# species: Homo sapiens # support: EXP, IMP, ISS, ISM, TAS, IEA, HMP, HEP, IDA, IGI, ISO, IGC, NAS, HGI, IPI, IEP, ISA, RCA, IC, HDA # associations retrieved on: 2019-05-16 03:48:38-04 # gofunc built on: 2018-02-21 10:04:34.764444-05 # gene associations file: ftp://ftp.geneontology.org/pub/go/gene-associations/goa_human.gaf.gz # revision: 2018-02-02 $ # downloaded on: 2018-02-14 09:47:26-05 # GO DAG files from: http://archive.geneontology.org/latest-full/go_201512-termdb-tables.tar.gz # downloaded on: 2015-12-22 05:43:21-05 # translation required: yes # translation info: # authority: ensembl # synergizer db built on: 2015-11-17 14:24:21.26681-05 # synergizer db built from: Ensembl Genes 82 / Metazoa Mart / Plant Mart # namespace: hgnc_symbol # coverage: 99.8% # size of "genespace": 18224 # number of attributes: 20270 # NOTE: the last record consists of all the entities in the # "genespace" that are not associated with any attribute (for # the requested support). # Original number of entities in query: 274 # Number of entities in query: 274 # Total number of entities: 18233 # Original total number of entities: 18224 # Entities not in default gene space: 9 # Total number of attributes: 20270 # Translation required: yes # Translation coverage: 0.997782 # Mode: unordered # Number of simulations: 1000 # Adjusted P-value cutoff: 0.05 # Over/under: over # Evidence codes: EXP, IMP, ISS, ISM, TAS, IEA, HMP, HEP, IDA, IGI, ISO, IGC, NAS, HGI, IPI, IEP, ISA, RCA, IC, HDA OVERREPRESENTED ATTRIBUTES N X LOD P P_adj attrib ID attrib name 9 60 1.09491106208377 2.59336046120875e-07 <0.001 GO:1904356 regulation of telomere maintenance via telomere lengthening 11 89 0.997451511092333 9.35393150614399e-08 <0.001 GO:0006614 SRP-dependent cotranslational protein targeting to membrane 11 93 0.975770058968028 1.48076358809226e-07 <0.001 GO:0006613 cotranslational protein targeting to membrane 11 93 0.975770058968028 1.48076358809226e-07 <0.001 GO:0045047 protein targeting to ER 9 77 0.970615261155032 2.26492398443707e-06 0.005 GO:0032204 regulation of telomere maintenance 9 79 0.958068165365977 2.81486572947068e-06 0.007 GO:0051082 unfolded protein binding 11 97 0.955110717991946 2.2912002145483e-07 <0.001 GO:0072599 establishment of protein localization to endoplasmic reticulum 8 71 0.95371609182105 1.10149159159553e-05 0.038 GO:0048024 regulation of mRNA splicing, via spliceosome 9 81 0.945870720068199 3.47595005543524e-06 0.019 GO:0071013 catalytic step 2 spliceosome 11 100 0.940230889321199 3.13511726717208e-07 <0.001 GO:0070972 protein localization to endoplasmic reticulum 10 99 0.899077291214886 2.39573265133662e-06 0.006 GO:0045740 positive regulation of DNA replication 9 90 0.89483254996209 8.36468259354614e-06 0.029 GO:0043021 ribonucleoprotein complex binding 11 118 0.860207798300229 1.6687293671518e-06 0.003 GO:0006612 protein targeting to membrane 15 166 0.846409043769782 3.22820118968503e-08 <0.001 GO:0044445 cytosolic part 15 179 0.810338628579182 8.82318772020766e-08 <0.001 GO:0006275 regulation of DNA replication 12 146 0.800100141454108 2.1510824591135e-06 0.005 GO:0043209 myelin sheath 11 137 0.789063281402743 7.18011964082893e-06 0.026 GO:0006413 translational initiation 12 153 0.777895406793386 3.51392933017307e-06 0.019 GO:0051099 positive regulation of binding 15 214 0.725706623992585 8.89857966823977e-07 0.001 GO:0035239 tube morphogenesis 14 206 0.710755864869377 2.97277650383853e-06 0.008 GO:0051054 positive regulation of DNA metabolic process 18 270 0.703980226970926 1.50551919566742e-07 <0.001 GO:0072594 establishment of protein localization to organelle 15 225 0.702128359385555 1.67031943104555e-06 0.003 GO:0006605 protein targeting 29 450 0.698965387651167 4.52741825652664e-11 <0.001 GO:0031012 extracellular matrix 17 280 0.659367576190575 1.23814814370495e-06 0.001 GO:0002009 morphogenesis of an epithelium 18 298 0.657621471782613 6.45456572116816e-07 <0.001 GO:0045296 cadherin binding 22 373 0.649718167976863 5.42081401522885e-08 <0.001 GO:0051052 regulation of DNA metabolic process 21 361 0.642336959991638 1.38679912445631e-07 <0.001 GO:0007389 pattern specification process 24 425 0.631160216484079 3.01331228357656e-08 <0.001 GO:0033365 protein localization to organelle 20 355 0.626490354955807 4.6194020937124e-07 <0.001 GO:0048729 tissue morphogenesis 22 397 0.620441218358247 1.60994639851369e-07 <0.001 GO:0048598 embryonic morphogenesis 20 366 0.612208499162399 7.45944934313006e-07 0.001 GO:0044297 cell body 33 645 0.594258475075064 8.16959988312207e-10 <0.001 GO:0019904 protein domain specific binding 17 328 0.585510563589801 1.03122923871073e-05 0.038 GO:0072657 protein localization to membrane 22 432 0.580872721764645 6.77890890124716e-07 0.001 GO:0050839 cell adhesion molecule binding 34 690 0.577603241225511 1.17046228564135e-09 <0.001 GO:0034613 cellular protein localization 32 647 0.577105345471898 3.43808208499105e-09 <0.001 GO:0030529 intracellular ribonucleoprotein complex 32 650 0.574918574317601 3.84492747956747e-09 <0.001 GO:1990904 ribonucleoprotein complex 34 694 0.574864743496645 1.35774988983568e-09 <0.001 GO:0070727 cellular macromolecule localization 27 547 0.570870786028915 6.53278534848047e-08 <0.001 GO:0019901 protein kinase binding 66 1534 0.554101794241472 2.58315830705584e-15 <0.001 GO:0003723 RNA binding 23 488 0.545511722243943 1.4247041514258e-06 0.002 GO:0070161 anchoring junction 24 514 0.541999817528493 9.83561010662003e-07 0.001 GO:0006886 intracellular protein transport 29 628 0.541543561226273 8.67895028188362e-08 <0.001 GO:0019900 kinase binding 23 493 0.540747638909377 1.69330105438702e-06 0.004 GO:0008134 transcription factor binding 22 471 0.540489986821119 2.81373894231451e-06 0.007 GO:0005912 adherens junction 49 1169 0.518375984091433 5.09791618537256e-11 <0.001 GO:0048513 organ development 96 2721 0.499346690122728 7.07767114845419e-17 <0.001 GO:0070062 extracellular exosome 96 2722 0.499152985284904 7.25367522203466e-17 <0.001 GO:0065010 extracellular membrane-bounded organelle 54 1360 0.498384015792083 3.4061069521947e-11 <0.001 GO:0009653 anatomical structure morphogenesis 39 949 0.497037881263816 1.07636522638304e-08 <0.001 GO:0051641 cellular localization 96 2739 0.49586931340235 1.09894329066664e-16 <0.001 GO:1903561 extracellular vesicle 96 2740 0.495676701181135 1.12598693166447e-16 <0.001 GO:0043230 extracellular organelle 46 1167 0.485070871817938 1.59566107633303e-09 <0.001 GO:0030054 cell junction 27 667 0.477773706610758 3.11979369026991e-06 0.008 GO:1902580 single-organism cellular localization 113 3563 0.470593749949029 8.33008819212542e-17 <0.001 GO:0044421 extracellular region part 28 712 0.465085109818001 3.52753237967246e-06 0.019 GO:0043005 neuron projection 100 3118 0.45497364942604 7.32398544221148e-15 <0.001 GO:0031988 membrane-bounded vesicle 103 3303 0.444530039247477 1.4946299327858e-14 <0.001 GO:0031982 vesicle 49 1449 0.414222759054805 6.12987580711225e-08 <0.001 GO:0008104 protein localization 49 1462 0.409868983538257 8.07370822174965e-08 <0.001 GO:0033036 macromolecule localization 54 1693 0.391009947272169 7.96269423800188e-08 <0.001 GO:0019899 enzyme binding 46 1462 0.375977565405454 1.28054495955619e-06 0.001 GO:0042127 regulation of cell proliferation 39 1246 0.366798671345948 1.04084118107804e-05 0.038 GO:0097458 neuron part 45 1466 0.362977960352133 3.28595199326601e-06 0.01 GO:0070887 cellular response to chemical stimulus 40 1294 0.361700989229457 1.05958841626829e-05 0.038 GO:2000113 negative regulation of cellular macromolecule biosynthetic process 41 1330 0.361288491197872 8.64818425629684e-06 0.029 GO:0044877 macromolecular complex binding 53 1772 0.358177267138959 8.17279678101131e-07 0.001 GO:0045935 positive regulation of nucleobase-containing compound metabolic process 44 1470 0.349782104979206 8.16394400208053e-06 0.027 GO:0051172 negative regulation of nitrogen compound metabolic process 75 2706 0.343300335460673 4.97720039247866e-08 <0.001 GO:0048856 anatomical structure development 54 1877 0.339891483134579 2.07650732712177e-06 0.005 GO:0051173 positive regulation of nitrogen compound metabolic process 113 4539 0.332172993585188 1.65220885631277e-09 <0.001 GO:0016043 cellular component organization 113 4559 0.329572884184662 2.16772405697019e-09 <0.001 GO:0071840 cellular component organization or biogenesis 113 4677 0.314389052156736 1.02064849786016e-08 <0.001 GO:0032502 developmental process 105 4303 0.309654374040433 3.00817715040783e-08 <0.001 GO:0044767 single-organism developmental process 62 2340 0.306259652428853 4.73255548567539e-06 0.019 GO:0042221 response to chemical 59 2241 0.300153627701005 1.04450850740728e-05 0.038 GO:0051128 regulation of cellular component organization 61 2327 0.299841324750244 8.1102123357269e-06 0.027 GO:0050793 regulation of developmental process 63 2445 0.29292820419735 9.59205057094233e-06 0.032 GO:0043228 non-membrane-bounded organelle 63 2445 0.29292820419735 9.59205057094233e-06 0.032 GO:0043232 intracellular non-membrane-bounded organelle 89 3648 0.290467695594793 6.60393666297612e-07 <0.001 GO:0003676 nucleic acid binding 207 11196 0.290000326398278 4.17033059994193e-07 <0.001 GO:0044699 single-organism process 65 2555 0.288247003426433 1.00528149978654e-05 0.038 GO:0043168 anion binding 123 5471 0.283789068841349 1.15439318310709e-07 <0.001 GO:1901363 heterocyclic compound binding 124 5538 0.282562468223142 1.24325685363516e-07 <0.001 GO:0097159 organic cyclic compound binding 180 9467 0.25129087947788 2.33687514377955e-06 0.006 GO:0044763 single-organism cellular process 146 7290 0.237009258105968 4.9998762664452e-06 0.019 GO:0016020 membrane