# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	24	7.90365e-18	4.33350543125e-15	2.483572	116	0.01714962	191	0.00002124482657591623	1.696405	64	113	0.01020896	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	25	1.356108e-17	7.1380100688e-15	2.691011	99	0.01463631	196	0.000025564841949489797	1.675289	66	118	0.01052799	
GO Biological Process	regulation of DNA-templated transcription in response to stress	34	1.201294e-15	4.649361101764706e-13	2.27129	120	0.01774098	184	0.000015940054527173914	1.686381	67	119	0.01068751	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	48	1.405718e-13	3.853717325416667e-11	2.653218	76	0.01123596	315	0.001139692635079365	1.627834	50	92	0.007975754	
GO Biological Process	cotranslational protein targeting to membrane	51	1.789411e-13	4.617031244901961e-11	2.582972	79	0.01167948	265	0.0003836516381320755	1.650424	54	98	0.008613814	
GO Biological Process	viral gene expression	52	2.075689e-13	5.252690682884615e-11	2.338687	95	0.01404494	347	0.0020134707251008646	1.509399	64	127	0.01020896	
GO Biological Process	protein targeting to ER	64	2.243511e-12	4.6128689451562505e-10	2.451619	79	0.01167948	354	0.0021237298948305087	1.571746	53	101	0.008454299	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	65	2.358738e-12	4.775174360307693e-10	2.449043	79	0.01167948	359	0.0022831495459052923	1.651208	43	78	0.006859148	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	67	2.712844e-12	5.32810659641791e-10	2.339272	86	0.01271437	296	0.0008591293265202703	1.597448	56	105	0.008932844	
GO Biological Process	multi-organism metabolic process	72	5.910487e-12	1.080223589347222e-9	2.0635	110	0.01626257	285	0.0006992392482456141	1.507795	74	147	0.01180412	
GO Biological Process	viral transcription	73	8.777075e-12	1.5821579441780822e-9	2.284754	86	0.01271437	357	0.002213214052997199	1.537367	58	113	0.009251874	
GO Biological Process	protein localization to endoplasmic reticulum	79	1.989793e-11	3.3143906439240507e-9	2.148174	95	0.01404494	374	0.003252439309171123	1.497607	62	124	0.009889935	
GO Biological Process	translational elongation	81	2.689719e-11	4.3696311507407405e-9	2.270437	83	0.01227085	157	0.0000020821267780254778	1.765037	66	112	0.01052799	
GO Biological Process	mitochondrial translation	91	7.11324e-11	1.028605770989011e-8	2.30394	77	0.0113838	150	0.0000015798458538	1.79153	64	107	0.01020896	
GO Biological Process	mitochondrial translational termination	100	1.928387e-10	2.5375644533000002e-8	2.48965	63	0.009314015	198	0.000026219659735858586	1.790243	52	87	0.008294784	
GO Biological Process	mitochondrial transmembrane transport	104	3.232219e-10	4.089689405865385e-8	2.297289	72	0.01064459	442	0.0118286251	1.551738	43	83	0.006859148	
GO Biological Process	mitochondrial translational elongation	111	6.638519e-10	7.869934371261263e-8	2.450579	61	0.009018332	200	0.000028306443331	1.797129	51	85	0.008135269	
GO Biological Process	DNA-templated transcription, termination	126	3.148009e-9	3.287670669126984e-7	2.109833	77	0.0113838	178	0.00001027661715505618	1.731179	63	109	0.01004945	
GO Biological Process	transcription from RNA polymerase III promoter	131	4.514414e-9	4.534746093587787e-7	2.815034	43	0.006357185	240	0.00013411027747499998	2.068124	29	42	0.004625937	
GO Biological Process	translational termination	134	5.717536e-9	5.614705688358209e-7	2.209532	67	0.009905381	214	0.00004848610643084112	1.734072	55	95	0.008773329	
GO Cellular Component	ribosomal subunit	23	1.798224e-19	1.3510135095652174e-17	2.36846	140	0.02069781	34	4.3426942305882355e-8	1.651416	102	185	0.01627054	
GO Cellular Component	mitochondrial ribosome	29	5.775153e-12	3.441194615172414e-10	2.801665	60	0.008870491	52	0.00004275600369230769	1.761891	50	85	0.007975754	
GO Cellular Component	large ribosomal subunit	36	4.480365e-11	2.1505751999999995e-9	2.271909	81	0.01197516	71	0.0012891554163380282	1.536675	59	115	0.009411389	
GO Cellular Component	small ribosomal subunit	40	4.402957e-10	1.902077424e-8	2.499789	60	0.008870491	59	0.00011833496298305087	1.788809	43	72	0.006859148	
GO Cellular Component	DNA-directed RNA polymerase III complex	47	2.517099e-9	9.254355472340426e-8	5.43963	20	0.00295683	107	0.030630205009345792	2.049357	13	19	0.002073696	
GO Cellular Component	mitochondrial large ribosomal subunit	50	7.66611e-9	2.6494076159999997e-7	2.985314	38	0.005617978	86	0.009557694586046512	1.703161	29	51	0.004625937	
GO Cellular Component	cytosolic small ribosomal subunit	61	5.034122e-7	0.00001426059478032787	2.452382	40	0.005913661	99	0.020402286545454548	1.701826	25	44	0.003987877	
GO Cellular Component	Ino80 complex	79	0.000006873942	0.00015035660475949369	4.111231	15	0.002217623	93	0.014894090941935483	2.246411	12	16	0.001914181	
GO Cellular Component	INO80-type complex	87	0.00001873347	0.0003720854731034483	3.272321	18	0.002661147	105	0.029125341257142858	1.953401	15	23	0.002392726	
GO Cellular Component	mitochondrial small ribosomal subunit	122	0.0001593357	0.002256820406557377	2.590492	20	0.00295683	91	0.015092530496703296	1.925495	18	28	0.002871271	
GO Molecular Function	structural constituent of ribosome	7	3.582176e-14	2.160563867428571e-11	2.17544	118	0.0174453	25	0.0000021148639744	1.645519	89	162	0.01419684	
GO Molecular Function	RNA polymerase III activity	18	2.795427e-8	0.00000655682933	5.224885	18	0.002661147	116	0.029175173770689653	2.246411	12	16	0.001914181	
GO Molecular Function	5S rRNA binding	21	6.848118e-7	0.0001376797818857143	4.987239	15	0.002217623	131	0.04465312893129771	2.45063	9	11	0.001435636	
GO Molecular Function	mRNA 5'-UTR binding	60	0.00008141263	0.0057287353976666665	2.518611	23	0.003400355	119	0.031565871697478994	2.042192	15	22	0.002392726	
Human Phenotype	Laryngomalacia	2	4.706807e-10	0.00000157042615555	3.890578	31	0.004583087	52	0.010669699671346152	2.567327	12	14	0.001914181	
Human Phenotype	Ankle contracture	3	1.458962e-9	0.0000032452178086666667	4.847546	23	0.003400355	52	0.010669699671346152	2.567327	12	14	0.001914181	
Mouse Phenotype Single KO	increased fibroblast apoptosis	4	3.85715e-10	8.829980637499999e-7	2.783894	50	0.007392076	98	0.0020531414269387756	2.053861	24	35	0.003828362	
Mouse Phenotype Single KO	increased integument system tumor incidence	6	8.212154e-10	0.0000012533115696333334	2.217695	74	0.01094027	188	0.01999791872180851	1.576429	40	76	0.006380603	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	9	8.063004e-9	0.000008203658625333333	2.323607	59	0.008722649	199	0.021022424329145726	1.647368	33	60	0.005263997	
Mouse Phenotype Single KO	early cellular replicative senescence	12	2.497439e-8	0.000019057540769166666	2.367054	53	0.0078356	225	0.029898480002222224	1.670408	29	52	0.004625937	
Mouse Phenotype Single KO	increased mammary gland tumor incidence	26	0.000001641683	0.0005781881242692307	2.363941	39	0.005765819	144	0.010345693062500001	1.891714	24	38	0.003828362	
Mouse Phenotype Single KO	abnormal interventricular septum thickness	42	0.000004665095	0.001017101783690476	2.011224	51	0.007539917	164	0.013649781546341463	1.81106	26	43	0.004147392	
Mouse Phenotype	increased fibroblast apoptosis	2	4.133098e-11	1.9758274988999998e-7	2.662749	60	0.008870491	151	0.0006013636623377484	1.934409	31	48	0.004944967	
Mouse Phenotype	abnormal cellular replicative senescence	7	6.653108e-10	9.087195084e-7	2.129155	82	0.012123	189	0.0022159266646031746	1.640237	46	84	0.007337693	
Mouse Phenotype	early cellular replicative senescence	11	1.952176e-9	0.0000016967958850909093	2.171643	74	0.01094027	196	0.0025182869119897955	1.682244	41	73	0.006540118	
Mouse Phenotype	increased squamous cell carcinoma incidence	12	4.216195e-9	0.0000033592533662499994	2.197766	69	0.01020106	269	0.009606459178438661	1.728008	30	52	0.004785452	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	61	0.00003791358	0.005942487514426229	2.385077	28	0.004139562	340	0.021001009269705884	1.896969	19	30	0.003030786	
Mouse Phenotype	increased cellular sensitivity to DNA damaging agents	103	0.0001789821	0.016614056874757283	2.136367	29	0.004287404	363	0.023433826628099175	2.042192	15	22	0.002392726