 2.5 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_33 PF13671.6 AIC16229.1 - 1.9e-08 34.6 0.0 0.0052 16.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 AIC16229.1 - 2.5e-07 31.0 0.0 0.019 15.4 0.0 2.6 2 0 0 2 2 2 2 RNA helicase Sigma54_activat PF00158.26 AIC16229.1 - 2.7e-07 30.4 0.1 0.097 12.4 0.1 3.8 3 1 0 3 3 3 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 AIC16229.1 - 2.7e-07 30.5 0.0 0.012 15.4 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein CDC48_2 PF02933.17 AIC16229.1 - 6e-07 29.2 0.1 1.8e-06 27.6 0.1 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_24 PF13479.6 AIC16229.1 - 1.7e-06 27.9 0.3 0.056 13.2 0.0 2.7 2 1 0 2 2 2 2 AAA domain ATPase PF06745.13 AIC16229.1 - 1.9e-06 27.4 0.3 0.19 11.1 0.0 3.5 3 0 0 3 3 3 2 KaiC AAA_18 PF13238.6 AIC16229.1 - 2.3e-06 28.2 0.0 0.061 13.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain Bac_DnaA PF00308.18 AIC16229.1 - 4.7e-06 26.6 0.1 0.073 12.9 0.0 3.6 2 2 1 3 3 3 2 Bacterial dnaA protein ATPase_2 PF01637.18 AIC16229.1 - 5.1e-06 26.6 0.0 0.022 14.7 0.0 3.1 2 1 0 3 3 3 2 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 AIC16229.1 - 7.8e-06 25.4 0.4 0.058 12.8 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_7 PF12775.7 AIC16229.1 - 8.3e-06 25.4 0.1 0.067 12.7 0.0 2.7 2 1 0 2 2 2 2 P-loop containing dynein motor region TsaE PF02367.17 AIC16229.1 - 1.4e-05 25.0 0.1 0.22 11.5 0.1 2.6 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 AIC16229.1 - 2e-05 24.9 0.0 0.28 11.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain PhoH PF02562.16 AIC16229.1 - 3.2e-05 23.5 0.6 0.15 11.5 0.1 2.6 2 0 0 2 2 2 2 PhoH-like protein DUF815 PF05673.13 AIC16229.1 - 4.7e-05 22.7 0.0 0.13 11.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF815) ABC_tran PF00005.27 AIC16229.1 - 5.3e-05 23.7 0.0 0.48 10.9 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_25 PF13481.6 AIC16229.1 - 6.9e-05 22.5 5.8 1.4 8.5 0.1 4.3 2 2 0 4 4 4 2 AAA domain Zeta_toxin PF06414.12 AIC16229.1 - 9.4e-05 21.8 0.1 0.35 10.1 0.0 2.6 2 0 0 2 2 2 2 Zeta toxin NACHT PF05729.12 AIC16229.1 - 0.00026 21.0 0.1 1.1 9.1 0.0 3.2 3 0 0 3 3 3 2 NACHT domain Cytidylate_kin PF02224.18 AIC16229.1 - 0.00069 19.4 0.1 0.97 9.1 0.0 2.6 2 0 0 2 2 2 2 Cytidylate kinase NB-ARC PF00931.22 AIC16229.1 - 0.0014 17.9 0.0 1 8.5 0.0 2.4 2 0 0 2 2 2 1 NB-ARC domain AAA_3 PF07726.11 AIC16229.1 - 0.0014 18.4 0.0 0.3 11.0 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 AIC16229.1 - 0.002 17.5 0.0 0.79 8.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 AIC16229.1 - 0.0037 17.7 0.0 1.3 9.5 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 AIC16229.1 - 0.0044 16.8 0.8 2.5 7.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain Parvo_NS1 PF01057.17 AIC16229.1 - 0.0063 15.6 0.1 2.4 7.2 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 NTPase_1 PF03266.15 AIC16229.1 - 0.0084 16.0 1.4 10 6.0 0.0 3.9 2 1 1 3 3 3 0 NTPase Guanylate_kin PF00625.21 AIC16229.1 - 0.0086 15.8 0.2 2.6 7.7 0.0 3.4 2 1 1 3 3 3 1 Guanylate kinase Sigma54_activ_2 PF14532.6 AIC16229.1 - 0.015 15.4 0.0 3.3 7.8 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain T2SSE PF00437.20 AIC16229.1 - 0.032 13.3 0.0 5.4 6.0 0.0 2.4 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_11 PF13086.6 AIC16229.1 - 0.041 13.7 0.0 0.82 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 AIC16229.1 - 0.049 12.5 0.1 8.7 5.1 0.0 2.9 3 0 0 3 3 3 0 AFG1-like ATPase CPT PF07931.12 AIC16229.1 - 0.056 13.3 0.0 8.6 6.2 0.0 2.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein TniB PF05621.11 AIC16229.1 - 0.059 12.8 0.0 25 4.2 0.0 3.3 4 0 0 4 4 4 0 Bacterial TniB protein PduV-EutP PF10662.9 AIC16229.1 - 0.06 13.1 0.0 5.8 6.7 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 AIC16229.1 - 0.062 13.6 2.7 3.9 7.8 0.2 3.1 2 1 1 3 3 3 0 AAA domain Rad17 PF03215.15 AIC16229.1 - 0.066 13.1 0.0 34 4.3 0.0 3.2 2 1 1 3 3 3 0 Rad17 P-loop domain ResIII PF04851.15 AIC16229.1 - 0.075 13.0 0.0 17 5.3 0.0 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit KAP_NTPase PF07693.14 AIC16229.1 - 0.079 12.2 0.7 2.7 7.1 0.0 3.0 2 2 2 4 4 4 0 KAP family P-loop domain SRPRB PF09439.10 AIC16229.1 - 0.087 12.2 0.0 14 5.1 0.0 2.5 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit AAA_29 PF13555.6 AIC16229.1 - 0.092 12.5 0.2 15 5.4 0.1 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AIC16229.1 - 0.11 12.4 0.0 7.7 6.4 0.0 2.9 2 0 0 2 2 2 0 RsgA GTPase IPT PF01745.16 AIC16229.1 - 0.16 11.4 0.3 16 4.8 0.1 2.5 2 0 0 2 2 2 0 Isopentenyl transferase ABC2_membrane PF01061.24 AIC16230.1 - 1e-37 129.6 17.7 1e-37 129.6 17.7 1.3 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIC16230.1 - 4.5e-16 58.9 25.1 5.4e-16 58.6 25.1 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 AIC16230.1 - 2.5e-14 53.2 16.8 3.3e-14 52.9 16.8 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein PNTB_4TM PF12769.7 AIC16230.1 - 0.46 11.0 14.8 16 6.1 1.4 4.6 1 1 1 2 2 2 0 4TM region of pyridine nucleotide transhydrogenase, mitoch ABC2_membrane_4 PF12730.7 AIC16230.1 - 5.3 7.0 15.9 0.29 11.1 8.6 2.3 2 1 1 3 3 3 0 ABC-2 family transporter protein ABC_tran PF00005.27 AIC16231.1 - 1.4e-30 106.6 0.2 7.2e-30 104.3 0.0 2.3 3 0 0 3 3 3 1 ABC transporter AAA_21 PF13304.6 AIC16231.1 - 4.6e-12 46.4 0.8 2.5e-08 34.1 0.0 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 AIC16231.1 - 1.9e-10 41.3 0.0 2.6e-09 37.7 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4162) AAA_15 PF13175.6 AIC16231.1 - 0.00027 20.8 1.5 0.084 12.6 0.0 3.2 2 1 2 4 4 4 2 AAA ATPase domain AAA PF00004.29 AIC16231.1 - 0.0082 16.6 0.4 0.047 14.1 0.4 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SMC_N PF02463.19 AIC16231.1 - 0.014 14.8 0.3 4.9 6.5 0.1 2.5 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_30 PF13604.6 AIC16231.1 - 0.033 13.9 0.5 0.12 12.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 AIC16231.1 - 0.062 13.0 0.1 3.1 7.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 AIC16231.1 - 0.083 12.8 0.6 0.3 11.0 0.2 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 AIC16231.1 - 0.12 12.8 0.0 0.24 11.8 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 AIC16231.1 - 6.1 7.3 9.5 0.12 12.8 0.9 2.6 2 1 1 3 3 3 0 AAA domain zf-C2H2_jaz PF12171.8 AIC16232.1 - 1.2e-05 25.5 0.1 1.8e-05 24.9 0.1 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 AIC16232.1 - 2e-05 24.5 0.1 2.5e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC16232.1 - 0.0002 21.6 0.1 0.00029 21.1 0.1 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC16232.1 - 0.0012 19.4 0.2 0.0021 18.8 0.2 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf_UBZ PF18439.1 AIC16232.1 - 0.0017 17.9 0.4 0.0017 17.9 0.4 1.6 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf_C2H2_ZHX PF18387.1 AIC16232.1 - 0.0018 17.9 0.1 0.0018 17.9 0.1 1.5 2 0 0 2 2 2 1 Zinc-fingers and homeoboxes C2H2 finger domain zf-met PF12874.7 AIC16232.1 - 0.0027 18.0 0.1 0.005 17.2 0.0 1.5 2 0 0 2 2 2 1 Zinc-finger of C2H2 type DUF3215 PF11503.8 AIC16234.1 - 0.012 15.4 0.2 0.019 14.8 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3215) Spermine_synth PF01564.17 AIC16236.1 - 0.00044 19.7 0.0 0.00092 18.7 0.0 1.6 1 0 0 1 1 1 1 Spermine/spermidine synthase domain DUF1240 PF06836.12 AIC16236.1 - 0.17 12.4 0.7 1 9.9 0.7 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1240) AsnC_trans_reg PF01037.21 AIC16237.1 - 1.8e-07 31.0 0.0 2.2e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIC16237.1 - 0.00026 21.0 0.0 0.00046 20.2 0.0 1.3 1 0 0 1 1 1 1 NapD protein TIG PF01833.24 AIC16238.1 - 0.012 15.6 1.5 0.012 15.6 1.5 2.2 1 1 1 2 2 2 0 IPT/TIG domain PCuAC PF04314.13 AIC16238.1 - 0.018 14.9 0.2 3.9 7.3 0.0 2.4 1 1 1 2 2 2 0 Copper chaperone PCu(A)C DUF3869 PF12985.7 AIC16238.1 - 1.2 9.5 8.2 1.7 9.0 0.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3869) LTD PF00932.19 AIC16238.1 - 3.9 7.9 6.9 1.2e+02 3.1 6.9 2.9 1 1 0 1 1 1 0 Lamin Tail Domain DUF5519 PF17648.1 AIC16239.1 - 1.5e-19 70.0 0.1 1.5e-19 69.9 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5519) HTH_45 PF14947.6 AIC16240.1 - 8.1e-13 48.2 1.1 8.9e-13 48.0 1.1 1.0 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_27 PF13463.6 AIC16240.1 - 0.00021 21.7 0.1 0.00026 21.4 0.1 1.1 1 0 0 1 1 1 1 Winged helix DNA-binding domain DUF4364 PF14277.6 AIC16240.1 - 0.00034 20.4 0.1 0.00036 20.3 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) Acetyltransf_13 PF13880.6 AIC16240.1 - 0.0045 16.9 0.1 0.27 11.3 0.0 2.1 1 1 1 2 2 2 1 ESCO1/2 acetyl-transferase DUF4423 PF14394.6 AIC16240.1 - 0.034 13.9 0.0 0.037 13.8 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) ER PF01133.17 AIC16240.1 - 0.042 13.9 0.1 0.042 13.9 0.1 1.1 1 0 0 1 1 1 0 Enhancer of rudimentary Polysacc_synt_C PF14667.6 AIC16241.1 - 0.054 13.6 7.5 0.096 12.8 7.5 1.4 1 1 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain Cg6151-P PF10233.9 AIC16241.1 - 0.12 12.7 5.5 0.76 10.1 5.5 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein CG6151-P DUF5453 PF17534.2 AIC16241.1 - 0.18 11.7 6.9 0.1 12.5 5.4 1.3 1 1 0 1 1 1 0 Family of unknown function (DUF5453) DUF4149 PF13664.6 AIC16241.1 - 0.24 11.7 4.1 0.36 11.2 4.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4149) YccF PF03733.13 AIC16241.1 - 4.4 8.1 12.1 0.84 10.4 2.7 3.0 3 1 0 3 3 3 0 Inner membrane component domain DUF2795 PF11387.8 AIC16242.1 - 8.8e-11 41.8 0.1 1.8e-10 40.9 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2795) Phage_integrase PF00589.22 AIC16243.1 - 0.00045 20.1 0.1 0.0081 16.0 0.1 2.4 1 1 0 1 1 1 1 Phage integrase family HTH_38 PF13936.6 AIC16243.1 - 0.0028 17.4 1.6 0.0052 16.5 0.1 2.4 3 0 0 3 3 3 1 Helix-turn-helix domain Bac_DnaA_C PF08299.11 AIC16243.1 - 0.059 13.4 0.1 0.38 10.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial dnaA protein helix-turn-helix HTH_24 PF13412.6 AIC16243.1 - 0.12 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding Cpn60_TCP1 PF00118.24 AIC16246.1 - 1.2e-169 565.0 16.8 1.4e-169 564.9 16.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF3574 PF12098.8 AIC16247.1 - 2.9e-07 30.2 0.0 3.4e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3574) Usp PF00582.26 AIC16248.1 - 5e-31 108.1 0.2 6.3e-31 107.8 0.2 1.1 1 0 0 1 1 1 1 Universal stress protein family bact-PGI_C PF10432.9 AIC16248.1 - 0.018 15.1 0.2 0.045 13.8 0.2 1.6 1 1 1 2 2 2 0 Bacterial phospho-glucose isomerase C-terminal SIS domain Arm-DNA-bind_4 PF14657.6 AIC16248.1 - 0.22 11.3 1.0 0.56 10.0 0.4 1.9 1 1 1 2 2 2 0 Arm DNA-binding domain Activator-TraM PF11657.8 AIC16249.1 - 0.00068 19.5 0.2 0.00072 19.4 0.2 1.0 1 0 0 1 1 1 1 Transcriptional activator TraM Herpes_U34 PF04541.13 AIC16251.1 - 0.15 11.3 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus virion protein U34 CCDC14 PF15254.6 AIC16251.1 - 0.23 10.1 0.0 0.25 10.0 0.0 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 14 TFIIB PF00382.19 AIC16252.1 - 5.2e-20 71.3 1.8 1.1e-09 38.3 0.1 2.3 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 AIC16252.1 - 9.3e-08 31.5 0.1 1.7e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 TFIIB zinc-binding HTH_Crp_2 PF13545.6 AIC16252.1 - 0.00054 19.9 0.1 0.028 14.4 0.0 2.6 2 0 0 2 2 2 1 Crp-like helix-turn-helix domain HTH_24 PF13412.6 AIC16252.1 - 0.00069 19.1 0.3 0.97 9.0 0.0 3.3 3 0 0 3 3 3 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC16252.1 - 0.00077 19.2 0.3 1.9 8.4 0.1 3.4 3 0 0 3 3 3 1 AsnC-type helix-turn-helix domain DUF4684 PF15736.5 AIC16252.1 - 0.002 16.9 1.2 0.003 16.3 1.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4684) HTH_10 PF04967.12 AIC16252.1 - 0.003 17.3 0.3 5.4 6.9 0.0 3.2 3 0 0 3 3 3 1 HTH DNA binding domain HTH_3 PF01381.22 AIC16252.1 - 0.003 17.6 0.0 2.1 8.4 0.0 2.6 2 0 0 2 2 2 2 Helix-turn-helix HTH_11 PF08279.12 AIC16252.1 - 0.0033 17.3 1.3 0.062 13.3 0.0 2.9 4 0 0 4 4 4 1 HTH domain GntR PF00392.21 AIC16252.1 - 0.0087 15.7 0.1 1.3 8.7 0.0 2.8 3 0 0 3 3 3 1 Bacterial regulatory proteins, gntR family Rrf2 PF02082.20 AIC16252.1 - 0.011 16.0 0.0 8.3 6.8 0.0 2.8 3 0 0 3 3 3 0 Transcriptional regulator HTH_Mga PF08280.11 AIC16252.1 - 0.014 15.4 0.1 3.3 7.8 0.0 3.6 4 0 0 4 4 4 0 M protein trans-acting positive regulator (MGA) HTH domain RB_B PF01857.20 AIC16252.1 - 0.015 15.4 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Retinoblastoma-associated protein B domain HTH_36 PF13730.6 AIC16252.1 - 0.082 12.9 0.5 23 5.0 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix domain HTH_28 PF13518.6 AIC16252.1 - 0.26 11.5 2.4 2.2 8.5 0.0 3.5 4 0 0 4 4 4 0 Helix-turn-helix domain HTH_23 PF13384.6 AIC16252.1 - 1.7 8.5 5.3 2.8 7.9 0.0 3.3 4 0 0 4 4 3 0 Homeodomain-like domain Hydrolase_4 PF12146.8 AIC16253.1 - 4.7e-09 35.9 0.1 0.0028 16.9 0.0 3.0 2 1 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 AIC16253.1 - 6.4e-09 35.7 0.0 7.5e-09 35.4 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 AIC16253.1 - 1.1e-07 31.6 0.5 7.4e-05 22.3 0.0 2.8 2 1 1 3 3 3 2 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 AIC16253.1 - 4.9e-06 26.4 0.5 0.56 9.8 0.0 3.1 2 1 1 3 3 3 3 alpha/beta hydrolase fold BAAT_C PF08840.11 AIC16253.1 - 1.3e-05 25.3 0.0 0.019 14.9 0.0 2.1 1 1 1 2 2 2 2 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S15 PF02129.18 AIC16253.1 - 0.00082 19.0 0.1 0.41 10.2 0.0 2.2 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_6 PF12697.7 AIC16253.1 - 0.00099 19.8 0.3 2.6 8.6 0.0 2.1 1 1 1 2 2 2 2 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 AIC16253.1 - 0.029 14.2 0.0 0.83 9.4 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase zf-met PF12874.7 AIC16255.1 - 0.00022 21.5 0.9 0.00022 21.5 0.9 1.8 2 0 0 2 2 2 1 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 AIC16255.1 - 0.00032 21.0 0.6 0.00032 21.0 0.6 2.2 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 AIC16255.1 - 0.0021 18.3 1.6 0.0021 18.3 1.6 1.6 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 AIC16255.1 - 0.0061 17.3 0.7 0.0061 17.3 0.7 2.1 3 0 0 3 3 3 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 AIC16255.1 - 0.0077 16.0 0.9 0.02 14.6 0.1 2.0 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 AIC16255.1 - 0.017 15.1 2.7 0.017 15.1 2.7 1.8 2 1 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.15 AIC16255.1 - 0.094 12.8 1.3 0.21 11.6 1.3 1.6 1 1 0 1 1 1 0 BED zinc finger zf-H2C2_2 PF13465.6 AIC16255.1 - 0.13 12.8 3.9 0.25 11.8 0.1 2.4 2 1 0 2 2 2 0 Zinc-finger double domain TAT_signal PF10518.9 AIC16256.1 - 0.00065 19.4 0.2 0.001 18.8 0.2 1.3 1 0 0 1 1 1 1 TAT (twin-arginine translocation) pathway signal sequence UCR_Fe-S_N PF10399.9 AIC16256.1 - 0.087 12.2 3.3 0.27 10.6 3.3 1.7 1 1 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DDE_Tnp_IS240 PF13610.6 AIC16257.1 - 2.3e-10 40.8 0.1 3.7e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 DDE domain Rieske PF00355.26 AIC16258.1 - 3.9e-06 26.7 0.0 5.1e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Carbpep_Y_N PF05388.11 AIC16259.1 - 0.026 15.1 0.4 0.029 14.9 0.4 1.1 1 0 0 1 1 1 0 Carboxypeptidase Y pro-peptide DUF3490 PF11995.8 AIC16259.1 - 0.031 14.1 1.6 0.03 14.1 1.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3490) Ferritin PF00210.24 AIC16259.1 - 0.043 13.8 1.5 0.049 13.6 1.5 1.1 1 0 0 1 1 1 0 Ferritin-like domain Ferritin_2 PF13668.6 AIC16259.1 - 0.099 12.8 0.2 0.12 12.5 0.2 1.3 1 1 0 1 1 1 0 Ferritin-like domain FliL PF03748.14 AIC16260.1 - 0.078 13.6 0.1 0.11 13.1 0.1 1.2 1 0 0 1 1 1 0 Flagellar basal body-associated protein FliL YvrJ PF12841.7 AIC16261.1 - 0.053 13.1 0.3 0.11 12.0 0.3 1.5 1 0 0 1 1 1 0 YvrJ protein family Cupredoxin_1 PF13473.6 AIC16262.1 - 2.9e-06 27.3 0.0 6.5e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIC16262.1 - 0.00021 21.7 0.0 0.00042 20.7 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cu-oxidase_3 PF07732.15 AIC16262.1 - 0.012 15.6 0.0 5.6 7.0 0.0 2.6 2 0 0 2 2 2 0 Multicopper oxidase Enkurin PF13864.6 AIC16263.1 - 0.054 13.9 3.0 1.2 9.6 0.5 2.4 2 1 0 2 2 2 0 Calmodulin-binding Pox_A_type_inc PF04508.12 AIC16263.1 - 0.12 12.3 0.4 0.3 11.0 0.4 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat DUF1947 PF09183.10 AIC16263.1 - 2.2 8.7 5.7 9.2 6.7 0.3 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1947) DUF4650 PF15509.6 AIC16264.1 - 0.06 12.7 1.0 0.091 12.1 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4650) Pilin_GH PF16734.5 AIC16264.1 - 0.084 13.2 0.2 0.2 12.0 0.2 1.6 1 0 0 1 1 1 0 Type IV pilin-like G and H, putative PD40 PF07676.12 AIC16265.1 - 1.7e-11 43.7 7.4 0.002 18.0 1.6 4.8 4 0 0 4 4 4 4 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 AIC16265.1 - 6.9e-07 28.3 0.0 2.3e-05 23.3 0.0 2.4 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9_N PF02897.15 AIC16265.1 - 4.7e-06 25.7 1.7 0.012 14.4 0.1 2.9 2 2 0 3 3 3 2 Prolyl oligopeptidase, N-terminal beta-propeller domain Pectate_lyase22 PF14583.6 AIC16265.1 - 0.0011 17.7 0.3 0.037 12.7 0.0 2.6 2 2 0 2 2 2 1 Oligogalacturonate lyase Lactonase PF10282.9 AIC16265.1 - 0.017 14.4 0.2 0.19 11.0 0.1 2.3 1 1 2 3 3 3 0 Lactonase, 7-bladed beta-propeller PPC PF04151.15 AIC16265.1 - 0.038 15.1 1.9 0.038 15.1 1.9 3.6 2 2 1 3 3 3 0 Bacterial pre-peptidase C-terminal domain MS_channel PF00924.18 AIC16269.1 - 4.9e-12 45.8 8.7 4.9e-12 45.8 8.7 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel Polysacc_synt_C PF14667.6 AIC16269.1 - 0.41 10.7 18.2 1.2 9.1 18.2 1.7 1 1 0 1 1 1 0 Polysaccharide biosynthesis C-terminal domain DUF21 PF01595.20 AIC16269.1 - 3.6 7.3 14.2 0.12 12.1 6.8 1.9 1 1 1 2 2 2 0 Cyclin M transmembrane N-terminal domain Guanylate_cyc PF00211.20 AIC16270.1 - 8.2e-14 51.6 0.0 1.2e-13 51.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF4677 PF15726.5 AIC16270.1 - 0.025 14.7 0.0 0.043 14.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4677) DUF202 PF02656.15 AIC16272.1 - 0.38 11.2 2.6 0.78 10.2 2.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF202) Tetraspanin PF00335.20 AIC16272.1 - 0.72 9.5 2.8 0.87 9.3 2.8 1.2 1 0 0 1 1 1 0 Tetraspanin family DUF4536 PF15055.6 AIC16272.1 - 5.7 7.3 7.6 0.4 11.0 1.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4536) Peptidase_M48 PF01435.18 AIC16273.1 - 2.2e-38 132.0 0.0 1.7e-37 129.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 AIC16273.1 - 4e-08 32.8 0.1 8.2e-07 28.5 0.0 2.0 2 0 0 2 2 2 1 BlaR1 peptidase M56 DUF4853 PF16145.5 AIC16273.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) DUF3810 PF12725.7 AIC16273.1 - 6 6.1 7.3 0.72 9.1 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) Phage_holin_3_6 PF07332.11 AIC16273.1 - 6.2 6.9 11.7 12 5.9 2.9 2.5 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III HTH_45 PF14947.6 AIC16274.1 - 3.1e-14 52.7 0.0 4e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix UNC119_bdg PF15435.6 AIC16274.1 - 0.04 13.5 0.2 0.18 11.4 0.0 1.8 2 0 0 2 2 2 0 UNC119-binding protein C5orf30 homologue Ferritin PF00210.24 AIC16275.1 - 1.7e-23 83.1 0.0 2.1e-23 82.8 0.0 1.1 1 0 0 1 1 1 1 Ferritin-like domain Ferritin_2 PF13668.6 AIC16275.1 - 0.085 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Ferritin-like domain COQ7 PF03232.13 AIC16275.1 - 0.12 12.1 0.0 0.31 10.8 0.0 1.6 2 0 0 2 2 2 0 Ubiquinone biosynthesis protein COQ7 Rieske PF00355.26 AIC16276.1 - 3.7e-13 49.2 0.2 5.6e-13 48.6 0.2 1.3 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIC16276.1 - 0.013 15.4 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Rieske-like [2Fe-2S] domain FG-GAP PF01839.23 AIC16276.1 - 0.44 10.7 3.3 2.8 8.2 0.1 2.2 2 0 0 2 2 2 0 FG-GAP repeat NAD_synthase PF02540.17 AIC16278.1 - 6.2e-78 261.3 0.0 7.2e-78 261.0 0.0 1.0 1 0 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 AIC16278.1 - 9.2e-07 28.8 0.0 1.5e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase tRNA_Me_trans PF03054.16 AIC16278.1 - 1e-05 24.6 0.0 0.0003 19.7 0.0 2.5 3 0 0 3 3 3 1 tRNA methyl transferase HTH_23 PF13384.6 AIC16278.1 - 0.0015 18.3 0.0 0.027 14.3 0.0 2.7 3 0 0 3 3 3 1 Homeodomain-like domain QueC PF06508.13 AIC16278.1 - 0.0053 16.3 0.0 0.01 15.3 0.0 1.5 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC Sigma70_r4 PF04545.16 AIC16278.1 - 0.047 13.2 0.0 0.15 11.6 0.0 1.9 1 1 0 1 1 1 0 Sigma-70, region 4 DUF726 PF05277.12 AIC16278.1 - 0.12 11.2 0.9 0.22 10.4 0.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF726) AP_endonuc_2 PF01261.24 AIC16279.1 - 0.00011 21.7 0.0 0.00033 20.2 0.0 1.9 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel PsbP PF01789.16 AIC16280.1 - 0.0084 16.2 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 1 PsbP adh_short PF00106.25 AIC16283.1 - 2.3e-36 125.1 0.3 1.4e-35 122.5 0.3 1.9 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 AIC16283.1 - 1.1e-28 100.4 0.9 3.7e-28 98.7 0.9 1.8 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 AIC16283.1 - 5.7e-09 36.1 0.5 5.7e-09 36.1 0.5 1.5 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 AIC16283.1 - 0.0032 17.0 0.2 0.0071 15.8 0.2 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3HCDH_N PF02737.18 AIC16283.1 - 0.047 13.6 0.1 0.083 12.8 0.1 1.4 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 AIC16283.1 - 0.069 13.2 0.5 0.14 12.3 0.5 1.4 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain NAD_binding_7 PF13241.6 AIC16283.1 - 0.07 13.6 0.2 0.17 12.4 0.2 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 AIC16283.1 - 0.086 12.2 0.3 0.16 11.3 0.3 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain THF_DHG_CYH_C PF02882.19 AIC16283.1 - 0.1 11.9 0.2 0.19 11.1 0.2 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Ribonuc_red_lgC PF02867.15 AIC16284.1 - 5.6e-188 625.7 0.0 1.1e-187 624.8 0.0 1.5 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 AIC16284.1 - 1e-31 108.7 0.0 3.7e-31 107.0 0.0 2.0 1 1 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 AIC16284.1 - 1.5e-17 64.0 0.3 5e-17 62.3 0.3 2.0 1 0 0 1 1 1 1 ATP cone domain DZR PF12773.7 AIC16284.1 - 0.071 13.1 1.3 0.13 12.3 1.3 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC16284.1 - 0.074 12.5 3.4 0.16 11.4 3.4 1.6 1 0 0 1 1 1 0 zinc-ribbon domain NRDD PF13597.6 AIC16285.1 - 2e-17 63.2 0.0 3.7e-13 49.1 0.0 2.4 2 0 0 2 2 2 2 Anaerobic ribonucleoside-triphosphate reductase HTH_20 PF12840.7 AIC16285.1 - 1.1e-09 38.2 0.0 4.9e-09 36.1 0.0 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain ATP-cone PF03477.16 AIC16285.1 - 1.7e-09 38.1 0.2 5.4e-09 36.5 0.2 1.9 1 0 0 1 1 1 1 ATP cone domain Flu_NP PF00506.18 AIC16285.1 - 0.017 13.8 0.0 0.027 13.2 0.0 1.3 1 0 0 1 1 1 0 Influenza virus nucleoprotein Lig_C PF18330.1 AIC16285.1 - 0.017 15.1 0.1 0.99 9.4 0.0 2.5 2 0 0 2 2 2 0 Ligase Pab1020 C-terminal region ZT_dimer PF16916.5 AIC16285.1 - 0.029 14.5 0.0 0.072 13.2 0.0 1.6 1 0 0 1 1 1 0 Dimerisation domain of Zinc Transporter Snf7 PF03357.21 AIC16286.1 - 4.9e-05 23.0 4.1 9.7e-05 22.0 4.1 1.5 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 AIC16286.1 - 0.0038 17.2 0.1 0.0072 16.3 0.1 1.4 1 0 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway TF_Zn_Ribbon PF08271.12 AIC16287.1 - 6.1e-05 22.4 2.6 0.019 14.4 0.5 2.1 1 1 1 2 2 2 2 TFIIB zinc-binding zf-RRN7 PF11781.8 AIC16287.1 - 0.00017 21.2 0.6 0.47 10.2 0.0 2.1 2 0 0 2 2 2 2 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zf-ribbon_3 PF13248.6 AIC16287.1 - 0.00021 20.5 2.8 0.17 11.4 0.4 2.1 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 AIC16287.1 - 0.0012 18.8 0.2 0.0015 18.5 0.2 1.3 1 1 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 AIC16287.1 - 0.0018 18.0 0.5 0.39 10.5 0.1 2.1 2 0 0 2 2 2 1 zinc-ribbon domain zf-NADH-PPase PF09297.11 AIC16287.1 - 0.0019 17.8 1.2 0.39 10.4 0.1 2.2 2 0 0 2 2 2 2 NADH pyrophosphatase zinc ribbon domain zf-ACC PF17848.1 AIC16287.1 - 0.0035 17.4 0.3 0.68 10.1 0.1 2.2 2 0 0 2 2 2 1 Acetyl-coA carboxylase zinc finger domain Prok-RING_1 PF14446.6 AIC16287.1 - 0.0049 16.8 0.7 0.58 10.1 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 AIC16287.1 - 0.011 15.8 0.8 0.036 14.2 0.8 1.7 1 1 0 1 1 1 0 Zinc ribbon domain ADK_lid PF05191.14 AIC16287.1 - 0.012 15.6 0.3 0.018 15.0 0.3 1.3 1 0 0 1 1 1 0 Adenylate kinase, active site lid Rad50_zn_hook PF04423.14 AIC16287.1 - 0.012 15.4 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C2HC5 PF06221.13 AIC16287.1 - 0.018 15.0 0.5 0.041 13.9 0.5 1.6 1 1 0 1 1 1 0 Putative zinc finger motif, C2HC5-type Zn_ribbon_recom PF13408.6 AIC16287.1 - 0.019 15.5 0.2 1.6 9.3 0.1 2.1 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Rtf2 PF04641.12 AIC16287.1 - 0.02 14.3 0.3 0.022 14.2 0.3 1.0 1 0 0 1 1 1 0 Rtf2 RING-finger zinc_ribbon_15 PF17032.5 AIC16287.1 - 0.037 14.8 0.1 0.044 14.5 0.1 1.1 1 0 0 1 1 1 0 zinc-ribbon family zinc_ribbon_5 PF13719.6 AIC16287.1 - 0.05 13.4 1.1 1.1 9.1 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-TFIIB PF13453.6 AIC16287.1 - 0.06 12.7 0.5 0.25 10.7 0.0 1.9 2 0 0 2 2 2 0 Transcription factor zinc-finger zf_UBZ PF18439.1 AIC16287.1 - 0.093 12.3 0.1 4.3 7.0 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Ribosomal_S27 PF01599.19 AIC16287.1 - 0.13 12.5 2.0 6.4 7.0 0.1 2.1 2 0 0 2 2 2 0 Ribosomal protein S27a DNA_ligase_ZBD PF03119.16 AIC16287.1 - 0.16 12.0 0.7 0.16 12.0 0.7 2.2 2 1 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Nop10p PF04135.12 AIC16287.1 - 0.17 12.0 1.2 7.8 6.6 0.1 2.1 1 1 1 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family Nudix_N_2 PF14803.6 AIC16287.1 - 0.18 11.7 5.0 2.5 8.1 0.9 2.2 2 0 0 2 2 2 0 Nudix N-terminal zf-C2H2_12 PF18658.1 AIC16287.1 - 0.34 10.5 1.6 7.5 6.2 0.3 2.0 1 1 1 2 2 2 0 Zinc-finger C2H2-type Zn_Tnp_IS1595 PF12760.7 AIC16287.1 - 0.53 10.3 3.0 5 7.2 0.2 2.1 1 1 1 2 2 2 0 Transposase zinc-ribbon domain Seryl_tRNA_N PF02403.22 AIC16288.1 - 0.076 13.3 7.3 0.11 12.7 7.3 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Occludin_ELL PF07303.13 AIC16288.1 - 0.19 12.5 6.9 0.28 11.9 0.1 2.7 1 1 1 2 2 2 0 Occludin homology domain NPV_P10 PF05531.12 AIC16288.1 - 0.28 11.7 3.1 3.1 8.3 2.4 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Nup54_57_C PF18570.1 AIC16288.1 - 0.63 9.7 0.2 0.63 9.7 0.2 3.3 4 0 0 4 4 4 0 NUP57/Nup54 C-terminal domain UPF0449 PF15136.6 AIC16288.1 - 1.1 9.8 7.6 5.1 7.6 0.7 2.6 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 APG6_N PF17675.1 AIC16288.1 - 2.1 8.9 10.5 6.9 7.2 1.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region XhlA PF10779.9 AIC16288.1 - 9.4 6.5 13.5 1.6 9.0 5.1 2.4 2 1 1 3 3 3 0 Haemolysin XhlA OB_aCoA_assoc PF01796.17 AIC16289.1 - 9.6e-06 25.5 0.1 1.4e-05 25.0 0.1 1.3 1 0 0 1 1 1 1 DUF35 OB-fold domain, acyl-CoA-associated zinc_ribbon_2 PF13240.6 AIC16289.1 - 0.00014 21.4 0.6 0.00026 20.6 0.6 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DUF35_N PF12172.8 AIC16289.1 - 0.00088 19.1 0.1 0.0014 18.5 0.1 1.3 1 0 0 1 1 1 1 Rubredoxin-like zinc ribbon domain (DUF35_N) zinc_ribbon_15 PF17032.5 AIC16289.1 - 0.006 17.3 1.0 0.0083 16.9 1.0 1.2 1 0 0 1 1 1 1 zinc-ribbon family TackOD1 PF18551.1 AIC16289.1 - 0.015 15.0 0.5 0.02 14.6 0.5 1.1 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 MTHFR_C PF12225.8 AIC16289.1 - 0.018 14.7 0.6 0.027 14.1 0.6 1.2 1 0 0 1 1 1 0 Methylene-tetrahydrofolate reductase C terminal DZR PF12773.7 AIC16289.1 - 0.025 14.6 0.5 0.038 14.0 0.5 1.2 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 AIC16289.1 - 0.032 14.1 0.9 1.1 9.3 0.2 2.9 3 0 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_13 PF09855.9 AIC16289.1 - 0.045 13.9 0.5 8.6 6.6 0.1 2.3 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) Thiolase_N PF00108.23 AIC16290.1 - 7.9e-24 84.4 0.2 1.8e-23 83.3 0.2 1.6 1 1 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 AIC16290.1 - 2e-13 50.1 0.7 1.5e-09 37.5 0.0 3.5 2 2 1 3 3 3 2 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 AIC16290.1 - 1.9e-05 24.4 2.3 0.018 14.7 0.6 2.6 2 1 1 3 3 3 2 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 AIC16290.1 - 0.0046 17.0 0.5 0.48 10.5 0.0 3.3 3 0 0 3 3 3 1 Beta-ketoacyl synthase, C-terminal domain Topoisom_bac PF01131.20 AIC16291.1 - 3.5e-108 362.2 0.0 4.2e-108 362.0 0.0 1.1 1 0 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 AIC16291.1 - 9.3e-14 51.5 0.0 2.2e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Toprim domain zf-C4_Topoisom PF01396.19 AIC16291.1 - 0.00044 20.0 1.6 0.00086 19.0 1.6 1.5 1 0 0 1 1 1 1 Topoisomerase DNA binding C4 zinc finger DUF2367 PF10164.9 AIC16291.1 - 0.0054 17.2 0.1 0.012 16.1 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2367) bPH_3 PF14470.6 AIC16293.1 - 1.6e-14 54.1 0.0 4.5e-13 49.4 0.0 2.3 1 1 0 1 1 1 1 Bacterial PH domain SHOCT PF09851.9 AIC16293.1 - 3.4e-09 36.1 2.6 2.3e-08 33.5 2.5 2.2 2 0 0 2 2 2 1 Short C-terminal domain bPH_2 PF03703.14 AIC16293.1 - 0.099 12.9 0.4 0.38 11.0 0.4 2.0 1 1 0 1 1 1 0 Bacterial PH domain CN_hydrolase PF00795.22 AIC16294.1 - 2.1e-53 181.3 0.1 2.4e-53 181.2 0.1 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Tautomerase PF01361.21 AIC16295.1 - 7e-15 54.7 0.1 7.5e-15 54.6 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.6 AIC16295.1 - 2.6e-09 37.0 0.0 2.9e-09 36.9 0.0 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_3 PF14832.6 AIC16295.1 - 0.0028 17.9 0.0 0.0029 17.8 0.0 1.0 1 0 0 1 1 1 1 Putative oxalocrotonate tautomerase enzyme Ketoacyl-synt_2 PF13723.6 AIC16295.1 - 0.031 13.9 0.0 0.035 13.7 0.0 1.0 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain DUF3775 PF12616.8 AIC16295.1 - 0.14 12.2 0.0 0.2 11.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) HTH_3 PF01381.22 AIC16296.1 - 3e-08 33.6 0.0 4.7e-08 33.0 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 AIC16296.1 - 4.5e-07 30.1 0.0 7.5e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 AIC16296.1 - 6.9e-07 29.2 0.0 1.1e-06 28.6 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain MerR_1 PF13411.6 AIC16296.1 - 0.083 13.0 0.0 3.1 7.9 0.0 2.3 1 1 1 2 2 2 0 MerR HTH family regulatory protein DUF3606 PF12244.8 AIC16296.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3606) UDG PF03167.19 AIC16297.1 - 6.3e-34 117.2 0.0 8.8e-34 116.7 0.0 1.2 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily TFIIE_alpha PF02002.17 AIC16298.1 - 4.3e-19 68.3 1.0 4.3e-19 68.3 1.0 1.8 2 0 0 2 2 2 1 TFIIE alpha subunit zf_CopZ PF18423.1 AIC16298.1 - 0.0072 16.3 1.7 1.3 9.0 0.2 2.4 1 1 1 2 2 2 2 Zinc binding domain FucT_N PF18025.1 AIC16298.1 - 0.063 13.7 0.1 0.12 12.8 0.1 1.4 1 0 0 1 1 1 0 Alpha-(1,3)-fucosyltransferase FucT N-terminal domain Sushi_2 PF09014.10 AIC16298.1 - 0.097 12.6 0.7 0.17 11.8 0.7 1.4 1 0 0 1 1 1 0 Beta-2-glycoprotein-1 fifth domain HTH_9 PF08221.11 AIC16298.1 - 0.13 12.4 0.0 0.22 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain Rad50_zn_hook PF04423.14 AIC16298.1 - 0.74 9.7 0.0 0.74 9.7 0.0 3.0 2 1 1 3 3 3 0 Rad50 zinc hook motif RNA_pol_Rpc4 PF05132.14 AIC16298.1 - 2.3 8.6 6.7 3.1 8.2 6.7 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 D5_N PF08706.11 AIC16298.1 - 5.7 7.2 11.6 45 4.3 11.6 2.1 1 1 0 1 1 1 0 D5 N terminal like VMA21 PF09446.10 AIC16299.1 - 0.027 14.6 0.7 0.053 13.6 0.7 1.5 1 0 0 1 1 1 0 VMA21-like domain Guanylate_cyc PF00211.20 AIC16301.1 - 1.1e-14 54.5 0.0 2.2e-14 53.5 0.0 1.5 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain HTH_29 PF13551.6 AIC16301.1 - 0.0033 17.4 0.0 0.022 14.8 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix RNA_polI_A14 PF08203.11 AIC16301.1 - 0.036 14.8 2.1 1.3 9.8 0.3 2.3 1 1 1 2 2 2 0 Yeast RNA polymerase I subunit RPA14 HTH_23 PF13384.6 AIC16301.1 - 0.065 13.1 0.0 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 Homeodomain-like domain PG_binding_4 PF12229.8 AIC16301.1 - 0.072 13.4 0.0 1.4 9.2 0.0 2.4 2 0 0 2 2 2 0 Putative peptidoglycan binding domain Response_reg PF00072.24 AIC16303.1 - 5.4e-14 52.3 0.1 6e-14 52.2 0.1 1.1 1 0 0 1 1 1 1 Response regulator receiver domain COX15-CtaA PF02628.15 AIC16304.1 - 2.7e-09 36.6 16.3 5.7e-07 28.9 11.0 2.2 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein DUF2070 PF09843.9 AIC16304.1 - 0.12 10.7 4.4 0.14 10.5 4.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MPS-4 PF17523.2 AIC16304.1 - 1.1 9.4 3.9 0.36 11.0 0.4 1.9 2 0 0 2 2 2 0 MinK-related peptide, potassium channel accessory sub-unit protein 4 Ldr_toxin PF13940.6 AIC16304.1 - 7.1 6.8 7.9 8.1 6.6 0.7 2.7 3 0 0 3 3 3 0 Toxin Ldr, type I toxin-antitoxin system zf_UBZ PF18439.1 AIC16305.1 - 0.00068 19.2 1.8 0.21 11.2 0.2 2.1 1 1 1 2 2 2 2 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIC16305.1 - 0.001 19.0 0.7 0.0012 18.8 0.7 1.1 1 0 0 1 1 1 1 Double zinc ribbon DNA_RNApol_7kD PF03604.13 AIC16305.1 - 0.0011 18.6 1.4 0.14 11.9 0.1 2.1 2 0 0 2 2 2 2 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_2 PF13240.6 AIC16305.1 - 0.028 14.1 2.1 0.05 13.3 2.1 1.5 1 1 0 1 1 1 0 zinc-ribbon domain PHD PF00628.29 AIC16305.1 - 0.035 14.0 1.2 0.05 13.5 1.2 1.2 1 0 0 1 1 1 0 PHD-finger zf-trcl PF13451.6 AIC16305.1 - 0.09 12.7 2.5 0.15 12.0 0.1 1.9 2 0 0 2 2 2 0 Probable zinc-ribbon domain HypA PF01155.19 AIC16305.1 - 0.098 12.7 0.5 0.1 12.7 0.5 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Paired_CXXCH_1 PF09699.10 AIC16305.1 - 0.27 11.0 4.5 0.7 9.7 4.7 1.6 1 1 1 2 2 2 0 Doubled CXXCH motif (Paired_CXXCH_1) HTH_24 PF13412.6 AIC16306.1 - 0.00013 21.4 0.1 0.00029 20.3 0.1 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_11 PF08279.12 AIC16306.1 - 0.00029 20.7 0.1 0.00068 19.5 0.1 1.6 1 0 0 1 1 1 1 HTH domain HTH_AsnC-type PF13404.6 AIC16306.1 - 0.0015 18.3 0.1 0.0028 17.5 0.1 1.5 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain Mga PF05043.13 AIC16306.1 - 0.044 14.4 0.1 0.17 12.5 0.0 2.0 1 1 0 1 1 1 0 Mga helix-turn-helix domain HTH_23 PF13384.6 AIC16306.1 - 0.045 13.5 0.0 0.13 12.1 0.0 1.7 2 0 0 2 2 2 0 Homeodomain-like domain DNA_pol_E_B PF04042.16 AIC16308.1 - 1.7e-19 70.0 0.0 6.1e-19 68.2 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase alpha/epsilon subunit B Metallophos PF00149.28 AIC16308.1 - 1.1e-08 35.8 0.0 1.9e-08 35.0 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AIC16308.1 - 1.7e-08 34.8 0.0 7.3e-08 32.8 0.0 2.0 2 1 0 2 2 2 1 Calcineurin-like phosphoesterase superfamily domain tRNA_anti-codon PF01336.25 AIC16308.1 - 3e-05 23.9 0.0 5.6e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF2415 PF10313.9 AIC16308.1 - 0.11 12.4 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Sec23_trunk PF04811.15 AIC16308.1 - 0.15 11.6 0.1 0.41 10.2 0.1 1.7 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain Cdc6_C PF09079.11 AIC16309.1 - 3.6e-19 68.5 0.2 1.3e-18 66.8 0.1 2.0 2 0 0 2 2 1 1 CDC6, C terminal winged helix domain AAA PF00004.29 AIC16309.1 - 1.5e-12 48.1 2.4 2.4e-12 47.4 0.1 2.5 3 1 0 3 3 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AIC16309.1 - 9.8e-11 42.3 2.6 3.3e-10 40.6 0.1 2.8 2 2 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AIC16309.1 - 3.2e-10 40.4 0.1 1.3e-09 38.4 0.0 2.0 2 0 0 2 2 2 1 AAA domain TniB PF05621.11 AIC16309.1 - 2.9e-07 30.1 0.0 6.4e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein AAA_19 PF13245.6 AIC16309.1 - 8.1e-06 26.2 0.7 5e-05 23.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 AIC16309.1 - 9e-06 25.0 0.4 4.7e-05 22.7 0.0 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 AIC16309.1 - 0.00022 21.2 0.3 0.00022 21.2 0.3 2.2 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea NACHT PF05729.12 AIC16309.1 - 0.00044 20.2 1.5 0.0039 17.1 0.4 2.7 2 1 0 2 2 2 1 NACHT domain KAP_NTPase PF07693.14 AIC16309.1 - 0.0038 16.5 1.9 0.19 11.0 0.0 2.4 1 1 1 2 2 2 1 KAP family P-loop domain NB-ARC PF00931.22 AIC16309.1 - 0.0049 16.1 0.1 0.009 15.2 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain Zeta_toxin PF06414.12 AIC16309.1 - 0.0059 15.9 1.7 0.01 15.2 0.1 2.2 2 1 0 2 2 2 1 Zeta toxin AAA_24 PF13479.6 AIC16309.1 - 0.012 15.4 0.4 0.039 13.7 0.4 1.9 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 AIC16309.1 - 0.014 15.4 0.4 0.053 13.5 0.0 2.1 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_33 PF13671.6 AIC16309.1 - 0.02 15.0 0.7 0.096 12.9 0.6 2.3 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 AIC16309.1 - 0.022 14.8 0.5 0.12 12.4 0.1 2.4 3 1 0 3 3 2 0 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 AIC16309.1 - 0.023 14.2 0.0 0.057 12.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_assoc_2 PF16193.5 AIC16309.1 - 0.024 15.0 2.4 0.094 13.1 2.3 2.2 1 1 0 1 1 1 0 AAA C-terminal domain DUF2075 PF09848.9 AIC16309.1 - 0.038 13.2 0.5 0.068 12.4 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) MMR_HSR1 PF01926.23 AIC16309.1 - 0.046 13.8 0.1 0.13 12.4 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sigma54_activat PF00158.26 AIC16309.1 - 0.054 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 AIC16309.1 - 0.06 13.1 0.1 0.06 13.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 AIC16309.1 - 0.077 13.0 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 AIC16309.1 - 0.089 13.3 2.6 4 8.0 0.1 3.1 2 2 1 3 3 3 0 ABC transporter Pox_A32 PF04665.12 AIC16309.1 - 0.1 12.0 0.3 0.35 10.3 0.0 1.8 2 0 0 2 2 2 0 Poxvirus A32 protein RuvB_N PF05496.12 AIC16309.1 - 0.12 12.2 0.8 4.1 7.1 0.1 2.4 1 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain NTPase_1 PF03266.15 AIC16309.1 - 0.12 12.3 2.3 0.6 10.0 2.3 2.1 1 1 0 1 1 1 0 NTPase RNA_helicase PF00910.22 AIC16309.1 - 0.14 12.6 0.0 0.37 11.2 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Phage-MuB_C PF09077.11 AIC16309.1 - 0.14 12.0 1.3 0.41 10.5 1.3 1.8 1 0 0 1 1 1 0 Mu B transposition protein, C terminal AAA_11 PF13086.6 AIC16309.1 - 0.19 11.5 3.3 1.1 8.9 3.3 2.1 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 AIC16309.1 - 0.24 10.7 4.0 0.16 11.3 0.6 2.3 2 2 0 2 2 2 0 KaiC DUF4367 PF14285.6 AIC16310.1 - 0.046 14.2 2.2 0.37 11.3 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4367) HTH_ABP1_N PF18107.1 AIC16310.1 - 0.048 13.4 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain Penicillinase_R PF03965.16 AIC16310.1 - 0.05 14.0 0.0 0.074 13.4 0.0 1.3 1 0 0 1 1 1 0 Penicillinase repressor HTH_27 PF13463.6 AIC16311.1 - 0.00011 22.6 0.3 0.00031 21.2 0.1 1.8 2 0 0 2 2 2 1 Winged helix DNA-binding domain TrmB PF01978.19 AIC16311.1 - 0.00017 21.4 0.0 0.00032 20.5 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB Replic_Relax PF13814.6 AIC16311.1 - 0.00072 19.7 1.7 0.001 19.2 0.5 1.7 2 0 0 2 2 2 1 Replication-relaxation LCE6A PF15858.5 AIC16311.1 - 0.0057 17.4 1.0 0.013 16.2 1.0 1.6 2 0 0 2 2 1 1 Late cornified envelope protein 6A family HTH_Crp_2 PF13545.6 AIC16311.1 - 0.016 15.1 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_20 PF12840.7 AIC16311.1 - 0.031 14.3 0.1 0.084 12.9 0.1 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_IclR PF09339.10 AIC16311.1 - 0.057 13.2 0.3 0.1 12.4 0.3 1.4 1 0 0 1 1 1 0 IclR helix-turn-helix domain HxlR PF01638.17 AIC16311.1 - 0.062 13.1 0.1 0.14 12.0 0.1 1.5 1 0 0 1 1 1 0 HxlR-like helix-turn-helix Crp PF00325.20 AIC16311.1 - 0.091 12.4 0.0 0.26 11.0 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family PKcGMP_CC PF16808.5 AIC16311.1 - 0.2 11.5 0.9 0.31 10.9 0.1 1.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Spt20 PF12090.8 AIC16311.1 - 8.7 5.9 10.4 19 4.7 10.4 1.7 1 1 0 1 1 1 0 Spt20 family PcrB PF01884.17 AIC16313.1 - 1.8e-54 184.6 0.2 2.2e-54 184.3 0.2 1.0 1 0 0 1 1 1 1 PcrB family His_biosynth PF00977.21 AIC16313.1 - 2.4e-08 33.7 0.1 2.8e-07 30.2 0.0 2.1 2 0 0 2 2 2 1 Histidine biosynthesis protein IMPDH PF00478.25 AIC16313.1 - 1.7e-05 24.0 0.2 0.00019 20.5 0.0 1.9 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain Trp_syntA PF00290.20 AIC16313.1 - 0.00018 20.4 0.5 0.0006 18.7 0.2 1.8 2 0 0 2 2 2 1 Tryptophan synthase alpha chain NanE PF04131.14 AIC16313.1 - 0.00057 19.1 1.1 0.0086 15.3 0.1 2.3 2 0 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase Glyco_tran_WecB PF03808.13 AIC16313.1 - 0.00094 19.2 0.1 0.0081 16.1 0.0 2.1 2 0 0 2 2 2 1 Glycosyl transferase WecB/TagA/CpsF family ThiG PF05690.14 AIC16313.1 - 0.0013 18.1 1.4 0.073 12.4 0.2 2.1 2 0 0 2 2 2 1 Thiazole biosynthesis protein ThiG Ribul_P_3_epim PF00834.19 AIC16313.1 - 0.0026 17.2 0.5 0.0049 16.3 0.3 1.5 2 0 0 2 2 2 1 Ribulose-phosphate 3 epimerase family B12-binding PF02310.19 AIC16313.1 - 0.013 15.5 2.0 0.58 10.2 0.3 3.4 3 1 0 3 3 3 0 B12 binding domain TMP-TENI PF02581.17 AIC16313.1 - 0.014 14.8 0.2 0.032 13.6 0.0 1.6 2 0 0 2 2 2 0 Thiamine monophosphate synthase IGPS PF00218.21 AIC16313.1 - 0.016 14.4 0.1 0.36 9.9 0.0 2.1 2 0 0 2 2 2 0 Indole-3-glycerol phosphate synthase DHO_dh PF01180.21 AIC16313.1 - 0.017 14.4 0.5 0.017 14.4 0.5 1.6 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase Dus PF01207.17 AIC16313.1 - 0.03 13.4 0.4 2.9 6.9 0.0 2.2 2 0 0 2 2 2 0 Dihydrouridine synthase (Dus) OMPdecase PF00215.24 AIC16313.1 - 0.076 12.6 0.1 0.14 11.7 0.1 1.5 1 0 0 1 1 1 0 Orotidine 5'-phosphate decarboxylase / HUMPS family Matrix PF00661.21 AIC16313.1 - 0.16 10.7 0.0 0.2 10.3 0.0 1.2 1 0 0 1 1 1 0 Viral matrix protein Histidinol_dh PF00815.20 AIC16313.1 - 0.25 10.3 2.3 0.36 9.8 0.3 2.0 1 1 2 3 3 3 0 Histidinol dehydrogenase PolC_DP2 PF03833.13 AIC16314.1 - 0 1033.9 0.0 0 1031.8 0.0 1.8 2 0 0 2 2 2 1 DNA polymerase II large subunit DP2 zinc-ribbons_6 PF07191.12 AIC16314.1 - 0.047 13.7 18.0 0.29 11.1 0.3 3.1 2 1 1 3 3 3 0 zinc-ribbons HNH_5 PF14279.6 AIC16314.1 - 0.053 13.4 0.3 1.4 8.9 0.0 3.0 1 1 1 2 2 2 0 HNH endonuclease DZR PF12773.7 AIC16314.1 - 0.68 10.0 19.9 1.4 9.0 0.8 3.2 2 1 0 2 2 2 0 Double zinc ribbon HypA PF01155.19 AIC16314.1 - 0.79 9.8 15.1 0.79 9.8 0.1 3.9 3 1 0 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1258 PF06869.12 AIC16314.1 - 3 7.3 5.9 8.8 5.7 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1258) SDA1 PF05285.12 AIC16315.1 - 8.9 5.6 14.3 11 5.3 14.3 1.2 1 0 0 1 1 1 0 SDA1 ThiF PF00899.21 AIC16316.1 - 5.2e-72 242.1 0.1 7.4e-72 241.6 0.1 1.1 1 0 0 1 1 1 1 ThiF family ThiS PF02597.20 AIC16316.1 - 1.3e-09 38.6 0.0 7.2e-09 36.2 0.0 2.3 2 0 0 2 2 2 1 ThiS family Sacchrp_dh_NADP PF03435.18 AIC16316.1 - 7.7e-06 26.2 1.3 9.7e-05 22.6 0.5 2.7 1 1 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 AIC16316.1 - 3e-05 24.1 0.2 6.3e-05 23.1 0.2 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase NAD_binding_7 PF13241.6 AIC16316.1 - 0.0023 18.3 0.2 0.0059 17.0 0.2 1.7 1 0 0 1 1 1 1 Putative NAD(P)-binding UDPG_MGDP_dh_N PF03721.14 AIC16316.1 - 0.016 14.8 0.3 0.034 13.7 0.3 1.5 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TBP PF00352.21 AIC16316.1 - 0.031 14.2 0.0 0.21 11.6 0.0 2.2 2 0 0 2 2 2 0 Transcription factor TFIID (or TATA-binding protein, TBP) 2-Hacid_dh_C PF02826.19 AIC16316.1 - 0.034 13.5 0.1 0.06 12.7 0.1 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 AIC16316.1 - 0.05 12.7 0.0 0.095 11.8 0.0 1.4 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PALP PF00291.25 AIC16317.1 - 5.3e-70 236.2 0.6 6.2e-70 235.9 0.6 1.0 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme NinF PF05810.12 AIC16317.1 - 0.012 15.5 0.1 0.031 14.1 0.1 1.7 1 0 0 1 1 1 0 NinF protein C1_2 PF03107.16 AIC16317.1 - 0.16 12.3 1.1 0.28 11.5 1.1 1.4 1 0 0 1 1 1 0 C1 domain HypA PF01155.19 AIC16317.1 - 0.16 12.0 0.5 0.32 11.0 0.5 1.4 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_2 PF13240.6 AIC16317.1 - 1.8 8.4 4.8 3.1 7.6 4.8 1.4 1 0 0 1 1 1 0 zinc-ribbon domain PRA-CH PF01502.18 AIC16318.1 - 1.3e-32 111.5 0.1 1.6e-32 111.2 0.1 1.1 1 0 0 1 1 1 1 Phosphoribosyl-AMP cyclohydrolase RBM39linker PF15519.6 AIC16319.1 - 0.019 16.0 0.2 0.021 15.9 0.2 1.0 1 0 0 1 1 1 0 linker between RRM2 and RRM3 domains in RBM39 protein LapA_dom PF06305.11 AIC16319.1 - 1.2 9.0 4.4 1.4 8.8 4.4 1.1 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF1743 PF08489.11 AIC16321.1 - 1.2e-34 118.8 0.0 2e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1743) C1_2 PF03107.16 AIC16321.1 - 0.034 14.4 0.2 0.075 13.4 0.2 1.5 1 0 0 1 1 1 0 C1 domain OrfB_Zn_ribbon PF07282.11 AIC16321.1 - 0.072 13.0 1.0 0.18 11.8 1.0 1.6 1 0 0 1 1 1 0 Putative transposase DNA-binding domain C1_1 PF00130.22 AIC16321.1 - 0.08 12.8 2.9 0.11 12.4 1.7 1.8 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_ribbon_recom PF13408.6 AIC16321.1 - 0.12 12.9 2.7 0.38 11.3 2.7 1.8 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain YCII PF03795.14 AIC16321.1 - 0.14 12.6 0.0 0.96 9.9 0.0 2.2 2 0 0 2 2 2 0 YCII-related domain Fer4 PF00037.27 AIC16323.1 - 6e-11 41.7 10.4 4.9e-07 29.3 0.7 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_7 PF12838.7 AIC16323.1 - 3.9e-09 37.0 3.6 5e-09 36.6 3.6 1.2 1 0 0 1 1 1 1 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIC16323.1 - 1.4e-06 28.1 9.1 0.0012 18.8 0.6 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_9 PF13187.6 AIC16323.1 - 2.3e-06 27.7 3.3 6.2e-06 26.3 3.4 1.6 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_21 PF14697.6 AIC16323.1 - 2.9e-06 27.3 6.1 5.9e-06 26.3 6.1 1.5 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIC16323.1 - 1.6e-05 24.7 8.1 0.019 15.0 1.9 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 AIC16323.1 - 4.5e-05 23.9 4.5 0.06 13.9 0.5 2.3 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_16 PF13484.6 AIC16323.1 - 0.00015 22.6 5.9 0.072 14.0 0.2 2.1 2 0 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_10 PF13237.6 AIC16323.1 - 0.00027 21.0 9.0 0.011 15.8 9.7 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_4 PF12800.7 AIC16323.1 - 0.00048 20.4 6.7 0.17 12.5 1.8 2.2 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_22 PF17179.4 AIC16323.1 - 0.0015 19.3 2.3 0.5 11.3 0.5 2.1 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIC16323.1 - 0.0017 18.8 5.3 0.016 15.6 5.4 2.0 1 1 0 1 1 1 1 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIC16323.1 - 0.0037 18.1 12.1 0.28 12.2 4.3 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIC16323.1 - 0.043 14.6 10.4 0.31 11.8 1.9 2.8 1 1 1 2 2 2 0 4Fe-4S single cluster domain Fer4_17 PF13534.6 AIC16323.1 - 0.054 14.0 7.5 2.4 8.8 7.5 2.1 1 1 0 1 1 1 0 4Fe-4S dicluster domain AFP PF02420.15 AIC16323.1 - 0.15 12.4 0.4 0.15 12.4 0.4 2.4 3 0 0 3 3 2 0 Insect antifreeze protein repeat Fer4_18 PF13746.6 AIC16323.1 - 0.77 10.0 10.3 1.9 8.7 3.0 2.1 1 1 0 2 2 2 0 4Fe-4S dicluster domain AsnC_trans_reg PF01037.21 AIC16326.1 - 1.8e-12 47.1 0.1 1.8e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain GYD PF08734.11 AIC16326.1 - 0.00014 21.7 0.0 0.00016 21.6 0.0 1.2 1 0 0 1 1 1 1 GYD domain TP_methylase PF00590.20 AIC16327.1 - 1.2e-30 107.0 0.0 1.4e-30 106.8 0.0 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases PAC2 PF09754.9 AIC16328.1 - 2.6e-28 99.5 0.0 3e-28 99.3 0.0 1.0 1 0 0 1 1 1 1 PAC2 family Glycolipid_bind PF06475.11 AIC16329.1 - 3.6e-59 199.2 0.0 4.2e-59 199.0 0.0 1.0 1 0 0 1 1 1 1 Putative glycolipid-binding DUF4761 PF15958.5 AIC16330.1 - 0.18 12.0 0.0 14 5.8 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4761) ABM PF03992.16 AIC16331.1 - 8.2e-08 32.3 0.0 1e-07 31.9 0.0 1.1 1 0 0 1 1 1 1 Antibiotic biosynthesis monooxygenase SpoIIM PF01944.17 AIC16332.1 - 1.2e-07 31.9 5.9 1.7e-07 31.4 5.9 1.2 1 0 0 1 1 1 1 Stage II sporulation protein M DUF2628 PF10947.8 AIC16332.1 - 2.3 8.6 5.8 0.35 11.2 0.5 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2628) NDUF_B12 PF08122.12 AIC16332.1 - 2.6 8.2 6.9 1.7 8.8 0.4 2.9 3 0 0 3 3 3 0 NADH-ubiquinone oxidoreductase B12 subunit family Na_H_Exchanger PF00999.21 AIC16333.1 - 4.6e-59 200.1 53.0 5.8e-59 199.8 53.0 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Asp-Al_Ex PF06826.12 AIC16333.1 - 0.27 11.0 34.8 0.14 11.9 8.2 3.3 3 1 0 3 3 3 0 Predicted Permease Membrane Region MIP PF00230.20 AIC16334.1 - 4.5e-34 118.1 19.9 5.4e-34 117.9 19.9 1.0 1 0 0 1 1 1 1 Major intrinsic protein Papilloma_E5 PF03025.14 AIC16334.1 - 0.019 15.1 0.7 0.059 13.5 0.7 1.8 1 0 0 1 1 1 0 Papillomavirus E5 LMWPc PF01451.21 AIC16335.1 - 5.5e-21 75.4 0.0 9e-20 71.5 0.0 2.0 1 1 0 1 1 1 1 Low molecular weight phosphotyrosine protein phosphatase Methyltransf_31 PF13847.6 AIC16336.1 - 8.7e-33 113.3 0.0 1.4e-32 112.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC16336.1 - 4.5e-21 75.3 0.5 8.4e-21 74.4 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC16336.1 - 1.9e-20 73.3 0.1 1.9e-20 73.3 0.1 1.9 2 0 0 2 2 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC16336.1 - 5.5e-15 55.3 0.2 1.1e-14 54.4 0.2 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 AIC16336.1 - 1.6e-10 41.1 0.1 3.4e-10 40.0 0.1 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 AIC16336.1 - 9.4e-10 39.1 0.5 1.7e-09 38.3 0.0 1.7 2 0 0 2 2 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC16336.1 - 2.4e-09 37.3 0.0 3.5e-09 36.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AIC16336.1 - 1.1e-06 28.3 0.2 1.9e-06 27.5 0.2 1.3 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) CMAS PF02353.20 AIC16336.1 - 4.5e-05 22.9 0.0 6.1e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_8 PF05148.15 AIC16336.1 - 6.6e-05 22.9 0.0 0.00013 21.9 0.0 1.4 1 0 0 1 1 1 1 Hypothetical methyltransferase MTS PF05175.14 AIC16336.1 - 0.00011 21.8 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_32 PF13679.6 AIC16336.1 - 0.00019 21.5 0.0 0.00027 21.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 AIC16336.1 - 0.0014 17.9 0.0 0.72 9.0 0.0 2.1 2 0 0 2 2 2 2 NNMT/PNMT/TEMT family ADH_zinc_N PF00107.26 AIC16336.1 - 0.0042 17.0 0.2 0.0096 15.9 0.2 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase UPF0020 PF01170.18 AIC16336.1 - 0.0046 16.7 0.1 0.012 15.3 0.1 1.9 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 FtsJ PF01728.19 AIC16336.1 - 0.0092 16.1 0.0 0.021 14.9 0.0 1.7 1 1 0 1 1 1 1 FtsJ-like methyltransferase DOT1 PF08123.13 AIC16336.1 - 0.021 14.4 0.1 0.039 13.5 0.1 1.5 1 1 0 1 1 1 0 Histone methylation protein DOT1 Methyltransf_29 PF03141.16 AIC16336.1 - 0.044 12.4 0.0 0.057 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase GARS_C PF02843.16 AIC16336.1 - 0.047 14.0 0.1 0.31 11.3 0.0 2.1 2 0 0 2 2 2 0 Phosphoribosylglycinamide synthetase, C domain Methyltransf_4 PF02390.17 AIC16336.1 - 0.068 12.6 0.0 0.53 9.7 0.0 2.0 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_24 PF13578.6 AIC16336.1 - 0.086 13.9 0.0 0.18 12.8 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_15 PF09445.10 AIC16336.1 - 0.1 12.1 0.0 0.17 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase Methyltransf_18 PF12847.7 AIC16336.1 - 0.11 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain HxlR PF01638.17 AIC16337.1 - 1.1e-21 76.4 0.1 1.5e-21 76.0 0.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_34 PF13601.6 AIC16337.1 - 0.00015 21.9 0.0 0.00021 21.4 0.0 1.2 1 0 0 1 1 1 1 Winged helix DNA-binding domain PadR PF03551.14 AIC16337.1 - 0.0017 18.2 0.1 0.0025 17.7 0.1 1.3 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Replic_Relax PF13814.6 AIC16337.1 - 0.052 13.6 0.0 0.065 13.3 0.0 1.2 1 0 0 1 1 1 0 Replication-relaxation DUF2513 PF10711.9 AIC16337.1 - 0.16 12.3 0.0 0.21 11.9 0.0 1.2 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) RVT_3 PF13456.6 AIC16338.1 - 0.001 18.8 0.1 0.002 17.9 0.1 1.5 1 1 0 1 1 1 1 Reverse transcriptase-like RT_RNaseH PF17917.1 AIC16338.1 - 0.009 16.3 0.0 0.86 9.9 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH_2 PF17919.1 AIC16338.1 - 0.021 14.9 0.0 1.1 9.3 0.0 2.4 2 1 0 2 2 2 0 RNase H-like domain found in reverse transcriptase RNase_H PF00075.24 AIC16338.1 - 0.069 13.3 0.0 0.096 12.9 0.0 1.4 1 1 0 1 1 1 0 RNase H Pilus_CpaD PF09476.10 AIC16338.1 - 0.12 12.1 0.3 0.2 11.3 0.0 1.5 2 0 0 2 2 2 0 Pilus biogenesis CpaD protein (pilus_cpaD) DUF4817 PF16087.5 AIC16338.1 - 0.12 12.1 0.0 0.28 11.0 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain (DUF4817) CHAD PF05235.14 AIC16340.1 - 3.1e-21 76.4 10.5 1.2e-20 74.4 8.0 1.7 1 1 1 2 2 2 2 CHAD domain Thymidylate_kin PF02223.17 AIC16341.1 - 4.6e-20 72.1 0.0 6.6e-20 71.6 0.0 1.2 1 0 0 1 1 1 1 Thymidylate kinase AAA_17 PF13207.6 AIC16341.1 - 0.001 19.5 0.0 0.012 16.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain dNK PF01712.19 AIC16341.1 - 0.012 15.5 0.2 0.36 10.7 0.2 2.3 1 1 0 1 1 1 0 Deoxynucleoside kinase Thymidylate_kin PF02223.17 AIC16342.1 - 5.9e-22 78.2 0.0 1e-21 77.5 0.0 1.4 1 1 0 1 1 1 1 Thymidylate kinase AAA_18 PF13238.6 AIC16342.1 - 0.003 18.1 0.1 0.022 15.3 0.0 2.3 1 1 1 2 2 2 1 AAA domain dNK PF01712.19 AIC16342.1 - 0.0077 16.1 0.1 0.046 13.6 0.1 2.1 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_17 PF13207.6 AIC16342.1 - 0.0087 16.5 0.0 0.25 11.8 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 AIC16342.1 - 0.015 15.5 0.0 0.036 14.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 AIC16342.1 - 0.11 12.7 0.0 0.26 11.5 0.0 1.8 1 1 0 1 1 1 0 AAA domain PRK PF00485.18 AIC16342.1 - 0.12 12.1 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Ppx-GppA PF02541.16 AIC16343.1 - 2.3e-47 161.8 0.0 1.2e-46 159.4 0.0 1.9 1 1 0 1 1 1 1 Ppx/GppA phosphatase family PYST-C1 PF09690.10 AIC16343.1 - 0.93 9.3 10.2 2.3 8.1 10.2 1.6 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) His_Phos_1 PF00300.22 AIC16344.1 - 1.7e-14 54.0 0.0 1.4e-12 47.7 0.0 2.0 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Prok-RING_4 PF14447.6 AIC16346.1 - 0.0054 16.6 0.2 0.0077 16.1 0.2 1.3 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 AIC16346.1 - 0.026 14.4 0.1 0.038 13.8 0.1 1.2 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) HypA PF01155.19 AIC16346.1 - 0.088 12.8 0.1 0.095 12.7 0.1 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PBP_like_2 PF12849.7 AIC16347.1 - 2.1e-61 208.1 3.7 3.5e-61 207.4 3.7 1.3 1 0 0 1 1 1 1 PBP superfamily domain PBP_like PF12727.7 AIC16347.1 - 1.5e-09 37.3 0.0 4.8e-09 35.6 0.0 1.8 1 0 0 1 1 1 1 PBP superfamily domain PBP_like_2 PF12849.7 AIC16348.1 - 7e-55 186.7 5.4 7e-55 186.7 5.4 1.7 2 0 0 2 2 2 1 PBP superfamily domain SBP_bac_1 PF01547.25 AIC16348.1 - 3.4e-16 60.1 8.1 3.4e-16 60.1 8.1 1.9 2 0 0 2 2 2 1 Bacterial extracellular solute-binding protein PBP_like PF12727.7 AIC16348.1 - 1e-07 31.3 0.0 3.1e-07 29.7 0.0 1.7 1 1 0 1 1 1 1 PBP superfamily domain Hydin_ADK PF17213.3 AIC16348.1 - 0.17 12.2 1.4 0.28 11.4 1.4 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain BPD_transp_1 PF00528.22 AIC16349.1 - 4.5e-17 62.4 20.9 4.5e-17 62.4 20.9 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component BPD_transp_1 PF00528.22 AIC16350.1 - 7.4e-18 64.9 17.9 7.4e-18 64.9 17.9 2.1 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component DUF3333 PF11812.8 AIC16350.1 - 0.0011 19.2 2.4 0.015 15.5 0.0 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3333) COX14 PF14880.6 AIC16350.1 - 0.026 14.4 0.0 0.096 12.5 0.0 2.0 1 0 0 1 1 1 0 Cytochrome oxidase c assembly ABC_tran PF00005.27 AIC16351.1 - 1.7e-30 106.3 0.0 2.4e-30 105.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC16351.1 - 2.2e-10 40.8 0.0 9.5e-05 22.3 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIC16351.1 - 1.9e-09 37.3 0.2 3.2e-08 33.3 0.2 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 AIC16351.1 - 1.6e-05 25.2 0.0 0.00012 22.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AIC16351.1 - 0.00016 21.5 0.0 0.00052 19.8 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 AIC16351.1 - 0.00021 21.2 0.1 0.00044 20.2 0.0 1.5 2 0 0 2 2 1 1 RsgA GTPase AAA PF00004.29 AIC16351.1 - 0.00032 21.1 0.3 0.0048 17.3 0.3 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 AIC16351.1 - 0.0013 18.7 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 AIC16351.1 - 0.0014 19.1 0.1 0.0025 18.2 0.1 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 AIC16351.1 - 0.0014 18.3 0.3 0.021 14.6 0.1 2.0 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 AIC16351.1 - 0.0016 18.1 0.0 0.0027 17.4 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_28 PF13521.6 AIC16351.1 - 0.0022 18.3 0.0 0.0049 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIC16351.1 - 0.0027 18.2 0.0 0.0064 17.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AIC16351.1 - 0.0027 18.2 0.2 0.0065 17.0 0.2 1.9 1 1 0 1 1 1 1 AAA domain TniB PF05621.11 AIC16351.1 - 0.0041 16.6 0.1 1.3 8.4 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein ATPase_2 PF01637.18 AIC16351.1 - 0.0082 16.1 0.1 0.26 11.2 0.0 2.2 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA_33 PF13671.6 AIC16351.1 - 0.015 15.4 0.0 0.027 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 AIC16351.1 - 0.026 14.5 0.0 0.054 13.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) NB-ARC PF00931.22 AIC16351.1 - 0.026 13.7 0.0 0.035 13.3 0.0 1.3 1 1 0 1 1 1 0 NB-ARC domain PduV-EutP PF10662.9 AIC16351.1 - 0.03 14.1 0.1 0.061 13.1 0.1 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_24 PF13479.6 AIC16351.1 - 0.032 14.0 0.3 0.093 12.4 0.0 1.9 3 0 0 3 3 2 0 AAA domain AAA_7 PF12775.7 AIC16351.1 - 0.036 13.6 0.1 0.064 12.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 AIC16351.1 - 0.045 13.5 0.0 0.08 12.7 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase ABC_ATPase PF09818.9 AIC16351.1 - 0.061 12.1 0.2 0.82 8.4 0.0 2.0 2 0 0 2 2 2 0 Predicted ATPase of the ABC class RNA_helicase PF00910.22 AIC16351.1 - 0.08 13.3 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 AIC16351.1 - 0.09 12.3 0.1 0.25 10.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 AIC16351.1 - 0.11 12.3 0.1 0.56 9.9 0.0 1.9 2 0 0 2 2 2 0 IstB-like ATP binding protein NACHT PF05729.12 AIC16351.1 - 0.11 12.5 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 NACHT domain TsaE PF02367.17 AIC16351.1 - 0.11 12.5 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP-synt_ab PF00006.25 AIC16351.1 - 0.14 11.8 0.1 0.36 10.5 0.1 1.6 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain cobW PF02492.19 AIC16351.1 - 0.16 11.5 0.4 0.38 10.3 0.1 1.7 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain PhoU PF01895.19 AIC16352.1 - 6.5e-32 109.9 3.7 2e-19 69.8 0.4 2.1 2 0 0 2 2 2 2 PhoU domain Pil1 PF13805.6 AIC16352.1 - 0.0019 17.7 0.4 0.0074 15.8 0.0 1.8 2 0 0 2 2 2 1 Eisosome component PIL1 Peptidase_M19 PF01244.21 AIC16352.1 - 0.015 14.4 0.1 0.054 12.6 0.0 1.7 2 0 0 2 2 2 0 Membrane dipeptidase (Peptidase family M19) DUF2034 PF10356.9 AIC16352.1 - 0.038 13.4 0.0 0.05 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2034) DUF1771 PF08590.10 AIC16352.1 - 0.055 13.9 0.3 0.36 11.2 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1771) PhoU PF01895.19 AIC16353.1 - 7.9e-22 77.5 7.5 6e-17 61.9 1.6 2.7 2 0 0 2 2 2 2 PhoU domain MazE_antitoxin PF04014.18 AIC16353.1 - 4.2e-05 23.4 0.0 0.00019 21.3 0.0 2.0 2 0 0 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin Neur_chan_memb PF02932.16 AIC16354.1 - 4.8e-05 23.5 4.3 8.4e-05 22.7 4.3 1.5 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region N6_N4_Mtase PF01555.18 AIC16355.1 - 9.1e-23 81.2 0.1 3.4e-13 49.9 0.0 2.1 2 0 0 2 2 2 2 DNA methylase Dev_Cell_Death PF10539.9 AIC16355.1 - 2.5e-18 66.2 0.0 4.2e-18 65.4 0.0 1.3 1 0 0 1 1 1 1 Development and cell death domain Methyltransf_11 PF08241.12 AIC16355.1 - 4e-07 30.6 0.0 6.1e-06 26.8 0.0 2.3 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 AIC16355.1 - 3.9e-05 23.4 0.1 0.13 11.9 0.0 2.5 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 Methyltransf_8 PF05148.15 AIC16355.1 - 0.00027 20.8 0.1 0.00081 19.3 0.0 1.7 2 0 0 2 2 2 1 Hypothetical methyltransferase Methyltransf_25 PF13649.6 AIC16355.1 - 0.0016 19.1 0.1 0.038 14.7 0.1 2.9 1 1 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AIC16355.1 - 0.13 11.8 0.0 5.3 6.6 0.1 2.2 1 1 1 2 2 2 0 Conserved hypothetical protein 95 AviRa PF11599.8 AIC16355.1 - 0.14 11.6 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa zf-B_box PF00643.24 AIC16356.1 - 0.0015 18.6 7.1 0.0015 18.6 7.1 1.9 2 0 0 2 2 2 1 B-box zinc finger C6_DPF PF10170.9 AIC16356.1 - 0.054 13.9 3.4 0.054 13.9 3.4 1.6 1 1 1 2 2 2 0 Cysteine-rich domain zf-C3HC4_3 PF13920.6 AIC16356.1 - 0.29 11.0 12.1 0.79 9.6 12.2 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FYVE_2 PF02318.16 AIC16356.1 - 0.65 10.2 8.7 1.1 9.5 8.7 1.6 1 1 0 1 1 1 0 FYVE-type zinc finger DUF4428 PF14471.6 AIC16356.1 - 2.9 7.9 10.6 12 6.0 5.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4428) NUDIX PF00293.28 AIC16357.1 - 1.8e-15 57.1 0.0 2.6e-15 56.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain MarR_2 PF12802.7 AIC16358.1 - 4.1e-05 23.4 0.0 7.4e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_45 PF14947.6 AIC16358.1 - 0.055 13.4 0.4 0.094 12.7 0.4 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix Rio2_N PF09202.11 AIC16358.1 - 0.067 13.4 0.1 0.22 11.8 0.0 1.7 2 0 0 2 2 2 0 Rio2, N-terminal NikR_C PF08753.11 AIC16360.1 - 2.1e-14 53.4 1.1 3.1e-14 52.9 1.1 1.3 1 0 0 1 1 1 1 NikR C terminal nickel binding domain RHH_1 PF01402.21 AIC16360.1 - 1.1e-06 28.3 0.1 2.1e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family VapB_antitoxin PF09957.9 AIC16360.1 - 0.0055 16.6 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial antitoxin of type II TA system, VapB NikR_C PF08753.11 AIC16361.1 - 1.6e-13 50.6 0.3 2.3e-13 50.1 0.3 1.2 1 0 0 1 1 1 1 NikR C terminal nickel binding domain RHH_1 PF01402.21 AIC16361.1 - 0.035 14.0 0.4 0.13 12.2 0.0 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family ZnuA PF01297.17 AIC16362.1 - 3.1e-75 252.9 0.0 3.6e-75 252.7 0.0 1.0 1 0 0 1 1 1 1 Zinc-uptake complex component A periplasmic ABC_tran PF00005.27 AIC16363.1 - 3e-33 115.2 0.0 1.4e-32 113.1 0.0 1.8 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 AIC16363.1 - 2.4e-13 50.6 1.7 8.5e-07 29.1 0.0 2.1 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 AIC16363.1 - 3.2e-09 37.6 0.3 5.4e-09 36.8 0.3 1.5 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 AIC16363.1 - 9.2e-06 25.2 0.4 0.021 14.3 0.1 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 AIC16363.1 - 9.1e-05 22.3 0.2 0.16 11.6 0.2 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_29 PF13555.6 AIC16363.1 - 0.00028 20.6 0.2 0.00058 19.5 0.2 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 AIC16363.1 - 0.00029 21.3 0.7 0.0015 18.9 0.7 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 AIC16363.1 - 0.0019 17.4 0.2 0.42 9.8 0.1 2.0 2 0 0 2 2 2 2 NB-ARC domain AAA_27 PF13514.6 AIC16363.1 - 0.0045 16.6 0.0 0.0079 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC16363.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 AIC16363.1 - 0.031 13.3 0.2 0.22 10.5 0.1 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein SbcCD_C PF13558.6 AIC16363.1 - 0.065 13.5 0.1 1.9 8.8 0.1 2.2 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit MMR_HSR1 PF01926.23 AIC16363.1 - 0.074 13.1 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 AIC16363.1 - 0.09 12.7 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 AIC16363.1 - 0.095 12.1 0.0 0.33 10.3 0.0 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 AIC16363.1 - 0.098 12.4 0.0 0.24 11.1 0.0 1.9 1 1 0 1 1 1 0 AAA domain PhoH PF02562.16 AIC16363.1 - 0.11 12.0 1.0 1.1 8.7 0.0 2.6 2 1 2 4 4 4 0 PhoH-like protein RsgA_GTPase PF03193.16 AIC16363.1 - 0.11 12.4 0.1 0.45 10.4 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 AIC16363.1 - 0.11 12.6 0.1 0.2 11.8 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 AIC16363.1 - 0.13 12.6 0.2 1.5 9.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AIC16363.1 - 0.16 12.2 0.9 1.1 9.5 0.1 2.1 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AIC16363.1 - 0.18 11.7 0.2 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 NACHT domain ABC-3 PF00950.17 AIC16364.1 - 3.9e-65 219.9 38.6 4.4e-65 219.7 38.6 1.0 1 0 0 1 1 1 1 ABC 3 transport family FecCD PF01032.18 AIC16364.1 - 8.4e-10 38.1 35.8 9.3e-10 38.0 30.4 2.1 1 1 1 2 2 2 2 FecCD transport family CD20 PF04103.15 AIC16364.1 - 0.00085 19.4 8.0 0.00085 19.4 8.0 3.3 1 1 2 3 3 3 1 CD20-like family DUF4466 PF14725.6 AIC16365.1 - 0.042 13.3 0.1 0.047 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4466) zf-C5HC2 PF02928.16 AIC16366.1 - 0.11 12.9 0.5 0.18 12.3 0.5 1.4 1 0 0 1 1 1 0 C5HC2 zinc finger Glyco_tran_28_C PF04101.16 AIC16367.1 - 1.2e-11 44.9 0.0 2e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain Glyco_trans_1_3 PF13528.6 AIC16367.1 - 0.00061 19.1 0.0 0.14 11.4 0.0 2.2 2 0 0 2 2 2 2 Glycosyl transferase family 1 Kelch_1 PF01344.25 AIC16370.1 - 2.1e-61 203.3 1.7 2.4e-11 43.0 0.0 6.5 6 0 0 6 6 6 6 Kelch motif Kelch_6 PF13964.6 AIC16370.1 - 3.1e-42 141.5 4.9 4.1e-11 42.8 0.0 7.3 3 2 4 7 7 7 6 Kelch motif Kelch_2 PF07646.15 AIC16370.1 - 8.5e-33 111.1 0.0 0.0001 22.1 0.0 6.5 7 0 0 7 7 7 6 Kelch motif Kelch_3 PF13415.6 AIC16370.1 - 5.8e-29 99.8 17.1 2.8e-08 33.8 0.1 7.3 7 1 0 7 7 7 5 Galactose oxidase, central domain Kelch_4 PF13418.6 AIC16370.1 - 1.5e-26 92.1 2.7 7.6e-08 32.2 0.0 6.5 6 0 0 6 6 6 5 Galactose oxidase, central domain Kelch_5 PF13854.6 AIC16370.1 - 7.2e-26 89.7 8.9 0.00046 20.1 0.0 6.2 6 0 0 6 6 6 6 Kelch motif DUF1668 PF07893.13 AIC16370.1 - 0.00011 21.7 0.1 0.28 10.5 0.1 3.3 2 1 1 3 3 3 2 Protein of unknown function (DUF1668) BA14K PF07886.11 AIC16370.1 - 0.63 10.0 1.7 2.9 7.9 0.0 2.7 3 0 0 3 3 3 0 BA14K-like protein Zn-ribbon_8 PF09723.10 AIC16371.1 - 0.0085 16.2 3.0 0.64 10.2 0.2 2.1 2 0 0 2 2 2 2 Zinc ribbon domain C1_1 PF00130.22 AIC16371.1 - 0.031 14.2 2.2 0.037 13.9 1.4 1.5 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) A2L_zn_ribbon PF08792.10 AIC16371.1 - 0.072 12.8 4.1 4.4 7.1 0.2 2.4 2 0 0 2 2 2 0 A2L zinc ribbon domain Desulfoferrod_N PF06397.12 AIC16371.1 - 0.084 12.5 0.7 0.084 12.5 0.7 2.2 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain Zn_Tnp_IS91 PF14319.6 AIC16371.1 - 0.18 11.9 2.8 0.47 10.5 2.2 1.7 1 1 0 1 1 1 0 Transposase zinc-binding domain DUF2470 PF10615.9 AIC16372.1 - 0.03 15.0 0.1 0.11 13.1 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2470) AA_kinase PF00696.28 AIC16373.1 - 1.2e-25 90.5 0.3 2e-25 89.8 0.3 1.4 1 0 0 1 1 1 1 Amino acid kinase family Aminotran_4 PF01063.19 AIC16374.1 - 1.9e-48 165.3 0.0 2.2e-48 165.1 0.0 1.0 1 0 0 1 1 1 1 Amino-transferase class IV DUF3944 PF13099.6 AIC16374.1 - 0.017 15.0 0.0 0.037 13.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) MoCF_biosynth PF00994.24 AIC16376.1 - 2.2e-35 121.4 0.1 3e-35 121.0 0.1 1.2 1 0 0 1 1 1 1 Probable molybdopterin binding domain Metallophos_3 PF14582.6 AIC16376.1 - 0.04 13.3 0.3 3.4 6.9 0.1 2.2 1 1 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily CinA_KH PF18146.1 AIC16376.1 - 0.1 12.8 0.1 0.49 10.6 0.0 2.2 2 1 0 2 2 2 0 Damage-inducible protein CinA KH domain eIF-6 PF01912.18 AIC16377.1 - 5.1e-65 218.6 0.2 6e-65 218.3 0.2 1.1 1 0 0 1 1 1 1 eIF-6 family Protocadherin PF08374.11 AIC16378.1 - 0.021 14.8 0.0 0.026 14.5 0.0 1.0 1 0 0 1 1 1 0 Protocadherin TMEM51 PF15345.6 AIC16378.1 - 0.029 14.2 0.1 0.033 14.0 0.1 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 DUF1691 PF07950.11 AIC16378.1 - 0.068 13.9 0.4 0.083 13.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1691) F420_oxidored PF03807.17 AIC16379.1 - 2e-15 57.1 0.2 2.9e-15 56.6 0.2 1.2 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 AIC16379.1 - 2.9e-05 24.3 0.0 4.5e-05 23.7 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Shikimate_DH PF01488.20 AIC16379.1 - 0.0025 17.9 0.0 0.0037 17.3 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Rossmann-like PF10727.9 AIC16379.1 - 0.024 14.5 0.5 0.16 11.8 0.1 2.3 2 1 0 2 2 2 0 Rossmann-like domain 3HCDH_N PF02737.18 AIC16379.1 - 0.034 14.0 0.3 0.045 13.6 0.3 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIC16379.1 - 0.042 13.2 0.1 0.059 12.7 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ApbA PF02558.16 AIC16379.1 - 0.05 13.2 0.2 0.1 12.2 0.2 1.5 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 AIC16379.1 - 0.088 12.4 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain NAD_binding_10 PF13460.6 AIC16379.1 - 0.12 12.3 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 NAD(P)H-binding UDPG_MGDP_dh_N PF03721.14 AIC16379.1 - 0.19 11.3 0.0 0.72 9.4 0.1 1.8 2 0 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain HicA_toxin PF07927.12 AIC16382.1 - 5.7e-17 61.5 0.1 7e-17 61.2 0.1 1.1 1 0 0 1 1 1 1 HicA toxin of bacterial toxin-antitoxin, HicB_lk_antitox PF15919.5 AIC16383.1 - 7.3e-10 39.0 0.0 7.9e-10 38.9 0.0 1.1 1 0 0 1 1 1 1 HicB_like antitoxin of bacterial toxin-antitoxin system DUF1902 PF08972.11 AIC16383.1 - 0.0037 17.2 0.0 0.0044 17.0 0.0 1.2 1 1 0 1 1 1 1 Domain of unknown function (DUF1902) GAS PF13851.6 AIC16383.1 - 0.017 14.5 0.1 0.02 14.2 0.1 1.0 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4854 PF16146.5 AIC16383.1 - 0.038 14.3 0.3 0.058 13.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4854) COG2 PF06148.11 AIC16383.1 - 0.079 13.0 0.0 0.091 12.9 0.0 1.0 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 PHD_like PF12910.7 AIC16383.1 - 0.08 13.0 0.1 0.096 12.7 0.1 1.2 1 0 0 1 1 1 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system OTCace_N PF02729.21 AIC16384.1 - 5.3e-42 143.3 0.0 9.4e-42 142.5 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 AIC16384.1 - 1.1e-30 106.8 0.0 1.5e-30 106.3 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Methyltransf_3 PF01596.17 AIC16385.1 - 2.4e-34 118.4 0.2 8.7e-34 116.6 0.2 1.7 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 AIC16385.1 - 3.3e-16 60.2 0.0 5.4e-16 59.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC16385.1 - 7e-11 42.2 0.0 9.4e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AIC16385.1 - 7.4e-08 32.4 0.0 1.1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_25 PF13649.6 AIC16385.1 - 2e-07 31.6 0.0 3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain GCD14 PF08704.10 AIC16385.1 - 8.2e-05 22.4 0.0 0.00012 21.9 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.12 AIC16385.1 - 0.00029 21.4 0.0 0.00053 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 AIC16385.1 - 0.00046 19.8 0.0 0.0008 19.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltr_RsmB-F PF01189.17 AIC16385.1 - 0.0015 18.2 0.1 0.0025 17.5 0.1 1.3 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltransf_18 PF12847.7 AIC16385.1 - 0.0023 17.9 0.0 0.0048 16.8 0.0 1.5 2 0 0 2 2 2 1 Methyltransferase domain Cons_hypoth95 PF03602.15 AIC16385.1 - 0.016 14.8 0.2 0.052 13.2 0.0 1.7 1 1 1 2 2 2 0 Conserved hypothetical protein 95 Ubie_methyltran PF01209.18 AIC16385.1 - 0.02 14.2 0.0 0.025 13.9 0.0 1.4 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family CmcI PF04989.12 AIC16385.1 - 0.021 14.5 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Cephalosporin hydroxylase PrmA PF06325.13 AIC16385.1 - 0.027 13.9 0.1 0.035 13.5 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 AIC16385.1 - 0.034 13.8 0.0 0.049 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_23 PF13489.6 AIC16385.1 - 0.091 12.6 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain MazE_antitoxin PF04014.18 AIC16387.1 - 1.7e-10 40.6 1.3 2.5e-10 40.1 1.3 1.3 1 0 0 1 1 1 1 Antidote-toxin recognition MazE, bacterial antitoxin PrlF_antitoxin PF15937.5 AIC16387.1 - 0.00062 20.2 0.1 0.00087 19.7 0.1 1.4 1 1 0 1 1 1 1 prlF antitoxin for toxin YhaV_toxin Dak1_2 PF13684.6 AIC16387.1 - 0.015 14.4 0.3 0.017 14.2 0.3 1.0 1 0 0 1 1 1 0 Dihydroxyacetone kinase family DUF2375 PF09558.10 AIC16387.1 - 0.06 13.4 0.8 0.14 12.2 0.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2375) AbrB-like PF14250.6 AIC16387.1 - 0.087 12.9 0.0 0.12 12.5 0.0 1.2 1 0 0 1 1 1 0 AbrB-like transcriptional regulator PemK_toxin PF02452.17 AIC16388.1 - 6.2e-18 65.2 0.5 6.8e-18 65.1 0.5 1.0 1 0 0 1 1 1 1 PemK-like, MazF-like toxin of type II toxin-antitoxin system DDE_Tnp_IS240 PF13610.6 AIC16390.1 - 2.3e-10 40.8 0.1 3.7e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 DDE domain PIN PF01850.21 AIC16391.1 - 1e-08 35.7 0.9 1.2e-08 35.5 0.9 1.1 1 0 0 1 1 1 1 PIN domain CcdA PF07362.12 AIC16392.1 - 0.0085 16.5 0.0 0.011 16.2 0.0 1.2 1 0 0 1 1 1 1 Post-segregation antitoxin CcdA RHH_3 PF12651.7 AIC16392.1 - 0.075 13.0 0.8 0.6 10.1 0.2 2.5 2 1 0 2 2 2 0 Ribbon-helix-helix domain HATPase_c PF02518.26 AIC16393.1 - 4.5e-31 107.6 0.0 1.3e-30 106.1 0.0 1.9 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase dCache_1 PF02743.18 AIC16393.1 - 2.2e-25 89.9 0.2 7.1e-25 88.2 0.2 1.9 2 0 0 2 2 2 1 Cache domain HisKA PF00512.25 AIC16393.1 - 3.2e-14 52.7 0.2 3.2e-14 52.7 0.2 3.4 3 1 1 4 4 4 1 His Kinase A (phospho-acceptor) domain GAPES1 PF17155.4 AIC16393.1 - 0.00028 20.3 0.1 0.00051 19.5 0.1 1.3 1 0 0 1 1 1 1 Gammaproteobacterial periplasmic sensor domain HATPase_c_5 PF14501.6 AIC16393.1 - 0.04 13.8 0.0 0.15 12.0 0.0 2.0 1 0 0 1 1 1 0 GHKL domain HATPase_c_3 PF13589.6 AIC16393.1 - 0.098 12.5 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Fez1 PF06818.15 AIC16393.1 - 0.14 12.6 3.8 0.051 14.0 0.9 1.7 2 0 0 2 2 2 0 Fez1 HemX PF04375.14 AIC16393.1 - 0.47 9.7 9.4 0.079 12.2 3.6 2.3 2 1 1 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase ATG16 PF08614.11 AIC16393.1 - 1.2 9.4 13.4 0.062 13.5 7.1 1.9 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 AIC16393.1 - 2.3 7.0 11.7 0.23 10.3 6.8 1.8 2 0 0 2 2 2 0 Spc7 kinetochore protein Response_reg PF00072.24 AIC16394.1 - 3e-22 78.9 0.1 3.4e-22 78.7 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain Response_reg PF00072.24 AIC16395.1 - 8.6e-20 71.0 0.1 9.8e-20 70.8 0.1 1.0 1 0 0 1 1 1 1 Response regulator receiver domain FleQ PF06490.11 AIC16395.1 - 0.0049 17.2 0.0 0.0073 16.7 0.0 1.2 1 0 0 1 1 1 1 Flagellar regulatory protein FleQ HATPase_c PF02518.26 AIC16396.1 - 2.8e-27 95.4 0.0 7.4e-27 94.1 0.0 1.7 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HAMP PF00672.25 AIC16396.1 - 4.7e-15 55.7 0.1 1.3e-14 54.3 0.1 1.8 1 0 0 1 1 1 1 HAMP domain dCache_1 PF02743.18 AIC16396.1 - 9.6e-07 28.8 0.1 1.6e-06 28.1 0.1 1.3 1 0 0 1 1 1 1 Cache domain HisKA PF00512.25 AIC16396.1 - 5.5e-05 23.1 0.0 0.00013 21.9 0.0 1.7 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_5 PF14501.6 AIC16396.1 - 0.00021 21.1 0.0 0.00049 20.0 0.0 1.6 1 0 0 1 1 1 1 GHKL domain DUF948 PF06103.11 AIC16396.1 - 1.9 8.8 5.8 7.5 6.9 0.9 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Peptidase_M10 PF00413.24 AIC16397.1 - 4.3e-06 26.7 0.1 6.7e-06 26.0 0.1 1.6 1 1 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 AIC16397.1 - 0.00065 20.2 0.0 0.0013 19.2 0.0 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Peptidase_M66 PF10462.9 AIC16397.1 - 0.0068 15.4 0.3 0.013 14.5 0.3 1.3 1 0 0 1 1 1 1 Peptidase M66 Peptidase_M57 PF12388.8 AIC16397.1 - 0.015 14.9 0.5 0.034 13.8 0.1 1.8 2 0 0 2 2 2 0 Dual-action HEIGH metallo-peptidase Metallopep PF12044.8 AIC16397.1 - 0.042 12.4 0.2 0.069 11.7 0.0 1.4 2 0 0 2 2 2 0 Putative peptidase family Peptidase_M54 PF07998.11 AIC16397.1 - 0.12 12.3 0.1 0.45 10.5 0.1 1.9 1 1 1 2 2 2 0 Peptidase family M54 NTP_transf_5 PF14907.6 AIC16398.1 - 2.6e-06 27.2 0.0 3.8e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised nucleotidyltransferase ALO PF04030.14 AIC16399.1 - 0.13 12.0 0.0 5.2 6.8 0.0 2.1 2 0 0 2 2 2 0 D-arabinono-1,4-lactone oxidase PsiB PF06290.11 AIC16399.1 - 0.19 11.2 0.3 0.72 9.3 0.0 1.9 2 0 0 2 2 2 0 Plasmid SOS inhibition protein (PsiB) PrlF_antitoxin PF15937.5 AIC16401.1 - 0.0069 16.8 0.0 0.0079 16.6 0.0 1.2 1 0 0 1 1 1 1 prlF antitoxin for toxin YhaV_toxin MazE_antitoxin PF04014.18 AIC16401.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin DDE_Tnp_IS240 PF13610.6 AIC16403.1 - 4.2e-21 75.6 2.2 4.2e-21 75.6 2.2 1.6 2 0 0 2 2 2 1 DDE domain rve PF00665.26 AIC16403.1 - 8.6e-08 32.4 0.1 1.9e-07 31.3 0.1 1.5 1 0 0 1 1 1 1 Integrase core domain SWIM PF04434.17 AIC16403.1 - 0.00034 20.2 0.2 0.00076 19.1 0.2 1.6 1 0 0 1 1 1 1 SWIM zinc finger rve_3 PF13683.6 AIC16403.1 - 0.0011 18.8 0.0 0.0027 17.5 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain zf-SNAP50_C PF12251.8 AIC16403.1 - 0.066 12.9 0.7 0.12 12.1 0.7 1.4 1 0 0 1 1 1 0 snRNA-activating protein of 50kDa MW C terminal Herpes_UL3 PF03369.13 AIC16403.1 - 0.13 12.8 0.2 0.94 10.0 0.0 2.2 2 0 0 2 2 2 0 Herpesvirus UL3 protein C1_4 PF07975.12 AIC16403.1 - 2 8.7 4.3 1.7 8.9 1.6 2.1 2 0 0 2 2 2 0 TFIIH C1-like domain DUF4430 PF14478.6 AIC16404.1 - 0.24 12.0 1.8 1.2 9.8 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4430) Cdc6_C PF09079.11 AIC16405.1 - 4.9e-12 45.7 0.3 1.2e-11 44.4 0.1 1.8 2 0 0 2 2 2 1 CDC6, C terminal winged helix domain AAA_16 PF13191.6 AIC16405.1 - 2.5e-07 31.3 0.6 4.9e-05 23.8 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AIC16405.1 - 1.1e-06 28.9 0.0 2.9e-06 27.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AIC16405.1 - 1.7e-06 28.5 0.0 4.8e-06 27.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 AIC16405.1 - 8.8e-06 25.8 1.0 0.00013 22.0 0.3 2.6 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea DUF815 PF05673.13 AIC16405.1 - 0.018 14.2 0.0 0.058 12.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 AIC16405.1 - 0.036 14.6 0.0 0.13 12.8 0.0 1.9 1 0 0 1 1 1 0 ABC transporter ORC5_C PF14630.6 AIC16405.1 - 0.04 13.4 0.0 0.52 9.8 0.1 2.3 1 1 1 2 2 2 0 Origin recognition complex (ORC) subunit 5 C-terminus AAA_33 PF13671.6 AIC16405.1 - 0.05 13.8 0.0 0.19 11.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain Ploopntkinase1 PF18748.1 AIC16405.1 - 0.075 12.6 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase1 RNA_helicase PF00910.22 AIC16405.1 - 0.17 12.3 0.0 0.54 10.7 0.0 1.9 1 0 0 1 1 1 0 RNA helicase RsgA_GTPase PF03193.16 AIC16405.1 - 0.2 11.5 0.2 1 9.3 0.0 2.2 2 1 0 2 2 2 0 RsgA GTPase Fapy_DNA_glyco PF01149.24 AIC16406.1 - 0.047 14.3 0.3 0.66 10.6 0.0 2.0 2 0 0 2 2 2 0 Formamidopyrimidine-DNA glycosylase N-terminal domain PIN PF01850.21 AIC16407.1 - 3.5e-14 53.3 0.4 3.9e-14 53.2 0.4 1.0 1 0 0 1 1 1 1 PIN domain PIN_3 PF13470.6 AIC16407.1 - 0.059 14.1 1.0 0.088 13.6 1.0 1.3 1 1 0 1 1 1 0 PIN domain VAPB_antitox PF02697.14 AIC16408.1 - 8e-20 71.4 1.3 9e-20 71.2 1.3 1.0 1 0 0 1 1 1 1 Putative antitoxin TetR_C_16 PF17920.1 AIC16408.1 - 0.027 14.7 0.1 0.032 14.5 0.1 1.1 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain NTP_transf_5 PF14907.6 AIC16411.1 - 0.0029 17.3 0.1 0.01 15.5 0.1 1.8 1 1 0 1 1 1 1 Uncharacterised nucleotidyltransferase AbiEii PF08843.11 AIC16411.1 - 0.011 15.6 0.9 0.02 14.9 0.9 1.4 1 1 0 1 1 1 0 Nucleotidyl transferase AbiEii toxin, Type IV TA system DUF2204 PF09970.9 AIC16411.1 - 0.014 15.1 2.3 0.024 14.3 2.3 1.5 1 1 0 1 1 1 0 Nucleotidyl transferase of unknown function (DUF2204) DUF4032 PF13224.6 AIC16413.1 - 0.034 14.0 0.5 0.034 14.0 0.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4032) HTH_25 PF13413.6 AIC16413.1 - 0.047 13.6 0.3 0.2 11.5 0.3 2.2 1 0 0 1 1 1 0 Helix-turn-helix domain Ntox28 PF15605.6 AIC16413.1 - 0.092 13.0 1.4 7.4 6.9 0.0 3.3 3 1 0 3 3 3 0 Bacterial toxin 28 Noelin-1 PF12308.8 AIC16413.1 - 0.14 12.1 4.0 0.37 10.8 0.1 3.5 2 1 2 4 4 4 0 Neurogenesis glycoprotein DUF4065 PF13274.6 AIC16413.1 - 0.19 12.6 5.1 2.6 9.0 0.0 3.1 2 2 2 4 4 4 0 Protein of unknown function (DUF4065) Syntaxin_2 PF14523.6 AIC16413.1 - 0.27 11.6 11.1 0.046 14.1 1.1 3.6 3 2 0 3 3 3 0 Syntaxin-like protein DUF2150 PF09920.9 AIC16414.1 - 0.002 18.1 0.3 0.0032 17.5 0.3 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2150) HALZ PF02183.18 AIC16414.1 - 0.012 15.8 0.8 0.012 15.8 0.8 2.2 3 0 0 3 3 3 0 Homeobox associated leucine zipper AviRa PF11599.8 AIC16414.1 - 0.048 13.1 0.1 0.054 12.9 0.1 1.1 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Inositol_P PF00459.25 AIC16414.1 - 0.098 12.2 0.2 0.12 11.9 0.2 1.1 1 0 0 1 1 1 0 Inositol monophosphatase family Polbeta PF18765.1 AIC16415.1 - 5.6e-09 36.0 1.5 9.9e-09 35.2 0.7 1.8 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 AIC16415.1 - 1.5e-06 28.4 0.2 2.6e-06 27.6 0.2 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain Rrf2 PF02082.20 AIC16415.1 - 1.8e-05 25.0 0.0 3.8e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 Transcriptional regulator TrmB PF01978.19 AIC16415.1 - 0.0015 18.4 0.0 0.0031 17.3 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIC16415.1 - 0.0032 17.9 0.0 0.0081 16.6 0.0 1.7 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_24 PF13412.6 AIC16415.1 - 0.0049 16.4 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding IF2_N PF04760.15 AIC16415.1 - 0.0051 16.6 0.1 0.047 13.5 0.0 2.7 3 0 0 3 3 3 1 Translation initiation factor IF-2, N-terminal region HTH_IclR PF09339.10 AIC16415.1 - 0.0054 16.5 0.1 0.01 15.6 0.1 1.4 1 0 0 1 1 1 1 IclR helix-turn-helix domain DUF1495 PF07381.11 AIC16415.1 - 0.0058 16.4 0.1 0.046 13.5 0.1 2.2 1 1 0 1 1 1 1 Winged helix DNA-binding domain (DUF1495) DUF4423 PF14394.6 AIC16415.1 - 0.0063 16.2 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) GntR PF00392.21 AIC16415.1 - 0.016 14.8 0.0 0.051 13.2 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family MarR_2 PF12802.7 AIC16415.1 - 0.02 14.8 0.0 0.04 13.8 0.0 1.5 1 0 0 1 1 1 0 MarR family HTH_29 PF13551.6 AIC16415.1 - 0.021 14.8 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn helix HTH_Crp_2 PF13545.6 AIC16415.1 - 0.024 14.6 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain RPA_C PF08784.11 AIC16415.1 - 0.033 14.8 0.0 0.059 14.0 0.0 1.4 1 0 0 1 1 1 0 Replication protein A C terminal HTH_5 PF01022.20 AIC16415.1 - 0.041 13.8 0.1 0.083 12.8 0.1 1.6 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC16415.1 - 0.046 13.8 0.2 0.13 12.4 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Dimerisation2 PF16864.5 AIC16415.1 - 0.067 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Dimerisation domain SMODS PF18144.1 AIC16415.1 - 0.1 12.8 0.2 0.23 11.6 0.1 1.6 1 1 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain FeoC PF09012.10 AIC16415.1 - 0.11 12.6 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 FeoC like transcriptional regulator HEPN PF05168.14 AIC16416.1 - 1.3e-09 38.2 0.4 1.7e-09 37.8 0.4 1.1 1 0 0 1 1 1 1 HEPN domain Neur_chan_memb PF02932.16 AIC16417.1 - 8.6e-06 26.0 5.1 1.3e-05 25.4 5.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Neur_chan_LBD PF02931.23 AIC16417.1 - 0.058 12.8 0.2 0.32 10.4 0.0 2.1 1 1 0 2 2 2 0 Neurotransmitter-gated ion-channel ligand binding domain COX2_TM PF02790.15 AIC16417.1 - 0.66 10.2 6.1 7.4 6.8 0.3 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain HTH_38 PF13936.6 AIC16419.1 - 0.00097 18.8 0.1 0.0036 17.0 0.1 2.0 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_24 PF13412.6 AIC16419.1 - 0.09 12.3 0.0 0.2 11.2 0.0 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF3849 PF12960.7 AIC16420.1 - 0.19 11.7 0.0 0.19 11.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) DDE_Tnp_IS1595 PF12762.7 AIC16421.1 - 5.8e-19 68.6 0.0 8.6e-19 68.0 0.0 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Cpn60_TCP1 PF00118.24 AIC16423.1 - 2e-176 587.5 19.0 2.3e-176 587.2 19.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family MobB PF03205.14 AIC16423.1 - 0.018 14.9 0.1 0.12 12.2 0.0 2.4 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B HTH_20 PF12840.7 AIC16424.1 - 4.6e-15 55.4 0.7 2.9e-14 52.9 0.0 2.3 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_5 PF01022.20 AIC16424.1 - 7.1e-14 51.4 0.3 6.9e-12 45.0 0.0 2.6 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 AIC16424.1 - 1e-08 34.6 0.2 1e-05 25.0 0.2 3.2 2 1 0 2 2 2 1 Winged helix-turn-helix DNA-binding TrmB PF01978.19 AIC16424.1 - 1.1e-06 28.4 3.8 0.00088 19.1 0.0 3.3 2 1 1 4 4 4 2 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 AIC16424.1 - 1.4e-06 28.2 1.0 5.8e-05 23.0 0.1 3.1 2 1 0 2 2 2 1 Transcriptional regulator PadR-like family DprA_WH PF17782.1 AIC16424.1 - 7e-06 26.1 0.1 1.9e-05 24.7 0.1 1.7 1 0 0 1 1 1 1 DprA winged helix domain HTH_11 PF08279.12 AIC16424.1 - 8.7e-06 25.6 0.1 0.00031 20.6 0.1 2.8 2 0 0 2 2 2 1 HTH domain MarR_2 PF12802.7 AIC16424.1 - 1.6e-05 24.7 0.0 6.3e-05 22.8 0.1 1.9 2 0 0 2 2 2 1 MarR family ArsR PF09824.9 AIC16424.1 - 0.00039 20.0 1.0 0.0043 16.7 0.1 2.4 1 1 1 2 2 2 1 ArsR transcriptional regulator MarR PF01047.22 AIC16424.1 - 0.00043 20.1 0.1 0.0018 18.2 0.0 2.0 2 0 0 2 2 2 1 MarR family DUF1495 PF07381.11 AIC16424.1 - 0.0012 18.6 0.2 0.17 11.7 0.0 2.9 2 1 0 2 2 2 1 Winged helix DNA-binding domain (DUF1495) HxlR PF01638.17 AIC16424.1 - 0.0017 18.2 0.3 0.0077 16.1 0.0 2.2 2 1 1 3 3 3 1 HxlR-like helix-turn-helix HTH_12 PF08461.10 AIC16424.1 - 0.0028 17.6 0.7 0.0094 15.9 0.0 2.3 3 1 0 3 3 3 1 Ribonuclease R winged-helix domain DUF1759 PF03564.15 AIC16424.1 - 0.0035 17.3 1.7 0.0057 16.6 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1759) Rrf2 PF02082.20 AIC16424.1 - 0.0038 17.5 0.9 0.11 12.8 0.0 2.6 3 0 0 3 3 2 1 Transcriptional regulator SMC_ScpB PF04079.16 AIC16424.1 - 0.0076 15.9 1.5 6.5 6.4 0.1 3.2 2 1 2 4 4 4 1 Segregation and condensation complex subunit ScpB SKA2 PF16740.5 AIC16424.1 - 0.014 15.2 1.1 0.093 12.5 0.2 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 HTH_IclR PF09339.10 AIC16424.1 - 0.018 14.8 0.0 0.047 13.5 0.0 1.7 1 0 0 1 1 1 0 IclR helix-turn-helix domain HTH_AsnC-type PF13404.6 AIC16424.1 - 0.031 14.1 0.2 0.9 9.4 0.3 2.8 2 1 0 2 2 2 0 AsnC-type helix-turn-helix domain DUF2250 PF10007.9 AIC16424.1 - 0.058 13.5 0.2 0.058 13.5 0.2 2.6 2 2 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) HTH_Crp_2 PF13545.6 AIC16424.1 - 0.062 13.3 0.3 0.21 11.6 0.0 2.1 2 0 0 2 2 1 0 Crp-like helix-turn-helix domain RuvB_C PF05491.13 AIC16424.1 - 0.086 12.7 0.1 0.33 10.8 0.0 2.0 2 0 0 2 2 2 0 RuvB C-terminal winged helix domain LexA_DNA_bind PF01726.16 AIC16424.1 - 0.13 12.1 0.0 0.5 10.2 0.0 2.0 2 0 0 2 2 2 0 LexA DNA binding domain CorA PF01544.18 AIC16424.1 - 0.14 11.4 3.0 0.73 9.1 3.0 2.0 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein BLOC1_2 PF10046.9 AIC16424.1 - 0.28 11.5 4.5 0.2 12.0 1.1 2.2 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HSP20 PF00011.21 AIC16425.1 - 1.5e-08 34.7 1.8 4.2e-07 30.0 1.8 2.3 1 1 0 1 1 1 1 Hsp20/alpha crystallin family PIH1_CS PF18201.1 AIC16425.1 - 2.5e-07 31.0 0.1 4e-07 30.4 0.1 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain ArsA_HSP20 PF17886.1 AIC16425.1 - 5.1e-06 26.0 0.0 8.4e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA CS PF04969.16 AIC16425.1 - 0.0086 17.1 1.2 0.048 14.7 0.2 2.1 1 1 1 2 2 2 1 CS domain GvpH PF05455.11 AIC16425.1 - 0.015 15.4 0.0 0.019 15.0 0.0 1.3 1 0 0 1 1 1 0 GvpH DUF1735 PF08522.10 AIC16425.1 - 0.089 13.4 0.8 0.3 11.7 0.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1735) Glyco_hydro_65C PF03633.15 AIC16425.1 - 0.11 12.5 0.1 0.27 11.2 0.1 1.7 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, C-terminal domain AAA PF00004.29 AIC16426.1 - 1e-99 330.1 0.0 4.4e-49 166.3 0.0 2.4 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 AIC16426.1 - 1.3e-29 101.7 0.8 7.3e-14 51.3 0.3 2.7 2 0 0 2 2 2 2 AAA+ lid domain CDC48_N PF02359.18 AIC16426.1 - 4.1e-24 84.6 0.0 1.1e-23 83.1 0.0 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_2 PF07724.14 AIC16426.1 - 4e-17 62.9 0.0 2.5e-08 34.3 0.0 2.6 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AIC16426.1 - 6.3e-15 55.3 0.0 1.9e-08 34.2 0.0 2.8 3 0 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIC16426.1 - 6.9e-14 52.6 0.2 3e-05 24.5 0.0 4.0 2 2 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 AIC16426.1 - 3.5e-12 46.8 0.4 0.0044 17.3 0.0 3.9 2 2 1 3 3 3 2 AAA domain TIP49 PF06068.13 AIC16426.1 - 3.3e-11 43.0 0.1 0.00053 19.3 0.0 3.3 3 0 0 3 3 3 2 TIP49 P-loop domain AAA_5 PF07728.14 AIC16426.1 - 8e-11 42.1 0.4 0.00092 19.2 0.1 3.9 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) CDC48_2 PF02933.17 AIC16426.1 - 4.2e-10 39.3 0.0 9.2e-09 35.0 0.0 2.9 3 0 0 3 3 3 1 Cell division protein 48 (CDC48), domain 2 AAA_33 PF13671.6 AIC16426.1 - 6.1e-10 39.4 0.0 0.00036 20.7 0.0 2.8 2 1 0 2 2 2 2 AAA domain AAA_14 PF13173.6 AIC16426.1 - 1.5e-07 31.5 0.0 0.0014 18.7 0.0 2.6 2 0 0 2 2 2 2 AAA domain IstB_IS21 PF01695.17 AIC16426.1 - 1.9e-07 31.0 0.1 0.012 15.3 0.0 2.4 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_18 PF13238.6 AIC16426.1 - 1.9e-07 31.7 0.1 0.017 15.6 0.0 2.9 3 0 0 3 3 2 2 AAA domain Mg_chelatase PF01078.21 AIC16426.1 - 3.2e-07 30.0 0.8 0.013 14.9 0.1 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 AIC16426.1 - 2.7e-06 27.7 0.0 0.052 13.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain RNA_helicase PF00910.22 AIC16426.1 - 3.1e-06 27.5 0.0 0.11 12.9 0.0 2.7 2 0 0 2 2 2 2 RNA helicase AAA_25 PF13481.6 AIC16426.1 - 5.1e-06 26.2 4.6 0.5 9.9 0.6 4.1 3 1 0 3 3 3 1 AAA domain Sigma54_activat PF00158.26 AIC16426.1 - 5.1e-06 26.3 0.0 0.16 11.6 0.0 3.1 2 1 0 2 2 2 2 Sigma-54 interaction domain Zeta_toxin PF06414.12 AIC16426.1 - 5.7e-06 25.7 0.2 0.11 11.7 0.1 2.4 2 0 0 2 2 2 2 Zeta toxin AAA_7 PF12775.7 AIC16426.1 - 6.1e-06 25.9 0.0 0.11 12.0 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_3 PF07726.11 AIC16426.1 - 6.7e-06 26.0 0.0 0.15 11.9 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 AIC16426.1 - 9.2e-06 25.7 0.0 0.25 11.3 0.0 2.6 2 1 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 AIC16426.1 - 1.5e-05 24.9 0.0 0.18 11.5 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_30 PF13604.6 AIC16426.1 - 3e-05 23.8 0.4 0.14 11.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_24 PF13479.6 AIC16426.1 - 5.6e-05 23.0 0.0 0.33 10.7 0.0 2.5 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AIC16426.1 - 6.2e-05 23.0 0.2 0.67 9.9 0.0 3.2 4 0 0 4 4 3 2 NACHT domain DUF2075 PF09848.9 AIC16426.1 - 0.00011 21.6 0.0 0.11 11.7 0.0 2.5 2 0 0 2 2 2 2 Uncharacterized conserved protein (DUF2075) CPT PF07931.12 AIC16426.1 - 0.00013 21.9 0.2 0.65 9.8 0.0 3.3 3 1 0 3 3 3 2 Chloramphenicol phosphotransferase-like protein PhoH PF02562.16 AIC16426.1 - 0.00016 21.2 0.2 0.62 9.5 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein ATPase PF06745.13 AIC16426.1 - 0.00016 21.1 0.2 0.37 10.1 0.0 3.1 3 0 0 3 3 3 1 KaiC Bac_DnaA PF00308.18 AIC16426.1 - 0.00019 21.4 0.0 0.11 12.3 0.0 3.5 3 1 1 4 4 3 1 Bacterial dnaA protein NB-ARC PF00931.22 AIC16426.1 - 0.00019 20.7 0.1 0.47 9.6 0.0 2.9 3 0 0 3 3 3 2 NB-ARC domain ResIII PF04851.15 AIC16426.1 - 0.0004 20.4 0.1 0.54 10.2 0.0 2.6 3 0 0 3 3 2 1 Type III restriction enzyme, res subunit Parvo_NS1 PF01057.17 AIC16426.1 - 0.00042 19.5 0.2 0.43 9.6 0.0 2.2 2 0 0 2 2 2 2 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 AIC16426.1 - 0.00054 20.3 1.4 0.7 10.2 0.1 2.8 2 1 1 3 3 2 1 AAA domain Hydin_ADK PF17213.3 AIC16426.1 - 0.00058 20.2 0.2 0.59 10.4 0.0 2.3 2 0 0 2 2 2 1 Hydin Adenylate kinase-like domain AAA_17 PF13207.6 AIC16426.1 - 0.00066 20.1 0.1 1.3 9.5 0.0 3.3 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 AIC16426.1 - 0.00069 20.1 0.0 2.4 8.7 0.0 2.7 2 0 0 2 2 2 2 ABC transporter DUF815 PF05673.13 AIC16426.1 - 0.00081 18.6 0.0 0.93 8.6 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AFG1_ATPase PF03969.16 AIC16426.1 - 0.0011 18.0 0.0 0.21 10.4 0.0 2.2 2 0 0 2 2 2 1 AFG1-like ATPase Viral_helicase1 PF01443.18 AIC16426.1 - 0.0015 18.3 0.0 0.33 10.6 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase T2SSE PF00437.20 AIC16426.1 - 0.0016 17.5 0.0 1.9 7.5 0.0 2.6 2 0 0 2 2 2 2 Type II/IV secretion system protein NTPase_1 PF03266.15 AIC16426.1 - 0.0019 18.1 4.8 2 8.3 0.0 4.1 4 1 1 5 5 3 1 NTPase Cytidylate_kin PF02224.18 AIC16426.1 - 0.0019 17.9 0.2 2.2 8.0 0.0 2.5 2 0 0 2 2 2 2 Cytidylate kinase Vps4_C PF09336.10 AIC16426.1 - 0.002 18.1 0.4 0.22 11.5 0.1 2.9 3 0 0 3 3 2 1 Vps4 C terminal oligomerisation domain Torsin PF06309.11 AIC16426.1 - 0.0021 18.1 0.0 3 8.0 0.0 2.5 2 0 0 2 2 2 1 Torsin TniB PF05621.11 AIC16426.1 - 0.0022 17.5 0.0 0.57 9.6 0.0 2.8 3 0 0 3 3 3 1 Bacterial TniB protein ATPase_2 PF01637.18 AIC16426.1 - 0.018 15.0 0.0 0.47 10.3 0.0 2.7 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea Rad17 PF03215.15 AIC16426.1 - 0.021 14.7 0.1 24 4.8 0.0 3.4 2 1 1 3 3 3 0 Rad17 P-loop domain Cytidylate_kin2 PF13189.6 AIC16426.1 - 0.021 14.9 0.0 3.4 7.8 0.0 2.5 2 0 0 2 2 2 0 Cytidylate kinase-like family Sigma54_activ_2 PF14532.6 AIC16426.1 - 0.025 14.7 0.0 13 5.9 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain MCM PF00493.23 AIC16426.1 - 0.026 13.6 0.0 4.1 6.4 0.0 2.6 3 0 0 3 3 2 0 MCM P-loop domain SKI PF01202.22 AIC16426.1 - 0.03 14.5 0.2 19 5.4 0.0 3.1 3 0 0 3 3 3 0 Shikimate kinase AAA_29 PF13555.6 AIC16426.1 - 0.032 14.0 0.1 8.5 6.2 0.0 2.9 3 0 0 3 3 2 0 P-loop containing region of AAA domain Zot PF05707.12 AIC16426.1 - 0.068 12.8 0.0 1.4 8.5 0.0 2.5 2 1 0 2 2 2 0 Zonular occludens toxin (Zot) Guanylate_kin PF00625.21 AIC16426.1 - 0.083 12.6 0.7 16 5.1 0.0 3.6 3 2 1 4 4 3 0 Guanylate kinase MannoseP_isomer PF01050.18 AIC16427.1 - 6e-25 87.9 0.0 6.6e-25 87.8 0.0 1.0 1 0 0 1 1 1 1 Mannose-6-phosphate isomerase Cupin_2 PF07883.11 AIC16427.1 - 7.1e-10 38.5 0.0 9.9e-10 38.0 0.0 1.3 1 0 0 1 1 1 1 Cupin domain Lyx_isomer PF07385.12 AIC16427.1 - 0.0024 17.2 0.0 0.0032 16.7 0.0 1.4 1 1 0 1 1 1 1 D-lyxose isomerase AraC_binding PF02311.19 AIC16427.1 - 0.0053 16.7 0.0 0.0094 15.9 0.0 1.4 1 1 0 1 1 1 1 AraC-like ligand binding domain Pirin_C_2 PF17954.1 AIC16427.1 - 0.029 14.5 0.0 0.035 14.3 0.0 1.2 1 0 0 1 1 1 0 Quercetinase C-terminal cupin domain DUF4384 PF14326.6 AIC16427.1 - 0.029 14.5 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4384) FdtA PF05523.11 AIC16427.1 - 0.036 13.8 0.0 0.051 13.3 0.0 1.3 1 1 0 1 1 1 0 WxcM-like, C-terminal Cupin_1 PF00190.22 AIC16427.1 - 0.15 11.7 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Cupin CENP-C_C PF11699.8 AIC16427.1 - 0.16 12.2 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 Mif2/CENP-C like Epimerase PF01370.21 AIC16428.1 - 1.1e-56 192.1 0.2 1.3e-56 191.8 0.2 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 AIC16428.1 - 6.6e-53 180.2 0.1 1.1e-52 179.5 0.1 1.4 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 AIC16428.1 - 2.6e-27 95.5 0.9 3.6e-27 95.1 0.9 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 AIC16428.1 - 1.5e-22 80.0 0.1 2e-22 79.6 0.1 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 AIC16428.1 - 1.2e-20 73.9 5.0 2.5e-19 69.6 5.0 2.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 AIC16428.1 - 1.4e-12 47.4 0.3 7.2e-08 31.9 0.1 2.4 2 1 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 AIC16428.1 - 4.5e-10 39.7 0.5 3.2e-09 36.9 0.2 2.0 2 0 0 2 2 2 1 NAD(P)H-binding adh_short PF00106.25 AIC16428.1 - 0.00024 20.6 4.1 0.00055 19.5 4.1 1.6 1 1 0 1 1 1 1 short chain dehydrogenase NmrA PF05368.13 AIC16428.1 - 0.00066 19.3 3.5 0.0056 16.3 3.2 2.2 2 0 0 2 2 2 1 NmrA-like family Ldh_1_N PF00056.23 AIC16428.1 - 0.0025 17.9 0.2 0.004 17.2 0.2 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain KR PF08659.10 AIC16428.1 - 0.042 13.8 2.3 1.2 9.0 2.3 2.5 1 1 0 1 1 1 0 KR domain Mannosyl_trans4 PF15971.5 AIC16429.1 - 0.012 15.5 2.1 0.012 15.5 2.1 3.3 2 1 0 2 2 2 0 DolP-mannose mannosyltransferase APS_kinase PF01583.20 AIC16430.1 - 3.7e-55 186.1 0.0 4.4e-55 185.9 0.0 1.0 1 0 0 1 1 1 1 Adenylylsulphate kinase AAA_33 PF13671.6 AIC16430.1 - 1.2e-07 32.0 0.0 2.7e-07 30.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIC16430.1 - 1.8e-07 31.7 0.0 2.9e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain KTI12 PF08433.10 AIC16430.1 - 6.5e-06 25.8 0.0 8e-06 25.5 0.0 1.1 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_17 PF13207.6 AIC16430.1 - 0.0002 21.8 0.1 0.00087 19.7 0.0 2.0 2 1 1 3 3 2 1 AAA domain NTPase_1 PF03266.15 AIC16430.1 - 0.0015 18.5 0.0 0.0022 17.9 0.0 1.3 1 0 0 1 1 1 1 NTPase NB-ARC PF00931.22 AIC16430.1 - 0.0022 17.2 0.0 0.0035 16.6 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain cobW PF02492.19 AIC16430.1 - 0.0029 17.2 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain 6PF2K PF01591.18 AIC16430.1 - 0.0033 16.7 0.0 0.0045 16.3 0.0 1.2 1 0 0 1 1 1 1 6-phosphofructo-2-kinase AAA_22 PF13401.6 AIC16430.1 - 0.0089 16.3 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 AIC16430.1 - 0.012 15.5 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 NACHT domain MeaB PF03308.16 AIC16430.1 - 0.018 14.0 0.0 0.039 12.9 0.0 1.5 1 1 1 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ParA PF10609.9 AIC16430.1 - 0.021 14.3 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 NUBPL iron-transfer P-loop NTPase dNK PF01712.19 AIC16430.1 - 0.022 14.6 0.1 2.2 8.1 0.1 2.3 1 1 0 2 2 2 0 Deoxynucleoside kinase DUF2075 PF09848.9 AIC16430.1 - 0.026 13.8 0.0 0.032 13.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) KAP_NTPase PF07693.14 AIC16430.1 - 0.036 13.3 0.0 0.036 13.3 0.0 1.2 1 0 0 1 1 1 0 KAP family P-loop domain AAA_16 PF13191.6 AIC16430.1 - 0.04 14.3 0.0 0.05 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 AIC16430.1 - 0.047 12.7 0.0 0.078 12.0 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_30 PF13604.6 AIC16430.1 - 0.061 13.0 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 AIC16430.1 - 0.078 13.0 0.0 0.082 13.0 0.0 1.2 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain SRP54 PF00448.22 AIC16430.1 - 0.079 12.6 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 AIC16430.1 - 0.1 13.0 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 RNA helicase CLP1_P PF16575.5 AIC16430.1 - 0.12 12.2 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_5 PF07728.14 AIC16430.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Thymidylate_kin PF02223.17 AIC16430.1 - 0.14 11.8 0.1 0.35 10.5 0.0 1.7 2 0 0 2 2 2 0 Thymidylate kinase AAA_7 PF12775.7 AIC16430.1 - 0.16 11.5 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Viral_helicase1 PF01443.18 AIC16430.1 - 0.16 11.6 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Glyco_transf_4 PF13439.6 AIC16431.1 - 9.7e-20 71.2 0.0 1.8e-19 70.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_1_4 PF13692.6 AIC16431.1 - 1e-15 58.3 0.0 2.1e-15 57.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glycos_transf_1 PF00534.20 AIC16431.1 - 2.7e-14 53.0 0.0 4.6e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_4 PF13579.6 AIC16431.1 - 1e-13 52.0 0.0 2.2e-13 50.9 0.0 1.5 1 1 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_1_2 PF13524.6 AIC16431.1 - 8.1e-10 39.0 0.0 2e-09 37.7 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_4_2 PF13477.6 AIC16431.1 - 0.002 18.1 0.1 0.021 14.9 0.1 2.3 1 1 0 1 1 1 1 Glycosyl transferase 4-like Glyco_transf_5 PF08323.11 AIC16431.1 - 0.0083 15.8 0.0 0.02 14.6 0.0 1.6 1 1 0 1 1 1 1 Starch synthase catalytic domain Sulfotransfer_3 PF13469.6 AIC16432.1 - 9.1e-16 58.9 0.0 3.3e-08 34.2 0.0 2.3 1 1 1 2 2 2 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 AIC16432.1 - 8.5e-13 48.4 0.1 1.3e-12 47.8 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_2 PF03567.14 AIC16432.1 - 0.14 12.0 0.0 2.6 7.9 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase family CAP59_mtransfer PF11735.8 AIC16432.1 - 0.16 11.6 0.0 0.23 11.1 0.0 1.2 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 PMT_2 PF13231.6 AIC16433.1 - 0.00012 22.3 13.8 0.00012 22.3 13.8 5.1 4 1 0 4 4 4 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Acetyltransf_9 PF13527.7 AIC16434.1 - 5.6e-11 42.6 0.0 9.7e-11 41.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain DUF3473 PF11959.8 AIC16435.1 - 1.8e-32 112.1 0.0 2.7e-32 111.5 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3473) Polysacc_deac_1 PF01522.21 AIC16435.1 - 7.8e-06 25.8 0.0 1.3e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF2334 PF10096.9 AIC16435.1 - 0.072 12.7 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Polysacc_synt_3 PF13440.6 AIC16436.1 - 0.00031 20.1 17.0 0.00031 20.1 17.0 2.8 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein DUF2427 PF10348.9 AIC16436.1 - 0.037 13.8 1.3 0.037 13.8 1.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF2427) Polysacc_synt PF01943.17 AIC16436.1 - 0.088 12.2 46.5 0.07 12.5 27.3 3.1 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein Glycos_transf_2 PF00535.26 AIC16437.1 - 2.1e-24 86.2 0.1 2.8e-24 85.8 0.1 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIC16437.1 - 2.8e-10 40.5 0.1 1e-09 38.6 0.1 1.8 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 AIC16437.1 - 0.014 14.9 0.1 0.053 13.0 0.0 1.9 2 0 0 2 2 2 0 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 AIC16437.1 - 0.016 15.7 0.0 0.028 14.9 0.0 1.4 1 0 0 1 1 1 0 Glycosyl transferase family 2 NTP_transf_3 PF12804.7 AIC16437.1 - 0.1 12.9 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 MobA-like NTP transferase domain DUF1129 PF06570.11 AIC16437.1 - 0.16 11.4 5.2 0.47 9.9 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) OppC_N PF12911.7 AIC16437.1 - 1.1 9.2 5.1 0.43 10.6 1.7 2.0 1 1 1 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Exo_endo_phos PF03372.23 AIC16442.1 - 4.7e-09 36.1 0.3 5.9e-09 35.8 0.3 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family ParBc PF02195.18 AIC16444.1 - 1.4e-22 79.7 0.0 5.1e-22 78.0 0.0 2.0 2 0 0 2 2 2 1 ParB-like nuclease domain HTH_ParB PF17762.1 AIC16444.1 - 5.5e-05 22.9 0.7 0.00019 21.2 0.7 2.0 1 0 0 1 1 1 1 HTH domain found in ParB protein KorB PF08535.10 AIC16444.1 - 0.00023 21.1 0.5 0.00073 19.5 0.1 2.2 2 1 0 2 2 2 1 KorB domain SHMT PF00464.19 AIC16445.1 - 4.6e-72 242.8 0.1 4.6e-72 242.8 0.1 1.4 2 0 0 2 2 2 1 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 AIC16445.1 - 8.4e-06 25.3 0.0 1.9e-05 24.1 0.0 1.7 1 1 0 1 1 1 1 Beta-eliminating lyase Aminotran_1_2 PF00155.21 AIC16445.1 - 3.6e-05 23.1 0.0 0.0001 21.6 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 AIC16445.1 - 0.0013 17.7 0.3 0.0038 16.2 0.3 1.8 1 1 0 1 1 1 1 Aminotransferase class-V SelA PF03841.13 AIC16445.1 - 0.0014 17.7 0.0 0.0028 16.7 0.0 1.4 1 0 0 1 1 1 1 L-seryl-tRNA selenium transferase TssO PF17561.2 AIC16445.1 - 0.092 12.9 0.8 0.35 11.0 0.2 2.0 2 0 0 2 2 2 0 Type VI secretion system, TssO Hist_deacetyl PF00850.19 AIC16446.1 - 4e-67 226.9 0.0 5e-67 226.5 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain Lum_binding PF00677.17 AIC16447.1 - 7e-46 154.1 3.5 2.4e-24 85.1 0.2 2.0 2 0 0 2 2 2 2 Lumazine binding domain MazE_antitoxin PF04014.18 AIC16447.1 - 0.016 15.1 0.2 12 6.0 0.0 3.2 3 0 0 3 3 3 0 Antidote-toxin recognition MazE, bacterial antitoxin ATP-synt_ab_Xtn PF16886.5 AIC16447.1 - 0.034 14.0 0.1 0.065 13.1 0.1 1.6 1 1 0 1 1 1 0 ATPsynthase alpha/beta subunit N-term extension SH3_15 PF18346.1 AIC16447.1 - 0.054 13.8 0.8 1.4 9.3 0.0 3.0 2 1 1 3 3 3 0 Mind bomb SH3 repeat domain YabP PF07873.11 AIC16447.1 - 0.064 13.1 0.0 9.2 6.1 0.0 2.5 2 0 0 2 2 2 0 YabP family DHBP_synthase PF00926.19 AIC16448.1 - 6.2e-59 198.8 1.0 7.2e-59 198.6 1.0 1.0 1 0 0 1 1 1 1 3,4-dihydroxy-2-butanone 4-phosphate synthase DMRL_synthase PF00885.19 AIC16449.1 - 4.3e-36 123.8 0.4 4.8e-36 123.7 0.4 1.0 1 0 0 1 1 1 1 6,7-dimethyl-8-ribityllumazine synthase Metallophos_3 PF14582.6 AIC16449.1 - 0.082 12.2 0.3 0.21 10.8 0.3 1.7 1 1 1 2 2 2 0 Metallophosphoesterase, calcineurin superfamily GCH_III PF05165.12 AIC16450.1 - 5.9e-57 192.8 1.1 6.5e-57 192.6 1.1 1.0 1 0 0 1 1 1 1 GTP cyclohydrolase III Guanylate_cyc PF00211.20 AIC16450.1 - 0.00091 18.9 0.2 0.0029 17.2 0.0 1.8 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Amidohydro_1 PF01979.20 AIC16451.1 - 3.4e-46 158.1 3.0 4e-46 157.9 3.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 AIC16451.1 - 1.9e-14 54.1 5.8 3.6e-11 43.2 1.6 3.0 1 1 1 2 2 2 2 Amidohydrolase family DUF3420 PF11900.8 AIC16451.1 - 0.051 13.7 0.1 0.1 12.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3420) RibD_C PF01872.17 AIC16452.1 - 2.2e-48 164.8 1.8 2.5e-48 164.6 1.8 1.0 1 0 0 1 1 1 1 RibD C-terminal domain His_biosynth PF00977.21 AIC16452.1 - 0.056 12.9 0.7 5.7 6.3 0.1 2.1 1 1 1 2 2 2 0 Histidine biosynthesis protein DUF87 PF01935.17 AIC16453.1 - 9.6e-15 55.3 8.1 4.7e-14 53.0 0.2 3.4 2 1 0 2 2 2 1 Helicase HerA, central domain DUF853 PF05872.12 AIC16453.1 - 1.2e-08 34.0 10.3 3.5e-08 32.5 0.0 3.3 3 0 0 3 3 3 2 Bacterial protein of unknown function (DUF853) AAA_10 PF12846.7 AIC16453.1 - 2.1e-05 23.6 3.2 0.00021 20.4 0.0 3.1 3 0 0 3 3 3 1 AAA-like domain FtsK_SpoIIIE PF01580.18 AIC16453.1 - 0.00039 19.8 2.3 0.00046 19.6 0.1 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family TrwB_AAD_bind PF10412.9 AIC16453.1 - 0.0023 16.9 0.4 0.0059 15.6 0.0 1.9 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain AAA_18 PF13238.6 AIC16453.1 - 0.032 14.8 0.0 0.28 11.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain DotD PF16816.5 AIC16453.1 - 0.07 13.1 0.1 0.2 11.6 0.1 1.7 1 0 0 1 1 1 0 DotD protein AAA_22 PF13401.6 AIC16453.1 - 0.13 12.5 0.0 0.68 10.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 AIC16453.1 - 0.2 11.4 1.6 1.6 8.4 0.0 2.7 2 1 1 3 3 3 0 Sigma-54 interaction domain ABC_tran PF00005.27 AIC16453.1 - 0.22 12.0 3.2 0.58 10.7 0.0 2.8 2 1 0 2 2 2 0 ABC transporter ResIII PF04851.15 AIC16453.1 - 0.41 10.6 5.7 0.69 9.9 0.0 2.9 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit DUF755 PF05501.11 AIC16453.1 - 4.6 7.5 10.1 9.5 6.5 10.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) Snapin_Pallidin PF14712.6 AIC16453.1 - 9.4 6.7 15.3 5.5 7.5 11.2 2.5 1 1 1 2 2 2 0 Snapin/Pallidin Pilin_N PF07790.11 AIC16454.1 - 0.064 14.2 0.4 0.091 13.7 0.4 1.3 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF3328 PF11807.8 AIC16454.1 - 0.08 12.7 0.2 0.087 12.6 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) DUF2070 PF09843.9 AIC16454.1 - 0.18 10.1 0.8 0.17 10.1 0.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HTH_45 PF14947.6 AIC16455.1 - 1.7e-08 34.3 0.1 2.2e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIC16455.1 - 0.00093 19.1 0.0 0.0014 18.5 0.0 1.2 1 0 0 1 1 1 1 MarR family PadR PF03551.14 AIC16455.1 - 0.011 15.6 0.0 0.019 14.9 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family TrmB PF01978.19 AIC16455.1 - 0.028 14.3 0.0 0.038 13.9 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIC16455.1 - 0.03 14.8 0.0 0.047 14.2 0.0 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain HTH_34 PF13601.6 AIC16455.1 - 0.034 14.3 0.0 0.048 13.8 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain Peroxin-13_N PF04088.13 AIC16456.1 - 0.0012 19.2 0.1 0.0038 17.5 0.0 1.7 1 1 1 2 2 2 1 Peroxin 13, N-terminal region LapA_dom PF06305.11 AIC16456.1 - 0.0068 16.2 0.1 0.0068 16.2 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide assembly protein A domain DUF2207 PF09972.9 AIC16456.1 - 0.029 13.1 0.0 0.034 12.9 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM240 PF15207.6 AIC16456.1 - 0.1 12.3 0.2 0.17 11.6 0.0 1.4 2 0 0 2 2 2 0 TMEM240 family Cupredoxin_1 PF13473.6 AIC16457.1 - 5.8e-08 32.8 0.1 7.8e-08 32.4 0.1 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIC16457.1 - 0.0047 17.3 0.5 0.0096 16.4 0.4 1.5 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Aldedh PF00171.22 AIC16458.1 - 8.2e-153 509.2 0.1 1.1e-152 508.8 0.1 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Rad50_zn_hook PF04423.14 AIC16458.1 - 0.13 12.2 0.1 0.4 10.6 0.1 1.9 1 0 0 1 1 1 0 Rad50 zinc hook motif Pro_dh PF01619.18 AIC16459.1 - 9.7e-28 97.5 0.0 1.8e-27 96.6 0.0 1.4 1 1 0 1 1 1 1 Proline dehydrogenase TusA PF01206.17 AIC16459.1 - 0.17 11.7 0.0 0.46 10.3 0.0 1.7 1 0 0 1 1 1 0 Sulfurtransferase TusA MarR PF01047.22 AIC16460.1 - 1.7e-14 53.4 0.0 3.6e-14 52.4 0.0 1.6 2 0 0 2 2 2 1 MarR family MarR_2 PF12802.7 AIC16460.1 - 6.9e-12 45.1 0.0 1.1e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 AIC16460.1 - 1.2e-05 24.7 0.0 5.2e-05 22.7 0.0 2.2 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding HTH_27 PF13463.6 AIC16460.1 - 1.9e-05 25.1 0.0 3.6e-05 24.2 0.0 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain HTH_IclR PF09339.10 AIC16460.1 - 0.001 18.8 0.0 0.0023 17.7 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_34 PF13601.6 AIC16460.1 - 0.015 15.5 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_Crp_2 PF13545.6 AIC16460.1 - 0.061 13.3 0.6 0.35 10.9 0.0 2.5 3 1 1 4 4 4 0 Crp-like helix-turn-helix domain DUF501 PF04417.12 AIC16460.1 - 0.12 12.2 0.1 6.4 6.6 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF501) DNA_binding_1 PF01035.20 AIC16462.1 - 6.6e-32 109.5 2.3 5.3e-31 106.6 0.3 2.6 2 1 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, DNA binding domain Ada_Zn_binding PF02805.16 AIC16462.1 - 2.8e-29 100.9 7.2 5.1e-29 100.1 6.0 2.0 2 0 0 2 2 2 1 Metal binding domain of Ada HTH_18 PF12833.7 AIC16462.1 - 2.8e-18 65.9 1.0 1.6e-17 63.5 0.7 2.2 2 0 0 2 2 2 1 Helix-turn-helix domain HTH_AraC PF00165.23 AIC16462.1 - 5.4e-14 51.9 0.0 2.6e-09 37.0 0.0 3.0 3 0 0 3 3 3 2 Bacterial regulatory helix-turn-helix proteins, AraC family Methyltransf_1N PF02870.15 AIC16462.1 - 0.0057 17.4 0.0 0.015 16.1 0.0 1.7 2 0 0 2 2 2 1 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain Inositol_P PF00459.25 AIC16463.1 - 4.2e-30 105.2 0.1 4.9e-30 105.0 0.1 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 AIC16463.1 - 4.6e-07 29.5 0.0 7.1e-07 28.9 0.0 1.3 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain PDZ_2 PF13180.6 AIC16465.1 - 0.0082 16.5 0.0 0.083 13.2 0.0 2.5 2 1 0 2 2 2 1 PDZ domain DUF790 PF05626.11 AIC16468.1 - 1.2e-91 307.3 0.0 1.8e-76 257.4 0.0 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF790) ResIII PF04851.15 AIC16469.1 - 1.2e-24 87.3 0.0 3.1e-24 85.9 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit XPB_DRD PF18458.1 AIC16469.1 - 5.2e-19 67.9 0.3 1.3e-18 66.6 0.3 1.7 1 0 0 1 1 1 1 Xeroderma pigmentosum group B helicase damage recognition domain ERCC3_RAD25_C PF16203.5 AIC16469.1 - 2.2e-17 63.1 0.1 7.7e-17 61.3 0.1 1.7 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C PF00271.31 AIC16469.1 - 1.1e-15 58.0 0.0 3.7e-15 56.2 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 AIC16469.1 - 2.3e-10 40.5 0.0 4.8e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C_2 PF13307.6 AIC16469.1 - 0.027 14.7 0.2 0.14 12.3 0.0 2.3 1 1 1 2 2 2 0 Helicase C-terminal domain Ammonium_transp PF00909.21 AIC16471.1 - 4.6e-116 387.8 34.5 5.5e-116 387.5 34.5 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family DUF4307 PF14155.6 AIC16471.1 - 4.6 7.1 8.2 23 4.9 1.6 3.8 2 2 1 3 3 3 0 Domain of unknown function (DUF4307) PepSY PF03413.19 AIC16474.1 - 3.3e-05 24.3 0.1 7.7e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain HTH_45 PF14947.6 AIC16475.1 - 6.8e-09 35.6 0.4 8.2e-09 35.3 0.4 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix PadR PF03551.14 AIC16475.1 - 0.00066 19.6 0.0 0.0012 18.8 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 AIC16475.1 - 0.0084 16.3 0.1 0.012 15.8 0.1 1.4 1 1 0 1 1 1 1 Winged helix DNA-binding domain MarR PF01047.22 AIC16475.1 - 0.0092 15.9 0.0 0.014 15.3 0.0 1.3 1 0 0 1 1 1 1 MarR family DUF4364 PF14277.6 AIC16475.1 - 0.011 15.4 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) HTH_27 PF13463.6 AIC16475.1 - 0.036 14.6 0.0 0.055 14.0 0.0 1.4 1 1 0 1 1 1 0 Winged helix DNA-binding domain DUF3051 PF11252.8 AIC16475.1 - 0.091 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3051) TrmB PF01978.19 AIC16475.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF4231 PF14015.6 AIC16476.1 - 0.16 12.4 0.5 3.7 8.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF45 PF01863.17 AIC16477.1 - 1.1e-53 182.4 1.3 1.3e-53 182.2 1.3 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.10 AIC16477.1 - 0.00096 19.3 1.4 0.002 18.2 1.4 1.4 1 0 0 1 1 1 1 WLM domain Clr5 PF14420.6 AIC16477.1 - 0.0093 16.2 0.2 2.7 8.3 0.0 2.8 2 0 0 2 2 2 2 Clr5 domain SprT-like PF10263.9 AIC16477.1 - 0.02 14.7 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 SprT-like family Peptidase_M56 PF05569.11 AIC16477.1 - 0.086 12.0 1.1 0.18 10.9 1.1 1.5 1 0 0 1 1 1 0 BlaR1 peptidase M56 SWI2_SNF2 PF18766.1 AIC16478.1 - 4e-75 252.3 0.1 8.8e-75 251.2 0.1 1.6 1 0 0 1 1 1 1 SWI2/SNF2 ATPase HSDR_N PF04313.14 AIC16478.1 - 7.2e-31 107.7 1.0 4.2e-30 105.2 0.2 2.6 2 0 0 2 2 2 1 Type I restriction enzyme R protein N terminus (HSDR_N) ResIII PF04851.15 AIC16478.1 - 3e-19 69.6 0.5 3e-19 69.6 0.5 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DUF3387 PF11867.8 AIC16478.1 - 4e-14 52.7 10.9 8e-14 51.8 10.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3387) DUF1160 PF06648.11 AIC16478.1 - 0.0067 16.4 0.7 0.23 11.5 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1160) DUF2075 PF09848.9 AIC16478.1 - 0.016 14.5 0.7 0.18 11.0 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) HSDR_N_2 PF13588.6 AIC16478.1 - 0.017 15.1 0.0 0.048 13.7 0.0 1.7 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Cdh1_DBD_1 PF18196.1 AIC16478.1 - 0.025 14.9 0.7 0.46 10.8 0.2 3.1 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 SNF2_N PF00176.23 AIC16478.1 - 0.027 13.2 0.0 0.9 8.2 0.0 2.6 2 1 0 2 2 2 0 SNF2 family N-terminal domain AAA_22 PF13401.6 AIC16478.1 - 0.065 13.5 0.1 0.68 10.2 0.0 2.9 3 0 0 3 3 3 0 AAA domain CLP1_P PF16575.5 AIC16478.1 - 0.077 12.8 0.0 28 4.5 0.0 3.4 3 0 0 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop DUF2175 PF09943.9 AIC16478.1 - 0.081 13.2 2.2 17 5.8 0.1 4.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) PEP-utilisers_N PF05524.13 AIC16478.1 - 0.17 12.0 3.7 0.44 10.7 0.2 3.3 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal Methylase_S PF01420.19 AIC16479.1 - 1.9e-31 109.6 1.6 2.9e-15 56.9 0.1 2.3 2 0 0 2 2 2 2 Type I restriction modification DNA specificity domain N6_Mtase PF02384.16 AIC16480.1 - 5.3e-106 354.4 0.1 1.4e-105 353.1 0.0 1.6 2 0 0 2 2 2 1 N-6 DNA Methylase HsdM_N PF12161.8 AIC16480.1 - 5.2e-28 98.4 0.2 5.2e-28 98.4 0.2 2.3 3 0 0 3 3 3 1 HsdM N-terminal domain UPF0020 PF01170.18 AIC16480.1 - 0.00021 21.1 0.0 0.0008 19.1 0.0 2.1 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 AIC16480.1 - 0.14 11.7 0.1 0.49 9.9 0.0 1.9 3 0 0 3 3 3 0 Methyltransferase small domain DUF596 PF04591.12 AIC16481.1 - 0.053 13.7 0.0 0.083 13.0 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function, DUF596 HxlR PF01638.17 AIC16482.1 - 7.4e-27 93.0 1.1 9e-27 92.8 1.1 1.1 1 0 0 1 1 1 1 HxlR-like helix-turn-helix PadR PF03551.14 AIC16482.1 - 0.0039 17.1 0.1 0.0065 16.4 0.1 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family HTH_34 PF13601.6 AIC16482.1 - 0.014 15.5 0.1 0.021 15.0 0.1 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR PF01047.22 AIC16482.1 - 0.03 14.2 0.3 0.063 13.2 0.3 1.5 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 AIC16482.1 - 0.052 13.1 0.1 0.12 12.0 0.1 1.6 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_20 PF12840.7 AIC16482.1 - 0.069 13.2 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Proteasome PF00227.26 AIC16483.1 - 1.2e-40 139.0 0.0 1.4e-40 138.8 0.0 1.0 1 0 0 1 1 1 1 Proteasome subunit Proteasome PF00227.26 AIC16484.1 - 6e-49 166.1 1.0 6.9e-49 165.9 1.0 1.0 1 0 0 1 1 1 1 Proteasome subunit MarR PF01047.22 AIC16486.1 - 1.1e-05 25.3 0.1 2.7e-05 24.0 0.1 1.6 1 0 0 1 1 1 1 MarR family DUF2250 PF10007.9 AIC16486.1 - 1.8e-05 24.7 0.0 0.00033 20.7 0.1 2.3 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2250) MarR_2 PF12802.7 AIC16486.1 - 4.6e-05 23.2 0.0 0.00016 21.5 0.0 1.9 2 0 0 2 2 2 1 MarR family HTH_5 PF01022.20 AIC16486.1 - 0.0031 17.4 0.3 0.0082 16.0 0.3 1.7 2 0 0 2 2 2 1 Bacterial regulatory protein, arsR family Rrf2 PF02082.20 AIC16486.1 - 0.0074 16.6 0.1 0.12 12.7 0.1 2.4 2 0 0 2 2 2 1 Transcriptional regulator HTH_20 PF12840.7 AIC16486.1 - 0.011 15.8 1.1 0.03 14.4 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_24 PF13412.6 AIC16486.1 - 0.024 14.2 0.0 0.056 13.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF4423 PF14394.6 AIC16486.1 - 0.03 14.0 0.0 0.054 13.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4423) TrmB PF01978.19 AIC16486.1 - 0.031 14.2 0.0 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB GntR PF00392.21 AIC16486.1 - 0.035 13.8 0.1 0.11 12.2 0.1 1.8 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family HTH_11 PF08279.12 AIC16486.1 - 0.048 13.6 0.1 0.29 11.1 0.1 2.2 2 0 0 2 2 2 0 HTH domain HTH_27 PF13463.6 AIC16486.1 - 0.049 14.1 0.1 0.26 11.8 0.0 2.2 3 0 0 3 3 2 0 Winged helix DNA-binding domain PaaX PF07848.12 AIC16486.1 - 0.059 13.6 0.1 0.11 12.7 0.1 1.5 1 0 0 1 1 1 0 PaaX-like protein HemN_C PF06969.16 AIC16486.1 - 0.1 12.7 0.1 0.38 10.9 0.1 1.9 1 0 0 1 1 1 0 HemN C-terminal domain zf-met PF12874.7 AIC16487.1 - 0.00072 19.9 1.1 0.00099 19.4 1.1 1.3 1 0 0 1 1 1 1 Zinc-finger of C2H2 type DUF629 PF04780.12 AIC16487.1 - 0.0023 16.6 0.0 0.0023 16.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 AIC16487.1 - 0.0035 17.7 0.3 0.0044 17.4 0.3 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC16487.1 - 0.0048 17.6 0.4 0.0059 17.4 0.4 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIC16487.1 - 0.0089 16.3 0.4 0.015 15.6 0.4 1.4 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 AIC16487.1 - 0.021 14.4 0.0 0.041 13.5 0.0 1.5 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger HicB_lk_antitox PF15919.5 AIC16488.1 - 4.3e-06 26.8 0.0 4.8e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 HicB_like antitoxin of bacterial toxin-antitoxin system DUF1902 PF08972.11 AIC16488.1 - 8.8e-05 22.4 0.0 9.3e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1902) APP_E2 PF12925.7 AIC16488.1 - 0.026 14.2 0.0 0.031 14.0 0.0 1.1 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein HicA_toxin PF07927.12 AIC16489.1 - 2.6e-20 72.2 0.5 3.1e-20 71.9 0.5 1.1 1 0 0 1 1 1 1 HicA toxin of bacterial toxin-antitoxin, HTH_24 PF13412.6 AIC16490.1 - 0.019 14.5 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding DUF2250 PF10007.9 AIC16491.1 - 0.029 14.5 0.3 1.1 9.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) SUI1 PF01253.22 AIC16492.1 - 4e-13 49.7 0.1 6.5e-13 49.0 0.1 1.4 1 1 1 2 2 2 1 Translation initiation factor SUI1 Img2 PF05046.14 AIC16492.1 - 0.02 15.1 0.0 0.025 14.9 0.0 1.3 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) SRI PF08236.11 AIC16492.1 - 0.091 12.9 0.2 0.12 12.6 0.2 1.2 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain LPD15 PF18828.1 AIC16492.1 - 0.12 12.2 0.1 0.12 12.2 0.1 1.2 1 1 0 1 1 1 0 Large polyvalent-protein-associated domain 15 Trypsin_2 PF13365.6 AIC16493.1 - 1.9e-37 129.5 1.5 3e-37 128.8 1.5 1.3 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 AIC16493.1 - 2.3e-16 59.9 0.3 7e-15 55.1 0.0 2.5 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 AIC16493.1 - 1.9e-13 50.8 0.1 3.5e-13 49.9 0.1 1.4 1 1 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 AIC16493.1 - 1.4e-10 40.8 2.5 1.6e-10 40.7 0.2 2.1 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 AIC16493.1 - 1.4e-05 25.3 0.1 0.00013 22.2 0.0 2.4 2 0 0 2 2 2 1 PDZ domain Tricorn_PDZ PF14685.6 AIC16493.1 - 0.0037 17.2 0.0 0.011 15.7 0.0 1.8 1 0 0 1 1 1 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 AIC16493.1 - 0.0049 15.6 0.3 0.64 8.6 0.2 2.1 2 0 0 2 2 2 2 Peptidase S46 FMN_red PF03358.15 AIC16494.1 - 7.2e-29 100.5 0.0 8.4e-29 100.3 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AIC16494.1 - 3.9e-10 39.8 0.0 4.4e-10 39.6 0.0 1.1 1 0 0 1 1 1 1 Flavodoxin-like fold Flavodoxin_5 PF12724.7 AIC16494.1 - 0.093 13.0 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain Pirin PF02678.16 AIC16495.1 - 3.8e-35 120.1 0.9 7.1e-35 119.3 0.9 1.4 1 0 0 1 1 1 1 Pirin Pirin_C_2 PF17954.1 AIC16495.1 - 5e-19 68.3 1.2 9.8e-19 67.3 0.5 1.8 2 0 0 2 2 2 1 Quercetinase C-terminal cupin domain Cupin_2 PF07883.11 AIC16495.1 - 6.7e-09 35.3 2.4 2.1e-07 30.6 0.6 2.8 3 1 1 4 4 4 2 Cupin domain Pirin_C PF05726.13 AIC16495.1 - 0.00082 19.7 0.1 0.071 13.5 0.1 2.3 2 0 0 2 2 2 1 Pirin C-terminal cupin domain MS_channel PF00924.18 AIC16496.1 - 1.3e-07 31.4 1.7 3.7e-07 29.9 1.7 1.6 1 1 0 1 1 1 1 Mechanosensitive ion channel zf-CSL PF05207.13 AIC16497.1 - 0.0013 18.4 1.5 0.0014 18.3 1.5 1.1 1 0 0 1 1 1 1 CSL zinc finger zinc_ribbon_5 PF13719.6 AIC16497.1 - 0.0028 17.4 2.3 0.0042 16.8 2.3 1.4 1 1 0 1 1 1 1 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 AIC16497.1 - 0.0047 16.9 2.3 0.0061 16.5 2.3 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain RNA_POL_M_15KD PF02150.16 AIC16497.1 - 0.0062 16.4 2.0 0.033 14.1 2.0 2.0 1 1 0 1 1 1 1 RNA polymerases M/15 Kd subunit DUF2072 PF09845.9 AIC16497.1 - 0.023 14.9 0.2 0.028 14.7 0.2 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein TF_Zn_Ribbon PF08271.12 AIC16497.1 - 0.025 14.1 1.9 0.042 13.4 1.9 1.4 1 1 0 1 1 1 0 TFIIB zinc-binding zinc_ribbon_4 PF13717.6 AIC16497.1 - 0.025 14.5 1.8 0.042 13.8 1.8 1.4 1 0 0 1 1 1 0 zinc-ribbon domain zf-RRN7 PF11781.8 AIC16497.1 - 0.059 13.1 0.3 0.059 13.1 0.3 1.8 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 tRNA-synt_1f PF01921.18 AIC16497.1 - 0.11 11.4 0.1 0.11 11.4 0.1 1.0 1 0 0 1 1 1 0 tRNA synthetases class I (K) Lar_restr_allev PF14354.6 AIC16497.1 - 0.11 12.9 3.1 0.17 12.3 3.1 1.4 1 1 0 1 1 1 0 Restriction alleviation protein Lar Zn-ribbon_8 PF09723.10 AIC16497.1 - 0.64 10.2 6.3 1.2 9.4 1.4 2.2 1 1 1 2 2 2 0 Zinc ribbon domain CTP_transf_like PF01467.26 AIC16498.1 - 1.4e-14 54.5 0.0 1.7e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Cytidylyltransferase-like HIGH_NTase1 PF05636.11 AIC16498.1 - 0.0089 15.3 0.0 0.035 13.3 0.0 1.8 2 0 0 2 2 2 1 HIGH Nucleotidyl Transferase Citrate_ly_lig PF08218.11 AIC16498.1 - 0.019 14.6 0.0 0.14 11.8 0.0 2.2 2 1 0 2 2 2 0 Citrate lyase ligase C-terminal domain Pantoate_ligase PF02569.15 AIC16498.1 - 0.049 12.8 0.0 0.058 12.6 0.0 1.2 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase Peripla_BP_1 PF00532.21 AIC16498.1 - 0.056 12.9 0.0 0.087 12.2 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding proteins and sugar binding domain of LacI family Arm_3 PF16186.5 AIC16498.1 - 0.12 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Atypical Arm repeat tRNA-synt_1g PF09334.11 AIC16499.1 - 1.8e-136 454.9 0.1 2.3e-136 454.6 0.1 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AIC16499.1 - 2.9e-17 62.2 0.7 2.1e-08 32.9 0.0 3.9 2 2 1 3 3 3 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AIC16499.1 - 1.4e-13 51.0 0.6 2.2e-13 50.4 0.6 1.3 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AIC16499.1 - 4.1e-11 42.8 0.1 0.00029 20.3 0.1 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AIC16499.1 - 0.00023 20.2 0.0 0.17 10.8 0.0 3.2 3 0 0 3 3 3 1 tRNA synthetases class I (K) DZR PF12773.7 AIC16499.1 - 0.75 9.9 5.2 1.4 9.0 5.2 1.4 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC16499.1 - 3.4 7.2 8.8 16 5.1 2.2 2.5 1 1 1 2 2 2 0 zinc-ribbon domain TF_Zn_Ribbon PF08271.12 AIC16499.1 - 4.2 7.0 6.6 0.86 9.2 2.6 2.0 1 1 0 1 1 1 0 TFIIB zinc-binding Lar_restr_allev PF14354.6 AIC16499.1 - 5 7.6 9.0 38 4.8 0.0 3.5 2 1 0 3 3 3 0 Restriction alleviation protein Lar AdoHcyase PF05221.17 AIC16500.1 - 5.2e-52 176.9 0.0 4.2e-25 88.5 0.1 2.0 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 AIC16500.1 - 1e-49 168.7 0.3 1.8e-49 167.9 0.1 1.6 2 0 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIC16500.1 - 9.3e-10 38.1 0.0 2e-09 37.0 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 AIC16500.1 - 0.00012 21.6 0.0 0.0003 20.4 0.0 1.6 2 0 0 2 2 2 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain AlaDh_PNT_C PF01262.21 AIC16500.1 - 0.0002 20.8 4.6 0.00033 20.0 2.8 2.2 2 1 0 2 2 2 1 Alanine dehydrogenase/PNT, C-terminal domain TrkA_N PF02254.18 AIC16500.1 - 0.0046 17.2 0.1 0.013 15.7 0.1 1.8 1 0 0 1 1 1 1 TrkA-N domain ABC2_membrane_2 PF12679.7 AIC16501.1 - 0.009 15.3 0.2 0.013 14.8 0.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ETRAMP PF09716.10 AIC16501.1 - 1.2 9.3 2.6 2.6 8.2 2.6 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Rieske PF00355.26 AIC16502.1 - 2.3e-16 59.5 0.0 2.6e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIC16502.1 - 9.3e-12 44.8 0.0 1e-11 44.7 0.0 1.0 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain tRNA-synt_1e PF01406.19 AIC16503.1 - 8.3e-125 416.1 0.4 3.6e-124 414.0 0.1 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1g PF09334.11 AIC16503.1 - 1.3e-13 50.4 0.8 2.5e-06 26.5 0.2 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 AIC16503.1 - 4.1e-08 32.0 0.0 1.6e-05 23.4 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) DALR_2 PF09190.11 AIC16503.1 - 1.5e-07 31.8 1.6 4.7e-07 30.2 1.0 2.2 2 0 0 2 2 2 1 DALR domain tRNA-synt_1f PF01921.18 AIC16503.1 - 8e-06 25.0 0.0 0.01 14.7 0.0 2.3 2 0 0 2 2 2 2 tRNA synthetases class I (K) DUF1858 PF08984.11 AIC16503.1 - 0.033 14.4 0.0 0.087 13.0 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) HDOD PF08668.12 AIC16503.1 - 0.043 13.3 0.1 0.28 10.6 0.0 2.2 1 1 1 2 2 2 0 HDOD domain SOAR PF16533.5 AIC16503.1 - 0.17 11.8 1.4 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 STIM1 Orai1-activating region Bactofilin PF04519.13 AIC16504.1 - 0.017 15.4 6.1 0.069 13.5 3.5 2.0 1 1 1 2 2 2 0 Polymer-forming cytoskeletal Lactamase_B_6 PF16661.5 AIC16506.1 - 3.4e-14 52.7 0.0 6.5e-14 51.8 0.0 1.5 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Beta-Casp PF10996.8 AIC16506.1 - 2.3e-13 50.4 0.0 5.5e-13 49.2 0.0 1.7 2 0 0 2 2 2 1 Beta-Casp domain RMMBL PF07521.12 AIC16506.1 - 3.4e-10 39.7 0.0 1.5e-09 37.6 0.0 2.0 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B PF00753.27 AIC16506.1 - 3.1e-09 37.1 0.1 9.4e-07 29.0 0.0 2.2 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIC16506.1 - 1.8e-07 30.9 0.0 6.9e-07 29.0 0.0 1.8 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIC16506.1 - 1.1e-05 25.4 0.0 3.3e-05 23.8 0.0 1.7 1 1 0 1 1 1 1 Beta-lactamase superfamily domain BNR_2 PF13088.6 AIC16507.1 - 7.8e-06 25.4 0.0 4.1 6.6 0.0 4.7 3 2 1 4 4 4 3 BNR repeat-like domain BNR PF02012.20 AIC16507.1 - 0.00022 20.7 13.2 7.4 7.0 0.1 6.7 6 0 0 6 6 6 3 BNR/Asp-box repeat Glyco_hydro_43 PF04616.14 AIC16507.1 - 0.074 12.4 0.2 10 5.3 0.0 3.5 3 1 1 4 4 4 0 Glycosyl hydrolases family 43 Methyltransf_23 PF13489.6 AIC16508.1 - 0.0059 16.5 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC16508.1 - 0.019 14.7 0.0 0.044 13.6 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain MetW PF07021.12 AIC16508.1 - 0.1 12.2 0.0 0.21 11.2 0.0 1.5 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 AIC16509.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain P53_TAD PF08563.11 AIC16510.1 - 0.096 12.2 0.5 0.14 11.7 0.5 1.3 1 0 0 1 1 1 0 P53 transactivation motif Endonuclease_5 PF04493.14 AIC16513.1 - 1.8e-49 168.2 0.0 2.1e-49 167.9 0.0 1.1 1 0 0 1 1 1 1 Endonuclease V DUF99 PF01949.16 AIC16513.1 - 0.0014 18.0 0.0 0.0034 16.8 0.0 1.7 1 1 0 1 1 1 1 Protein of unknown function DUF99 TGT PF01702.18 AIC16514.1 - 1.8e-68 231.3 0.0 2.4e-68 230.9 0.0 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase DUF5591 PF17884.1 AIC16514.1 - 4e-07 30.0 0.0 7e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5591) Lsm_C PF14894.6 AIC16515.1 - 3.3e-20 71.6 0.6 1.5e-19 69.5 0.0 2.1 2 0 0 2 2 2 1 Lsm C-terminal LSM PF01423.22 AIC16515.1 - 2.2e-06 27.3 0.1 4.2e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 LSM domain SM-ATX PF14438.6 AIC16515.1 - 5.2e-05 23.3 0.1 9.3e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 Ataxin 2 SM domain LSM14 PF12701.7 AIC16515.1 - 9.4e-05 22.4 0.1 0.00018 21.6 0.1 1.5 1 0 0 1 1 1 1 Scd6-like Sm domain DUF150_C PF17384.2 AIC16515.1 - 0.0092 16.1 0.1 0.017 15.2 0.1 1.4 1 0 0 1 1 1 1 RimP C-terminal SH3 domain AHSA1 PF08327.11 AIC16516.1 - 0.027 14.7 0.0 0.029 14.6 0.0 1.0 1 0 0 1 1 1 0 Activator of Hsp90 ATPase homolog 1-like protein HEPN_Apea PF18739.1 AIC16518.1 - 9.2e-08 32.4 0.0 4.4e-07 30.3 0.0 2.1 1 1 0 1 1 1 1 Apea-like HEPN RGS-like PF09128.11 AIC16518.1 - 0.11 12.2 0.1 0.37 10.5 0.0 1.7 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain AAA_18 PF13238.6 AIC16519.1 - 1.9e-09 38.1 0.2 2.6e-09 37.7 0.2 1.2 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 AIC16519.1 - 6.2e-05 23.4 0.9 9.2e-05 22.9 0.5 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 AIC16519.1 - 0.0013 18.7 0.2 0.0096 15.8 0.0 2.2 1 1 1 2 2 2 1 NTPase AAA_17 PF13207.6 AIC16519.1 - 0.0017 18.8 1.9 0.0031 17.9 0.9 2.0 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 AIC16519.1 - 0.0075 16.0 0.0 0.012 15.4 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 AIC16519.1 - 0.0095 16.2 0.2 0.041 14.2 0.2 2.1 1 1 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 AIC16519.1 - 0.012 15.8 0.1 6.3 6.9 0.1 2.6 1 1 1 2 2 2 0 Cytidylate kinase-like family MeaB PF03308.16 AIC16519.1 - 0.037 13.0 0.4 0.064 12.2 0.1 1.7 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB APS_kinase PF01583.20 AIC16519.1 - 0.042 13.7 0.2 0.076 12.9 0.2 1.5 1 0 0 1 1 1 0 Adenylylsulphate kinase SKI PF01202.22 AIC16519.1 - 0.064 13.4 0.2 0.44 10.7 0.2 2.3 1 1 0 1 1 1 0 Shikimate kinase KTI12 PF08433.10 AIC16519.1 - 0.068 12.6 0.1 0.12 11.8 0.1 1.3 1 0 0 1 1 1 0 Chromatin associated protein KTI12 AAA_16 PF13191.6 AIC16519.1 - 0.16 12.3 0.1 0.22 11.9 0.1 1.5 1 1 0 1 1 1 0 AAA ATPase domain GATA PF00320.27 AIC16520.1 - 0.0066 16.0 1.3 0.16 11.6 0.1 2.1 2 0 0 2 2 2 1 GATA zinc finger Spt4 PF06093.13 AIC16520.1 - 0.011 15.8 1.8 0.012 15.7 1.8 1.1 1 0 0 1 1 1 0 Spt4/RpoE2 zinc finger zf-RRN7 PF11781.8 AIC16520.1 - 0.027 14.1 1.5 1 9.1 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DUF35_N PF12172.8 AIC16520.1 - 0.092 12.6 0.1 0.092 12.6 0.1 1.7 1 1 0 1 1 1 0 Rubredoxin-like zinc ribbon domain (DUF35_N) zf_C2H2_13 PF18508.1 AIC16520.1 - 2.8 7.6 8.0 0.41 10.3 0.9 2.1 1 1 1 2 2 2 0 Zinc finger domain zinc_ribbon_2 PF13240.6 AIC16521.1 - 2.3e-07 30.3 4.2 4.2e-07 29.5 4.2 1.4 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIC16521.1 - 3.9e-06 26.8 0.8 6.1e-06 26.2 0.8 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC16521.1 - 3.3e-05 23.1 2.3 5e-05 22.6 2.3 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIC16521.1 - 0.00037 21.2 0.2 0.00043 21.0 0.2 1.2 1 0 0 1 1 1 1 zinc-ribbon family UPF0547 PF10571.9 AIC16521.1 - 0.0032 17.5 2.4 0.0099 15.9 2.6 1.7 1 1 1 2 2 2 1 Uncharacterised protein family UPF0547 zf-C4H2 PF10146.9 AIC16521.1 - 0.012 16.0 0.1 0.012 15.9 0.1 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Nudix_N_2 PF14803.6 AIC16521.1 - 0.048 13.6 6.7 1.4 8.9 0.3 2.4 2 0 0 2 2 2 0 Nudix N-terminal RNA_POL_M_15KD PF02150.16 AIC16521.1 - 0.4 10.6 3.8 11 6.1 0.2 3.0 3 0 0 3 3 3 0 RNA polymerases M/15 Kd subunit YhfH PF14149.6 AIC16521.1 - 0.65 10.0 5.7 5 7.2 0.3 2.3 1 1 1 2 2 2 0 YhfH-like protein zf-NADH-PPase PF09297.11 AIC16521.1 - 0.73 9.6 5.0 5.4 6.8 0.1 2.3 1 1 1 2 2 2 0 NADH pyrophosphatase zinc ribbon domain NOB1_Zn_bind PF08772.11 AIC16521.1 - 0.73 10.0 6.3 13 6.0 0.4 2.7 2 1 1 3 3 3 0 Nin one binding (NOB1) Zn-ribbon like zinc_ribbon_2 PF13240.6 AIC16522.1 - 1.1e-05 24.9 3.3 2e-05 24.2 3.3 1.3 1 0 0 1 1 1 1 zinc-ribbon domain DZR PF12773.7 AIC16522.1 - 0.00037 20.4 2.0 0.00057 19.9 2.0 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 AIC16522.1 - 0.00081 18.7 3.4 0.0013 18.1 3.4 1.3 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 AIC16522.1 - 0.0019 18.9 0.2 0.003 18.3 0.2 1.3 1 0 0 1 1 1 1 zinc-ribbon family DUF2116 PF09889.9 AIC16522.1 - 0.0068 16.4 2.3 0.0068 16.4 2.3 1.6 2 0 0 2 2 2 1 Uncharacterized protein containing a Zn-ribbon (DUF2116) CdvA PF18822.1 AIC16522.1 - 0.1 12.4 0.1 0.15 11.9 0.1 1.1 1 0 0 1 1 1 0 CdvA-like coiled-coil domain DHHC PF01529.20 AIC16522.1 - 0.38 10.8 1.9 0.65 10.1 1.2 1.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase UPF0547 PF10571.9 AIC16522.1 - 0.63 10.2 5.2 1.8 8.7 5.3 1.7 1 1 0 1 1 1 0 Uncharacterised protein family UPF0547 DEAD PF00270.29 AIC16523.1 - 4e-53 179.8 0.3 8.1e-52 175.5 0.1 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIC16523.1 - 7e-34 116.5 0.5 9.7e-32 109.6 0.2 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIC16523.1 - 2.2e-07 31.1 0.0 6.1e-07 29.6 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 AIC16523.1 - 0.00056 19.8 0.1 0.0028 17.5 0.0 2.1 1 1 1 2 2 2 1 Helicase Flavi_DEAD PF07652.14 AIC16523.1 - 0.0018 18.3 0.2 0.26 11.3 0.1 2.7 2 1 0 2 2 2 1 Flavivirus DEAD domain UTP25 PF06862.12 AIC16523.1 - 0.0018 17.1 0.1 0.097 11.4 0.0 2.7 2 1 0 2 2 2 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 CMS1 PF14617.6 AIC16523.1 - 0.0034 16.8 0.7 0.0079 15.6 0.5 1.7 1 1 1 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit LuxC PF05893.14 AIC16523.1 - 0.0038 16.3 0.1 0.39 9.7 0.0 2.2 1 1 0 2 2 2 2 Acyl-CoA reductase (LuxC) ERCC3_RAD25_C PF16203.5 AIC16523.1 - 0.015 14.6 0.0 0.021 14.0 0.0 1.1 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase adh_short PF00106.25 AIC16523.1 - 0.024 14.1 0.2 0.064 12.7 0.2 1.7 1 0 0 1 1 1 0 short chain dehydrogenase Peptidase_M66 PF10462.9 AIC16523.1 - 0.08 11.9 0.0 0.08 11.9 0.0 2.4 2 1 0 2 2 1 0 Peptidase M66 CobA_CobO_BtuR PF02572.15 AIC16523.1 - 0.086 13.1 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP PspA_IM30 PF04012.12 AIC16524.1 - 0.0014 18.3 4.5 0.0018 17.9 4.5 1.2 1 0 0 1 1 1 1 PspA/IM30 family ArsA_ATPase PF02374.15 AIC16524.1 - 0.0026 17.0 1.3 0.0032 16.7 1.3 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase DUF2390 PF09523.10 AIC16524.1 - 0.0057 17.0 3.4 0.011 16.0 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2390) Lebercilin PF15619.6 AIC16524.1 - 0.018 14.7 7.9 0.018 14.7 7.9 1.7 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 AIC16524.1 - 0.02 15.1 9.0 0.027 14.7 9.0 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GCIP PF13324.6 AIC16524.1 - 0.036 13.7 2.4 0.046 13.3 2.4 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF812 PF05667.11 AIC16524.1 - 0.04 12.8 7.3 0.048 12.6 7.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) T3SSipB PF16535.5 AIC16524.1 - 0.062 13.8 7.0 0.12 12.9 6.0 1.8 1 1 1 2 2 2 0 Type III cell invasion protein SipB Nup88 PF10168.9 AIC16524.1 - 0.09 10.6 8.0 0.11 10.3 8.0 1.0 1 0 0 1 1 1 0 Nuclear pore component DUF4795 PF16043.5 AIC16524.1 - 0.12 12.0 7.8 0.18 11.4 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Macoilin PF09726.9 AIC16524.1 - 0.12 10.9 9.0 0.15 10.6 9.0 1.0 1 0 0 1 1 1 0 Macoilin family DUF745 PF05335.13 AIC16524.1 - 0.21 11.3 4.7 0.38 10.5 4.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) FliD_N PF02465.18 AIC16524.1 - 0.23 12.2 7.7 0.52 11.0 6.4 2.1 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus TMPIT PF07851.13 AIC16524.1 - 0.38 9.9 3.5 0.49 9.6 3.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein YabA PF06156.13 AIC16524.1 - 0.38 11.4 3.6 0.58 10.8 3.6 1.4 1 0 0 1 1 1 0 Initiation control protein YabA Gram_pos_anchor PF00746.21 AIC16524.1 - 0.4 10.7 0.1 0.4 10.7 0.1 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif DUF1664 PF07889.12 AIC16524.1 - 0.43 10.6 9.0 1.5 8.8 8.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) COG2 PF06148.11 AIC16524.1 - 0.65 10.1 6.7 2.1 8.4 6.5 1.9 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4715 PF15835.5 AIC16524.1 - 0.73 9.9 5.4 3.3 7.8 5.2 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4715) HrpB7 PF09486.10 AIC16524.1 - 1 9.8 8.6 16 5.9 6.0 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) GvpL_GvpF PF06386.11 AIC16524.1 - 1.1 9.2 3.8 1.5 8.7 3.8 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF4446 PF14584.6 AIC16524.1 - 1.7 8.6 6.4 5 7.1 4.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Exonuc_VII_L PF02601.15 AIC16524.1 - 1.8 8.1 7.8 2.7 7.5 7.6 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit CENP-H PF05837.12 AIC16524.1 - 6.3 7.2 11.7 13 6.2 11.7 1.6 1 1 0 1 1 1 0 Centromere protein H (CENP-H) DUF4988 PF16378.5 AIC16525.1 - 0.016 14.9 0.4 0.017 14.8 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function bZIP_2 PF07716.15 AIC16525.1 - 0.016 15.3 0.7 0.45 10.6 0.2 2.1 2 0 0 2 2 2 0 Basic region leucine zipper RHH_1 PF01402.21 AIC16526.1 - 5.7e-06 26.1 0.0 8.6e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Ribbon-helix-helix protein, copG family UBA_2 PF08587.11 AIC16526.1 - 0.078 13.1 0.0 0.097 12.8 0.0 1.2 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) DDE_Tnp_IS240 PF13610.6 AIC16527.1 - 5.8e-25 88.1 0.8 9.9e-25 87.4 0.8 1.4 1 0 0 1 1 1 1 DDE domain rve_3 PF13683.6 AIC16527.1 - 2.1e-07 30.6 0.0 5.2e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_IS66 PF03050.14 AIC16527.1 - 1.5e-05 24.6 0.3 3.7e-05 23.3 0.0 1.7 2 1 0 3 3 3 1 Transposase IS66 family rve PF00665.26 AIC16527.1 - 1.7e-05 25.0 0.1 5.5e-05 23.3 0.1 1.9 1 1 0 1 1 1 1 Integrase core domain Transposase_mut PF00872.18 AIC16527.1 - 0.003 16.5 0.2 0.007 15.3 0.0 1.6 2 0 0 2 2 2 1 Transposase, Mutator family Zn_Tnp_IS1 PF03811.13 AIC16527.1 - 0.035 13.8 5.2 0.069 12.9 5.2 1.5 1 0 0 1 1 1 0 InsA N-terminal domain DNA_RNApol_7kD PF03604.13 AIC16527.1 - 0.19 11.4 7.5 3.6 7.4 0.4 2.5 1 1 1 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit MIG-14_Wnt-bd PF06664.12 AIC16529.1 - 0.0006 19.1 7.6 0.0006 19.1 7.6 1.7 1 1 1 2 2 2 1 Wnt-binding factor required for Wnt secretion TerC PF03741.16 AIC16529.1 - 0.0027 17.4 0.2 0.4 10.3 0.6 2.4 1 1 1 2 2 2 2 Integral membrane protein TerC family DUF3054 PF11255.8 AIC16529.1 - 0.042 14.4 1.8 0.042 14.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) DUF1317 PF07026.11 AIC16529.1 - 0.17 11.7 0.1 0.41 10.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1317) DUF3810 PF12725.7 AIC16529.1 - 0.22 10.8 3.0 1.7 8.0 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF2684 PF10885.8 AIC16529.1 - 0.37 11.0 4.0 0.23 11.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) Bax1-I PF01027.20 AIC16529.1 - 0.42 10.4 12.1 0.43 10.4 0.2 3.1 1 1 2 3 3 3 0 Inhibitor of apoptosis-promoting Bax1 DUF4271 PF14093.6 AIC16529.1 - 2.4 8.0 13.8 0.23 11.4 2.8 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4271) CYTH PF01928.21 AIC16530.1 - 0.13 12.1 0.0 0.14 12.1 0.0 1.0 1 0 0 1 1 1 0 CYTH domain ATPase PF06745.13 AIC16533.1 - 8.7e-20 71.0 0.0 1.5e-19 70.3 0.0 1.3 1 0 0 1 1 1 1 KaiC Guanylate_cyc PF00211.20 AIC16533.1 - 0.0003 20.5 0.0 0.00058 19.5 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain IstB_IS21 PF01695.17 AIC16533.1 - 0.0053 16.5 0.0 0.0094 15.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 AIC16533.1 - 0.0071 16.7 0.1 0.013 15.9 0.1 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 AIC16533.1 - 0.0086 16.1 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 AIC16533.1 - 0.0097 15.7 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_25 PF13481.6 AIC16533.1 - 0.011 15.3 0.1 0.038 13.6 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AIC16533.1 - 0.022 15.0 0.0 0.043 14.1 0.0 1.6 1 1 0 1 1 1 0 AAA domain GvpD PF07088.11 AIC16533.1 - 0.024 13.3 0.0 0.2 10.2 0.0 1.9 1 1 0 1 1 1 0 GvpD gas vesicle protein LIM PF00412.22 AIC16533.1 - 0.056 13.7 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 LIM domain PAXNEB PF05625.11 AIC16533.1 - 0.061 12.5 0.0 0.095 11.8 0.0 1.2 1 0 0 1 1 1 0 PAXNEB protein AAA_7 PF12775.7 AIC16533.1 - 0.12 11.9 0.0 0.22 11.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 AIC16533.1 - 0.13 12.6 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zot PF05707.12 AIC16533.1 - 0.18 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) AAA_31 PF13614.6 AIC16534.1 - 2.8e-19 69.7 0.0 6.4e-19 68.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 AIC16534.1 - 2.4e-14 53.5 0.0 3.3e-14 53.0 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 AIC16534.1 - 9.8e-13 48.1 0.0 1.2e-11 44.6 0.0 2.3 3 0 0 3 3 3 1 NUBPL iron-transfer P-loop NTPase MipZ PF09140.11 AIC16534.1 - 5.2e-09 35.8 0.0 2.4e-07 30.3 0.0 2.1 1 1 0 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.15 AIC16534.1 - 0.00013 21.3 0.1 0.0002 20.7 0.1 1.5 1 1 0 1 1 1 1 Anion-transporting ATPase VirC1 PF07015.11 AIC16534.1 - 0.00015 21.1 0.6 0.00033 20.0 0.1 1.7 2 0 0 2 2 2 1 VirC1 protein Fer4_NifH PF00142.18 AIC16534.1 - 0.004 16.6 0.0 0.013 14.9 0.0 1.7 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family SRP54 PF00448.22 AIC16534.1 - 0.0042 16.7 0.2 0.011 15.4 0.1 1.6 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain CBP_BcsQ PF06564.12 AIC16534.1 - 0.0068 15.9 0.0 0.056 12.9 0.0 2.0 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ CLP1_P PF16575.5 AIC16534.1 - 0.014 15.2 0.1 0.042 13.6 0.0 1.8 2 1 1 3 3 3 0 mRNA cleavage and polyadenylation factor CLP1 P-loop APS_kinase PF01583.20 AIC16534.1 - 0.046 13.6 0.0 0.085 12.7 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase HTH_5 PF01022.20 AIC16535.1 - 3.6e-08 33.2 0.0 5e-08 32.7 0.0 1.2 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family TrmB PF01978.19 AIC16535.1 - 0.00044 20.1 0.0 0.00063 19.6 0.0 1.1 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 AIC16535.1 - 0.00077 19.5 0.0 0.0012 18.9 0.0 1.5 1 1 0 1 1 1 1 Helix-turn-helix domain HTH_29 PF13551.6 AIC16535.1 - 0.0091 16.0 0.0 0.019 15.0 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn helix Phage_rep_O PF04492.13 AIC16535.1 - 0.017 15.7 0.0 0.023 15.3 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage replication protein O FaeA PF04703.12 AIC16535.1 - 0.017 15.5 0.0 0.028 14.8 0.0 1.3 1 0 0 1 1 1 0 FaeA-like protein MarR PF01047.22 AIC16535.1 - 0.026 14.5 0.0 0.043 13.8 0.0 1.3 1 0 0 1 1 1 0 MarR family HTH_24 PF13412.6 AIC16535.1 - 0.056 13.0 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding HTH_45 PF14947.6 AIC16535.1 - 0.087 12.8 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Winged helix-turn-helix MarR_2 PF12802.7 AIC16535.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.5 1 1 0 1 1 1 0 MarR family DprA_WH PF17782.1 AIC16535.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 DprA winged helix domain DUF2614 PF11023.8 AIC16536.1 - 0.28 11.3 3.5 0.34 11.0 3.5 1.2 1 0 0 1 1 1 0 Zinc-ribbon containing domain TRIQK PF15168.6 AIC16536.1 - 1.2 9.1 2.9 0.58 10.1 0.3 1.8 1 1 1 2 2 2 0 Triple QxxK/R motif-containing protein family DsbD PF02683.15 AIC16537.1 - 2.3e-47 161.6 17.1 3.2e-36 125.2 14.4 2.0 2 0 0 2 2 2 2 Cytochrome C biogenesis protein transmembrane region DsbD_2 PF13386.6 AIC16537.1 - 2.6e-06 27.5 18.1 4.4e-06 26.8 18.1 1.3 1 0 0 1 1 1 1 Cytochrome C biogenesis protein transmembrane region DUF3119 PF11317.8 AIC16537.1 - 8.9 6.6 8.6 0.65 10.3 0.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3119) Thioredoxin_10 PF17991.1 AIC16538.1 - 2e-36 125.6 0.0 3.3e-36 124.9 0.0 1.4 1 0 0 1 1 1 1 Thioredoxin like C-terminal domain AhpC-TSA PF00578.21 AIC16538.1 - 5.4e-16 58.6 0.0 1e-15 57.8 0.0 1.4 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC16538.1 - 8.9e-13 48.2 0.0 1.5e-12 47.5 0.0 1.3 1 0 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 AIC16538.1 - 2.5e-08 34.1 0.1 4.7e-08 33.3 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like GSHPx PF00255.19 AIC16538.1 - 0.0001 21.9 0.0 0.0002 20.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase Thioredoxin PF00085.20 AIC16538.1 - 0.045 13.8 0.0 0.085 12.9 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin DZR PF12773.7 AIC16539.1 - 0.0025 17.8 6.4 0.0078 16.2 6.5 1.7 1 1 0 1 1 1 1 Double zinc ribbon zf-C2H2_4 PF13894.6 AIC16539.1 - 0.51 11.3 0.1 0.51 11.3 0.1 3.8 4 1 1 5 5 5 0 C2H2-type zinc finger NMD3 PF04981.13 AIC16539.1 - 0.61 9.5 6.3 1.5 8.2 1.2 2.1 2 0 0 2 2 2 0 NMD3 family Ribosomal_S27 PF01599.19 AIC16539.1 - 0.91 9.7 6.9 0.25 11.5 1.1 2.3 2 0 0 2 2 2 0 Ribosomal protein S27a XPA_N PF01286.18 AIC16539.1 - 2.4 8.3 10.3 2.3 8.4 2.2 3.6 3 1 0 3 3 3 0 XPA protein N-terminal zinc_ribbon_2 PF13240.6 AIC16539.1 - 2.4 8.0 12.5 2 8.3 0.1 3.5 4 0 0 4 4 4 0 zinc-ribbon domain Ribosomal_L37e PF01907.19 AIC16539.1 - 2.9 8.1 10.1 6.3 7.0 2.9 2.3 1 1 1 2 2 2 0 Ribosomal protein L37e Zn-ribbon_8 PF09723.10 AIC16539.1 - 3.3 7.9 9.0 3 8.1 4.4 2.7 2 1 0 2 2 2 0 Zinc ribbon domain zinc_ribbon_9 PF14369.6 AIC16539.1 - 4.2 7.7 0.0 4.2 7.7 0.0 3.2 3 1 0 3 3 3 0 zinc-ribbon PyrI PF01948.18 AIC16540.1 - 3.9e-32 110.4 2.2 6.6e-32 109.6 2.2 1.4 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, allosteric domain PyrI_C PF02748.15 AIC16540.1 - 9.7e-17 60.6 1.5 1.7e-16 59.9 1.5 1.4 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain Saf_2TM PF18303.1 AIC16540.1 - 0.11 12.1 0.4 0.47 10.0 0.1 1.9 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain MG2 PF01835.19 AIC16542.1 - 7.8e-06 26.3 0.0 0.00039 20.8 0.0 2.3 2 0 0 2 2 2 1 MG2 domain He_PIG PF05345.12 AIC16542.1 - 0.1 12.8 0.1 1.8 8.8 0.0 2.9 3 1 0 3 3 3 0 Putative Ig domain Lactamase_B_2 PF12706.7 AIC16544.1 - 2.2e-08 33.9 0.0 3.3e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 AIC16544.1 - 0.0075 16.2 0.0 0.026 14.4 0.0 1.8 1 1 1 2 2 2 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AIC16544.1 - 0.021 14.8 0.2 0.18 11.8 0.1 2.2 2 0 0 2 2 2 0 Metallo-beta-lactamase superfamily DUF2207 PF09972.9 AIC16545.1 - 0.37 9.5 1.1 0.42 9.3 1.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FbpA PF05833.11 AIC16546.1 - 1.3e-31 109.9 0.3 1.8e-31 109.4 0.3 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) NFACT-R_1 PF05670.13 AIC16546.1 - 3.5e-23 82.3 0.0 9.8e-23 80.9 0.0 1.8 1 0 0 1 1 1 1 NFACT protein RNA binding domain CbbQ_C PF08406.10 AIC16546.1 - 0.022 15.0 0.7 0.095 13.0 0.1 2.4 2 0 0 2 2 2 0 CbbQ/NirQ/NorQ C-terminal DUF4337 PF14235.6 AIC16546.1 - 0.36 10.9 5.6 1.8 8.7 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) baeRF_family2 PF18844.1 AIC16546.1 - 1 9.4 5.7 0.77 9.8 3.4 2.1 2 0 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 2 CBS PF00571.28 AIC16547.1 - 3.2e-23 81.9 5.0 3.6e-12 46.6 0.8 2.4 2 0 0 2 2 2 2 CBS domain TF_Zn_Ribbon PF08271.12 AIC16547.1 - 0.011 15.2 2.7 0.023 14.2 1.8 1.9 2 0 0 2 2 2 0 TFIIB zinc-binding Rubredoxin_2 PF18073.1 AIC16547.1 - 0.17 11.6 0.3 0.17 11.6 0.3 1.8 2 0 0 2 2 2 0 Rubredoxin metal binding domain Acetyltransf_8 PF13523.6 AIC16547.1 - 0.17 11.5 0.0 0.33 10.6 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Mut7-C PF01927.16 AIC16548.1 - 1.7e-40 138.5 0.0 1.9e-40 138.3 0.0 1.0 1 0 0 1 1 1 1 Mut7-C RNAse domain DUF5615 PF18480.1 AIC16548.1 - 4e-10 39.3 0.0 6.3e-10 38.7 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5615) PIN_10 PF18478.1 AIC16548.1 - 0.0002 21.5 0.0 0.00071 19.7 0.0 1.8 1 1 0 1 1 1 1 PIN like domain PIN_9 PF18477.1 AIC16548.1 - 0.0088 16.3 0.0 0.014 15.7 0.0 1.3 1 0 0 1 1 1 1 PIN like domain SpoU_sub_bind PF08032.12 AIC16548.1 - 0.084 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 RNA 2'-O ribose methyltransferase substrate binding DUF188 PF02639.14 AIC16548.1 - 0.12 12.0 0.0 0.17 11.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 vATP-synt_E PF01991.18 AIC16549.1 - 7.6e-21 74.4 9.1 1.9e-20 73.2 8.3 1.7 1 1 1 2 2 2 1 ATP synthase (E/31 kDa) subunit DUF4407 PF14362.6 AIC16549.1 - 0.021 14.2 4.1 0.026 13.9 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FliH PF02108.16 AIC16549.1 - 0.037 14.1 2.5 0.27 11.3 1.9 2.3 1 1 0 1 1 1 0 Flagellar assembly protein FliH Exonuc_VII_L PF02601.15 AIC16549.1 - 0.076 12.6 2.3 0.085 12.4 2.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5301 PF17225.3 AIC16549.1 - 0.087 13.3 0.2 0.087 13.3 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5300) YkyA PF10368.9 AIC16549.1 - 0.29 10.8 8.5 0.11 12.1 5.5 1.8 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein V-ATPase_G_2 PF16999.5 AIC16549.1 - 0.42 11.0 10.1 0.4 11.1 8.0 2.0 2 1 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit APG6_N PF17675.1 AIC16549.1 - 0.51 10.9 9.3 3.2 8.3 8.1 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region ATP-synt_ab PF00006.25 AIC16550.1 - 2e-92 308.7 0.0 2.6e-92 308.3 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 AIC16550.1 - 1.4e-41 141.2 0.0 2.4e-41 140.4 0.0 1.4 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 AIC16550.1 - 9.4e-15 54.9 1.1 2.6e-14 53.5 0.3 2.2 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain AAA_22 PF13401.6 AIC16550.1 - 0.044 14.0 0.0 0.095 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AIC16550.1 - 0.22 11.2 0.4 3.6 7.3 0.1 2.3 2 0 0 2 2 2 0 AAA domain ATP-synt_ab PF00006.25 AIC16551.1 - 3.9e-68 229.3 0.0 5.7e-68 228.7 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 AIC16551.1 - 1.5e-09 38.2 1.4 3.7e-09 37.0 1.4 1.7 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain HAS-barrel PF09378.10 AIC16551.1 - 0.0055 16.8 0.7 0.026 14.6 0.6 2.2 2 0 0 2 2 2 1 HAS barrel domain T3SS_ATPase_C PF18269.1 AIC16551.1 - 0.098 12.5 0.0 4.6 7.2 0.0 2.4 2 0 0 2 2 2 0 T3SS EscN ATPase C-terminal domain ATP-synt_D PF01813.17 AIC16552.1 - 7.6e-48 163.0 6.8 8.8e-48 162.7 6.8 1.0 1 0 0 1 1 1 1 ATP synthase subunit D RNA_binding PF01877.17 AIC16552.1 - 0.05 13.9 7.3 0.47 10.7 0.8 2.2 2 0 0 2 2 2 0 RNA binding Skp1_POZ PF03931.15 AIC16552.1 - 0.054 13.7 0.3 5.2 7.3 0.0 2.6 2 0 0 2 2 2 0 Skp1 family, tetramerisation domain DUF3958 PF13125.6 AIC16553.1 - 0.0042 17.3 1.7 0.0044 17.2 1.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3958) ATP-synt_C PF00137.21 AIC16554.1 - 2.5e-16 59.8 17.8 2.5e-16 59.8 17.8 1.8 2 0 0 2 2 2 1 ATP synthase subunit C DUF4064 PF13273.6 AIC16554.1 - 0.014 15.7 7.1 0.014 15.7 7.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) V_ATPase_I PF01496.19 AIC16555.1 - 8.5e-22 76.9 0.6 1.4e-16 59.7 0.0 3.3 3 1 0 3 3 3 2 V-type ATPase 116kDa subunit family PilN PF05137.13 AIC16555.1 - 0.0036 17.4 0.0 0.0083 16.2 0.0 1.6 1 0 0 1 1 1 1 Fimbrial assembly protein (PilN) DUF1192 PF06698.11 AIC16555.1 - 0.0047 17.0 3.0 0.007 16.4 1.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Dynamitin PF04912.14 AIC16555.1 - 0.0061 15.9 1.8 0.0088 15.4 1.8 1.1 1 0 0 1 1 1 1 Dynamitin PKcGMP_CC PF16808.5 AIC16555.1 - 0.046 13.6 0.8 0.13 12.1 0.8 1.7 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Zn_ribbon_2 PF12674.7 AIC16556.1 - 1.8e-19 70.2 0.0 2e-19 70.0 0.0 1.0 1 0 0 1 1 1 1 Putative zinc ribbon domain vATP-synt_AC39 PF01992.16 AIC16557.1 - 6.5e-55 187.0 5.0 7.4e-55 186.8 5.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit RTX_C PF08339.10 AIC16557.1 - 0.009 16.1 0.2 0.64 10.1 0.1 2.3 2 0 0 2 2 2 2 RTX C-terminal domain PP1_inhibitor PF05361.12 AIC16557.1 - 0.048 13.7 0.0 0.1 12.6 0.0 1.5 1 0 0 1 1 1 0 PKC-activated protein phosphatase-1 inhibitor DUF3385 PF11865.8 AIC16558.1 - 0.06 13.3 0.3 0.078 12.9 0.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3385) DivIC PF04977.15 AIC16560.1 - 0.13 12.1 0.6 0.25 11.1 0.6 1.5 1 0 0 1 1 1 0 Septum formation initiator DUF5518 PF17647.1 AIC16561.1 - 0.00033 20.8 8.5 0.0004 20.5 8.5 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5518) RseC_MucC PF04246.12 AIC16561.1 - 2.1 8.3 5.6 0.5 10.3 1.4 1.8 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Tail_VII PF17091.5 AIC16561.1 - 2.1 8.3 6.3 0.29 11.0 0.9 2.3 3 0 0 3 3 3 0 Inovirus G7P protein Rab5ip PF07019.12 AIC16561.1 - 9.2 6.9 8.0 26 5.5 5.1 2.3 1 1 1 2 2 2 0 Rab5-interacting protein (Rab5ip) Methyltransf_31 PF13847.6 AIC16562.1 - 1.1e-13 51.2 0.2 2.5e-13 50.1 0.1 1.5 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC16562.1 - 4.5e-11 43.3 0.3 1.4e-10 41.7 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase domain PrmA PF06325.13 AIC16562.1 - 7.9e-10 38.6 0.9 9.6e-10 38.3 0.9 1.1 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 AIC16562.1 - 1.3e-08 35.4 0.2 3.1e-08 34.1 0.1 1.7 2 0 0 2 2 1 1 Methyltransferase domain MTS PF05175.14 AIC16562.1 - 1.5e-08 34.3 0.2 6.1e-08 32.4 0.2 2.0 1 1 0 1 1 1 1 Methyltransferase small domain PCMT PF01135.19 AIC16562.1 - 1.7e-08 34.5 0.2 2.1e-08 34.2 0.2 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 AIC16562.1 - 2.8e-07 30.1 0.1 3.8e-07 29.7 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase GCD14 PF08704.10 AIC16562.1 - 4.9e-07 29.7 0.0 7.2e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_12 PF08242.12 AIC16562.1 - 1.5e-06 28.9 0.1 2.9e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_24 PF13578.6 AIC16562.1 - 6.4e-06 27.1 0.0 9.4e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 AIC16562.1 - 1.3e-05 25.2 0.2 1.8e-05 24.7 0.2 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC16562.1 - 1.4e-05 24.6 0.2 1.8e-05 24.2 0.2 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Cons_hypoth95 PF03602.15 AIC16562.1 - 0.00011 21.8 0.0 0.00014 21.6 0.0 1.2 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_3 PF01596.17 AIC16562.1 - 0.00019 20.7 0.1 0.00036 19.8 0.1 1.5 1 1 0 1 1 1 1 O-methyltransferase Methyltransf_23 PF13489.6 AIC16562.1 - 0.00096 19.0 0.0 0.002 18.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 AIC16562.1 - 0.0017 18.4 0.0 0.0024 17.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltr_RsmB-F PF01189.17 AIC16562.1 - 0.002 17.8 0.1 0.04 13.6 0.0 2.2 2 0 0 2 2 2 1 16S rRNA methyltransferase RsmB/F Methyltransf_5 PF01795.19 AIC16562.1 - 0.0025 17.3 0.1 0.026 14.0 0.0 2.0 1 1 1 2 2 2 1 MraW methylase family Methyltransf_15 PF09445.10 AIC16562.1 - 0.0026 17.4 0.0 0.0034 17.0 0.0 1.2 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase UPF0020 PF01170.18 AIC16562.1 - 0.003 17.3 0.8 0.098 12.3 0.7 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Met_10 PF02475.16 AIC16562.1 - 0.0034 17.2 0.0 0.0047 16.7 0.0 1.2 1 0 0 1 1 1 1 Met-10+ like-protein AviRa PF11599.8 AIC16562.1 - 0.01 15.3 0.0 0.016 14.7 0.0 1.3 1 0 0 1 1 1 1 RRNA methyltransferase AviRa NodS PF05401.11 AIC16562.1 - 0.031 13.9 0.1 0.065 12.8 0.0 1.6 1 1 0 2 2 2 0 Nodulation protein S (NodS) Spermine_synth PF01564.17 AIC16562.1 - 0.054 12.9 0.1 0.091 12.2 0.0 1.4 1 1 0 1 1 1 0 Spermine/spermidine synthase domain RrnaAD PF00398.20 AIC16562.1 - 0.063 12.3 0.0 0.09 11.8 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase Methyltransf_4 PF02390.17 AIC16562.1 - 0.065 12.7 0.1 1.2 8.5 0.0 2.1 2 0 0 2 2 2 0 Putative methyltransferase POR PF01558.18 AIC16562.1 - 0.074 13.1 0.1 0.15 12.1 0.1 1.5 1 1 1 2 2 2 0 Pyruvate ferredoxin/flavodoxin oxidoreductase DOT1 PF08123.13 AIC16562.1 - 0.089 12.3 0.2 0.25 10.8 0.1 1.7 2 0 0 2 2 2 0 Histone methylation protein DOT1 Methyltransf_PK PF05891.12 AIC16562.1 - 0.1 12.1 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase N6_N4_Mtase PF01555.18 AIC16563.1 - 2.4e-42 145.2 0.0 3e-42 144.9 0.0 1.0 1 0 0 1 1 1 1 DNA methylase Myc_target_1 PF15179.6 AIC16564.1 - 0.41 10.5 1.8 0.45 10.4 1.8 1.1 1 0 0 1 1 1 0 Myc target protein 1 OppC_N PF12911.7 AIC16564.1 - 2.6 8.1 7.1 2.2 8.3 5.4 1.7 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Cation_efflux PF01545.21 AIC16565.1 - 6.3e-46 156.6 3.1 8.5e-46 156.2 3.1 1.2 1 0 0 1 1 1 1 Cation efflux family DUF1206 PF06724.11 AIC16565.1 - 3.3 7.9 0.0 3.3 7.9 0.0 3.8 4 1 0 4 4 4 0 Domain of Unknown Function (DUF1206) OppC_N PF12911.7 AIC16566.1 - 4.9 7.2 8.3 0.86 9.6 0.2 3.6 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C Pox_P35 PF03213.14 AIC16570.1 - 0.0028 17.0 0.0 0.0034 16.7 0.0 1.0 1 0 0 1 1 1 1 Poxvirus P35 protein VTC PF09359.10 AIC16570.1 - 0.049 13.0 0.0 0.06 12.7 0.0 1.0 1 0 0 1 1 1 0 VTC domain zf-C2H2_3rep PF18868.1 AIC16570.1 - 0.067 13.9 0.0 0.079 13.6 0.0 1.1 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats V_ATPase_I_N PF18670.1 AIC16570.1 - 0.16 12.4 0.2 0.24 11.8 0.2 1.3 1 0 0 1 1 1 0 V-type ATPase subunit I, N-terminal domain Putative_PNPOx PF01243.20 AIC16571.1 - 1.3e-06 28.4 0.0 1.8e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase F420H2_quin_red PF04075.14 AIC16571.1 - 0.0013 18.9 0.0 0.0017 18.5 0.0 1.3 1 1 0 1 1 1 1 F420H(2)-dependent quinone reductase Pyridox_ox_2 PF12900.7 AIC16571.1 - 0.016 15.2 0.0 0.019 14.9 0.0 1.4 1 1 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase ApoLp-III PF07464.11 AIC16573.1 - 0.0021 18.1 5.0 0.0033 17.5 3.6 1.8 1 1 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) DUF4633 PF15464.6 AIC16573.1 - 0.017 15.3 3.5 0.017 15.3 3.5 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4633) Mt_ATP-synt_D PF05873.12 AIC16573.1 - 0.031 14.1 4.2 0.048 13.5 3.5 1.7 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) PilM PF07419.12 AIC16573.1 - 0.061 13.5 1.4 0.11 12.6 1.4 1.6 1 1 0 1 1 1 0 PilM Laminin_II PF06009.12 AIC16573.1 - 0.076 13.0 6.4 0.26 11.3 2.3 2.2 2 0 0 2 2 2 0 Laminin Domain II Apolipoprotein PF01442.18 AIC16573.1 - 0.17 11.7 12.8 0.13 12.1 6.6 2.1 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF648 PF04890.13 AIC16573.1 - 0.18 11.5 1.2 0.32 10.7 1.2 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF648) Fzo_mitofusin PF04799.13 AIC16573.1 - 0.21 11.1 4.5 0.19 11.3 2.2 1.9 1 1 1 2 2 2 0 fzo-like conserved region Atg14 PF10186.9 AIC16573.1 - 0.26 10.3 6.1 0.3 10.1 6.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1543 PF07566.12 AIC16573.1 - 0.26 11.0 2.9 4.8 7.0 0.2 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1543) DUF1664 PF07889.12 AIC16573.1 - 0.5 10.4 5.6 0.6 10.2 4.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF883 PF05957.13 AIC16573.1 - 0.5 11.0 13.6 0.6 10.7 1.6 3.2 2 2 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF4407 PF14362.6 AIC16573.1 - 0.59 9.4 12.8 11 5.2 12.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) GT-D PF08759.11 AIC16573.1 - 0.82 9.3 4.8 1.2 8.8 3.2 1.9 1 1 1 2 2 2 0 Glycosyltransferase GT-D fold Med9 PF07544.13 AIC16573.1 - 1 9.5 6.2 0.43 10.7 2.9 2.1 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF1043 PF06295.12 AIC16573.1 - 1 9.4 6.9 10 6.2 6.9 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) HisKA_3 PF07730.13 AIC16573.1 - 1.9 9.1 10.8 3.8 8.1 1.8 3.5 2 2 2 4 4 4 0 Histidine kinase DUF1484 PF07363.11 AIC16573.1 - 2 9.4 6.9 0.25 12.3 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1484) DUF2229 PF09989.9 AIC16573.1 - 2.9 7.5 6.5 1.1 8.9 1.0 2.1 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) YtxH PF12732.7 AIC16573.1 - 4.2 8.0 5.8 20 5.8 1.8 2.9 2 1 0 2 2 2 0 YtxH-like protein PepSY PF03413.19 AIC16574.1 - 0.0032 18.0 0.6 0.0032 18.0 0.6 1.8 2 0 0 2 2 2 1 Peptidase propeptide and YPEB domain BAP PF06639.11 AIC16574.1 - 0.87 10.0 8.2 0.18 12.2 3.3 2.1 1 1 2 3 3 3 0 Basal layer antifungal peptide (BAP) MSP1a PF11670.8 AIC16574.1 - 4.4 6.5 8.2 6.6 5.9 8.2 1.2 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) DUF2267 PF10025.9 AIC16575.1 - 2.1e-09 37.7 0.1 2.5e-09 37.5 0.1 1.0 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2267) IF2_N PF04760.15 AIC16575.1 - 0.00052 19.8 1.2 0.0075 16.1 1.0 2.3 2 0 0 2 2 2 1 Translation initiation factor IF-2, N-terminal region Bac_DNA_binding PF00216.21 AIC16575.1 - 0.00052 20.2 3.4 0.025 14.8 0.1 2.2 2 0 0 2 2 2 2 Bacterial DNA-binding protein SLM4 PF16818.5 AIC16575.1 - 0.0067 16.4 0.8 0.0073 16.3 0.8 1.1 1 0 0 1 1 1 1 Protein SLM4 Tam41_Mmp37 PF09139.11 AIC16575.1 - 0.035 13.5 1.5 0.041 13.3 1.5 1.1 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial DUF937 PF06078.11 AIC16575.1 - 0.06 14.0 3.8 0.44 11.2 3.8 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF937) DUF2780 PF11075.8 AIC16575.1 - 0.084 13.0 6.8 0.67 10.1 6.8 2.2 1 1 0 1 1 1 0 Protein of unknown function VcgC/VcgE (DUF2780) Lactamase_B PF00753.27 AIC16578.1 - 6.7e-08 32.8 0.1 1.6e-07 31.5 0.1 1.9 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 AIC16578.1 - 4.7e-07 29.5 0.1 6.9e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain TFIIS_C PF01096.18 AIC16579.1 - 0.044 13.6 0.1 0.06 13.2 0.1 1.3 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS) RNHCP PF12647.7 AIC16579.1 - 0.058 13.4 0.1 0.059 13.4 0.1 1.1 1 0 0 1 1 1 0 RNHCP domain zf-RanBP PF00641.18 AIC16579.1 - 0.13 11.6 1.5 0.36 10.2 0.4 1.9 1 1 1 2 2 2 0 Zn-finger in Ran binding protein and others NPM1-C PF16276.5 AIC16582.1 - 0.22 11.5 0.7 0.8 9.7 0.7 2.2 1 1 0 1 1 1 0 Nucleophosmin C-terminal domain MerR-DNA-bind PF09278.11 AIC16582.1 - 0.42 11.2 3.8 2.4 8.7 0.0 2.3 2 1 1 3 3 3 0 MerR, DNA binding Copper-bind PF00127.20 AIC16584.1 - 1.2e-08 35.2 0.8 0.0026 18.2 0.1 2.5 2 2 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC16584.1 - 6.7e-05 22.9 1.3 0.016 15.3 0.1 3.2 2 2 0 2 2 2 2 Cupredoxin-like domain AbiEi_1 PF09407.10 AIC16585.1 - 6.6e-11 42.7 0.0 1.1e-10 42.0 0.0 1.3 1 0 0 1 1 1 1 AbiEi antitoxin C-terminal domain AbiEi_4 PF13338.6 AIC16585.1 - 5.1e-07 29.7 0.0 1e-06 28.8 0.0 1.5 1 0 0 1 1 1 1 Transcriptional regulator, AbiEi antitoxin AbiEii PF08843.11 AIC16586.1 - 3.8e-29 102.3 0.0 5.2e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Nucleotidyl transferase AbiEii toxin, Type IV TA system Lon_2 PF13337.6 AIC16586.1 - 0.066 11.7 0.1 0.084 11.4 0.1 1.1 1 0 0 1 1 1 0 Putative ATP-dependent Lon protease BiPBP_C PF06832.12 AIC16587.1 - 0.0051 16.8 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 Penicillin-Binding Protein C-terminus Family Big_7 PF17957.1 AIC16587.1 - 0.011 16.4 0.0 0.024 15.4 0.0 1.6 1 1 0 1 1 1 0 Bacterial Ig domain GATase PF00117.28 AIC16588.1 - 5.2e-45 153.6 0.0 9.6e-45 152.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 AIC16588.1 - 5.3e-35 119.3 0.1 1.1e-34 118.3 0.1 1.6 1 0 0 1 1 1 1 GMP synthase C terminal domain NAD_synthase PF02540.17 AIC16588.1 - 4e-10 39.2 0.4 2.9e-05 23.3 0.0 2.3 2 0 0 2 2 2 2 NAD synthase Peptidase_C26 PF07722.13 AIC16588.1 - 1.6e-09 37.9 0.0 7.9e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 Peptidase C26 Asn_synthase PF00733.21 AIC16588.1 - 3e-06 27.2 0.0 5.2e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase ATP_bind_3 PF01171.20 AIC16588.1 - 1.7e-05 24.7 0.0 3e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 PP-loop family QueC PF06508.13 AIC16588.1 - 7e-05 22.4 0.0 0.0012 18.4 0.0 2.1 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 AIC16588.1 - 0.00043 19.9 0.1 0.0038 16.8 0.0 2.1 2 0 0 2 2 2 1 Thiamine biosynthesis protein (ThiI) tRNA_Me_trans PF03054.16 AIC16588.1 - 0.0028 16.5 0.0 0.01 14.6 0.0 1.8 2 0 0 2 2 2 1 tRNA methyl transferase Mito_fiss_reg PF05308.11 AIC16589.1 - 0.003 17.7 3.0 0.0042 17.2 3.0 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator CCDC53 PF10152.9 AIC16589.1 - 0.011 16.1 1.1 0.017 15.6 1.1 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex YTH PF04146.15 AIC16589.1 - 0.045 13.7 0.0 0.056 13.4 0.0 1.2 1 0 0 1 1 1 0 YT521-B-like domain Glyco_transf_36 PF06165.11 AIC16589.1 - 0.096 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 36 DivIVA PF05103.13 AIC16589.1 - 0.12 12.5 0.7 0.19 11.8 0.1 1.6 2 0 0 2 2 2 0 DivIVA protein Ac110_PIF PF07280.11 AIC16590.1 - 0.0037 17.0 0.0 0.0056 16.4 0.0 1.4 1 0 0 1 1 1 1 Per os infectivity factor AC110 DUF945 PF06097.11 AIC16590.1 - 0.041 13.0 1.4 0.038 13.1 1.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF945) MAF_flag10 PF01973.18 AIC16591.1 - 1.5e-36 125.7 0.1 2e-36 125.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF115 TPK_catalytic PF04263.16 AIC16591.1 - 3e-05 24.0 0.2 8.4e-05 22.6 0.2 1.8 1 1 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain DUF2613 PF11021.8 AIC16593.1 - 0.057 13.5 0.3 0.1 12.7 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2613) CwsA PF10814.8 AIC16593.1 - 0.15 12.2 0.1 0.24 11.6 0.1 1.3 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA DUF945 PF06097.11 AIC16593.1 - 0.24 10.5 0.8 0.48 9.5 0.4 1.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF945) tRNA-synt_1 PF00133.22 AIC16598.1 - 2.1e-110 369.8 0.0 3.9e-109 365.6 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AIC16598.1 - 7.8e-33 113.6 0.1 1.7e-32 112.4 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AIC16598.1 - 7.8e-25 87.4 0.0 6e-14 51.6 0.0 3.4 3 0 0 3 3 3 3 tRNA synthetases class I (M) DZR PF12773.7 AIC16598.1 - 0.00053 20.0 0.8 0.21 11.7 0.4 2.4 2 0 0 2 2 2 1 Double zinc ribbon tRNA-synt_1_2 PF13603.6 AIC16598.1 - 0.0012 18.3 0.1 0.093 12.2 0.0 2.8 2 1 1 3 3 3 1 Leucyl-tRNA synthetase, Domain 2 TF_Zn_Ribbon PF08271.12 AIC16598.1 - 0.008 15.7 1.0 3.2 7.4 0.3 2.7 2 0 0 2 2 2 2 TFIIB zinc-binding zf-TFIIB PF13453.6 AIC16598.1 - 0.02 14.2 2.0 13 5.2 0.0 3.5 3 0 0 3 3 3 0 Transcription factor zinc-finger tRNA-synt_1e PF01406.19 AIC16598.1 - 0.022 14.1 0.0 0.25 10.7 0.0 2.2 2 0 0 2 2 2 0 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AIC16598.1 - 0.03 13.3 0.0 1.1 8.2 0.0 2.7 3 0 0 3 3 3 0 tRNA synthetases class I (K) MqsA_antitoxin PF15731.5 AIC16598.1 - 0.051 13.7 0.1 0.6 10.2 0.0 2.3 2 0 0 2 2 2 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA zf-ACC PF17848.1 AIC16598.1 - 0.53 10.4 3.9 31 4.8 0.3 3.4 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zinc_ribbon_2 PF13240.6 AIC16598.1 - 0.76 9.6 11.0 2.4 8.0 0.2 3.3 3 0 0 3 3 3 0 zinc-ribbon domain Nudix_N_2 PF14803.6 AIC16598.1 - 0.8 9.7 4.0 6.1 6.8 0.0 2.8 2 1 0 2 2 2 0 Nudix N-terminal Zn-ribbon_8 PF09723.10 AIC16598.1 - 2.1 8.5 6.3 17 5.6 0.8 3.3 3 0 0 3 3 3 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 AIC16598.1 - 2.3 7.8 7.8 6.5 6.3 0.1 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 AIC16598.1 - 3.6 7.6 5.8 23 5.0 0.3 3.3 3 0 0 3 3 3 0 Transposase zinc-ribbon domain zf-FPG_IleRS PF06827.14 AIC16598.1 - 6.6 6.7 6.6 9.3 6.2 0.2 3.0 3 0 0 3 3 2 0 Zinc finger found in FPG and IleRS ADH_zinc_N PF00107.26 AIC16599.1 - 4.9e-30 104.2 3.5 9.3e-30 103.3 3.5 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIC16599.1 - 2.7e-23 81.9 4.0 4.6e-23 81.2 4.0 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AIC16599.1 - 1.7e-22 80.9 0.3 2.7e-22 80.2 0.3 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Eno-Rase_NADH_b PF12242.8 AIC16599.1 - 0.072 12.9 1.3 0.22 11.3 1.3 1.8 1 0 0 1 1 1 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase NADH_4Fe-4S PF10589.9 AIC16599.1 - 0.12 12.5 0.9 0.26 11.4 0.9 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region ADH_N_2 PF16884.5 AIC16599.1 - 0.15 12.0 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of oxidoreductase Pterin_bind PF00809.22 AIC16601.1 - 7.3e-50 169.9 0.9 3.4e-49 167.7 0.9 1.8 1 1 0 1 1 1 1 Pterin binding enzyme MR_MLE_C PF13378.6 AIC16601.1 - 0.021 14.4 0.5 0.23 11.0 0.2 2.2 1 1 1 2 2 2 0 Enolase C-terminal domain-like IMPDH PF00478.25 AIC16602.1 - 6.7e-148 492.3 7.9 7.8e-148 492.1 7.9 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 AIC16602.1 - 4.7e-25 87.8 0.5 1.4e-12 47.8 0.1 3.3 4 0 0 4 4 3 2 CBS domain NMO PF03060.15 AIC16602.1 - 3.1e-14 53.1 5.3 1.5e-10 41.0 2.2 2.3 2 1 0 2 2 2 2 Nitronate monooxygenase FMN_dh PF01070.18 AIC16602.1 - 4.9e-08 32.4 13.5 2.3e-07 30.2 13.1 2.3 2 1 0 2 2 2 1 FMN-dependent dehydrogenase His_biosynth PF00977.21 AIC16602.1 - 4.2e-06 26.4 2.2 0.0032 16.9 0.1 2.8 2 1 1 3 3 3 2 Histidine biosynthesis protein PEP_mutase PF13714.6 AIC16602.1 - 0.00033 20.2 1.1 0.037 13.5 0.2 2.4 2 0 0 2 2 2 1 Phosphoenolpyruvate phosphomutase FAD_binding_4 PF01565.23 AIC16602.1 - 0.00064 19.5 0.0 0.054 13.2 0.0 2.8 2 0 0 2 2 2 1 FAD binding domain DHO_dh PF01180.21 AIC16602.1 - 0.0014 17.9 4.7 0.0019 17.5 0.7 2.4 1 1 1 2 2 2 1 Dihydroorotate dehydrogenase Radical_SAM PF04055.21 AIC16602.1 - 0.0025 18.2 0.1 1.1 9.7 0.0 3.0 2 1 1 3 3 3 1 Radical SAM superfamily Glu_synthase PF01645.17 AIC16602.1 - 0.012 14.7 3.5 0.023 13.9 3.5 1.4 1 0 0 1 1 1 0 Conserved region in glutamate synthase PucR PF07905.11 AIC16602.1 - 0.044 14.1 0.1 1.4 9.3 0.0 2.7 2 0 0 2 2 2 0 Purine catabolism regulatory protein-like family ThiG PF05690.14 AIC16602.1 - 0.26 10.6 2.9 0.35 10.2 0.5 2.1 1 1 1 2 2 2 0 Thiazole biosynthesis protein ThiG G3P_antiterm PF04309.12 AIC16602.1 - 0.6 9.5 3.8 2 7.8 0.1 3.4 4 0 0 4 4 4 0 Glycerol-3-phosphate responsive antiterminator EMP24_GP25L PF01105.24 AIC16603.1 - 0.00043 20.3 0.0 0.00055 19.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF1533 PF07550.11 AIC16603.1 - 0.14 12.1 0.1 0.28 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1533) PDT PF00800.18 AIC16605.1 - 2.1e-66 223.2 0.0 2.9e-66 222.8 0.0 1.2 1 0 0 1 1 1 1 Prephenate dehydratase ACT PF01842.25 AIC16605.1 - 9e-10 38.2 0.0 1.7e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 ACT domain CPSase_sm_chain PF00988.22 AIC16605.1 - 0.095 12.5 0.0 0.17 11.7 0.0 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain ECR1_N PF14382.6 AIC16606.1 - 1.4e-05 24.8 0.0 3e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region EXOSC1 PF10447.9 AIC16606.1 - 0.014 16.0 0.2 1.9 9.1 0.1 2.5 1 1 1 2 2 2 0 Exosome component EXOSC1/CSL4 Prok-RING_1 PF14446.6 AIC16606.1 - 0.046 13.7 0.9 0.071 13.1 0.9 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 DNA_RNApol_7kD PF03604.13 AIC16606.1 - 0.58 9.9 2.3 1.5 8.6 2.3 1.6 1 0 0 1 1 1 0 DNA directed RNA polymerase, 7 kDa subunit AAA PF00004.29 AIC16607.1 - 7.8e-100 330.5 0.2 5.4e-51 172.5 0.0 2.7 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) CDC48_N PF02359.18 AIC16607.1 - 1.8e-31 108.1 0.4 5.2e-31 106.7 0.4 1.9 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), N-terminal domain AAA_lid_3 PF17862.1 AIC16607.1 - 1e-23 82.8 0.1 1e-12 47.7 0.0 2.9 2 1 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 AIC16607.1 - 7.6e-18 65.2 0.0 3.7e-08 33.7 0.0 2.4 2 0 0 2 2 2 2 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 AIC16607.1 - 1.8e-15 57.0 0.0 3.3e-09 36.7 0.0 2.8 2 0 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 AIC16607.1 - 1.6e-14 54.7 0.2 2.4e-06 28.0 0.0 3.7 2 2 1 3 3 3 2 AAA ATPase domain TIP49 PF06068.13 AIC16607.1 - 4.9e-11 42.4 0.1 0.00016 21.0 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_22 PF13401.6 AIC16607.1 - 2.1e-10 41.0 1.4 0.002 18.4 0.1 4.3 3 2 0 3 3 2 2 AAA domain AAA_33 PF13671.6 AIC16607.1 - 2.9e-10 40.5 0.0 0.00062 19.9 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 AIC16607.1 - 3e-10 40.2 1.3 0.00018 21.5 0.1 4.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIC16607.1 - 1.2e-09 38.3 0.0 0.00013 22.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain CDC48_2 PF02933.17 AIC16607.1 - 5.1e-09 35.8 0.1 1.3e-08 34.5 0.1 1.8 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 Sigma54_activat PF00158.26 AIC16607.1 - 8.3e-08 32.1 0.3 0.035 13.8 0.0 3.5 3 1 0 3 3 3 2 Sigma-54 interaction domain IstB_IS21 PF01695.17 AIC16607.1 - 8.9e-08 32.1 0.0 0.0073 16.0 0.0 2.3 2 0 0 2 2 2 2 IstB-like ATP binding protein Bac_DnaA PF00308.18 AIC16607.1 - 5.3e-07 29.7 0.0 0.00084 19.2 0.0 2.6 2 0 0 2 2 2 1 Bacterial dnaA protein RNA_helicase PF00910.22 AIC16607.1 - 1.6e-06 28.5 0.0 0.042 14.2 0.0 2.8 2 0 0 2 2 2 2 RNA helicase Mg_chelatase PF01078.21 AIC16607.1 - 1.7e-06 27.6 2.2 0.039 13.3 0.1 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI ATPase PF06745.13 AIC16607.1 - 2.1e-06 27.3 1.9 0.12 11.8 0.0 3.8 3 1 1 4 4 3 2 KaiC AAA_7 PF12775.7 AIC16607.1 - 2.3e-06 27.2 0.1 0.037 13.5 0.0 2.6 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_24 PF13479.6 AIC16607.1 - 4.2e-06 26.6 0.0 0.024 14.4 0.0 2.6 2 0 0 2 2 2 2 AAA domain TsaE PF02367.17 AIC16607.1 - 4.6e-06 26.7 0.0 0.094 12.7 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 AIC16607.1 - 5.7e-06 26.7 0.0 0.029 14.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 AIC16607.1 - 9.2e-06 25.7 0.1 0.18 11.7 0.1 3.6 4 0 0 4 4 3 2 NACHT domain AAA_18 PF13238.6 AIC16607.1 - 1.3e-05 25.8 0.0 0.033 14.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 AIC16607.1 - 1.5e-05 24.3 0.1 0.15 11.3 0.0 2.5 2 0 0 2 2 2 2 Zeta toxin PhoH PF02562.16 AIC16607.1 - 3.7e-05 23.3 0.4 0.29 10.6 0.1 2.4 2 0 0 2 2 2 2 PhoH-like protein DUF815 PF05673.13 AIC16607.1 - 7.7e-05 22.0 0.0 0.052 12.7 0.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATPase_2 PF01637.18 AIC16607.1 - 9e-05 22.5 0.1 0.029 14.3 0.0 3.1 3 1 0 3 3 2 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 AIC16607.1 - 0.0001 22.8 0.0 0.8 10.2 0.0 2.5 2 0 0 2 2 2 2 ABC transporter AAA_25 PF13481.6 AIC16607.1 - 0.00023 20.8 5.3 1.3 8.6 0.2 3.7 2 2 1 3 3 3 1 AAA domain NB-ARC PF00931.22 AIC16607.1 - 0.00033 19.9 0.1 0.43 9.7 0.0 2.4 2 0 0 2 2 2 2 NB-ARC domain Cytidylate_kin PF02224.18 AIC16607.1 - 0.00049 19.9 0.1 0.45 10.2 0.0 2.4 2 0 0 2 2 2 1 Cytidylate kinase AAA_3 PF07726.11 AIC16607.1 - 0.00096 19.0 0.0 0.53 10.1 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF2075 PF09848.9 AIC16607.1 - 0.0015 17.9 0.0 0.38 9.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA_30 PF13604.6 AIC16607.1 - 0.0016 18.2 0.7 1.9 8.2 0.0 2.6 2 0 0 2 2 2 2 AAA domain Parvo_NS1 PF01057.17 AIC16607.1 - 0.0017 17.5 0.1 0.31 10.1 0.0 2.2 2 0 0 2 2 2 1 Parvovirus non-structural protein NS1 TniB PF05621.11 AIC16607.1 - 0.002 17.5 0.0 0.82 9.1 0.0 2.9 3 0 0 3 3 3 1 Bacterial TniB protein AAA_11 PF13086.6 AIC16607.1 - 0.0027 17.5 0.0 0.65 9.7 0.0 2.2 2 0 0 2 2 2 1 AAA domain AFG1_ATPase PF03969.16 AIC16607.1 - 0.0031 16.5 0.1 0.83 8.5 0.0 2.6 3 0 0 3 3 3 1 AFG1-like ATPase Guanylate_kin PF00625.21 AIC16607.1 - 0.009 15.7 0.2 6.9 6.3 0.0 3.4 2 1 1 3 3 3 0 Guanylate kinase AAA_17 PF13207.6 AIC16607.1 - 0.013 15.9 0.0 1.1 9.7 0.0 2.8 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 AIC16607.1 - 0.019 15.1 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain NTPase_1 PF03266.15 AIC16607.1 - 0.021 14.7 0.9 11 5.9 0.0 3.5 2 1 1 3 3 3 0 NTPase PduV-EutP PF10662.9 AIC16607.1 - 0.023 14.4 0.1 12 5.6 0.0 3.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation T2SSE PF00437.20 AIC16607.1 - 0.024 13.7 0.1 6.1 5.8 0.1 2.3 2 0 0 2 2 2 0 Type II/IV secretion system protein ATP-synt_ab PF00006.25 AIC16607.1 - 0.029 14.0 0.0 4.9 6.7 0.0 2.4 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain ResIII PF04851.15 AIC16607.1 - 0.031 14.3 0.0 9.9 6.1 0.0 2.5 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_29 PF13555.6 AIC16607.1 - 0.032 14.0 0.4 5.8 6.7 0.1 2.4 2 0 0 2 2 2 0 P-loop containing region of AAA domain Viral_helicase1 PF01443.18 AIC16607.1 - 0.035 13.8 0.0 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF1905 PF08922.11 AIC16607.1 - 0.036 14.1 0.0 0.095 12.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1905) Vps4_C PF09336.10 AIC16607.1 - 0.042 13.8 0.5 2.3 8.3 0.1 2.8 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain Rad17 PF03215.15 AIC16607.1 - 0.052 13.5 0.1 28 4.5 0.0 3.1 2 1 1 3 3 3 0 Rad17 P-loop domain CPT PF07931.12 AIC16607.1 - 0.06 13.2 0.0 6.3 6.6 0.0 2.5 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein SKI PF01202.22 AIC16607.1 - 0.078 13.1 0.1 8.4 6.5 0.0 2.6 2 0 0 2 2 2 0 Shikimate kinase IPT PF01745.16 AIC16607.1 - 0.11 11.9 0.2 12 5.1 0.0 2.4 2 0 0 2 2 2 0 Isopentenyl transferase AAA_19 PF13245.6 AIC16607.1 - 0.12 12.7 2.8 3.4 8.0 0.1 3.1 2 1 1 3 3 2 0 AAA domain PIF1 PF05970.14 AIC16607.1 - 0.18 10.9 0.0 20 4.2 0.0 2.3 2 0 0 2 2 2 0 PIF1-like helicase Orn_Arg_deC_N PF02784.16 AIC16608.1 - 2.3e-37 128.7 0.0 3e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 AIC16608.1 - 1.4e-09 38.1 0.0 1.6e-09 37.8 0.0 1.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Acylphosphatase PF00708.18 AIC16609.1 - 9.5e-28 96.4 0.1 1.1e-27 96.3 0.1 1.0 1 0 0 1 1 1 1 Acylphosphatase His_biosynth PF00977.21 AIC16611.1 - 1.7e-86 289.4 1.7 2e-86 289.2 1.7 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 AIC16611.1 - 9.8e-09 34.7 0.1 7.2e-05 22.0 0.0 2.1 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 AIC16611.1 - 2.7e-07 30.3 0.7 0.014 14.8 0.1 2.2 2 0 0 2 2 2 2 Nitronate monooxygenase ThiG PF05690.14 AIC16611.1 - 1.3e-05 24.6 0.6 0.024 14.0 0.2 2.1 2 0 0 2 2 2 2 Thiazole biosynthesis protein ThiG TMP-TENI PF02581.17 AIC16611.1 - 0.00022 20.6 0.2 0.61 9.4 0.0 2.3 2 0 0 2 2 2 2 Thiamine monophosphate synthase DHO_dh PF01180.21 AIC16611.1 - 0.00098 18.4 0.1 0.11 11.7 0.1 2.1 2 0 0 2 2 2 2 Dihydroorotate dehydrogenase G3P_antiterm PF04309.12 AIC16611.1 - 0.0013 18.2 0.2 0.056 12.9 0.1 2.2 2 0 0 2 2 2 1 Glycerol-3-phosphate responsive antiterminator PcrB PF01884.17 AIC16611.1 - 0.002 17.6 0.4 0.046 13.2 0.1 2.2 2 0 0 2 2 2 1 PcrB family Trp_syntA PF00290.20 AIC16611.1 - 0.012 14.5 0.1 0.021 13.7 0.1 1.3 1 0 0 1 1 1 0 Tryptophan synthase alpha chain His_biosynth PF00977.21 AIC16612.1 - 7.9e-67 225.1 5.4 8.9e-67 224.9 5.4 1.0 1 0 0 1 1 1 1 Histidine biosynthesis protein PcrB PF01884.17 AIC16612.1 - 1.1e-09 38.2 2.2 6.4e-05 22.5 0.2 2.2 2 0 0 2 2 2 2 PcrB family Dus PF01207.17 AIC16612.1 - 8.7e-08 31.6 0.9 3.8e-05 22.9 0.1 2.2 2 0 0 2 2 2 2 Dihydrouridine synthase (Dus) DHO_dh PF01180.21 AIC16612.1 - 3.1e-05 23.3 1.8 0.00081 18.7 0.4 2.1 2 0 0 2 2 2 1 Dihydroorotate dehydrogenase IGPS PF00218.21 AIC16612.1 - 0.00014 21.1 0.1 0.28 10.3 0.0 2.3 2 0 0 2 2 2 2 Indole-3-glycerol phosphate synthase ThiG PF05690.14 AIC16612.1 - 0.0022 17.4 5.9 0.0042 16.4 1.0 2.4 2 1 0 2 2 2 1 Thiazole biosynthesis protein ThiG CutC PF03932.14 AIC16612.1 - 0.0046 16.4 0.4 2.5 7.5 0.0 3.0 2 1 1 3 3 3 1 CutC family NanE PF04131.14 AIC16612.1 - 0.0087 15.3 3.0 1.3 8.2 0.3 2.3 1 1 1 2 2 2 2 Putative N-acetylmannosamine-6-phosphate epimerase FMN_dh PF01070.18 AIC16612.1 - 0.014 14.5 2.6 0.15 11.0 0.3 2.1 2 0 0 2 2 2 0 FMN-dependent dehydrogenase DUF4406 PF14359.6 AIC16612.1 - 0.026 15.0 0.1 0.071 13.6 0.1 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4406) Trp_syntA PF00290.20 AIC16612.1 - 0.046 12.6 0.3 0.046 12.6 0.3 2.3 3 0 0 3 3 3 0 Tryptophan synthase alpha chain Ala_racemase_N PF01168.20 AIC16612.1 - 0.053 13.2 0.2 0.076 12.6 0.2 1.2 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain F420_oxidored PF03807.17 AIC16612.1 - 0.061 13.9 1.7 1.5 9.5 1.7 2.9 1 1 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent GATase PF00117.28 AIC16613.1 - 1.6e-23 83.5 0.0 1.8e-23 83.3 0.0 1.0 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 AIC16613.1 - 2e-09 37.3 0.0 2.3e-09 37.1 0.0 1.2 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain Peptidase_C26 PF07722.13 AIC16613.1 - 3.6e-09 36.7 0.0 1.1e-07 31.8 0.0 2.2 1 1 0 1 1 1 1 Peptidase C26 SNO PF01174.19 AIC16613.1 - 1.9e-06 27.9 0.0 2.2e-05 24.4 0.0 2.0 1 1 0 1 1 1 1 SNO glutamine amidotransferase family DJ-1_PfpI PF01965.24 AIC16613.1 - 0.0093 15.8 0.0 0.033 14.0 0.0 1.8 2 0 0 2 2 2 1 DJ-1/PfpI family ThuA PF06283.11 AIC16613.1 - 0.049 13.8 0.0 0.063 13.5 0.0 1.1 1 0 0 1 1 1 0 Trehalose utilisation 3-HAO PF06052.12 AIC16613.1 - 0.059 13.0 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase IGPD PF00475.18 AIC16614.1 - 1.8e-43 148.3 1.4 1.8e-43 148.3 1.4 1.3 2 0 0 2 2 2 1 Imidazoleglycerol-phosphate dehydratase HAD_2 PF13419.6 AIC16615.1 - 2.6e-11 43.9 0.2 1.7e-06 28.2 0.0 2.2 1 1 1 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIC16615.1 - 2.3e-08 34.6 0.6 4.9e-07 30.2 0.6 2.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIC16615.1 - 0.0032 17.5 0.0 0.006 16.6 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like PNK3P PF08645.11 AIC16615.1 - 0.008 15.9 0.2 1.7 8.3 0.0 2.4 2 0 0 2 2 2 2 Polynucleotide kinase 3 phosphatase Aminotran_1_2 PF00155.21 AIC16616.1 - 8.6e-43 146.9 0.0 9.9e-43 146.7 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 AIC16616.1 - 9.9e-08 31.2 0.0 1.6e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Allinase Aminotran_5 PF00266.19 AIC16616.1 - 0.011 14.7 0.0 0.085 11.8 0.0 1.9 2 0 0 2 2 2 0 Aminotransferase class-V DUF3294 PF07957.11 AIC16616.1 - 0.11 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) Histidinol_dh PF00815.20 AIC16617.1 - 5.2e-137 457.2 8.2 6.4e-137 456.9 8.2 1.0 1 0 0 1 1 1 1 Histidinol dehydrogenase FlbD PF06289.11 AIC16617.1 - 0.075 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Flagellar and Swarming motility proteins HisG PF01634.18 AIC16618.1 - 3.2e-43 147.5 0.1 4.2e-43 147.1 0.1 1.2 1 0 0 1 1 1 1 ATP phosphoribosyltransferase HisG_C PF08029.11 AIC16618.1 - 3.9e-16 59.0 0.0 1.2e-15 57.4 0.0 1.8 2 0 0 2 2 2 1 HisG, C-terminal domain HMG-CoA_red PF00368.18 AIC16619.1 - 2.3e-105 352.6 13.2 2.8e-105 352.4 13.2 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase Chlorosome_CsmC PF11098.8 AIC16619.1 - 0.0089 16.0 2.1 0.017 15.1 0.0 2.5 3 1 1 4 4 4 1 Chlorosome envelope protein C C1_1 PF00130.22 AIC16621.1 - 0.0034 17.2 5.8 0.0049 16.7 5.8 1.2 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 AIC16621.1 - 0.013 15.4 6.6 0.021 14.7 6.6 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 IBR PF01485.21 AIC16621.1 - 0.3 11.3 11.6 1.3 9.3 11.6 1.8 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain DZR PF12773.7 AIC16621.1 - 0.78 9.8 7.9 2.6 8.1 7.9 1.8 1 1 0 1 1 1 0 Double zinc ribbon Cupredoxin_1 PF13473.6 AIC16622.1 - 7.4e-12 45.3 0.2 1.2e-11 44.6 0.2 1.3 1 1 0 1 1 1 1 Cupredoxin-like domain Copper-bind PF00127.20 AIC16622.1 - 1.5e-09 38.2 0.1 2.5e-09 37.5 0.1 1.3 1 1 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family GSDH PF07995.11 AIC16623.1 - 2e-88 296.9 0.0 3.7e-88 296.0 0.0 1.4 1 1 0 1 1 1 1 Glucose / Sorbosone dehydrogenase Reg_prop PF07494.11 AIC16623.1 - 0.0028 17.7 0.4 7.7 7.1 0.0 4.2 4 0 0 4 4 4 1 Two component regulator propeller DUF5122 PF17164.4 AIC16623.1 - 0.0032 17.7 0.1 0.021 15.1 0.0 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF5122) beta-propeller SGL PF08450.12 AIC16623.1 - 0.0089 15.6 0.0 0.11 12.1 0.0 2.4 2 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region CBS PF00571.28 AIC16624.1 - 1.7e-31 108.4 5.7 1e-09 38.7 0.5 4.3 4 0 0 4 4 4 4 CBS domain Ribosomal_S30AE PF02482.19 AIC16624.1 - 5.4e-05 23.9 1.2 0.00014 22.6 1.2 1.7 1 0 0 1 1 1 1 Sigma 54 modulation protein / S30EA ribosomal protein DUF2228 PF10228.9 AIC16624.1 - 0.072 12.8 2.5 0.18 11.5 0.5 2.0 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) OTT_1508_deam PF14441.6 AIC16625.1 - 0.026 14.5 0.1 0.029 14.4 0.1 1.3 1 1 0 1 1 1 0 OTT_1508-like deaminase DUF629 PF04780.12 AIC16625.1 - 0.073 11.6 0.0 0.073 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) Ribosomal_S14 PF00253.21 AIC16626.1 - 0.038 13.8 0.2 0.054 13.3 0.2 1.2 1 0 0 1 1 1 0 Ribosomal protein S14p/S29e zf-UBR PF02207.20 AIC16626.1 - 0.29 11.3 4.7 9.8 6.4 1.8 2.1 1 1 1 2 2 2 0 Putative zinc finger in N-recognin (UBR box) eIF-1a PF01176.19 AIC16627.1 - 1e-20 73.3 0.8 1.2e-20 73.0 0.8 1.1 1 0 0 1 1 1 1 Translation initiation factor 1A / IF-1 Myosin_N PF02736.19 AIC16627.1 - 0.00058 19.6 1.7 0.0032 17.3 0.7 2.1 2 0 0 2 2 2 1 Myosin N-terminal SH3-like domain RsgA_N PF16745.5 AIC16627.1 - 0.0024 17.6 0.5 0.0038 16.9 0.5 1.4 1 0 0 1 1 1 1 RsgA N-terminal domain Prot_ATP_ID_OB PF16450.5 AIC16627.1 - 0.024 14.6 0.1 0.036 14.0 0.1 1.1 1 0 0 1 1 1 0 Proteasomal ATPase OB C-terminal domain BcsB PF03170.13 AIC16629.1 - 0.045 12.1 0.4 0.073 11.4 0.1 1.3 1 1 0 1 1 1 0 Bacterial cellulose synthase subunit DUF929 PF06053.11 AIC16629.1 - 0.13 11.6 2.9 0.17 11.2 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) NdhO PF11910.8 AIC16630.1 - 0.0052 16.9 0.0 0.0052 16.9 0.0 1.1 1 0 0 1 1 1 1 Cyanobacterial and plant NDH-1 subunit O Putative_PNPOx PF01243.20 AIC16631.1 - 1.1e-14 54.4 0.0 1.5e-14 54.0 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIC16631.1 - 1.7e-07 31.3 0.0 1.9e-07 31.2 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIC16631.1 - 0.0021 17.7 0.1 0.0092 15.6 0.1 1.8 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Bac_luciferase PF00296.20 AIC16632.1 - 3e-51 174.7 0.0 3.8e-51 174.4 0.0 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase Methyltransf_2 PF00891.18 AIC16633.1 - 3e-52 177.0 0.0 3.9e-52 176.6 0.0 1.1 1 0 0 1 1 1 1 O-methyltransferase domain Dimerisation2 PF16864.5 AIC16633.1 - 3.7e-11 42.8 0.0 1.3e-10 41.1 0.0 1.8 2 0 0 2 2 2 1 Dimerisation domain HTH_IclR PF09339.10 AIC16633.1 - 0.0016 18.2 0.0 0.0036 17.1 0.0 1.6 1 0 0 1 1 1 1 IclR helix-turn-helix domain Methyltransf_23 PF13489.6 AIC16633.1 - 0.0036 17.2 0.0 0.011 15.5 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain TrmB PF01978.19 AIC16633.1 - 0.011 15.6 0.0 0.029 14.2 0.0 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Methyltransf_12 PF08242.12 AIC16633.1 - 0.012 16.4 0.0 0.021 15.5 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain HTH_20 PF12840.7 AIC16633.1 - 0.024 14.7 0.0 0.064 13.3 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_45 PF14947.6 AIC16633.1 - 0.052 13.5 0.0 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix Methyltransf_25 PF13649.6 AIC16633.1 - 0.053 14.2 0.0 0.1 13.3 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain Ribosomal_S14 PF00253.21 AIC16633.1 - 0.057 13.2 0.0 11 5.8 0.0 2.8 3 0 0 3 3 3 0 Ribosomal protein S14p/S29e MTS PF05175.14 AIC16633.1 - 0.073 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain Methyltransf_20 PF12147.8 AIC16633.1 - 0.13 11.4 0.0 0.25 10.5 0.0 1.4 1 1 0 1 1 1 0 Putative methyltransferase MarR_2 PF12802.7 AIC16633.1 - 0.14 12.0 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 MarR family PG_binding_1 PF01471.18 AIC16636.1 - 4.4e-62 206.1 3.9 6.1e-18 64.8 0.0 4.6 5 0 0 5 5 5 4 Putative peptidoglycan binding domain PG_binding_3 PF09374.10 AIC16636.1 - 9.8e-25 86.6 2.4 0.00056 20.1 0.0 7.6 5 3 3 8 8 8 7 Predicted Peptidoglycan domain DUF1794 PF08768.11 AIC16636.1 - 0.0097 15.9 0.0 15 5.5 0.0 3.2 1 1 2 3 3 3 2 Domain of unknown function (DUF1794) Exo_endo_phos PF03372.23 AIC16637.1 - 4.5e-11 42.7 0.1 6.1e-11 42.3 0.1 1.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Swi3 PF07962.12 AIC16637.1 - 0.0072 16.3 0.1 0.03 14.3 0.0 2.0 2 0 0 2 2 2 1 Replication Fork Protection Component Swi3 YesK PF14150.6 AIC16638.1 - 0.0067 16.6 5.2 0.0067 16.6 5.2 2.3 2 1 0 2 2 2 1 YesK-like protein DUF2070 PF09843.9 AIC16638.1 - 0.066 11.5 6.5 0.071 11.4 6.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) EMP70 PF02990.16 AIC16638.1 - 0.07 11.8 4.8 0.087 11.5 4.8 1.0 1 0 0 1 1 1 0 Endomembrane protein 70 DUF1129 PF06570.11 AIC16638.1 - 0.18 11.2 3.1 0.19 11.2 3.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) SdpI PF13630.6 AIC16638.1 - 0.26 11.4 8.7 0.49 10.6 0.6 2.2 2 0 0 2 2 2 0 SdpI/YhfL protein family Tetraspanin PF00335.20 AIC16638.1 - 1.8 8.2 5.0 2.1 8.0 5.0 1.1 1 0 0 1 1 1 0 Tetraspanin family FeoA PF04023.14 AIC16639.1 - 0.072 13.4 0.0 0.095 13.0 0.0 1.3 1 0 0 1 1 1 0 FeoA domain Fer4_7 PF12838.7 AIC16642.1 - 1.9e-09 37.9 2.5 0.0002 21.9 0.6 2.3 2 0 0 2 2 2 2 4Fe-4S dicluster domain Fer4 PF00037.27 AIC16642.1 - 4.3e-09 35.8 12.2 5.5e-06 26.0 1.6 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_10 PF13237.6 AIC16642.1 - 3.9e-08 33.3 16.2 1.7e-07 31.2 5.8 1.7 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_16 PF13484.6 AIC16642.1 - 8e-07 29.9 16.3 5.4e-05 24.1 7.8 2.1 1 1 1 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 AIC16642.1 - 1.3e-06 28.4 7.4 1.5e-05 25.0 8.2 2.0 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_8 PF13183.6 AIC16642.1 - 3.8e-06 27.2 5.6 0.0014 19.1 8.6 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain Fer4_6 PF12837.7 AIC16642.1 - 1.6e-05 24.8 12.6 0.011 15.7 1.6 2.3 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_13 PF13370.6 AIC16642.1 - 3.1e-05 24.4 4.9 0.066 13.8 0.1 2.7 2 0 0 2 2 2 2 4Fe-4S single cluster domain of Ferredoxin I Fer4_21 PF14697.6 AIC16642.1 - 4e-05 23.7 9.4 0.0084 16.2 9.5 2.3 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_17 PF13534.6 AIC16642.1 - 0.00012 22.6 4.7 0.0019 18.7 5.9 2.1 1 1 1 2 2 2 2 4Fe-4S dicluster domain Fer4_2 PF12797.7 AIC16642.1 - 0.00038 20.4 10.7 0.039 14.0 3.2 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_4 PF12800.7 AIC16642.1 - 0.00042 20.6 6.1 0.036 14.6 1.3 2.4 2 0 0 2 2 2 2 4Fe-4S binding domain Fer4_15 PF13459.6 AIC16642.1 - 0.0089 16.7 7.7 0.24 12.2 2.5 2.5 2 1 0 2 2 2 2 4Fe-4S single cluster domain Fer4_22 PF17179.4 AIC16642.1 - 0.01 16.6 0.5 5.8 7.8 0.1 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_18 PF13746.6 AIC16642.1 - 0.01 16.0 8.6 0.031 14.5 6.5 2.1 1 1 1 2 2 2 0 4Fe-4S dicluster domain Fer4_3 PF12798.7 AIC16642.1 - 0.072 14.1 14.9 1.7 9.7 6.4 2.4 2 0 0 2 2 2 0 4Fe-4S binding domain Rubredoxin_2 PF18073.1 AIC16643.1 - 0.1 12.3 1.1 0.16 11.7 1.1 1.3 1 0 0 1 1 1 0 Rubredoxin metal binding domain ArsA_ATPase PF02374.15 AIC16644.1 - 1.5e-68 231.2 0.0 1.8e-68 231.0 0.0 1.0 1 0 0 1 1 1 1 Anion-transporting ATPase CbiA PF01656.23 AIC16644.1 - 1.4e-08 34.8 0.0 1.8e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 AIC16644.1 - 4.1e-07 30.1 0.0 1.5e-06 28.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain ArsA_HSP20 PF17886.1 AIC16644.1 - 3.5e-05 23.3 0.0 7.3e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 HSP20-like domain found in ArsA ParA PF10609.9 AIC16644.1 - 4e-05 23.2 0.1 0.00078 19.0 0.0 2.3 2 0 0 2 2 2 1 NUBPL iron-transfer P-loop NTPase Fer4_NifH PF00142.18 AIC16644.1 - 0.00023 20.7 0.0 0.00039 20.0 0.0 1.4 1 0 0 1 1 1 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family PhoH PF02562.16 AIC16644.1 - 0.022 14.2 0.0 0.034 13.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein MeaB PF03308.16 AIC16644.1 - 0.022 13.7 0.0 0.049 12.6 0.0 1.5 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB IstB_IS21 PF01695.17 AIC16644.1 - 0.071 12.8 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein CBP_BcsQ PF06564.12 AIC16644.1 - 0.098 12.1 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Ammonium_transp PF00909.21 AIC16645.1 - 1.3e-110 369.9 29.9 1.4e-110 369.7 29.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Arg_repressor_C PF02863.18 AIC16645.1 - 0.11 12.4 0.4 0.37 10.7 0.1 2.1 2 0 0 2 2 2 0 Arginine repressor, C-terminal domain DegT_DnrJ_EryC1 PF01041.17 AIC16646.1 - 1.4e-121 406.2 0.3 1.6e-121 406.0 0.3 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_1_2 PF00155.21 AIC16646.1 - 9.8e-08 31.5 0.0 1.8e-07 30.7 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 AIC16646.1 - 2.8e-05 22.8 0.0 4.2e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 AIC16646.1 - 0.00021 20.4 0.4 0.00037 19.6 0.1 1.5 2 0 0 2 2 2 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AIC16646.1 - 0.00035 20.0 1.9 0.00087 18.6 1.7 1.6 1 1 0 1 1 1 1 Beta-eliminating lyase OKR_DC_1 PF01276.20 AIC16646.1 - 0.0012 17.6 0.0 0.0016 17.2 0.0 1.2 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, major domain ComK PF06338.11 AIC16646.1 - 0.0018 18.0 0.0 0.0032 17.1 0.0 1.4 1 0 0 1 1 1 1 ComK protein UDPG_MGDP_dh PF00984.19 AIC16647.1 - 1.7e-20 73.0 0.0 2.8e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 AIC16647.1 - 6e-09 35.8 0.0 0.0011 18.6 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 AIC16647.1 - 0.0002 21.5 0.0 0.0004 20.6 0.0 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 AIC16647.1 - 0.00024 21.1 0.5 0.00046 20.1 0.1 1.7 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIC16647.1 - 0.0017 17.7 0.1 0.0026 17.1 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPMT PF05724.11 AIC16647.1 - 0.051 13.2 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) NAD_binding_7 PF13241.6 AIC16647.1 - 0.1 13.1 0.0 0.26 11.7 0.0 1.7 2 0 0 2 2 2 0 Putative NAD(P)-binding Polysacc_deac_1 PF01522.21 AIC16648.1 - 3.9e-13 49.4 0.0 5.6e-13 48.9 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide deacetylase SCVP PF17619.2 AIC16648.1 - 0.041 14.8 0.0 0.088 13.7 0.0 1.5 1 0 0 1 1 1 0 Secreted clade V proteins DUF5470 PF17564.2 AIC16648.1 - 0.26 11.5 1.6 0.44 10.8 0.9 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5470) Glycos_transf_2 PF00535.26 AIC16649.1 - 8.6e-32 110.3 0.1 1.3e-31 109.7 0.1 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIC16649.1 - 1.5e-23 83.9 0.5 2.1e-22 80.2 0.5 2.0 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AIC16649.1 - 1.6e-17 63.3 0.0 1.6e-17 63.3 0.0 1.6 2 0 0 2 2 2 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AIC16649.1 - 3.5e-13 49.9 5.8 3.5e-13 49.9 5.8 2.6 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIC16649.1 - 1.6e-07 30.9 0.3 4.1e-05 23.1 0.0 2.2 1 1 1 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIC16649.1 - 2.9e-05 23.7 0.3 4.5e-05 23.1 0.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIC16649.1 - 0.0014 19.1 0.0 0.0034 17.9 0.0 1.7 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_5 PF13712.6 AIC16649.1 - 0.029 14.0 0.0 0.057 13.1 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase like family HXXEE PF13787.6 AIC16649.1 - 0.033 15.0 6.2 0.089 13.6 1.2 2.5 2 0 0 2 2 2 0 Protein of unknown function with HXXEE motif Fringe PF02434.16 AIC16649.1 - 0.089 12.2 0.2 0.67 9.3 0.0 2.0 2 0 0 2 2 2 0 Fringe-like TraP PF07296.11 AIC16649.1 - 0.37 10.0 3.2 0.62 9.2 0.8 2.1 2 0 0 2 2 2 0 TraP protein zf-C2H2_2 PF12756.7 AIC16650.1 - 0.08 13.3 0.1 0.091 13.1 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) UDPG_MGDP_dh PF00984.19 AIC16651.1 - 1.2e-18 67.1 0.0 2.2e-18 66.3 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_N PF03721.14 AIC16651.1 - 2.1e-09 37.2 0.0 0.00033 20.3 0.0 2.2 1 1 1 2 2 2 2 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 AIC16651.1 - 8.3e-05 22.8 0.2 0.00017 21.8 0.0 1.6 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 AIC16651.1 - 0.00067 19.6 0.1 0.00067 19.6 0.1 1.9 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 AIC16651.1 - 0.0037 16.7 0.5 0.0063 15.9 0.0 1.6 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain TPMT PF05724.11 AIC16651.1 - 0.012 15.3 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 Thiopurine S-methyltransferase (TPMT) Beta_propel PF09826.9 AIC16651.1 - 0.068 12.0 0.0 0.079 11.8 0.0 1.1 1 0 0 1 1 1 0 Beta propeller domain Mur_ligase PF01225.25 AIC16651.1 - 0.12 12.7 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, catalytic domain Polysacc_deac_1 PF01522.21 AIC16652.1 - 8.1e-12 45.1 0.0 1.3e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide deacetylase DUF724 PF05266.14 AIC16652.1 - 0.019 14.8 0.0 0.027 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Ribosomal_S8 PF00410.19 AIC16652.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S8 Glycos_transf_2 PF00535.26 AIC16653.1 - 5.9e-35 120.6 0.2 9.2e-35 120.0 0.2 1.3 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 AIC16653.1 - 5.7e-23 82.0 0.3 3.5e-19 69.6 0.0 2.1 2 0 0 2 2 2 2 Glycosyltransferase like family 2 Chitin_synth_2 PF03142.15 AIC16653.1 - 3.8e-14 52.2 5.7 3e-13 49.3 5.7 2.1 1 1 0 1 1 1 1 Chitin synthase Glyco_trans_2_3 PF13632.6 AIC16653.1 - 1.7e-10 41.1 7.5 1.7e-10 41.1 7.5 2.8 2 1 0 2 2 2 1 Glycosyl transferase family group 2 Glyco_transf_21 PF13506.6 AIC16653.1 - 6.7e-07 28.9 0.1 0.0001 21.8 0.0 2.3 2 0 0 2 2 2 2 Glycosyl transferase family 21 Glyco_tranf_2_2 PF10111.9 AIC16653.1 - 1.9e-06 27.5 0.1 3.3e-06 26.8 0.1 1.4 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 AIC16653.1 - 0.0018 18.7 0.0 0.0056 17.2 0.0 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 CofC PF01983.16 AIC16653.1 - 0.11 11.7 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 Guanylyl transferase CofC like DUF2582 PF10771.9 AIC16654.1 - 0.1 12.7 0.0 0.36 11.0 0.0 1.8 2 0 0 2 2 2 0 Winged helix-turn-helix domain (DUF2582) Fil_haemagg PF05594.14 AIC16656.1 - 0.21 12.1 16.0 4.1 8.0 16.0 2.1 1 1 0 1 1 1 0 Haemagluttinin repeat eIF-5_eIF-2B PF01873.17 AIC16657.1 - 3.1e-30 104.4 0.0 4e-30 104.1 0.0 1.1 1 0 0 1 1 1 1 Domain found in IF2B/IF5 TF_Zn_Ribbon PF08271.12 AIC16657.1 - 1.7e-05 24.3 0.6 2.7e-05 23.6 0.6 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding Lar_restr_allev PF14354.6 AIC16657.1 - 0.0014 19.0 0.4 0.002 18.5 0.4 1.3 1 0 0 1 1 1 1 Restriction alleviation protein Lar DpnI PF06044.12 AIC16657.1 - 0.022 14.4 0.0 0.036 13.7 0.0 1.3 1 0 0 1 1 1 0 Dam-replacing family Elf1 PF05129.13 AIC16657.1 - 0.026 14.6 0.1 0.035 14.1 0.1 1.3 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like zf-RRN7 PF11781.8 AIC16657.1 - 0.064 13.0 0.7 7.8 6.3 0.0 2.2 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 DNA_ligase_ZBD PF03119.16 AIC16657.1 - 0.065 13.3 1.2 0.1 12.6 0.5 1.7 1 1 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain Vps36-NZF-N PF16988.5 AIC16657.1 - 0.072 12.5 0.4 0.13 11.6 0.4 1.4 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zinc_ribbon_2 PF13240.6 AIC16657.1 - 0.081 12.7 1.2 5.4 6.9 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIC16657.1 - 0.11 12.6 0.1 3.2 8.0 0.0 2.2 2 0 0 2 2 2 0 Zinc ribbon domain zf-ribbon_3 PF13248.6 AIC16657.1 - 0.12 11.8 0.8 2.8 7.5 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain Prim_Zn_Ribbon PF08273.12 AIC16657.1 - 0.14 12.5 2.8 0.17 12.2 1.5 1.8 2 1 0 2 2 2 0 Zinc-binding domain of primase-helicase Cys_rich_KTR PF14205.6 AIC16657.1 - 0.36 10.7 2.3 0.83 9.5 0.2 2.3 2 1 1 3 3 3 0 Cysteine-rich KTR Prok-RING_1 PF14446.6 AIC16657.1 - 0.42 10.6 4.4 0.37 10.7 0.5 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 zf-C2H2_2 PF12756.7 AIC16658.1 - 0.023 15.0 0.1 0.03 14.6 0.1 1.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zinc_ribbon_12 PF11331.8 AIC16658.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Probable zinc-ribbon domain Tom5 PF10642.9 AIC16659.1 - 0.00079 19.4 1.3 0.0017 18.3 0.0 2.3 2 0 0 2 2 2 1 Mitochondrial import receptor subunit or translocase SecA_SW PF07516.13 AIC16659.1 - 0.0034 17.5 0.4 0.011 15.8 0.0 1.8 1 1 1 2 2 2 1 SecA Wing and Scaffold domain Thioredoxin PF00085.20 AIC16661.1 - 9.6e-29 99.4 0.0 1.4e-28 98.9 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AIC16661.1 - 1.8e-06 28.4 0.1 1.1e-05 25.8 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AIC16661.1 - 1.8e-05 25.0 0.0 0.001 19.3 0.0 2.3 1 1 1 2 2 2 1 Thioredoxin-like OST3_OST6 PF04756.13 AIC16661.1 - 2.4e-05 23.8 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family TraF PF13728.6 AIC16661.1 - 4.8e-05 23.3 0.3 9.4e-05 22.3 0.1 1.5 1 1 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 AIC16661.1 - 0.00076 19.3 0.0 0.001 18.8 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Redoxin PF08534.10 AIC16661.1 - 0.0055 16.4 0.1 0.017 14.9 0.1 1.7 1 1 1 2 2 2 1 Redoxin HyaE PF07449.11 AIC16661.1 - 0.02 14.8 0.0 0.043 13.8 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Thioredoxin_7 PF13899.6 AIC16661.1 - 0.05 13.8 0.0 0.095 12.9 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like Thioredoxin_3 PF13192.6 AIC16661.1 - 0.052 13.6 0.2 0.1 12.6 0.0 1.6 2 0 0 2 2 2 0 Thioredoxin domain Glutaredoxin PF00462.24 AIC16661.1 - 0.054 13.7 0.0 0.13 12.5 0.0 1.7 1 0 0 1 1 1 0 Glutaredoxin AhpC-TSA PF00578.21 AIC16661.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_5 PF13743.6 AIC16661.1 - 0.17 11.5 0.6 16 5.1 0.0 2.8 2 1 1 3 3 3 0 Thioredoxin Thioredoxin_6 PF13848.6 AIC16661.1 - 0.24 11.3 0.0 0.46 10.4 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain GrpE PF01025.19 AIC16662.1 - 1.5e-40 138.6 1.7 1.8e-40 138.3 1.7 1.0 1 0 0 1 1 1 1 GrpE Jnk-SapK_ap_N PF09744.9 AIC16662.1 - 0.018 15.3 4.7 0.024 14.8 4.7 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Atg14 PF10186.9 AIC16662.1 - 0.1 11.7 1.5 0.12 11.4 1.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF730 PF05325.11 AIC16662.1 - 0.27 11.2 1.3 0.45 10.6 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF730) BORCS7 PF16088.5 AIC16662.1 - 0.43 10.9 2.3 2.5 8.4 0.3 2.6 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 DUF883 PF05957.13 AIC16662.1 - 2.6 8.7 6.4 1.6 9.4 0.4 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) HSP70 PF00012.20 AIC16663.1 - 9.1e-214 711.1 16.8 6.7e-195 648.8 11.6 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 AIC16663.1 - 1.1e-16 60.6 4.7 3.2e-16 59.1 4.7 1.8 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 AIC16663.1 - 1.5e-06 28.0 0.1 3.3e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Iron_permease PF04120.12 AIC16663.1 - 0.047 13.5 1.1 8.7 6.1 0.1 3.2 3 0 0 3 3 3 0 Low affinity iron permease GARP PF16731.5 AIC16663.1 - 0.073 12.8 17.7 0.15 11.8 0.0 3.2 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF2278 PF10042.9 AIC16663.1 - 0.19 11.8 0.8 0.4 10.7 0.8 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) DNA_pack_N PF02500.15 AIC16663.1 - 0.29 10.9 1.9 0.5 10.1 1.9 1.3 1 0 0 1 1 1 0 Probable DNA packing protein, N-terminus DnaJ_C PF01556.18 AIC16664.1 - 1.1e-36 126.1 0.0 1.5e-36 125.7 0.0 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 AIC16664.1 - 4e-28 97.3 3.7 6.4e-28 96.7 3.7 1.3 1 0 0 1 1 1 1 DnaJ domain DnaJ_CXXCXGXG PF00684.19 AIC16664.1 - 1.6e-12 47.6 14.8 2.8e-12 46.8 14.8 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AIC16664.1 - 0.0053 16.7 11.3 0.11 12.4 0.9 3.1 2 1 1 3 3 3 3 Tryptophan RNA-binding attenuator protein inhibitory protein zf-RING_10 PF16685.5 AIC16664.1 - 0.69 10.1 3.1 1.7 8.8 3.1 1.7 1 1 0 1 1 1 0 zinc RING finger of MSL2 ArsA_HSP20 PF17886.1 AIC16665.1 - 1.5e-10 40.5 0.1 2.4e-10 39.8 0.1 1.3 1 0 0 1 1 1 1 HSP20-like domain found in ArsA HSP20 PF00011.21 AIC16665.1 - 2.6e-09 37.1 0.5 0.00014 22.0 0.1 2.3 1 1 1 2 2 2 2 Hsp20/alpha crystallin family GvpH PF05455.11 AIC16665.1 - 0.002 18.2 0.8 0.0028 17.7 0.2 1.4 2 0 0 2 2 2 1 GvpH CS PF04969.16 AIC16665.1 - 0.023 15.7 0.0 0.037 15.1 0.0 1.3 1 0 0 1 1 1 0 CS domain Cas_Cas1 PF01867.16 AIC16666.1 - 2.9e-09 36.5 0.0 3.4e-09 36.3 0.0 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas1 GNT-I PF03071.15 AIC16669.1 - 0.11 11.2 0.0 0.11 11.2 0.0 1.0 1 0 0 1 1 1 0 GNT-I family Bac_luciferase PF00296.20 AIC16670.1 - 1.4e-46 159.4 0.1 2e-46 158.9 0.1 1.1 1 0 0 1 1 1 1 Luciferase-like monooxygenase AmoC PF04896.12 AIC16671.1 - 2.2e-12 46.8 4.5 2.7e-12 46.5 4.5 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C DUF2975 PF11188.8 AIC16671.1 - 0.032 14.1 7.4 0.75 9.7 7.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) Zn_peptidase PF04228.13 AIC16672.1 - 1.2e-114 382.7 0.0 1.3e-114 382.6 0.0 1.0 1 0 0 1 1 1 1 Putative neutral zinc metallopeptidase zf-C2H2_4 PF13894.6 AIC16676.1 - 0.0031 18.2 0.4 0.0058 17.4 0.4 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC16676.1 - 0.0035 17.7 0.6 0.0061 17.0 0.6 1.4 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 AIC16676.1 - 0.0081 16.1 0.1 0.012 15.6 0.1 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger Gram_pos_anchor PF00746.21 AIC16676.1 - 0.048 13.6 3.6 0.092 12.7 3.6 1.5 1 0 0 1 1 1 0 LPXTG cell wall anchor motif zinc_ribbon_10 PF10058.9 AIC16678.1 - 0.009 15.7 2.0 0.017 14.8 2.0 1.5 1 1 0 1 1 1 1 Predicted integral membrane zinc-ribbon metal-binding protein DUF1272 PF06906.11 AIC16678.1 - 0.011 15.8 3.2 0.015 15.4 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) Zn_Tnp_IS1 PF03811.13 AIC16678.1 - 1.1 9.1 0.1 1.1 9.1 0.1 2.9 3 1 0 3 3 3 0 InsA N-terminal domain ComA PF02679.15 AIC16679.1 - 1.9e-59 201.1 0.2 4.8e-59 199.8 0.1 1.6 2 0 0 2 2 2 1 (2R)-phospho-3-sulfolactate synthase (ComA) MarR_2 PF12802.7 AIC16679.1 - 0.00019 21.3 0.0 0.00039 20.2 0.0 1.5 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIC16679.1 - 0.00046 20.0 0.0 0.0011 18.9 0.0 1.6 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_43 PF09904.9 AIC16679.1 - 0.0083 16.0 0.1 0.037 14.0 0.0 2.1 2 0 0 2 2 2 1 Winged helix-turn helix HTH_11 PF08279.12 AIC16679.1 - 0.083 12.9 0.0 0.2 11.6 0.0 1.7 1 0 0 1 1 1 0 HTH domain HTH_24 PF13412.6 AIC16679.1 - 0.087 12.4 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding NMT1_2 PF13379.6 AIC16680.1 - 1.7e-28 100.0 0.0 2.5e-28 99.5 0.0 1.2 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 AIC16680.1 - 1e-14 55.0 0.1 1.9e-14 54.2 0.1 1.5 1 1 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 AIC16680.1 - 3e-11 43.4 0.0 4.6e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 AIC16680.1 - 5.5e-06 26.0 0.0 0.015 14.7 0.0 2.4 1 1 1 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 NMT1_3 PF16868.5 AIC16680.1 - 0.044 13.2 0.1 0.085 12.3 0.0 1.6 2 0 0 2 2 2 0 NMT1-like family ScsC_N PF18312.1 AIC16680.1 - 1.1 9.1 0.0 1.1 9.1 0.0 3.1 4 0 0 4 4 4 0 Copper resistance protein ScsC N-terminal domain ABC_tran PF00005.27 AIC16681.1 - 1e-31 110.3 0.0 1.9e-31 109.4 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC16681.1 - 3.6e-09 36.9 0.1 0.00057 19.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIC16681.1 - 3.5e-05 23.4 0.2 0.1 12.0 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 AIC16681.1 - 0.00017 20.6 0.2 0.021 13.6 0.0 2.1 2 0 0 2 2 2 2 Predicted ATPase of the ABC class AAA PF00004.29 AIC16681.1 - 0.00044 20.7 0.3 0.009 16.4 0.3 2.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 AIC16681.1 - 0.00073 20.0 1.5 0.0042 17.5 1.1 2.5 1 1 1 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 AIC16681.1 - 0.00082 19.3 0.0 0.0016 18.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 AIC16681.1 - 0.0015 18.2 0.1 0.0035 17.1 0.1 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_25 PF13481.6 AIC16681.1 - 0.0027 17.3 0.0 0.058 13.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain Rad17 PF03215.15 AIC16681.1 - 0.0054 16.7 0.0 0.012 15.5 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_22 PF13401.6 AIC16681.1 - 0.01 16.1 2.0 0.025 14.8 0.9 2.4 2 1 0 2 2 1 1 AAA domain ATPase_2 PF01637.18 AIC16681.1 - 0.019 14.8 0.0 0.076 12.9 0.0 1.9 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 AIC16681.1 - 0.035 13.3 0.0 0.066 12.4 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_23 PF13476.6 AIC16681.1 - 0.051 14.1 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 AIC16681.1 - 0.062 12.7 0.0 0.2 11.1 0.0 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_15 PF13175.6 AIC16681.1 - 0.066 12.9 0.1 0.91 9.2 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain Stealth_CR3 PF17102.5 AIC16681.1 - 0.068 13.1 0.5 0.25 11.3 0.1 2.1 2 0 0 2 2 2 0 Stealth protein CR3, conserved region 3 AAA_30 PF13604.6 AIC16681.1 - 0.098 12.4 0.2 0.22 11.2 0.2 1.9 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 AIC16681.1 - 0.27 11.5 2.2 0.4 10.9 0.0 2.4 3 1 0 3 3 3 0 AAA domain BPD_transp_1 PF00528.22 AIC16682.1 - 2.1e-15 57.0 17.0 2.1e-15 57.0 17.0 2.1 2 1 0 2 2 2 1 Binding-protein-dependent transport system inner membrane component DLH PF01738.18 AIC16683.1 - 3.7e-56 190.1 0.0 4.9e-56 189.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 AIC16683.1 - 2.4e-10 40.3 0.2 3.6e-05 23.3 0.0 2.9 1 1 1 3 3 3 2 Prolyl oligopeptidase family BAAT_C PF08840.11 AIC16683.1 - 3.1e-10 40.4 0.6 0.0022 17.9 0.0 3.3 2 1 1 3 3 3 3 BAAT / Acyl-CoA thioester hydrolase C terminal Chlorophyllase PF07224.11 AIC16683.1 - 7.7e-05 21.9 0.0 9.7e-05 21.5 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase Chlorophyllase2 PF12740.7 AIC16683.1 - 0.00073 18.5 0.0 0.0015 17.5 0.0 1.6 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_2 PF02230.16 AIC16683.1 - 0.0037 17.1 0.0 0.0057 16.5 0.0 1.3 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase DUF3185 PF11381.8 AIC16683.1 - 0.04 13.9 2.3 0.2 11.7 2.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3185) Hydrolase_4 PF12146.8 AIC16683.1 - 0.12 11.6 0.0 4.2 6.6 0.0 2.1 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Copper-bind PF00127.20 AIC16684.1 - 1.4e-09 38.3 0.3 3.3e-09 37.1 0.3 1.7 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC16684.1 - 0.081 13.0 0.3 0.22 11.6 0.3 1.8 1 1 0 1 1 1 0 Cupredoxin-like domain BAR_2 PF10455.9 AIC16687.1 - 0.084 12.0 0.0 0.087 11.9 0.0 1.0 1 0 0 1 1 1 0 Bin/amphiphysin/Rvs domain for vesicular trafficking PfkB PF00294.24 AIC16688.1 - 2.7e-17 63.1 0.2 3.6e-17 62.6 0.2 1.1 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Pyr_redox PF00070.27 AIC16688.1 - 0.041 14.4 0.1 0.15 12.6 0.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase ADP_PFK_GK PF04587.15 AIC16688.1 - 0.056 12.0 0.0 1.7 7.1 0.0 2.1 2 0 0 2 2 2 0 ADP-specific Phosphofructokinase/Glucokinase conserved region Cpn60_TCP1 PF00118.24 AIC16689.1 - 2.4e-183 610.3 19.8 2.7e-183 610.1 19.8 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ustilago_mating PF05722.12 AIC16689.1 - 0.023 14.2 0.2 0.17 11.3 0.0 2.1 2 0 0 2 2 2 0 Ustilago B locus mating-type protein 4HBT PF03061.22 AIC16690.1 - 0.024 15.0 0.1 0.083 13.3 0.1 1.8 1 1 1 2 2 2 0 Thioesterase superfamily zf-C2H2 PF00096.26 AIC16691.1 - 0.0024 18.2 10.9 0.016 15.6 2.6 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zinc_ribbon_5 PF13719.6 AIC16691.1 - 0.0041 16.8 1.2 2.2 8.1 0.0 2.2 2 0 0 2 2 2 2 zinc-ribbon domain zf_UBZ PF18439.1 AIC16691.1 - 0.012 15.2 6.7 0.53 9.9 0.4 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 AIC16691.1 - 0.015 15.3 0.2 0.021 14.8 0.2 1.2 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_4 PF13717.6 AIC16691.1 - 0.019 14.9 2.9 0.35 10.8 2.9 2.2 1 1 0 1 1 1 0 zinc-ribbon domain zf-C2H2_4 PF13894.6 AIC16691.1 - 0.021 15.7 16.8 0.85 10.6 7.5 3.0 3 1 0 3 3 3 0 C2H2-type zinc finger zinc_ribbon_15 PF17032.5 AIC16691.1 - 0.047 14.4 3.0 0.13 13.1 2.2 1.8 1 1 1 2 2 2 0 zinc-ribbon family FUR PF01475.19 AIC16691.1 - 0.39 10.9 8.8 0.46 10.6 8.8 1.3 1 1 0 1 1 1 0 Ferric uptake regulator family Zn-ribbon_8 PF09723.10 AIC16691.1 - 0.55 10.4 6.1 1.2 9.3 5.0 2.0 1 1 1 2 2 2 0 Zinc ribbon domain FYVE PF01363.21 AIC16691.1 - 4.8 7.4 10.5 10 6.4 10.5 1.6 1 1 0 1 1 1 0 FYVE zinc finger Ribosomal_L44 PF00935.19 AIC16692.1 - 1.3e-25 89.6 10.9 1.3e-25 89.6 10.9 1.4 2 0 0 2 2 2 1 Ribosomal protein L44 Ribosomal_L33 PF00471.20 AIC16692.1 - 0.00093 19.6 9.8 0.0017 18.7 0.9 2.3 2 0 0 2 2 2 1 Ribosomal protein L33 NOB1_Zn_bind PF08772.11 AIC16692.1 - 0.0016 18.6 0.5 0.0016 18.6 0.5 2.1 1 1 0 2 2 2 1 Nin one binding (NOB1) Zn-ribbon like C1_4 PF07975.12 AIC16692.1 - 0.012 15.8 2.9 0.037 14.3 0.2 2.1 2 0 0 2 2 2 0 TFIIH C1-like domain zinc-ribbons_6 PF07191.12 AIC16692.1 - 0.032 14.2 1.5 2.6 8.1 0.1 2.1 2 0 0 2 2 2 0 zinc-ribbons Nudix_N_2 PF14803.6 AIC16692.1 - 0.039 13.9 1.3 2.6 8.0 0.1 2.4 2 0 0 2 2 2 0 Nudix N-terminal Rpr2 PF04032.16 AIC16692.1 - 0.18 12.1 5.5 0.37 11.1 5.5 1.6 1 1 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain DZR PF12773.7 AIC16692.1 - 0.23 11.5 5.5 0.47 10.5 5.5 1.5 1 1 0 1 1 1 0 Double zinc ribbon zf-Dof PF02701.15 AIC16692.1 - 0.31 11.2 8.3 0.22 11.7 0.7 2.6 2 1 0 2 2 2 0 Dof domain, zinc finger Ribosomal_L37ae PF01780.19 AIC16692.1 - 1.3 9.2 10.6 3.1 8.0 3.4 2.2 1 1 1 2 2 2 0 Ribosomal L37ae protein family zf_UBZ PF18439.1 AIC16692.1 - 4.1 7.1 5.2 9.5 5.9 0.4 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Ribosomal_S27e PF01667.17 AIC16693.1 - 3e-16 58.9 1.1 3.3e-16 58.7 1.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S27 TF_Zn_Ribbon PF08271.12 AIC16693.1 - 0.00097 18.6 0.1 0.0015 18.0 0.1 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding OrfB_Zn_ribbon PF07282.11 AIC16693.1 - 0.0023 17.8 0.9 0.0027 17.6 0.9 1.2 1 0 0 1 1 1 1 Putative transposase DNA-binding domain zinc_ribbon_4 PF13717.6 AIC16693.1 - 0.0029 17.5 1.3 1.6 8.7 0.2 2.2 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 AIC16693.1 - 0.0098 15.9 0.6 0.013 15.5 0.6 1.3 1 0 0 1 1 1 1 Double zinc ribbon DNA_RNApol_7kD PF03604.13 AIC16693.1 - 0.0098 15.5 0.8 0.74 9.6 0.1 2.2 2 0 0 2 2 2 1 DNA directed RNA polymerase, 7 kDa subunit zinc_ribbon_2 PF13240.6 AIC16693.1 - 0.015 15.0 0.9 1.4 8.7 0.1 2.2 2 0 0 2 2 2 0 zinc-ribbon domain HypA PF01155.19 AIC16693.1 - 0.016 15.2 0.6 0.019 15.0 0.6 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-ACC PF17848.1 AIC16693.1 - 0.017 15.2 4.0 0.62 10.2 0.2 2.2 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain zf-RING_9 PF13901.6 AIC16693.1 - 0.022 14.8 0.5 0.024 14.6 0.5 1.1 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon Lar_restr_allev PF14354.6 AIC16693.1 - 0.024 15.0 0.3 0.033 14.6 0.3 1.2 1 0 0 1 1 1 0 Restriction alleviation protein Lar zf-ribbon_3 PF13248.6 AIC16693.1 - 0.044 13.2 1.8 1.3 8.6 0.1 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIC16693.1 - 0.049 13.8 2.0 0.083 13.0 2.0 1.4 1 1 0 1 1 1 0 Zinc ribbon domain Zn_Tnp_IS91 PF14319.6 AIC16693.1 - 0.053 13.6 0.6 0.063 13.3 0.6 1.1 1 0 0 1 1 1 0 Transposase zinc-binding domain zinc_ribbon_6 PF14599.6 AIC16693.1 - 0.07 13.2 0.2 0.1 12.6 0.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon HalOD2 PF18547.1 AIC16693.1 - 0.1 12.5 0.5 0.1 12.5 0.5 2.1 1 1 1 2 2 2 0 Halobacterial output domain 2 CpXC PF14353.6 AIC16693.1 - 0.13 12.3 2.2 7.1 6.7 0.2 2.1 1 1 1 2 2 2 0 CpXC protein TFIIS_C PF01096.18 AIC16693.1 - 0.15 11.9 2.8 1.6 8.7 0.2 2.1 1 1 2 3 3 3 0 Transcription factor S-II (TFIIS) zf_UBZ PF18439.1 AIC16693.1 - 0.17 11.5 0.9 8.4 6.1 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-ISL3 PF14690.6 AIC16693.1 - 0.32 11.7 3.3 5 7.9 0.0 2.3 2 1 1 3 3 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-C2HC_2 PF13913.6 AIC16693.1 - 0.34 10.9 3.9 12 5.9 1.1 2.2 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-LSD1 PF06943.12 AIC16693.1 - 0.84 9.5 4.2 2.6 8.0 0.3 2.3 2 0 0 2 2 2 0 LSD1 zinc finger NTP_transf_3 PF12804.7 AIC16694.1 - 4.4e-17 62.9 0.3 6e-17 62.5 0.3 1.3 1 1 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 AIC16694.1 - 3e-09 36.9 0.1 4.5e-09 36.4 0.1 1.3 1 0 0 1 1 1 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase CTP_transf_3 PF02348.19 AIC16694.1 - 0.00028 20.9 0.0 0.00053 20.0 0.0 1.5 1 1 0 1 1 1 1 Cytidylyltransferase CofC PF01983.16 AIC16694.1 - 0.0047 16.1 0.2 0.0086 15.3 0.0 1.5 2 0 0 2 2 2 1 Guanylyl transferase CofC like GFO_IDH_MocA PF01408.22 AIC16694.1 - 0.015 16.1 0.1 0.045 14.6 0.0 2.0 2 1 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold CobS PF02654.15 AIC16695.1 - 2e-41 142.4 18.3 2.3e-41 142.2 18.3 1.0 1 0 0 1 1 1 1 Cobalamin-5-phosphate synthase CobD_Cbib PF03186.13 AIC16696.1 - 2.6e-88 295.8 2.7 3.4e-88 295.5 2.7 1.1 1 0 0 1 1 1 1 CobD/Cbib protein DUF2374 PF09574.10 AIC16696.1 - 8.9 6.2 8.3 1.6 8.6 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (Duf2374) CbiA PF01656.23 AIC16697.1 - 1.2e-20 73.8 0.0 1.6e-20 73.4 0.0 1.1 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_26 PF13500.6 AIC16697.1 - 1e-17 64.6 0.0 1.1e-16 61.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain MobB PF03205.14 AIC16697.1 - 0.00059 19.7 0.0 0.0049 16.8 0.0 2.1 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B AAA_30 PF13604.6 AIC16697.1 - 0.051 13.3 0.1 0.09 12.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 AIC16697.1 - 0.13 12.8 0.0 0.17 12.4 0.0 1.3 1 0 0 1 1 1 0 ABC transporter VirC1 PF07015.11 AIC16697.1 - 0.16 11.2 0.0 0.35 10.1 0.0 1.6 1 0 0 1 1 1 0 VirC1 protein Aminotran_1_2 PF00155.21 AIC16698.1 - 8.3e-46 156.8 0.0 1.1e-45 156.4 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Semialdhyde_dhC PF02774.18 AIC16699.1 - 1.4e-37 129.6 0.0 2.1e-37 129.0 0.0 1.2 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, dimerisation domain Semialdhyde_dh PF01118.24 AIC16699.1 - 2.2e-26 92.6 0.0 4.1e-26 91.8 0.0 1.5 1 0 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Gp_dh_C PF02800.20 AIC16699.1 - 0.00018 21.1 0.3 0.062 12.9 0.0 2.6 3 0 0 3 3 3 2 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain DapB_N PF01113.20 AIC16699.1 - 0.0019 18.3 0.0 0.0044 17.2 0.0 1.6 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus CarboxypepD_reg PF13620.6 AIC16700.1 - 0.0077 16.5 1.2 0.01 16.1 0.1 1.8 2 0 0 2 2 2 1 Carboxypeptidase regulatory-like domain AlcCBM31 PF11606.8 AIC16700.1 - 0.27 11.5 0.9 29 4.9 0.0 2.7 1 1 1 2 2 2 0 Family 31 carbohydrate binding protein SLATT_5 PF18160.1 AIC16700.1 - 0.92 8.8 3.0 1.5 8.1 3.0 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 ABC2_membrane PF01061.24 AIC16700.1 - 2.4 7.5 6.1 15 4.9 6.1 2.0 1 1 0 1 1 1 0 ABC-2 type transporter AsnC_trans_reg PF01037.21 AIC16701.1 - 9.5e-15 54.3 0.1 1.6e-14 53.6 0.1 1.4 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 AIC16701.1 - 2.1e-13 49.6 0.7 4.1e-13 48.7 0.7 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC16701.1 - 2.4e-09 36.9 0.0 5.1e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain MarR PF01047.22 AIC16701.1 - 2.5e-06 27.3 0.0 5.7e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIC16701.1 - 2.1e-05 24.3 0.7 4.2e-05 23.4 0.1 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB B-block_TFIIIC PF04182.12 AIC16701.1 - 0.00033 20.7 1.0 0.00047 20.3 0.9 1.5 1 1 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_11 PF08279.12 AIC16701.1 - 0.00049 20.0 0.4 0.0011 18.9 0.4 1.5 1 0 0 1 1 1 1 HTH domain Ribosomal_S25 PF03297.15 AIC16701.1 - 0.0022 18.2 2.7 0.0031 17.7 0.9 1.9 2 0 0 2 2 2 1 S25 ribosomal protein HTH_5 PF01022.20 AIC16701.1 - 0.0063 16.4 0.3 0.013 15.4 0.3 1.6 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family Rrf2 PF02082.20 AIC16701.1 - 0.0065 16.8 0.1 0.014 15.7 0.1 1.5 1 0 0 1 1 1 1 Transcriptional regulator HTH_20 PF12840.7 AIC16701.1 - 0.0066 16.5 0.0 0.024 14.7 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain MarR_2 PF12802.7 AIC16701.1 - 0.017 15.0 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 MarR family Mga PF05043.13 AIC16701.1 - 0.036 14.6 0.4 0.074 13.6 0.1 1.6 2 0 0 2 2 2 0 Mga helix-turn-helix domain HTH_34 PF13601.6 AIC16701.1 - 0.048 13.8 0.1 0.092 12.9 0.1 1.6 1 0 0 1 1 1 0 Winged helix DNA-binding domain Fe_dep_repress PF01325.19 AIC16701.1 - 0.096 12.9 0.2 0.23 11.7 0.2 1.6 1 0 0 1 1 1 0 Iron dependent repressor, N-terminal DNA binding domain UbiA PF01040.18 AIC16702.1 - 1.6e-52 178.3 21.8 2e-52 178.0 21.8 1.1 1 0 0 1 1 1 1 UbiA prenyltransferase family VIT1 PF01988.19 AIC16702.1 - 7.5 6.4 16.4 0.24 11.2 1.0 2.6 3 0 0 3 3 3 0 VIT family EMG1 PF03587.14 AIC16703.1 - 9e-42 142.9 0.0 1e-41 142.8 0.0 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Rpr2 PF04032.16 AIC16704.1 - 1.3e-13 51.0 0.4 1.5e-13 50.8 0.4 1.1 1 0 0 1 1 1 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain DUF4636 PF15468.6 AIC16704.1 - 0.0052 16.5 0.1 0.006 16.3 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4636) PapD-like PF14874.6 AIC16704.1 - 0.03 14.5 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 Flagellar-associated PapD-like zinc_ribbon_4 PF13717.6 AIC16704.1 - 0.051 13.5 1.1 4.6 7.2 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DUF572 PF04502.13 AIC16704.1 - 0.13 11.8 0.7 0.14 11.7 0.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Ribosomal_S19e PF01090.19 AIC16705.1 - 1.8e-54 183.1 0.1 2.1e-54 182.9 0.1 1.0 1 0 0 1 1 1 1 Ribosomal protein S19e dsDNA_bind PF01984.20 AIC16706.1 - 1.2e-24 86.7 1.3 1.2e-24 86.7 1.3 1.0 1 0 0 1 1 1 1 Double-stranded DNA-binding domain Tom5 PF10642.9 AIC16706.1 - 0.0091 16.0 0.4 0.021 14.9 0.4 1.7 1 0 0 1 1 1 1 Mitochondrial import receptor subunit or translocase ADH_zinc_N PF00107.26 AIC16707.1 - 5.6e-28 97.5 0.2 1e-27 96.7 0.2 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 AIC16707.1 - 5.7e-27 93.8 0.0 1.2e-26 92.7 0.0 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N_2 PF13602.6 AIC16707.1 - 2.4e-17 64.2 0.0 4.7e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase HpcH_HpaI PF03328.14 AIC16708.1 - 3.9e-48 163.5 2.5 5e-48 163.2 2.5 1.1 1 0 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family C-C_Bond_Lyase PF15617.6 AIC16708.1 - 1.8e-17 63.5 0.3 2.5e-08 33.5 0.0 2.1 1 1 1 2 2 2 2 C-C_Bond_Lyase of the TIM-Barrel fold RRM_2 PF04059.12 AIC16708.1 - 0.04 14.1 0.0 1.2 9.4 0.0 2.2 1 1 1 2 2 2 0 RNA recognition motif 2 SBF PF01758.16 AIC16709.1 - 6.6e-12 45.5 15.0 6.6e-12 45.5 15.0 1.6 2 0 0 2 2 2 1 Sodium Bile acid symporter family Peptidase_M3 PF01432.20 AIC16710.1 - 5.5e-46 157.8 0.0 7.9e-46 157.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M3_N PF08439.10 AIC16710.1 - 1.6e-08 34.7 0.3 1.6e-06 28.3 0.2 3.1 3 0 0 3 3 3 1 Oligopeptidase F CAP PF00188.26 AIC16711.1 - 1.7e-06 28.9 0.0 3.6e-06 27.8 0.0 1.6 1 1 0 1 1 1 1 Cysteine-rich secretory protein family DUF167 PF02594.16 AIC16712.1 - 3e-15 56.1 0.1 3.2e-15 56.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 DNA_alkylation PF08713.11 AIC16713.1 - 2.4e-69 233.3 0.2 2.7e-69 233.2 0.2 1.0 1 0 0 1 1 1 1 DNA alkylation repair enzyme U-box PF04564.15 AIC16713.1 - 0.18 12.0 0.0 0.31 11.2 0.0 1.4 1 0 0 1 1 1 0 U-box domain Glyco_trans_2_3 PF13632.6 AIC16715.1 - 2.2e-10 40.8 0.1 3.8e-10 40.0 0.1 1.5 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Glyco_tranf_2_3 PF13641.6 AIC16715.1 - 2.1e-05 24.6 0.1 4.5e-05 23.5 0.1 1.5 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Fringe PF02434.16 AIC16715.1 - 6.7e-05 22.4 0.1 0.0001 21.9 0.1 1.2 1 0 0 1 1 1 1 Fringe-like PBP_like_2 PF12849.7 AIC16717.1 - 2.5e-23 83.1 2.2 3.5e-23 82.7 2.2 1.1 1 0 0 1 1 1 1 PBP superfamily domain Glycos_transf_1 PF00534.20 AIC16718.1 - 2.8e-20 72.6 0.0 5.1e-20 71.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 AIC16718.1 - 4e-09 37.0 0.1 2e-08 34.7 0.0 2.0 2 0 0 2 2 2 1 Glycosyl transferases group 1 ALG11_N PF15924.5 AIC16718.1 - 0.02 15.0 0.0 0.054 13.5 0.1 1.7 2 0 0 2 2 2 0 ALG11 mannosyltransferase N-terminus Dodecin PF07311.12 AIC16719.1 - 5.7e-24 84.1 1.3 6.3e-24 84.0 1.3 1.0 1 0 0 1 1 1 1 Dodecin DUF608 PF04685.13 AIC16720.1 - 5.1e-08 32.5 0.0 7.9e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl-hydrolase family 116, catalytic region GDE_C PF06202.14 AIC16720.1 - 0.0012 17.9 0.4 1.3 7.9 0.2 2.3 1 1 0 2 2 2 2 Amylo-alpha-1,6-glucosidase Bac_rhamnosid6H PF17389.2 AIC16720.1 - 0.055 12.7 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Trehalase PF01204.18 AIC16720.1 - 0.062 12.1 0.0 0.089 11.6 0.0 1.2 1 0 0 1 1 1 0 Trehalase TPR_10 PF13374.6 AIC16720.1 - 0.16 11.9 0.1 0.36 10.8 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat FMN_red PF03358.15 AIC16721.1 - 0.021 14.6 0.1 0.023 14.4 0.1 1.1 1 0 0 1 1 1 0 NADPH-dependent FMN reductase FMN_red PF03358.15 AIC16722.1 - 0.00021 21.1 0.1 0.00033 20.4 0.1 1.3 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Tn7_Tnp_TnsA_C PF08721.11 AIC16722.1 - 0.032 14.9 0.0 0.042 14.5 0.0 1.3 1 0 0 1 1 1 0 TnsA endonuclease C terminal Rubrerythrin PF02915.17 AIC16727.1 - 2.6e-05 24.6 0.3 2.8e-05 24.5 0.3 1.1 1 0 0 1 1 1 1 Rubrerythrin Ferritin PF00210.24 AIC16727.1 - 0.0051 16.7 0.9 0.0056 16.6 0.9 1.2 1 0 0 1 1 1 1 Ferritin-like domain Ferritin_2 PF13668.6 AIC16727.1 - 0.011 16.0 0.1 0.013 15.7 0.1 1.4 1 1 0 1 1 1 0 Ferritin-like domain ASFV_J13L PF05568.11 AIC16728.1 - 0.14 11.9 0.2 0.15 11.8 0.2 1.1 1 0 0 1 1 1 0 African swine fever virus J13L protein ATP-grasp_5 PF13549.6 AIC16729.1 - 1.1e-82 276.8 0.2 2.3e-82 275.8 0.2 1.5 1 0 0 1 1 1 1 ATP-grasp domain Succ_CoA_lig PF13607.6 AIC16729.1 - 1.6e-54 183.4 1.4 1.6e-54 183.4 1.4 2.0 2 0 0 2 2 2 1 Succinyl-CoA ligase like flavodoxin domain CoA_binding_2 PF13380.6 AIC16729.1 - 6e-23 81.6 0.3 6.1e-21 75.1 0.0 3.5 3 0 0 3 3 3 1 CoA binding domain CoA_binding PF02629.19 AIC16729.1 - 1e-11 45.3 2.5 1.6e-11 44.7 0.6 2.3 2 0 0 2 2 2 1 CoA binding domain ATP-grasp_2 PF08442.10 AIC16729.1 - 4.7e-06 26.3 0.4 1.1e-05 25.1 0.1 1.9 2 0 0 2 2 2 1 ATP-grasp domain CPSase_L_D2 PF02786.17 AIC16729.1 - 0.0041 16.7 0.1 0.0082 15.7 0.1 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Pan3_PK PF18101.1 AIC16729.1 - 0.021 14.8 0.1 0.046 13.7 0.1 1.5 1 0 0 1 1 1 0 Pan3 Pseudokinase domain YIEGIA PF14045.6 AIC16729.1 - 0.026 13.4 0.0 0.05 12.4 0.0 1.4 1 0 0 1 1 1 0 YIEGIA protein Glyoxalase PF00903.25 AIC16730.1 - 3.6e-11 43.3 0.0 2e-10 41.0 0.0 1.9 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 AIC16730.1 - 4.8e-07 30.0 0.0 9.3e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIC16730.1 - 0.014 16.2 0.0 0.057 14.2 0.0 1.9 1 1 0 1 1 1 0 Glyoxalase-like domain Glyoxalase_3 PF13468.6 AIC16730.1 - 0.03 14.5 0.1 2.9 8.0 0.0 2.1 2 0 0 2 2 2 0 Glyoxalase-like domain DZR PF12773.7 AIC16731.1 - 8.9e-08 32.0 6.5 4.4e-05 23.4 1.7 2.3 2 0 0 2 2 2 2 Double zinc ribbon zinc_ribbon_2 PF13240.6 AIC16731.1 - 1.1e-07 31.4 5.1 1.1e-07 31.4 5.1 2.9 3 0 0 3 3 3 1 zinc-ribbon domain PRC PF05239.16 AIC16731.1 - 0.00035 20.6 0.4 0.00055 20.0 0.4 1.3 1 0 0 1 1 1 1 PRC-barrel domain zinc_ribbon_15 PF17032.5 AIC16731.1 - 0.0004 21.1 2.5 0.047 14.4 0.1 2.4 2 1 0 2 2 2 1 zinc-ribbon family zf-ribbon_3 PF13248.6 AIC16731.1 - 0.00065 19.0 3.1 0.00065 19.0 3.1 2.7 3 0 0 3 3 3 1 zinc-ribbon domain zinc-ribbons_6 PF07191.12 AIC16731.1 - 0.0014 18.6 2.1 1.9 8.5 0.1 3.1 3 0 0 3 3 3 1 zinc-ribbons zf-RanBP PF00641.18 AIC16731.1 - 0.0029 16.9 1.0 0.0029 16.9 1.0 2.6 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others Zn-ribbon_8 PF09723.10 AIC16731.1 - 0.069 13.3 14.0 5.2 7.3 0.1 4.1 3 1 1 4 4 4 0 Zinc ribbon domain Cript PF10235.9 AIC16731.1 - 0.1 13.2 2.6 1.6 9.4 0.1 2.5 3 0 0 3 3 2 0 Microtubule-associated protein CRIPT DUF2757 PF10955.8 AIC16731.1 - 0.11 12.7 2.6 13 6.1 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) HypA PF01155.19 AIC16731.1 - 0.25 11.4 5.7 2.9 7.9 0.5 2.6 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ephrin_rec_like PF07699.13 AIC16731.1 - 0.43 10.4 9.8 0.25 11.1 3.0 2.8 3 0 0 3 3 3 0 Putative ephrin-receptor like zf-B_box PF00643.24 AIC16731.1 - 1.3 9.3 8.6 2.7 8.2 0.4 2.8 3 0 0 3 3 3 0 B-box zinc finger PHD PF00628.29 AIC16731.1 - 3.1 7.8 6.5 25 4.9 0.1 3.2 3 0 0 3 3 3 0 PHD-finger TF_Zn_Ribbon PF08271.12 AIC16731.1 - 9.4 5.8 9.8 0.77 9.3 2.0 2.8 3 0 0 3 3 3 0 TFIIB zinc-binding ABC2_membrane PF01061.24 AIC16732.1 - 9.6e-23 80.7 22.3 1.3e-22 80.2 22.3 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIC16732.1 - 1.9e-10 40.4 23.4 1.9e-10 40.4 23.4 2.1 1 1 1 2 2 2 2 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 AIC16732.1 - 1e-05 25.0 20.5 2.2e-05 23.9 20.5 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_4 PF12730.7 AIC16732.1 - 0.00028 20.9 13.3 0.0011 19.0 13.2 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_5 PF13346.6 AIC16732.1 - 0.0032 17.1 24.3 0.067 12.7 24.3 2.3 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 AIC16733.1 - 1.1e-29 103.7 0.0 1.9e-29 102.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC16733.1 - 3.1e-12 46.9 0.2 1.4e-06 28.3 0.1 2.3 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 AIC16733.1 - 2e-05 25.2 0.0 5.7e-05 23.8 0.0 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) AAA_23 PF13476.6 AIC16733.1 - 0.0023 18.5 0.0 0.0037 17.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIC16733.1 - 0.021 14.6 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 AIC16733.1 - 0.021 14.5 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_15 PF13175.6 AIC16733.1 - 0.025 14.3 0.0 4 7.0 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 AIC16733.1 - 0.042 13.6 0.1 0.08 12.7 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain MobB PF03205.14 AIC16733.1 - 0.079 12.9 0.2 13 5.7 0.1 2.5 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B tRNA_anti-codon PF01336.25 AIC16734.1 - 7e-13 48.4 3.6 0.0016 18.4 0.1 3.7 3 0 0 3 3 3 3 OB-fold nucleic acid binding domain CDC24_OB3 PF17244.2 AIC16734.1 - 5.9e-05 22.9 0.1 0.1 12.3 0.0 2.3 2 0 0 2 2 2 2 Cell division control protein 24, OB domain 3 POT1PC PF16686.5 AIC16734.1 - 0.00061 19.7 0.0 0.83 9.5 0.0 3.2 3 0 0 3 3 3 1 ssDNA-binding domain of telomere protection protein REPA_OB_2 PF16900.5 AIC16734.1 - 0.0019 18.1 4.1 0.019 14.9 0.0 3.2 3 0 0 3 3 3 1 Replication protein A OB domain tRNA_anti_2 PF13742.6 AIC16734.1 - 0.092 13.0 0.4 16 5.7 0.0 3.4 3 1 0 3 3 3 0 OB-fold nucleic acid binding domain NfeD PF01957.18 AIC16734.1 - 1.1 9.7 4.5 2.3 8.6 0.1 3.2 3 1 1 4 4 4 0 NfeD-like C-terminal, partner-binding GCS2 PF04107.13 AIC16735.1 - 8.5e-06 25.3 0.0 1.6e-05 24.4 0.0 1.5 1 1 0 1 1 1 1 Glutamate-cysteine ligase family 2(GCS2) CBS PF00571.28 AIC16738.1 - 3e-26 91.6 2.9 2.1e-12 47.3 0.3 2.1 2 0 0 2 2 2 2 CBS domain DEAD PF00270.29 AIC16739.1 - 1.1e-31 109.9 0.1 2.4e-31 108.9 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEAD_assoc PF08494.11 AIC16739.1 - 5e-28 98.2 0.2 1.2e-27 97.0 0.1 1.8 2 0 0 2 2 2 1 DEAD/H associated Helicase_C PF00271.31 AIC16739.1 - 4.8e-23 81.6 0.1 4.6e-21 75.2 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 AIC16739.1 - 6.4e-09 36.0 0.0 1.4e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SNF2_N PF00176.23 AIC16739.1 - 0.00012 20.9 0.0 0.0011 17.8 0.0 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain HypA PF01155.19 AIC16739.1 - 0.012 15.6 0.6 0.048 13.7 0.6 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 AIC16739.1 - 0.013 15.6 0.5 0.029 14.5 0.5 1.6 1 0 0 1 1 1 0 Zinc ribbon domain TackOD1 PF18551.1 AIC16739.1 - 0.13 11.9 0.1 0.24 11.0 0.1 1.4 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 MRC1 PF09444.10 AIC16739.1 - 0.14 12.7 1.3 0.9 10.0 0.2 2.4 2 0 0 2 2 2 0 MRC1-like domain Cas_APE2256 PF09651.10 AIC16739.1 - 0.16 11.8 0.4 3.3 7.6 0.0 3.1 4 0 0 4 4 4 0 CRISPR-associated protein (Cas_APE2256) NCE101 PF11654.8 AIC16740.1 - 0.018 14.7 0.1 0.53 10.0 0.1 2.1 1 1 0 1 1 1 0 Non-classical export protein 1 AIF_C PF14721.6 AIC16740.1 - 0.035 14.5 0.1 0.037 14.4 0.1 1.0 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term FAA_hydrolase_N PF09298.11 AIC16740.1 - 0.055 13.7 0.0 0.061 13.5 0.0 1.1 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal LapA_dom PF06305.11 AIC16740.1 - 0.058 13.2 0.0 0.069 13.0 0.0 1.1 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain EphA2_TM PF14575.6 AIC16740.1 - 0.11 13.4 0.0 0.13 13.1 0.0 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Spore_YpjB PF09577.10 AIC16741.1 - 0.013 15.3 4.2 0.25 11.1 0.0 4.1 3 2 2 5 5 5 0 Sporulation protein YpjB (SpoYpjB) Herpes_UL17 PF04559.12 AIC16741.1 - 2.3 6.9 11.0 0.088 11.6 1.5 2.7 2 1 2 4 4 4 0 Herpesvirus UL17 protein Fzo_mitofusin PF04799.13 AIC16743.1 - 0.028 14.0 1.3 0.038 13.5 1.3 1.2 1 0 0 1 1 1 0 fzo-like conserved region SOP4 PF17081.5 AIC16744.1 - 0.0028 17.2 0.1 0.0033 17.0 0.1 1.1 1 0 0 1 1 1 1 Suppressor of PMA 1-7 protein TrmB PF01978.19 AIC16744.1 - 0.014 15.3 0.1 0.021 14.7 0.1 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_20 PF12840.7 AIC16744.1 - 0.046 13.8 0.0 0.08 13.0 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Yip1 PF04893.17 AIC16745.1 - 1.2 8.8 16.9 1.8 8.2 16.9 1.3 1 0 0 1 1 1 0 Yip1 domain DDE_Tnp_IS240 PF13610.6 AIC16748.1 - 4.5e-20 72.3 4.2 1e-19 71.1 4.2 1.7 1 0 0 1 1 1 1 DDE domain rve PF00665.26 AIC16748.1 - 2.6e-06 27.6 0.3 5e-06 26.7 0.3 1.5 1 0 0 1 1 1 1 Integrase core domain SWIM PF04434.17 AIC16748.1 - 1.5e-05 24.5 0.2 4e-05 23.2 0.2 1.7 1 0 0 1 1 1 1 SWIM zinc finger rve_3 PF13683.6 AIC16748.1 - 0.00018 21.2 0.4 0.00045 20.0 0.0 1.9 2 0 0 2 2 2 1 Integrase core domain Transposase_mut PF00872.18 AIC16748.1 - 0.0013 17.7 0.3 0.14 11.0 0.0 2.2 2 0 0 2 2 2 2 Transposase, Mutator family Apo-CIII PF05778.12 AIC16748.1 - 0.11 12.2 0.2 0.31 10.7 0.2 1.7 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) Pox_A14 PF05767.12 AIC16749.1 - 1.4 9.1 6.0 16 5.7 6.0 2.0 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 DBB PF14545.6 AIC16750.1 - 0.096 12.6 0.2 0.2 11.6 0.0 1.5 2 0 0 2 2 2 0 Dof, BCAP, and BANK (DBB) motif, CopG_antitoxin PF12441.8 AIC16753.1 - 0.012 16.2 0.1 0.024 15.2 0.1 1.6 1 0 0 1 1 1 0 CopG antitoxin of type II toxin-antitoxin system YaaC PF14175.6 AIC16753.1 - 0.041 13.1 0.3 0.05 12.8 0.3 1.2 1 0 0 1 1 1 0 YaaC-like Protein Collagen PF01391.18 AIC16755.1 - 0.062 13.1 1.8 0.062 13.1 1.8 2.1 2 0 0 2 2 2 0 Collagen triple helix repeat (20 copies) SurA_N_3 PF13624.6 AIC16755.1 - 0.066 13.0 0.1 0.086 12.6 0.1 1.2 1 0 0 1 1 1 0 SurA N-terminal domain OppC_N PF12911.7 AIC16755.1 - 0.58 10.2 1.8 1.5 8.8 1.8 1.7 1 1 0 1 1 1 0 N-terminal TM domain of oligopeptide transport permease C DZR PF12773.7 AIC16758.1 - 0.016 15.2 0.3 0.024 14.7 0.3 1.2 1 0 0 1 1 1 0 Double zinc ribbon Fusion_gly PF00523.18 AIC16759.1 - 0.066 11.5 0.9 0.088 11.0 0.9 1.1 1 0 0 1 1 1 0 Fusion glycoprotein F0 UCR_Fe-S_N PF10399.9 AIC16759.1 - 1.7 8.0 10.0 3.4 7.1 10.0 1.5 1 0 0 1 1 1 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal DDE_Tnp_IS240 PF13610.6 AIC16762.1 - 1.3e-21 77.3 1.3 2.9e-21 76.2 1.3 1.6 1 0 0 1 1 1 1 DDE domain rve PF00665.26 AIC16762.1 - 3e-08 33.9 0.1 7.7e-08 32.5 0.1 1.6 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 AIC16762.1 - 2.2e-05 24.1 0.6 9.8e-05 22.1 0.2 2.3 2 1 0 2 2 2 1 Integrase core domain EPF PF17181.4 AIC16762.1 - 0.0028 17.6 3.8 1.1 9.3 1.2 2.5 2 0 0 2 2 2 2 Epidermal patterning factor proteins Zn-ribbon_8 PF09723.10 AIC16762.1 - 0.012 15.7 1.2 2.5 8.3 0.2 2.8 2 1 0 2 2 2 0 Zinc ribbon domain Zn_Tnp_IS1 PF03811.13 AIC16762.1 - 0.025 14.3 3.6 0.025 14.3 3.6 2.4 2 0 0 2 2 2 0 InsA N-terminal domain CpXC PF14353.6 AIC16762.1 - 0.043 13.9 1.4 0.081 13.0 0.2 2.1 2 2 0 2 2 2 0 CpXC protein C1_4 PF07975.12 AIC16762.1 - 0.51 10.6 6.1 0.95 9.7 1.4 2.4 2 0 0 2 2 2 0 TFIIH C1-like domain Fer4_9 PF13187.6 AIC16762.1 - 0.65 10.2 4.0 0.35 11.1 1.6 1.9 2 0 0 2 2 2 0 4Fe-4S dicluster domain MazE_antitoxin PF04014.18 AIC16763.1 - 0.0015 18.4 0.1 0.0028 17.5 0.0 1.5 2 0 0 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin DUF308 PF03729.13 AIC16764.1 - 9.1e-11 41.9 50.8 0.00011 22.5 10.0 3.1 1 1 2 3 3 3 3 Short repeat of unknown function (DUF308) DUF2892 PF11127.8 AIC16764.1 - 2.5 8.2 39.6 2.2 8.4 8.0 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2892) Imm40 PF15569.6 AIC16769.1 - 0.071 13.2 0.0 0.085 13.0 0.0 1.1 1 0 0 1 1 1 0 Immunity protein 40 Latarcin PF10279.9 AIC16771.1 - 0.019 15.3 0.0 0.021 15.2 0.0 1.1 1 0 0 1 1 1 0 Latarcin precursor ABC2_membrane PF01061.24 AIC16777.1 - 3.3e-37 128.0 21.9 4.3e-37 127.6 21.9 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 AIC16777.1 - 3.8e-14 52.6 28.9 3.8e-14 52.6 28.9 1.4 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 AIC16777.1 - 8.6e-08 31.8 18.6 8.6e-08 31.8 18.6 2.0 2 0 0 2 2 2 1 ABC-2 family transporter protein DUF5325 PF17259.2 AIC16777.1 - 5.2 7.0 12.0 2.8 7.9 3.1 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5325) MscL PF01741.18 AIC16777.1 - 5.5 7.3 7.0 1.6 9.0 2.2 2.1 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL ABC_tran PF00005.27 AIC16778.1 - 6e-32 111.0 0.0 9.4e-32 110.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC16778.1 - 2.3e-08 34.2 1.3 9.6e-06 25.6 0.0 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 AIC16778.1 - 3.4e-06 27.0 0.0 0.072 12.8 0.0 2.2 2 0 0 2 2 2 2 AAA ATPase domain DUF4162 PF13732.6 AIC16778.1 - 4.9e-05 24.0 0.0 0.00011 22.8 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) SRP54 PF00448.22 AIC16778.1 - 0.00053 19.7 0.1 0.0012 18.6 0.1 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_29 PF13555.6 AIC16778.1 - 0.0015 18.2 0.3 0.0031 17.2 0.3 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 AIC16778.1 - 0.0022 18.3 0.1 0.0069 16.7 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 AIC16778.1 - 0.0034 17.8 0.1 0.051 14.0 0.1 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 AIC16778.1 - 0.0035 17.9 0.0 0.0059 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 AIC16778.1 - 0.057 13.1 0.5 3.6 7.3 0.0 2.8 2 1 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 AIC16778.1 - 0.087 13.1 0.0 0.19 12.0 0.0 1.6 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit Zeta_toxin PF06414.12 AIC16778.1 - 0.11 11.8 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_27 PF13514.6 AIC16778.1 - 0.12 12.0 0.0 0.21 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 AIC16778.1 - 0.13 12.0 0.0 0.83 9.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain zf-ribbon_3 PF13248.6 AIC16779.1 - 0.0037 16.6 3.1 0.19 11.2 0.4 2.2 2 0 0 2 2 2 2 zinc-ribbon domain HypA PF01155.19 AIC16779.1 - 0.01 15.9 0.6 0.011 15.7 0.6 1.1 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zinc_ribbon_15 PF17032.5 AIC16779.1 - 0.014 16.2 1.0 0.016 16.0 1.0 1.1 1 0 0 1 1 1 0 zinc-ribbon family zinc_ribbon_2 PF13240.6 AIC16779.1 - 0.024 14.3 3.3 0.13 12.0 0.5 2.2 2 0 0 2 2 2 0 zinc-ribbon domain GFA PF04828.14 AIC16779.1 - 0.028 14.7 2.3 0.066 13.6 2.3 1.6 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme DZR PF12773.7 AIC16779.1 - 0.052 13.6 4.1 0.11 12.5 4.1 1.5 1 1 0 1 1 1 0 Double zinc ribbon PknG_rubred PF16919.5 AIC16779.1 - 0.14 12.4 2.5 0.23 11.6 2.5 1.5 1 1 0 1 1 1 0 Protein kinase G rubredoxin domain zinc_ribbon_4 PF13717.6 AIC16779.1 - 0.18 11.7 8.6 1.2 9.2 8.6 1.9 1 1 0 1 1 1 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 AIC16779.1 - 0.35 11.1 6.2 1.1 9.4 0.5 2.3 1 1 1 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) CpXC PF14353.6 AIC16779.1 - 0.4 10.7 3.9 9.2 6.3 0.1 2.0 1 1 1 2 2 2 0 CpXC protein DUF1451 PF07295.11 AIC16779.1 - 0.77 9.8 3.3 2.6 8.0 3.3 1.7 1 1 0 1 1 1 0 Zinc-ribbon containing domain zf-RanBP PF00641.18 AIC16779.1 - 3.2 7.2 7.0 6.4 6.2 0.6 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others ADK_lid PF05191.14 AIC16779.1 - 8.8 6.4 7.3 30 4.7 7.3 1.9 1 1 0 1 1 1 0 Adenylate kinase, active site lid RNA_binding PF01877.17 AIC16780.1 - 2.8e-09 37.3 0.0 7.5e-09 35.9 0.0 1.6 1 1 0 1 1 1 1 RNA binding AAA_17 PF13207.6 AIC16781.1 - 8.9e-16 58.5 0.1 1.5e-15 57.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 AIC16781.1 - 2.4e-15 57.2 0.0 3.3e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain ADK PF00406.22 AIC16781.1 - 4.2e-06 26.9 0.1 4.9e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Adenylate kinase AAA_33 PF13671.6 AIC16781.1 - 8.1e-06 26.0 0.1 5.5e-05 23.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 AIC16781.1 - 0.00021 21.5 0.0 0.00035 20.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain CoaE PF01121.20 AIC16781.1 - 0.00028 20.6 0.1 0.00065 19.4 0.1 1.7 1 1 1 2 2 2 1 Dephospho-CoA kinase APS_kinase PF01583.20 AIC16781.1 - 0.00091 19.1 0.0 0.0036 17.2 0.0 1.9 2 0 0 2 2 2 1 Adenylylsulphate kinase Zeta_toxin PF06414.12 AIC16781.1 - 0.0011 18.2 0.0 0.0032 16.8 0.0 1.8 2 0 0 2 2 2 1 Zeta toxin ABC_tran PF00005.27 AIC16781.1 - 0.0012 19.4 0.0 0.0031 18.0 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_22 PF13401.6 AIC16781.1 - 0.0041 17.4 0.1 0.007 16.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain MeaB PF03308.16 AIC16781.1 - 0.01 14.8 0.1 0.019 13.9 0.1 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 AIC16781.1 - 0.013 15.9 0.2 0.023 15.1 0.2 1.6 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 AIC16781.1 - 0.02 14.1 0.0 0.028 13.6 0.0 1.4 1 1 0 1 1 1 0 NB-ARC domain NTPase_1 PF03266.15 AIC16781.1 - 0.029 14.3 0.2 0.057 13.3 0.1 1.7 1 1 0 1 1 1 0 NTPase KTI12 PF08433.10 AIC16781.1 - 0.038 13.5 0.0 0.077 12.4 0.0 1.5 2 0 0 2 2 2 0 Chromatin associated protein KTI12 AAA_30 PF13604.6 AIC16781.1 - 0.056 13.2 0.1 0.17 11.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 AIC16781.1 - 0.077 13.1 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 Sigma-54 interaction domain UPF0180 PF03698.13 AIC16781.1 - 0.095 12.9 0.0 0.26 11.5 0.0 1.7 2 0 0 2 2 1 0 Uncharacterised protein family (UPF0180) AAA_5 PF07728.14 AIC16781.1 - 0.095 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PGM_PMM_II PF02879.16 AIC16781.1 - 0.1 13.2 0.0 0.23 12.1 0.0 1.7 2 0 0 2 2 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Torsin PF06309.11 AIC16781.1 - 0.17 12.0 0.0 0.5 10.5 0.0 1.8 1 1 1 2 2 2 0 Torsin Rhodanese PF00581.20 AIC16782.1 - 2.1e-33 115.0 0.0 6.6e-16 58.8 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain SBP_bac_5 PF00496.22 AIC16782.1 - 0.035 13.1 0.1 0.052 12.5 0.1 1.3 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle NIR_SIR PF01077.22 AIC16783.1 - 7.8e-44 149.0 0.0 6.4e-33 113.5 0.0 2.7 3 0 0 3 3 3 2 Nitrite and sulphite reductase 4Fe-4S domain NIR_SIR_ferr PF03460.17 AIC16783.1 - 1.4e-33 114.6 0.1 1.2e-18 66.7 0.0 2.5 2 0 0 2 2 2 2 Nitrite/Sulfite reductase ferredoxin-like half domain Glyoxalase PF00903.25 AIC16784.1 - 2.6e-06 27.7 0.0 9.8e-06 25.8 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 AIC16784.1 - 0.00022 22.0 0.0 0.00045 21.0 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Ribosomal_L2_C PF03947.18 AIC16785.1 - 6.4e-37 126.6 3.8 1.1e-36 125.9 3.8 1.4 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 AIC16785.1 - 2.2e-11 43.6 0.1 6.1e-11 42.1 0.1 1.8 1 0 0 1 1 1 1 Ribosomal Proteins L2, RNA binding domain GGA_N-GAT PF18308.1 AIC16786.1 - 0.038 13.6 0.1 0.082 12.5 0.1 1.5 1 0 0 1 1 1 0 GGA N-GAT domain HhH-GPD PF00730.25 AIC16787.1 - 5e-18 65.5 0.0 6.5e-18 65.2 0.0 1.1 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 AIC16787.1 - 0.13 12.2 0.0 0.43 10.6 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif PAC2 PF09754.9 AIC16788.1 - 2.3e-27 96.4 0.0 2.7e-27 96.2 0.0 1.0 1 0 0 1 1 1 1 PAC2 family Choline_kinase PF01633.20 AIC16789.1 - 0.19 11.3 0.0 1.3 8.6 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase tRNA_NucTransf2 PF09249.11 AIC16790.1 - 4.4e-36 123.6 0.0 9.5e-36 122.5 0.0 1.6 1 0 0 1 1 1 1 tRNA nucleotidyltransferase, second domain NTP_transf_2 PF01909.23 AIC16790.1 - 2.9e-11 43.5 0.0 5.7e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain SMODS PF18144.1 AIC16790.1 - 1e-05 25.8 0.0 2.2e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Polbeta PF18765.1 AIC16790.1 - 0.0022 18.0 0.0 0.0044 17.1 0.0 1.4 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase LigT_PEase PF02834.16 AIC16791.1 - 7.9e-24 83.7 0.1 4.4e-14 52.4 0.0 2.1 2 0 0 2 2 2 2 LigT like Phosphoesterase 2_5_RNA_ligase2 PF13563.6 AIC16791.1 - 3.6e-11 43.2 0.0 4.4e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily AKAP7_NLS PF10469.9 AIC16791.1 - 1.9e-07 31.2 0.0 3.5e-07 30.3 0.0 1.4 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain DS PF01916.17 AIC16793.1 - 8.8e-77 258.2 0.0 1.1e-76 257.9 0.0 1.1 1 0 0 1 1 1 1 Deoxyhypusine synthase SelP_N PF04592.14 AIC16793.1 - 1.1 8.5 10.6 1.8 7.9 10.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DS PF01916.17 AIC16794.1 - 4.9e-93 311.5 0.0 5.6e-93 311.3 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase SnoaL_2 PF12680.7 AIC16795.1 - 5.3e-09 36.6 0.0 6.7e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 SnoaL-like domain DUF4440 PF14534.6 AIC16795.1 - 2.3e-05 24.8 0.0 3.1e-05 24.3 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4440) SnoaL_3 PF13474.6 AIC16795.1 - 3.1e-05 24.2 0.0 6.2e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 SnoaL-like domain DUF1348 PF07080.11 AIC16795.1 - 0.017 15.0 0.3 0.04 13.8 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1348) CUB PF00431.20 AIC16795.1 - 0.047 14.0 0.0 0.065 13.6 0.0 1.2 1 0 0 1 1 1 0 CUB domain SnoaL_4 PF13577.6 AIC16795.1 - 0.11 12.7 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 SnoaL-like domain Inositol_P PF00459.25 AIC16796.1 - 1.3e-46 159.3 0.0 1.5e-46 159.1 0.0 1.0 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 AIC16796.1 - 0.0022 17.5 0.0 0.0034 16.9 0.0 1.3 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Pro_isomerase PF00160.21 AIC16797.1 - 7e-49 166.1 0.1 1.2e-48 165.4 0.1 1.3 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD STT3 PF02516.14 AIC16797.1 - 2.5e-38 132.2 30.6 5.1e-38 131.2 30.6 1.5 1 1 0 1 1 1 1 Oligosaccharyl transferase STT3 subunit PMT_2 PF13231.6 AIC16797.1 - 9.2e-07 29.2 16.2 9.2e-07 29.2 16.2 3.5 3 2 2 5 5 5 1 Dolichyl-phosphate-mannose-protein mannosyltransferase Lactamase_B_3 PF13483.6 AIC16798.1 - 1e-30 106.8 0.8 1.3e-30 106.5 0.8 1.1 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 AIC16798.1 - 1.3e-15 57.4 0.7 1.8e-15 57.0 0.7 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B PF00753.27 AIC16798.1 - 0.026 14.5 2.3 0.074 13.0 2.3 1.8 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily XdhC_C PF13478.6 AIC16798.1 - 0.029 14.9 0.4 0.14 12.6 0.1 2.0 1 1 1 2 2 2 0 XdhC Rossmann domain PIN_9 PF18477.1 AIC16799.1 - 6.6e-22 78.0 1.7 7.3e-22 77.9 1.7 1.0 1 0 0 1 1 1 1 PIN like domain DUF188 PF02639.14 AIC16799.1 - 0.015 14.9 0.5 0.021 14.5 0.5 1.1 1 0 0 1 1 1 0 Uncharacterized BCR, YaiI/YqxD family COG1671 DUF5615 PF18480.1 AIC16799.1 - 0.017 14.8 0.1 0.038 13.7 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF5615) PIN_4 PF13638.6 AIC16799.1 - 0.06 13.6 0.4 0.27 11.5 0.4 2.0 1 1 0 1 1 1 0 PIN domain GTP_EFTU PF00009.27 AIC16800.1 - 4.3e-30 104.7 0.2 2.9e-29 102.0 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain eIF2_C PF09173.11 AIC16800.1 - 4.8e-28 97.2 0.1 1.2e-27 96.0 0.1 1.7 1 0 0 1 1 1 1 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 AIC16800.1 - 5.7e-05 23.4 0.6 0.00014 22.2 0.6 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RsgA_GTPase PF03193.16 AIC16800.1 - 0.00032 20.6 0.6 0.0062 16.4 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 AIC16800.1 - 0.0027 17.8 0.0 0.005 16.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase MMR_HSR1_Xtn PF16897.5 AIC16800.1 - 0.01 15.8 0.2 0.022 14.8 0.2 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain Ribosomal_S6e PF01092.19 AIC16801.1 - 9.1e-24 83.8 0.3 1.1e-23 83.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal protein S6e HTH_23 PF13384.6 AIC16803.1 - 7.5e-09 35.1 0.1 2.2e-08 33.7 0.1 1.8 1 0 0 1 1 1 1 Homeodomain-like domain HTH_28 PF13518.6 AIC16803.1 - 1.4e-06 28.3 0.1 4.3e-06 26.8 0.1 1.8 2 0 0 2 2 1 1 Helix-turn-helix domain HTH_38 PF13936.6 AIC16803.1 - 1.8e-06 27.6 0.1 3.5e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain Sigma70_r4_2 PF08281.12 AIC16803.1 - 6.1e-06 25.8 0.4 1.6e-05 24.5 0.4 1.7 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_40 PF14493.6 AIC16803.1 - 0.00011 22.5 0.2 0.00079 19.8 0.2 2.1 1 1 0 1 1 1 1 Helix-turn-helix domain GerE PF00196.19 AIC16803.1 - 0.00057 19.4 3.5 0.00098 18.6 0.1 2.6 2 1 1 3 3 3 1 Bacterial regulatory proteins, luxR family Arg_repressor PF01316.21 AIC16803.1 - 0.00091 18.9 0.1 0.0018 18.0 0.1 1.5 1 0 0 1 1 1 1 Arginine repressor, DNA binding domain Sigma70_r4 PF04545.16 AIC16803.1 - 0.00093 18.7 0.1 0.0017 17.8 0.1 1.4 1 0 0 1 1 1 1 Sigma-70, region 4 Sigma70_ECF PF07638.11 AIC16803.1 - 0.001 19.0 0.0 0.0018 18.2 0.0 1.3 1 0 0 1 1 1 1 ECF sigma factor HTH_29 PF13551.6 AIC16803.1 - 0.0011 18.9 0.0 0.0025 17.8 0.0 1.6 1 0 0 1 1 1 1 Winged helix-turn helix Terminase_5 PF06056.12 AIC16803.1 - 0.0028 17.5 0.0 0.0067 16.3 0.0 1.8 1 0 0 1 1 1 1 Putative ATPase subunit of terminase (gpP-like) Trp_repressor PF01371.19 AIC16803.1 - 0.0038 17.3 0.1 0.0067 16.5 0.1 1.4 1 0 0 1 1 1 1 Trp repressor protein HTH_5 PF01022.20 AIC16803.1 - 0.0041 17.0 0.0 0.012 15.5 0.0 1.8 1 1 1 2 2 2 1 Bacterial regulatory protein, arsR family HTH_11 PF08279.12 AIC16803.1 - 0.0061 16.5 0.2 0.011 15.7 0.2 1.5 1 0 0 1 1 1 1 HTH domain HTH_24 PF13412.6 AIC16803.1 - 0.011 15.3 0.1 0.03 13.9 0.1 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding XH PF03469.14 AIC16803.1 - 0.014 15.3 0.6 0.021 14.8 0.6 1.3 1 0 0 1 1 1 0 XH domain MarR PF01047.22 AIC16803.1 - 0.017 15.0 0.0 0.035 14.0 0.0 1.5 1 0 0 1 1 1 0 MarR family CENP-B_N PF04218.13 AIC16803.1 - 0.018 14.7 0.1 0.034 13.8 0.1 1.4 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain HTH_3 PF01381.22 AIC16803.1 - 0.023 14.8 0.3 0.023 14.8 0.3 1.7 2 0 0 2 2 2 0 Helix-turn-helix MarR_2 PF12802.7 AIC16803.1 - 0.037 13.9 0.0 0.064 13.2 0.0 1.4 1 0 0 1 1 1 0 MarR family HTH_31 PF13560.6 AIC16803.1 - 0.039 14.3 0.1 0.06 13.7 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_Crp_2 PF13545.6 AIC16803.1 - 0.041 13.9 0.1 0.062 13.3 0.1 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain HTH_7 PF02796.15 AIC16803.1 - 0.048 13.8 0.0 0.092 12.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain of resolvase Cro PF09048.10 AIC16803.1 - 0.052 13.6 0.3 0.31 11.1 0.1 2.1 2 0 0 2 2 2 0 Cro RepB PF07506.11 AIC16803.1 - 0.061 13.4 0.4 0.17 11.9 0.4 1.8 1 1 0 1 1 1 0 RepB plasmid partitioning protein ESAG1 PF03238.13 AIC16803.1 - 0.067 12.6 0.2 0.091 12.2 0.2 1.2 1 0 0 1 1 1 0 ESAG protein YdaS_antitoxin PF15943.5 AIC16803.1 - 0.082 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT HTH_IclR PF09339.10 AIC16803.1 - 0.088 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 IclR helix-turn-helix domain Band_3_cyto PF07565.13 AIC16804.1 - 1 9.1 5.8 2.1 8.1 5.8 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain TFIIE_alpha PF02002.17 AIC16806.1 - 0.012 15.5 0.0 0.014 15.2 0.0 1.1 1 0 0 1 1 1 0 TFIIE alpha subunit HTH_45 PF14947.6 AIC16806.1 - 0.062 13.3 0.1 0.09 12.8 0.1 1.3 1 0 0 1 1 1 0 Winged helix-turn-helix PP_kinase_C_1 PF17941.1 AIC16806.1 - 0.062 12.8 0.0 0.12 11.9 0.0 1.5 1 1 1 2 2 2 0 Polyphosphate kinase C-terminal domain 1 HTH_Crp_2 PF13545.6 AIC16806.1 - 0.14 12.2 0.0 0.19 11.7 0.0 1.4 1 1 0 1 1 1 0 Crp-like helix-turn-helix domain TF_Zn_Ribbon PF08271.12 AIC16807.1 - 9.3e-05 21.9 1.1 0.00012 21.5 1.1 1.3 1 0 0 1 1 1 1 TFIIB zinc-binding zf-ribbon_3 PF13248.6 AIC16807.1 - 0.0028 17.0 5.3 0.042 13.3 5.4 2.1 1 1 0 1 1 1 1 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 AIC16807.1 - 0.003 17.2 1.2 0.0046 16.6 1.2 1.3 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Prok-RING_1 PF14446.6 AIC16807.1 - 0.0034 17.3 1.2 0.0046 16.8 1.2 1.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zinc_ribbon_4 PF13717.6 AIC16807.1 - 0.0063 16.4 2.4 0.035 14.0 2.4 1.9 1 1 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_2 PF13240.6 AIC16807.1 - 0.0095 15.6 4.6 0.023 14.4 4.6 1.6 1 1 0 1 1 1 1 zinc-ribbon domain HypA PF01155.19 AIC16807.1 - 0.011 15.7 0.3 0.012 15.6 0.3 1.2 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lar_restr_allev PF14354.6 AIC16807.1 - 0.014 15.8 2.7 0.09 13.2 2.7 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar Ribosomal_S27e PF01667.17 AIC16807.1 - 0.015 15.0 0.5 0.02 14.6 0.5 1.2 1 0 0 1 1 1 0 Ribosomal protein S27 CpXC PF14353.6 AIC16807.1 - 0.015 15.3 2.0 0.49 10.5 2.0 2.1 1 1 0 1 1 1 0 CpXC protein DNA_ligase_ZBD PF03119.16 AIC16807.1 - 0.016 15.2 0.2 0.027 14.5 0.2 1.4 1 0 0 1 1 1 0 NAD-dependent DNA ligase C4 zinc finger domain OrfB_Zn_ribbon PF07282.11 AIC16807.1 - 0.017 15.0 2.0 0.023 14.6 1.7 1.3 1 1 0 1 1 1 0 Putative transposase DNA-binding domain DZR PF12773.7 AIC16807.1 - 0.021 14.9 1.8 0.039 14.0 1.8 1.4 1 1 0 1 1 1 0 Double zinc ribbon Elf1 PF05129.13 AIC16807.1 - 0.053 13.6 1.3 0.1 12.6 1.2 1.6 1 1 0 1 1 1 0 Transcription elongation factor Elf1 like YyzF PF14116.6 AIC16807.1 - 0.062 13.3 4.4 0.1 12.6 0.4 2.2 1 1 1 2 2 2 0 YyzF-like protein DUF2225 PF09986.9 AIC16807.1 - 0.081 12.6 1.3 0.18 11.5 0.0 1.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) zf-H2C2_2 PF13465.6 AIC16807.1 - 0.086 13.3 4.8 5.2 7.7 0.1 2.2 2 0 0 2 2 2 0 Zinc-finger double domain UPF0547 PF10571.9 AIC16807.1 - 0.092 12.8 3.0 2.9 8.1 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zinc_ribbon_13 PF09855.9 AIC16807.1 - 0.11 12.7 5.8 0.98 9.6 0.4 2.2 1 1 1 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-ISL3 PF14690.6 AIC16807.1 - 0.27 11.9 3.0 2.1 9.1 3.0 2.0 1 1 0 1 1 1 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zinc_ribbon_5 PF13719.6 AIC16807.1 - 0.48 10.2 4.4 0.86 9.4 4.4 1.4 1 1 0 1 1 1 0 zinc-ribbon domain SpdB PF05122.13 AIC16807.1 - 0.9 9.7 3.6 1.2 9.3 1.1 2.1 1 1 1 2 2 2 0 Mobile element transfer protein Zn-ribbon_8 PF09723.10 AIC16807.1 - 2.5 8.3 6.7 1.8 8.8 1.1 2.2 1 1 0 2 2 2 0 Zinc ribbon domain DUF899 PF05988.12 AIC16808.1 - 7.6e-96 319.7 1.1 8.8e-96 319.6 1.1 1.0 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF899) AhpC-TSA PF00578.21 AIC16808.1 - 2.6e-05 24.2 0.0 3.8e-05 23.6 0.0 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC16808.1 - 0.11 12.2 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Redoxin DSPc PF00782.20 AIC16810.1 - 2.6e-17 62.9 0.0 3.2e-17 62.6 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 AIC16810.1 - 4.9e-07 29.5 0.0 6.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 AIC16810.1 - 6.9e-07 29.5 0.0 1e-06 28.9 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 AIC16810.1 - 4.2e-06 26.9 0.0 5.8e-06 26.4 0.0 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 AIC16810.1 - 0.0034 17.0 0.0 0.007 16.0 0.0 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family Rieske PF00355.26 AIC16812.1 - 1.4e-17 63.4 0.0 1.6e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIC16812.1 - 9.1e-08 32.0 0.0 1.3e-07 31.4 0.0 1.3 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain MDD_C PF18376.1 AIC16814.1 - 0.063 13.0 0.1 0.14 11.9 0.0 1.5 2 0 0 2 2 2 0 Mevalonate 5-diphosphate decarboxylase C-terminal domain THF_DHG_CYH_C PF02882.19 AIC16814.1 - 0.13 11.6 0.0 0.16 11.2 0.0 1.3 1 1 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain tRNA-synt_1 PF00133.22 AIC16815.1 - 1.3e-131 439.8 0.0 1.8e-131 439.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 AIC16815.1 - 1.2e-27 96.8 0.2 4.4e-27 94.9 0.0 2.0 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 AIC16815.1 - 3.6e-21 75.4 0.9 6.3e-09 35.1 0.0 4.1 3 1 0 3 3 3 3 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 AIC16815.1 - 1.6e-05 24.4 0.0 0.00011 21.6 0.0 2.1 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 AIC16815.1 - 0.00061 18.8 0.0 0.0015 17.5 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (K) DZR PF12773.7 AIC16815.1 - 0.1 12.7 0.4 12 6.0 0.1 2.5 2 0 0 2 2 2 0 Double zinc ribbon Erp_C PF06780.11 AIC16815.1 - 0.11 12.5 0.0 10 6.1 0.0 2.5 2 0 0 2 2 2 0 Erp protein C-terminus Zn-ribbon_8 PF09723.10 AIC16815.1 - 0.13 12.4 1.6 2.4 8.3 0.1 3.1 3 0 0 3 3 3 0 Zinc ribbon domain DEP PF00610.21 AIC16816.1 - 0.075 13.1 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PDGLE PF13190.6 AIC16816.1 - 0.13 12.2 0.2 0.18 11.7 0.2 1.4 1 1 0 1 1 1 0 PDGLE domain SseC PF04888.12 AIC16817.1 - 0.0042 16.7 0.3 0.0052 16.4 0.3 1.1 1 0 0 1 1 1 1 Secretion system effector C (SseC) like family DUF4199 PF13858.6 AIC16817.1 - 0.0087 16.5 0.1 0.0087 16.5 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) DUF192 PF02643.15 AIC16818.1 - 1.5e-28 98.8 0.0 2.1e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized ACR, COG1430 TrmB PF01978.19 AIC16819.1 - 1.1e-15 57.3 1.0 2.1e-15 56.4 0.3 1.8 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 AIC16819.1 - 0.091 12.7 0.0 0.32 10.9 0.0 1.9 1 0 0 1 1 1 0 MarR family Apolipoprotein PF01442.18 AIC16820.1 - 0.032 14.1 0.2 0.05 13.5 0.2 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Cortex-I_coil PF09304.10 AIC16820.1 - 0.068 13.4 1.1 0.15 12.3 1.1 1.5 1 0 0 1 1 1 0 Cortexillin I, coiled coil Herpes_UL6 PF01763.16 AIC16820.1 - 0.071 11.6 0.0 0.09 11.3 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like eIF_4EBP PF05456.11 AIC16821.1 - 0.15 12.0 0.0 0.22 11.5 0.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) AAA PF00004.29 AIC16822.1 - 9.1e-37 126.4 0.0 4e-36 124.4 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 AIC16822.1 - 7.3e-07 29.2 3.5 1.4e-06 28.3 3.5 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_lid_3 PF17862.1 AIC16822.1 - 2.5e-06 27.2 0.0 6.6e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 AIC16822.1 - 4.3e-05 23.7 0.1 0.00013 22.1 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 AIC16822.1 - 5.5e-05 23.6 0.0 0.0016 18.9 0.0 2.5 1 1 1 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 AIC16822.1 - 0.00019 21.7 0.1 0.035 14.4 0.1 3.1 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 AIC16822.1 - 0.00026 20.8 0.0 0.00054 19.7 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Vps4_C PF09336.10 AIC16822.1 - 0.00052 20.0 0.1 0.0047 16.9 0.0 2.2 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RNA_helicase PF00910.22 AIC16822.1 - 0.00069 20.0 0.1 0.12 12.8 0.0 2.7 2 1 0 2 2 2 1 RNA helicase AAA_25 PF13481.6 AIC16822.1 - 0.0021 17.6 0.0 0.038 13.6 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 AIC16822.1 - 0.0026 17.8 0.0 0.038 14.0 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 AIC16822.1 - 0.0032 17.5 0.0 0.019 15.0 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_24 PF13479.6 AIC16822.1 - 0.017 14.9 0.0 0.051 13.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 AIC16822.1 - 0.018 14.8 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 AIC16822.1 - 0.024 14.0 0.0 0.05 13.0 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 AIC16822.1 - 0.025 14.7 0.0 0.041 14.0 0.0 1.5 1 1 0 1 1 1 0 AAA domain TIP49 PF06068.13 AIC16822.1 - 0.029 13.6 0.0 0.073 12.3 0.0 1.6 1 1 1 2 2 2 0 TIP49 P-loop domain AAA_18 PF13238.6 AIC16822.1 - 0.03 14.9 0.0 0.14 12.7 0.0 2.2 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 AIC16822.1 - 0.048 12.9 0.0 0.19 11.0 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin KAP_NTPase PF07693.14 AIC16822.1 - 0.071 12.3 0.0 0.9 8.7 0.0 2.0 1 1 1 2 2 2 0 KAP family P-loop domain ATPase PF06745.13 AIC16822.1 - 0.11 11.8 0.0 1.4 8.2 0.0 2.4 1 1 1 2 2 2 0 KaiC ATPase_2 PF01637.18 AIC16822.1 - 0.14 12.0 0.1 1.9 8.3 0.0 2.4 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea PhoH PF02562.16 AIC16822.1 - 0.18 11.2 0.1 0.35 10.3 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein CHB_HEX_C_1 PF13290.6 AIC16823.1 - 2e-31 107.8 35.0 6.3e-17 61.4 4.9 5.1 5 0 0 5 5 5 2 Chitobiase/beta-hexosaminidase C-terminal domain Fn3_assoc PF13287.6 AIC16823.1 - 6.1e-28 96.7 23.7 7.1e-16 58.1 2.7 3.7 3 0 0 3 3 3 2 Fn3 associated HYR PF02494.16 AIC16823.1 - 3e-13 49.9 18.8 4.4e-07 30.1 1.0 4.3 4 2 1 5 5 5 2 HYR domain Polysacc_deac_1 PF01522.21 AIC16823.1 - 1.3e-11 44.5 0.3 4.3e-11 42.8 0.0 2.0 3 0 0 3 3 3 1 Polysaccharide deacetylase CHB_HEX_C PF03174.13 AIC16823.1 - 4.8e-07 29.7 0.9 0.018 15.0 0.0 3.4 3 0 0 3 3 3 2 Chitobiase/beta-hexosaminidase C-terminal domain DUF2334 PF10096.9 AIC16823.1 - 4.2e-05 23.3 0.0 7.5e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2334) Glyco_hydro_57 PF03065.15 AIC16823.1 - 0.011 15.0 0.0 0.016 14.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 57 Y_Y_Y PF07495.13 AIC16823.1 - 0.026 14.4 0.1 12 6.0 0.0 2.7 2 0 0 2 2 2 0 Y_Y_Y domain ASH PF15780.5 AIC16823.1 - 0.063 13.5 1.5 0.17 12.1 0.3 2.4 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin BsuPI PF12690.7 AIC16823.1 - 0.07 13.2 1.1 4.2 7.4 0.0 3.4 2 1 1 3 3 3 0 Intracellular proteinase inhibitor CARDB PF07705.11 AIC16823.1 - 0.85 9.9 19.2 0.35 11.1 1.2 4.6 3 1 1 4 4 4 0 CARDB PA14 PF07691.12 AIC16823.1 - 3.1 7.6 7.3 0.49 10.2 0.1 3.2 5 0 0 5 5 5 0 PA14 domain Pyrophosphatase PF00719.19 AIC16824.1 - 5.7e-58 195.3 1.1 6.5e-58 195.1 1.1 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase InPase PF18823.1 AIC16824.1 - 0.0045 16.7 0.3 0.039 13.7 0.0 2.2 2 1 0 2 2 2 1 Inorganic Pyrophosphatase DUF5622 PF18533.1 AIC16824.1 - 0.14 12.3 3.7 9.9 6.4 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5622) Hydrolase_3 PF08282.12 AIC16826.1 - 8.6e-25 87.9 0.0 7.1e-17 62.0 0.0 2.1 1 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 AIC16826.1 - 3e-06 27.7 3.0 0.00068 20.0 0.0 2.8 3 1 1 4 4 4 2 haloacid dehalogenase-like hydrolase S6PP PF05116.13 AIC16826.1 - 0.00011 21.9 0.0 0.18 11.3 0.0 2.1 2 0 0 2 2 2 2 Sucrose-6F-phosphate phosphohydrolase HAD PF12710.7 AIC16826.1 - 0.00018 22.0 0.1 0.0063 16.9 0.0 2.4 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 AIC16826.1 - 0.027 14.6 0.0 0.054 13.6 0.0 1.5 1 0 0 1 1 1 0 HAD-hyrolase-like HAD_2 PF13419.6 AIC16826.1 - 0.058 13.5 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Acid_phosphat_B PF03767.14 AIC16826.1 - 0.081 12.5 0.0 2.1 7.9 0.0 2.2 1 1 1 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) DALR_1 PF05746.15 AIC16827.1 - 2.6e-31 108.3 3.1 2.6e-31 108.3 3.1 1.8 2 0 0 2 2 2 1 DALR anticodon binding domain tRNA-synt_1d PF00750.19 AIC16827.1 - 4.5e-30 104.8 2.1 1e-20 74.0 0.2 2.6 2 1 0 2 2 2 2 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 AIC16827.1 - 5.4e-16 59.0 0.1 2.8e-15 56.7 0.1 2.3 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA-synt_1g PF09334.11 AIC16827.1 - 0.029 13.1 0.1 0.049 12.4 0.1 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (M) TetR_C_18 PF17923.1 AIC16827.1 - 0.036 14.6 0.1 0.12 12.9 0.1 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain tRNA-synt_1e PF01406.19 AIC16827.1 - 0.13 11.6 0.3 0.26 10.6 0.3 1.4 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain Lir1 PF07207.11 AIC16829.1 - 0.23 11.7 0.8 0.37 11.0 0.0 1.7 2 0 0 2 2 2 0 Light regulated protein Lir1 GCD14 PF08704.10 AIC16830.1 - 5e-36 124.6 0.0 2.3e-33 115.9 0.0 2.1 1 1 1 2 2 2 2 tRNA methyltransferase complex GCD14 subunit PCMT PF01135.19 AIC16830.1 - 2.5e-09 37.2 0.0 3.6e-09 36.7 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 AIC16830.1 - 3.4e-08 33.4 0.0 5.2e-08 32.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC16830.1 - 2e-06 27.3 0.0 3e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 AIC16830.1 - 3.2e-05 24.5 0.0 8.2e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_3 PF01596.17 AIC16830.1 - 5.3e-05 22.5 0.0 8.4e-05 21.8 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 AIC16830.1 - 0.0015 19.5 0.0 0.0027 18.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain GCD14_N PF14801.6 AIC16830.1 - 0.0017 18.2 0.1 0.0033 17.2 0.1 1.5 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Fibrillarin PF01269.17 AIC16830.1 - 0.0018 17.4 0.0 0.003 16.7 0.0 1.4 1 0 0 1 1 1 1 Fibrillarin Methyltransf_18 PF12847.7 AIC16830.1 - 0.0033 17.4 0.0 0.0051 16.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC16830.1 - 0.0048 17.5 0.0 0.0091 16.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC16830.1 - 0.01 16.6 0.0 0.023 15.5 0.0 1.6 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 AIC16830.1 - 0.015 14.7 0.0 0.02 14.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF938 PF06080.12 AIC16830.1 - 0.074 12.8 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF938) MTS PF05175.14 AIC16830.1 - 0.15 11.6 0.0 0.33 10.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain RRM_5 PF13893.6 AIC16831.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4367 PF14285.6 AIC16832.1 - 0.0076 16.7 0.0 0.0083 16.6 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4367) Copper-bind PF00127.20 AIC16833.1 - 0.00034 21.0 0.0 0.00091 19.6 0.0 1.7 2 0 0 2 2 2 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC16833.1 - 0.097 12.8 0.0 0.4 10.8 0.0 2.0 2 1 0 2 2 2 0 Cupredoxin-like domain Phage_GP20 PF06810.11 AIC16834.1 - 0.00059 19.7 0.7 0.00059 19.7 0.7 1.9 2 0 0 2 2 2 1 Phage minor structural protein GP20 DDE_Tnp_IS240 PF13610.6 AIC16837.1 - 2.3e-10 40.8 0.1 3.7e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 DDE domain N_methyl PF07963.12 AIC16840.1 - 0.012 15.2 0.2 0.012 15.2 0.2 3.2 3 0 0 3 3 3 0 Prokaryotic N-terminal methylation motif DUF5094 PF17015.5 AIC16840.1 - 0.089 12.9 0.1 0.13 12.3 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) Ndc1_Nup PF09531.10 AIC16840.1 - 0.19 10.4 18.7 0.0036 16.1 11.8 1.5 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup GRAM PF02893.20 AIC16841.1 - 0.00069 19.5 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 GRAM domain DUF349 PF03993.12 AIC16841.1 - 0.026 14.8 1.6 7.4 6.9 0.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Vps36_ESCRT-II PF11605.8 AIC16841.1 - 0.088 13.0 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting protein 36 Vps36 ATPase_2 PF01637.18 AIC16842.1 - 2.3e-13 50.6 0.0 4.8e-13 49.6 0.0 1.5 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 AIC16842.1 - 7.3e-11 42.2 0.0 4e-06 26.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 AIC16842.1 - 1.5e-10 41.5 0.9 2.1e-09 37.8 0.2 2.6 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 AIC16842.1 - 6.2e-09 36.5 0.0 1.7e-08 35.1 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain AAA_35 PF14516.6 AIC16842.1 - 0.0002 20.3 0.0 0.00062 18.7 0.0 1.9 1 1 0 1 1 1 1 AAA-like domain TniB PF05621.11 AIC16842.1 - 0.0012 18.3 0.0 0.24 10.8 0.0 2.5 2 0 0 2 2 2 1 Bacterial TniB protein HTH_45 PF14947.6 AIC16842.1 - 0.0083 16.1 0.0 0.038 14.0 0.1 2.1 2 0 0 2 2 2 1 Winged helix-turn-helix AAA-ATPase_like PF09820.9 AIC16842.1 - 0.01 15.2 0.1 0.026 13.9 0.0 1.7 2 0 0 2 2 2 0 Predicted AAA-ATPase TrmB PF01978.19 AIC16842.1 - 0.012 15.5 0.1 0.036 13.9 0.1 1.8 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_27 PF13463.6 AIC16842.1 - 0.015 15.8 0.1 0.039 14.5 0.1 1.7 1 0 0 1 1 1 0 Winged helix DNA-binding domain NTPase_1 PF03266.15 AIC16842.1 - 0.022 14.7 0.1 0.14 12.1 0.0 2.2 1 1 1 2 2 2 0 NTPase HTH_5 PF01022.20 AIC16842.1 - 0.046 13.6 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family AAA PF00004.29 AIC16842.1 - 0.092 13.2 0.1 0.53 10.7 0.1 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Colicin_Ia PF11504.8 AIC16842.1 - 0.14 12.3 0.1 0.8 9.9 0.0 2.1 2 0 0 2 2 2 0 Colicin Ia Cas_Cas6 PF01881.16 AIC16843.1 - 2.2e-15 57.5 0.0 3.9e-15 56.7 0.0 1.4 1 0 0 1 1 1 1 CRISPR associated protein Cas6 HD_6 PF18019.1 AIC16844.1 - 1e-10 42.1 0.0 1.5e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 HD domain DEAD PF00270.29 AIC16844.1 - 3e-07 30.4 0.0 1.2e-06 28.4 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 AIC16844.1 - 5.5e-06 26.7 0.7 2.9e-05 24.4 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_19 PF13245.6 AIC16844.1 - 5.4e-05 23.6 0.6 0.12 12.7 0.0 3.6 4 1 0 4 4 4 2 AAA domain HD PF01966.22 AIC16844.1 - 0.00043 20.5 0.9 0.0042 17.3 0.0 2.4 2 0 0 2 2 2 1 HD domain Cas_Cas5d PF09704.10 AIC16845.1 - 6.6e-10 39.2 0.0 7.9e-10 39.0 0.0 1.1 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Cas5) RAMPs PF03787.15 AIC16845.1 - 0.11 12.5 0.3 0.15 12.1 0.3 1.5 1 1 0 1 1 1 0 RAMP superfamily DevR PF01905.16 AIC16846.1 - 9.2e-28 97.0 0.0 1.3e-27 96.6 0.0 1.2 1 0 0 1 1 1 1 CRISPR-associated negative auto-regulator DevR/Csa2 Cas_CXXC_CXXC PF09706.10 AIC16847.1 - 3.3e-05 24.0 0.8 8.6e-05 22.7 0.8 1.8 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_CXXC_CXXC) Cas_Cas6 PF01881.16 AIC16848.1 - 1.9e-27 96.7 0.0 1.2e-26 94.0 0.0 1.8 2 0 0 2 2 2 1 CRISPR associated protein Cas6 CRISPR_Cas6 PF10040.9 AIC16848.1 - 0.0033 18.0 0.1 0.0043 17.7 0.1 1.4 1 1 0 1 1 1 1 CRISPR-associated endoribonuclease Cas6 Cas_Cas4 PF01930.17 AIC16849.1 - 7.4e-56 188.7 0.9 8.3e-56 188.6 0.9 1.0 1 0 0 1 1 1 1 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 AIC16849.1 - 8.7e-06 25.8 1.0 0.00028 20.9 0.2 2.0 2 0 0 2 2 2 2 PD-(D/E)XK nuclease superfamily PDDEXK_3 PF13366.6 AIC16849.1 - 0.0058 17.0 1.0 0.011 16.0 1.0 1.6 1 1 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Cas_Cas1 PF01867.16 AIC16850.1 - 1.9e-95 319.2 0.4 2.3e-95 319.0 0.4 1.0 1 0 0 1 1 1 1 CRISPR associated protein Cas1 CRISPR_Cas2 PF09827.9 AIC16851.1 - 3.8e-18 65.5 0.1 4.3e-18 65.3 0.1 1.1 1 0 0 1 1 1 1 CRISPR associated protein Cas2 Poxvirus PF06227.12 AIC16851.1 - 0.05 13.4 0.1 0.088 12.6 0.0 1.4 1 1 0 1 1 1 0 dsDNA Poxvirus NUDIX PF00293.28 AIC16852.1 - 3e-10 40.2 0.0 4.7e-10 39.6 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Usp PF00582.26 AIC16854.1 - 1.1e-08 35.6 0.0 1.2e-08 35.6 0.0 1.1 1 0 0 1 1 1 1 Universal stress protein family Usp PF00582.26 AIC16855.1 - 1.9e-17 64.1 0.1 2e-17 64.0 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family DUF4064 PF13273.6 AIC16856.1 - 0.048 13.9 0.1 0.058 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) zf-HIT PF04438.16 AIC16857.1 - 0.0034 17.2 7.3 0.0064 16.3 2.7 2.2 2 0 0 2 2 2 1 HIT zinc finger DUF35_N PF12172.8 AIC16857.1 - 0.015 15.2 4.6 0.078 12.9 1.5 2.2 2 0 0 2 2 2 0 Rubredoxin-like zinc ribbon domain (DUF35_N) DZR PF12773.7 AIC16857.1 - 0.019 15.0 6.7 0.097 12.7 6.7 2.0 1 1 0 1 1 1 0 Double zinc ribbon zf-WRNIP1_ubi PF18279.1 AIC16857.1 - 0.028 15.0 1.5 6.2 7.7 0.0 3.0 2 1 1 3 3 3 0 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-Sec23_Sec24 PF04810.15 AIC16857.1 - 0.034 14.2 5.5 0.034 14.2 5.5 1.8 2 1 0 2 2 2 0 Sec23/Sec24 zinc finger zinc-ribbons_6 PF07191.12 AIC16857.1 - 0.073 13.1 7.1 2.3 8.3 7.1 2.1 1 1 0 1 1 1 0 zinc-ribbons PolC_DP2 PF03833.13 AIC16857.1 - 0.091 10.6 3.3 0.083 10.8 3.3 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 NRDD PF13597.6 AIC16857.1 - 0.73 8.5 6.3 0.73 8.5 6.3 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase HypA PF01155.19 AIC16857.1 - 0.98 9.5 6.0 2.1 8.4 6.0 1.7 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ribosomal_L32p PF01783.23 AIC16857.1 - 5.2 7.4 8.0 2.4 8.5 0.8 2.1 1 1 1 2 2 2 0 Ribosomal L32p protein family zf_UBZ PF18439.1 AIC16857.1 - 9.6 5.9 7.7 11 5.7 0.7 2.8 1 1 2 3 3 3 0 Ubiquitin-Binding Zinc Finger DUF3341 PF11821.8 AIC16858.1 - 0.075 12.7 0.3 0.085 12.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) MTHFR PF02219.17 AIC16859.1 - 0.0066 15.8 0.0 0.012 14.9 0.0 1.5 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase Slp PF03843.13 AIC16859.1 - 0.18 11.2 0.0 0.27 10.6 0.0 1.2 1 0 0 1 1 1 0 Outer membrane lipoprotein Slp family DUF2387 PF09526.10 AIC16860.1 - 0.0024 18.0 0.2 0.0024 18.0 0.2 1.7 2 0 0 2 2 2 1 Probable metal-binding protein (DUF2387) Toxin_17 PF08086.11 AIC16860.1 - 0.093 13.0 2.0 0.093 13.0 2.0 2.0 3 0 0 3 3 3 0 Ergtoxin family zinc-ribbons_6 PF07191.12 AIC16860.1 - 2 8.4 10.6 13 5.8 10.6 2.2 1 1 0 1 1 1 0 zinc-ribbons DZR PF12773.7 AIC16860.1 - 2.3 8.3 12.0 8 6.6 3.1 2.8 1 1 1 2 2 2 0 Double zinc ribbon zf-HIT PF04438.16 AIC16860.1 - 6.4 6.8 14.7 11 5.9 0.2 3.8 3 1 0 3 3 3 0 HIT zinc finger Rep_fac-A_C PF08646.10 AIC16860.1 - 9.4 6.0 9.3 0.75 9.5 5.0 1.5 2 0 0 2 2 2 0 Replication factor-A C terminal domain ABC_tran PF00005.27 AIC16861.1 - 7.2e-32 110.8 0.0 1e-31 110.3 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC16861.1 - 3.2e-08 33.7 0.0 0.0013 18.6 0.0 2.2 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 AIC16861.1 - 4.2e-05 23.5 0.1 7.5e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 AIC16861.1 - 5.5e-05 22.7 2.2 0.015 14.7 0.0 2.6 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain AAA PF00004.29 AIC16861.1 - 0.00017 22.0 0.6 0.0022 18.4 0.6 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 AIC16861.1 - 0.00076 19.3 0.3 0.052 13.3 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_22 PF13401.6 AIC16861.1 - 0.0014 18.9 0.3 0.0036 17.6 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC16861.1 - 0.0014 19.0 0.1 0.0021 18.5 0.1 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_28 PF13521.6 AIC16861.1 - 0.0019 18.5 0.0 0.0046 17.2 0.0 1.7 2 0 0 2 2 1 1 AAA domain Rad17 PF03215.15 AIC16861.1 - 0.0034 17.3 0.0 0.0068 16.3 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_5 PF07728.14 AIC16861.1 - 0.0043 17.0 0.1 0.017 15.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 AIC16861.1 - 0.0048 17.4 0.0 0.0085 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain ABC_ATPase PF09818.9 AIC16861.1 - 0.0059 15.5 0.0 0.093 11.5 0.0 2.0 2 0 0 2 2 2 1 Predicted ATPase of the ABC class AAA_30 PF13604.6 AIC16861.1 - 0.0063 16.3 0.0 0.016 15.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AIC16861.1 - 0.0075 16.8 0.4 0.013 16.1 0.4 1.3 1 0 0 1 1 1 1 AAA domain AAA_15 PF13175.6 AIC16861.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 AIC16861.1 - 0.024 14.5 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 AIC16861.1 - 0.028 14.1 0.0 0.057 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 AIC16861.1 - 0.031 14.3 0.1 0.067 13.3 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase ATPase_2 PF01637.18 AIC16861.1 - 0.04 13.8 0.1 0.1 12.5 0.1 1.9 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 AIC16861.1 - 0.042 14.2 0.0 0.13 12.6 0.0 1.9 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 AIC16861.1 - 0.044 13.2 0.1 0.3 10.4 0.0 2.3 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 AIC16861.1 - 0.045 12.9 0.0 0.076 12.2 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 AIC16861.1 - 0.051 13.3 0.0 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 AIC16861.1 - 0.059 12.9 0.0 0.11 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 AIC16861.1 - 0.067 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 AIC16861.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_33 PF13671.6 AIC16861.1 - 0.1 12.8 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 AIC16861.1 - 0.11 12.4 0.1 0.56 10.1 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B PduV-EutP PF10662.9 AIC16861.1 - 0.12 12.2 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 AIC16861.1 - 0.12 11.8 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ATP-synt_ab PF00006.25 AIC16861.1 - 0.16 11.6 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Neurensin PF14927.6 AIC16862.1 - 0.01 15.5 0.1 0.62 9.8 0.1 2.2 2 0 0 2 2 2 0 Neurensin DUF4077 PF13295.6 AIC16862.1 - 0.016 15.2 0.6 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4077) DuoxA PF10204.9 AIC16862.1 - 0.031 13.3 0.2 0.056 12.4 0.1 1.5 2 0 0 2 2 2 0 Dual oxidase maturation factor Saf_2TM PF18303.1 AIC16862.1 - 0.095 12.3 0.6 0.16 11.5 0.2 1.6 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain DUF4115 PF13464.6 AIC16862.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4115) Gram_pos_anchor PF00746.21 AIC16862.1 - 0.31 11.0 0.2 0.31 11.0 0.2 2.4 2 0 0 2 2 2 0 LPXTG cell wall anchor motif CwsA PF10814.8 AIC16862.1 - 0.35 11.0 2.4 1.3 9.2 1.1 2.4 2 1 0 2 2 2 0 Cell wall synthesis protein CwsA Pterin_bind PF00809.22 AIC16863.1 - 5.5e-36 124.5 0.0 9.8e-36 123.6 0.0 1.4 1 0 0 1 1 1 1 Pterin binding enzyme B12-binding_2 PF02607.17 AIC16863.1 - 1.8e-24 86.0 0.9 4.9e-24 84.6 0.9 1.8 1 0 0 1 1 1 1 B12 binding domain Met_synt_B12 PF02965.17 AIC16863.1 - 3.9e-23 82.3 0.1 1.6e-22 80.3 0.1 2.0 1 1 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain B12-binding PF02310.19 AIC16863.1 - 2e-19 69.8 0.0 7.2e-19 68.0 0.0 2.0 2 0 0 2 2 2 1 B12 binding domain CdhD PF03599.16 AIC16863.1 - 0.0014 17.5 0.0 0.0026 16.5 0.0 1.4 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit adh_short PF00106.25 AIC16863.1 - 0.0071 15.8 0.3 0.041 13.3 0.0 2.2 2 0 0 2 2 2 1 short chain dehydrogenase Pterin_4a PF01329.19 AIC16864.1 - 8.6e-23 80.3 0.0 1.6e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase S-methyl_trans PF02574.16 AIC16867.1 - 8.8e-65 219.2 0.0 1e-64 219.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase Alba PF01918.21 AIC16868.1 - 0.0035 17.1 0.7 0.012 15.4 0.4 2.1 1 1 1 2 2 2 1 Alba PDE8 PF08629.10 AIC16868.1 - 6.3 6.9 6.4 1.1 9.3 2.1 1.9 2 0 0 2 2 2 0 PDE8 phosphodiesterase Pam17 PF08566.10 AIC16869.1 - 6.7 6.5 5.2 2.1 8.2 1.0 2.0 1 1 1 2 2 2 0 Mitochondrial import protein Pam17 LTD PF00932.19 AIC16870.1 - 0.0012 19.2 0.3 0.0052 17.1 0.0 2.2 1 1 0 2 2 2 1 Lamin Tail Domain NHL PF01436.21 AIC16871.1 - 4.4e-08 32.8 14.6 0.0071 16.3 0.0 6.3 6 1 1 7 7 7 2 NHL repeat Arylesterase PF01731.20 AIC16871.1 - 3.9e-05 23.8 1.8 1 9.6 0.0 4.7 3 1 1 4 4 4 2 Arylesterase SGL PF08450.12 AIC16871.1 - 0.0015 18.2 0.4 0.29 10.7 0.0 2.9 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region DUF1236 PF06823.12 AIC16871.1 - 0.016 15.1 6.1 0.14 12.1 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1236) Av_adeno_fibre PF06536.11 AIC16871.1 - 0.018 14.9 0.4 0.42 10.5 0.0 2.7 3 0 0 3 3 3 0 Avian adenovirus fibre, N-terminal Coatomer_WDAD PF04053.14 AIC16871.1 - 0.025 13.6 0.0 0.4 9.7 0.0 2.1 2 0 0 2 2 2 0 Coatomer WD associated region PQQ PF01011.21 AIC16871.1 - 0.027 14.4 3.5 5.7 7.0 0.1 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat Cytochrom_D1 PF02239.16 AIC16871.1 - 0.14 10.6 1.8 11 4.4 0.1 3.2 2 1 2 4 4 4 0 Cytochrome D1 heme domain FlaG PF03646.15 AIC16871.1 - 2.1 8.6 5.0 41 4.4 0.7 3.6 3 1 1 4 4 4 0 FlaG protein PQQ_3 PF13570.6 AIC16871.1 - 5.6 7.6 9.6 1.9 9.1 0.5 4.4 6 0 0 6 6 6 0 PQQ-like domain tRNA-synt_2 PF00152.20 AIC16872.1 - 2.6e-80 269.9 0.0 3e-80 269.6 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 AIC16872.1 - 3.6e-10 39.7 0.1 7e-10 38.8 0.1 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti-like PF12869.7 AIC16872.1 - 0.014 15.1 0.1 0.024 14.3 0.1 1.3 1 0 0 1 1 1 0 tRNA_anti-like tRNA-synt_2d PF01409.20 AIC16872.1 - 0.099 12.1 0.0 1.6 8.1 0.0 2.6 3 0 0 3 3 3 0 tRNA synthetases class II core domain (F) TetR_N PF00440.23 AIC16873.1 - 5e-15 55.0 0.0 9e-15 54.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 AIC16873.1 - 9.8e-10 38.7 0.2 1.7e-09 37.9 0.1 1.4 2 0 0 2 2 2 1 BetI-type transcriptional repressor, C-terminal TetR_C_31 PF17940.1 AIC16873.1 - 7.2e-08 32.6 0.0 1.3e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_15 PF17918.1 AIC16873.1 - 2.8e-05 24.8 0.0 0.00016 22.4 0.0 2.1 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_33 PF13305.6 AIC16873.1 - 0.037 14.8 0.0 0.35 11.6 0.0 2.2 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MgtC PF02308.16 AIC16875.1 - 6.7e-32 110.4 6.6 9.5e-32 109.9 6.6 1.2 1 0 0 1 1 1 1 MgtC family TrmB PF01978.19 AIC16877.1 - 0.0022 17.9 0.3 0.0045 16.8 0.0 1.6 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB LexA_DNA_bind PF01726.16 AIC16877.1 - 0.004 16.9 0.0 0.01 15.6 0.0 1.6 1 0 0 1 1 1 1 LexA DNA binding domain EII-Sor PF03609.14 AIC16877.1 - 0.011 15.2 0.3 0.017 14.6 0.3 1.2 1 0 0 1 1 1 0 PTS system sorbose-specific iic component DUF4131 PF13567.6 AIC16877.1 - 0.12 12.0 2.6 0.38 10.4 2.5 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) RAMP4 PF06624.12 AIC16877.1 - 0.15 12.2 0.0 0.29 11.2 0.0 1.5 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 PrgI PF12666.7 AIC16877.1 - 1 10.1 4.0 0.51 11.1 0.7 2.1 2 0 0 2 2 2 0 PrgI family protein TctA PF01970.16 AIC16877.1 - 1.6 7.4 6.3 2.7 6.6 6.3 1.3 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctA family NUDIX PF00293.28 AIC16878.1 - 9.7e-18 64.5 0.0 1.5e-17 63.8 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain ADH_N PF08240.12 AIC16879.1 - 5.4e-28 97.1 2.1 5.4e-28 97.1 2.1 1.7 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 AIC16879.1 - 1.8e-21 76.4 1.4 1.8e-21 76.4 1.4 1.6 2 0 0 2 2 2 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 AIC16879.1 - 0.00024 20.5 0.1 0.00043 19.7 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 AIC16879.1 - 0.00044 19.6 1.5 0.00076 18.8 1.5 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ELFV_dehydrog PF00208.21 AIC16879.1 - 0.0041 16.9 0.3 0.0068 16.2 0.3 1.3 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase CoA_binding PF02629.19 AIC16879.1 - 0.0071 17.0 0.8 0.019 15.7 0.8 1.8 1 0 0 1 1 1 1 CoA binding domain Methyltransf_11 PF08241.12 AIC16879.1 - 0.024 15.3 0.2 0.1 13.3 0.2 2.0 1 1 0 1 1 1 0 Methyltransferase domain Gp_dh_N PF00044.24 AIC16879.1 - 0.084 13.2 0.0 0.2 12.0 0.0 1.6 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain ApbA PF02558.16 AIC16879.1 - 0.092 12.4 0.2 0.15 11.7 0.2 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA CitMHS PF03600.16 AIC16880.1 - 1.6e-38 132.6 33.6 2.4e-38 132.0 33.6 1.3 1 0 0 1 1 1 1 Citrate transporter HEAT_2 PF13646.6 AIC16881.1 - 0.0023 18.3 0.4 0.0032 17.8 0.4 1.2 1 0 0 1 1 1 1 HEAT repeats TMEM214 PF10151.9 AIC16881.1 - 0.02 13.4 2.5 0.024 13.1 2.5 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator GUN4_N PF16416.5 AIC16881.1 - 0.086 12.8 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 ARM-like repeat domain, GUN4-N terminal Phage_holin_3_6 PF07332.11 AIC16883.1 - 0.24 11.4 4.8 0.27 11.3 4.8 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3789 PF12664.7 AIC16883.1 - 1.5 8.6 6.8 0.84 9.4 3.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3789) DUF2207 PF09972.9 AIC16883.1 - 6.4 5.4 4.9 6.9 5.3 4.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Albumin_I_a PF16720.5 AIC16886.1 - 0.032 14.1 0.0 0.044 13.7 0.0 1.2 1 0 0 1 1 1 0 Albumin I chain a PsbX PF06596.11 AIC16886.1 - 10 6.2 8.7 1 9.4 1.7 2.1 2 0 0 2 2 2 0 Photosystem II reaction centre X protein (PsbX) NitrOD2 PF18550.1 AIC16890.1 - 4.6e-45 152.0 0.1 5e-45 151.9 0.1 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 Flu_M2 PF00599.17 AIC16892.1 - 0.072 13.2 0.1 0.096 12.8 0.1 1.2 1 0 0 1 1 1 0 Influenza Matrix protein (M2) zf-NPL4 PF05020.15 AIC16892.1 - 0.076 13.2 0.0 0.089 12.9 0.0 1.3 1 0 0 1 1 1 0 NPL4 family, putative zinc binding region DnaG_DnaB_bind PF08278.11 AIC16892.1 - 0.24 12.0 0.0 0.28 11.8 0.0 1.1 1 0 0 1 1 1 0 DNA primase DnaG DnaB-binding PHP_C PF13263.6 AIC16893.1 - 1.1e-10 41.1 0.0 1.9e-10 40.3 0.0 1.4 1 0 0 1 1 1 1 PHP-associated TRAM PF01938.20 AIC16894.1 - 1.5e-13 50.5 2.9 1.7e-13 50.3 2.9 1.1 1 0 0 1 1 1 1 TRAM domain S1 PF00575.23 AIC16894.1 - 0.17 12.3 4.6 3.5 8.1 0.7 2.3 1 1 0 2 2 2 0 S1 RNA binding domain Isochorismatase PF00857.20 AIC16895.1 - 2.1e-42 145.3 0.0 2.5e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 Isochorismatase family DDE_Tnp_IS240 PF13610.6 AIC16896.1 - 2.3e-10 40.8 0.1 3.7e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 DDE domain zf-AN1 PF01428.16 AIC16898.1 - 9.4e-11 41.7 6.8 1.3e-10 41.2 6.8 1.2 1 0 0 1 1 1 1 AN1-like Zinc finger Peptidase_M50 PF02163.22 AIC16898.1 - 0.0016 17.8 9.4 0.0045 16.3 0.6 2.5 1 1 1 2 2 2 2 Peptidase family M50 Transp_Tc5_C PF04236.15 AIC16898.1 - 0.28 11.6 4.0 0.43 11.0 4.0 1.3 1 0 0 1 1 1 0 Tc5 transposase C-terminal domain DUF5510 PF17629.2 AIC16898.1 - 2.3 8.2 4.7 0.84 9.6 0.9 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5510) DUF2024 PF09630.10 AIC16899.1 - 1.2e-09 37.9 0.3 6.2e-09 35.6 0.3 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF2024) YfhD PF14151.6 AIC16899.1 - 0.011 15.9 0.1 0.019 15.1 0.1 1.3 1 0 0 1 1 1 0 YfhD-like protein Guanylate_cyc PF00211.20 AIC16902.1 - 3.9e-11 42.9 0.0 4.7e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Nrf1_DNA-bind PF10491.9 AIC16902.1 - 0.16 11.7 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 Response_reg PF00072.24 AIC16903.1 - 9.4e-22 77.3 0.2 1.1e-21 77.1 0.2 1.0 1 0 0 1 1 1 1 Response regulator receiver domain HATPase_c PF02518.26 AIC16904.1 - 2.9e-26 92.2 0.1 6.9e-26 91.0 0.1 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase PAS_9 PF13426.7 AIC16904.1 - 9.2e-16 58.0 0.1 3.8e-15 56.0 0.0 2.1 2 0 0 2 2 2 1 PAS domain HAMP PF00672.25 AIC16904.1 - 2.3e-15 56.7 0.0 7.7e-15 55.0 0.0 2.0 1 0 0 1 1 1 1 HAMP domain HisKA PF00512.25 AIC16904.1 - 1e-14 54.3 0.4 5.5e-14 51.9 0.0 2.5 2 0 0 2 2 2 1 His Kinase A (phospho-acceptor) domain PAS_3 PF08447.12 AIC16904.1 - 3.6e-13 49.6 0.0 7.4e-13 48.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold dCache_1 PF02743.18 AIC16904.1 - 6.2e-13 49.1 0.6 1.8e-12 47.6 0.2 2.0 2 0 0 2 2 2 1 Cache domain PAS PF00989.25 AIC16904.1 - 5.6e-12 45.7 0.0 1.3e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_4 PF08448.10 AIC16904.1 - 1.9e-09 37.7 0.0 4.3e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 PAS fold PAS_8 PF13188.7 AIC16904.1 - 0.0062 16.5 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 PAS domain DUF5082 PF16888.5 AIC16904.1 - 0.24 11.7 3.6 2.8 8.2 0.7 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF5082) AA_permease_2 PF13520.6 AIC16905.1 - 1.1e-36 126.6 47.2 1.6e-36 126.1 47.2 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 AIC16905.1 - 4.5e-32 111.3 43.2 6.1e-32 110.8 43.2 1.1 1 0 0 1 1 1 1 Amino acid permease Usp PF00582.26 AIC16905.1 - 2.6e-06 28.0 0.3 0.0071 16.9 0.0 3.2 2 1 0 2 2 2 2 Universal stress protein family AA_permease_C PF13906.6 AIC16905.1 - 1.3e-05 25.1 6.5 1.3e-05 25.1 6.5 3.2 2 0 0 2 2 2 1 C-terminus of AA_permease CLP1_P PF16575.5 AIC16906.1 - 3e-23 82.6 0.0 4.4e-23 82.1 0.0 1.2 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop Lyase_aromatic PF00221.19 AIC16906.1 - 0.086 11.5 0.2 0.12 11.0 0.2 1.2 1 0 0 1 1 1 0 Aromatic amino acid lyase FtsK_SpoIIIE PF01580.18 AIC16906.1 - 0.097 12.0 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family QueC PF06508.13 AIC16907.1 - 2.3e-46 158.0 0.0 2.7e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC ThiI PF02568.14 AIC16907.1 - 6.2e-06 25.9 0.0 0.0013 18.4 0.0 2.4 2 1 0 2 2 2 2 Thiamine biosynthesis protein (ThiI) ATP_bind_3 PF01171.20 AIC16907.1 - 0.001 18.9 0.1 0.02 14.7 0.1 2.3 1 1 1 2 2 2 1 PP-loop family Asn_synthase PF00733.21 AIC16907.1 - 0.0042 16.8 0.0 0.0067 16.1 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 AIC16907.1 - 0.022 13.9 0.0 0.07 12.2 0.0 1.7 2 0 0 2 2 2 0 NAD synthase Diphthami_syn_2 PF01902.17 AIC16907.1 - 0.025 14.1 0.0 0.048 13.2 0.0 1.5 1 1 0 1 1 1 0 Diphthamide synthase PTPS PF01242.19 AIC16908.1 - 4.1e-18 65.5 0.0 7.8e-18 64.6 0.0 1.4 1 0 0 1 1 1 1 6-pyruvoyl tetrahydropterin synthase NA37 PF04245.13 AIC16908.1 - 0.06 12.8 0.0 0.13 11.8 0.0 1.5 2 0 0 2 2 2 0 37-kD nucleoid-associated bacterial protein Asn_synthase PF00733.21 AIC16910.1 - 1.4e-31 110.5 0.2 9.1e-21 74.9 0.1 2.0 1 1 1 2 2 2 2 Asparagine synthase NAD_synthase PF02540.17 AIC16910.1 - 1.3e-06 27.7 0.0 2.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 NAD synthase QueC PF06508.13 AIC16910.1 - 2.6e-05 23.8 0.0 3.5e-05 23.4 0.0 1.4 1 1 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 AIC16910.1 - 0.0028 16.5 0.1 0.008 15.0 0.1 1.7 1 1 0 1 1 1 1 tRNA methyl transferase ATP_bind_3 PF01171.20 AIC16910.1 - 0.0058 16.4 0.1 0.01 15.6 0.1 1.5 1 0 0 1 1 1 1 PP-loop family HTH_45 PF14947.6 AIC16911.1 - 0.0074 16.2 0.9 0.0094 15.9 0.2 1.6 2 0 0 2 2 2 1 Winged helix-turn-helix Sulfolobus_pRN PF05584.11 AIC16911.1 - 0.039 14.0 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 Sulfolobus plasmid regulatory protein Rio2_N PF09202.11 AIC16911.1 - 0.058 13.6 0.1 0.19 11.9 0.0 1.8 2 0 0 2 2 2 0 Rio2, N-terminal DUF4209 PF13910.6 AIC16911.1 - 0.13 12.5 0.0 12 6.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4209) UbiA PF01040.18 AIC16912.1 - 3.6e-32 111.7 17.2 4.4e-32 111.3 16.7 1.3 1 1 0 1 1 1 1 UbiA prenyltransferase family Lig_chan PF00060.26 AIC16912.1 - 0.28 11.0 3.2 8.3 6.2 0.0 2.5 2 0 0 2 2 2 0 Ligand-gated ion channel PRA1 PF03208.19 AIC16912.1 - 2.8 7.6 20.7 1.2 8.7 12.3 3.0 3 1 1 4 4 4 0 PRA1 family protein HTH_45 PF14947.6 AIC16913.1 - 0.00093 19.1 0.2 0.0021 18.0 0.2 1.6 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_20 PF12840.7 AIC16913.1 - 0.0044 17.1 0.0 0.017 15.2 0.0 2.0 2 0 0 2 2 2 1 Helix-turn-helix domain TrmB PF01978.19 AIC16913.1 - 0.085 12.8 0.2 0.74 9.7 0.0 2.3 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIC16913.1 - 0.11 12.0 0.2 3.2 7.4 0.0 2.5 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding Hydrolase_4 PF12146.8 AIC16914.1 - 3e-29 102.0 0.1 6.3e-29 100.9 0.0 1.5 2 0 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 AIC16914.1 - 2e-18 67.0 0.0 2.6e-14 53.5 0.1 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 AIC16914.1 - 2.1e-17 64.5 0.0 2.9e-17 64.0 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family LIDHydrolase PF10230.9 AIC16914.1 - 2e-05 24.3 0.2 8e-05 22.3 0.2 1.9 1 1 0 1 1 1 1 Lipid-droplet associated hydrolase DUF1057 PF06342.12 AIC16914.1 - 0.00041 19.5 0.0 0.00066 18.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1057) DLH PF01738.18 AIC16914.1 - 0.00075 19.1 0.0 0.056 13.0 0.0 2.7 2 1 0 2 2 2 1 Dienelactone hydrolase family Peptidase_S9 PF00326.21 AIC16914.1 - 0.002 17.6 3.5 0.0025 17.3 0.0 2.5 3 0 0 3 3 3 1 Prolyl oligopeptidase family DUF1749 PF08538.10 AIC16914.1 - 0.0021 17.2 0.0 0.0049 16.0 0.0 1.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1749) Asp2 PF16929.5 AIC16914.1 - 0.0074 15.3 0.0 0.015 14.3 0.0 1.5 1 1 0 1 1 1 1 Accessory Sec system GspB-transporter FSH1 PF03959.13 AIC16914.1 - 0.013 15.2 0.0 3.2 7.4 0.0 2.9 2 1 0 2 2 2 0 Serine hydrolase (FSH1) Abhydrolase_5 PF12695.7 AIC16914.1 - 0.045 13.5 0.0 0.56 9.9 0.0 2.5 2 1 0 2 2 2 0 Alpha/beta hydrolase family PGAP1 PF07819.13 AIC16914.1 - 0.064 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 PGAP1-like protein Peptidase_S15 PF02129.18 AIC16914.1 - 0.069 12.7 0.0 9 5.8 0.0 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) DUF900 PF05990.12 AIC16914.1 - 0.1 12.1 0.0 0.46 9.9 0.0 1.9 2 0 0 2 2 2 0 Alpha/beta hydrolase of unknown function (DUF900) LCAT PF02450.15 AIC16914.1 - 0.11 11.7 0.2 0.23 10.6 0.2 1.7 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase Ser_hydrolase PF06821.13 AIC16914.1 - 0.13 12.1 0.0 0.21 11.4 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase Methyltransf_31 PF13847.6 AIC16915.1 - 5.9e-18 65.1 0.0 8.2e-18 64.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC16915.1 - 3.5e-14 53.2 0.0 6.1e-14 52.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 AIC16915.1 - 5.2e-14 52.7 0.0 1.1e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC16915.1 - 1.8e-11 44.2 0.0 2.5e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC16915.1 - 1.4e-08 35.4 0.0 2.4e-08 34.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 AIC16915.1 - 9.2e-06 25.9 0.0 2.6e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 AIC16915.1 - 2.9e-05 23.9 0.0 5e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 AIC16915.1 - 3e-05 23.5 0.0 4.4e-05 22.9 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_24 PF13578.6 AIC16915.1 - 0.0015 19.5 0.0 0.0025 18.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 AIC16915.1 - 0.0023 16.9 0.0 0.0037 16.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) GidB PF02527.15 AIC16915.1 - 0.0092 15.3 0.0 0.015 14.6 0.0 1.2 1 0 0 1 1 1 1 rRNA small subunit methyltransferase G GCD14 PF08704.10 AIC16915.1 - 0.034 13.8 0.0 0.064 12.9 0.0 1.4 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_32 PF13679.6 AIC16915.1 - 0.073 13.1 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 AIC16915.1 - 0.079 12.0 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase CMAS PF02353.20 AIC16915.1 - 0.08 12.2 0.1 0.15 11.4 0.1 1.4 1 1 0 1 1 1 0 Mycolic acid cyclopropane synthetase PAS_3 PF08447.12 AIC16915.1 - 0.099 12.9 0.5 2.9 8.2 0.0 2.7 2 1 1 3 3 3 0 PAS fold PHO4 PF01384.20 AIC16917.1 - 2.1e-86 290.1 37.2 7.4e-86 288.3 37.2 1.7 1 1 0 1 1 1 1 Phosphate transporter family PhoU_div PF01865.16 AIC16918.1 - 1.1e-24 86.9 4.9 1.3e-24 86.7 4.9 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF47 PMC2NT PF08066.12 AIC16918.1 - 0.024 15.3 3.6 0.032 14.9 1.0 2.4 2 2 0 2 2 2 0 PMC2NT (NUC016) domain zf-C2H2 PF00096.26 AIC16919.1 - 0.0022 18.3 1.8 0.0075 16.7 0.6 2.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC16919.1 - 0.0026 18.4 2.3 0.022 15.6 0.6 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 AIC16919.1 - 0.0034 17.6 0.3 0.053 13.8 0.0 2.2 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding BNR PF02012.20 AIC16921.1 - 3.4 8.0 24.4 6.3 7.2 1.2 5.7 4 0 0 4 4 4 0 BNR/Asp-box repeat NST1 PF13945.6 AIC16921.1 - 8.5 6.4 8.9 14 5.7 8.9 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator TrmB PF01978.19 AIC16922.1 - 9.7e-05 22.2 0.1 0.00012 21.9 0.1 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 AIC16922.1 - 0.0012 18.7 0.1 0.0018 18.1 0.1 1.2 1 0 0 1 1 1 1 MarR family HTH_45 PF14947.6 AIC16922.1 - 0.0042 17.0 0.0 0.0049 16.8 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_24 PF13412.6 AIC16922.1 - 0.0049 16.4 0.0 0.008 15.7 0.0 1.3 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 AIC16922.1 - 0.0067 16.3 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 MarR family Penicillinase_R PF03965.16 AIC16922.1 - 0.025 14.9 0.2 0.034 14.5 0.2 1.2 1 0 0 1 1 1 0 Penicillinase repressor HTH_34 PF13601.6 AIC16922.1 - 0.026 14.7 0.1 0.035 14.3 0.1 1.1 1 0 0 1 1 1 0 Winged helix DNA-binding domain NOC3p PF07540.11 AIC16922.1 - 0.029 14.8 0.0 0.049 14.1 0.0 1.3 1 0 0 1 1 1 0 Nucleolar complex-associated protein HicA_toxin PF07927.12 AIC16922.1 - 0.029 14.4 0.2 0.16 12.1 0.1 1.9 2 0 0 2 2 2 0 HicA toxin of bacterial toxin-antitoxin, DUF4364 PF14277.6 AIC16922.1 - 0.036 13.8 0.0 0.042 13.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) Rrf2 PF02082.20 AIC16922.1 - 0.066 13.6 0.0 0.08 13.3 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator TFIIE_alpha PF02002.17 AIC16922.1 - 0.074 12.9 0.1 0.091 12.6 0.1 1.1 1 0 0 1 1 1 0 TFIIE alpha subunit FtsK_gamma PF09397.10 AIC16922.1 - 0.12 12.1 0.1 0.21 11.4 0.1 1.4 1 1 0 1 1 1 0 Ftsk gamma domain PadR PF03551.14 AIC16922.1 - 0.13 12.3 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family DUF308 PF03729.13 AIC16924.1 - 0.0078 16.5 0.1 0.024 15.0 0.1 1.8 2 0 0 2 2 2 1 Short repeat of unknown function (DUF308) DUF4366 PF14283.6 AIC16924.1 - 0.081 13.0 0.0 0.097 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) BON PF04972.17 AIC16925.1 - 0.08 13.3 0.1 0.094 13.0 0.1 1.2 1 0 0 1 1 1 0 BON domain Defensin_beta_2 PF13841.6 AIC16926.1 - 0.046 14.2 1.7 0.39 11.2 0.1 2.1 2 0 0 2 2 2 0 Beta defensin T6SS_HCP PF05638.12 AIC16927.1 - 3.1e-41 140.8 0.1 4e-41 140.4 0.1 1.1 1 0 0 1 1 1 1 Type VI secretion system effector, Hcp Pilin_N PF07790.11 AIC16927.1 - 0.032 15.1 0.7 0.078 13.9 0.2 1.9 2 0 0 2 2 2 0 Archaeal Type IV pilin, N-terminal SSURE PF11966.8 AIC16927.1 - 0.035 13.8 0.0 0.083 12.6 0.0 1.7 1 0 0 1 1 1 0 Fibronectin-binding repeat FAD_binding_4 PF01565.23 AIC16929.1 - 0.031 14.0 0.3 0.059 13.1 0.2 1.5 1 1 1 2 2 2 0 FAD binding domain FliD_N PF02465.18 AIC16929.1 - 0.3 11.8 6.4 7.9 7.3 1.4 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus rve_3 PF13683.6 AIC16931.1 - 0.037 13.8 0.1 0.22 11.3 0.0 2.1 2 1 0 2 2 2 0 Integrase core domain DUF72 PF01904.18 AIC16932.1 - 5.5e-61 206.4 0.1 6.5e-61 206.2 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF72 Mob_synth_C PF06463.13 AIC16934.1 - 0.044 13.7 3.0 0.074 13.0 3.0 1.4 1 0 0 1 1 1 0 Molybdenum Cofactor Synthesis C DUF3530 PF12048.8 AIC16935.1 - 0.026 13.9 1.8 0.04 13.3 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) CCDC32 PF14989.6 AIC16935.1 - 0.066 13.2 2.2 0.11 12.5 2.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing 32 AAA_22 PF13401.6 AIC16936.1 - 0.0017 18.6 0.0 0.0066 16.7 0.0 1.8 2 0 0 2 2 2 1 AAA domain DEAD PF00270.29 AIC16936.1 - 0.0087 15.8 0.0 0.018 14.8 0.0 1.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase TPM_phosphatase PF04536.14 AIC16936.1 - 0.0098 16.1 0.1 0.14 12.4 0.0 2.5 3 0 0 3 3 3 1 TPM domain Astro_capsid_p2 PF16580.5 AIC16936.1 - 0.2 11.1 0.1 3 7.2 0.0 2.1 2 0 0 2 2 2 0 C-terminal tail of astrovirus capsid projection or spike MukF_M PF17192.4 AIC16939.1 - 0.1 12.3 0.3 12 5.6 0.0 2.4 2 0 0 2 2 2 0 MukF middle domain RelA_SpoT PF04607.17 AIC16940.1 - 6.8e-22 78.0 0.6 1.8e-21 76.6 0.6 1.7 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins NolB PF17398.2 AIC16940.1 - 0.0013 19.1 0.2 0.002 18.5 0.2 1.2 1 0 0 1 1 1 1 Nodulation protein NolB GrpE PF01025.19 AIC16940.1 - 0.04 13.6 3.4 2.7 7.7 0.1 2.1 2 0 0 2 2 2 0 GrpE DUF2990 PF11693.8 AIC16940.1 - 0.089 13.0 0.1 0.42 10.8 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) VWA_3_C PF18571.1 AIC16943.1 - 0.098 12.5 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A C-terminal domain TBCA PF02970.16 AIC16945.1 - 0.021 15.2 0.1 0.027 14.8 0.1 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A DUF202 PF02656.15 AIC16946.1 - 1 9.8 7.0 2 8.9 7.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF202) TF_Zn_Ribbon PF08271.12 AIC16947.1 - 0.14 11.7 6.3 0.43 10.1 3.7 2.4 2 0 0 2 2 2 0 TFIIB zinc-binding DUF5353 PF17304.2 AIC16949.1 - 0.17 11.6 0.0 0.18 11.6 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5353) Sec34 PF04136.15 AIC16955.1 - 0.0083 16.0 7.4 0.012 15.5 0.2 2.7 2 0 0 2 2 2 1 Sec34-like family V-SNARE_C PF12352.8 AIC16955.1 - 0.018 15.3 3.8 2.6 8.4 0.1 2.9 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus RE_HaeIII PF09556.10 AIC16955.1 - 0.12 11.5 0.6 0.38 9.8 0.6 1.9 1 0 0 1 1 1 0 HaeIII restriction endonuclease Prominin PF05478.11 AIC16955.1 - 0.19 9.6 1.3 2.5 6.0 0.5 2.2 2 0 0 2 2 2 0 Prominin MerR-DNA-bind PF09278.11 AIC16955.1 - 0.48 11.0 3.7 1.6 9.3 0.7 3.3 3 0 0 3 3 3 0 MerR, DNA binding Exonuc_VII_L PF02601.15 AIC16955.1 - 0.67 9.5 21.7 0.31 10.6 5.5 3.0 2 1 1 3 3 3 0 Exonuclease VII, large subunit NleF_casp_inhib PF16809.5 AIC16955.1 - 0.73 9.7 3.9 3.4 7.5 0.4 2.7 2 0 0 2 2 2 0 NleF caspase inhibitor Baculo_PEP_C PF04513.12 AIC16955.1 - 5.6 7.0 11.4 1.3 9.1 0.3 3.8 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DZR PF12773.7 AIC16956.1 - 2.7e-10 40.1 9.6 9.2e-10 38.4 9.9 1.7 1 1 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 AIC16956.1 - 6.6e-10 38.4 16.8 4.5e-06 26.2 2.5 2.3 2 0 0 2 2 2 2 zinc-ribbon domain zf-ribbon_3 PF13248.6 AIC16956.1 - 9.4e-05 21.7 18.1 0.024 14.0 4.7 2.3 2 0 0 2 2 2 2 zinc-ribbon domain zf-RanBP PF00641.18 AIC16956.1 - 0.012 15.0 11.9 0.13 11.6 1.6 2.2 2 0 0 2 2 2 0 Zn-finger in Ran binding protein and others zinc_ribbon_15 PF17032.5 AIC16956.1 - 0.012 16.4 6.5 0.22 12.3 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon family zf-C6H2 PF15801.5 AIC16956.1 - 0.023 15.0 9.6 1.7 9.0 3.2 2.4 1 1 1 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding DUF2321 PF10083.9 AIC16956.1 - 0.27 10.9 7.2 0.53 9.9 4.0 2.5 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2321) Nudix_N_2 PF14803.6 AIC16956.1 - 0.31 11.0 15.0 0.99 9.4 0.3 4.1 4 0 0 4 4 4 0 Nudix N-terminal Cript PF10235.9 AIC16956.1 - 0.38 11.4 3.8 0.46 11.1 0.2 2.2 1 1 1 2 2 2 0 Microtubule-associated protein CRIPT zf-B_box PF00643.24 AIC16956.1 - 0.39 10.9 4.1 2.8 8.2 2.0 2.3 1 1 1 2 2 2 0 B-box zinc finger HypA PF01155.19 AIC16956.1 - 0.8 9.8 6.2 0.57 10.2 3.5 2.2 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA TackOD1 PF18551.1 AIC16956.1 - 1.1 8.9 8.7 2.7 7.6 2.6 2.2 2 0 0 2 2 2 0 Thaumarchaeal output domain 1 DHHC PF01529.20 AIC16956.1 - 1.9 8.6 3.5 4.9 7.3 0.3 2.1 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF3614 PF12267.8 AIC16958.1 - 0.18 12.3 2.4 11 6.5 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3614) W_rich_C PF07483.11 AIC16960.1 - 0.071 13.3 0.1 0.18 12.0 0.1 1.7 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain DUF1522 PF07482.11 AIC16960.1 - 0.21 11.9 4.1 0.96 9.8 0.3 3.5 2 2 0 2 2 2 0 Domain of Unknown Function (DUF1522) DUF3585 PF12130.8 AIC16962.1 - 0.0059 16.7 1.2 0.0075 16.4 1.2 1.2 1 0 0 1 1 1 1 Bivalent Mical/EHBP Rab binding domain DUF2710 PF10921.8 AIC16962.1 - 0.053 13.9 0.4 0.086 13.3 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2710) DUF2498 PF10692.9 AIC16962.1 - 0.089 12.7 0.1 0.14 12.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2498) Spidroin_MaSp PF11260.8 AIC16963.1 - 0.054 13.8 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 Major ampullate spidroin 1 and 2 PGDH_C PF16896.5 AIC16963.1 - 0.091 12.7 0.0 0.1 12.5 0.0 1.2 1 0 0 1 1 1 0 Phosphogluconate dehydrogenase (decarboxylating) C-term TP_methylase PF00590.20 AIC16966.1 - 2.1e-35 122.6 0.1 2.5e-35 122.4 0.1 1.1 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Cu-oxidase_3 PF07732.15 AIC16967.1 - 1.9e-26 92.4 3.4 4e-21 75.2 0.1 2.4 2 0 0 2 2 2 2 Multicopper oxidase Cu-oxidase_2 PF07731.14 AIC16967.1 - 2.8e-26 91.9 8.3 2.3e-14 53.3 0.8 3.2 3 0 0 3 3 3 3 Multicopper oxidase Cupredoxin_1 PF13473.6 AIC16967.1 - 0.0081 16.3 0.0 2.7 8.2 0.0 3.1 2 1 1 3 3 3 1 Cupredoxin-like domain GAPES2 PF17156.4 AIC16967.1 - 0.11 12.2 1.0 0.2 11.4 1.0 1.3 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain Lipase_C PF18067.1 AIC16967.1 - 1.1 9.8 3.7 2.9 8.5 0.1 3.1 3 1 0 3 3 3 0 Lipase C-terminal domain PepSY PF03413.19 AIC16969.1 - 0.0044 17.5 0.1 0.0087 16.6 0.1 1.5 1 0 0 1 1 1 1 Peptidase propeptide and YPEB domain PepSY PF03413.19 AIC16970.1 - 0.095 13.3 0.2 0.18 12.4 0.2 1.4 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain DUF2106 PF09879.9 AIC16970.1 - 0.15 11.6 0.2 0.19 11.3 0.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2106) PepSY PF03413.19 AIC16972.1 - 4.8e-09 36.6 0.9 0.00017 22.1 0.0 2.3 2 0 0 2 2 2 2 Peptidase propeptide and YPEB domain DUF1147 PF06615.11 AIC16972.1 - 0.069 13.2 0.0 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1147) TRAP_beta PF05753.14 AIC16972.1 - 0.077 12.4 0.7 10 5.5 0.0 2.3 2 0 0 2 2 2 0 Translocon-associated protein beta (TRAPB) dTDP_sugar_isom PF00908.17 AIC16972.1 - 0.19 11.4 0.0 22 4.7 0.0 2.3 2 0 0 2 2 2 0 dTDP-4-dehydrorhamnose 3,5-epimerase GRIM-19 PF06212.12 AIC16973.1 - 0.0052 16.7 0.0 0.0076 16.2 0.0 1.2 1 0 0 1 1 1 1 GRIM-19 protein HTH_45 PF14947.6 AIC16974.1 - 3e-07 30.3 0.8 3.9e-07 30.0 0.8 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIC16974.1 - 6.5e-06 26.0 0.0 9.9e-06 25.4 0.0 1.2 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIC16974.1 - 0.0013 18.6 0.0 0.0017 18.2 0.0 1.3 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB MarR_2 PF12802.7 AIC16974.1 - 0.098 12.6 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 MarR family RP-C PF03428.13 AIC16974.1 - 0.17 11.5 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Replication protein C N-terminal domain 7TM-7TMR_HD PF07698.11 AIC16975.1 - 0.024 14.4 4.8 0.032 14.0 4.8 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase UCR_Fe-S_N PF10399.9 AIC16975.1 - 3.5 7.1 6.9 0.42 10.0 0.5 2.4 2 0 0 2 2 2 0 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal ABC_tran PF00005.27 AIC16976.1 - 1.7e-35 122.5 0.0 2.7e-35 121.9 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 AIC16976.1 - 7.6e-08 32.0 0.2 0.0024 17.4 0.0 2.4 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AIC16976.1 - 9.4e-07 28.9 1.1 0.016 15.0 0.8 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AIC16976.1 - 5.7e-05 22.8 0.1 0.00012 21.8 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AIC16976.1 - 0.00012 22.1 0.2 0.00031 20.7 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 AIC16976.1 - 0.0004 20.7 0.3 0.0026 18.0 0.3 2.1 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 AIC16976.1 - 0.00041 20.1 0.0 0.025 14.3 0.0 2.2 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 AIC16976.1 - 0.00063 20.2 0.0 0.00077 19.9 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_15 PF13175.6 AIC16976.1 - 0.0014 18.4 0.6 0.8 9.3 0.1 2.1 1 1 0 2 2 2 2 AAA ATPase domain AAA_23 PF13476.6 AIC16976.1 - 0.0032 18.0 0.1 0.0056 17.2 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 AIC16976.1 - 0.0073 16.0 0.1 0.019 14.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AIC16976.1 - 0.0087 16.1 0.5 0.021 14.9 0.4 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_25 PF13481.6 AIC16976.1 - 0.016 14.7 0.3 0.12 11.9 0.2 2.1 2 0 0 2 2 2 0 AAA domain cobW PF02492.19 AIC16976.1 - 0.018 14.6 0.1 0.037 13.6 0.1 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain TniB PF05621.11 AIC16976.1 - 0.025 14.0 0.4 1.2 8.6 0.1 2.1 2 0 0 2 2 2 0 Bacterial TniB protein AAA_33 PF13671.6 AIC16976.1 - 0.029 14.5 0.4 0.12 12.6 0.4 2.1 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 AIC16976.1 - 0.038 13.2 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_28 PF13521.6 AIC16976.1 - 0.039 14.2 0.1 0.071 13.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 AIC16976.1 - 0.049 13.5 0.0 0.087 12.7 0.0 1.5 1 1 0 1 1 1 0 Rad17 P-loop domain SRP54 PF00448.22 AIC16976.1 - 0.073 12.7 0.0 0.18 11.4 0.0 1.6 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain AAA_18 PF13238.6 AIC16976.1 - 0.11 13.1 0.3 0.2 12.2 0.2 1.6 1 1 0 1 1 1 0 AAA domain DIM PF08194.12 AIC16976.1 - 0.11 12.7 0.1 0.31 11.3 0.1 1.7 1 0 0 1 1 1 0 DIM protein Dynamin_N PF00350.23 AIC16976.1 - 0.12 12.4 0.1 0.22 11.6 0.1 1.4 1 0 0 1 1 1 0 Dynamin family AAA_24 PF13479.6 AIC16976.1 - 0.18 11.5 0.2 0.37 10.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 AIC16976.1 - 0.18 11.7 0.1 0.47 10.3 0.1 1.7 2 0 0 2 2 2 0 NACHT domain NPCBM_assoc PF10633.9 AIC16977.1 - 1.3e-05 25.3 8.2 1 9.7 0.1 5.1 4 1 0 4 4 4 3 NPCBM-associated, NEW3 domain of alpha-galactosidase CARDB PF07705.11 AIC16977.1 - 0.0085 16.3 13.3 0.19 12.0 0.5 4.2 3 1 0 3 3 3 1 CARDB Orf78 PF06024.12 AIC16977.1 - 0.076 13.3 0.1 0.23 11.8 0.1 1.8 1 0 0 1 1 1 0 Orf78 (ac78) DUF2749 PF10907.8 AIC16977.1 - 0.11 12.7 0.4 0.78 9.9 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) TRAP_alpha PF03896.16 AIC16977.1 - 0.17 11.1 0.1 8.2 5.5 0.0 3.2 3 1 0 3 3 3 0 Translocon-associated protein (TRAP), alpha subunit DUF5385 PF17359.2 AIC16977.1 - 0.19 11.3 0.1 0.27 10.8 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) LapA_dom PF06305.11 AIC16977.1 - 0.21 11.4 3.9 0.2 11.5 0.3 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain TRAP_beta PF05753.14 AIC16977.1 - 0.55 9.6 3.4 7.5 5.9 0.0 3.6 4 0 0 4 4 4 0 Translocon-associated protein beta (TRAPB) FtsX PF02687.21 AIC16978.1 - 5.4e-14 52.4 2.4 5.4e-14 52.4 2.4 3.2 3 0 0 3 3 3 2 FtsX-like permease family MacB_PCD PF12704.7 AIC16978.1 - 3.5e-12 47.1 7.0 3.5e-12 47.1 7.0 2.8 2 1 0 3 3 3 1 MacB-like periplasmic core domain AA_kinase PF00696.28 AIC16980.1 - 5.4e-53 180.1 0.7 5.4e-53 180.1 0.7 2.0 2 0 0 2 2 2 1 Amino acid kinase family ACT_7 PF13840.6 AIC16980.1 - 9.8e-21 73.3 1.9 3.1e-09 36.5 0.3 2.5 2 0 0 2 2 2 2 ACT domain ACT PF01842.25 AIC16980.1 - 1.2e-18 66.5 0.4 2.4e-08 33.6 0.1 2.9 2 0 0 2 2 2 2 ACT domain ACT_6 PF13740.6 AIC16980.1 - 0.037 14.0 2.4 0.35 10.9 0.1 3.4 2 1 0 3 3 3 0 ACT domain PCNA_N PF00705.18 AIC16981.1 - 2.5e-17 62.8 0.0 5.1e-16 58.6 0.0 2.0 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 AIC16981.1 - 4.2e-16 59.3 0.0 1.5e-14 54.3 0.0 2.6 2 1 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 AIC16981.1 - 1.9e-06 27.2 0.1 0.0098 15.0 0.0 2.1 1 1 0 2 2 2 2 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 AIC16981.1 - 0.00065 19.2 0.0 0.00086 18.8 0.0 1.1 1 0 0 1 1 1 1 Rad9 Cation_efflux PF01545.21 AIC16983.1 - 5.7e-33 114.3 14.4 6.8e-33 114.1 14.4 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 AIC16983.1 - 0.00011 22.3 0.0 0.00023 21.2 0.0 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF4396 PF14342.6 AIC16983.1 - 0.12 12.7 3.4 0.08 13.3 0.8 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4396) DUF4536 PF15055.6 AIC16983.1 - 0.23 11.7 2.8 0.31 11.3 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4536) DUF3180 PF11377.8 AIC16983.1 - 0.5 10.5 5.9 0.39 10.9 1.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3180) GARS_A PF01071.19 AIC16984.1 - 1.3e-16 61.0 0.0 3.7e-16 59.5 0.0 1.8 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain GARS_C PF02843.16 AIC16984.1 - 8.4e-10 38.8 0.1 2.6e-09 37.2 0.1 2.1 1 1 0 1 1 1 1 Phosphoribosylglycinamide synthetase, C domain AsnC_trans_reg PF01037.21 AIC16985.1 - 5.1e-15 55.2 0.3 6.2e-15 54.9 0.3 1.1 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain GYD PF08734.11 AIC16985.1 - 0.002 18.0 0.0 0.0024 17.8 0.0 1.2 1 0 0 1 1 1 1 GYD domain NapD PF03927.13 AIC16985.1 - 0.012 15.6 0.3 0.016 15.2 0.3 1.2 1 0 0 1 1 1 0 NapD protein MatB PF16449.5 AIC16985.1 - 0.076 12.8 0.0 0.092 12.5 0.0 1.2 1 0 0 1 1 1 0 Fimbrillin MatB Vut_1 PF02592.15 AIC16986.1 - 0.036 14.4 1.1 0.055 13.8 0.3 1.8 2 0 0 2 2 2 0 Putative vitamin uptake transporter AsnC_trans_reg PF01037.21 AIC16987.1 - 4.3e-09 36.2 0.1 5e-09 36.0 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIC16987.1 - 0.00051 20.0 0.1 0.00065 19.7 0.1 1.1 1 0 0 1 1 1 1 NapD protein GYD PF08734.11 AIC16987.1 - 0.022 14.7 0.0 0.027 14.4 0.0 1.1 1 0 0 1 1 1 0 GYD domain KdpC PF02669.15 AIC16989.1 - 3.2e-36 124.9 0.2 5.6e-21 75.2 0.0 2.0 1 1 1 2 2 2 2 K+-transporting ATPase, c chain E1-E2_ATPase PF00122.20 AIC16990.1 - 1.8e-35 122.1 0.7 1.8e-35 122.1 0.7 2.3 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 AIC16990.1 - 3e-24 86.5 0.9 6.5e-24 85.4 0.9 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 AIC16990.1 - 0.00049 19.9 3.8 0.00075 19.3 0.8 2.2 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 AIC16990.1 - 0.02 15.3 0.0 0.078 13.4 0.0 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase PDEase_I PF00233.19 AIC16990.1 - 0.16 11.6 0.1 0.58 9.8 0.0 1.9 2 0 0 2 2 2 0 3'5'-cyclic nucleotide phosphodiesterase KdpA PF03814.15 AIC16991.1 - 5.2e-176 586.1 39.5 7.7e-176 585.5 39.5 1.1 1 0 0 1 1 1 1 Potassium-transporting ATPase A subunit TFIIS_C PF01096.18 AIC16992.1 - 1.8e-18 66.1 7.2 1.8e-18 66.1 7.2 3.1 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) zf-ribbon_3 PF13248.6 AIC16992.1 - 5e-06 25.7 12.4 5.8e-05 22.4 2.8 3.4 3 1 0 3 3 3 2 zinc-ribbon domain DZR PF12773.7 AIC16992.1 - 4.9e-05 23.3 11.8 5.3e-05 23.2 1.8 2.8 1 1 2 3 3 3 1 Double zinc ribbon Prok-RING_1 PF14446.6 AIC16992.1 - 0.00024 21.0 1.6 0.00024 21.0 1.6 2.7 3 0 0 3 3 3 1 Prokaryotic RING finger family 1 RNA_POL_M_15KD PF02150.16 AIC16992.1 - 0.00043 20.1 9.2 0.0051 16.7 1.2 2.8 2 1 0 2 2 2 1 RNA polymerases M/15 Kd subunit zinc_ribbon_4 PF13717.6 AIC16992.1 - 0.00054 19.8 15.7 0.13 12.2 1.3 4.2 3 1 0 3 3 3 1 zinc-ribbon domain Zn_Tnp_IS1595 PF12760.7 AIC16992.1 - 0.0017 18.2 12.6 0.037 14.0 0.5 3.3 2 1 1 3 3 3 2 Transposase zinc-ribbon domain zinc-ribbons_6 PF07191.12 AIC16992.1 - 0.0029 17.5 8.7 0.033 14.2 0.4 2.5 2 1 0 2 2 2 1 zinc-ribbons OrfB_Zn_ribbon PF07282.11 AIC16992.1 - 0.0041 17.0 0.8 0.0041 17.0 0.8 2.9 1 1 2 3 3 3 1 Putative transposase DNA-binding domain UPF0547 PF10571.9 AIC16992.1 - 0.0043 17.1 9.7 0.43 10.7 0.1 3.8 4 0 0 4 4 4 1 Uncharacterised protein family UPF0547 TF_Zn_Ribbon PF08271.12 AIC16992.1 - 0.0046 16.5 10.9 0.15 11.6 3.0 2.6 2 1 0 2 2 2 2 TFIIB zinc-binding zf-DNA_Pol PF08996.10 AIC16992.1 - 0.0058 16.4 0.4 0.0058 16.4 0.4 1.8 2 1 0 2 2 2 1 DNA Polymerase alpha zinc finger Zn-ribbon_8 PF09723.10 AIC16992.1 - 0.0077 16.3 13.1 2.2 8.5 4.2 4.0 3 1 0 3 3 3 1 Zinc ribbon domain Baculo_LEF5_C PF11792.8 AIC16992.1 - 0.0099 15.5 3.4 0.021 14.5 0.0 2.6 2 1 0 2 2 2 1 Baculoviridae late expression factor 5 C-terminal domain zinc_ribbon_2 PF13240.6 AIC16992.1 - 0.012 15.4 3.5 0.012 15.4 3.5 3.2 3 1 0 3 3 3 0 zinc-ribbon domain zf_UBZ PF18439.1 AIC16992.1 - 0.015 14.9 10.7 7.8 6.2 0.1 4.2 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger RPA_interact_C PF14768.6 AIC16992.1 - 0.028 15.0 6.6 2.3 8.9 6.6 2.8 1 1 0 1 1 1 0 Replication protein A interacting C-terminal DNA_RNApol_7kD PF03604.13 AIC16992.1 - 0.057 13.1 9.2 0.081 12.6 1.2 3.2 3 0 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit HypA PF01155.19 AIC16992.1 - 0.12 12.4 11.4 0.24 11.4 1.9 3.1 1 1 2 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-TFIIB PF13453.6 AIC16992.1 - 0.14 11.5 14.3 1.5 8.2 2.1 3.5 2 2 1 3 3 3 0 Transcription factor zinc-finger DUF2752 PF10825.8 AIC16992.1 - 0.15 12.2 0.4 2.2 8.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2752) zf-ZPR1 PF03367.13 AIC16992.1 - 0.16 11.8 7.0 0.87 9.4 0.5 2.5 3 0 0 3 3 3 0 ZPR1 zinc-finger domain zinc_ribbon_9 PF14369.6 AIC16992.1 - 0.17 12.2 9.9 1 9.7 3.5 3.3 3 1 0 3 3 3 0 zinc-ribbon A2L_zn_ribbon PF08792.10 AIC16992.1 - 0.17 11.6 11.5 2.2 8.1 0.0 4.0 4 0 0 4 4 4 0 A2L zinc ribbon domain DnaJ_CXXCXGXG PF00684.19 AIC16992.1 - 0.45 10.9 7.5 1.5e+02 2.8 7.5 2.5 1 1 0 1 1 1 0 DnaJ central domain Lar_restr_allev PF14354.6 AIC16992.1 - 0.46 10.9 8.9 0.4 11.1 3.8 2.7 2 1 0 2 2 2 0 Restriction alleviation protein Lar zf-RING_4 PF14570.6 AIC16992.1 - 0.48 10.2 6.6 4 7.3 1.3 3.2 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Elf1 PF05129.13 AIC16992.1 - 0.64 10.1 8.5 0.17 12.0 2.0 2.8 2 2 0 2 2 2 0 Transcription elongation factor Elf1 like zinc_ribbon_5 PF13719.6 AIC16992.1 - 0.74 9.6 15.6 14 5.6 0.8 4.1 3 1 0 3 3 3 0 zinc-ribbon domain zinc_ribbon_10 PF10058.9 AIC16992.1 - 0.81 9.5 8.0 2.6 7.8 1.8 3.3 3 1 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein PHD PF00628.29 AIC16992.1 - 0.81 9.6 10.0 5.4 7.0 0.7 2.9 2 1 0 2 2 2 0 PHD-finger zf-Mss51 PF13824.6 AIC16992.1 - 1.2 9.3 10.6 0.66 10.1 1.6 2.5 2 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 FYDLN_acid PF09538.10 AIC16992.1 - 1.3 9.7 8.0 1.3 9.7 2.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) C1_4 PF07975.12 AIC16992.1 - 1.4 9.2 11.3 1.7 9.0 0.4 3.2 2 2 1 3 3 3 0 TFIIH C1-like domain zf-IS66 PF13005.7 AIC16992.1 - 1.7 9.1 12.3 1.4 9.3 0.2 3.8 3 1 1 4 4 4 0 zinc-finger binding domain of transposase IS66 Ogr_Delta PF04606.12 AIC16992.1 - 1.8 8.6 10.9 12 6.0 0.0 3.4 3 1 0 3 3 3 0 Ogr/Delta-like zinc finger Zn_Tnp_IS1 PF03811.13 AIC16992.1 - 1.9 8.3 14.1 6.6 6.5 5.0 4.0 3 1 0 3 3 3 0 InsA N-terminal domain DUF3797 PF12677.7 AIC16992.1 - 1.9 8.4 0.1 1.9 8.4 0.1 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF3797) Mu-like_Com PF10122.9 AIC16992.1 - 3 7.4 9.0 7.7 6.1 0.1 3.4 3 1 0 3 3 3 0 Mu-like prophage protein Com zinc_ribbon_15 PF17032.5 AIC16992.1 - 5.7 7.8 12.3 13 6.6 2.3 2.8 1 1 1 2 2 2 0 zinc-ribbon family Nudix_N_2 PF14803.6 AIC16992.1 - 10 6.2 16.8 8.3 6.4 5.3 4.2 3 2 0 3 3 3 0 Nudix N-terminal RNA_pol_L_2 PF13656.6 AIC16993.1 - 1.7e-13 50.2 0.0 2.1e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain LGFP PF08310.11 AIC16994.1 - 0.075 13.6 0.2 12 6.5 0.1 2.5 2 0 0 2 2 2 0 LGFP repeat TPR_1 PF00515.28 AIC16995.1 - 1.8e-07 30.7 0.1 6.9e-07 28.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 AIC16995.1 - 3e-06 26.9 0.2 9.1e-06 25.4 0.0 2.0 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 AIC16995.1 - 0.00016 21.6 0.0 0.00054 20.0 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 AIC16995.1 - 0.00021 21.7 0.1 0.00049 20.5 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 AIC16995.1 - 0.0004 20.5 0.0 0.0011 19.1 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 AIC16995.1 - 0.00088 18.9 0.1 0.0052 16.4 0.0 2.2 2 0 0 2 2 2 1 TPR repeat TPR_12 PF13424.6 AIC16995.1 - 0.0017 18.6 0.0 0.0062 16.8 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Coatomer_E PF04733.14 AIC16995.1 - 0.0025 17.3 0.2 0.0064 16.0 0.1 1.6 1 1 1 2 2 2 1 Coatomer epsilon subunit TPR_7 PF13176.6 AIC16995.1 - 0.0026 17.7 0.3 0.0087 16.0 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 AIC16995.1 - 0.005 17.6 0.0 0.015 16.1 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat RICH PF05062.12 AIC16995.1 - 0.006 16.9 1.2 0.013 15.8 1.2 1.5 1 0 0 1 1 1 1 RICH domain TPR_16 PF13432.6 AIC16995.1 - 0.031 14.9 0.0 0.065 13.9 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF87 PF01935.17 AIC16995.1 - 0.06 13.4 1.1 0.082 13.0 1.1 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain HTH_45 PF14947.6 AIC16998.1 - 1.7e-10 40.7 0.0 2e-10 40.5 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIC16999.1 - 2.9e-15 55.9 0.0 5.3e-15 55.1 0.0 1.4 1 0 0 1 1 1 1 MarR family MarR_2 PF12802.7 AIC16999.1 - 1.2e-08 34.7 0.0 1.9e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 MarR family HTH_27 PF13463.6 AIC16999.1 - 1.6e-07 31.7 0.0 3.9e-07 30.5 0.0 1.6 1 0 0 1 1 1 1 Winged helix DNA-binding domain TrmB PF01978.19 AIC16999.1 - 5.8e-05 22.9 0.0 0.0001 22.1 0.0 1.4 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB TFIIE_alpha PF02002.17 AIC16999.1 - 0.0016 18.2 0.2 0.0034 17.2 0.1 1.5 1 1 0 2 2 2 1 TFIIE alpha subunit PadR PF03551.14 AIC16999.1 - 0.0024 17.8 0.0 0.0045 16.9 0.0 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Rrf2 PF02082.20 AIC16999.1 - 0.018 15.4 0.0 0.048 14.0 0.0 1.7 1 0 0 1 1 1 0 Transcriptional regulator HTH_Crp_2 PF13545.6 AIC16999.1 - 0.033 14.2 0.1 0.068 13.2 0.1 1.6 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain Fe_dep_repress PF01325.19 AIC16999.1 - 0.071 13.3 0.0 0.19 11.9 0.0 1.7 2 0 0 2 2 2 0 Iron dependent repressor, N-terminal DNA binding domain DUF501 PF04417.12 AIC16999.1 - 0.12 12.2 0.1 0.45 10.3 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF501) FeoC PF09012.10 AIC16999.1 - 0.15 12.2 0.1 0.47 10.6 0.0 1.9 2 0 0 2 2 2 0 FeoC like transcriptional regulator MFS_1 PF07690.16 AIC17000.1 - 1.7e-35 122.6 57.5 4.7e-29 101.4 29.5 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Radical_SAM PF04055.21 AIC17001.1 - 1.1e-12 48.7 0.1 1.7e-12 48.1 0.1 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Fer4_12 PF13353.6 AIC17001.1 - 0.0079 16.5 0.1 0.019 15.2 0.1 1.6 1 0 0 1 1 1 1 4Fe-4S single cluster domain Archaeal_AmoA PF12942.7 AIC17003.1 - 7.4e-117 387.6 17.1 8.9e-117 387.3 17.1 1.1 1 0 0 1 1 1 1 Archaeal ammonia monooxygenase subunit A (AmoA) DUF3267 PF11667.8 AIC17005.1 - 0.09 13.1 0.5 0.2 12.0 0.5 1.6 1 0 0 1 1 1 0 Putative zincin peptidase lci PF12197.8 AIC17005.1 - 0.095 12.5 0.0 0.29 10.9 0.0 1.8 1 0 0 1 1 1 0 Bacillus cereus group antimicrobial protein Flp_Fap PF04964.14 AIC17005.1 - 2.3 8.1 7.6 1.3 9.0 1.3 2.5 2 0 0 2 2 2 0 Flp/Fap pilin component SGTA_dimer PF16546.5 AIC17009.1 - 0.065 13.0 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Homodimerisation domain of SGTA UDPG_MGDP_dh_N PF03721.14 AIC17010.1 - 3.9e-33 114.6 0.0 3.3e-32 111.6 0.0 2.0 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 AIC17010.1 - 6.7e-23 80.7 0.0 1.2e-22 79.9 0.0 1.4 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain UDPG_MGDP_dh_C PF03720.15 AIC17010.1 - 2.9e-22 79.1 0.0 2.2e-21 76.2 0.0 2.1 2 0 0 2 2 2 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NAD_Gly3P_dh_N PF01210.23 AIC17010.1 - 3e-05 24.1 0.0 0.36 10.8 0.0 2.5 2 0 0 2 2 2 2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 2-Hacid_dh_C PF02826.19 AIC17010.1 - 3.4e-05 23.3 0.2 0.0018 17.6 0.0 2.3 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 AIC17010.1 - 0.00033 20.6 0.0 0.0034 17.3 0.0 2.1 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 AIC17010.1 - 0.001 19.6 0.4 2 9.1 0.0 3.5 3 1 0 3 3 3 1 NADP oxidoreductase coenzyme F420-dependent TrkA_N PF02254.18 AIC17010.1 - 0.0012 19.1 0.1 0.069 13.4 0.0 2.5 2 0 0 2 2 2 1 TrkA-N domain NAD_binding_2 PF03446.15 AIC17010.1 - 0.0027 17.9 0.1 0.018 15.2 0.0 2.5 3 1 0 3 3 3 1 NAD binding domain of 6-phosphogluconate dehydrogenase AlaDh_PNT_C PF01262.21 AIC17010.1 - 0.018 14.4 0.2 0.035 13.4 0.2 1.6 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain NAD_binding_7 PF13241.6 AIC17010.1 - 0.062 13.7 0.2 1.8 9.1 0.0 2.4 2 0 0 2 2 2 0 Putative NAD(P)-binding Methyltransf_31 PF13847.6 AIC17010.1 - 0.095 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain ThiF PF00899.21 AIC17010.1 - 0.11 11.8 2.1 0.7 9.2 0.4 2.4 2 0 0 2 2 2 0 ThiF family Phage_holin_3_6 PF07332.11 AIC17011.1 - 0.0028 17.7 3.4 0.0033 17.4 3.4 1.1 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III LapA_dom PF06305.11 AIC17011.1 - 0.0086 15.9 3.4 1.2 9.0 0.8 2.1 2 0 0 2 2 2 2 Lipopolysaccharide assembly protein A domain Gram_pos_anchor PF00746.21 AIC17011.1 - 0.05 13.5 3.3 0.05 13.5 3.3 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif IF-2B PF01008.17 AIC17012.1 - 4.4e-91 305.0 0.0 5.2e-91 304.7 0.0 1.0 1 0 0 1 1 1 1 Initiation factor 2 subunit family FeS_assembly_P PF01883.19 AIC17013.1 - 2.6e-18 66.0 0.0 5.4e-18 64.9 0.0 1.5 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein PqqD PF05402.12 AIC17013.1 - 5.7e-09 36.1 0.1 1e-08 35.4 0.1 1.4 1 0 0 1 1 1 1 Coenzyme PQQ synthesis protein D (PqqD) HGD-D PF06050.13 AIC17013.1 - 0.085 12.6 0.0 0.15 11.8 0.0 1.6 1 1 1 2 2 2 0 2-hydroxyglutaryl-CoA dehydratase, D-component Methyltransf_4 PF02390.17 AIC17014.1 - 2.2e-09 37.0 0.0 2.8e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_25 PF13649.6 AIC17014.1 - 1.2e-05 25.9 0.0 2e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC17014.1 - 2.5e-05 24.8 0.0 5.5e-05 23.7 0.0 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC17014.1 - 0.0047 16.7 0.0 0.0056 16.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC17014.1 - 0.012 16.4 0.0 0.021 15.6 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_33 PF10017.9 AIC17014.1 - 0.02 14.1 0.0 0.027 13.6 0.0 1.1 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent MetW PF07021.12 AIC17014.1 - 0.024 14.2 0.0 0.036 13.7 0.0 1.2 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW HTH_45 PF14947.6 AIC17015.1 - 2.5e-11 43.4 0.0 3e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF1495 PF07381.11 AIC17015.1 - 0.085 12.7 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain (DUF1495) DUF4364 PF14277.6 AIC17015.1 - 0.13 12.0 0.0 0.5 10.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4364) Bactofilin PF04519.13 AIC17016.1 - 1.7e-07 31.5 38.5 0.015 15.6 0.1 5.1 1 1 5 6 6 6 6 Polymer-forming cytoskeletal FapA PF03961.13 AIC17016.1 - 6.9e-06 24.9 24.9 0.0013 17.4 12.2 3.1 1 1 1 2 2 2 2 Flagellar Assembly Protein A MFS_1 PF07690.16 AIC17017.1 - 3.3e-58 197.3 71.9 8.1e-51 173.0 48.9 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 AIC17017.1 - 1.5e-08 33.6 41.3 1.3e-06 27.2 11.6 3.2 1 1 1 3 3 3 2 MFS/sugar transport protein MFS_1_like PF12832.7 AIC17017.1 - 2.1e-07 30.1 28.6 3.3e-05 22.9 28.5 2.4 1 1 0 1 1 1 1 MFS_1 like family MFS_4 PF06779.14 AIC17017.1 - 8e-06 25.4 43.6 1.7e-05 24.3 17.6 2.0 1 1 1 2 2 2 2 Uncharacterised MFS-type transporter YbfB FMN_red PF03358.15 AIC17019.1 - 2.4e-27 95.6 0.0 2.9e-27 95.3 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 AIC17019.1 - 2.3e-11 43.8 0.0 3.1e-11 43.4 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold Usp PF00582.26 AIC17019.1 - 0.0011 19.4 0.2 0.002 18.7 0.2 1.3 1 0 0 1 1 1 1 Universal stress protein family Flavodoxin_5 PF12724.7 AIC17019.1 - 0.027 14.7 0.0 0.052 13.8 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin domain HTH_5 PF01022.20 AIC17020.1 - 8.4e-14 51.2 0.0 1.5e-13 50.4 0.0 1.4 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC17020.1 - 1.1e-13 51.0 0.1 1.9e-13 50.3 0.1 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 AIC17020.1 - 0.00012 21.9 0.1 0.00017 21.4 0.1 1.4 1 0 0 1 1 1 1 MarR family HxlR PF01638.17 AIC17020.1 - 0.0006 19.6 0.0 0.00081 19.2 0.0 1.3 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_Crp_2 PF13545.6 AIC17020.1 - 0.019 14.9 0.0 0.025 14.5 0.0 1.3 1 0 0 1 1 1 0 Crp-like helix-turn-helix domain TrmB PF01978.19 AIC17020.1 - 0.022 14.6 0.0 0.033 14.1 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 AIC17020.1 - 0.046 13.3 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding DUF2513 PF10711.9 AIC17020.1 - 0.077 13.3 0.0 0.11 12.8 0.0 1.3 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) HTH_34 PF13601.6 AIC17020.1 - 0.082 13.1 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain RP-C PF03428.13 AIC17020.1 - 0.09 12.4 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 Replication protein C N-terminal domain AHSA1 PF08327.11 AIC17021.1 - 9.9e-19 67.8 0.0 1.4e-18 67.3 0.0 1.2 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIC17021.1 - 5.2e-06 26.8 0.3 7.2e-06 26.3 0.3 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIC17021.1 - 0.086 13.1 0.9 0.8 9.9 0.9 2.1 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport PEGSRP PF07623.11 AIC17022.1 - 6.3e-05 22.6 0.4 0.00014 21.5 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1584) zf-FCS PF06467.14 AIC17022.1 - 0.046 13.7 8.1 0.13 12.3 8.1 1.7 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif zf-MYND PF01753.18 AIC17022.1 - 0.18 11.9 8.3 0.36 10.9 8.3 1.5 1 0 0 1 1 1 0 MYND finger HGTP_anticodon PF03129.20 AIC17023.1 - 5.3e-19 68.2 0.0 1.3e-18 66.9 0.0 1.7 2 0 0 2 2 2 1 Anticodon binding domain tRNA-synt_2b PF00587.25 AIC17023.1 - 6.2e-13 49.1 0.0 1.8e-11 44.3 0.0 2.4 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) zf-C2HE PF16278.5 AIC17023.1 - 0.075 13.5 2.8 0.11 13.0 0.1 2.4 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zinc_ribbon_15 PF17032.5 AIC17023.1 - 0.096 13.4 0.2 0.27 12.0 0.1 1.8 1 1 0 1 1 1 0 zinc-ribbon family zinc_ribbon_5 PF13719.6 AIC17023.1 - 0.16 11.8 0.2 0.16 11.8 0.2 2.3 3 0 0 3 3 3 0 zinc-ribbon domain Aminotran_1_2 PF00155.21 AIC17024.1 - 1.8e-60 205.0 0.0 2.1e-60 204.8 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II DegT_DnrJ_EryC1 PF01041.17 AIC17024.1 - 1.2e-05 24.8 0.0 3.5e-05 23.3 0.0 1.6 2 0 0 2 2 2 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 AIC17024.1 - 6.5e-05 22.0 0.0 0.00012 21.1 0.0 1.4 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AIC17024.1 - 0.0012 18.2 0.0 0.0024 17.2 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 AIC17024.1 - 0.0028 16.2 0.0 0.0044 15.6 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Rad60-SLD_2 PF13881.6 AIC17025.1 - 0.042 13.9 0.1 0.07 13.2 0.1 1.6 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF308 PF03729.13 AIC17026.1 - 0.0014 18.9 3.4 0.087 13.2 0.3 2.8 2 1 1 3 3 3 2 Short repeat of unknown function (DUF308) Gram_pos_anchor PF00746.21 AIC17026.1 - 0.0026 17.7 0.5 1.8 8.6 0.5 2.3 2 0 0 2 2 2 2 LPXTG cell wall anchor motif Phage_holin_3_6 PF07332.11 AIC17026.1 - 0.0061 16.6 0.0 0.0086 16.1 0.0 1.2 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III ATP-synt_Z PF16594.5 AIC17026.1 - 0.0094 15.4 0.0 2 7.9 0.0 2.3 2 0 0 2 2 2 2 Putative AtpZ or ATP-synthase-associated BacA PF02673.18 AIC17026.1 - 0.019 14.7 0.0 0.027 14.2 0.0 1.4 1 1 0 1 1 1 0 Bacitracin resistance protein BacA TctB PF07331.11 AIC17026.1 - 0.024 14.9 0.3 0.17 12.2 1.0 1.8 1 1 1 2 2 2 0 Tripartite tricarboxylate transporter TctB family Pox_A14 PF05767.12 AIC17026.1 - 0.031 14.4 0.9 0.15 12.2 0.9 1.9 1 1 0 1 1 1 0 Poxvirus virion envelope protein A14 DUF4731 PF15875.5 AIC17026.1 - 3.8 7.8 4.7 13 6.1 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4731) F420_oxidored PF03807.17 AIC17027.1 - 3.9e-14 53.0 0.0 7.2e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 AIC17027.1 - 0.00054 19.0 0.1 0.00085 18.4 0.1 1.4 1 1 0 1 1 1 1 Prephenate dehydrogenase NAD_Gly3P_dh_N PF01210.23 AIC17027.1 - 0.0012 18.8 0.0 0.0016 18.5 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus 3HCDH_N PF02737.18 AIC17027.1 - 0.16 11.9 0.0 0.31 10.9 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain His_Phos_1 PF00300.22 AIC17028.1 - 1.1e-47 162.3 0.0 1.2e-47 162.2 0.0 1.0 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) Yip1 PF04893.17 AIC17029.1 - 0.002 17.9 1.9 0.0024 17.6 1.9 1.0 1 0 0 1 1 1 1 Yip1 domain Virul_fac_BrkB PF03631.15 AIC17029.1 - 0.017 14.7 2.5 0.021 14.5 2.5 1.0 1 0 0 1 1 1 0 Virulence factor BrkB TNFR_16_TM PF18422.1 AIC17029.1 - 0.026 14.5 0.1 0.053 13.5 0.1 1.6 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF5367 PF17329.2 AIC17029.1 - 0.03 14.4 2.0 0.073 13.2 0.2 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5367) FeoB_associated PF12669.7 AIC17029.1 - 0.031 14.7 1.2 0.069 13.6 0.1 1.9 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein LapA_dom PF06305.11 AIC17029.1 - 0.04 13.7 0.1 0.04 13.7 0.1 1.6 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Baculo_E56 PF04639.12 AIC17029.1 - 0.46 9.7 4.6 0.4 9.9 4.0 1.3 1 1 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope COX2 PF00116.20 AIC17030.1 - 1.1e-17 64.1 0.3 3.2e-14 52.9 0.0 2.1 1 1 1 2 2 2 2 Cytochrome C oxidase subunit II, periplasmic domain Cupredoxin_1 PF13473.6 AIC17030.1 - 0.0017 18.4 0.0 0.0023 18.0 0.0 1.2 1 0 0 1 1 1 1 Cupredoxin-like domain COX1 PF00115.20 AIC17031.1 - 5.6e-132 440.7 66.3 6.4e-132 440.5 66.3 1.0 1 0 0 1 1 1 1 Cytochrome C and Quinol oxidase polypeptide I Cupredoxin_1 PF13473.6 AIC17032.1 - 5e-11 42.6 0.0 1.9e-05 24.7 0.0 2.7 2 1 0 2 2 2 2 Cupredoxin-like domain Copper-bind PF00127.20 AIC17032.1 - 2e-09 37.8 0.0 6.1e-05 23.4 0.0 2.3 2 0 0 2 2 2 2 Copper binding proteins, plastocyanin/azurin family COX15-CtaA PF02628.15 AIC17033.1 - 2.1e-21 76.4 13.1 9.4e-14 51.2 5.6 2.0 1 1 1 2 2 2 2 Cytochrome oxidase assembly protein DUF1453 PF07301.11 AIC17033.1 - 0.009 16.0 4.1 0.009 16.0 4.1 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF1453) GspL_C PF12693.7 AIC17033.1 - 0.055 13.3 0.2 0.094 12.6 0.2 1.3 1 0 0 1 1 1 0 GspL periplasmic domain Cytochrom_B561 PF03188.16 AIC17033.1 - 0.33 11.1 8.1 2.2 8.4 8.1 2.0 1 1 0 1 1 1 0 Eukaryotic cytochrome b561 HCV_NS4a PF01006.20 AIC17033.1 - 1.5 8.6 6.4 18 5.2 0.9 3.0 3 0 0 3 3 3 0 Hepatitis C virus non-structural protein NS4a DUF4079 PF13301.6 AIC17034.1 - 0.54 10.4 6.2 0.32 11.2 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF4079) COX6C PF02937.15 AIC17034.1 - 2.2 8.5 5.7 1.4 9.1 0.8 3.0 3 1 0 3 3 3 0 Cytochrome c oxidase subunit VIc Phage_holin_3_3 PF16083.5 AIC17034.1 - 6 7.1 9.9 0.77 9.9 2.7 3.1 3 1 0 3 3 3 0 LydA holin phage, holin superfamily III Fe-ADH PF00465.19 AIC17035.1 - 2e-49 168.4 0.0 7.1e-49 166.6 0.0 1.7 1 1 1 2 2 2 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 AIC17035.1 - 9.3e-16 58.3 0.0 1.2e-15 57.9 0.0 1.2 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase PFK PF00365.20 AIC17035.1 - 0.014 14.7 0.0 0.021 14.1 0.0 1.2 1 0 0 1 1 1 0 Phosphofructokinase DHQ_synthase PF01761.20 AIC17035.1 - 0.071 12.3 0.0 6.9 5.7 0.0 2.2 2 0 0 2 2 2 0 3-dehydroquinate synthase Polyketide_cyc2 PF10604.9 AIC17036.1 - 3.8e-10 40.2 0.0 4.8e-10 39.9 0.0 1.1 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIC17036.1 - 2.8e-07 30.8 0.0 4.4e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport AHSA1 PF08327.11 AIC17036.1 - 1.7e-06 28.3 0.0 2.4e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein TetR_N PF00440.23 AIC17037.1 - 9.5e-17 60.5 0.4 2.1e-16 59.4 0.2 1.7 2 0 0 2 2 2 1 Bacterial regulatory proteins, tetR family TetR_C_6 PF13977.6 AIC17037.1 - 5.5e-12 45.9 0.0 1.5e-11 44.5 0.0 1.7 1 1 0 1 1 1 1 BetI-type transcriptional repressor, C-terminal TetR_C_7 PF14246.6 AIC17037.1 - 1.3e-06 28.4 0.1 2e-05 24.6 0.0 2.2 2 0 0 2 2 2 1 AefR-like transcriptional repressor, C-terminal domain TetR_C_17 PF17922.1 AIC17037.1 - 3.3e-05 23.9 2.4 0.00015 21.8 0.1 2.4 2 1 1 3 3 3 1 Tetracyclin repressor-like, C-terminal domain TetR_C_11 PF16859.5 AIC17037.1 - 0.00041 20.7 0.0 0.0016 18.7 0.0 2.0 2 1 1 3 3 3 1 Tetracyclin repressor-like, C-terminal domain TetR_C_31 PF17940.1 AIC17037.1 - 0.00058 20.0 0.0 0.0014 18.8 0.0 1.6 1 1 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain TetR_C_2 PF08361.11 AIC17037.1 - 0.00065 19.8 0.2 0.002 18.2 0.0 1.8 2 0 0 2 2 2 1 MAATS-type transcriptional repressor, C-terminal region Coat_F PF07875.12 AIC17037.1 - 0.013 15.7 0.3 1.2 9.4 0.0 2.5 2 0 0 2 2 2 0 Coat F domain TetR_C_29 PF17938.1 AIC17037.1 - 0.038 14.1 0.0 0.058 13.5 0.0 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TetR_C_36 PF18598.1 AIC17037.1 - 0.044 13.7 0.0 0.28 11.2 0.0 2.0 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HTH_Tnp_1_2 PF13022.6 AIC17037.1 - 0.047 13.8 0.6 0.14 12.3 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix of insertion element transposase CPP1-like PF11833.8 AIC17039.1 - 0.075 12.7 0.2 0.075 12.7 0.2 2.8 2 1 0 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2231 PF09990.9 AIC17039.1 - 2.6 8.5 10.7 4.3 7.8 0.5 3.0 3 1 0 3 3 3 0 Predicted membrane protein (DUF2231) Phage_holin_2_4 PF16082.5 AIC17039.1 - 7.9 6.3 6.0 5.9 6.7 2.5 2.5 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like Methyltransf_25 PF13649.6 AIC17041.1 - 2.1e-13 50.8 0.0 9.4e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC17041.1 - 7.1e-12 45.8 0.0 3.1e-10 40.6 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 AIC17041.1 - 7.5e-10 38.5 0.0 7.1e-09 35.3 0.0 2.0 2 0 0 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_31 PF13847.6 AIC17041.1 - 4e-09 36.5 0.0 9.9e-09 35.2 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC17041.1 - 5.9e-07 30.2 0.0 9.3e-07 29.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC17041.1 - 8.3e-07 29.0 0.0 1.6e-06 28.1 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 AIC17041.1 - 0.00086 19.0 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Ribosomal_L40e PF01020.17 AIC17045.1 - 0.0014 18.5 7.6 0.0016 18.3 7.6 1.1 1 0 0 1 1 1 1 Ribosomal L40e family DZR PF12773.7 AIC17045.1 - 0.016 15.2 1.1 0.019 15.0 1.1 1.2 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 AIC17045.1 - 0.02 14.6 1.8 0.028 14.1 1.8 1.3 1 0 0 1 1 1 0 zinc-ribbon domain PocR PF10114.9 AIC17045.1 - 0.023 14.5 0.9 0.024 14.4 0.9 1.0 1 0 0 1 1 1 0 Sensory domain found in PocR Ephrin PF00812.17 AIC17045.1 - 0.031 14.3 0.3 0.034 14.1 0.3 1.1 1 0 0 1 1 1 0 Ephrin DUF2024 PF09630.10 AIC17045.1 - 0.056 13.3 0.4 0.062 13.2 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) HEM4 PF02602.15 AIC17050.1 - 7.8e-41 139.9 0.9 9.1e-41 139.7 0.9 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD NMT1 PF09084.11 AIC17050.1 - 0.076 12.9 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 NMT1/THI5 like TP_methylase PF00590.20 AIC17051.1 - 4.6e-49 167.2 0.3 5.3e-49 167.0 0.3 1.0 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases DEC-1_C PF04626.13 AIC17051.1 - 0.0092 16.4 0.1 0.02 15.3 0.1 1.5 1 0 0 1 1 1 1 Dec-1 protein, C terminal region Porphobil_deam PF01379.20 AIC17052.1 - 4.4e-72 241.9 0.2 5.7e-72 241.5 0.2 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 AIC17052.1 - 1.3e-16 60.7 0.1 3.7e-16 59.3 0.1 1.8 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain LysR_substrate PF03466.20 AIC17052.1 - 0.00013 21.4 0.0 0.051 12.9 0.0 3.2 3 0 0 3 3 3 1 LysR substrate binding domain DUF4258 PF14076.6 AIC17052.1 - 0.13 12.7 0.0 0.39 11.1 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4258) Aminotran_3 PF00202.21 AIC17053.1 - 1.4e-63 215.0 0.0 1.8e-63 214.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 AIC17053.1 - 3e-09 36.5 0.0 4.4e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF3108 PF11306.8 AIC17055.1 - 0.0053 16.8 0.1 0.016 15.2 0.1 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF3108) EVE PF01878.18 AIC17056.1 - 6.1e-42 143.1 0.2 6.9e-42 142.9 0.2 1.0 1 0 0 1 1 1 1 EVE domain GTF2I PF02946.14 AIC17056.1 - 0.16 12.1 0.1 3.1 7.9 0.0 2.2 2 0 0 2 2 2 0 GTF2I-like repeat TruD PF01142.18 AIC17057.1 - 2.5e-94 316.4 0.0 2.9e-94 316.3 0.0 1.0 1 0 0 1 1 1 1 tRNA pseudouridine synthase D (TruD) HTH_45 PF14947.6 AIC17059.1 - 7.5e-07 29.1 0.0 9.7e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Winged helix-turn-helix MarR PF01047.22 AIC17059.1 - 0.00028 20.7 0.9 0.00037 20.4 0.0 1.6 2 0 0 2 2 2 1 MarR family TrmB PF01978.19 AIC17059.1 - 0.014 15.3 0.0 0.026 14.4 0.0 1.4 2 0 0 2 2 2 0 Sugar-specific transcriptional regulator TrmB PadR PF03551.14 AIC17059.1 - 0.029 14.3 0.0 0.054 13.5 0.0 1.4 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family HTH_27 PF13463.6 AIC17059.1 - 0.13 12.7 0.1 0.27 11.8 0.1 1.6 1 1 1 2 2 2 0 Winged helix DNA-binding domain PDCD2_C PF04194.13 AIC17060.1 - 0.039 14.0 0.0 0.042 13.9 0.0 1.1 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Enterotoxin_HS1 PF08090.11 AIC17060.1 - 3.4 7.7 10.0 13 5.8 0.2 2.5 2 1 0 2 2 2 0 Heat stable E.coli enterotoxin 1 Trypsin_2 PF13365.6 AIC17062.1 - 4.8e-36 124.9 0.8 1e-35 123.8 0.8 1.6 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 AIC17062.1 - 2.3e-16 59.9 0.6 2.1e-15 56.8 0.1 2.5 2 0 0 2 2 2 1 PDZ domain Trypsin PF00089.26 AIC17062.1 - 9.4e-16 58.3 0.2 2e-15 57.2 0.2 1.5 1 1 0 1 1 1 1 Trypsin PDZ_6 PF17820.1 AIC17062.1 - 4.1e-08 32.9 6.7 0.00076 19.3 0.1 3.8 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 AIC17062.1 - 1.8e-05 25.0 2.1 0.1 13.0 0.1 3.8 3 1 0 3 3 3 1 PDZ domain Tricorn_PDZ PF14685.6 AIC17062.1 - 0.0012 18.8 0.3 0.0033 17.4 0.1 1.9 2 0 0 2 2 2 1 Tricorn protease PDZ domain Peptidase_S46 PF10459.9 AIC17062.1 - 0.014 14.1 2.6 0.076 11.6 0.7 2.1 2 0 0 2 2 2 0 Peptidase S46 Peptidase_S29 PF02907.15 AIC17062.1 - 0.024 14.4 0.0 0.059 13.1 0.0 1.7 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease Cas_Cas4 PF01930.17 AIC17063.1 - 0.00065 19.8 0.1 0.00094 19.3 0.1 1.5 1 1 0 1 1 1 1 Domain of unknown function DUF83 RE_XamI PF09572.10 AIC17064.1 - 0.19 11.3 0.1 0.2 11.3 0.1 1.1 1 0 0 1 1 1 0 XamI restriction endonuclease LEA_2 PF03168.13 AIC17065.1 - 0.012 16.1 0.1 0.019 15.5 0.1 1.5 1 1 0 1 1 1 0 Late embryogenesis abundant protein DUF3712 PF12505.8 AIC17065.1 - 0.018 15.3 0.3 0.036 14.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3712) FixQ PF05545.11 AIC17067.1 - 0.11 12.5 2.2 0.25 11.3 0.0 2.7 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF3754 PF12576.8 AIC17067.1 - 0.35 10.8 3.7 1.2 9.0 3.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3754) DUF4191 PF13829.6 AIC17067.1 - 1.4 8.3 4.9 7.1 5.9 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) AA_kinase PF00696.28 AIC17068.1 - 6.8e-31 107.7 3.8 1.1e-30 107.0 3.8 1.3 1 1 0 1 1 1 1 Amino acid kinase family HD PF01966.22 AIC17069.1 - 4.4e-14 52.8 0.3 1e-13 51.6 0.3 1.7 1 0 0 1 1 1 1 HD domain HDOD PF08668.12 AIC17069.1 - 0.044 13.3 0.1 0.1 12.1 0.1 1.6 1 0 0 1 1 1 0 HDOD domain Thymidylate_kin PF02223.17 AIC17070.1 - 7e-31 107.3 0.0 8.2e-31 107.1 0.0 1.0 1 0 0 1 1 1 1 Thymidylate kinase AAA_28 PF13521.6 AIC17070.1 - 0.007 16.6 0.0 0.0085 16.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain CPT PF07931.12 AIC17070.1 - 0.04 13.7 0.0 0.094 12.6 0.0 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_18 PF13238.6 AIC17070.1 - 0.045 14.3 0.0 0.068 13.7 0.0 1.6 1 1 0 1 1 1 0 AAA domain DUF2150 PF09920.9 AIC17070.1 - 0.071 13.1 0.0 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2150) C1_2 PF03107.16 AIC17072.1 - 0.025 14.9 2.6 0.025 14.9 2.6 2.7 1 1 1 2 2 2 0 C1 domain HscB_4_cys PF18256.1 AIC17072.1 - 0.039 13.8 3.1 0.039 13.8 3.1 2.7 2 1 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif DUF1610 PF07754.11 AIC17072.1 - 0.063 13.2 5.0 0.063 13.2 5.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1610) zf_C2H2_10 PF18414.1 AIC17072.1 - 0.095 12.3 11.3 0.22 11.1 0.7 3.5 3 0 0 3 3 3 0 C2H2 type zinc-finger zf-H2C2_2 PF13465.6 AIC17072.1 - 0.2 12.1 1.7 0.2 12.1 1.7 4.0 3 2 2 5 5 5 0 Zinc-finger double domain zf-CHY PF05495.12 AIC17072.1 - 0.72 10.4 19.0 12 6.5 19.0 2.4 1 1 0 1 1 1 0 CHY zinc finger Zn_Tnp_IS1595 PF12760.7 AIC17072.1 - 0.76 9.8 19.3 46 4.1 19.3 2.8 1 1 0 1 1 1 0 Transposase zinc-ribbon domain zf-ribbon_3 PF13248.6 AIC17072.1 - 3.4 7.2 15.9 0.98 8.9 0.4 3.9 4 0 0 4 4 4 0 zinc-ribbon domain HypA PF01155.19 AIC17072.1 - 4.9 7.2 17.5 1.2 9.2 5.3 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn_Tnp_IS91 PF14319.6 AIC17072.1 - 6 7.0 17.6 0.33 11.0 6.7 2.4 1 1 1 2 2 2 0 Transposase zinc-binding domain HSP20 PF00011.21 AIC17073.1 - 1e-09 38.4 0.0 1.4e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 AIC17073.1 - 1.2e-06 27.9 0.0 2.1e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 HSP20-like domain found in ArsA ABC1 PF03109.16 AIC17074.1 - 1.2e-27 96.4 0.1 3.5e-27 94.9 0.0 1.8 2 0 0 2 2 2 1 ABC1 family Pkinase PF00069.25 AIC17074.1 - 0.00032 20.1 0.1 0.001 18.5 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain APH PF01636.23 AIC17074.1 - 0.0012 18.8 2.0 0.037 13.9 0.1 3.0 2 1 1 3 3 3 1 Phosphotransferase enzyme family CesT PF05932.13 AIC17074.1 - 0.094 12.9 0.0 0.24 11.5 0.0 1.7 1 0 0 1 1 1 0 Tir chaperone protein (CesT) family SWIRM-assoc_3 PF16498.5 AIC17074.1 - 0.16 12.2 0.1 0.5 10.6 0.0 1.8 2 0 0 2 2 2 0 SWIRM-associated domain at the C-terminal DUF4795 PF16043.5 AIC17074.1 - 0.17 11.4 0.2 0.42 10.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) ATPase_2 PF01637.18 AIC17075.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea PapG_C PF03628.13 AIC17075.1 - 0.011 15.7 1.2 15 5.5 0.0 5.6 6 0 0 6 6 6 0 PapG chaperone-binding domain RNA_helicase PF00910.22 AIC17075.1 - 0.014 15.7 0.0 0.032 14.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase SSPI PF14098.6 AIC17075.1 - 0.043 14.0 0.3 3 8.1 0.0 3.8 4 0 0 4 4 4 0 Small, acid-soluble spore protein I Rad17 PF03215.15 AIC17075.1 - 0.2 11.5 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain Glucokinase PF02685.16 AIC17075.1 - 8 5.4 5.8 4.8 6.1 0.0 3.4 5 1 1 6 6 6 0 Glucokinase Guanylate_cyc PF00211.20 AIC17076.1 - 1.4e-08 34.6 0.0 1.9e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF2715 PF10895.8 AIC17078.1 - 0.056 13.1 0.0 0.09 12.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2715) NUDIX PF00293.28 AIC17079.1 - 3e-17 62.9 0.0 3.8e-17 62.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain ComA PF02679.15 AIC17080.1 - 1.3e-59 201.6 0.1 1.7e-59 201.3 0.1 1.1 1 0 0 1 1 1 1 (2R)-phospho-3-sulfolactate synthase (ComA) MarR_2 PF12802.7 AIC17080.1 - 2.8e-05 23.9 0.0 5e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 MarR family TrmB PF01978.19 AIC17080.1 - 0.013 15.3 0.1 0.032 14.1 0.1 1.7 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB MarR PF01047.22 AIC17080.1 - 0.022 14.7 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 MarR family AP_endonuc_2 PF01261.24 AIC17080.1 - 0.11 11.9 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel NMT1_2 PF13379.6 AIC17081.1 - 5.9e-32 111.4 0.0 8e-32 110.9 0.0 1.1 1 0 0 1 1 1 1 NMT1-like family NMT1 PF09084.11 AIC17081.1 - 4e-12 46.6 0.0 5.2e-12 46.2 0.0 1.2 1 0 0 1 1 1 1 NMT1/THI5 like Phosphonate-bd PF12974.7 AIC17081.1 - 2.1e-08 34.1 0.0 9.1e-08 32.0 0.0 1.9 1 1 1 2 2 2 1 ABC transporter, phosphonate, periplasmic substrate-binding protein SBP_bac_3 PF00497.20 AIC17081.1 - 1.9e-06 27.4 0.0 0.01 15.3 0.0 2.3 1 1 1 2 2 2 2 Bacterial extracellular solute-binding proteins, family 3 NMT1_3 PF16868.5 AIC17081.1 - 0.026 14.0 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 NMT1-like family YflT PF11181.8 AIC17081.1 - 0.13 12.8 0.1 0.23 12.0 0.1 1.4 1 0 0 1 1 1 0 Heat induced stress protein YflT BPD_transp_1 PF00528.22 AIC17082.1 - 1.6e-16 60.6 18.8 1.6e-16 60.6 18.8 1.9 1 1 1 2 2 2 1 Binding-protein-dependent transport system inner membrane component CrgA PF06781.12 AIC17082.1 - 4 7.5 8.0 6.4 6.9 0.1 3.3 3 1 0 3 3 3 0 Cell division protein CrgA Pterin_4a PF01329.19 AIC17083.1 - 4.4e-30 103.7 0.2 4.9e-30 103.5 0.2 1.0 1 0 0 1 1 1 1 Pterin 4 alpha carbinolamine dehydratase MG2 PF01835.19 AIC17084.1 - 0.0036 17.7 0.1 0.012 16.1 0.1 1.9 1 0 0 1 1 1 1 MG2 domain CBM_4_9 PF02018.17 AIC17084.1 - 0.33 11.2 2.5 17 5.6 0.6 2.4 2 0 0 2 2 2 0 Carbohydrate binding domain DnaJ_CXXCXGXG PF00684.19 AIC17086.1 - 6.3e-05 23.3 10.0 9e-05 22.8 10.0 1.2 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 AIC17086.1 - 0.098 12.6 0.3 0.098 12.6 0.3 2.2 2 0 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Rieske PF00355.26 AIC17088.1 - 6.3e-10 38.9 0.0 1.1e-09 38.0 0.0 1.4 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain FMN_red PF03358.15 AIC17088.1 - 2.9e-07 30.4 0.0 3.6e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Rieske_2 PF13806.6 AIC17088.1 - 0.13 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Rieske-like [2Fe-2S] domain TPR_10 PF13374.6 AIC17089.1 - 0.1 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Rieske PF00355.26 AIC17090.1 - 4.3e-15 55.4 0.0 4.9e-15 55.2 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain TAT_ubiq PF07706.12 AIC17090.1 - 0.058 13.6 0.6 0.1 12.9 0.6 1.3 1 0 0 1 1 1 0 Aminotransferase ubiquitination site Tautomerase PF01361.21 AIC17091.1 - 6.7e-13 48.3 0.1 8.5e-13 48.0 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme Tautomerase_2 PF14552.6 AIC17091.1 - 1.3e-07 31.6 0.1 1.4e-07 31.5 0.1 1.0 1 0 0 1 1 1 1 Tautomerase enzyme CRISPR_Cas2 PF09827.9 AIC17091.1 - 0.08 13.1 0.0 0.082 13.1 0.0 1.1 1 0 0 1 1 1 0 CRISPR associated protein Cas2 Gram_pos_anchor PF00746.21 AIC17092.1 - 0.036 14.0 0.7 0.036 14.0 0.7 2.3 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Peptidase_M20 PF01546.28 AIC17093.1 - 1.5e-34 119.5 0.0 2.1e-34 119.1 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 AIC17093.1 - 1.2e-15 57.3 0.0 2.2e-15 56.5 0.0 1.4 1 0 0 1 1 1 1 Peptidase dimerisation domain DUF326 PF03860.16 AIC17094.1 - 3.3e-07 30.1 56.7 0.0039 17.1 9.4 4.3 4 0 0 4 4 4 4 Domain of Unknown Function (DUF326) Pox_P35 PF03213.14 AIC17094.1 - 1.7 7.8 5.8 1.9 7.7 5.8 1.1 1 0 0 1 1 1 0 Poxvirus P35 protein zf-C2H2 PF00096.26 AIC17095.1 - 7.8e-06 26.1 2.5 1.2e-05 25.5 2.5 1.3 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 AIC17095.1 - 0.00095 19.8 1.3 0.0016 19.1 1.3 1.4 1 0 0 1 1 1 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 AIC17095.1 - 0.51 10.9 3.9 5.2 7.7 0.1 2.3 2 0 0 2 2 2 0 Zinc-finger double domain Gram_pos_anchor PF00746.21 AIC17096.1 - 0.22 11.5 3.0 0.83 9.6 0.0 2.1 2 0 0 2 2 2 0 LPXTG cell wall anchor motif LEA_2 PF03168.13 AIC17097.1 - 0.00035 21.1 0.0 0.00058 20.4 0.0 1.4 1 0 0 1 1 1 1 Late embryogenesis abundant protein GH114_assoc PF14741.6 AIC17098.1 - 0.037 14.3 0.0 0.092 13.0 0.0 1.6 2 0 0 2 2 2 0 N-terminal glycosyl-hydrolase-114-associated domain TrmB PF01978.19 AIC17099.1 - 1.9e-10 40.5 0.1 4.7e-10 39.2 0.1 1.7 1 0 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB HTH_29 PF13551.6 AIC17099.1 - 0.019 15.0 0.2 0.11 12.5 0.0 2.2 2 0 0 2 2 2 0 Winged helix-turn helix PadR PF03551.14 AIC17099.1 - 0.044 13.7 0.0 0.17 11.8 0.0 2.0 3 0 0 3 3 3 0 Transcriptional regulator PadR-like family Penicillinase_R PF03965.16 AIC17099.1 - 0.077 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Penicillinase repressor FUR PF01475.19 AIC17099.1 - 0.19 11.9 0.0 0.56 10.4 0.0 1.7 2 0 0 2 2 2 0 Ferric uptake regulator family Aldo_ket_red PF00248.21 AIC17100.1 - 2.1e-53 181.4 0.0 2.4e-53 181.3 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family tRNA-synt_1b PF00579.25 AIC17103.1 - 3.8e-40 138.1 0.0 8.6e-40 136.9 0.0 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) DUF45 PF01863.17 AIC17104.1 - 3.4e-56 190.6 0.9 4e-56 190.4 0.9 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF45 WLM PF08325.10 AIC17104.1 - 0.00016 21.8 0.3 0.00038 20.6 0.1 1.6 2 0 0 2 2 2 1 WLM domain RRM_9 PF18444.1 AIC17104.1 - 0.043 13.7 0.0 12 5.8 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif Peptidase_M57 PF12388.8 AIC17104.1 - 0.14 11.8 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase FdtA PF05523.11 AIC17105.1 - 0.0084 15.8 0.0 0.01 15.6 0.0 1.1 1 0 0 1 1 1 1 WxcM-like, C-terminal Kinase-PolyVal PF18762.1 AIC17105.1 - 0.013 15.5 0.1 0.014 15.3 0.1 1.1 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins HSV_VP16_C PF12149.8 AIC17106.1 - 0.059 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 Herpes simplex virus virion protein 16 C terminal TP6A_N PF04406.14 AIC17107.1 - 4.2e-14 52.3 0.0 7.2e-14 51.5 0.0 1.4 1 0 0 1 1 1 1 Type IIB DNA topoisomerase GlcNAc-1_reg PF18440.1 AIC17107.1 - 0.094 13.0 0.1 0.25 11.6 0.1 1.8 1 0 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain Topo-VIb_trans PF09239.11 AIC17108.1 - 4.6e-34 117.5 0.0 1.4e-32 112.7 0.0 2.6 1 1 0 1 1 1 1 Topoisomerase VI B subunit, transducer HATPase_c PF02518.26 AIC17108.1 - 2.8e-10 40.7 0.0 1.6e-09 38.2 0.0 2.3 3 0 0 3 3 3 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 AIC17108.1 - 9.7e-07 28.7 0.0 3.4e-06 26.9 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3237 PF11578.8 AIC17109.1 - 0.077 12.8 0.0 0.082 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3237) Rod_cone_degen PF15201.6 AIC17109.1 - 0.092 12.9 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Progressive rod-cone degeneration PQ-loop PF04193.14 AIC17110.1 - 3.5e-09 36.3 1.0 3.5e-09 36.3 1.0 1.7 2 0 0 2 2 2 1 PQ loop repeat MtN3_slv PF03083.16 AIC17110.1 - 1.7e-06 28.0 0.8 2.5e-06 27.4 0.8 1.3 1 0 0 1 1 1 1 Sugar efflux transporter for intercellular exchange LAB_N PF07578.11 AIC17110.1 - 0.0023 17.9 0.3 0.0038 17.3 0.3 1.4 1 0 0 1 1 1 1 Lipid A Biosynthesis N-terminal domain FtsX PF02687.21 AIC17110.1 - 0.13 12.7 2.6 0.2 12.1 2.6 1.5 1 1 0 1 1 1 0 FtsX-like permease family DHO_dh PF01180.21 AIC17113.1 - 1e-34 120.1 0.0 1.2e-34 119.9 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 AIC17113.1 - 0.0055 16.1 0.0 0.0083 15.6 0.0 1.2 1 0 0 1 1 1 1 Nitronate monooxygenase FMN_dh PF01070.18 AIC17113.1 - 0.0087 15.1 0.0 0.014 14.5 0.0 1.2 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Radical_SAM PF04055.21 AIC17114.1 - 1.5e-08 35.2 0.0 3.4e-08 34.1 0.0 1.6 1 0 0 1 1 1 1 Radical SAM superfamily TrbH PF07283.11 AIC17115.1 - 0.0028 17.8 0.1 0.0033 17.6 0.1 1.1 1 0 0 1 1 1 1 Conjugal transfer protein TrbH Qua1 PF16274.5 AIC17115.1 - 0.25 11.2 0.1 0.25 11.2 0.1 1.8 2 0 0 2 2 2 0 Qua1 domain HD PF01966.22 AIC17116.1 - 4.9e-17 62.3 0.2 7.4e-17 61.7 0.2 1.3 1 0 0 1 1 1 1 HD domain MIOX PF05153.15 AIC17116.1 - 0.036 13.6 0.0 0.074 12.6 0.0 1.4 1 0 0 1 1 1 0 Myo-inositol oxygenase Monooxygenase_B PF04744.12 AIC17117.1 - 5.6e-14 51.8 0.0 1e-13 50.9 0.0 1.4 1 1 0 1 1 1 1 Monooxygenase subunit B protein DUF5107 PF17128.4 AIC17117.1 - 0.11 11.7 0.0 0.15 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5107) tRNA_anti-like PF12869.7 AIC17117.1 - 0.12 12.0 0.1 0.54 9.9 0.0 1.9 2 0 0 2 2 2 0 tRNA_anti-like BsuPI PF12690.7 AIC17117.1 - 0.15 12.1 0.0 2.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Intracellular proteinase inhibitor Rad51 PF08423.11 AIC17118.1 - 1.5e-88 296.4 0.2 1.9e-88 296.0 0.2 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 AIC17118.1 - 4.9e-12 45.9 0.2 6.8e-12 45.4 0.2 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 AIC17118.1 - 6.5e-09 35.5 0.6 1.5e-08 34.3 0.6 1.6 1 1 0 1 1 1 1 KaiC AAA_25 PF13481.6 AIC17118.1 - 2.4e-05 24.0 0.0 4.1e-05 23.3 0.0 1.3 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 AIC17118.1 - 0.0017 18.9 0.1 0.0065 17.0 0.1 2.1 2 0 0 2 2 2 1 Helix-hairpin-helix domain AAA_24 PF13479.6 AIC17118.1 - 0.0044 16.8 0.0 0.0072 16.1 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cdd1 PF11731.8 AIC17118.1 - 0.019 15.2 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 Pathogenicity locus AAA_22 PF13401.6 AIC17118.1 - 0.039 14.2 0.0 0.094 13.0 0.1 1.7 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 AIC17118.1 - 0.045 14.3 0.0 1.2 9.6 0.0 2.2 2 0 0 2 2 2 0 ABC transporter DNA_pol_lambd_f PF10391.9 AIC17118.1 - 0.13 12.2 0.0 0.73 9.7 0.0 2.2 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda Ribosomal_L21e PF01157.18 AIC17119.1 - 5e-19 68.0 2.1 5.7e-19 67.8 2.1 1.0 1 0 0 1 1 1 1 Ribosomal protein L21e SH3_13 PF18335.1 AIC17119.1 - 0.019 14.7 0.2 0.056 13.3 0.1 1.8 1 1 1 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain DUF4537 PF15057.6 AIC17119.1 - 0.1 12.6 0.0 0.12 12.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4537) RNA_pol_Rpb4 PF03874.16 AIC17120.1 - 8.1e-08 32.6 0.4 1.6e-07 31.6 0.4 1.5 1 1 0 1 1 1 1 RNA polymerase Rpb4 Bse634I PF07832.11 AIC17120.1 - 0.00068 19.1 0.2 0.00075 18.9 0.2 1.0 1 0 0 1 1 1 1 Cfr10I/Bse634I restriction endonuclease DUF2624 PF11116.8 AIC17120.1 - 0.027 15.3 2.0 0.98 10.4 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2624) DUF1869 PF08956.10 AIC17120.1 - 0.044 13.7 0.7 4.5 7.3 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1869) DUF655 PF04919.12 AIC17121.1 - 8.1e-38 130.2 0.3 8.6e-38 130.1 0.3 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF655) HHH_6 PF14579.6 AIC17121.1 - 7e-06 26.2 0.0 8.8e-06 25.9 0.0 1.4 1 1 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.7 AIC17121.1 - 0.005 17.1 0.1 0.011 15.9 0.0 1.7 1 1 0 1 1 1 1 Helix-hairpin-helix motif Transposase_20 PF02371.16 AIC17121.1 - 0.15 12.4 0.0 0.21 11.9 0.0 1.4 1 0 0 1 1 1 0 Transposase IS116/IS110/IS902 family RrnaAD PF00398.20 AIC17122.1 - 2.1e-39 135.2 0.0 2.6e-39 134.9 0.0 1.1 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 AIC17122.1 - 2.5e-05 24.9 0.1 6.8e-05 23.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC17122.1 - 0.00032 20.5 0.0 0.00042 20.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC17122.1 - 0.00059 20.4 0.1 0.0018 18.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain PCMT PF01135.19 AIC17122.1 - 0.00075 19.3 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 AIC17122.1 - 0.015 15.1 0.0 0.032 14.1 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain GCD14 PF08704.10 AIC17122.1 - 0.021 14.5 0.0 0.087 12.5 0.0 1.9 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Cons_hypoth95 PF03602.15 AIC17122.1 - 0.077 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 AIC17123.1 - 1e-07 31.7 0.0 2.5e-07 30.4 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 AIC17123.1 - 2.1e-06 28.4 0.1 6.2e-06 26.8 0.1 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC17123.1 - 8.3e-06 26.4 0.1 1.5e-05 25.5 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 AIC17123.1 - 0.007 17.1 0.1 0.016 15.9 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 AIC17123.1 - 0.051 13.4 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain N6-adenineMlase PF10237.9 AIC17123.1 - 0.077 12.8 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase Eco57I PF07669.11 AIC17123.1 - 0.078 13.5 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 Eco57I restriction-modification methylase UPF0020 PF01170.18 AIC17123.1 - 0.17 11.5 0.0 0.5 10.0 0.0 1.8 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Iso_dh PF00180.20 AIC17124.1 - 2.7e-79 266.9 0.0 3.3e-79 266.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Pox_TAA1 PF03295.14 AIC17124.1 - 0.12 12.2 0.0 0.88 9.5 0.0 2.2 2 0 0 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal Metallophos PF00149.28 AIC17126.1 - 5.3e-17 63.0 0.3 1.4e-16 61.6 0.3 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 AIC17126.1 - 8.6e-14 52.1 0.0 1.2e-13 51.6 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain MutL PF13941.6 AIC17126.1 - 0.13 10.9 0.0 0.19 10.3 0.0 1.2 1 0 0 1 1 1 0 MutL protein AmoC PF04896.12 AIC17128.1 - 8.5e-14 51.4 6.7 1e-13 51.1 6.7 1.1 1 0 0 1 1 1 1 Ammonia monooxygenase/methane monooxygenase, subunit C DUF2975 PF11188.8 AIC17128.1 - 0.57 10.1 4.8 1.4 8.8 4.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2975) zf-FLZ PF04570.14 AIC17129.1 - 0.033 13.7 7.6 0.039 13.4 7.6 1.1 1 0 0 1 1 1 0 zinc-finger of the FCS-type, C2-C2 CEBP_ZZ PF16366.5 AIC17129.1 - 0.035 14.4 9.3 0.034 14.4 9.3 1.1 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-AN1 PF01428.16 AIC17129.1 - 0.23 11.6 9.1 0.38 11.0 9.2 1.3 1 1 0 1 1 1 0 AN1-like Zinc finger C1_2 PF03107.16 AIC17129.1 - 0.25 11.7 11.0 1.1 9.7 11.0 1.8 1 1 0 1 1 1 0 C1 domain UPF1_Zn_bind PF09416.10 AIC17129.1 - 0.87 9.5 6.6 0.97 9.4 6.6 1.1 1 0 0 1 1 1 0 RNA helicase (UPF2 interacting domain) zf-HIT PF04438.16 AIC17129.1 - 0.92 9.4 9.6 1.5 8.7 9.6 1.5 1 1 0 1 1 1 0 HIT zinc finger zf-B_box PF00643.24 AIC17129.1 - 1.1 9.4 8.9 1.8 8.8 8.9 1.3 1 1 0 1 1 1 0 B-box zinc finger FtsX PF02687.21 AIC17130.1 - 2.9e-14 53.3 1.7 2.9e-14 53.3 1.7 3.1 3 1 0 3 3 3 1 FtsX-like permease family MacB_PCD PF12704.7 AIC17130.1 - 3e-14 53.8 2.5 3e-14 53.8 2.5 2.1 2 1 0 2 2 2 1 MacB-like periplasmic core domain PRA1 PF03208.19 AIC17130.1 - 3.3 7.3 6.0 0.61 9.7 1.8 1.8 2 0 0 2 2 2 0 PRA1 family protein NPCBM_assoc PF10633.9 AIC17131.1 - 2.6e-09 37.2 13.3 0.0019 18.4 0.1 5.2 4 1 0 4 4 4 4 NPCBM-associated, NEW3 domain of alpha-galactosidase DUF11 PF01345.18 AIC17131.1 - 7.6e-06 26.1 25.4 0.00021 21.5 2.9 5.0 5 1 1 6 6 6 2 Domain of unknown function DUF11 Protocadherin PF08374.11 AIC17131.1 - 0.0065 16.5 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Protocadherin ASH PF15780.5 AIC17131.1 - 0.018 15.2 0.6 10 6.4 0.0 3.1 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin DUF4064 PF13273.6 AIC17131.1 - 0.02 15.1 0.0 0.092 13.0 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) CARDB PF07705.11 AIC17131.1 - 0.044 14.0 9.5 0.21 11.9 0.5 3.6 2 2 1 3 3 3 0 CARDB Pilin_N PF07790.11 AIC17131.1 - 0.055 14.4 0.2 0.055 14.4 0.2 2.9 3 0 0 3 3 3 0 Archaeal Type IV pilin, N-terminal DUF4232 PF14016.6 AIC17131.1 - 0.055 13.6 9.0 0.21 11.7 4.6 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4232) DUF5305 PF17231.2 AIC17131.1 - 0.09 12.2 0.0 0.23 10.8 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5305) ABC_tran PF00005.27 AIC17132.1 - 3.1e-34 118.4 0.0 4.8e-34 117.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 AIC17132.1 - 1.2e-08 35.2 1.0 0.0027 17.6 0.0 2.1 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 AIC17132.1 - 1.3e-07 31.3 0.2 0.0034 16.9 0.0 2.2 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_29 PF13555.6 AIC17132.1 - 3.7e-05 23.4 0.1 6.7e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 AIC17132.1 - 0.00014 21.7 0.1 0.13 12.0 0.1 2.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_16 PF13191.6 AIC17132.1 - 0.00028 21.3 0.0 0.00043 20.7 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 AIC17132.1 - 0.00031 20.5 0.0 0.14 11.9 0.0 2.2 2 0 0 2 2 2 2 IstB-like ATP binding protein RsgA_GTPase PF03193.16 AIC17132.1 - 0.00041 20.3 0.1 0.00074 19.5 0.1 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 AIC17132.1 - 0.0028 17.9 0.1 0.0092 16.3 0.1 2.0 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 AIC17132.1 - 0.003 18.1 0.1 0.0049 17.4 0.1 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 AIC17132.1 - 0.0072 16.4 0.5 0.017 15.2 0.5 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_30 PF13604.6 AIC17132.1 - 0.0076 16.0 0.1 0.014 15.2 0.1 1.7 1 1 0 1 1 1 1 AAA domain NACHT PF05729.12 AIC17132.1 - 0.028 14.3 0.0 0.18 11.7 0.0 2.0 2 0 0 2 2 2 0 NACHT domain G-alpha PF00503.20 AIC17132.1 - 0.042 13.0 0.0 0.048 12.8 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_25 PF13481.6 AIC17132.1 - 0.046 13.3 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 AIC17132.1 - 0.058 12.5 0.0 0.096 11.7 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 AIC17132.1 - 0.06 13.5 0.4 0.17 12.1 0.4 2.0 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 AIC17132.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Dynamin_N PF00350.23 AIC17132.1 - 0.063 13.3 0.2 0.67 10.0 0.1 2.1 2 0 0 2 2 2 0 Dynamin family DIM PF08194.12 AIC17132.1 - 0.069 13.4 0.2 0.14 12.4 0.2 1.5 1 0 0 1 1 1 0 DIM protein NB-ARC PF00931.22 AIC17132.1 - 0.12 11.5 0.1 0.25 10.5 0.1 1.5 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 AIC17132.1 - 0.14 12.7 0.0 0.29 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 AIC17132.1 - 0.14 11.7 0.1 0.29 10.7 0.0 1.6 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_28 PF13521.6 AIC17132.1 - 0.2 11.9 0.1 0.36 11.1 0.1 1.4 1 0 0 1 1 1 0 AAA domain YHS PF04945.13 AIC17133.1 - 5.4e-13 48.8 0.9 6.4e-13 48.6 0.9 1.1 1 0 0 1 1 1 1 YHS domain Arc_trans_TRASH PF08394.10 AIC17133.1 - 1.9e-06 28.1 1.5 2.4e-06 27.8 1.5 1.1 1 0 0 1 1 1 1 Archaeal TRASH domain ATPase-cat_bd PF12156.8 AIC17133.1 - 9.1e-05 23.1 1.2 0.00011 22.8 1.2 1.0 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase CAP_GLY PF01302.25 AIC17133.1 - 0.031 14.3 0.1 0.039 14.0 0.1 1.2 1 0 0 1 1 1 0 CAP-Gly domain Asn_synthase PF00733.21 AIC17134.1 - 3.7e-35 122.2 0.2 3.3e-22 79.7 0.0 2.0 1 1 1 2 2 2 2 Asparagine synthase Arginosuc_synth PF00764.19 AIC17134.1 - 0.018 14.4 0.0 0.027 13.8 0.0 1.3 1 0 0 1 1 1 0 Arginosuccinate synthase SCF PF02404.15 AIC17134.1 - 0.15 11.4 0.0 0.56 9.5 0.0 1.8 2 0 0 2 2 2 0 Stem cell factor NAD_synthase PF02540.17 AIC17134.1 - 0.22 10.6 0.0 0.34 10.0 0.0 1.3 1 0 0 1 1 1 0 NAD synthase QueC PF06508.13 AIC17134.1 - 0.26 10.8 1.0 0.6 9.6 0.0 2.3 2 1 0 2 2 2 0 Queuosine biosynthesis protein QueC Glyoxalase_4 PF13669.6 AIC17135.1 - 5.3e-23 81.4 0.0 6.2e-23 81.2 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase PF00903.25 AIC17135.1 - 1.9e-13 50.7 0.0 2.2e-13 50.5 0.0 1.0 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 AIC17135.1 - 3.9e-08 33.6 0.0 4.3e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Glyoxalase-like domain Fmp27_SW PF10305.9 AIC17135.1 - 0.069 13.9 0.0 0.11 13.2 0.0 1.4 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain MM_CoA_mutase PF01642.22 AIC17136.1 - 2.5e-224 745.6 0.1 2.8e-224 745.4 0.1 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase Ca_bind_SSO6904 PF18249.1 AIC17136.1 - 0.13 12.6 0.0 0.45 10.9 0.0 2.0 1 0 0 1 1 1 0 Calcium binding protein SSO6904 MeaB PF03308.16 AIC17137.1 - 3.2e-81 272.3 3.1 3.8e-81 272.0 3.1 1.0 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 AIC17137.1 - 2.4e-05 24.3 0.0 0.033 14.0 0.0 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 AIC17137.1 - 0.00011 22.2 0.0 0.0028 17.6 0.0 2.7 2 1 0 2 2 2 1 RsgA GTPase cobW PF02492.19 AIC17137.1 - 0.0012 18.5 0.4 0.0062 16.1 0.4 2.2 1 1 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain MnmE_helical PF12631.7 AIC17137.1 - 0.0018 18.4 0.0 0.0023 18.1 0.0 1.4 1 1 0 1 1 1 1 MnmE helical domain MobB PF03205.14 AIC17137.1 - 0.0025 17.7 0.0 0.037 13.9 0.0 2.3 2 0 0 2 2 2 1 Molybdopterin guanine dinucleotide synthesis protein B GTP_EFTU PF00009.27 AIC17137.1 - 0.005 16.4 0.0 0.19 11.3 0.0 2.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 AIC17137.1 - 0.011 15.8 0.3 0.077 13.1 0.1 2.5 1 1 1 2 2 2 0 50S ribosome-binding GTPase AAA_30 PF13604.6 AIC17137.1 - 0.013 15.2 0.0 0.036 13.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain Troponin PF00992.20 AIC17137.1 - 0.014 15.7 2.3 0.028 14.7 2.3 1.4 1 0 0 1 1 1 0 Troponin CbiA PF01656.23 AIC17137.1 - 0.022 14.8 0.0 0.048 13.7 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 AIC17137.1 - 0.031 14.7 0.1 0.074 13.4 0.1 1.6 2 0 0 2 2 2 0 AAA ATPase domain PIF1 PF05970.14 AIC17137.1 - 0.031 13.4 0.1 0.066 12.4 0.0 1.5 2 0 0 2 2 2 0 PIF1-like helicase Ins_allergen_rp PF06757.13 AIC17137.1 - 0.039 13.9 0.0 0.065 13.2 0.0 1.3 1 0 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification ABC_tran PF00005.27 AIC17137.1 - 0.041 14.4 0.4 0.12 12.9 0.1 1.9 2 0 0 2 2 2 0 ABC transporter Ribosomal_L20 PF00453.18 AIC17137.1 - 0.048 13.7 0.1 0.098 12.8 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L20 ArsA_ATPase PF02374.15 AIC17137.1 - 0.25 10.5 2.6 0.79 8.8 0.3 2.3 2 0 0 2 2 2 0 Anion-transporting ATPase Sorb PF02208.16 AIC17138.1 - 0.043 13.7 2.8 1.3 9.0 1.6 2.2 2 0 0 2 2 2 0 Sorbin homologous domain B12-binding PF02310.19 AIC17139.1 - 2.2e-19 69.6 0.0 2.9e-19 69.3 0.0 1.1 1 0 0 1 1 1 1 B12 binding domain IlvN PF07991.12 AIC17140.1 - 2.9e-69 231.9 0.8 3.9e-69 231.4 0.8 1.2 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain IlvC PF01450.19 AIC17140.1 - 5.8e-59 198.5 0.8 9.5e-59 197.8 0.8 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, catalytic domain 2-Hacid_dh_C PF02826.19 AIC17140.1 - 1e-06 28.2 0.1 1.8e-06 27.4 0.1 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 AIC17140.1 - 1.7e-06 28.3 0.3 3.4e-06 27.3 0.3 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 AIC17140.1 - 5.7e-05 23.6 0.7 0.00014 22.4 0.7 1.7 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent AdoHcyase_NAD PF00670.21 AIC17140.1 - 0.009 16.1 0.1 0.016 15.2 0.1 1.3 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain tRNA_SAD PF07973.14 AIC17140.1 - 0.19 11.8 0.1 0.43 10.7 0.1 1.5 1 0 0 1 1 1 0 Threonyl and Alanyl tRNA synthetase second additional domain Usp PF00582.26 AIC17141.1 - 4.9e-29 101.6 0.1 5.6e-29 101.5 0.1 1.0 1 0 0 1 1 1 1 Universal stress protein family PGM_PMM_I PF02878.16 AIC17141.1 - 0.023 14.4 0.1 0.27 10.9 0.0 2.0 2 0 0 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I HPP PF04982.13 AIC17142.1 - 1.9e-32 112.0 12.9 1.9e-32 112.0 12.9 1.7 2 0 0 2 2 2 1 HPP family Yip1 PF04893.17 AIC17143.1 - 0.0002 21.2 23.1 0.00032 20.5 23.1 1.3 1 0 0 1 1 1 1 Yip1 domain Peptidase_U4 PF03419.13 AIC17143.1 - 0.0019 17.6 13.2 0.003 16.9 13.2 1.3 1 0 0 1 1 1 1 Sporulation factor SpoIIGA Phage_holin_4_2 PF04020.13 AIC17143.1 - 0.0027 18.4 16.4 0.01 16.5 2.9 2.1 1 1 1 2 2 2 2 Mycobacterial 4 TMS phage holin, superfamily IV ECF_trnsprt PF12822.7 AIC17143.1 - 0.3 11.2 17.6 0.35 11.0 17.6 1.1 1 0 0 1 1 1 0 ECF transporter, substrate-specific component DUF4229 PF14012.6 AIC17143.1 - 1.4 9.1 15.7 0.4 10.8 2.3 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF4229) DUF2070 PF09843.9 AIC17143.1 - 7.6 4.7 9.9 9.6 4.4 9.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HisKA_3 PF07730.13 AIC17144.1 - 3.6e-06 27.4 2.2 0.00059 20.3 0.1 3.2 2 1 1 3 3 3 1 Histidine kinase ApoLp-III PF07464.11 AIC17144.1 - 0.00032 20.8 10.7 0.061 13.4 5.2 2.6 1 1 1 2 2 2 2 Apolipophorin-III precursor (apoLp-III) DUF883 PF05957.13 AIC17144.1 - 0.00082 19.9 5.5 0.07 13.7 0.7 2.2 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF883) TMP_2 PF06791.13 AIC17144.1 - 0.00091 18.9 9.6 0.015 15.0 1.2 2.1 1 1 1 2 2 2 2 Prophage tail length tape measure protein YtxH PF12732.7 AIC17144.1 - 0.017 15.6 13.4 1.9e+02 2.6 13.4 3.3 1 1 0 1 1 1 0 YtxH-like protein WXG100 PF06013.12 AIC17144.1 - 0.021 15.0 5.6 2.7 8.3 3.4 3.3 2 1 0 2 2 2 0 Proteins of 100 residues with WXG KxDL PF10241.9 AIC17144.1 - 0.026 14.8 3.5 0.059 13.6 1.6 2.3 1 1 0 2 2 2 0 Uncharacterized conserved protein MukF_M PF17192.4 AIC17144.1 - 0.034 13.9 2.9 1.1 9.0 0.3 2.1 1 1 1 2 2 2 0 MukF middle domain MAD PF05557.13 AIC17144.1 - 0.038 12.4 4.0 0.046 12.1 4.0 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein Phage_sheath_1C PF17482.2 AIC17144.1 - 0.067 13.2 1.1 0.81 9.7 0.5 2.5 1 1 1 2 2 2 0 Phage tail sheath C-terminal domain DUF1664 PF07889.12 AIC17144.1 - 0.093 12.8 6.4 7 6.7 5.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 AIC17144.1 - 0.11 12.5 9.5 0.91 9.5 5.5 2.4 1 1 1 2 2 2 0 Laminin Domain II DLP_helical PF18709.1 AIC17144.1 - 0.12 11.6 8.2 0.12 11.5 2.4 2.3 1 1 0 2 2 2 0 Dynamin-like helical domain TPR_MLP1_2 PF07926.12 AIC17144.1 - 0.17 11.9 6.8 0.12 12.4 3.2 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GLE1 PF07817.13 AIC17144.1 - 0.18 11.0 1.2 0.25 10.5 0.4 1.6 2 0 0 2 2 2 0 GLE1-like protein Prominin PF05478.11 AIC17144.1 - 0.19 9.7 4.6 0.47 8.3 4.6 1.6 1 1 0 1 1 1 0 Prominin DUF2250 PF10007.9 AIC17144.1 - 0.23 11.6 1.1 3.3 7.9 0.1 2.6 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2250) Syntaxin-6_N PF09177.11 AIC17144.1 - 0.27 11.8 4.6 22 5.7 4.5 2.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal DUF948 PF06103.11 AIC17144.1 - 0.32 11.3 10.0 27 5.1 6.4 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) H-kinase_dim PF02895.14 AIC17144.1 - 0.41 11.1 4.7 0.97 9.9 0.6 2.9 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain TMPIT PF07851.13 AIC17144.1 - 0.48 9.6 5.5 5.5 6.1 5.6 2.0 1 1 0 1 1 1 0 TMPIT-like protein UPF0181 PF03701.14 AIC17144.1 - 0.65 9.7 4.2 0.22 11.2 0.5 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0181) Spc7 PF08317.11 AIC17144.1 - 0.89 8.4 7.7 0.47 9.3 3.7 1.8 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF5301 PF17225.3 AIC17144.1 - 0.93 10.0 8.5 19 5.8 1.6 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5300) OmpH PF03938.14 AIC17144.1 - 2.7 8.3 10.5 0.72 10.2 3.1 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Lectin_N PF03954.14 AIC17144.1 - 3.1 7.6 4.5 44 3.8 4.5 2.1 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain Seryl_tRNA_N PF02403.22 AIC17144.1 - 3.4 7.9 9.2 18 5.6 7.2 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ADK_lid PF05191.14 AIC17146.1 - 0.054 13.5 3.0 0.084 12.9 2.2 1.8 2 0 0 2 2 2 0 Adenylate kinase, active site lid DUF2335 PF10097.9 AIC17146.1 - 2.2 8.3 4.9 6.8 6.7 0.5 2.4 2 0 0 2 2 2 0 Predicted membrane protein (DUF2335) HTH_5 PF01022.20 AIC17147.1 - 1.9e-14 53.2 0.8 3.9e-14 52.3 0.8 1.5 1 0 0 1 1 1 1 Bacterial regulatory protein, arsR family HTH_20 PF12840.7 AIC17147.1 - 4.5e-13 49.1 1.0 7.6e-13 48.3 1.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 AIC17147.1 - 2.1e-08 33.9 0.1 3.5e-08 33.2 0.1 1.4 1 0 0 1 1 1 1 MarR family HTH_24 PF13412.6 AIC17147.1 - 5.5e-07 29.0 0.1 9.3e-07 28.3 0.1 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 AIC17147.1 - 2.3e-05 24.2 0.4 4.9e-05 23.2 0.4 1.5 1 0 0 1 1 1 1 MarR family HTH_11 PF08279.12 AIC17147.1 - 7.8e-05 22.5 0.5 0.00016 21.5 0.5 1.5 1 0 0 1 1 1 1 HTH domain HTH_Crp_2 PF13545.6 AIC17147.1 - 8e-05 22.5 0.4 0.00018 21.4 0.4 1.6 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain TFIIE_alpha PF02002.17 AIC17147.1 - 0.00035 20.4 0.4 0.00062 19.6 0.1 1.5 2 0 0 2 2 1 1 TFIIE alpha subunit HTH_IclR PF09339.10 AIC17147.1 - 0.00059 19.6 0.5 0.0013 18.5 0.5 1.5 1 0 0 1 1 1 1 IclR helix-turn-helix domain HTH_10 PF04967.12 AIC17147.1 - 0.0021 17.8 0.1 0.0053 16.5 0.1 1.7 1 0 0 1 1 1 1 HTH DNA binding domain Sigma70_r4 PF04545.16 AIC17147.1 - 0.0025 17.3 0.0 0.0054 16.2 0.0 1.6 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_34 PF13601.6 AIC17147.1 - 0.0034 17.5 0.1 0.0072 16.5 0.1 1.5 1 0 0 1 1 1 1 Winged helix DNA-binding domain Fe_dep_repress PF01325.19 AIC17147.1 - 0.0071 16.5 0.1 0.013 15.7 0.1 1.4 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_26 PF13443.6 AIC17147.1 - 0.0073 16.7 0.2 0.015 15.7 0.2 1.5 1 0 0 1 1 1 1 Cro/C1-type HTH DNA-binding domain Rrf2 PF02082.20 AIC17147.1 - 0.0096 16.3 0.2 0.018 15.4 0.2 1.4 1 0 0 1 1 1 1 Transcriptional regulator HTH_Tnp_ISL3 PF13542.6 AIC17147.1 - 0.011 15.2 0.2 0.026 13.9 0.2 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain of transposase family ISL3 HTH_3 PF01381.22 AIC17147.1 - 0.012 15.7 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix DprA_WH PF17782.1 AIC17147.1 - 0.012 15.7 0.3 0.021 14.9 0.3 1.3 1 0 0 1 1 1 0 DprA winged helix domain TrmB PF01978.19 AIC17147.1 - 0.017 15.0 0.0 0.028 14.3 0.0 1.4 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB HTH_28 PF13518.6 AIC17147.1 - 0.074 13.2 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain HTH_27 PF13463.6 AIC17147.1 - 0.19 12.3 0.3 0.19 12.3 0.3 1.7 2 0 0 2 2 1 0 Winged helix DNA-binding domain HTH_35 PF13693.6 AIC17147.1 - 0.24 11.4 0.1 0.24 11.4 0.1 1.7 2 0 0 2 2 2 0 Winged helix-turn-helix DNA-binding HBM PF16591.5 AIC17148.1 - 0.0047 16.4 0.8 0.3 10.5 0.0 2.1 2 0 0 2 2 2 1 Helical bimodular sensor domain DUF2203 PF09969.9 AIC17148.1 - 0.039 14.7 6.2 0.084 13.6 0.7 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) SesA PF17107.5 AIC17148.1 - 0.045 13.9 4.8 0.29 11.3 0.8 2.5 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases 4HB_MCP_1 PF12729.7 AIC17148.1 - 0.094 12.2 7.0 0.53 9.8 0.2 2.2 2 0 0 2 2 2 0 Four helix bundle sensory module for signal transduction CemA PF03040.14 AIC17148.1 - 0.1 12.5 0.9 0.86 9.5 0.2 2.0 2 0 0 2 2 2 0 CemA family Peptidase_S66C PF17676.1 AIC17148.1 - 0.12 12.9 0.3 0.28 11.7 0.1 1.6 2 0 0 2 2 2 0 LD-carboxypeptidase C-terminal domain Trimer_CC PF08954.11 AIC17148.1 - 0.31 10.6 0.1 0.31 10.6 0.1 2.3 2 0 0 2 2 2 0 Trimerisation motif eIF3_N PF09440.10 AIC17148.1 - 0.37 11.2 4.1 1.2 9.5 0.7 2.6 1 1 2 3 3 3 0 eIF3 subunit 6 N terminal domain Syntaxin-6_N PF09177.11 AIC17148.1 - 0.44 11.1 4.4 2.4 8.8 2.1 2.5 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 AIC17148.1 - 1.5 9.2 7.7 1.8e+02 2.5 7.7 2.9 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Sec8_exocyst PF04048.14 AIC17148.1 - 1.9 8.4 8.1 7.6 6.4 0.4 2.9 2 2 0 2 2 2 0 Sec8 exocyst complex component specific domain BORCS8 PF10167.9 AIC17148.1 - 3.3 7.7 7.0 1.7 8.6 0.8 2.5 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 8 Ferritin PF00210.24 AIC17150.1 - 4.1e-32 111.1 1.5 4.9e-32 110.8 1.5 1.0 1 0 0 1 1 1 1 Ferritin-like domain HrpB2 PF09487.10 AIC17150.1 - 0.032 14.7 0.4 0.42 11.1 0.1 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB2) DUF4131 PF13567.6 AIC17151.1 - 0.027 14.1 0.5 0.031 13.9 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4191 PF13829.6 AIC17151.1 - 0.032 13.6 0.6 0.033 13.5 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) DUF2613 PF11021.8 AIC17151.1 - 0.062 13.4 3.6 2.9 8.1 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2613) Picorna_P3A PF06363.11 AIC17151.1 - 0.14 12.1 2.9 0.17 11.8 0.4 1.9 1 1 1 2 2 2 0 Picornaviridae P3A protein DUF2207 PF09972.9 AIC17151.1 - 0.15 10.8 2.0 0.15 10.8 2.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5362 PF17319.2 AIC17151.1 - 0.64 9.9 8.9 0.22 11.4 5.0 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5362) Spermine_synth PF01564.17 AIC17152.1 - 8e-09 35.2 0.0 1.3e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Methyltransf_12 PF08242.12 AIC17152.1 - 0.018 15.7 0.0 0.049 14.4 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_25 PF13649.6 AIC17152.1 - 0.026 15.2 0.0 0.089 13.5 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain ADH_zinc_N PF00107.26 AIC17152.1 - 0.064 13.2 0.0 0.14 12.1 0.0 1.6 1 0 0 1 1 1 0 Zinc-binding dehydrogenase PLDc_2 PF13091.6 AIC17154.1 - 4.4e-06 26.6 1.3 0.0097 15.8 0.1 2.6 1 1 0 2 2 2 2 PLD-like domain MinC_C PF03775.16 AIC17154.1 - 0.011 15.8 0.0 0.026 14.5 0.0 1.7 1 0 0 1 1 1 0 Septum formation inhibitor MinC, C-terminal domain SseB_C PF14581.6 AIC17154.1 - 0.061 13.4 2.4 0.38 10.9 0.1 2.8 3 1 1 4 4 4 0 SseB protein C-terminal domain DUF4242 PF14026.6 AIC17155.1 - 1.2e-09 38.2 0.0 1.7e-09 37.7 0.0 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4242) DUF2795 PF11387.8 AIC17156.1 - 5.1e-06 26.6 0.0 1.4e-05 25.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2795) ATP-cone PF03477.16 AIC17156.1 - 0.047 14.3 0.1 0.12 13.0 0.0 1.7 2 0 0 2 2 2 0 ATP cone domain Putative_PNPOx PF01243.20 AIC17158.1 - 1.9e-13 50.4 0.0 3e-13 49.8 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_ox_2 PF12900.7 AIC17158.1 - 2.8e-06 27.4 0.0 3.3e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_ox_like PF16242.5 AIC17158.1 - 5e-06 26.2 0.0 6.2e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like Rieske PF00355.26 AIC17159.1 - 1.1e-15 57.3 0.0 1.3e-15 57.1 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIC17159.1 - 3.9e-06 26.7 0.0 4.8e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain MazE_antitoxin PF04014.18 AIC17159.1 - 0.022 14.7 0.3 0.039 13.9 0.3 1.3 1 0 0 1 1 1 0 Antidote-toxin recognition MazE, bacterial antitoxin Acetyltransf_1 PF00583.25 AIC17160.1 - 2.3e-10 40.7 0.0 2.9e-10 40.4 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 AIC17160.1 - 7.2e-10 39.2 0.0 1.1e-09 38.5 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 AIC17160.1 - 1.1e-09 38.3 0.0 1.5e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 AIC17160.1 - 0.0003 20.7 0.0 0.00056 19.8 0.0 1.4 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 AIC17160.1 - 0.00035 20.7 0.0 0.00058 19.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 AIC17160.1 - 0.041 14.0 0.0 0.067 13.3 0.0 1.3 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase 3-dmu-9_3-mt PF06983.13 AIC17162.1 - 1.4e-44 151.3 0.1 2.1e-44 150.8 0.1 1.2 1 0 0 1 1 1 1 3-demethylubiquinone-9 3-methyltransferase AHSA1 PF08327.11 AIC17163.1 - 2.2e-24 86.1 1.1 2.5e-24 85.9 1.1 1.0 1 0 0 1 1 1 1 Activator of Hsp90 ATPase homolog 1-like protein Polyketide_cyc2 PF10604.9 AIC17163.1 - 2.1e-06 28.0 1.1 3.9e-06 27.2 1.1 1.4 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Polyketide_cyc PF03364.20 AIC17163.1 - 0.037 14.2 0.2 0.05 13.8 0.2 1.5 1 1 0 1 1 1 0 Polyketide cyclase / dehydrase and lipid transport PCO_ADO PF07847.12 AIC17165.1 - 0.11 11.9 0.1 0.14 11.6 0.1 1.3 1 1 0 1 1 1 0 PCO_ADO HNH_5 PF14279.6 AIC17167.1 - 0.00015 21.5 0.3 0.00035 20.4 0.3 1.6 1 0 0 1 1 1 1 HNH endonuclease PsbQ PF05757.11 AIC17168.1 - 0.0039 16.9 0.2 0.0045 16.7 0.2 1.1 1 0 0 1 1 1 1 Oxygen evolving enhancer protein 3 (PsbQ) CAT_RBD PF03123.15 AIC17169.1 - 0.029 14.3 0.7 9.9 6.2 0.0 2.3 2 0 0 2 2 2 0 CAT RNA binding domain Prok-RING_4 PF14447.6 AIC17171.1 - 0.08 12.8 0.1 0.13 12.2 0.1 1.2 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-CHCC PF10276.9 AIC17171.1 - 0.084 12.9 0.6 0.084 12.9 0.6 1.6 2 0 0 2 2 2 0 Zinc-finger domain Phage_integrase PF00589.22 AIC17174.1 - 2.6e-05 24.1 0.0 0.00016 21.5 0.0 2.2 1 1 0 1 1 1 1 Phage integrase family HTH_38 PF13936.6 AIC17174.1 - 0.00075 19.2 0.3 0.0068 16.2 0.3 2.8 3 0 0 3 3 3 1 Helix-turn-helix domain RVT_connect PF06815.13 AIC17174.1 - 2.9 8.2 6.7 0.14 12.4 0.5 2.0 3 0 0 3 3 3 0 Reverse transcriptase connection domain N6_N4_Mtase PF01555.18 AIC17176.1 - 3.6e-44 151.2 0.1 4.5e-43 147.6 0.1 2.0 1 1 0 1 1 1 1 DNA methylase UPF0020 PF01170.18 AIC17176.1 - 0.0046 16.7 0.0 0.77 9.4 0.0 2.4 2 0 0 2 2 2 2 Putative RNA methylase family UPF0020 MTS PF05175.14 AIC17176.1 - 0.032 13.8 0.0 2.3 7.8 0.0 2.9 2 1 0 2 2 2 0 Methyltransferase small domain Methyltransf_15 PF09445.10 AIC17176.1 - 0.063 12.8 0.1 5.3 6.6 0.0 2.9 3 0 0 3 3 3 0 RNA cap guanine-N2 methyltransferase HEPN_Cthe2314 PF18730.1 AIC17179.1 - 7.2e-06 26.2 0.2 1e-05 25.7 0.2 1.4 1 0 0 1 1 1 1 Cthe_2314-like HEPN DUF2001 PF09393.10 AIC17179.1 - 0.14 12.1 0.0 0.23 11.4 0.0 1.3 1 0 0 1 1 1 0 Phage tail tube protein DUF1874 PF08960.10 AIC17179.1 - 0.15 12.2 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1874) HNH PF01844.23 AIC17181.1 - 0.061 13.5 2.4 0.12 12.6 2.4 1.5 1 0 0 1 1 1 0 HNH endonuclease VAPB_antitox PF02697.14 AIC17182.1 - 0.14 13.0 0.0 0.16 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative antitoxin DUF1764 PF08576.10 AIC17185.1 - 0.21 12.5 2.2 0.83 10.6 2.2 2.0 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) HEPN PF05168.14 AIC17186.1 - 1.4e-10 41.3 0.1 3.4e-10 40.1 0.1 1.7 1 0 0 1 1 1 1 HEPN domain Anti-TRAP PF15777.5 AIC17187.1 - 0.038 14.0 0.1 0.048 13.6 0.1 1.2 1 0 0 1 1 1 0 Tryptophan RNA-binding attenuator protein inhibitory protein DZR PF12773.7 AIC17189.1 - 0.0057 16.7 1.1 0.013 15.5 1.1 1.5 1 0 0 1 1 1 1 Double zinc ribbon Phage_int_SAM_4 PF13495.6 AIC17189.1 - 0.12 12.9 4.7 0.17 12.3 2.5 2.5 2 1 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain zinc_ribbon_2 PF13240.6 AIC17189.1 - 0.27 11.0 2.1 0.59 9.9 2.1 1.6 1 0 0 1 1 1 0 zinc-ribbon domain DUF2387 PF09526.10 AIC17189.1 - 0.34 11.1 4.4 1.5 9.0 4.4 2.1 1 1 0 1 1 1 0 Probable metal-binding protein (DUF2387) UPF0547 PF10571.9 AIC17189.1 - 0.86 9.7 3.3 1.8 8.7 3.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Radical_SAM PF04055.21 AIC17190.1 - 5e-10 40.0 0.4 2e-09 38.0 0.3 1.9 2 0 0 2 2 2 1 Radical SAM superfamily Fer4_12 PF13353.6 AIC17190.1 - 5.3e-08 33.2 0.1 9.6e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_14 PF13394.6 AIC17190.1 - 7.8e-06 26.0 0.4 2.6e-05 24.3 0.2 1.8 2 0 0 2 2 2 1 4Fe-4S single cluster domain EndIII_4Fe-2S PF10576.9 AIC17190.1 - 0.042 14.2 0.2 0.12 12.7 0.2 1.8 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Cyclase PF04199.13 AIC17191.1 - 4.7e-31 107.9 0.1 5.8e-31 107.5 0.1 1.1 1 0 0 1 1 1 1 Putative cyclase Mesd PF10185.9 AIC17191.1 - 0.21 11.5 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 Chaperone for wingless signalling and trafficking of LDL receptor AsnC_trans_reg PF01037.21 AIC17192.1 - 8.3e-13 48.1 0.1 9.1e-13 48.0 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIC17192.1 - 0.051 13.6 0.1 0.068 13.2 0.1 1.2 1 0 0 1 1 1 0 NapD protein Aminotran_5 PF00266.19 AIC17193.1 - 6.1e-66 222.9 0.0 7.1e-66 222.6 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Beta_elim_lyase PF01212.21 AIC17193.1 - 0.00032 20.1 0.1 0.00037 19.9 0.1 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase SHMT PF00464.19 AIC17193.1 - 0.13 10.8 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Serine hydroxymethyltransferase AAA_24 PF13479.6 AIC17194.1 - 0.0051 16.5 0.0 0.0058 16.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain TMEM125 PF15109.6 AIC17195.1 - 0.086 13.2 3.1 0.059 13.7 1.4 1.6 1 1 1 2 2 2 0 TMEM125 protein family OST3_OST6 PF04756.13 AIC17195.1 - 0.12 11.7 1.8 0.18 11.2 1.8 1.4 1 1 0 1 1 1 0 OST3 / OST6 family, transporter family Cpn60_TCP1 PF00118.24 AIC17197.1 - 3.9e-184 612.9 22.1 4.5e-184 612.7 22.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ustilago_mating PF05722.12 AIC17197.1 - 0.077 12.5 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 Ustilago B locus mating-type protein Rhomboid PF01694.22 AIC17198.1 - 2.2e-36 125.1 18.4 4.2e-36 124.2 18.4 1.4 1 0 0 1 1 1 1 Rhomboid family DUF1751 PF08551.10 AIC17198.1 - 0.1 13.2 0.4 0.1 13.2 0.4 2.6 2 1 1 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) zf-C2H2_4 PF13894.6 AIC17199.1 - 1.7e-05 25.2 1.8 2.3e-05 24.8 1.8 1.2 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 AIC17199.1 - 2e-05 24.8 2.8 2.5e-05 24.5 2.8 1.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 AIC17199.1 - 3e-05 23.7 4.4 4.2e-05 23.2 4.4 1.3 1 0 0 1 1 1 1 C2H2-type zinc-finger domain Actin_micro PF17003.5 AIC17199.1 - 0.00036 19.8 0.5 0.00041 19.7 0.5 1.0 1 0 0 1 1 1 1 Putative actin-like family zf-C2H2_2 PF12756.7 AIC17199.1 - 0.00048 20.4 0.2 0.0005 20.3 0.2 1.1 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) zf-BED PF02892.15 AIC17199.1 - 0.0017 18.3 0.3 0.0021 18.0 0.3 1.2 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_jaz PF12171.8 AIC17199.1 - 0.0042 17.3 2.9 0.0062 16.8 2.9 1.3 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding PyrI_C PF02748.15 AIC17199.1 - 0.0079 16.1 0.4 0.011 15.6 0.4 1.3 1 0 0 1 1 1 1 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-H2C2_2 PF13465.6 AIC17199.1 - 0.013 15.9 2.4 1.5 9.4 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger double domain DUF629 PF04780.12 AIC17199.1 - 0.014 14.0 0.1 0.015 13.9 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF629) HNH PF01844.23 AIC17199.1 - 0.016 15.4 0.2 0.02 15.1 0.2 1.2 1 0 0 1 1 1 0 HNH endonuclease zf-Di19 PF05605.12 AIC17199.1 - 0.02 15.2 0.1 0.025 14.9 0.1 1.1 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_3rep PF18868.1 AIC17199.1 - 0.026 15.2 0.4 0.029 15.0 0.4 1.1 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats DUF4187 PF13821.6 AIC17199.1 - 0.068 13.0 0.7 0.098 12.4 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) AsnC_trans_reg PF01037.21 AIC17200.1 - 1.4e-12 47.4 0.2 1.4e-12 47.4 0.2 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain GYD PF08734.11 AIC17200.1 - 0.013 15.4 0.1 0.013 15.4 0.1 1.2 1 0 0 1 1 1 0 GYD domain NapD PF03927.13 AIC17200.1 - 0.023 14.7 0.3 0.029 14.4 0.3 1.1 1 0 0 1 1 1 0 NapD protein MatB PF16449.5 AIC17200.1 - 0.082 12.7 0.0 0.094 12.5 0.0 1.1 1 0 0 1 1 1 0 Fimbrillin MatB HTH_20 PF12840.7 AIC17201.1 - 2e-05 24.5 0.4 3.4e-05 23.8 0.4 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MarR_2 PF12802.7 AIC17201.1 - 0.029 14.2 0.1 0.75 9.7 0.1 2.3 2 0 0 2 2 2 0 MarR family Ribosomal_L11_N PF03946.14 AIC17202.1 - 5e-21 74.3 0.7 1.2e-20 73.1 0.7 1.6 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ribosomal_L11 PF00298.19 AIC17202.1 - 8.5e-19 67.8 2.9 1.4e-18 67.1 2.9 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, RNA binding domain Qn_am_d_aIII PF09099.10 AIC17202.1 - 0.034 14.5 0.5 0.13 12.7 0.2 2.1 2 0 0 2 2 2 0 Quinohemoprotein amine dehydrogenase, alpha subunit domain III Peptidase_S8 PF00082.22 AIC17203.1 - 5.8e-33 114.4 0.7 1.1e-32 113.5 0.7 1.5 1 0 0 1 1 1 1 Subtilase family Big_3_3 PF13750.6 AIC17203.1 - 1.1e-09 38.1 0.2 0.0025 17.5 0.0 3.9 4 0 0 4 4 4 3 Bacterial Ig-like domain (group 3) Y_Y_Y PF07495.13 AIC17203.1 - 0.00061 19.7 0.1 0.33 10.9 0.0 3.2 3 0 0 3 3 3 1 Y_Y_Y domain DUF4165 PF13752.6 AIC17203.1 - 0.031 14.3 0.5 0.42 10.6 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4165) FixG_C PF11614.8 AIC17203.1 - 0.047 13.9 0.0 0.93 9.7 0.0 2.7 2 0 0 2 2 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase TcfC PF16967.5 AIC17203.1 - 0.057 12.9 0.0 2.8 7.5 0.0 2.6 2 0 0 2 2 2 0 E-set like domain EF-hand_5 PF13202.6 AIC17203.1 - 0.069 12.7 0.1 0.29 10.7 0.1 2.1 2 0 0 2 2 2 0 EF hand DUF916 PF06030.12 AIC17203.1 - 0.1 12.7 0.1 15 5.6 0.0 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF916) Thioredoxin PF00085.20 AIC17204.1 - 5.1e-29 100.3 0.0 5.7e-29 100.1 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AIC17204.1 - 5.7e-08 33.2 0.1 1.2e-06 28.9 0.1 2.0 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 AIC17204.1 - 1.5e-06 28.4 0.1 0.00017 21.9 0.0 2.2 1 1 1 2 2 2 1 Thioredoxin-like Redoxin PF08534.10 AIC17204.1 - 2.9e-06 27.0 0.1 5e-06 26.3 0.1 1.5 1 1 0 1 1 1 1 Redoxin AhpC-TSA PF00578.21 AIC17204.1 - 2.3e-05 24.3 0.2 9.2e-05 22.4 0.2 1.8 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 AIC17204.1 - 3.7e-05 23.8 0.1 6e-05 23.1 0.1 1.3 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_9 PF14595.6 AIC17204.1 - 0.00023 21.0 0.0 0.00025 20.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 AIC17204.1 - 0.00035 20.0 0.0 0.00039 19.9 0.0 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 AIC17204.1 - 0.0089 16.1 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin domain T4_deiodinase PF00837.17 AIC17204.1 - 0.0093 15.3 0.0 0.01 15.1 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase TraF PF13728.6 AIC17204.1 - 0.22 11.3 0.0 0.29 10.9 0.0 1.3 1 1 0 1 1 1 0 F plasmid transfer operon protein GTP_EFTU PF00009.27 AIC17205.1 - 9.5e-30 103.6 0.0 3.8e-29 101.6 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D4 PF14578.6 AIC17205.1 - 1.2e-25 89.2 0.4 3.9e-25 87.5 0.4 1.9 1 0 0 1 1 1 1 Elongation factor Tu domain 4 IF-2 PF11987.8 AIC17205.1 - 2.7e-20 72.4 1.0 2.7e-20 72.4 1.0 2.5 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 AIC17205.1 - 4.6e-09 36.5 1.5 2e-06 28.1 0.0 3.3 3 0 0 3 3 3 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 AIC17205.1 - 2.8e-07 30.6 0.0 1e-06 28.8 0.0 2.0 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 AIC17205.1 - 0.00021 21.5 0.0 0.00054 20.2 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 AIC17205.1 - 0.0015 18.4 3.0 1.5 8.7 0.1 4.0 3 1 1 4 4 4 2 RsgA GTPase Dynamin_N PF00350.23 AIC17205.1 - 0.0054 16.8 0.1 0.047 13.8 0.1 2.3 2 0 0 2 2 2 1 Dynamin family Ras PF00071.22 AIC17205.1 - 0.0063 16.1 0.0 0.079 12.6 0.0 2.4 1 1 0 1 1 1 1 Ras family ATP_bind_1 PF03029.17 AIC17205.1 - 0.0072 16.1 0.0 0.092 12.5 0.0 2.3 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein SRPRB PF09439.10 AIC17205.1 - 0.027 13.9 0.2 0.63 9.5 0.0 3.0 4 0 0 4 4 4 0 Signal recognition particle receptor beta subunit FeoB_N PF02421.18 AIC17205.1 - 0.19 11.2 1.1 2.3 7.7 0.1 3.1 3 1 0 3 3 3 0 Ferrous iron transport protein B DUF2971 PF11185.8 AIC17205.1 - 0.19 12.9 0.2 0.81 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2971) NDK PF00334.19 AIC17206.1 - 1.4e-47 161.1 0.0 1.6e-47 160.9 0.0 1.0 1 0 0 1 1 1 1 Nucleoside diphosphate kinase Ribosomal_L24e PF01246.20 AIC17207.1 - 1.4e-18 66.9 0.8 1.6e-18 66.7 0.8 1.1 1 0 0 1 1 1 1 Ribosomal protein L24e zf-FLZ PF04570.14 AIC17207.1 - 0.0013 18.2 1.0 0.0026 17.2 1.0 1.5 1 1 0 1 1 1 1 zinc-finger of the FCS-type, C2-C2 DUF2175 PF09943.9 AIC17207.1 - 0.036 14.4 0.1 0.039 14.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) Cas_CXXC_CXXC PF09706.10 AIC17207.1 - 0.047 13.9 0.3 0.058 13.6 0.3 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_CXXC_CXXC) DUF2116 PF09889.9 AIC17207.1 - 0.83 9.7 3.9 8.1 6.5 3.9 2.0 1 1 0 1 1 1 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Ribosomal_S28e PF01200.18 AIC17208.1 - 2.5e-29 101.1 6.4 2.8e-29 100.9 6.4 1.0 1 0 0 1 1 1 1 Ribosomal protein S28e Ribosomal_L7Ae PF01248.26 AIC17209.1 - 7.8e-27 92.9 0.2 9.5e-27 92.6 0.2 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family PELOTA_1 PF15608.6 AIC17209.1 - 0.0068 16.3 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 PELOTA RNA binding domain RNase_P_pop3 PF08228.11 AIC17209.1 - 0.15 12.1 0.0 0.16 12.0 0.0 1.1 1 0 0 1 1 1 0 RNase P subunit Pop3 PGM_PMM_I PF02878.16 AIC17210.1 - 5.6e-40 136.2 0.0 1.7e-39 134.7 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 AIC17210.1 - 3.5e-25 88.6 0.6 7.8e-25 87.5 0.1 1.9 2 0 0 2 2 2 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 AIC17210.1 - 3.6e-23 81.9 0.1 6.5e-23 81.1 0.1 1.4 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_IV PF00408.20 AIC17210.1 - 6.1e-10 39.1 0.0 1.8e-09 37.6 0.0 1.8 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain HEPN_Apea PF18739.1 AIC17211.1 - 7.1e-14 52.1 2.6 5.2e-12 46.1 0.0 3.2 2 1 1 3 3 3 1 Apea-like HEPN Rota_NSP4 PF01452.16 AIC17211.1 - 0.052 13.2 0.6 0.11 12.1 0.6 1.5 1 0 0 1 1 1 0 Rotavirus non structural protein SieB PF14163.6 AIC17211.1 - 0.053 13.0 0.1 0.11 12.0 0.1 1.5 1 0 0 1 1 1 0 Super-infection exclusion protein B DDE_Tnp_IS240 PF13610.6 AIC17212.1 - 1.3e-16 61.1 1.1 1.9e-16 60.6 0.4 1.7 2 0 0 2 2 1 1 DDE domain rve PF00665.26 AIC17212.1 - 3.5e-07 30.4 0.8 9.5e-07 29.0 0.8 1.7 1 1 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 AIC17212.1 - 1.6e-05 24.6 0.0 4.4e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 Integrase core domain Transposase_mut PF00872.18 AIC17212.1 - 0.00038 19.4 0.1 0.51 9.1 0.1 2.2 2 0 0 2 2 2 2 Transposase, Mutator family Zn_Tnp_IS1 PF03811.13 AIC17212.1 - 0.0036 17.0 1.6 0.0086 15.8 1.6 1.6 1 0 0 1 1 1 1 InsA N-terminal domain Lar_restr_allev PF14354.6 AIC17212.1 - 0.0052 17.1 0.4 0.011 16.1 0.4 1.5 1 0 0 1 1 1 1 Restriction alleviation protein Lar SWIM PF04434.17 AIC17212.1 - 0.0071 16.0 0.2 0.016 14.9 0.2 1.6 1 0 0 1 1 1 1 SWIM zinc finger Zn_Tnp_IS1595 PF12760.7 AIC17212.1 - 0.022 14.7 1.4 0.044 13.8 1.4 1.4 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Zn-ribbon_8 PF09723.10 AIC17212.1 - 0.023 14.8 3.2 1.4 9.1 0.1 3.0 2 1 0 2 2 2 0 Zinc ribbon domain HTH_28 PF13518.6 AIC17212.1 - 0.043 14.0 0.0 0.16 12.1 0.1 2.0 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_23 PF13384.6 AIC17212.1 - 0.089 12.6 0.2 2.7 7.9 0.1 2.5 2 0 0 2 2 2 0 Homeodomain-like domain Terminase_5 PF06056.12 AIC17212.1 - 0.094 12.6 0.1 0.43 10.5 0.1 2.1 1 1 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) DUF4974 PF16344.5 AIC17212.1 - 0.13 12.3 0.5 0.32 11.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4974) zinc_ribbon_4 PF13717.6 AIC17212.1 - 0.16 12.0 5.7 0.083 12.8 2.8 2.1 2 0 0 2 2 2 0 zinc-ribbon domain OrfB_Zn_ribbon PF07282.11 AIC17212.1 - 0.22 11.5 4.3 2.8 7.9 1.4 3.0 3 0 0 3 3 3 0 Putative transposase DNA-binding domain zf-C2H2 PF00096.26 AIC17212.1 - 2.2 8.9 6.4 0.26 11.8 1.3 2.2 2 0 0 2 2 1 0 Zinc finger, C2H2 type MazE_antitoxin PF04014.18 AIC17213.1 - 0.00055 19.8 1.0 0.0007 19.5 0.6 1.4 1 1 1 2 2 2 1 Antidote-toxin recognition MazE, bacterial antitoxin SOGA PF11365.8 AIC17215.1 - 0.04 15.0 5.1 0.042 15.0 5.1 1.1 1 0 0 1 1 1 0 Protein SOGA PKI PF02827.16 AIC17215.1 - 0.11 12.7 0.9 0.16 12.2 0.9 1.2 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor Cript PF10235.9 AIC17216.1 - 0.00068 20.2 0.5 0.00086 19.8 0.5 1.2 1 0 0 1 1 1 1 Microtubule-associated protein CRIPT DiS_P_DiS PF06750.13 AIC17216.1 - 0.0019 18.3 0.2 0.2 11.8 0.0 2.0 2 0 0 2 2 2 1 Bacterial Peptidase A24 N-terminal domain zf-ribbon_3 PF13248.6 AIC17216.1 - 0.0032 16.8 1.5 0.34 10.4 0.2 2.2 2 0 0 2 2 2 2 zinc-ribbon domain DZR PF12773.7 AIC17216.1 - 0.0033 17.4 1.1 0.0059 16.6 1.1 1.4 1 1 0 1 1 1 1 Double zinc ribbon zinc_ribbon_2 PF13240.6 AIC17216.1 - 0.0038 16.9 1.9 0.56 10.0 0.2 2.3 2 0 0 2 2 2 2 zinc-ribbon domain HypA PF01155.19 AIC17216.1 - 0.017 15.1 0.1 0.022 14.8 0.1 1.3 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF1272 PF06906.11 AIC17216.1 - 0.035 14.2 0.6 3.6 7.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) zf-TFIIB PF13453.6 AIC17216.1 - 0.039 13.3 0.5 1 8.7 0.1 2.2 2 0 0 2 2 2 0 Transcription factor zinc-finger Zn_ribbon_SprT PF17283.2 AIC17216.1 - 0.041 13.8 0.7 4.4 7.3 0.0 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain zinc-ribbons_6 PF07191.12 AIC17216.1 - 0.045 13.7 1.5 0.27 11.3 1.5 1.9 1 1 0 1 1 1 0 zinc-ribbons Nudix_N_2 PF14803.6 AIC17216.1 - 0.054 13.4 0.8 2.9 7.9 0.1 2.2 2 0 0 2 2 2 0 Nudix N-terminal Zn-ribbon_8 PF09723.10 AIC17216.1 - 0.061 13.5 1.4 0.25 11.5 1.5 1.8 1 1 0 1 1 1 0 Zinc ribbon domain DNA_ligase_ZBD PF03119.16 AIC17216.1 - 0.063 13.3 1.9 0.23 11.5 0.1 2.1 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain zf-LITAF-like PF10601.9 AIC17216.1 - 0.067 13.5 0.7 8.8 6.7 0.1 2.1 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain zf-ACC PF17848.1 AIC17216.1 - 0.076 13.1 1.8 1.6 8.9 0.1 2.3 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain PknG_rubred PF16919.5 AIC17216.1 - 0.1 12.8 0.1 0.12 12.5 0.1 1.2 1 0 0 1 1 1 0 Protein kinase G rubredoxin domain zinc_ribbon_4 PF13717.6 AIC17216.1 - 0.34 10.9 3.5 1.5 8.8 3.5 2.0 1 1 0 1 1 1 0 zinc-ribbon domain zf-ISL3 PF14690.6 AIC17216.1 - 0.99 10.1 5.4 5.1 7.8 1.2 2.4 1 1 1 2 2 2 0 zinc-finger of transposase IS204/IS1001/IS1096/IS1165 zf-C4_Topoisom PF01396.19 AIC17216.1 - 1.5 8.6 7.1 0.37 10.6 0.4 2.8 2 1 1 3 3 3 0 Topoisomerase DNA binding C4 zinc finger Ferritin PF00210.24 AIC17217.1 - 4.2e-21 75.4 3.6 5e-21 75.1 3.6 1.0 1 0 0 1 1 1 1 Ferritin-like domain Rubrerythrin PF02915.17 AIC17217.1 - 1.3e-05 25.6 4.3 3e-05 24.5 4.3 1.6 1 1 0 1 1 1 1 Rubrerythrin Get5_C PF18514.1 AIC17217.1 - 0.49 10.1 2.9 0.53 10.0 0.6 2.1 2 1 0 2 2 2 0 Get5 C-terminal domain PXT1 PF15214.6 AIC17218.1 - 0.13 12.7 0.0 0.26 11.6 0.0 1.5 2 0 0 2 2 2 0 Peroxisomal testis-specific protein 1 DNA_pol3_delta2 PF13177.6 AIC17219.1 - 0.0098 15.7 0.1 0.01 15.6 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase III, delta subunit SNO PF01174.19 AIC17220.1 - 1.3e-51 175.2 0.3 1.4e-51 175.0 0.3 1.0 1 0 0 1 1 1 1 SNO glutamine amidotransferase family GATase_3 PF07685.14 AIC17220.1 - 4e-13 49.4 0.0 9e-13 48.3 0.0 1.5 1 1 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain GATase PF00117.28 AIC17220.1 - 5.6e-09 36.0 0.0 1.3e-08 34.8 0.0 1.5 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 AIC17220.1 - 9.1e-06 25.6 0.1 0.00033 20.5 0.1 2.3 1 1 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 AIC17220.1 - 0.0022 17.8 0.0 0.0037 17.1 0.0 1.4 1 0 0 1 1 1 1 DJ-1/PfpI family Peptidase_S51 PF03575.17 AIC17220.1 - 0.0095 15.6 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 1 Peptidase family S51 SOR_SNZ PF01680.17 AIC17221.1 - 7.3e-98 326.4 5.8 1.1e-97 325.8 5.8 1.3 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 AIC17221.1 - 5.9e-08 32.3 6.7 7.9e-07 28.6 0.2 2.9 2 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG His_biosynth PF00977.21 AIC17221.1 - 3e-06 26.9 1.8 0.011 15.2 0.1 3.2 2 1 0 2 2 2 2 Histidine biosynthesis protein Dus PF01207.17 AIC17221.1 - 9.4e-06 24.9 0.8 0.082 12.0 0.2 2.3 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) NMO PF03060.15 AIC17221.1 - 0.00034 20.1 6.7 0.14 11.5 1.9 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase IGPS PF00218.21 AIC17221.1 - 0.00074 18.8 0.0 0.066 12.4 0.0 2.4 2 0 0 2 2 2 1 Indole-3-glycerol phosphate synthase NanE PF04131.14 AIC17221.1 - 0.01 15.0 3.6 0.23 10.6 0.0 2.8 2 1 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Peptidase_S66C PF17676.1 AIC17221.1 - 0.03 14.9 0.0 0.067 13.7 0.0 1.6 1 0 0 1 1 1 0 LD-carboxypeptidase C-terminal domain TetR_C_27 PF17935.1 AIC17221.1 - 0.055 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain PA PF02225.22 AIC17221.1 - 0.069 13.2 2.0 0.082 12.9 0.6 1.9 2 0 0 2 2 2 0 PA domain Aconitase PF00330.20 AIC17223.1 - 5.5e-146 487.2 0.0 7.3e-146 486.8 0.0 1.2 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 AIC17223.1 - 2.2e-36 125.1 0.0 4.1e-36 124.2 0.0 1.5 1 0 0 1 1 1 1 Aconitase C-terminal domain POR_N PF01855.19 AIC17226.1 - 2.2e-65 220.6 0.1 3.2e-65 220.1 0.1 1.2 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg POR PF01558.18 AIC17226.1 - 1.1e-36 126.6 0.4 2.4e-36 125.5 0.2 1.7 2 0 0 2 2 2 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PFOR_II PF17147.4 AIC17226.1 - 3e-12 46.7 0.1 7.5e-12 45.5 0.1 1.7 1 0 0 1 1 1 1 Pyruvate:ferredoxin oxidoreductase core domain II Transketolase_C PF02780.20 AIC17226.1 - 1.6e-07 31.2 0.0 3.9e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 Transketolase, C-terminal domain TPP_enzyme_N PF02776.18 AIC17226.1 - 0.0026 17.4 0.1 0.0055 16.3 0.1 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain PDZ_6 PF17820.1 AIC17226.1 - 0.093 12.6 0.0 0.22 11.4 0.0 1.7 1 0 0 1 1 1 0 PDZ domain DHNA PF04038.12 AIC17226.1 - 0.14 12.6 0.0 1.9 9.0 0.0 2.5 2 0 0 2 2 2 0 Dihydroneopterin aldolase TPP_enzyme_C PF02775.21 AIC17227.1 - 3.9e-30 104.7 0.1 6.7e-30 103.9 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain PFO_beta_C PF12367.8 AIC17227.1 - 7.9e-18 64.4 1.4 6.1e-16 58.3 0.9 2.8 2 1 0 2 2 2 1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal ChaB PF06150.12 AIC17228.1 - 3.1e-17 62.9 3.2 4.3e-17 62.4 3.2 1.2 1 0 0 1 1 1 1 ChaB DUF4145 PF13643.6 AIC17229.1 - 5.5e-10 39.2 0.1 6.6e-09 35.8 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4145) HEPN PF05168.14 AIC17229.1 - 0.0052 16.9 0.2 0.02 15.0 0.0 1.8 1 1 1 2 2 2 1 HEPN domain DUF86 PF01934.17 AIC17229.1 - 0.017 15.0 0.1 0.038 13.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF86 DUF1803 PF08820.10 AIC17229.1 - 0.42 10.7 6.2 0.4 10.7 0.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1803) DUF2207 PF09972.9 AIC17231.1 - 0.0023 16.8 1.2 0.0024 16.7 1.2 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) 2TM PF13239.6 AIC17231.1 - 0.016 15.5 1.8 0.019 15.2 1.8 1.1 1 0 0 1 1 1 0 2TM domain AsnC_trans_reg PF01037.21 AIC17232.1 - 3.1e-14 52.7 0.1 3.3e-14 52.6 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain ACT_5 PF13710.6 AIC17232.1 - 0.014 15.2 0.0 3.3 7.6 0.0 2.2 2 0 0 2 2 2 0 ACT domain ACT_4 PF13291.6 AIC17232.1 - 0.016 15.8 0.2 1.2 9.8 0.0 2.1 2 0 0 2 2 2 0 ACT domain NusG PF02357.19 AIC17232.1 - 0.048 14.2 0.2 9.7 6.8 0.2 2.1 1 1 1 2 2 2 0 Transcription termination factor nusG ADK_lid PF05191.14 AIC17235.1 - 0.0088 16.0 0.3 0.078 13.0 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase, active site lid Prim_Zn_Ribbon PF08273.12 AIC17235.1 - 0.052 13.8 0.6 0.066 13.5 0.6 1.2 1 0 0 1 1 1 0 Zinc-binding domain of primase-helicase DUF4428 PF14471.6 AIC17235.1 - 0.29 11.1 2.3 2 8.4 2.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4428) Copper-bind PF00127.20 AIC17236.1 - 0.00072 19.9 0.0 0.0011 19.4 0.0 1.2 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC17236.1 - 0.0019 18.3 0.0 0.0025 17.9 0.0 1.3 1 0 0 1 1 1 1 Cupredoxin-like domain AsnC_trans_reg PF01037.21 AIC17237.1 - 5.1e-11 42.4 0.1 5.3e-11 42.3 0.1 1.0 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain NapD PF03927.13 AIC17237.1 - 0.0075 16.3 0.2 0.0091 16.0 0.2 1.1 1 0 0 1 1 1 1 NapD protein ACT_4 PF13291.6 AIC17237.1 - 0.015 15.9 0.1 0.02 15.4 0.1 1.2 1 0 0 1 1 1 0 ACT domain ABC_tran PF00005.27 AIC17239.1 - 1.3e-21 77.6 0.0 2.4e-21 76.7 0.0 1.5 2 0 0 2 2 1 1 ABC transporter SMC_N PF02463.19 AIC17239.1 - 6.8e-11 42.0 0.5 1.6e-09 37.5 0.5 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 AIC17239.1 - 7.9e-10 39.0 0.1 0.0013 18.6 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 AIC17239.1 - 2.7e-05 23.8 0.1 6.3e-05 22.6 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 AIC17239.1 - 0.00015 21.7 0.1 0.00036 20.5 0.1 1.8 1 1 0 1 1 1 1 RsgA GTPase AAA_23 PF13476.6 AIC17239.1 - 0.00018 22.1 0.1 0.00037 21.1 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_13 PF13166.6 AIC17239.1 - 0.00069 18.4 0.0 0.21 10.2 0.0 2.1 2 0 0 2 2 2 2 AAA domain AAA_15 PF13175.6 AIC17239.1 - 0.0014 18.5 0.0 0.021 14.5 0.1 2.2 1 1 1 2 2 2 1 AAA ATPase domain AAA_27 PF13514.6 AIC17239.1 - 0.0018 17.9 0.1 0.0047 16.6 0.0 1.7 2 0 0 2 2 1 1 AAA domain AAA_25 PF13481.6 AIC17239.1 - 0.0029 17.2 0.0 0.064 12.8 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 AIC17239.1 - 0.0066 16.6 0.0 0.011 15.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 AIC17239.1 - 0.0077 16.6 0.0 0.034 14.5 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 AIC17239.1 - 0.017 15.6 0.2 0.18 12.4 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 AIC17239.1 - 0.02 15.1 0.1 0.17 12.2 0.1 2.4 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 AIC17239.1 - 0.024 15.1 0.1 0.12 12.8 0.1 2.2 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Dynamin_N PF00350.23 AIC17239.1 - 0.028 14.5 0.0 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 Dynamin family MMR_HSR1 PF01926.23 AIC17239.1 - 0.03 14.4 0.2 0.087 12.9 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_28 PF13521.6 AIC17239.1 - 0.044 14.0 0.1 0.2 11.9 0.0 2.0 2 1 0 3 3 2 0 AAA domain MutS_V PF00488.21 AIC17239.1 - 0.047 13.7 0.4 1.4 8.9 0.0 2.1 2 0 0 2 2 2 0 MutS domain V IstB_IS21 PF01695.17 AIC17239.1 - 0.054 13.2 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_ATPase PF09818.9 AIC17239.1 - 0.073 11.9 0.1 0.12 11.1 0.1 1.3 1 0 0 1 1 1 0 Predicted ATPase of the ABC class RNA_helicase PF00910.22 AIC17239.1 - 0.08 13.3 0.0 0.61 10.5 0.0 2.1 2 0 0 2 2 2 0 RNA helicase T2SSE PF00437.20 AIC17239.1 - 0.081 12.0 0.0 0.13 11.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein NACHT PF05729.12 AIC17239.1 - 0.1 12.5 0.0 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 AIC17239.1 - 0.12 11.6 0.0 0.23 10.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 AIC17239.1 - 0.12 12.3 0.1 0.3 11.0 0.0 1.7 2 1 0 2 2 1 0 ATPase domain predominantly from Archaea ATP_bind_1 PF03029.17 AIC17239.1 - 0.14 11.9 0.2 0.78 9.5 0.0 2.3 3 1 0 3 3 3 0 Conserved hypothetical ATP binding protein AIG1 PF04548.16 AIC17239.1 - 0.18 11.1 0.2 1.1 8.5 0.0 2.0 2 0 0 2 2 2 0 AIG1 family AAA_24 PF13479.6 AIC17239.1 - 0.18 11.5 0.2 0.43 10.3 0.1 1.7 2 0 0 2 2 2 0 AAA domain Chlor_dismutase PF06778.12 AIC17240.1 - 1.3e-60 204.4 0.7 1.5e-60 204.1 0.7 1.1 1 0 0 1 1 1 1 Chlorite dismutase DUF1802 PF08819.11 AIC17241.1 - 3.5e-58 196.3 0.1 3.9e-58 196.1 0.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1802) Aldo_ket_red PF00248.21 AIC17242.1 - 1.1e-57 195.5 0.1 1.3e-57 195.2 0.1 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AsnC_trans_reg2 PF17805.1 AIC17243.1 - 1.2e-54 182.3 0.0 6.9e-29 99.8 0.0 2.7 3 0 0 3 3 3 2 AsnC-like ligand binding domain HTH_AsnC-type PF13404.6 AIC17243.1 - 7.4e-10 38.5 0.0 0.00045 20.0 0.0 2.6 2 0 0 2 2 2 2 AsnC-type helix-turn-helix domain AsnC_trans_reg PF01037.21 AIC17243.1 - 9e-05 22.4 0.0 0.44 10.5 0.0 3.0 2 1 0 2 2 2 2 Lrp/AsnC ligand binding domain DUF2250 PF10007.9 AIC17243.1 - 0.021 14.9 0.0 1.9 8.6 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2250) Sigma70_r4 PF04545.16 AIC17243.1 - 0.022 14.3 0.0 0.12 11.9 0.0 2.2 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_24 PF13412.6 AIC17243.1 - 0.025 14.1 0.1 7.1 6.3 0.1 2.8 2 1 0 2 2 2 0 Winged helix-turn-helix DNA-binding NapD PF03927.13 AIC17243.1 - 0.11 12.5 0.0 0.59 10.2 0.0 2.1 2 0 0 2 2 2 0 NapD protein zf_UBZ PF18439.1 AIC17244.1 - 0.0081 15.7 1.7 0.0093 15.5 0.3 1.8 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger HTH_45 PF14947.6 AIC17245.1 - 2.8e-12 46.5 0.0 3.2e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC17245.1 - 9.7e-05 22.2 0.0 0.00013 21.7 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4364) PadR PF03551.14 AIC17245.1 - 0.00082 19.3 0.5 0.0011 18.9 0.5 1.2 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family DUF1495 PF07381.11 AIC17245.1 - 0.0022 17.8 0.1 0.0026 17.5 0.1 1.3 1 1 0 1 1 1 1 Winged helix DNA-binding domain (DUF1495) HTH_34 PF13601.6 AIC17245.1 - 0.006 16.7 0.0 0.0096 16.1 0.0 1.3 1 0 0 1 1 1 1 Winged helix DNA-binding domain Mrr_N PF14338.6 AIC17245.1 - 0.047 13.8 0.0 0.088 12.9 0.0 1.5 1 1 0 1 1 1 0 Mrr N-terminal domain HTH_27 PF13463.6 AIC17245.1 - 0.053 14.0 0.0 0.067 13.7 0.0 1.2 1 0 0 1 1 1 0 Winged helix DNA-binding domain MarR PF01047.22 AIC17245.1 - 0.077 12.9 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 MarR family DUF505 PF04458.12 AIC17245.1 - 0.11 10.9 0.0 0.12 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) UPF0061 PF02696.14 AIC17246.1 - 0.041 12.6 0.4 0.051 12.3 0.4 1.1 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family CxxCxxCC PF03692.15 AIC17247.1 - 8.3e-05 23.2 0.0 0.00013 22.5 0.0 1.5 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain Baculo_IE-1 PF05290.11 AIC17247.1 - 0.05 13.6 0.3 0.075 13.0 0.3 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) MJ1316 PF04457.12 AIC17248.1 - 0.00058 20.5 0.0 0.00072 20.2 0.0 1.1 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Aconitase_C PF00694.19 AIC17249.1 - 1.3e-21 77.3 0.0 2.3e-19 70.0 0.0 2.2 1 1 1 2 2 2 2 Aconitase C-terminal domain Aconitase_2_N PF06434.13 AIC17249.1 - 0.0039 16.8 0.1 0.017 14.8 0.1 1.9 1 1 0 1 1 1 1 Aconitate hydratase 2 N-terminus Aconitase PF00330.20 AIC17250.1 - 1.4e-92 311.1 6.9 2.4e-90 303.8 6.9 2.0 1 1 0 1 1 1 1 Aconitase family (aconitate hydratase) DUF521 PF04412.13 AIC17250.1 - 0.015 14.0 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF521) F420_ligase PF01996.16 AIC17251.1 - 1.8e-47 161.8 0.0 2.1e-47 161.5 0.0 1.0 1 0 0 1 1 1 1 F420-0:Gamma-glutamyl ligase TMF_DNA_bd PF12329.8 AIC17252.1 - 0.008 16.2 0.4 0.02 14.9 0.4 1.7 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding Peptidase_M50 PF02163.22 AIC17252.1 - 0.052 12.8 0.1 0.092 12.0 0.1 1.5 1 1 1 2 2 2 0 Peptidase family M50 DUF4250 PF14056.6 AIC17252.1 - 0.2 11.6 0.4 0.96 9.4 0.1 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4250) HTH_45 PF14947.6 AIC17255.1 - 6.4e-21 74.1 1.4 8.3e-21 73.8 1.4 1.1 1 0 0 1 1 1 1 Winged helix-turn-helix DUF4364 PF14277.6 AIC17255.1 - 8.6e-05 22.3 0.3 0.00014 21.7 0.2 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4364) AdoMet_dc PF02675.15 AIC17256.1 - 0.053 13.8 0.0 0.15 12.4 0.0 1.7 1 1 0 1 1 1 0 S-adenosylmethionine decarboxylase Band_7 PF01145.25 AIC17258.1 - 3.2e-32 112.0 0.6 3.2e-32 112.0 0.6 1.7 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 AIC17258.1 - 4.5e-05 23.3 0.1 0.00013 21.8 0.0 1.8 2 0 0 2 2 2 1 SPFH domain-Band 7 family NfeD PF01957.18 AIC17259.1 - 3.9e-11 43.2 0.8 1.1e-10 41.7 0.1 2.2 2 0 0 2 2 2 1 NfeD-like C-terminal, partner-binding CLP_protease PF00574.23 AIC17259.1 - 3e-06 27.2 0.3 1e-05 25.5 0.1 1.9 2 0 0 2 2 2 1 Clp protease FYVE_2 PF02318.16 AIC17260.1 - 0.74 10.0 10.1 0.54 10.5 8.3 1.8 2 0 0 2 2 2 0 FYVE-type zinc finger His_Phos_1 PF00300.22 AIC17261.1 - 7.1e-11 42.2 0.1 2.9e-10 40.2 0.1 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) CAP PF00188.26 AIC17262.1 - 2.6e-19 70.3 1.4 4.6e-19 69.5 1.4 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family Peripla_BP_2 PF01497.18 AIC17262.1 - 0.032 13.8 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein LEM PF03020.15 AIC17263.1 - 0.4 10.3 2.6 12 5.5 0.0 2.9 2 1 0 2 2 2 0 LEM domain NitrOD2 PF18550.1 AIC17264.1 - 2e-52 175.7 0.6 2.2e-52 175.6 0.6 1.0 1 0 0 1 1 1 1 Nitrososphaera output domain 2 DUF1376 PF07120.11 AIC17265.1 - 0.016 15.5 0.0 0.021 15.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1376) DnaJ_CXXCXGXG PF00684.19 AIC17266.1 - 0.063 13.6 17.0 0.53 10.7 9.2 2.6 1 1 1 2 2 2 0 DnaJ central domain zf-ribbon_3 PF13248.6 AIC17266.1 - 1.5 8.3 19.1 0.61 9.6 0.5 3.9 1 1 3 4 4 4 0 zinc-ribbon domain Big_7 PF17957.1 AIC17267.1 - 4.3e-12 46.6 8.7 1.5e-05 25.7 0.3 3.9 2 2 2 4 4 4 2 Bacterial Ig domain Copper-bind PF00127.20 AIC17267.1 - 3.8e-09 36.9 0.0 8.1e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Copper binding proteins, plastocyanin/azurin family Cupredoxin_1 PF13473.6 AIC17267.1 - 1.2e-07 31.7 0.0 5.3e-07 29.7 0.0 2.1 2 0 0 2 2 2 1 Cupredoxin-like domain Big_3_2 PF12245.8 AIC17267.1 - 0.0028 17.9 0.4 0.4 10.9 0.3 3.0 2 1 0 2 2 2 1 Bacterial Ig-like domain Gmad2 PF10648.9 AIC17267.1 - 0.012 15.8 0.1 0.038 14.2 0.1 2.0 1 0 0 1 1 1 0 Immunoglobulin-like domain of bacterial spore germination HYR PF02494.16 AIC17267.1 - 0.024 15.0 0.4 17 5.9 0.0 3.5 3 0 0 3 3 3 0 HYR domain Big_3_3 PF13750.6 AIC17267.1 - 0.031 13.9 0.0 0.28 10.8 0.0 2.2 2 0 0 2 2 2 0 Bacterial Ig-like domain (group 3) CelD_N PF02927.14 AIC17267.1 - 0.033 15.1 0.1 0.12 13.3 0.1 2.0 2 0 0 2 2 2 0 Cellulase N-terminal ig-like domain SdrD_B PF17210.3 AIC17267.1 - 0.04 14.1 0.4 0.19 12.0 0.1 2.3 3 0 0 3 3 3 0 SdrD B-like domain PKD PF00801.20 AIC17267.1 - 0.12 12.3 1.3 5.1 7.0 0.0 3.7 4 1 0 4 4 4 0 PKD domain Y_Y_Y PF07495.13 AIC17267.1 - 0.12 12.3 0.1 0.99 9.4 0.0 2.3 2 0 0 2 2 2 0 Y_Y_Y domain TIG_2 PF18020.1 AIC17268.1 - 0.023 15.3 0.5 0.33 11.6 0.2 2.5 2 0 0 2 2 2 0 TIG domain found in plexin DivIC PF04977.15 AIC17268.1 - 1.1 9.0 4.3 3 7.7 4.3 1.6 1 0 0 1 1 1 0 Septum formation initiator SH3-WW_linker PF16618.5 AIC17268.1 - 1.7 9.1 7.9 7 7.1 5.5 2.3 2 1 0 2 2 2 0 Linker region between SH3 and WW domains on ARHGAP12 HNH_3 PF13392.6 AIC17269.1 - 0.00095 18.9 0.2 0.0018 18.0 0.2 1.4 1 0 0 1 1 1 1 HNH endonuclease HNH PF01844.23 AIC17269.1 - 0.0014 18.7 0.2 0.0026 17.9 0.2 1.5 1 1 0 1 1 1 1 HNH endonuclease DZR PF12773.7 AIC17269.1 - 0.038 14.0 2.1 0.069 13.2 2.1 1.4 1 1 0 1 1 1 0 Double zinc ribbon Terminase_GpA PF05876.12 AIC17269.1 - 0.04 12.5 0.1 0.045 12.3 0.1 1.0 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) HAUS5 PF14817.6 AIC17269.1 - 0.095 11.4 0.0 0.11 11.2 0.0 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 NinF PF05810.12 AIC17269.1 - 0.1 12.5 0.5 4.9 7.1 0.1 2.1 2 0 0 2 2 2 0 NinF protein Zn-ribbon_8 PF09723.10 AIC17269.1 - 0.16 12.1 2.6 1.4 9.1 2.6 2.1 1 1 0 1 1 1 0 Zinc ribbon domain Nudix_N_2 PF14803.6 AIC17269.1 - 0.34 10.9 3.4 15 5.6 0.8 2.3 2 0 0 2 2 2 0 Nudix N-terminal LPAM_1 PF08139.12 AIC17270.1 - 0.2 12.2 6.0 0.5 11.0 6.0 1.7 1 0 0 1 1 1 0 Prokaryotic membrane lipoprotein lipid attachment site AsnC_trans_reg PF01037.21 AIC17273.1 - 5.6e-13 48.7 0.1 8.8e-13 48.0 0.1 1.3 1 0 0 1 1 1 1 Lrp/AsnC ligand binding domain HTH_24 PF13412.6 AIC17273.1 - 2.2e-09 36.7 0.5 3.4e-09 36.1 0.5 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_AsnC-type PF13404.6 AIC17273.1 - 7.3e-09 35.3 0.2 1.3e-08 34.5 0.2 1.4 1 0 0 1 1 1 1 AsnC-type helix-turn-helix domain HTH_20 PF12840.7 AIC17273.1 - 0.0016 18.4 0.0 0.006 16.6 0.0 1.8 2 0 0 2 2 2 1 Helix-turn-helix domain B-block_TFIIIC PF04182.12 AIC17273.1 - 0.0062 16.7 0.1 0.0084 16.3 0.1 1.3 1 0 0 1 1 1 1 B-block binding subunit of TFIIIC HTH_11 PF08279.12 AIC17273.1 - 0.01 15.8 0.3 0.023 14.6 0.3 1.6 1 0 0 1 1 1 0 HTH domain MarR PF01047.22 AIC17273.1 - 0.021 14.7 0.2 0.046 13.7 0.2 1.5 1 0 0 1 1 1 0 MarR family MarR_2 PF12802.7 AIC17273.1 - 0.031 14.2 0.0 0.053 13.4 0.0 1.3 1 0 0 1 1 1 0 MarR family TrmB PF01978.19 AIC17273.1 - 0.031 14.2 0.1 0.06 13.2 0.1 1.5 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Ribosomal_S25 PF03297.15 AIC17273.1 - 0.059 13.6 0.5 0.18 12.0 0.2 1.8 2 0 0 2 2 2 0 S25 ribosomal protein Rrf2 PF02082.20 AIC17273.1 - 0.069 13.5 0.1 0.14 12.5 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator HxlR PF01638.17 AIC17274.1 - 5.2e-07 29.4 0.1 6.1e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 HxlR-like helix-turn-helix HTH_45 PF14947.6 AIC17274.1 - 9.4e-05 22.3 0.0 0.00015 21.7 0.0 1.4 1 1 0 1 1 1 1 Winged helix-turn-helix PadR PF03551.14 AIC17274.1 - 0.0024 17.8 0.2 0.0037 17.2 0.2 1.4 1 0 0 1 1 1 1 Transcriptional regulator PadR-like family Replic_Relax PF13814.6 AIC17274.1 - 0.0044 17.1 0.1 0.006 16.7 0.1 1.2 1 0 0 1 1 1 1 Replication-relaxation HTH_5 PF01022.20 AIC17274.1 - 0.021 14.7 0.0 2.9 7.8 0.0 2.6 3 0 0 3 3 3 0 Bacterial regulatory protein, arsR family Cep3 PF16846.5 AIC17274.1 - 0.035 12.6 0.0 0.038 12.5 0.0 1.0 1 0 0 1 1 1 0 Centromere DNA-binding protein complex CBF3 subunit B HTH_34 PF13601.6 AIC17274.1 - 0.04 14.1 0.1 0.068 13.4 0.1 1.3 1 0 0 1 1 1 0 Winged helix DNA-binding domain HTH_20 PF12840.7 AIC17274.1 - 0.045 13.8 0.0 0.1 12.7 0.0 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_27 PF13463.6 AIC17274.1 - 0.059 13.9 0.1 0.1 13.1 0.1 1.4 1 0 0 1 1 1 0 Winged helix DNA-binding domain MEKHLA PF08670.11 AIC17274.1 - 0.079 12.9 0.1 0.084 12.8 0.1 1.2 1 0 0 1 1 1 0 MEKHLA domain MarR_2 PF12802.7 AIC17274.1 - 0.1 12.5 0.1 0.33 10.9 0.1 1.8 2 0 0 2 2 2 0 MarR family Tudor-knot PF11717.8 AIC17274.1 - 0.14 12.0 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain zf-C2H2_6 PF13912.6 AIC17275.1 - 0.26 11.3 2.6 1.3 9.1 0.0 2.5 3 0 0 3 3 3 0 C2H2-type zinc finger SecE PF00584.20 AIC17276.1 - 0.016 15.1 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex Thioredoxin PF00085.20 AIC17277.1 - 7.6e-31 106.2 0.0 8.6e-31 106.0 0.0 1.0 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_2 PF13098.6 AIC17277.1 - 9.1e-09 35.7 0.1 2.1e-07 31.3 0.1 2.1 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_9 PF14595.6 AIC17277.1 - 1.9e-07 30.9 0.0 2.1e-07 30.8 0.0 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 AIC17277.1 - 4.1e-07 30.2 0.0 0.00044 20.5 0.0 2.4 1 1 1 2 2 2 2 Thioredoxin-like Thioredoxin_3 PF13192.6 AIC17277.1 - 1.7e-06 28.0 0.0 2.2e-06 27.6 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_7 PF13899.6 AIC17277.1 - 2.3e-05 24.5 0.0 3.1e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Thioredoxin-like OST3_OST6 PF04756.13 AIC17277.1 - 0.00012 21.5 0.0 0.00012 21.5 0.0 1.1 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 AIC17277.1 - 0.0021 18.0 0.1 0.012 15.5 0.1 1.8 1 1 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 AIC17277.1 - 0.0029 17.3 0.1 0.0069 16.1 0.1 1.5 1 1 0 1 1 1 1 Redoxin HyaE PF07449.11 AIC17277.1 - 0.006 16.5 0.0 0.0088 16.0 0.0 1.3 1 0 0 1 1 1 1 Hydrogenase-1 expression protein HyaE Thioredoxin_6 PF13848.6 AIC17277.1 - 0.039 13.9 0.0 0.05 13.5 0.0 1.2 1 0 0 1 1 1 0 Thioredoxin-like domain DUF836 PF05768.14 AIC17277.1 - 0.054 13.9 0.0 0.074 13.5 0.0 1.3 1 0 0 1 1 1 0 Glutaredoxin-like domain (DUF836) tRNA-synt_2c PF01411.19 AIC17279.1 - 3.1e-83 280.2 0.0 4.9e-83 279.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 AIC17279.1 - 5e-16 58.5 4.6 1.7e-15 56.8 1.4 2.8 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain DHHA1 PF02272.19 AIC17279.1 - 5.6e-08 33.3 4.6 1.6e-07 31.8 4.6 1.9 1 0 0 1 1 1 1 DHHA1 domain YolD PF08863.10 AIC17279.1 - 0.066 13.3 0.1 0.48 10.5 0.0 2.4 2 0 0 2 2 2 0 YolD-like protein tRNA-synt_1 PF00133.22 AIC17280.1 - 1.2e-63 215.3 0.3 1.8e-62 211.4 0.3 2.6 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 AIC17280.1 - 1.8e-23 82.9 0.3 1.4e-11 43.8 0.1 3.3 2 1 1 3 3 3 2 tRNA synthetases class I (M) Anticodon_1 PF08264.13 AIC17280.1 - 1.7e-21 76.7 0.1 4.1e-21 75.5 0.1 1.6 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1e PF01406.19 AIC17280.1 - 2.3e-13 50.2 0.1 3.2e-08 33.3 0.0 2.6 2 0 0 2 2 2 2 tRNA synthetases class I (C) catalytic domain tRNA-synt_1_2 PF13603.6 AIC17280.1 - 4.6e-12 45.8 0.2 1.3e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 STI1 PF17830.1 AIC17280.1 - 0.0096 15.8 0.2 0.029 14.3 0.2 1.8 1 0 0 1 1 1 1 STI1 domain Response_reg PF00072.24 AIC17281.1 - 1.2e-23 83.4 0.0 1.8e-23 82.8 0.0 1.3 1 0 0 1 1 1 1 Response regulator receiver domain HTH_24 PF13412.6 AIC17281.1 - 0.00022 20.7 0.0 0.00039 19.9 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding HTH_45 PF14947.6 AIC17281.1 - 0.00029 20.8 0.0 0.00055 19.9 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix HATPase_c PF02518.26 AIC17283.1 - 1e-25 90.4 0.1 5.3e-25 88.1 0.0 2.3 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HisKA PF00512.25 AIC17283.1 - 3.8e-13 49.2 0.1 1.2e-12 47.7 0.1 1.9 1 0 0 1 1 1 1 His Kinase A (phospho-acceptor) domain HATPase_c_2 PF13581.6 AIC17283.1 - 0.0024 17.8 0.0 0.0063 16.5 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain Blt1 PF12754.7 AIC17284.1 - 0.11 12.8 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 Blt1 N-terminal domain DUF3040 PF11239.8 AIC17284.1 - 0.21 11.9 3.6 0.29 11.4 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) QCR10 PF09796.9 AIC17284.1 - 0.95 9.6 2.4 1.6 8.8 0.7 2.1 1 1 2 3 3 3 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Pyr_redox_2 PF07992.14 AIC17285.1 - 0.039 13.2 0.0 0.055 12.7 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 AIC17285.1 - 0.1 11.7 0.0 0.13 11.3 0.0 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein Prefoldin PF02996.17 AIC17286.1 - 5.8e-18 64.9 3.4 1.2e-17 64.0 3.1 1.6 1 1 0 1 1 1 1 Prefoldin subunit Prefoldin_2 PF01920.20 AIC17286.1 - 0.0018 18.2 8.7 0.0022 17.9 2.2 2.6 1 1 1 2 2 2 1 Prefoldin subunit Methyltransf_14 PF08484.11 AIC17286.1 - 0.0098 15.7 1.7 0.026 14.3 0.1 1.9 2 0 0 2 2 2 1 C-methyltransferase C-terminal domain Zip PF02535.22 AIC17286.1 - 0.041 13.1 1.6 0.034 13.4 1.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF948 PF06103.11 AIC17286.1 - 0.052 13.8 2.5 2.5 8.4 0.2 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 AIC17286.1 - 0.069 13.6 1.2 0.069 13.6 1.2 1.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.8 AIC17286.1 - 0.14 12.2 2.6 0.26 11.4 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) YlqD PF11068.8 AIC17286.1 - 0.16 12.3 11.0 0.084 13.2 3.3 2.2 2 0 0 2 2 2 0 YlqD protein FAP206 PF12018.8 AIC17286.1 - 0.17 11.4 3.3 4.5 6.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function EMP24_GP25L PF01105.24 AIC17286.1 - 0.28 11.1 4.1 2.2 8.2 0.2 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF4140 PF13600.6 AIC17286.1 - 1.3 9.5 6.3 4 7.9 1.4 2.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF16 PF01519.16 AIC17286.1 - 3.4 8.2 6.6 3.5 8.2 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF16 ABC_tran_Xtn PF12848.7 AIC17286.1 - 3.5 7.7 11.8 1.2 9.2 5.7 2.2 2 0 0 2 2 2 0 ABC transporter SRP54 PF00448.22 AIC17287.1 - 6.5e-69 231.5 0.4 9.3e-69 231.0 0.4 1.2 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP54_N PF02881.19 AIC17287.1 - 1.6e-08 34.6 6.6 1.6e-08 34.6 6.6 2.4 3 0 0 3 3 2 1 SRP54-type protein, helical bundle domain AAA_30 PF13604.6 AIC17287.1 - 7.8e-06 25.7 0.6 1.6e-05 24.8 0.6 1.4 1 0 0 1 1 1 1 AAA domain APS_kinase PF01583.20 AIC17287.1 - 0.00045 20.1 0.1 0.0012 18.8 0.1 1.7 1 0 0 1 1 1 1 Adenylylsulphate kinase KdpD PF02702.17 AIC17287.1 - 0.0011 18.5 0.1 0.002 17.6 0.1 1.5 1 0 0 1 1 1 1 Osmosensitive K+ channel His kinase sensor domain AAA_11 PF13086.6 AIC17287.1 - 0.0019 18.0 11.0 0.045 13.5 7.9 2.5 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 AIC17287.1 - 0.0028 17.9 0.0 0.0076 16.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 AIC17287.1 - 0.007 16.0 0.1 0.016 14.8 0.1 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CbiA PF01656.23 AIC17287.1 - 0.0091 16.1 0.0 0.021 14.9 0.0 1.7 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain Thymidylate_kin PF02223.17 AIC17287.1 - 0.011 15.4 0.0 0.011 15.4 0.0 2.8 2 1 0 2 2 1 0 Thymidylate kinase MeaB PF03308.16 AIC17287.1 - 0.017 14.1 0.8 0.065 12.2 0.3 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 AIC17287.1 - 0.018 15.5 0.1 0.018 15.5 0.1 2.2 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 AIC17287.1 - 0.066 13.6 0.2 0.17 12.3 0.2 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) CDC27 PF09507.10 AIC17287.1 - 0.71 9.2 39.7 1.1 8.5 39.7 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 EOS1 PF12326.8 AIC17287.1 - 2.8 7.8 3.5 4.7 7.1 3.5 1.4 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 AIC17287.1 - 5.7 6.9 8.9 9.5 6.2 8.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 AIC17287.1 - 5.9 5.7 9.2 8.4 5.2 9.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) OTCace_N PF02729.21 AIC17288.1 - 5.6e-54 182.2 0.0 8.4e-54 181.6 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 AIC17288.1 - 2.3e-53 180.5 0.0 3.3e-53 180.0 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain SNARE_assoc PF09335.11 AIC17289.1 - 1.1e-20 74.2 6.1 1.1e-20 74.2 6.1 2.4 2 1 1 3 3 3 1 SNARE associated Golgi protein Phage_holin_3_6 PF07332.11 AIC17289.1 - 0.0015 18.6 5.7 0.0015 18.6 5.7 2.8 2 1 0 2 2 2 1 Putative Actinobacterial Holin-X, holin superfamily III FeoB_associated PF12669.7 AIC17289.1 - 0.044 14.2 0.6 0.044 14.2 0.6 2.4 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Gram_pos_anchor PF00746.21 AIC17289.1 - 0.051 13.5 0.4 0.051 13.5 0.4 4.4 4 0 0 4 4 4 0 LPXTG cell wall anchor motif FixQ PF05545.11 AIC17289.1 - 0.48 10.4 0.0 0.48 10.4 0.0 2.6 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Peptidase_U4 PF03419.13 AIC17289.1 - 1.9 7.7 5.5 0.19 11.0 1.0 1.6 2 0 0 2 2 2 0 Sporulation factor SpoIIGA RseC_MucC PF04246.12 AIC17289.1 - 2.2 8.2 10.5 0.82 9.6 0.6 2.8 2 2 1 3 3 3 0 Positive regulator of sigma(E), RseC/MucC DUF763 PF05559.11 AIC17290.1 - 3.3e-115 384.6 0.0 3.8e-115 384.4 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF763) Rieske PF00355.26 AIC17291.1 - 6.1e-18 64.6 0.0 7.3e-18 64.3 0.0 1.1 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 AIC17291.1 - 1.2e-06 28.4 0.0 1.5e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Rieske-like [2Fe-2S] domain Thiamine_BP PF01910.17 AIC17292.1 - 1.6e-23 82.4 1.5 1.8e-23 82.3 1.5 1.0 1 0 0 1 1 1 1 Thiamine-binding protein DOT1 PF08123.13 AIC17294.1 - 8.5e-09 35.2 0.1 2e-07 30.8 0.1 2.2 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_25 PF13649.6 AIC17294.1 - 1.9e-07 31.7 0.1 3.6e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 AIC17294.1 - 1.9e-05 25.2 0.0 3.2e-05 24.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 AIC17294.1 - 0.00011 22.0 0.1 0.00018 21.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 AIC17294.1 - 0.00055 19.4 0.1 0.00073 19.0 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_4 PF02390.17 AIC17294.1 - 0.00056 19.4 0.0 0.0012 18.4 0.0 1.5 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_12 PF08242.12 AIC17294.1 - 0.0028 18.4 0.0 0.0051 17.5 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 AIC17294.1 - 0.0039 17.0 0.0 0.0079 16.0 0.0 1.6 1 1 1 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) CMAS PF02353.20 AIC17294.1 - 0.0046 16.3 0.0 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase MTS PF05175.14 AIC17294.1 - 0.049 13.2 0.0 0.13 11.8 0.1 1.6 2 0 0 2 2 2 0 Methyltransferase small domain PEPCK_ATP PF01293.20 AIC17298.1 - 1.1e-221 736.5 0.0 1.2e-221 736.3 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase PSD1 PF07587.11 AIC17298.1 - 0.014 14.9 0.0 0.025 14.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) AAA_33 PF13671.6 AIC17298.1 - 0.19 11.9 0.0 0.37 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain CxxCxxCC PF03692.15 AIC17300.1 - 2.6e-08 34.4 0.2 8.7e-08 32.8 0.2 1.8 1 1 0 1 1 1 1 Putative zinc- or iron-chelating domain Sod_Fe_C PF02777.18 AIC17303.1 - 9.3e-39 131.7 0.8 1.9e-38 130.7 0.8 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 AIC17303.1 - 4.9e-29 100.6 1.6 4.9e-29 100.6 1.6 1.7 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DNA_gyraseB PF00204.25 AIC17303.1 - 0.12 11.8 0.1 0.2 11.1 0.1 1.4 1 0 0 1 1 1 0 DNA gyrase B SpaA PF17802.1 AIC17304.1 - 1.1e-06 28.9 0.6 3e-06 27.4 0.2 2.0 2 0 0 2 2 2 1 Prealbumin-like fold domain # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Nitrososphaera_viennensis_EN76-ASM69878v1/GCA_000698785.1_ASM69878v1_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Nitrososphaera_viennensis_EN76-ASM69878v1/GCA_000698785.1_ASM69878v1_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Nitrososphaera_viennensis_EN76-ASM69878v1/GCA_000698785.1_ASM69878v1_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Archaea/Thaumarchaeota/Nitrososphaera_viennensis_EN76-ASM69878v1/GCA_000698785.1_ASM69878v1_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Mon Mar 25 13:04:27 2019 # [ok]