#DataSet: file2_H3K9me2_MPP8-KO file2_H3K9me2_WT file2_H3K9me3_MORC2-KO file2_H3K9me3_MPP8-KO file2_H3K9me3_TASOR-KO file2_H3K9me3_WT file2_MORC2_MORC2-KO file2_MORC2_MPP8-KO file2_MORC2_TASOR-KO file2_MORC2_WT file2_MORC2_hESC_WT file2_MPP8_MORC2-KO file2_MPP8_MPP8-KO file2_MPP8_TASOR-KO file2_MPP8_WT file2_MPP8_hESC_WT file2_MPP8_mESC_WT file2_PolII_K562_MORC2-KO file2_PolII_K562_MPP8-KO file2_PolII_K562_TASOR-KO file2_PolII_K562_WT file2_TASOR_MORC2-KO file2_TASOR_MPP8-KO file2_TASOR_TASOR-KO file2_TASOR_WT Regions 22 111 25741 16713 18353 28725 0 236 542 2777 8302 234 115 196 219 7382 0 19085 20279 19712 24126 360 212 338 264 H3K9me2_MPP8-KO 22 1.0 0.363636363636 0.409090909091 0.454545454545 0.272727272727 0.545454545455 0 0.136363636364 0.0909090909091 0.0 0.0909090909091 0.0909090909091 0.0454545454545 0.0454545454545 0.0454545454545 0.0454545454545 0 0.0 0.0 0.0909090909091 0.0 0.0909090909091 0.0909090909091 0.0454545454545 0.0 H3K9me2_WT 111 0.0720720720721 1.0 0.225225225225 0.225225225225 0.126126126126 0.27027027027 0 0.045045045045 0.036036036036 0.027027027027 0.036036036036 0.036036036036 0.018018018018 0.018018018018 0.027027027027 0.018018018018 0 0.0900900900901 0.117117117117 0.117117117117 0.153153153153 0.036036036036 0.027027027027 0.018018018018 0.018018018018 H3K9me3_MORC2-KO 25741 0.000388485295832 0.00101006176916 1.0 0.358066897168 0.45013791228 0.621809564508 0 0.00493376325706 0.00423448972456 0.0270774251195 0.0230371780428 0.00555533973039 0.00209782059749 0.00244745736374 0.00384600442873 0.0794840915271 0 0.0297191251311 0.0297579736607 0.0283205780661 0.0680237753001 0.00489491472748 0.00104891029875 0.000582727943747 0.00256400295249 H3K9me3_MPP8-KO 16713 0.000598336624185 0.00149584156046 0.552922874409 1.0 0.53018608269 0.705199545264 0 0.00831687907617 0.00789804343924 0.0375157063364 0.0439777418776 0.00532519595524 0.00335068509543 0.00508586130557 0.00520552863041 0.0947765212709 0 0.0625261772273 0.0659366959852 0.0750314126728 0.138694429486 0.00538502961766 0.00119667324837 0.000897504936277 0.00353018608269 H3K9me3_TASOR-KO 18353 0.000381409033945 0.000762818067891 0.62191467335 0.475235656296 1.0 0.704789407726 0 0.00653844058192 0.00577562251403 0.0297499046477 0.0328556639242 0.00544870048493 0.00283332425217 0.00381409033945 0.0043044733831 0.0872881817686 0 0.0354710401569 0.0368332152782 0.0388492344576 0.0836920394486 0.00512177845584 0.00136217512123 0.000708331063041 0.00326922029096 H3K9me3_WT 28725 0.000417754569191 0.000974760661445 0.499878154917 0.370374238468 0.419321148825 1.0 0 0.00476936466493 0.0045953002611 0.0450130548303 0.038955613577 0.00487380330722 0.00194952132289 0.00341166231506 0.00598781549173 0.0821235857267 0 0.0528459530026 0.0553872932985 0.0575108790252 0.104473455178 0.00494342906876 0.000870322019147 0.000522193211488 0.00403829416884 MORC2_MORC2-KO 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 MORC2_MPP8-KO 236 0.0127118644068 0.021186440678 0.584745762712 0.635593220339 0.555084745763 0.631355932203 0 1.0 0.64406779661 0.631355932203 0.559322033898 0.0677966101695 0.0635593220339 0.0466101694915 0.0847457627119 0.402542372881 0 0.457627118644 0.474576271186 0.449152542373 0.597457627119 0.0254237288136 0.0338983050847 0.0254237288136 0.0593220338983 MORC2_TASOR-KO 542 0.00369003690037 0.00738007380074 0.20479704797 0.252767527675 0.20479704797 0.250922509225 0 0.276752767528 1.0 0.383763837638 0.643911439114 0.0258302583026 0.0350553505535 0.029520295203 0.0350553505535 0.190036900369 0 0.712177121771 0.721402214022 0.743542435424 0.80258302583 0.0166051660517 0.0166051660517 0.020295202952 0.0221402214022 MORC2_WT 2777 0.0 0.0010803024847 0.235505941664 0.225063017645 0.195174648902 0.473532589125 0 0.0518545192654 0.0752610731005 1.0 0.412675549154 0.0288080662586 0.00468131076701 0.00648181490817 0.054375225063 0.296362981635 0 0.531868923299 0.546633057256 0.527187612532 0.633777457688 0.0115232265034 0.00432120993878 0.00648181490817 0.0360100828232 MORC2_hESC_WT 8302 0.00024090580583 0.00048181161166 0.0675740785353 0.0870874488075 0.073717176584 0.140809443508 0 0.0151770657673 0.0414357986027 0.139484461576 1.0 0.00662490966032 0.00204769934955 0.00337268128162 0.0103589496507 0.198988195616 0 0.387737894483 0.395326427367 0.407973982173 0.452662009154 0.0048181161166 0.00349313418453 0.00650445675741 0.0102384967478 MPP8_MORC2-KO 234 0.00854700854701 0.017094017094 0.576923076923 0.376068376068 0.431623931624 0.666666666667 0 0.0683760683761 0.0598290598291 0.367521367521 0.235042735043 1.0 0.0555555555556 0.175213675214 0.299145299145 0.363247863248 0 0.34188034188 0.324786324786 0.282051282051 0.371794871795 0.311965811966 0.0384615384615 0.0299145299145 0.205128205128 MPP8_MPP8-KO 115 0.00869565217391 0.0173913043478 0.504347826087 0.486956521739 0.469565217391 0.504347826087 0 0.121739130435 0.165217391304 0.113043478261 0.147826086957 0.113043478261 1.0 0.2 0.0782608695652 0.539130434783 0 0.260869565217 0.252173913043 0.304347826087 0.321739130435 0.104347826087 0.104347826087 0.0521739130435 0.0869565217391 MPP8_TASOR-KO 196 0.00510204081633 0.0102040816327 0.321428571429 0.413265306122 0.34693877551 0.479591836735 0 0.0561224489796 0.0816326530612 0.0918367346939 0.142857142857 0.198979591837 0.117346938776 1.0 0.15306122449 0.392857142857 0 0.204081632653 0.265306122449 0.219387755102 0.275510204082 0.0867346938776 0.0459183673469 0.0510204081633 0.0510204081633 MPP8_WT 219 0.00456621004566 0.013698630137 0.433789954338 0.397260273973 0.369863013699 0.7899543379 0 0.0913242009132 0.0913242009132 0.748858447489 0.41095890411 0.315068493151 0.0502283105023 0.146118721461 1.0 0.602739726027 0 0.525114155251 0.506849315068 0.465753424658 0.684931506849 0.0776255707763 0.0182648401826 0.013698630137 0.333333333333 MPP8_hESC_WT 7382 0.000135464643728 0.000270929287456 0.27214846925 0.223652126795 0.227038742888 0.35139528583 0 0.0123272825792 0.013952858304 0.119615280412 0.225955025738 0.0113790300732 0.00880520184232 0.0111081007857 0.0178813329721 1.0 0 0.257382823083 0.252235166622 0.25507992414 0.376320780276 0.00568951503658 0.00149011108101 0.00162557572474 0.0116499593606 MPP8_mESC_WT 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 PolII_K562_MORC2-KO 19085 0.0 0.000523971705528 0.0353680901231 0.0531307309405 0.0331150117894 0.0777050039298 0 0.00539690856694 0.0197537332984 0.0753471312549 0.160859313597 0.00372019910925 0.00157191511658 0.00209588682211 0.0055541000786 0.0857217710244 0 1.0 0.819229761593 0.838616714697 0.933560387739 0.00628766046633 0.00628766046633 0.0118941577155 0.00916950484674 PolII_K562_MPP8-KO 20279 0.0 0.000641057251344 0.0335322254549 0.0529611913802 0.0324966714335 0.0773706790276 0 0.00532570639578 0.0187385965777 0.073425711327 0.154494797574 0.00330391044923 0.00147936288772 0.00261354110163 0.00507914591449 0.0793431628779 0 0.773460229794 1.0 0.824843434094 0.915972187978 0.00586813945461 0.00621332412841 0.0118349031017 0.00892548942256 PolII_K562_TASOR-KO 19712 0.000101461038961 0.000659496753247 0.0335328733766 0.0617897727273 0.0354606331169 0.0803064123377 0 0.00522524350649 0.0198356331169 0.0720880681818 0.160511363636 0.00299310064935 0.00187702922078 0.00218141233766 0.00466720779221 0.0804586038961 0 0.763950892857 0.79788961039 1.0 0.927607548701 0.00603693181818 0.00654423701299 0.0126318993506 0.00877637987013 PolII_K562_WT 24126 0.0 0.000704634004808 0.0628782226643 0.0898615601426 0.0598109922905 0.11734228633 0 0.00547127580204 0.0172013595291 0.0684738456437 0.141092597198 0.0032744756694 0.00153361518694 0.00223824919174 0.00563707203846 0.0945867528807 0 0.613114482301 0.638605653652 0.655516869767 1.0 0.00518113238829 0.00559562297936 0.010528061013 0.00816546464395 TASOR_MORC2-KO 360 0.00555555555556 0.0111111111111 0.341666666667 0.247222222222 0.258333333333 0.408333333333 0 0.0138888888889 0.0277777777778 0.0944444444444 0.105555555556 0.202777777778 0.0305555555556 0.05 0.05 0.111111111111 0 0.333333333333 0.333333333333 0.336111111111 0.358333333333 1.0 0.305555555556 0.291666666667 0.355555555556 TASOR_MPP8-KO 212 0.00943396226415 0.0141509433962 0.13679245283 0.103773584906 0.122641509434 0.132075471698 0 0.0377358490566 0.0424528301887 0.061320754717 0.13679245283 0.0424528301887 0.0566037735849 0.0424528301887 0.0188679245283 0.0518867924528 0 0.570754716981 0.599056603774 0.61320754717 0.646226415094 0.518867924528 1.0 0.693396226415 0.52358490566 TASOR_TASOR-KO 338 0.00295857988166 0.00591715976331 0.0443786982249 0.0384615384615 0.0325443786982 0.0414201183432 0 0.0177514792899 0.0325443786982 0.0502958579882 0.156804733728 0.0207100591716 0.0177514792899 0.0295857988166 0.00887573964497 0.0384615384615 0 0.671597633136 0.710059171598 0.742603550296 0.757396449704 0.310650887574 0.426035502959 1.0 0.340236686391 TASOR_WT 264 0.0 0.00757575757576 0.253787878788 0.208333333333 0.219696969697 0.443181818182 0 0.0530303030303 0.0492424242424 0.401515151515 0.310606060606 0.189393939394 0.0378787878788 0.0378787878788 0.272727272727 0.329545454545 0 0.681818181818 0.700757575758 0.670454545455 0.784090909091 0.488636363636 0.420454545455 0.439393939394 1.0