# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	23	1.086297e-27	6.215035749130435e-25	2.287247	220	0.02372479	266	0.00017396173265037592	1.496239	84	155	0.01235112	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	25	1.155439e-26	6.0817687203999994e-24	2.592449	166	0.01790143	583	0.01586152906072041	1.417108	58	113	0.008528158	
GO Biological Process	rRNA processing	28	2.57885e-26	1.2119673982142857e-23	2.099252	252	0.02717567	206	0.000012584897103883496	1.435239	131	252	0.01926187	
GO Biological Process	rRNA metabolic process	29	4.349648e-26	1.9736902769655172e-23	2.073869	257	0.02771487	208	0.000012984048564423079	1.428428	134	259	0.01970298	
GO Biological Process	endoplasmic reticulum unfolded protein response	32	4.096364e-25	1.6845016836249999e-22	2.580895	157	0.01693087	300	0.0004820431198	1.549989	64	114	0.009410381	
GO Biological Process	IRE1-mediated unfolded protein response	36	8.42438e-25	3.079344900555556e-22	3.559877	95	0.0102448	426	0.004815644163849765	1.666071	35	58	0.005146302	
GO Biological Process	nuclear-transcribed mRNA catabolic process	37	1.270564e-24	4.518743696216216e-22	2.16405	219	0.02361695	256	0.000094719098828125	1.450179	104	198	0.01529187	
GO Biological Process	cellular response to topologically incorrect protein	39	5.487313e-24	1.851475686333333e-21	2.354461	178	0.01919551	373	0.0021176147209115283	1.449978	73	139	0.01073372	
GO Biological Process	regulation of DNA-templated transcription in response to stress	40	1.323165e-23	4.35288205875e-21	2.374669	172	0.01854847	550	0.012974924730363636	1.41526	61	119	0.008969269	
GO Biological Process	response to topologically incorrect protein	42	1.929432e-23	6.045094211428572e-21	2.131972	215	0.02318559	284	0.00035779649975	1.441812	94	180	0.0138215	
GO Biological Process	cellular response to epidermal growth factor stimulus	45	2.397141e-23	7.009772982e-21	2.920383	118	0.01272512	565	0.015322903224424778	1.743737	24	38	0.003528893	
GO Biological Process	response to epidermal growth factor	50	1.366981e-22	3.5976205958000005e-20	2.797897	122	0.01315648	561	0.014540195380213903	1.709139	26	42	0.003822967	
GO Biological Process	mRNA catabolic process	54	2.198822e-22	5.3582034625925924e-20	2.037306	228	0.02458751	264	0.00013553356289015153	1.425826	110	213	0.01617409	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	60	1.394943e-21	3.0593424895e-19	2.44104	148	0.01596031	651	0.02303617369892473	1.439202	49	94	0.007204823	
GO Biological Process	translational elongation	62	3.020719e-21	6.411232471129032e-19	2.593929	130	0.0140192	171	0.0000010213246267836258	1.725573	70	112	0.0102926	
GO Biological Process	cellular response to unfolded protein	63	3.886029e-21	8.11686597e-19	2.327844	159	0.01714655	334	0.001123039095718563	1.505955	66	121	0.009704455	
GO Biological Process	mitochondrial translational elongation	64	4.331115e-21	8.905178482031251e-19	2.988976	102	0.01099968	176	0.000001883690662897727	1.818957	56	85	0.008234083	
GO Biological Process	mitochondrial translational termination	65	4.433236e-21	8.974915772923076e-19	2.969055	103	0.01110752	177	0.0000019027096209039548	1.808877	57	87	0.00838112	
GO Biological Process	mitochondrial translation	70	1.775477e-20	3.3376431204285713e-18	2.640883	121	0.01304864	175	0.0000018228267888000003	1.728799	67	107	0.009851492	
GO Biological Process	response to unfolded protein	72	2.947991e-20	5.3878629956944434e-18	2.083265	194	0.02092095	269	0.00020572213148698884	1.483993	86	160	0.0126452	
GO Cellular Component	ribosomal subunit	30	3.417276e-29	1.9683509760000003e-27	2.468035	200	0.02156799	36	7.7124144e-11	1.701322	114	185	0.01676224	
GO Cellular Component	ribosome	31	5.119452e-28	2.853681630967742e-26	2.1682	250	0.02695999	31	3.5000478348387097e-13	1.684628	144	236	0.02117336	
GO Cellular Component	mitochondrial ribosome	36	1.434029e-23	6.8833392e-22	3.337908	98	0.01056832	47	2.6088744714893614e-7	1.851439	57	85	0.00838112	
GO Cellular Component	large ribosomal subunit	37	1.913513e-23	8.936622875675674e-22	2.721077	133	0.01434272	44	2.652256930909091e-9	1.824606	76	115	0.01117483	
GO Cellular Component	mitochondrial large ribosomal subunit	41	2.125353e-21	8.957585326829268e-20	4.011324	70	0.007548798	53	9.166003199999999e-7	2.057154	38	51	0.005587414	
GO Cellular Component	proteasome complex	54	1.015075e-12	3.24824e-11	2.446449	82	0.008842877	107	0.011713432104672898	1.542866	38	68	0.005587414	
GO Cellular Component	endopeptidase complex	55	1.043745e-12	3.2792570181818184e-11	2.445068	82	0.008842877	110	0.016576578327272728	1.520505	38	69	0.005587414	
GO Cellular Component	peptidase complex	57	2.390165e-12	7.245973894736842e-11	2.186865	100	0.010784	104	0.011929071876923077	1.474581	47	88	0.006910748	
GO Cellular Component	PcG protein complex	62	9.651761e-12	2.69003919483871e-10	2.270086	87	0.009382077	115	0.023435316313043478	1.620539	27	46	0.003970004	
GO Cellular Component	small ribosomal subunit	105	5.454422e-8	8.976420205714285e-7	2.066542	68	0.007333118	112	0.02145747085714286	1.495497	39	72	0.005734451	
GO Cellular Component	nucleosome	108	7.334351e-8	0.0000011734961599999997	2.062048	67	0.007225278	140	0.04300852525714286	1.367312	52	105	0.007645934	
GO Cellular Component	cytosolic large ribosomal subunit	120	2.709674e-7	0.00000390193056	2.035201	63	0.006793918	85	0.001776753995294118	1.674655	37	61	0.005440376	
GO Cellular Component	very-low-density lipoprotein particle	144	0.000003899461	0.000046793532	2.715172	28	0.003019519	127	0.03008166349606299	1.932642	14	20	0.002058521	
GO Cellular Component	mitochondrial nucleoid	169	0.0000275126	0.0002813122650887574	2.040406	41	0.004421439	82	0.0012259407687804879	1.840612	28	42	0.004117042	
GO Molecular Function	structural constituent of ribosome	9	1.842961e-22	8.645534824444445e-20	2.313007	172	0.01854847	17	7.929012857647059e-9	1.70427	100	162	0.01470372	
GO Molecular Function	ribonucleoprotein complex binding	20	3.18725e-12	6.728284750000001e-10	2.015087	120	0.0129408	73	0.019034389613698632	1.440479	60	115	0.008822232	
GO Molecular Function	NF-kappaB binding	62	9.566364e-8	0.000006514385291612904	2.552563	42	0.004529279	61	0.01110390844918033	1.972084	20	28	0.002940744	
Human Phenotype	Increased serum lactate	13	4.307575e-17	2.2111113826923076e-14	2.39587	119	0.01283296	12	0.000002460908978	1.794596	65	100	0.009557418	
Human Phenotype	Exercise intolerance	14	7.676341e-17	3.6588731066428576e-14	2.848449	86	0.009274237	17	0.000003585919861235294	1.932642	49	70	0.007204823	
Human Phenotype	Increased serum ferritin	15	1.001782e-16	4.4565941906666665e-14	5.440547	39	0.004205759	329	0.04484221519452888	1.932642	14	20	0.002058521	
Human Phenotype	Abnormal CSF metabolite level	22	4.648541e-15	1.4099870042272728e-12	2.824001	77	0.008303677	77	0.0002581825297922078	1.796788	41	63	0.006028525	
Human Phenotype	Increased CSF lactate	23	6.511082e-14	1.8890630515652174e-11	2.834852	70	0.007548798	86	0.0004172010811395349	1.808877	38	58	0.005587414	
Human Phenotype	Abnormality of mitochondrial metabolism	37	4.580077e-11	8.260230762432431e-9	2.210665	86	0.009274237	94	0.0006452296204148936	1.720572	43	69	0.0063226	
Human Phenotype	Abnormality of the mitochondrion	40	6.230826e-11	1.03945754745e-8	2.185155	87	0.009382077	92	0.000641231707902174	1.710991	44	71	0.006469637	
Human Phenotype	Mitochondrial inheritance	42	8.722018e-11	1.3857625265238094e-8	2.747816	55	0.005931198	236	0.020736647219491526	1.606352	32	55	0.00470519	
Human Phenotype	Atherosclerosis	49	6.640824e-10	9.043718071836734e-8	2.518705	58	0.006254718	326	0.04370360580981595	1.705273	21	34	0.003087781	
Human Phenotype	Increased muscle lipid content	70	1.877597e-8	0.000001789886397285714	3.677192	27	0.002911679	111	0.001454271538018018	2.324983	16	19	0.002352595	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	104	3.506886e-7	0.00002250139449807692	3.560472	23	0.002480319	203	0.012930446321182265	2.14738	14	18	0.002058521	
Human Phenotype	Increased intramyocellular lipid droplets	109	4.606849e-7	0.00002820321410733945	3.392351	24	0.002588159	157	0.00558885851656051	2.273697	14	17	0.002058521	
Human Phenotype	Bronchiolitis	170	0.000003245914	0.00012741167130588235	3.919979	17	0.001833279	333	0.04517989718318318	2.760918	6	6	0.0008822232	
Human Phenotype	Stillbirth	224	0.00001503839	0.0004479963235267857	2.249935	35	0.003774399	186	0.009381513297849461	2.040678	17	23	0.002499632	
Human Phenotype	Increased hepatocellular lipid droplets	242	0.00002412328	0.0006651844935537189	3.209272	18	0.001941119	262	0.029345969259541985	2.300765	10	12	0.001470372	
Human Phenotype	Renal Fanconi syndrome	295	0.00009554078	0.0021611648303050844	2.98319	17	0.001833279	293	0.034829689337883954	2.169292	11	14	0.001617409	
Human Phenotype	Exertional dyspnea	314	0.0001305928	0.002775304950318471	2.495607	22	0.002372479	329	0.04484221519452888	1.932642	14	20	0.002058521	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	354	0.0002325842	0.004384277871751412	2.39194	22	0.002372479	305	0.040063269885245896	2.070688	12	16	0.001764446	
Human Phenotype	Abnormality of the odontoid process	409	0.0005012533	0.008178149806601467	2.168099	24	0.002588159	148	0.004650291962837837	2.133436	17	22	0.002499632	
Human Phenotype	Talipes equinovalgus	418	0.000601821	0.00960753955263158	3.150532	12	0.00129408	333	0.04517989718318318	2.760918	6	6	0.0008822232	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	34	1.523181e-14	4.102284828529412e-12	2.101071	132	0.01423488	132	0.0070140330749999995	1.719062	33	53	0.004852228	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	127	4.623364e-8	0.0000033335546573228346	2.039634	71	0.007656638	79	0.000627548683113924	1.794596	39	60	0.005734451	
Mouse Phenotype Single KO	early cellular replicative senescence	134	9.672332e-8	0.000006609667471940299	2.08495	64	0.006901758	99	0.0016520263943434344	1.805215	34	52	0.004999265	
Mouse Phenotype Single KO	thin hypoglossal nerve	141	1.30714e-7	0.000008488993602836878	3.025935	31	0.003343039	183	0.03423233365081967	2.208734	12	15	0.001764446	
Mouse Phenotype Single KO	absent stapedial artery	365	0.00013688	0.0034340004383561647	2.244561	27	0.002911679	158	0.017489835226582276	2.243245	13	16	0.001911484	
Mouse Phenotype Single KO	abnormal stapedial artery morphology	393	0.0002088406	0.004866039120101782	2.184351	27	0.002911679	192	0.040787333555729166	2.11129	13	17	0.001911484	
Mouse Phenotype	decreased circulating free fatty acid level	22	1.542879e-19	6.705211872272728e-17	2.049748	194	0.02092095	390	0.04610593675384616	1.368858	59	119	0.008675195	
Mouse Phenotype	dry eyes	50	3.697875e-15	7.071076575e-13	3.355185	60	0.006470398	267	0.010806415143820225	2.243245	13	16	0.001911484	
Mouse Phenotype	early cellular replicative senescence	65	3.153854e-13	4.6390766298461535e-11	2.226247	104	0.01121536	81	0.000032055861118518516	1.815398	48	73	0.007057786	
Mouse Phenotype	abnormal cellular replicative senescence	89	1.598203e-11	1.7169009980898876e-9	2.045505	108	0.01164672	100	0.00013900680534	1.709139	52	84	0.007645934	
Mouse Phenotype	thin hypoglossal nerve	194	1.30714e-7	0.000006442044092783504	3.025935	31	0.003343039	318	0.020568876953773584	2.208734	12	15	0.001764446	
Mouse Phenotype	abnormal vitelline vein morphology	207	2.362253e-7	0.000010910870015942028	2.07083	61	0.006578238	360	0.032652859991666665	1.877424	17	25	0.002499632	
Mouse Phenotype	abnormal hypoglossal nerve topology	363	0.00003325854	0.0008759914626446282	2.404305	28	0.003019519	399	0.049267377714285715	1.993996	13	18	0.001911484	
Mouse Phenotype	broad head	543	0.0007357744	0.012955320512707183	2.146845	23	0.002480319	331	0.023574670352265858	2.760918	7	7	0.00102926