[M::bwa_idx_load_from_disk] read 0 ALT contigs [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12783, 79171, 12856, 12625) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (497, 1316, 3474) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9428) [M::mem_pestat] mean and std.dev: (2265.94, 2351.51) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12405) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (208, 295, 428) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 868) [M::mem_pestat] mean and std.dev: (298.60, 145.44) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1088) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (342, 1199, 3562) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10002) [M::mem_pestat] mean and std.dev: (2335.77, 2617.92) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13222) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (479, 1302, 3449) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9389) [M::mem_pestat] mean and std.dev: (2253.89, 2362.80) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12359) [M::process] read 1333334 sequences (200000100 bp)... [M::mem_process_seqs] Processed 1333334 reads in 500.772 CPU sec, 70.226 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12855, 78281, 12635, 12860) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (491, 1369, 3617) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9869) [M::mem_pestat] mean and std.dev: (2391.44, 2492.03) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12995) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 298, 434) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 880) [M::mem_pestat] mean and std.dev: (302.21, 147.04) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1103) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (330, 1169, 3459) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9717) [M::mem_pestat] mean and std.dev: (2234.66, 2528.32) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12846) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (475, 1291, 3547) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9691) [M::mem_pestat] mean and std.dev: (2330.95, 2465.21) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12763) [M::mem_process_seqs] Processed 1333334 reads in 443.704 CPU sec, 29.511 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12581, 77791, 12656, 12599) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (481, 1323, 3621) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9901) [M::mem_pestat] mean and std.dev: (2384.80, 2494.42) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13041) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 298, 433) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 877) [M::mem_pestat] mean and std.dev: (301.68, 147.20) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1099) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (290, 1104, 3250) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9170) [M::mem_pestat] mean and std.dev: (2052.90, 2342.87) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12130) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (468, 1281, 3577) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9795) [M::mem_pestat] mean and std.dev: (2369.55, 2518.25) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12904) [M::mem_process_seqs] Processed 1333334 reads in 448.807 CPU sec, 29.364 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12493, 77098, 12638, 12656) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (482, 1315, 3646) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9974) [M::mem_pestat] mean and std.dev: (2432.30, 2564.05) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13138) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 300, 435) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 885) [M::mem_pestat] mean and std.dev: (303.15, 148.37) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1110) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (297, 1132, 3364) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9498) [M::mem_pestat] mean and std.dev: (2132.27, 2430.46) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12565) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (476, 1302, 3564) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9740) [M::mem_pestat] mean and std.dev: (2359.26, 2492.41) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12828) [M::mem_process_seqs] Processed 1333334 reads in 444.795 CPU sec, 28.996 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12517, 76448, 12587, 12305) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (491, 1329, 3600) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9818) [M::mem_pestat] mean and std.dev: (2366.82, 2471.24) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12927) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 300, 439) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 893) [M::mem_pestat] mean and std.dev: (303.33, 148.08) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1120) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (327, 1161, 3435) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9651) [M::mem_pestat] mean and std.dev: (2191.51, 2469.06) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12759) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (487, 1337, 3619) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9883) [M::mem_pestat] mean and std.dev: (2388.25, 2505.48) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13015) [M::mem_process_seqs] Processed 1333334 reads in 453.068 CPU sec, 29.549 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12673, 76579, 12745, 12455) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (497, 1323, 3574) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9728) [M::mem_pestat] mean and std.dev: (2347.59, 2458.79) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12805) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 300, 439) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 893) [M::mem_pestat] mean and std.dev: (304.53, 149.49) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1120) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (306, 1171, 3463) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9777) [M::mem_pestat] mean and std.dev: (2210.72, 2497.61) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12934) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (492, 1347, 3543) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9645) [M::mem_pestat] mean and std.dev: (2338.45, 2438.50) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12696) [M::mem_process_seqs] Processed 1333334 reads in 445.156 CPU sec, 28.445 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12516, 77433, 12844, 12545) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (497, 1315, 3563) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9695) [M::mem_pestat] mean and std.dev: (2338.01, 2459.99) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12761) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 301, 439) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 895) [M::mem_pestat] mean and std.dev: (303.71, 149.10) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1123) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (318, 1175, 3540) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9984) [M::mem_pestat] mean and std.dev: (2279.50, 2557.63) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13206) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (482, 1325, 3571) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9749) [M::mem_pestat] mean and std.dev: (2343.21, 2457.67) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12838) [M::mem_process_seqs] Processed 1333334 reads in 442.266 CPU sec, 28.304 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12558, 76628, 12777, 12517) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (479, 1319, 3585) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9797) [M::mem_pestat] mean and std.dev: (2345.27, 2466.34) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12903) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 302, 440) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 898) [M::mem_pestat] mean and std.dev: (305.11, 150.14) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1127) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (308, 1135, 3367) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9485) [M::mem_pestat] mean and std.dev: (2128.60, 2408.22) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12544) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (490, 1344, 3609) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9847) [M::mem_pestat] mean and std.dev: (2395.53, 2503.71) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12966) [M::mem_process_seqs] Processed 1333334 reads in 450.544 CPU sec, 29.280 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12496, 77119, 12865, 12727) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (498, 1364, 3690) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10074) [M::mem_pestat] mean and std.dev: (2444.78, 2547.84) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13266) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 302, 440) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 896) [M::mem_pestat] mean and std.dev: (305.54, 150.17) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1124) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (300, 1128, 3485) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9855) [M::mem_pestat] mean and std.dev: (2235.68, 2554.71) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13040) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (489, 1360, 3617) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9873) [M::mem_pestat] mean and std.dev: (2396.65, 2495.14) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13001) [M::mem_process_seqs] Processed 1333334 reads in 446.513 CPU sec, 28.498 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12362, 76717, 12641, 12424) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (489, 1370, 3603) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9831) [M::mem_pestat] mean and std.dev: (2408.58, 2509.65) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12945) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 299, 438) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 892) [M::mem_pestat] mean and std.dev: (303.46, 149.25) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1119) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (294, 1103, 3359) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9489) [M::mem_pestat] mean and std.dev: (2109.65, 2406.78) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12554) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (493, 1349, 3625) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9889) [M::mem_pestat] mean and std.dev: (2404.66, 2500.31) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13021) [M::mem_process_seqs] Processed 1333334 reads in 449.408 CPU sec, 28.550 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12654, 76205, 12767, 12570) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (482, 1302, 3556) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9704) [M::mem_pestat] mean and std.dev: (2345.69, 2478.05) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12778) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 303, 444) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 906) [M::mem_pestat] mean and std.dev: (306.88, 150.53) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1137) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (316, 1139, 3423) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9637) [M::mem_pestat] mean and std.dev: (2186.70, 2467.65) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12744) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (492, 1321, 3561) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9699) [M::mem_pestat] mean and std.dev: (2349.35, 2469.64) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12768) [M::mem_process_seqs] Processed 1333334 reads in 448.658 CPU sec, 28.661 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12437, 76012, 12738, 12506) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (486, 1302, 3459) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9405) [M::mem_pestat] mean and std.dev: (2251.29, 2360.73) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12378) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 301, 441) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 899) [M::mem_pestat] mean and std.dev: (304.91, 149.64) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1128) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (300, 1137, 3368) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9504) [M::mem_pestat] mean and std.dev: (2143.70, 2431.25) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12572) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (485, 1307, 3594) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9812) [M::mem_pestat] mean and std.dev: (2365.70, 2505.26) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12921) [M::mem_process_seqs] Processed 1333334 reads in 444.727 CPU sec, 28.205 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12657, 75674, 12639, 12367) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (480, 1290, 3600) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9840) [M::mem_pestat] mean and std.dev: (2381.57, 2526.09) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12960) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 303, 443) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 903) [M::mem_pestat] mean and std.dev: (307.05, 150.23) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1133) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (289, 1145, 3421) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9685) [M::mem_pestat] mean and std.dev: (2184.30, 2482.31) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12817) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (480, 1341, 3608) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9864) [M::mem_pestat] mean and std.dev: (2389.76, 2509.17) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12992) [M::mem_process_seqs] Processed 1333334 reads in 449.196 CPU sec, 28.740 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12470, 75573, 12811, 12432) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (494, 1365, 3659) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9989) [M::mem_pestat] mean and std.dev: (2438.88, 2542.27) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13154) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 304, 444) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 904) [M::mem_pestat] mean and std.dev: (307.41, 150.95) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1134) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (291, 1131, 3429) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9705) [M::mem_pestat] mean and std.dev: (2179.70, 2474.55) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12843) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (490, 1339, 3618) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9874) [M::mem_pestat] mean and std.dev: (2396.37, 2515.50) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13002) [M::mem_process_seqs] Processed 1333334 reads in 446.302 CPU sec, 28.876 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12382, 74720, 12678, 12263) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (491, 1359, 3562) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9704) [M::mem_pestat] mean and std.dev: (2341.88, 2428.52) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12775) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 305, 449) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 919) [M::mem_pestat] mean and std.dev: (309.66, 153.58) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1154) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (304, 1176, 3339) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9409) [M::mem_pestat] mean and std.dev: (2124.88, 2388.60) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12444) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (481, 1328, 3647) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9979) [M::mem_pestat] mean and std.dev: (2408.06, 2534.76) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13145) [M::mem_process_seqs] Processed 1333334 reads in 451.197 CPU sec, 28.683 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12390, 74815, 12740, 12294) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (483, 1299, 3500) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9534) [M::mem_pestat] mean and std.dev: (2278.28, 2390.77) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12551) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (216, 307, 453) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 927) [M::mem_pestat] mean and std.dev: (311.79, 154.84) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1164) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (310, 1146, 3427) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9661) [M::mem_pestat] mean and std.dev: (2191.69, 2469.20) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12778) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (485, 1297, 3515) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9575) [M::mem_pestat] mean and std.dev: (2299.06, 2413.99) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12605) [M::mem_process_seqs] Processed 1333334 reads in 446.618 CPU sec, 28.339 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12475, 74917, 12692, 12610) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (465, 1295, 3526) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9648) [M::mem_pestat] mean and std.dev: (2294.42, 2411.33) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12709) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 305, 446) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 910) [M::mem_pestat] mean and std.dev: (308.39, 151.55) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1142) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (303, 1137, 3256) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9162) [M::mem_pestat] mean and std.dev: (2056.46, 2330.71) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12115) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (499, 1338, 3526) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9580) [M::mem_pestat] mean and std.dev: (2312.55, 2393.09) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12607) [M::mem_process_seqs] Processed 1333334 reads in 445.390 CPU sec, 28.340 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12448, 74612, 12827, 12407) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (481, 1338, 3605) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9853) [M::mem_pestat] mean and std.dev: (2382.57, 2501.96) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12977) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (215, 305, 448) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 914) [M::mem_pestat] mean and std.dev: (308.52, 151.56) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1147) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (304, 1125, 3415) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9637) [M::mem_pestat] mean and std.dev: (2174.17, 2468.60) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12748) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (487, 1334, 3670) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10036) [M::mem_pestat] mean and std.dev: (2438.30, 2551.04) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13219) [M::mem_process_seqs] Processed 1333334 reads in 447.404 CPU sec, 28.363 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12439, 77309, 12648, 12561) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (465, 1298, 3478) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9504) [M::mem_pestat] mean and std.dev: (2275.07, 2399.12) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12517) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 301, 440) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 896) [M::mem_pestat] mean and std.dev: (305.18, 150.01) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1124) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (312, 1173, 3455) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9741) [M::mem_pestat] mean and std.dev: (2230.23, 2522.33) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12884) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (482, 1311, 3564) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9728) [M::mem_pestat] mean and std.dev: (2337.79, 2459.01) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12810) [M::mem_process_seqs] Processed 1333334 reads in 445.875 CPU sec, 28.410 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12400, 77725, 12795, 12602) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (493, 1335, 3500) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9514) [M::mem_pestat] mean and std.dev: (2290.92, 2380.55) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12521) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 299, 438) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 894) [M::mem_pestat] mean and std.dev: (302.38, 149.19) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1122) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (327, 1184, 3479) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9783) [M::mem_pestat] mean and std.dev: (2234.22, 2505.21) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12935) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (486, 1346, 3523) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9597) [M::mem_pestat] mean and std.dev: (2327.27, 2427.50) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12634) [M::mem_process_seqs] Processed 1333334 reads in 439.382 CPU sec, 28.336 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12841, 76926, 12516, 12531) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (488, 1371, 3634) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9926) [M::mem_pestat] mean and std.dev: (2415.02, 2524.53) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13072) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 300, 438) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 894) [M::mem_pestat] mean and std.dev: (302.76, 148.66) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1122) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (342, 1191, 3424) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9588) [M::mem_pestat] mean and std.dev: (2202.58, 2451.33) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12670) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (501, 1363, 3623) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9867) [M::mem_pestat] mean and std.dev: (2417.34, 2511.07) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12989) [M::mem_process_seqs] Processed 1333334 reads in 476.200 CPU sec, 30.320 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12216, 75236, 12470, 12532) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (476, 1270, 3547) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9689) [M::mem_pestat] mean and std.dev: (2319.19, 2454.12) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12760) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 298, 436) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 888) [M::mem_pestat] mean and std.dev: (301.70, 147.60) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1114) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (323, 1149, 3417) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9605) [M::mem_pestat] mean and std.dev: (2184.10, 2451.58) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12699) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (497, 1324, 3621) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9869) [M::mem_pestat] mean and std.dev: (2382.98, 2500.24) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12993) [M::mem_process_seqs] Processed 1333334 reads in 468.494 CPU sec, 29.759 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12691, 76311, 13060, 12762) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (489, 1339, 3556) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9690) [M::mem_pestat] mean and std.dev: (2337.95, 2449.04) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12757) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 303, 443) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 903) [M::mem_pestat] mean and std.dev: (306.16, 151.03) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1133) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (313, 1141, 3422) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9640) [M::mem_pestat] mean and std.dev: (2170.35, 2454.02) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12749) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (491, 1333, 3477) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9449) [M::mem_pestat] mean and std.dev: (2258.87, 2345.52) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12435) [M::mem_process_seqs] Processed 1333334 reads in 458.416 CPU sec, 29.153 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12573, 77013, 12562, 12304) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (489, 1361, 3697) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10113) [M::mem_pestat] mean and std.dev: (2447.92, 2559.08) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13321) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 299, 434) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 882) [M::mem_pestat] mean and std.dev: (302.25, 147.79) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1106) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (311, 1172, 3427) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9659) [M::mem_pestat] mean and std.dev: (2195.37, 2475.04) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12775) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (493, 1347, 3591) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9787) [M::mem_pestat] mean and std.dev: (2362.10, 2456.78) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12885) [M::mem_process_seqs] Processed 1333334 reads in 473.322 CPU sec, 30.236 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12635, 77216, 12721, 12509) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (464, 1293, 3537) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9683) [M::mem_pestat] mean and std.dev: (2320.05, 2453.41) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12756) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 302, 443) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 905) [M::mem_pestat] mean and std.dev: (306.29, 150.33) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1136) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (305, 1126, 3381) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9533) [M::mem_pestat] mean and std.dev: (2129.57, 2419.10) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12609) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (495, 1347, 3481) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9453) [M::mem_pestat] mean and std.dev: (2295.36, 2392.72) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12439) [M::mem_process_seqs] Processed 1333334 reads in 454.556 CPU sec, 29.054 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12652, 76124, 12898, 12409) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (492, 1305, 3559) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9693) [M::mem_pestat] mean and std.dev: (2332.48, 2437.41) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12760) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 301, 440) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 898) [M::mem_pestat] mean and std.dev: (304.56, 150.29) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1127) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (332, 1199, 3528) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9920) [M::mem_pestat] mean and std.dev: (2295.61, 2572.91) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13116) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (485, 1380, 3670) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10040) [M::mem_pestat] mean and std.dev: (2429.73, 2539.65) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13225) [M::mem_process_seqs] Processed 1333334 reads in 449.549 CPU sec, 28.558 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12423, 76487, 12748, 12425) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (491, 1333, 3559) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9695) [M::mem_pestat] mean and std.dev: (2353.51, 2476.18) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12763) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 305, 447) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 913) [M::mem_pestat] mean and std.dev: (308.86, 151.87) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1146) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (304, 1138, 3388) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9556) [M::mem_pestat] mean and std.dev: (2153.34, 2439.24) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12640) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (489, 1306, 3507) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9543) [M::mem_pestat] mean and std.dev: (2293.92, 2401.08) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12561) [M::mem_process_seqs] Processed 1333334 reads in 444.043 CPU sec, 28.214 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12519, 74781, 12641, 12384) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (474, 1309, 3556) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9720) [M::mem_pestat] mean and std.dev: (2334.37, 2460.56) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12802) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 302, 442) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 900) [M::mem_pestat] mean and std.dev: (305.76, 150.29) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1129) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (290, 1136, 3431) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9713) [M::mem_pestat] mean and std.dev: (2188.82, 2497.83) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12854) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (484, 1341, 3631) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9925) [M::mem_pestat] mean and std.dev: (2402.22, 2524.33) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13072) [M::mem_process_seqs] Processed 1333334 reads in 448.899 CPU sec, 28.517 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12415, 75908, 12635, 12617) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (487, 1339, 3588) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9790) [M::mem_pestat] mean and std.dev: (2362.30, 2482.35) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12891) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 304, 446) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 910) [M::mem_pestat] mean and std.dev: (308.30, 151.81) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1142) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (293, 1101, 3342) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9440) [M::mem_pestat] mean and std.dev: (2112.58, 2429.08) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12489) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (488, 1317, 3584) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9776) [M::mem_pestat] mean and std.dev: (2356.75, 2477.89) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12872) [M::mem_process_seqs] Processed 1333334 reads in 447.684 CPU sec, 28.566 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12439, 75249, 12632, 12556) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (487, 1322, 3622) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9892) [M::mem_pestat] mean and std.dev: (2392.03, 2504.28) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13027) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (215, 305, 446) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 908) [M::mem_pestat] mean and std.dev: (309.32, 151.69) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1139) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (306, 1165, 3381) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9531) [M::mem_pestat] mean and std.dev: (2137.42, 2419.13) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12606) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (496, 1377, 3596) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9796) [M::mem_pestat] mean and std.dev: (2367.62, 2454.31) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12896) [M::mem_process_seqs] Processed 1333334 reads in 447.734 CPU sec, 28.483 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12625, 75831, 12626, 12471) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (497, 1364, 3689) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10073) [M::mem_pestat] mean and std.dev: (2447.30, 2557.38) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13265) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 304, 447) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 913) [M::mem_pestat] mean and std.dev: (308.37, 151.66) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1146) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (300, 1177, 3484) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9852) [M::mem_pestat] mean and std.dev: (2267.49, 2571.04) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13036) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (487, 1299, 3528) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9610) [M::mem_pestat] mean and std.dev: (2305.72, 2422.72) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12651) [M::mem_process_seqs] Processed 1333334 reads in 447.778 CPU sec, 28.457 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12599, 74803, 12522, 12456) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (475, 1272, 3485) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9505) [M::mem_pestat] mean and std.dev: (2258.70, 2393.71) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12515) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 305, 445) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 907) [M::mem_pestat] mean and std.dev: (308.82, 151.94) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1138) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (302, 1173, 3395) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9581) [M::mem_pestat] mean and std.dev: (2173.48, 2464.72) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12674) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (495, 1334, 3596) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9798) [M::mem_pestat] mean and std.dev: (2382.34, 2493.95) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12899) [M::mem_process_seqs] Processed 1333334 reads in 454.835 CPU sec, 28.890 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12519, 75379, 12678, 12284) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (479, 1325, 3519) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9599) [M::mem_pestat] mean and std.dev: (2304.20, 2402.30) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12639) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 303, 445) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 909) [M::mem_pestat] mean and std.dev: (307.64, 152.02) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1141) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (324, 1194, 3449) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9699) [M::mem_pestat] mean and std.dev: (2224.37, 2500.62) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12824) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (489, 1365, 3612) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9858) [M::mem_pestat] mean and std.dev: (2399.24, 2492.57) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12981) [M::mem_process_seqs] Processed 1333334 reads in 450.689 CPU sec, 28.828 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12573, 76261, 12646, 12585) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (490, 1310, 3519) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9577) [M::mem_pestat] mean and std.dev: (2302.91, 2394.66) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12606) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 300, 438) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 892) [M::mem_pestat] mean and std.dev: (303.39, 148.51) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1119) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (316, 1149, 3354) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9430) [M::mem_pestat] mean and std.dev: (2128.87, 2408.60) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12468) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (494, 1368, 3689) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10079) [M::mem_pestat] mean and std.dev: (2456.48, 2561.92) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13274) [M::mem_process_seqs] Processed 1333334 reads in 452.058 CPU sec, 28.808 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12451, 76455, 12887, 12401) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (471, 1316, 3567) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9759) [M::mem_pestat] mean and std.dev: (2340.12, 2462.06) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12855) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 302, 439) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 891) [M::mem_pestat] mean and std.dev: (305.18, 148.44) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1117) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (303, 1169, 3442) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9720) [M::mem_pestat] mean and std.dev: (2215.45, 2501.07) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12859) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (497, 1352, 3626) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9884) [M::mem_pestat] mean and std.dev: (2413.48, 2522.12) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13013) [M::mem_process_seqs] Processed 1333334 reads in 445.928 CPU sec, 28.346 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12451, 76288, 12759, 12456) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (483, 1328, 3527) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9615) [M::mem_pestat] mean and std.dev: (2321.01, 2424.91) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12659) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 302, 443) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 905) [M::mem_pestat] mean and std.dev: (306.37, 151.40) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1136) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (311, 1131, 3431) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9671) [M::mem_pestat] mean and std.dev: (2188.77, 2489.61) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12791) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (491, 1326, 3543) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9647) [M::mem_pestat] mean and std.dev: (2339.69, 2449.86) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12699) [M::mem_process_seqs] Processed 1333334 reads in 449.966 CPU sec, 28.681 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12660, 76589, 12901, 12584) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (485, 1331, 3602) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9836) [M::mem_pestat] mean and std.dev: (2365.41, 2474.92) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12953) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 301, 442) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 900) [M::mem_pestat] mean and std.dev: (305.75, 149.99) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1129) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (309, 1156, 3469) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9789) [M::mem_pestat] mean and std.dev: (2248.09, 2545.35) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12949) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (490, 1323, 3448) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9364) [M::mem_pestat] mean and std.dev: (2240.05, 2336.46) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12322) [M::mem_process_seqs] Processed 1333334 reads in 449.420 CPU sec, 28.585 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12443, 75290, 12665, 12485) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (479, 1334, 3579) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9779) [M::mem_pestat] mean and std.dev: (2349.16, 2460.14) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12879) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 303, 445) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 909) [M::mem_pestat] mean and std.dev: (307.78, 151.27) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1141) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (309, 1115, 3343) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9411) [M::mem_pestat] mean and std.dev: (2109.36, 2392.39) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12445) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (492, 1349, 3532) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9612) [M::mem_pestat] mean and std.dev: (2326.46, 2421.51) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12652) [M::mem_process_seqs] Processed 1333334 reads in 447.994 CPU sec, 28.534 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12327, 74828, 12771, 12231) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (482, 1332, 3616) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9884) [M::mem_pestat] mean and std.dev: (2396.66, 2514.49) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13018) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 301, 441) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 899) [M::mem_pestat] mean and std.dev: (304.50, 149.26) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1128) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (302, 1117, 3321) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9359) [M::mem_pestat] mean and std.dev: (2094.02, 2378.97) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12378) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (487, 1344, 3564) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9718) [M::mem_pestat] mean and std.dev: (2359.03, 2479.35) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12795) [M::mem_process_seqs] Processed 1333334 reads in 452.451 CPU sec, 28.726 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12507, 75582, 12771, 12461) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (488, 1353, 3617) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9875) [M::mem_pestat] mean and std.dev: (2408.63, 2523.13) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13004) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (214, 304, 444) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 904) [M::mem_pestat] mean and std.dev: (307.09, 149.76) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1134) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (304, 1125, 3332) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9388) [M::mem_pestat] mean and std.dev: (2119.02, 2414.23) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12416) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (505, 1355, 3631) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9883) [M::mem_pestat] mean and std.dev: (2417.14, 2527.40) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13009) [M::mem_process_seqs] Processed 1333334 reads in 452.055 CPU sec, 28.669 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12464, 77101, 12723, 12432) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (487, 1306, 3542) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9652) [M::mem_pestat] mean and std.dev: (2330.08, 2448.11) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12707) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 298, 438) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 894) [M::mem_pestat] mean and std.dev: (302.33, 148.65) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1122) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (336, 1187, 3503) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9837) [M::mem_pestat] mean and std.dev: (2252.88, 2531.15) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13004) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (504, 1397, 3615) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9837) [M::mem_pestat] mean and std.dev: (2424.03, 2506.01) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12948) [M::mem_process_seqs] Processed 1333334 reads in 451.298 CPU sec, 28.715 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12655, 78121, 12700, 12701) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (483, 1327, 3563) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9723) [M::mem_pestat] mean and std.dev: (2366.61, 2483.27) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12803) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 299, 436) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 888) [M::mem_pestat] mean and std.dev: (302.21, 148.67) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1114) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (332, 1114, 3244) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9068) [M::mem_pestat] mean and std.dev: (2031.57, 2295.44) [M::mem_pestat] low and high boundaries for proper pairs: (1, 11980) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (488, 1345, 3553) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9683) [M::mem_pestat] mean and std.dev: (2339.40, 2435.84) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12748) [M::mem_process_seqs] Processed 1333334 reads in 444.779 CPU sec, 28.338 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12671, 77406, 12616, 12674) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (478, 1336, 3572) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9760) [M::mem_pestat] mean and std.dev: (2347.80, 2455.24) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12854) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 299, 434) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 882) [M::mem_pestat] mean and std.dev: (301.50, 147.50) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1106) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (314, 1164, 3499) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9869) [M::mem_pestat] mean and std.dev: (2253.12, 2546.83) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13054) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (477, 1293, 3506) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9564) [M::mem_pestat] mean and std.dev: (2296.47, 2423.06) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12593) [M::mem_process_seqs] Processed 1333334 reads in 447.597 CPU sec, 28.399 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12807, 77218, 12572, 12575) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (485, 1329, 3548) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9674) [M::mem_pestat] mean and std.dev: (2339.05, 2448.31) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12737) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 298, 434) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 880) [M::mem_pestat] mean and std.dev: (301.49, 146.54) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1103) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (321, 1180, 3555) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10023) [M::mem_pestat] mean and std.dev: (2299.84, 2600.93) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13257) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (487, 1345, 3463) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9415) [M::mem_pestat] mean and std.dev: (2255.61, 2337.62) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12391) [M::mem_process_seqs] Processed 1333334 reads in 448.368 CPU sec, 28.540 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12789, 76705, 12771, 12482) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (495, 1344, 3612) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9846) [M::mem_pestat] mean and std.dev: (2392.16, 2497.34) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12963) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 300, 438) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 892) [M::mem_pestat] mean and std.dev: (303.11, 148.32) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1119) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (310, 1127, 3410) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9610) [M::mem_pestat] mean and std.dev: (2163.50, 2454.84) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12710) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (483, 1314, 3528) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9618) [M::mem_pestat] mean and std.dev: (2322.57, 2431.74) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12663) [M::mem_process_seqs] Processed 1333334 reads in 447.616 CPU sec, 28.447 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12538, 76965, 12714, 12514) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (481, 1325, 3544) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9670) [M::mem_pestat] mean and std.dev: (2321.02, 2425.08) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12733) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (209, 299, 434) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 884) [M::mem_pestat] mean and std.dev: (301.65, 147.51) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1109) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (327, 1204, 3542) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9972) [M::mem_pestat] mean and std.dev: (2300.21, 2572.39) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13187) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (495, 1336, 3537) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9621) [M::mem_pestat] mean and std.dev: (2333.57, 2443.68) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12663) [M::mem_process_seqs] Processed 1333334 reads in 445.345 CPU sec, 28.305 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12518, 75945, 12620, 12373) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (473, 1298, 3485) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9509) [M::mem_pestat] mean and std.dev: (2255.31, 2364.39) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12521) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (210, 297, 433) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 879) [M::mem_pestat] mean and std.dev: (301.05, 146.65) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1102) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (313, 1208, 3498) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9868) [M::mem_pestat] mean and std.dev: (2263.78, 2537.03) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13053) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (492, 1315, 3581) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9759) [M::mem_pestat] mean and std.dev: (2346.37, 2463.80) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12848) [M::mem_process_seqs] Processed 1333334 reads in 453.572 CPU sec, 28.789 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12458, 75989, 12682, 12560) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (495, 1349, 3628) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9894) [M::mem_pestat] mean and std.dev: (2404.61, 2508.16) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13027) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 300, 440) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 896) [M::mem_pestat] mean and std.dev: (304.73, 149.75) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1124) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (321, 1163, 3446) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9696) [M::mem_pestat] mean and std.dev: (2222.16, 2501.10) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12821) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (491, 1333, 3590) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9788) [M::mem_pestat] mean and std.dev: (2350.54, 2457.49) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12887) [M::mem_process_seqs] Processed 1333334 reads in 450.725 CPU sec, 28.776 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12383, 75733, 12987, 12426) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (485, 1331, 3640) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9950) [M::mem_pestat] mean and std.dev: (2410.54, 2541.85) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13105) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (213, 303, 441) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 897) [M::mem_pestat] mean and std.dev: (305.95, 149.84) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1125) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (289, 1120, 3370) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9532) [M::mem_pestat] mean and std.dev: (2143.27, 2447.26) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12613) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (465, 1313, 3565) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9765) [M::mem_pestat] mean and std.dev: (2340.76, 2476.77) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12865) [M::mem_process_seqs] Processed 1333334 reads in 449.143 CPU sec, 28.561 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12292, 76165, 12929, 12329) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (495, 1350, 3583) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9759) [M::mem_pestat] mean and std.dev: (2373.45, 2478.54) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12847) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 300, 438) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 892) [M::mem_pestat] mean and std.dev: (303.43, 148.91) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1119) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (310, 1118, 3388) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9544) [M::mem_pestat] mean and std.dev: (2153.49, 2453.41) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12622) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (498, 1335, 3555) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9669) [M::mem_pestat] mean and std.dev: (2353.86, 2463.82) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12726) [M::mem_process_seqs] Processed 1333334 reads in 449.777 CPU sec, 28.705 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12454, 75871, 12707, 12527) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (487, 1344, 3565) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9721) [M::mem_pestat] mean and std.dev: (2367.14, 2472.83) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12799) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 302, 439) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 893) [M::mem_pestat] mean and std.dev: (305.32, 149.40) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1120) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (308, 1164, 3386) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9542) [M::mem_pestat] mean and std.dev: (2158.96, 2438.59) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12620) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (494, 1356, 3593) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9791) [M::mem_pestat] mean and std.dev: (2384.61, 2479.80) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12890) [M::mem_process_seqs] Processed 1333334 reads in 449.340 CPU sec, 28.650 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12370, 75476, 12524, 12408) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (477, 1295, 3513) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9585) [M::mem_pestat] mean and std.dev: (2304.61, 2426.60) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12621) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 301, 440) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 896) [M::mem_pestat] mean and std.dev: (304.41, 149.02) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1124) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (322, 1168, 3495) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9841) [M::mem_pestat] mean and std.dev: (2261.06, 2556.30) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13014) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (489, 1341, 3559) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9699) [M::mem_pestat] mean and std.dev: (2346.40, 2442.66) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12769) [M::mem_process_seqs] Processed 1333334 reads in 454.789 CPU sec, 28.977 real sec [M::process] read 1333334 sequences (200000100 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12345, 75602, 12795, 12564) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (476, 1318, 3581) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9791) [M::mem_pestat] mean and std.dev: (2357.17, 2488.68) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12896) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (212, 301, 441) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 899) [M::mem_pestat] mean and std.dev: (305.22, 150.00) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1128) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (312, 1146, 3374) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9498) [M::mem_pestat] mean and std.dev: (2144.96, 2424.17) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12560) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (490, 1358, 3675) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10045) [M::mem_pestat] mean and std.dev: (2457.56, 2586.27) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13230) [M::mem_process_seqs] Processed 1333334 reads in 451.354 CPU sec, 28.686 real sec [M::process] read 1000916 sequences (150137400 bp)... [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (12728, 77914, 12750, 12452) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (480, 1327, 3609) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9867) [M::mem_pestat] mean and std.dev: (2383.03, 2504.29) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12996) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (209, 298, 435) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 887) [M::mem_pestat] mean and std.dev: (301.67, 148.86) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1113) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (319, 1185, 3385) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9517) [M::mem_pestat] mean and std.dev: (2169.54, 2430.72) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12583) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (477, 1323, 3669) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 10053) [M::mem_pestat] mean and std.dev: (2417.06, 2554.33) [M::mem_pestat] low and high boundaries for proper pairs: (1, 13245) [M::mem_process_seqs] Processed 1333334 reads in 442.180 CPU sec, 28.105 real sec [M::mem_pestat] # candidate unique pairs for (FF, FR, RF, RR): (9470, 58277, 9304, 9379) [M::mem_pestat] analyzing insert size distribution for orientation FF... [M::mem_pestat] (25, 50, 75) percentile: (493, 1368, 3583) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9763) [M::mem_pestat] mean and std.dev: (2369.43, 2476.87) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12853) [M::mem_pestat] analyzing insert size distribution for orientation FR... [M::mem_pestat] (25, 50, 75) percentile: (211, 300, 439) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 895) [M::mem_pestat] mean and std.dev: (303.91, 150.39) [M::mem_pestat] low and high boundaries for proper pairs: (1, 1123) [M::mem_pestat] analyzing insert size distribution for orientation RF... [M::mem_pestat] (25, 50, 75) percentile: (330, 1153, 3400) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9540) [M::mem_pestat] mean and std.dev: (2153.89, 2403.52) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12610) [M::mem_pestat] analyzing insert size distribution for orientation RR... [M::mem_pestat] (25, 50, 75) percentile: (493, 1293, 3524) [M::mem_pestat] low and high boundaries for computing mean and std.dev: (1, 9586) [M::mem_pestat] mean and std.dev: (2300.20, 2404.29) [M::mem_pestat] low and high boundaries for proper pairs: (1, 12617) [M::mem_process_seqs] Processed 1000916 reads in 325.662 CPU sec, 20.723 real sec [main] Version: 0.7.17-r1188 [main] CMD: bwa mem -SP5M -t 20 /oak/stanford/groups/akundaje/marinovg/genomes/Chlorophyta/Zygnema_circumcarinatum_SAG_698-1b/bwa-indexes/Zygnema_circumcarinatum_SAG_698-1b.fa /oak/stanford/groups/akundaje/marinovg/papers/2024_ToL_Hi-C/2023-07-09/09-Zygnema/juicer-Zygnema_circumcarinatum_SAG_698-1b-Hi-C/splits/Zygnema_circumcarinatum_SAG_698_R1.fastq.gz /oak/stanford/groups/akundaje/marinovg/papers/2024_ToL_Hi-C/2023-07-09/09-Zygnema/juicer-Zygnema_circumcarinatum_SAG_698-1b-Hi-C/splits/Zygnema_circumcarinatum_SAG_698_R2.fastq.gz [main] Real time: 1619.299 sec; CPU: 24678.688 sec Picked up _JAVA_OPTIONS: -Xmx16384m Picked up _JAVA_OPTIONS: -Xmx16384m Picked up _JAVA_OPTIONS: -Xmx16384m Picked up _JAVA_OPTIONS: -Xmx16384m