# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	24	1.509102e-39	8.2742805075e-37	2.21639	343	0.02674881	196	1.9590635808163265e-7	1.440745	139	213	0.01634333	
GO Biological Process	nuclear-transcribed mRNA catabolic process	31	7.829936e-36	3.323681542709678e-33	2.215213	310	0.02417531	216	7.561082202314815e-7	1.438389	129	198	0.01516755	
GO Biological Process	RNA catabolic process	33	2.199349e-35	8.770070754848485e-33	2.042442	369	0.02877642	192	1.2034392108854166e-7	1.419929	155	241	0.01822457	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	41	1.882862e-33	6.043068550731707e-31	2.518475	223	0.01739063	811	0.03053459142786683	1.309026	67	113	0.007877719	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	52	4.897138e-31	1.2392584411923077e-28	2.666903	186	0.01450519	226	0.000001765162234159292	1.552916	83	118	0.009758965	
GO Biological Process	regulation of DNA-templated transcription in response to stress	54	9.754995e-30	2.3771477630555556e-27	2.316291	232	0.01809249	733	0.019839984075034105	1.317235	71	119	0.008348031	
GO Biological Process	plasma lipoprotein particle organization	65	2.499181e-27	5.059495812153846e-25	3.237312	120	0.009358185	550	0.004942910384909091	1.605644	32	44	0.003762493	
GO Biological Process	protein-lipid complex subunit organization	66	3.99034e-27	7.955891524242424e-25	3.095862	127	0.009904079	525	0.003906480999047619	1.597103	34	47	0.003997648	
GO Biological Process	multi-organism metabolic process	70	1.079795e-26	2.0298603435714287e-24	2.226426	225	0.0175466	222	0.000001184596297162162	1.501878	100	147	0.01175779	
GO Biological Process	cotranslational protein targeting to membrane	74	8.355095e-26	1.4857391230405407e-23	2.655995	154	0.01200967	255	0.0000070644891360784304	1.576972	70	98	0.008230453	
GO Biological Process	liver regeneration	77	1.426265e-25	2.4374313162337658e-23	3.154788	116	0.009046245	352	0.0002015435430681818	1.829287	29	35	0.003409759	
GO Biological Process	plasma lipoprotein particle assembly	81	4.104722e-25	6.668399604691359e-23	4.247683	78	0.00608282	725	0.018928595313103445	1.698277	20	26	0.002351558	
GO Biological Process	protein targeting to ER	83	7.09507e-25	1.1248677846987952e-22	2.570038	157	0.01224362	248	0.000005499013448790322	1.573849	72	101	0.008465608	
GO Biological Process	plasma lipoprotein particle remodeling	85	8.538613e-25	1.321877746670588e-22	3.622314	93	0.007252593	602	0.007462742135049834	1.734669	22	28	0.002586714	
GO Biological Process	endoplasmic reticulum unfolded protein response	89	3.518306e-24	5.201953781348314e-22	2.282457	192	0.0149731	613	0.008174188334257749	1.355642	70	114	0.008230453	
GO Biological Process	protein-lipid complex assembly	90	3.603402e-24	5.268574102000001e-22	3.808644	85	0.006628714	700	0.015197114796285714	1.674853	22	29	0.002586714	
GO Biological Process	viral gene expression	92	7.730306e-24	1.1056858331956521e-21	2.337411	180	0.01403728	228	0.0000021138190509649123	1.529787	88	127	0.01034685	
GO Biological Process	viral transcription	93	8.266261e-24	1.169631489236559e-21	2.396354	171	0.01333541	197	2.3376629515228428e-7	1.602091	82	113	0.009641387	
GO Biological Process	negative regulation of protein ubiquitination	101	5.060819e-23	6.5935957644554455e-21	2.058822	230	0.01793652	367	0.0003226239717929156	1.407847	88	138	0.01034685	
GO Biological Process	mRNA transport	104	5.797926e-23	7.336048868653847e-21	2.024739	239	0.01863838	161	1.4198046082608694e-8	1.572651	104	146	0.0122281	
GO Cellular Component	ribosomal subunit	34	1.646791e-27	8.36957308235294e-26	2.177418	244	0.01902831	37	2.1374949016216218e-10	1.551399	130	185	0.01528513	
GO Cellular Component	chylomicron	38	2.31213e-26	1.0514106947368421e-24	6.197223	57	0.004445138	124	0.03201701109677419	1.892366	12	14	0.001410935	
GO Cellular Component	large ribosomal subunit	47	1.196542e-19	4.3992012255319154e-18	2.278456	154	0.01200967	67	0.00000822484671044776	1.516635	79	115	0.009288654	
GO Cellular Component	catalytic step 2 spliceosome	55	1.20339e-17	3.7808325818181823e-16	2.159263	154	0.01200967	66	0.0000029538327272727275	1.586828	69	96	0.008112875	
GO Cellular Component	mitochondrial ribosome	56	2.326191e-17	7.1779608e-16	2.586237	105	0.008188411	63	0.000001664795794285714	1.63634	63	85	0.007407407	
GO Cellular Component	mitochondrial large ribosomal subunit	64	6.80391e-14	1.8370557e-12	2.859364	69	0.005380956	86	0.001454877343255814	1.601708	37	51	0.004350382	
GO Cellular Component	proteasome complex	70	2.093176e-13	5.167154468571428e-12	2.243811	104	0.008110427	90	0.0031156723200000003	1.493485	46	68	0.005408583	
GO Cellular Component	endopeptidase complex	71	2.163643e-13	5.2658804281690146e-12	2.242544	104	0.008110427	96	0.00492993	1.47184	46	69	0.005408583	
GO Cellular Component	high-density lipoprotein particle	73	1.753977e-12	4.151879802739726e-11	3.417898	47	0.003665289	125	0.031931974656	1.635378	20	27	0.002351558	
GO Cellular Component	host cell	82	3.052045e-11	6.431626536585367e-10	2.023696	108	0.008422366	102	0.006930586164705883	1.461018	45	68	0.005291005	
GO Cellular Component	spliceosomal snRNP complex	101	1.613341e-10	2.760250740594059e-9	2.22524	80	0.00623879	99	0.005155625890909091	1.495579	42	62	0.004938272	
GO Cellular Component	small ribosomal subunit	106	4.147644e-10	6.761442294339622e-9	2.04385	93	0.007252593	70	0.000024103496777142856	1.625157	53	72	0.006231628	
GO Cellular Component	small nuclear ribonucleoprotein complex	118	2.768174e-9	4.053732772881356e-8	2.015536	87	0.006784684	96	0.00492993	1.47184	46	69	0.005408583	
GO Cellular Component	cytosolic large ribosomal subunit	119	3.915117e-9	5.685144685714286e-8	2.009074	86	0.006706699	113	0.016950471929203542	1.447712	40	61	0.004703116	
GO Cellular Component	cytosolic small ribosomal subunit	132	5.911213e-8	7.738315200000001e-7	2.10211	65	0.005069017	84	0.0012231567771428572	1.65582	33	44	0.003880071	
GO Cellular Component	spherical high-density lipoprotein particle	137	1.024123e-7	0.0000012917405430656934	4.537461	19	0.001481713	120	0.0254662416	2.20776	8	8	0.0009406232	
GO Cellular Component	U1 snRNP	149	5.287124e-7	0.000006131644477852349	2.592748	36	0.002807455	87	0.0015725286620689653	1.975364	17	19	0.001998824	
GO Cellular Component	mitochondrial small ribosomal subunit	274	0.0002798857	0.0017651185751824815	2.049686	30	0.002339546	115	0.0206378496	1.65582	21	28	0.002469136	
GO Cellular Component	Ino80 complex	307	0.0008407639	0.004732377912703583	2.457783	17	0.001325743	106	0.009951033599999999	1.93179	14	16	0.001646091	
GO Cellular Component	INO80-type complex	348	0.002567707	0.012749993379310345	2.013801	21	0.001637682	114	0.02013385263157895	1.727812	18	23	0.002116402	
GO Molecular Function	structural constituent of ribosome	9	2.264362e-23	1.0622373737777778e-20	2.119999	218	0.0170007	14	7.029804911428571e-8	1.539981	113	162	0.0132863	
GO Molecular Function	unfolded protein binding	10	6.207366e-21	2.6207499252e-18	2.39494	149	0.01161975	55	0.0009844360636363635	1.457955	70	106	0.008230453	
GO Molecular Function	rRNA binding	19	1.209659e-15	2.6879896305263155e-13	2.951144	75	0.005848865	80	0.013755988462500002	1.508636	41	60	0.004820694	
GO Molecular Function	proteasome binding	137	0.00000313343	0.00009656453620437957	2.591189	31	0.002417531	109	0.0446158106972477	2.02378	11	12	0.001293357	
Human Phenotype	Hypoglycemia	5	9.66809e-22	1.2903032914e-18	2.071774	213	0.01661078	83	0.0021384384237349394	1.426252	73	113	0.008583186	
Human Phenotype	Jaundice	21	8.267281e-16	2.6270269577619044e-13	2.096678	146	0.01138579	139	0.01903654237122302	1.43361	50	77	0.005878895	
Human Phenotype	Increased CSF lactate	27	2.578733e-14	6.373290855185185e-12	2.547899	87	0.006784684	70	0.0007228483398857144	1.636788	43	58	0.00505585	
Human Phenotype	Abnormal CSF metabolite level	30	5.402228e-14	1.2016355814666666e-11	2.440016	92	0.007174608	68	0.0007193503813235294	1.612015	46	63	0.005408583	
Human Phenotype	Exercise intolerance	31	1.888095e-13	4.0642767532258066e-11	2.323338	97	0.007564532	124	0.00980328277419355	1.482353	47	70	0.005526161	
Human Phenotype	Glycosuria	45	1.872691e-11	2.7769926762222218e-9	2.577672	66	0.005147001	171	0.03154723577660819	1.674853	22	29	0.002586714	
Human Phenotype	Renal tubular dysfunction	63	7.924764e-10	8.393960344761905e-8	2.113006	83	0.006472744	180	0.036058723275	1.594493	26	36	0.003057025	
Human Phenotype	Abnormality of monocarboxylic acid metabolism	150	7.691356e-7	0.00003421627905866667	2.512441	37	0.00288544	152	0.024673935535526315	2.037932	12	13	0.001410935	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	370	0.0003973125	0.007165584628378378	2.350875	21	0.001637682	184	0.039130907195652175	1.8398	15	18	0.001763668	
Human Phenotype	Increased hepatocellular lipid droplets	375	0.0004502208	0.0080115290624	2.44973	19	0.001481713	98	0.005056238323265306	2.20776	12	12	0.001410935	
Mouse Phenotype Single KO	pale liver	26	5.098997e-18	1.795827520346154e-15	2.139146	161	0.01255556	192	0.014052809127083331	1.435044	52	80	0.006114051	
Mouse Phenotype Single KO	increased hepatocyte proliferation	38	1.685685e-15	4.062057248684211e-13	3.555111	57	0.004445138	256	0.04120124187890625	2.02378	11	12	0.001293357	
Mouse Phenotype Single KO	abnormal DNA replication	297	0.000001547702	0.00004771820610774411	2.262049	43	0.003353349	268	0.04538438125	1.727812	18	23	0.002116402	
Mouse Phenotype Single KO	increased circulating ammonia level	345	0.000005541593	0.00014708512203188406	2.434455	33	0.002573501	214	0.024049183142990656	2.037932	12	13	0.001410935	
Mouse Phenotype	increased hepatocyte proliferation	146	4.779172e-11	3.1297029789041095e-9	2.145044	92	0.007174608	312	0.014538655787499999	1.64005	26	35	0.003057025	
Mouse Phenotype	decreased liver cholesterol level	192	1.39704e-9	6.956822624999999e-8	2.154185	77	0.006004835	189	0.0016792333352380951	1.793805	26	32	0.003057025