# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	3	1.698115e-52	7.448498428333334e-49	2.060169	534	0.06287531	17	3.823438788941176e-36	1.731986	354	555	0.05119306	
GO Biological Process	ribonucleoprotein complex biogenesis	8	3.465463e-48	5.700253452125e-45	2.053293	494	0.05816555	20	1.43785432225e-33	1.782356	298	454	0.04309472	
GO Biological Process	ncRNA processing	10	2.326091e-45	3.0609031469e-42	2.19891	398	0.04686212	22	2.2025875137727273e-32	1.823982	266	396	0.0384671	
GO Biological Process	rRNA processing	16	2.719481e-42	2.2366031549375e-39	2.537625	279	0.03285058	35	5.165775994e-26	1.928797	179	252	0.02588576	
GO Biological Process	rRNA metabolic process	18	5.757391e-42	4.2089726760555554e-39	2.502221	284	0.0334393	34	3.791648967117647e-26	1.918604	183	259	0.02646421	
GO Biological Process	translation	19	3.7363e-41	2.5876827210526313e-38	2.112852	394	0.04639115	19	2.3193949513157895e-34	1.875963	257	372	0.03716558	
GO Biological Process	ribosome biogenesis	20	3.563309e-40	2.34447915655e-37	2.221529	344	0.04050394	31	2.1219464798064518e-27	1.841093	219	323	0.03167028	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	22	4.449421e-36	2.6613604972272727e-33	3.333831	154	0.01813258	70	7.599427771999999e-17	2.094081	91	118	0.0131598	
GO Biological Process	nuclear-transcribed mRNA catabolic process	25	2.358435e-35	1.2413858466e-32	2.524632	234	0.0275521	52	6.120681098076923e-20	1.919981	140	198	0.02024584	
GO Biological Process	protein targeting to ER	26	1.499479e-34	7.589093908076923e-32	3.460162	140	0.01648416	71	8.589698494084507e-17	2.177698	81	101	0.01171367	
GO Biological Process	mRNA catabolic process	28	1.905356e-33	8.954492715714286e-31	2.390268	245	0.02884729	54	2.358579683e-19	1.874009	147	213	0.02125813	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	32	1.171004e-31	4.8153880112500005e-29	2.864643	168	0.019781	551	0.02678135919782214	1.393746	58	113	0.008387563	
GO Biological Process	viral gene expression	33	1.701883e-31	6.786387393030303e-29	3.019338	154	0.01813258	65	1.8693381853076923e-17	2.073968	97	127	0.01402748	
GO Biological Process	cotranslational protein targeting to membrane	34	2.592996e-31	1.0035657165882352e-28	3.385154	130	0.01530672	81	7.911444232592592e-16	2.161238	78	98	0.01127983	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	35	3.427862e-31	1.2887781730857142e-28	3.475456	125	0.014718	76	2.7255976982894737e-16	2.213642	75	92	0.01084599	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	38	1.92521e-30	6.66679957631579e-28	3.097853	143	0.0168374	74	1.638495018891892e-16	2.14646	83	105	0.01200289	
GO Biological Process	RNA catabolic process	39	2.633941e-30	8.887187081794871e-28	2.197899	263	0.03096668	57	4.998254536491228e-19	1.814023	161	241	0.02328272	
GO Biological Process	endoplasmic reticulum unfolded protein response	40	7.145831e-30	2.350799753225e-27	2.853823	159	0.0187213	252	0.00007817385928571429	1.595894	67	114	0.009689082	
GO Biological Process	mitochondrial transport	41	7.352292e-30	2.3597270836097563e-27	2.129325	278	0.03273284	125	8.984891509600002e-11	1.613335	142	239	0.02053507	
GO Biological Process	regulation of DNA-templated transcription in response to stress	42	2.612094e-29	8.183939272857142e-27	2.653056	176	0.02072295	435	0.007145076845057471	1.437565	63	119	0.009110629	
GO Cellular Component	intracellular ribonucleoprotein complex	13	1.970536e-82	2.6192970830769226e-80	2.029745	860	0.1012599	20	1.021533984e-40	1.627906	488	814	0.07057122	
GO Cellular Component	ribonucleoprotein complex	14	3.540227e-82	4.369651611428572e-80	2.02716	860	0.1012599	19	6.125951898947368e-41	1.628576	490	817	0.07086045	
GO Cellular Component	ribosomal subunit	24	2.170568e-39	1.5628089599999998e-37	2.856382	212	0.02496173	29	1.377286907586207e-20	1.952153	133	185	0.01923355	
GO Cellular Component	ribosome	26	2.067504e-37	1.374094966153846e-35	2.462022	260	0.03061345	28	4.648430468571428e-21	1.852456	161	236	0.02328272	
GO Cellular Component	large ribosomal subunit	36	9.917652e-30	4.76047296e-28	3.105011	139	0.01636642	43	2.1507089860465116e-12	1.936199	82	115	0.01185828	
GO Cellular Component	spliceosomal complex	37	1.301674e-29	6.079169383783784e-28	2.300384	233	0.02743436	33	4.468990254545455e-16	1.839465	126	186	0.01822126	
GO Cellular Component	catalytic step 2 spliceosome	39	9.815227e-25	4.3489005784615386e-23	2.815561	133	0.01565996	46	1.080259575652174e-10	1.951695	69	96	0.009978308	
GO Cellular Component	cytosolic ribosome	40	7.49177e-19	3.23644464e-17	2.363933	136	0.01601319	41	3.932871945365854e-14	2.012306	83	112	0.01200289	
GO Cellular Component	mitochondrial ribosome	41	9.295009e-19	3.917506232195122e-17	3.123825	84	0.009890498	77	0.00003379815397402597	1.693133	53	85	0.007664497	
GO Cellular Component	spliceosomal snRNP complex	45	1.286548e-17	4.940344320000001e-16	3.191751	76	0.008948546	54	3.4635904e-7	1.970856	45	62	0.006507592	
GO Cellular Component	cytosolic large ribosomal subunit	46	1.901603e-17	7.143413008695651e-16	2.96282	84	0.009890498	45	2.18788416e-11	2.225739	50	61	0.007230658	
GO Cellular Component	proteasome complex	47	2.3152e-17	8.512054468085107e-16	2.866581	88	0.01036147	87	0.00017062013793103448	1.717092	43	68	0.006218366	
GO Cellular Component	endopeptidase complex	48	2.392332e-17	8.6123952e-16	2.864962	88	0.01036147	91	0.00027905547956043954	1.692207	43	69	0.006218366	
GO Cellular Component	peptidase complex	49	2.407445e-17	8.4899284897959175e-16	2.554846	107	0.01259861	67	0.000022201932035820897	1.697126	55	88	0.007953724	
GO Cellular Component	small nuclear ribonucleoprotein complex	53	6.277954e-15	2.0468499079245282e-13	2.763292	79	0.009301778	65	0.0000033464926523076924	1.849621	47	69	0.006796819	
GO Cellular Component	small ribosomal subunit	59	8.949129e-14	2.621033035932203e-12	2.62133	79	0.009301778	51	3.5415936e-8	1.961123	52	72	0.007519884	
GO Cellular Component	mitochondrial large ribosomal subunit	60	2.176998e-13	6.26975424e-12	3.316078	53	0.006240433	149	0.013155484348993288	1.597295	30	51	0.004338395	
GO Cellular Component	inner mitochondrial membrane protein complex	62	3.540861e-13	9.86872227096774e-12	2.019093	130	0.01530672	55	4.0268086690909094e-7	1.645097	83	137	0.01200289	
GO Cellular Component	proton-transporting ATP synthase complex	65	4.710608e-12	1.2522970190769232e-10	4.318185	34	0.004003297	174	0.028465473103448276	1.810268	16	24	0.002313811	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	66	8.94834e-12	2.342838109090909e-10	4.329909	33	0.003885553	192	0.04769767799999999	1.770914	15	23	0.002169197	
GO Molecular Function	structural constituent of ribosome	3	2.338411e-38	3.290923747333334e-35	2.921869	199	0.02343106	7	2.9936181471428574e-22	2.078455	124	162	0.01793203	
GO Molecular Function	rRNA binding	6	8.434192e-29	5.934859770666667e-26	4.75278	80	0.009419522	18	0.0000021881096697777775	1.991294	44	60	0.006362979	
GO Molecular Function	unfolded protein binding	10	3.082331e-18	1.3013601482e-15	2.620961	108	0.01271635	49	0.0009510873551020409	1.562637	61	106	0.008821403	
GO Molecular Function	ribonucleoprotein complex binding	11	5.573479e-18	2.1392025761818182e-15	2.365164	129	0.01518898	22	0.00000916389513909091	1.676465	71	115	0.01026753	
GO Molecular Function	snRNA binding	35	1.461754e-10	1.763292968e-8	3.335556	40	0.004709761	75	0.015197584381333333	1.786448	25	38	0.003615329	
GO Molecular Function	ribonuclease activity	40	5.745215e-10	6.0640744325e-8	2.002869	96	0.01130343	24	0.000009303175240833333	1.727983	63	99	0.009110629	
GO Molecular Function	endoribonuclease activity	91	8.134841e-7	0.00003774208648571429	2.076721	55	0.006475921	45	0.00021890488302222223	1.842594	38	56	0.0054953	
GO Molecular Function	aminoacyl-tRNA editing activity	110	0.000002864067	0.00010992809885454546	3.610842	19	0.002237136	44	0.00021833631609090905	2.715401	13	13	0.001879971	
GO Molecular Function	ubiquitin-specific protease binding	119	0.000004663016	0.0001654391054789916	3.238324	21	0.002472625	83	0.018579694359036142	2.206264	13	16	0.001879971	
GO Molecular Function	L-serine transmembrane transporter activity	165	0.000045648	0.001168035490909091	3.674834	14	0.001648416	91	0.03853516366813187	2.443861	9	10	0.001301518	
GO Molecular Function	RNA polymerase III regulatory region DNA binding	208	0.0001660738	0.003370978767307693	3.92034	11	0.001295184	92	0.0420783519	2.715401	7	7	0.001012292	
GO Molecular Function	cAMP response element binding	307	0.001209277	0.016630513009771985	2.104488	22	0.002590369	88	0.027685899336363638	2.297647	11	13	0.001590745	
Human Phenotype	Increased serum lactate	10	1.900424e-11	1.2681529352e-8	2.132294	97	0.01142117	45	0.00029977948317777775	1.629241	60	100	0.00867679	
Human Phenotype	Lipid accumulation in hepatocytes	13	1.986141e-10	1.0195014533076923e-7	2.132225	87	0.01024373	70	0.006135500336142857	1.621698	43	72	0.006218366	
Human Phenotype	Hepatic steatosis	26	3.620415e-9	9.291934344230769e-7	2.103995	77	0.00906629	94	0.024483670035106382	1.602532	36	61	0.005206074	
Human Phenotype	Abnormality of the mitochondrion	40	6.104581e-8	0.00001018396725325	2.001912	73	0.008595314	42	0.00024739686745238096	1.759274	46	71	0.006652205	
Human Phenotype	CNS hypomyelination	44	1.647732e-7	0.000024989353718181817	2.772508	35	0.004121041	44	0.00025175120938636364	2.172321	24	30	0.003470716	
Human Phenotype	Increased CSF lactate	85	0.000004762758	0.00037390451922352934	2.07821	47	0.005533969	87	0.017428395667816093	1.638604	35	58	0.005061461	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	183	0.0003284997	0.011978571027868853	2.514828	19	0.002237136	111	0.048968980883783784	2.172321	12	15	0.001735358	
Human Phenotype	Inverted nipples	205	0.0005532741	0.018009746679512193	2.239298	22	0.002590369	89	0.018436216884269663	2.327487	12	14	0.001735358	
Human Phenotype	Global brain atrophy	206	0.0005722908	0.018538332565048544	2.338345	20	0.00235488	77	0.00898882565194805	2.353348	13	15	0.001879971	
Human Phenotype	Reticulocytopenia	303	0.002053888	0.04523298555775577	2.254969	17	0.002001648	92	0.02426371705978261	2.468547	10	11	0.001446132