# hmmscan :: search sequence(s) against a profile database # HMMER 3.0 (March 2010); http://hmmer.org/ # Copyright (C) 2010 Howard Hughes Medical Institute. # Freely distributed under the GNU General Public License (GPLv3). # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - # query sequence file: CAP-D3.fasta # target HMM database: /N/dc2/projects/marinovg/genomes/PFam/PFam27.0/Pfam-A.hmm # output directed to file: CAP-D3.PFam-27-A # per-seq hits tabular output: Spt16-hmmscan.tblout # number of worker threads: 16 # - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: gi|45356151|ref|NP_056076.1| [L=1498] Description: condensin-2 complex subunit D3 [Homo sapiens] Scores for complete sequence (score includes all domains): --- full sequence --- --- best 1 domain --- -#dom- E-value score bias E-value score bias exp N Model Description ------- ------ ----- ------- ------ ----- ---- -- -------- ----------- 1.4e-63 213.9 22.3 6.5e-57 192.2 2.3 7.1 7 Cnd1 non-SMC mitotic condensation complex subunit 1 4.5e-08 32.5 17.3 0.22 11.6 0.0 8.4 9 HEAT HEAT repeat 5.7e-08 32.9 2.0 0.077 13.2 0.1 5.0 5 HEAT_2 HEAT repeats 1.3e-05 23.7 19.0 0.00052 18.4 1.6 4.8 6 Adaptin_N Adaptin N terminal region 0.0002 21.2 0.9 0.01 15.8 0.1 3.3 3 Cohesin_HEAT HEAT repeat associated with sister chromatid co 0.0024 17.6 0.4 0.0079 15.9 0.2 1.9 2 DUF3013 Protein of unknown function (DUF3013) ------ inclusion threshold ------ 0.015 14.9 0.3 0.29 10.7 0.0 2.7 2 VHS VHS domain 0.21 12.1 3.4 57 4.3 0.0 5.3 6 HEAT_EZ HEAT-like repeat 0.34 10.8 4.3 5.1 7.0 0.0 4.5 6 DUF2435 Protein of unknown function (DUF2435) Domain annotation for each model (and alignments): >> Cnd1 non-SMC mitotic condensation complex subunit 1 # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -0.4 0.0 0.52 8.6e+02 57 111 .. 327 386 .. 323 415 .. 0.75 2 ? 0.9 0.0 0.21 3.4e+02 59 108 .. 440 488 .. 430 520 .. 0.71 3 ? 3.3 0.2 0.039 65 27 51 .. 543 567 .. 540 573 .. 0.86 4 ! 12.0 0.0 8.3e-05 0.14 31 93 .. 585 649 .. 580 660 .. 0.88 5 ! 8.4 0.0 0.001 1.7 2 34 .. 917 949 .. 916 951 .. 0.93 6 ! 192.2 2.3 3.9e-60 6.5e-57 2 177 .. 955 1152 .. 954 1153 .. 0.98 7 ? 4.1 0.1 0.022 37 81 139 .. 1175 1232 .. 1168 1294 .. 0.71 Alignments for each domain: == domain 1 score: -0.4 bits; conditional E-value: 0.52 Cnd1 57 mvKvkgqlflemlkllaDe.deeiralAelffsellkkk.....npnllynllpelisvLn 111 ++ +++q ++++ +l+De +e i + +++++++ k + + ++l++l+s+L gi|45356151|ref|NP_056076.1| 327 VINCRNQA-VQFISALVDElKESIFPVVRILLQHICAKVvdkseYRTFAAQSLVQLLSKLP 386 67788899.8888888887457799999999999988765444344444888888888875 PP == domain 2 score: 0.9 bits; conditional E-value: 0.21 Cnd1 59 Kvkgqlflemlkll.aDedeeiralAelffsellkkknpnllynllpelis 108 K k + +e++ D+ +++r+ A + f + l+ ++ ++ el++ gi|45356151|ref|NP_056076.1| 440 KHKFLV-QEIMFDRcLDKAPTVRSKALSSFAHCLEL-TVTSASESILELLI 488 555544.56555554899999999999999999986.66777777777776 PP == domain 3 score: 3.3 bits; conditional E-value: 0.039 Cnd1 27 leklyacLkdedalvRktallvlsh 51 + +l ++++de+ vRk al vl + gi|45356151|ref|NP_056076.1| 543 MAMLRRRIRDEKTNVRKSALQVLVS 567 5679999*************99965 PP == domain 4 score: 12.0 bits; conditional E-value: 8.3e-05 Cnd1 31 yacLkdedalvRktallvlshLiled..mvKvkgqlflemlkllaDedeeiralAelffsellkk 93 +++d+ +vRk+al l++L++ v++++ + ++ + D ++++++ A f+ +ll++ gi|45356151|ref|NP_056076.1| 585 QDQCRDPAVSVRKQALQSLTELLMAQprCVQIQKAWLRGVVPVVMDCESTVQEKALEFLDQLLLQ 649 567899****************98863379999***99999999****************99986 PP == domain 5 score: 8.4 bits; conditional E-value: 0.001 Cnd1 2 pliranavialgDLcvrypnlvdpyleklyacL 34 ++ira a+i+lg Lc +++ l ++++ l++ L gi|45356151|ref|NP_056076.1| 917 SVIRAHAIITLGKLCLQHEDLAKKSIPALVREL 949 58***************************9987 PP == domain 6 score: 192.2 bits; conditional E-value: 3.9e-60 Cnd1 2 pliranavialgDLcvrypnlvdpyleklyacLkdedalvRktallvlshLiledmvKvkgqlflemlkllaDedeeir 80 ++r+n++i+++DLc+ry+ +vd+y++++ cLkd+d+++Rk++l++l++L++e++vK+kg+lf++++ +l D++++i+ gi|45356151|ref|NP_056076.1| 955 VAVRNNVIIVMCDLCIRYTIMVDKYIPNISMCLKDSDPFIRKQTLILLTNLLQEEFVKWKGSLFFRFVSTLIDSHPDIA 1033 589**************************************************************************** PP Cnd1 81 alAelffsellkkknpnllynllpelisvLnnctehelv................eeldeerrkkiykfllefikkdkq 143 ++ e+++ +ll+k+np +++++++e+i+++nn+++he++ + ++err+kiykflle+++ d+q gi|45356151|ref|NP_056076.1| 1034 SFGEFCLAHLLLKRNPVMFFQHFIECIFHFNNYEKHEKYnkfpqserekrlfslkGKSNKERRMKIYKFLLEHFT-DEQ 1111 *******************************************************669*****************.*** PP Cnd1 144 keslveklcsrllaanv.......eadakvlsdilvilsll 177 +++++ k+c ++la++ ++ ++lsd++ +ls++ gi|45356151|ref|NP_056076.1| 1112 RFNITSKICLSILACFAdgilpldLDASELLSDTFEVLSSK 1152 ***********************999999********9997 PP == domain 7 score: 4.1 bits; conditional E-value: 0.022 Cnd1 81 alAelffsellkkk....npnllynllpelisvLnnctehelv..........eeldeerrkkiykfllefik 139 alA+ +++e +kk ++++++ +++ +i++L + e++++ + e ++ gi|45356151|ref|NP_056076.1| 1175 ALANVVMQEAQKKLisqvQKRNFIENIIPIIISLKTVLEKNKIpalrelmhylR---------------EVMQ 1232 6889999999998888889999*************9999887755544433330...............2222 PP >> HEAT HEAT repeat # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 2.4 0.0 0.12 2e+02 14 30 .. 368 384 .. 352 385 .. 0.79 2 ? 4.7 0.0 0.022 36 7 28 .. 451 472 .. 445 474 .. 0.82 3 ! 11.6 0.0 0.00013 0.22 2 31 .] 543 572 .. 542 572 .. 0.91 4 ! 9.9 0.1 0.00049 0.81 4 27 .. 583 606 .. 581 608 .. 0.90 5 ? -3.5 0.0 9 1.5e+04 10 27 .. 629 646 .. 626 647 .. 0.83 6 ? -1.6 0.1 2.4 4e+03 15 29 .. 793 807 .. 791 809 .. 0.82 7 ? -3.3 0.0 8.6 1.4e+04 22 31 .] 858 867 .. 857 867 .. 0.85 8 ? 0.4 0.0 0.56 9.2e+02 16 29 .. 919 932 .. 917 934 .. 0.88 9 ! 7.5 0.0 0.0029 4.9 2 29 .. 980 1007 .. 980 1008 .. 0.91 Alignments for each domain: == domain 1 score: 2.4 bits; conditional E-value: 0.12 HHHHHHHHHHHHHHHHC CS HEAT 14 peVReaAaeaLgalaev 30 e R +Aa++L +l+++ gi|45356151|ref|NP_056076.1| 368 SEYRTFAAQSLVQLLSK 384 488***********876 PP == domain 2 score: 4.7 bits; conditional E-value: 0.022 HHHTSSSHHHHHHHHHHHHHHH CS HEAT 7 kllnDpspeVReaAaeaLgala 28 + D++p VR+ A+++++ + gi|45356151|ref|NP_056076.1| 451 DRCLDKAPTVRSKALSSFAHCL 472 5678************998766 PP == domain 3 score: 11.6 bits; conditional E-value: 0.00013 HHHHHHHHTSSSHHHHHHHHHHHHHHHHCC CS HEAT 2 lPlllkllnDpspeVReaAaeaLgalaevl 31 + l + + D+ +VR++A++ L +++++ gi|45356151|ref|NP_056076.1| 543 MAMLRRRIRDEKTNVRKSALQVLVSILKHC 572 667889999*******************98 PP == domain 4 score: 9.9 bits; conditional E-value: 0.00049 HHHHHHTSSSHHHHHHHHHHHHHH CS HEAT 4 lllkllnDpspeVReaAaeaLgal 27 +l+ + Dp+ +VR++A+++L++l gi|45356151|ref|NP_056076.1| 583 ILQDQCRDPAVSVRKQALQSLTEL 606 688899***************998 PP == domain 5 score: -3.5 bits; conditional E-value: 9 TSSSHHHHHHHHHHHHHH CS HEAT 10 nDpspeVReaAaeaLgal 27 D + V e A+e L +l gi|45356151|ref|NP_056076.1| 629 MDCESTVQEKALEFLDQL 646 588899*****9988776 PP == domain 6 score: -1.6 bits; conditional E-value: 2.4 HHHHHHHHHHHHHHH CS HEAT 15 eVReaAaeaLgalae 29 eV ++A+ aL +l++ gi|45356151|ref|NP_056076.1| 793 EVISSAVDALQRLCR 807 56678********97 PP == domain 7 score: -3.3 bits; conditional E-value: 8.6 HHHHHHHHCC CS HEAT 22 eaLgalaevl 31 ++Lg++a+ + gi|45356151|ref|NP_056076.1| 858 FTLGDIAQLC 867 79*****987 PP == domain 8 score: 0.4 bits; conditional E-value: 0.56 HHHHHHHHHHHHHH CS HEAT 16 VReaAaeaLgalae 29 +R+ A+ +Lg l+ gi|45356151|ref|NP_056076.1| 919 IRAHAIITLGKLCL 932 8***********95 PP == domain 9 score: 7.5 bits; conditional E-value: 0.0029 HHHHHHHHTSSSHHHHHHHHHHHHHHHH CS HEAT 2 lPlllkllnDpspeVReaAaeaLgalae 29 +P + +l+D++p +R++++ L++l++ gi|45356151|ref|NP_056076.1| 980 IPNISMCLKDSDPFIRKQTLILLTNLLQ 1007 688889*****************99986 PP >> HEAT_2 HEAT repeats # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 1.5 0.0 0.22 3.7e+02 34 75 .. 447 491 .. 414 499 .. 0.73 2 ! 13.2 0.1 4.7e-05 0.077 33 87 .. 543 603 .. 454 604 .. 0.81 3 ! 12.3 0.2 9.2e-05 0.15 35 87 .. 545 603 .. 543 690 .. 0.75 4 ? -4.0 0.0 9 1.5e+04 20 29 .. 798 807 .. 793 822 .. 0.49 5 ! 11.8 0.0 0.00014 0.22 1 58 [. 942 1005 .. 942 1013 .. 0.83 Alignments for each domain: == domain 1 score: 1.5 bits; conditional E-value: 0.22 HEAT_2 34 paLlelLkdedpevRraAaeaLg...klgdpealpaLlkllddde 75 +++++ + d+ p vR +A+ + + +l +a +++l+ll +++ gi|45356151|ref|NP_056076.1| 447 EIMFDRCLDKAPTVRSKALSSFAhclELTVTSASESILELLINSP 491 556677778888888888888884333456777788888777766 PP == domain 2 score: 13.2 bits; conditional E-value: 4.7e-05 HEAT_2 33 lpaLlelLkdedpevRraAaeaLgkl.......gdpealpaLlklldddedavvreaAaeaL 87 +++L++ ++de +vR++A+++L + g +e l L + +d+ +v r +A+++L gi|45356151|ref|NP_056076.1| 543 MAMLRRRIRDEKTNVRKSALQVLVSIlkhcdvsGMKEDLWILQDQCRDPAVSV-RKQALQSL 603 78999*******************99888888888999********9998887.66679988 PP == domain 3 score: 12.3 bits; conditional E-value: 9.2e-05 HEAT_2 35 aLlelLkdedpevRraAaeaLgkl.......gdpealpaLlklldddedavvreaAaeaL 87 +L++ ++de +vR++A+++L + g +e l L + +d+ +v r +A+++L gi|45356151|ref|NP_056076.1| 545 MLRRRIRDEKTNVRKSALQVLVSIlkhcdvsGMKEDLWILQDQCRDPAVSV-RKQALQSL 603 455555666666666666666555555555445555555555555555554.33445554 PP == domain 4 score: -4.0 bits; conditional E-value: 9 HEAT_2 20 aieaLgqlgs 29 a++aL +l gi|45356151|ref|NP_056076.1| 798 AVDALQRLCR 807 3333333322 PP == domain 5 score: 11.8 bits; conditional E-value: 0.00014 HEAT_2 1 leaLlaaLekdpdpevraaaieaLgqlgse......ealpaLlelLkdedpevRraAaeaLgkl 58 ++aL+ +Le +d vr ++i ++++l + + +p + +Lkd+dp +R++ ++ L +l gi|45356151|ref|NP_056076.1| 942 IPALVRELEVCEDVAVRNNVIIVMCDLCIRytimvdKYIPNISMCLKDSDPFIRKQTLILLTNL 1005 699*****88***************6554433333377******************99998876 PP >> Adaptin_N Adaptin N terminal region # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -0.6 0.1 0.18 3e+02 357 409 .. 331 386 .. 321 407 .. 0.52 2 ? -0.2 0.0 0.14 2.3e+02 125 166 .. 455 493 .. 446 499 .. 0.71 3 ! 13.0 0.4 1.4e-05 0.023 80 180 .. 542 652 .. 540 686 .. 0.79 4 ? 2.4 0.0 0.023 38 381 501 .. 702 830 .. 691 849 .. 0.77 5 ! 18.4 1.6 3.2e-07 0.00052 140 336 .. 764 1010 .. 742 1029 .. 0.79 6 ? -2.9 0.0 0.88 1.5e+03 327 359 .. 1206 1237 .. 1203 1239 .. 0.85 Alignments for each domain: == domain 1 score: -0.6 bits; conditional E-value: 0.18 XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX....XXXXXXXXXXXXXXXXXXXXX CS Adaptin_N 357 ksklvkaIgrlaekfaedaewvldvllellsl...sgeyvkdeivevirdiiqkvp 409 + ++v+ I+ l + +e++ v+ +ll++++ +++ ++ +++++ ++++k p gi|45356151|ref|NP_056076.1| 331 RNQAVQFISALVDELKESIFPVVRILLQHICAkvvDKSEYRTFAAQSLVQLLSKLP 386 44455555555555555555555555555554222223344444444444444433 PP == domain 2 score: -0.2 bits; conditional E-value: 0.14 -SSHHHHHHHHHHHHHCCCCHHHHHHCC.HHHHHHHT.T-SSH CS Adaptin_N 125 drspyVrkkAalailklykkdpdlvrkqlveeikell.sdkdp 166 d+ p Vr+kA+ +++++++++ ++ i ell ++++ gi|45356151|ref|NP_056076.1| 455 DKAPTVRSKALSSFAHCLELTVTSASE----SILELLiNSPTF 493 788999999999999999998877533....344444355555 PP == domain 3 score: 13.0 bits; conditional E-value: 1.4e-05 GHHHHHHHHCSS-HHHHHHHHHHHHHC-....-TTTHHHHHHHHHHHHT-SSHHHHHHHHHHHHHCCCCHHHHHHCC...H CS Adaptin_N 80 vtnslqkDlkspnqlirglALrvLssir....vpelaedladaikkllkdrspyVrkkAalailklykkdpdlvrkq..lv 154 v+ +l++ + + +++r +AL+vL si v+ + edl +++ +d+ Vrk+A+++++ l+ ++p v+ q ++ gi|45356151|ref|NP_056076.1| 542 VMAMLRRRIRDEKTNVRKSALQVLVSILkhcdVSGMKEDLW-ILQDQCRDPAVSVRKQALQSLTELLMAQPRCVQIQkaWL 621 55678888889999999999999999986666667777765.577777888889999999999999999999888877889 PP HHHHHHTT-SSHHHHHHHHHHHHHH.....H CS Adaptin_N 155 eeikellsdkdpgVvlaAvalleei.....k 180 ++ + d + V+ A+ l+++ + gi|45356151|ref|NP_056076.1| 622 RGVVPVVMDCESTVQEKALEFLDQLllqniR 652 9999999999999999999999998655443 PP == domain 4 score: 2.4 bits; conditional E-value: 0.023 XXXXXXX.XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXXXXXXXXXXXXXXXXX.....XXXXXX CS Adaptin_N 381 vllellslsgeyvkdeivevirdiiqkvpelhekivekLaellekiespe..araaaiWllGeygelven.te.sasdllr 457 ++ +++s +g+ +++ ++ + +i p l + + + e ++++++p+ + ++ ++G +++++++ t+ +++d ++ gi|45356151|ref|NP_056076.1| 702 FINNVISHTGTEHSAPAWMLLSKIAGSSPRLDYSRIIQSWEKISSQQNPNsnTLGHILCVIGHIAKHLPKsTRdKVTDAVK 782 56689999999999999*************9998888889999998888844588999999*******9987788888888 PP XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX..XXX.....XXXXXXXXX CS Adaptin_N 458 slaekfvlesekvklailtalvKlsltspdketqe.....eliqlvlsl 501 ++ f + s++v ++++ al++l++ s++ +e +++ vls gi|45356151|ref|NP_056076.1| 783 CKLNGF-QWSLEVISSAVDALQRLCRASAETPAEEqelltQVCGDVLST 830 777765.667779999999999999777643222244444555555555 PP == domain 5 score: 18.4 bits; conditional E-value: 3.2e-07 HCCCCHHHHHHCC.HHHHHHHTT-SS..HHHHHHHHHHHHHH.......HTT-HHHH.....HHHHHHHCS........ CS Adaptin_N 140 klykkdpdlvrkqlveeikellsdkd..pgVvlaAvalleei.......kkndrlll.....kllpklvrrLcnll... 201 ++ k p+ r+++++ +k +l+ + V+++Av +l+++ ++++ll ++l++ +rL+n++ gi|45356151|ref|NP_056076.1| 764 HIAKHLPKSTRDKVTDAVKCKLNGFQwsLEVISSAVDALQRLcrasaetPAEEQELLtqvcgDVLSTCEHRLSNIVlke 842 5666666666666777777777544433799***********9988877333333336889999999999999999*** PP ...--S-HHHHHHHHHHHC-XXXXXXXXX..XXXXXXXX--S-............................-SSHHHHH CS Adaptin_N 202 ...telnpwlqvkiiklltrlarqepeerskkellesllnllq............................ssnnaVll 249 +++++ l vk i +l + a+ p++ +k +++ +++ l+ s+ ++V+ gi|45356151|ref|NP_056076.1| 843 ngtGNMDEDLLVKYIFTLGDIAQLCPARVEK-RIFLLIQSVLAssadadhspssqgsseapasqpppqvrgSVMPSVIR 920 ***99999999********999999999975.788888888888889********************555555555554 PP HHHHHCT.....-XXXXXX.....---THHHHHH.SSSTTCHHHHHC--XXXXXXXXXXXXXXXX..XXXXXXXXXXXX CS Adaptin_N 250 etvkliv.....elapkne.liklavnaLvrlls.skdenlryvaLrnlnkilekepkavqhldl..kifllktdddvs 319 + +l + e l+k+ + aLvr l+ +d ++r ++ ++ ++ + + + ++++ ++ +lk d d gi|45356151|ref|NP_056076.1| 921 AH----AiitlgKLCLQHEdLAKKSIPALVRELEvCEDVAVRNNVIIVMCDLCIRY-TIMVDKYIpnISMCLK-DSDPF 993 43....2223455554444699***********9999*******************.5555555543666777.***** PP XXXXXXXXXXXXXXXXX CS Adaptin_N 320 irlkaldlllklvdesN 336 ir+++l ll++l++e+ gi|45356151|ref|NP_056076.1| 994 IRKQTLILLTNLLQEEF 1010 ************99875 PP == domain 6 score: -2.9 bits; conditional E-value: 0.88 XXXXXXXXXXXXXXXXXXXXXXXXXXXX.XXXX CS Adaptin_N 327 lllklvdesNvkeivkeLkkyvsevadeefksk 359 ++lk+v e+N ++eL+ y++ev ++++++ gi|45356151|ref|NP_056076.1| 1206 ISLKTVLEKNKIPALRELMHYLREV-MQDYRDE 1237 788999999999999*******999.7779886 PP >> Cohesin_HEAT HEAT repeat associated with sister chromatid cohesion # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ! 15.8 0.1 6.1e-06 0.01 19 42 .] 542 565 .. 538 565 .. 0.94 2 ? 1.9 0.0 0.13 2.2e+02 28 41 .. 589 602 .. 589 603 .. 0.87 3 ? -2.1 0.0 2.4 3.9e+03 25 42 .] 985 1002 .. 983 1002 .. 0.82 Alignments for each domain: == domain 1 score: 15.8 bits; conditional E-value: 6.1e-06 Cohesin_HEAT 19 vqeaiarrltDsspsVRdAalell 42 v+ ++ rr +D++++VR++al+ l gi|45356151|ref|NP_056076.1| 542 VMAMLRRRIRDEKTNVRKSALQVL 565 7899*****************976 PP == domain 2 score: 1.9 bits; conditional E-value: 0.13 Cohesin_HEAT 28 tDsspsVRdAalel 41 +D+++sVR+ al+ gi|45356151|ref|NP_056076.1| 589 RDPAVSVRKQALQS 602 6********99985 PP == domain 3 score: -2.1 bits; conditional E-value: 2.4 Cohesin_HEAT 25 rrltDsspsVRdAalell 42 +l Ds+p +R+ +l ll gi|45356151|ref|NP_056076.1| 985 MCLKDSDPFIRKQTLILL 1002 599*****9999888876 PP >> DUF3013 Protein of unknown function (DUF3013) # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -2.8 0.0 2.6 4.3e+03 57 80 .. 634 658 .. 628 670 .. 0.76 2 ! 15.9 0.2 4.8e-06 0.0079 101 150 .. 1220 1269 .. 1175 1275 .. 0.91 Alignments for each domain: == domain 1 score: -2.8 bits; conditional E-value: 2.6 XXXXXEEEEEEEEEEE-TTT.---B CS DUF3013 57 vseedivefedavlfyneak.skfd 80 +++e+ +ef d++l+ n ++ s+f gi|45356151|ref|NP_056076.1| 634 TVQEKALEFLDQLLLQNIRHhSHFH 658 57899999******99987756666 PP == domain 2 score: 15.9 bits; conditional E-value: 4.8e-06 HHHHHHHHHHHHHHHHHHHHHHTT-TT---------HHHHHHHHHHHCTT CS DUF3013 101 laalveyLqdvldegesdLldFleddekeeFelewdeeafeeilaelsee 150 l+ l++yL++v+++ +++L dF + d++ ele+d ++++e l + +e gi|45356151|ref|NP_056076.1| 1220 LRELMHYLREVMQDYRDELKDFFAVDKQLASELEYDMKKYQEQLVQEQEL 1269 6789************************************9998877664 PP >> VHS VHS domain # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? 10.7 0.0 0.00018 0.29 40 74 .. 538 572 .. 525 576 .. 0.90 2 ? 0.8 0.0 0.2 3.4e+02 66 105 .. 1176 1216 .. 1165 1250 .. 0.70 Alignments for each domain: == domain 1 score: 10.7 bits; conditional E-value: 0.00018 HHHHHHHHHHHHHT-SSHHHHHHHHHHHHHHHHHS CS VHS 40 gpkeavrlikkkinsknphvallaLklldalvkNc 74 g + ++ +++++i +++++v +aL++l ++ k+c gi|45356151|ref|NP_056076.1| 538 GERCVMAMLRRRIRDEKTNVRKSALQVLVSILKHC 572 5677899***************************9 PP == domain 2 score: 0.8 bits; conditional E-value: 0.2 HHHHHHHHSHHHHHHHHTSHHHHHHHHHHHHC.TTTCHCS. CS VHS 66 lldalvkNcGskfhleiaskeflnelvklile.kknsklak 105 l +++++ + +k+++++ +++f+++++ +i + k + +++k gi|45356151|ref|NP_056076.1| 1176 LANVVMQEAQKKLISQVQKRNFIENIIPIIISlKTVLEKNK 1216 66889999999**************9987765144444444 PP >> HEAT_EZ HEAT-like repeat # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -1.3 0.0 2.1 3.4e+03 4 52 .. 331 378 .. 329 381 .. 0.57 2 ? -1.7 0.0 2.7 4.4e+03 31 52 .. 544 565 .. 542 568 .. 0.69 3 ? 0.8 0.1 0.44 7.2e+02 40 54 .. 590 605 .. 555 611 .. 0.60 4 ? -2.0 0.0 3.4 5.6e+03 23 50 .. 633 671 .. 621 673 .. 0.59 5 ? 4.3 0.0 0.035 57 3 44 .. 919 955 .. 917 965 .. 0.82 6 ? 1.7 0.0 0.23 3.8e+02 30 55 .] 980 1005 .. 966 1005 .. 0.85 Alignments for each domain: == domain 1 score: -1.3 bits; conditional E-value: 2.1 HEAT_EZ 4 RraAawaLGrlaggaprllqpavpellpaLlalLeddddeVReaAawAL 52 R++A++ +++l + + + p v ll+ ++a d++e R+ Aa +L gi|45356151|ref|NP_056076.1| 331 RNQAVQFISALVDELKESIFPVVRILLQHICAKVV-DKSEYRTFAAQSL 378 78888888655544455555555555555554444.5555577777766 PP == domain 2 score: -1.7 bits; conditional E-value: 2.7 HEAT_EZ 31 paLlalLeddddeVReaAawAL 52 + L ++d++ VR++A+ L gi|45356151|ref|NP_056076.1| 544 AMLRRRIRDEKTNVRKSALQVL 565 5566677777778999987655 PP == domain 3 score: 0.8 bits; conditional E-value: 0.44 HEAT_EZ 40 ddd.eVReaAawALgr 54 d+ +VR++A+ +L++ gi|45356151|ref|NP_056076.1| 590 DPAvSVRKQALQSLTE 605 4445777777777765 PP == domain 4 score: -2.0 bits; conditional E-value: 3.4 HEAT_EZ 23 qpavpellpaLlalL.ed..........dddeVReaAaw 50 ++ ++++l++L +lL ++ dd++V + A++ gi|45356151|ref|NP_056076.1| 633 STVQEKALEFLDQLLlQNirhhshfhsgDDSQVLAWALL 671 455666677777666344555666665555566555555 PP == domain 5 score: 4.3 bits; conditional E-value: 0.035 HEAT_EZ 3 vRraAawaLGrlaggaprllqpavpellpaLlalLeddddeV 44 +R+ A+ +LG l+ + +l++ +p+l+ L +++V gi|45356151|ref|NP_056076.1| 919 IRAHAIITLGKLCLQHEDLAKKSIPALVRELE-----VCEDV 955 7999*********99******99999999998.....66644 PP == domain 6 score: 1.7 bits; conditional E-value: 0.23 HEAT_EZ 30 lpaLlalLeddddeVReaAawALgrl 55 +p ++ +L+d+d+ +R+++++ L++l gi|45356151|ref|NP_056076.1| 980 IPNISMCLKDSDPFIRKQTLILLTNL 1005 6677779999999**********986 PP >> DUF2435 Protein of unknown function (DUF2435) # score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc --- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ---- 1 ? -3.9 0.0 8 1.3e+04 64 80 .. 334 350 .. 324 363 .. 0.70 2 ? -2.4 0.0 2.7 4.4e+03 14 49 .. 454 487 .. 446 490 .. 0.72 3 ? -3.3 0.0 5.3 8.7e+03 27 55 .. 545 571 .. 543 573 .. 0.52 4 ? 7.0 0.0 0.0031 5.1 11 58 .. 586 633 .. 577 657 .. 0.70 5 ? 0.6 0.0 0.31 5.1e+02 20 40 .. 919 940 .. 913 952 .. 0.77 6 ? -0.2 0.0 0.55 9.1e+02 12 35 .. 986 1009 .. 975 1017 .. 0.81 Alignments for each domain: == domain 1 score: -3.9 bits; conditional E-value: 8 DUF2435 64 aikgLaalaevdpeevl 80 a++ ++al++ +e ++ gi|45356151|ref|NP_056076.1| 334 AVQFISALVDELKESIF 350 66777777766666544 PP == domain 2 score: -2.4 bits; conditional E-value: 2.7 DUF2435 14 ndplvPvrahgLllLrrlvekksedvadvpkilelf 49 d+ + vr+++L++ ++ +e + ++ilel+ gi|45356151|ref|NP_056076.1| 454 LDKAPTVRSKALSSFAHCLELTV--TSASESILELL 487 58899999999999998887665..44555555555 PP == domain 3 score: -3.3 bits; conditional E-value: 5.3 DUF2435 27 lLrrlvekksedvadvpkilelflsqlkd 55 +Lrr +++++ + ++ l++++s lk+ gi|45356151|ref|NP_056076.1| 545 MLRRRIRDEK--TNVRKSALQVLVSILKH 571 5666666665..33334555666666555 PP == domain 4 score: 7.0 bits; conditional E-value: 0.0031 DUF2435 11 kslndplvPvrahgLllLrrlvekksedvadvpkilelflsqlkdeds 58 ++ dp v+vr ++L++L++l++ + + v+ +++ l+ ++ + d +s gi|45356151|ref|NP_056076.1| 586 DQCRDPAVSVRKQALQSLTELLMAQPRCVQIQKAWLRGVVPVVMDCES 633 6778******************99985555555555555555555544 PP == domain 5 score: 0.6 bits; conditional E-value: 0.31 DUF2435 20 vrahgLllLrrlvekks.edva 40 +rah++++L +l +++ ++ gi|45356151|ref|NP_056076.1| 919 IRAHAIITLGKLCLQHEdLAKK 940 8***********9998843344 PP == domain 6 score: -0.2 bits; conditional E-value: 0.55 DUF2435 12 slndplvPvrahgLllLrrlvekk 35 l+d+ + +r + L+lL++l++++ gi|45356151|ref|NP_056076.1| 986 CLKDSDPFIRKQTLILLTNLLQEE 1009 588888999999999999998765 PP Internal pipeline statistics summary: ------------------------------------- Query sequence(s): 1 (1498 residues) Target model(s): 14831 (2610332 nodes) Passed MSV filter: 743 (0.0500978); expected 296.6 (0.02) Passed bias filter: 245 (0.0165195); expected 296.6 (0.02) Passed Vit filter: 31 (0.00209022); expected 14.8 (0.001) Passed Fwd filter: 9 (0.000606837); expected 0.1 (1e-05) Initial search space (Z): 14831 [actual number of targets] Domain search space (domZ): 9 [number of targets reported over threshold] # CPU time: 0.82u 21.92s 00:00:22.74 Elapsed: 00:00:35.57 # Mc/sec: 109.93 //