# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	25	2.31841e-55	1.2203182876e-52	2.626096	350	0.01813378	317	0.00006910338845741326	1.35931	90	113	0.008180331	
GO Biological Process	endoplasmic reticulum unfolded protein response	31	9.183252e-51	3.8981423570322584e-48	2.590509	328	0.01699394	419	0.0006972291439140811	1.317445	88	114	0.007998546	
GO Biological Process	regulation of DNA-templated transcription in response to stress	34	8.101183e-50	3.1353960910882353e-47	2.421073	365	0.01891094	268	0.000011837571255970149	1.376825	96	119	0.008725686	
GO Biological Process	mRNA catabolic process	46	5.037169e-45	1.440958845021739e-42	2.043473	476	0.02466193	138	1.0911213947826086e-9	1.370159	171	213	0.01554263	
GO Biological Process	cellular response to topologically incorrect protein	47	2.263451e-44	6.33718121468085e-42	2.294136	361	0.01870369	377	0.00031160690012997346	1.301504	106	139	0.009634612	
GO Biological Process	cellular response to unfolded protein	50	6.607937e-44	1.73907685966e-41	2.363396	336	0.01740842	410	0.0005749090071707317	1.311753	93	121	0.008453009	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	2.873605e-43	7.271878499038461e-41	2.079398	438	0.02269312	160	1.3715362520000002e-8	1.361904	158	198	0.01436103	
GO Biological Process	response to topologically incorrect protein	63	2.315989e-41	4.8374760715873016e-39	2.053339	431	0.02233045	358	0.0002194222082178771	1.270536	134	180	0.0121796	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	66	4.279229e-41	8.531874910757576e-39	2.077898	416	0.02155329	591	0.006051387693231811	1.233221	112	155	0.01017997	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	69	2.716121e-40	5.179918295507246e-38	4.182109	131	0.006787213	626	0.008721812526996804	1.564466	22	24	0.001999636	
GO Biological Process	response to unfolded protein	72	6.538184e-40	1.1949439341111112e-37	2.079162	403	0.02087975	384	0.0003359001636276042	1.280017	120	160	0.01090711	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	74	1.425767e-39	2.5353605341891893e-37	3.840939	142	0.007357132	825	0.037759902027878794	1.600022	15	16	0.001363388	
GO Biological Process	cellular response to epidermal growth factor stimulus	83	3.661687e-38	5.8053179798795174e-36	2.699132	227	0.01176105	670	0.013303393510597013	1.437212	32	38	0.002908562	
GO Biological Process	response to epidermal growth factor	94	2.257743e-36	3.160600014574468e-34	2.578269	234	0.01212372	655	0.011322851401221372	1.422241	35	42	0.00318124	
GO Biological Process	liver regeneration	96	8.996941e-36	1.2332369439479167e-33	3.089713	171	0.008859645	519	0.0029456560949903663	1.511639	31	35	0.00281767	
GO Biological Process	multi-organism metabolic process	104	7.353257e-35	9.303991236826924e-33	2.143153	326	0.01689032	186	1.3581191658064517e-7	1.393216	120	147	0.01090711	
GO Biological Process	regulation of hematopoietic stem cell differentiation	107	2.458634e-34	3.0236602622429903e-32	2.495105	234	0.01212372	797	0.03093831147051443	1.242735	75	103	0.006816942	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	108	2.86698e-34	3.4932027611111107e-32	2.509603	231	0.01196829	485	0.002089423190783505	1.356599	62	78	0.005635339	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	133	1.826442e-31	1.8070789682706766e-29	6.906263	63	0.00326408	860	0.042670214963953484	1.70669	11	11	0.0009998182	
GO Biological Process	viral gene expression	135	2.5809e-31	2.5157083777777776e-29	2.251712	261	0.01352262	197	3.3167874031979697e-7	1.411043	105	127	0.009543719	
GO Cellular Component	large ribosomal subunit	59	1.554095e-21	4.5516545084745764e-20	2.074016	211	0.01093208	69	0.00002207187172173913	1.365352	92	115	0.008362116	
GO Cellular Component	mitochondrial ribosome	62	8.474905e-21	2.362038038709677e-19	2.405504	147	0.007616186	78	0.00017424972553846152	1.38543	69	85	0.006271587	
GO Cellular Component	endopeptidase complex	78	5.066096e-17	1.122335113846154e-15	2.148863	150	0.007771618	83	0.000368621956626506	1.409874	57	69	0.005180876	
GO Cellular Component	proteasome complex	88	2.265639e-16	4.448891127272727e-15	2.12141	148	0.007667996	85	0.0005115699275294118	1.405509	56	68	0.005089984	
GO Cellular Component	mitochondrial large ribosomal subunit	94	1.036198e-15	1.9048405787234042e-14	2.587963	94	0.004870214	140	0.028739145599999998	1.33858	40	51	0.003635703	
GO Cellular Component	U1 snRNP	194	1.859207e-8	1.656035925773196e-7	2.440269	51	0.00264235	153	0.043610767058823524	1.527038	17	19	0.001545174	
GO Cellular Component	INO80-type complex	323	0.00009189666	0.0004916329055108359	2.102428	33	0.001709756	148	0.04087774313513514	1.484078	20	23	0.001817851	
GO Molecular Function	unfolded protein binding	12	3.19434e-28	1.12387529e-25	2.327955	218	0.01129475	59	0.00038468924742372877	1.352471	84	106	0.007634975	
GO Molecular Function	rRNA binding	17	2.932355e-22	7.282589888235294e-20	2.927905	112	0.005802808	62	0.0006630550897741936	1.450686	51	60	0.004635521	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	78	2.365049e-11	1.280158574102564e-9	2.209136	89	0.00461116	69	0.002513616650724638	1.588987	27	29	0.002454099	
Human Phenotype	Increased serum lactate	9	4.796771e-22	3.556539209222222e-19	2.079674	215	0.01113932	63	0.00016182363946031747	1.382419	81	100	0.007362298	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	153	9.617704e-16	5.756164413594771e-14	2.764796	84	0.004352106	247	0.037985942319838054	1.551536	20	22	0.001817851	
Mouse Phenotype Single KO	increased respiratory quotient	188	4.748042e-14	2.3126500315957446e-12	2.016767	141	0.007305321	213	0.02286476245821596	1.393216	40	49	0.003635703	
Mouse Phenotype Single KO	decreased creatinine clearance	318	5.125705e-10	1.4759773800314464e-8	2.642343	54	0.002797782	269	0.049903811791821566	1.606296	16	17	0.001454281	
Mouse Phenotype	spontaneous skin ulceration	103	2.574385e-22	2.3896791247572815e-20	2.476298	150	0.007771618	389	0.02847772115167095	1.408019	33	40	0.002999455	
Mouse Phenotype	early cellular replicative senescence	112	2.055465e-21	1.7546697200892855e-19	2.098025	204	0.0105694	174	0.000800940905	1.402759	60	73	0.005453554	
Mouse Phenotype	absent segment of posterior cerebral artery	197	9.617704e-16	4.667759794111675e-14	2.764796	84	0.004352106	376	0.026054462417553194	1.551536	20	22	0.001817851	
Mouse Phenotype	increased liver adenoma incidence	249	8.139562e-14	3.125395673975904e-12	2.510577	86	0.004455728	229	0.0027378416162882097	1.584783	26	28	0.002363207	
Mouse Phenotype	decreased creatinine clearance	424	5.125705e-10	1.1558222996462263e-8	2.642343	54	0.002797782	411	0.03410313322627737	1.606296	16	17	0.001454281