# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA processing	2	5.291867e-86	3.48178389265e-82	2.860611	437	0.1734127	6	3.266381809166666e-45	2.372391	285	893	0.1128266	
GO Biological Process	mRNA metabolic process	3	3.636788e-84	1.5952164430666664e-80	3.177958	371	0.1472222	5	3.3676302256e-45	2.63951	234	659	0.09263658	
GO Biological Process	viral gene expression	6	8.961644e-76	1.9654378899333334e-72	8.656113	131	0.05198413	17	1.4035977684705884e-34	4.623983	79	127	0.03127474	
GO Biological Process	viral transcription	10	6.045464e-69	7.955226077599999e-66	8.557074	120	0.04761905	24	1.7887242533750001e-31	4.670601	71	113	0.02810768	
GO Biological Process	multi-organism metabolic process	12	8.582959e-65	9.411929790083333e-62	6.747139	134	0.0531746	25	3.30652193504e-31	4.146574	82	147	0.03246239	
GO Biological Process	ribonucleoprotein complex biogenesis	13	9.663544e-65	9.781736576615384e-62	3.530084	252	0.1	16	1.2246283535625e-34	2.750719	168	454	0.06650831	
GO Biological Process	translation	16	1.479619e-57	1.2168941513125e-54	3.759211	208	0.08253968	11	4.800400807454545e-41	3.157236	158	372	0.06254949	
GO Biological Process	nuclear-transcribed mRNA catabolic process	17	3.001399e-56	2.3232593788823527e-53	5.236069	144	0.05714286	20	1.830601126e-32	3.716746	99	198	0.0391924	
GO Biological Process	mRNA catabolic process	18	4.106802e-56	3.0023004176666667e-53	4.964987	151	0.05992063	18	8.88875828888889e-34	3.664397	105	213	0.0415677	
GO Biological Process	ncRNA metabolic process	19	4.4769e-56	3.1006066894736844e-53	3.211582	247	0.09801587	31	1.661457886903226e-29	2.424256	181	555	0.07165479	
GO Biological Process	RNA catabolic process	20	1.027193e-54	6.758416343500002e-52	4.534594	161	0.06388889	21	2.1701484425714284e-32	3.423724	111	241	0.04394299	
GO Biological Process	translational initiation	21	5.222437e-53	3.272478499190476e-50	6.19873	117	0.04642857	22	2.3714330353181818e-32	4.262562	82	143	0.03246239	
GO Biological Process	peptide biosynthetic process	22	7.743798e-52	4.6318471764545455e-49	3.41278	211	0.08373016	14	4.873766504857142e-39	3.034078	160	392	0.06334125	
GO Biological Process	posttranscriptional regulation of gene expression	23	9.345691e-50	5.346954255173913e-47	2.749354	275	0.109127	49	4.2027751302040815e-23	2.242059	168	557	0.06650831	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	24	6.439863e-49	3.530923217375e-46	7.077097	97	0.03849206	35	6.850086637142857e-29	4.409698	70	118	0.0277118	
GO Biological Process	cotranslational protein targeting to membrane	26	2.618784e-48	1.3254068713846154e-45	7.810623	89	0.03531746	26	7.850289935769231e-31	4.930377	65	98	0.02573238	
GO Biological Process	ncRNA processing	27	2.828336e-48	1.3784471638518519e-45	3.519223	189	0.075	46	8.24995495173913e-24	2.534145	135	396	0.05344418	
GO Biological Process	rRNA metabolic process	28	4.057469e-46	1.906865520392857e-43	4.275928	144	0.05714286	48	3.1926667360416666e-23	2.927475	102	259	0.04038005	
GO Biological Process	RNA splicing, via transesterification reactions	29	5.60683e-46	2.5441474472413796e-43	3.566217	177	0.0702381	87	1.0880576626091954e-17	2.555263	99	288	0.0391924	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	30	6.466563e-46	2.8364500839e-43	7.871213	84	0.03333333	27	5.685375192222222e-30	5.009527	62	92	0.02454473	
GO Cellular Component	intracellular ribonucleoprotein complex	2	3.293606e-99	2.845675584e-96	3.293092	414	0.1642857	9	2.29876032e-53	2.566107	281	814	0.1112431	
GO Cellular Component	ribonucleoprotein complex	3	4.849862e-99	2.7935205119999996e-96	3.288899	414	0.1642857	8	1.669068288e-53	2.565783	282	817	0.111639	
GO Cellular Component	chromosome	18	9.296554e-62	8.92469184e-60	2.298885	457	0.1813492	18	3.37222944e-35	2.119498	278	975	0.1100554	
GO Cellular Component	ribosomal subunit	19	1.113607e-55	1.0127962610526315e-53	5.857749	129	0.05119048	19	6.909333423157895e-35	3.897561	97	185	0.03840063	
GO Cellular Component	chromosomal part	20	3.221849e-55	2.783677536e-53	2.329602	402	0.1595238	22	2.7718816581818183e-29	2.093941	240	852	0.09501188	
GO Cellular Component	ribosome	21	1.988909e-52	1.636587977142857e-50	4.723249	148	0.05873016	21	2.7333676800000005e-31	3.37027	107	236	0.04235946	
GO Cellular Component	nucleoplasm part	22	1.726342e-49	1.3559631709090909e-47	2.060347	462	0.1833333	23	2.103771631304348e-26	1.905135	275	1073	0.1088678	
GO Cellular Component	spliceosomal complex	24	2.367969e-38	1.70493768e-36	4.125976	124	0.04920635	34	2.625640094117647e-16	2.877481	72	186	0.02850356	
GO Cellular Component	cytosolic ribosome	26	5.111523e-38	3.3971968246153844e-36	5.448033	93	0.03690476	20	1.2035485440000001e-32	4.712303	71	112	0.02810768	
GO Cellular Component	nuclear body	29	4.841379e-36	2.8847941075862066e-34	2.108295	326	0.1293651	31	9.236087535483871e-17	1.886725	183	721	0.07244656	
GO Cellular Component	chromosomal region	30	4.948845e-35	2.8505347199999997e-33	2.894206	179	0.07103175	30	1.82608416e-17	2.358502	112	353	0.04433888	
GO Cellular Component	nuclear chromosome part	32	1.475589e-32	7.9681806e-31	2.328648	241	0.09563492	37	1.1479561686486488e-14	1.995762	138	514	0.05463183	
GO Cellular Component	nuclear chromosome	33	4.734356e-32	2.47908096e-30	2.253607	253	0.1003968	35	3.1126039405714283e-16	2.0138	149	550	0.05898654	
GO Cellular Component	small ribosomal subunit	35	1.343846e-29	6.634759679999999e-28	6.70975	60	0.02380952	28	3.212551337142857e-18	4.439446	43	72	0.01702296	
GO Cellular Component	nuclear speck	36	3.489371e-29	1.67489808e-27	2.424417	200	0.07936508	38	3.1901890357894734e-14	2.172254	109	373	0.04315123	
GO Cellular Component	large ribosomal subunit	37	2.133075e-27	9.962036756756757e-26	5.194671	69	0.02738095	33	1.5120047127272727e-16	3.490509	54	115	0.02137767	
GO Cellular Component	chromatin	39	8.63089e-27	3.824148184615385e-25	2.199478	222	0.08809524	41	1.4865183219512195e-12	1.942497	127	486	0.05027712	
GO Cellular Component	cytosolic part	41	7.984702e-26	3.3652597697560975e-24	3.100233	118	0.0468254	29	4.1476111448275855e-18	2.725614	88	240	0.03483769	
GO Cellular Component	cytosolic large ribosomal subunit	42	4.361698e-25	1.7945271771428573e-23	6.300317	53	0.02103175	27	3.5936352e-20	4.996281	41	61	0.0162312	
GO Cellular Component	nuclear chromatin	43	5.68568e-24	2.284850009302326e-22	2.403689	166	0.06587302	46	2.8328832e-8	1.952468	83	316	0.03285827	
GO Molecular Function	RNA binding	1	1.906766e-136	8.050366052e-133	2.584703	761	0.3019841	1	3.0891162286e-77	2.273614	501	1638	0.1983373	
GO Molecular Function	structural constituent of ribosome	5	3.151261e-46	2.6609247883999998e-43	5.542252	112	0.04444444	5	2.7241855476e-31	3.99206	87	162	0.03444181	
GO Molecular Function	ribonucleoprotein complex binding	8	4.888649e-28	2.57998450975e-25	4.757983	77	0.03055556	15	3.822227264e-7	2.650201	41	115	0.0162312	
GO Molecular Function	rRNA binding	10	6.473704e-23	2.7331978288e-20	8.008999	40	0.01587302	18	0.00001521110134888889	3.097288	25	60	0.00989707	
GO Molecular Function	mRNA binding	11	1.91817e-20	7.362285218181817e-18	2.609495	121	0.04801587	10	2.1744562378e-9	2.426477	63	193	0.02494062	
GO Molecular Function	ATP-dependent helicase activity	13	1.72753e-16	5.610485892307693e-14	3.533595	61	0.02420635	11	2.0620063767272727e-8	2.988723	39	97	0.01543943	
GO Molecular Function	helicase activity	14	5.16871e-16	1.5587352585714285e-13	2.75086	85	0.03373016	9	1.0545392604444445e-9	2.676057	54	150	0.02137767	
GO Molecular Function	DNA helicase activity	16	4.289293e-14	1.1318371903749999e-11	4.577589	38	0.01507937	17	0.000003509609522352941	3.48919	23	49	0.009105305	
GO Molecular Function	RNA-dependent ATPase activity	17	7.557465e-13	1.8769186605882353e-10	3.67076	44	0.01746032	24	0.000049035803291666665	2.842217	26	68	0.01029295	
GO Molecular Function	ATP-dependent RNA helicase activity	18	1.502214e-12	3.523526393333333e-10	3.659938	43	0.01706349	28	0.00012163426690714287	2.773691	25	67	0.00989707	
GO Molecular Function	RNA helicase activity	20	2.072852e-12	4.375790572e-10	3.622943	43	0.01706349	30	0.00015672106220000003	2.732901	25	68	0.00989707	
GO Molecular Function	U1 snRNP binding	24	2.076472e-11	3.6528603266666666e-9	32.4164	9	0.003571429	48	0.0038621017670833336	7.433492	5	5	0.001979414	
GO Molecular Function	snRNP binding	25	3.677323e-11	6.2102630824e-9	23.43921	10	0.003968254	47	0.0032812234178723407	6.371564	6	7	0.002375297	
GO Molecular Function	snRNA binding	26	3.761147e-11	6.107524090000001e-9	6.18289	22	0.008730159	88	0.044677894872727275	2.543037	13	38	0.005146477	
GO Molecular Function	ATP-dependent DNA helicase activity	27	7.676956e-11	1.2004484530370371e-8	4.453645	29	0.01150794	19	0.00002007594331578947	3.822939	18	35	0.007125891	
GO Molecular Function	DNA-dependent ATPase activity	33	6.867805e-10	8.786628093939395e-8	2.662137	52	0.02063492	16	4.1043117500000003e-7	2.991527	33	82	0.01306413	
GO Molecular Function	RNA polymerase core enzyme binding	35	1.087715e-9	1.3120950657142857e-7	4.079726	28	0.01111111	27	0.00009310718742962963	3.610553	17	35	0.006730008	
GO Molecular Function	translation initiation factor activity	43	1.939097e-9	1.9039226823255813e-7	3.854521	29	0.01150794	42	0.0017136796428571428	2.76934	19	51	0.007521774	
GO Molecular Function	aminoacyl-tRNA ligase activity	45	2.402727e-9	2.254291865333333e-7	4.056627	27	0.01071429	26	0.00006133495885384615	3.303774	20	45	0.007917656	
GO Molecular Function	protein transporter activity	46	3.13843e-9	2.8805329260869563e-7	2.763289	45	0.01785714	32	0.00021327076768750002	2.400398	31	96	0.01227237	
Mouse Phenotype Single KO	embryonic lethality prior to organogenesis	1	7.686183e-30	7.0382377731e-26	2.044511	290	0.1150794	5	1.0492645514199998e-12	1.814311	175	717	0.06927949	
Mouse Phenotype Single KO	embryonic growth arrest	7	4.008991e-15	5.244332941e-12	2.0784	138	0.0547619	25	0.000337841764404	1.822772	64	261	0.0253365	
Mouse Phenotype Single KO	chromosomal instability	13	1.013183e-10	7.136705177692308e-8	2.817238	52	0.02063492	16	0.000006804309159374999	2.74716	34	92	0.01346002	
Mouse Phenotype Single KO	abnormal chromosome stability	14	1.177412e-10	7.701115488571429e-8	2.804914	52	0.02063492	19	0.000010750433667368421	2.68871	34	94	0.01346002	
Mouse Phenotype Single KO	abnormal DNA replication	35	8.93816e-8	0.00002338478032	4.818315	18	0.007142857	38	0.01747915871973684	3.555148	11	23	0.004354711	
Mouse Phenotype Single KO	increased sensitivity to induced cell death	48	5.644837e-7	0.00010768702585208335	2.110808	54	0.02142857	39	0.04336515709230769	1.832916	36	146	0.01425178	
Mouse Phenotype	increased cellular sensitivity to ionizing radiation	18	1.284256e-8	0.0000068215397866666665	2.869236	39	0.01547619	38	0.027880957902631582	2.202516	24	81	0.009501188	
Mouse Phenotype	abnormal DNA replication	23	5.860181e-8	0.000024360517626521738	4.271526	21	0.008333333	24	0.000874464596625	3.854403	14	27	0.005542359	
Mouse Phenotype	increased sensitivity to induced cell death	27	1.045696e-7	0.000037029257244444436	2.057075	65	0.02579365	41	0.03521750042926829	1.746667	43	183	0.01702296	
Mouse Phenotype	chromosomal instability	31	4.158081e-7	0.00012824326593870966	2.0994	56	0.02222222	15	0.000036284402936	2.456284	38	115	0.01504355	
Mouse Phenotype	abnormal chromosome stability	33	4.560478e-7	0.00013212948532727274	2.093036	56	0.02222222	16	0.00005689938734625	2.414296	38	117	0.01504355	
Mouse Phenotype	decreased fibroblast proliferation	35	7.008311e-7	0.00019144703277428573	2.112212	53	0.02103175	36	0.02140670718333333	1.944144	34	130	0.01346002