# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 4 3.00385e-32 9.881915537500001e-29 4.214852 102 0.0228239 215 0.0011645323290232557 1.72159 49 114 0.01045222 GO Biological Process chromatin silencing 12 6.68741e-27 7.333302349166666e-24 4.701004 75 0.01678228 262 0.0029757626991984733 1.734268 42 97 0.008959044 GO Biological Process regulation of gene expression, epigenetic 16 8.834872e-25 7.2661300405e-22 2.454344 168 0.0375923 269 0.003744258924907063 1.437398 89 248 0.01898464 GO Biological Process gene silencing 37 2.476392e-19 8.807254683243244e-17 2.599733 116 0.02595659 253 0.0024489247479446644 1.535378 69 180 0.01471843 GO Biological Process chromatin assembly 44 5.832498e-18 1.7443145723181819e-15 2.535513 112 0.02506154 368 0.012912869486956522 1.495662 59 158 0.01258532 GO Biological Process chromatin assembly or disassembly 49 5.072685e-17 1.3622747329591836e-14 2.380737 119 0.02662788 376 0.013499594117021278 1.462622 65 178 0.01386519 GO Biological Process nucleosome assembly 58 8.864732e-16 2.0112242825517242e-13 2.50957 99 0.02215261 373 0.013210729334316355 1.523155 54 142 0.01151877 GO Biological Process nucleosome organization 71 5.272951e-15 9.77278340971831e-13 2.320534 109 0.02439024 420 0.02011433983857143 1.452226 62 171 0.01322526 GO Biological Process regulation of gene silencing 77 2.710281e-14 4.631764633636364e-12 2.504747 89 0.01991497 300 0.006061974075333333 1.589903 52 131 0.01109215 GO Biological Process regulation of posttranscriptional gene silencing 84 7.113394e-14 1.1143470434047621e-11 2.645925 78 0.01745357 260 0.0029593583830384617 1.690324 46 109 0.009812287 GO Biological Process regulation of gene silencing by RNA 84 7.113394e-14 1.1143470434047621e-11 2.645925 78 0.01745357 260 0.0029593583830384617 1.690324 46 109 0.009812287 GO Biological Process regulation of megakaryocyte differentiation 91 1.313739e-13 1.899724340769231e-11 2.86086 67 0.01499217 551 0.04130184999818512 1.633754 31 76 0.006612628 GO Biological Process regulation of gene silencing by miRNA 96 4.167698e-13 5.712785206458333e-11 2.60841 75 0.01678228 297 0.005888683514478115 1.662591 44 106 0.009385666 GO Biological Process regulation of stem cell differentiation 103 1.934374e-12 2.471303637475728e-10 2.082699 112 0.02506154 562 0.045789292690391455 1.448737 51 141 0.01087884 GO Biological Process regulation of regulatory T cell differentiation 113 1.331939e-11 1.551060646106195e-9 3.364641 44 0.009845603 179 0.0005227292187094972 2.723626 17 25 0.00362628 GO Biological Process mitochondrial membrane organization 129 4.576174e-11 4.668052222170542e-9 2.170882 89 0.01991497 459 0.02695919879368192 1.51815 47 124 0.0100256 GO Biological Process negative regulation of immune response 130 4.827183e-11 4.886223161307693e-9 2.079987 98 0.02192884 546 0.04057840347985348 1.482289 47 127 0.0100256 GO Biological Process cellular response to amino acid starvation 218 7.237466e-9 4.3687071144036703e-7 2.594054 48 0.01074066 553 0.04152985159132007 1.862945 20 43 0.004266212 GO Biological Process nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 246 2.578242e-8 0.0000013791498568292684 2.485864 48 0.01074066 557 0.043525908538599646 1.67387 28 67 0.005972696 GO Biological Process regulation of immunoglobulin production 260 3.810794e-8 0.000001928701471 2.676028 41 0.009174312 471 0.02888082001910828 1.788095 25 56 0.005332765 GO Cellular Component nucleosome 20 5.138943e-26 4.440046752e-24 4.661833 73 0.01633475 30 0.000171027936 1.831009 48 105 0.01023891 GO Cellular Component DNA packaging complex 25 1.573993e-21 1.0879439616e-19 3.836835 74 0.01655851 36 0.00051116688 1.752333 49 112 0.01045222 GO Cellular Component protein-DNA complex 45 1.892735e-11 7.2681024e-10 2.017902 110 0.02461401 45 0.00545670912 1.4673 74 202 0.01578498 GO Cellular Component transcription factor AP-1 complex 69 3.013634e-7 0.000007547187756521739 7.798581 11 0.002461401 53 0.03157762523773585 4.005333 5 5 0.001066553 GO Cellular Component nuclear envelope lumen 208 0.004243032 0.035249804307692305 2.215039 15 0.003356456 48 0.013569055200000001 3.504666 7 8 0.001493174 GO Molecular Function protein binding involved in protein folding 17 1.211096e-9 3.007792536470588e-7 4.199605 27 0.00604162 57 0.048777077094736845 2.225185 15 27 0.003199659 Mouse Phenotype Single KO abnormal platelet aggregation 18 2.293246e-23 1.1666252012222222e-20 3.254434 100 0.02237637 124 0.00036072125791935486 1.951316 38 78 0.008105802 Mouse Phenotype Single KO abnormal platelet activation 21 1.076442e-22 4.6937997114285717e-20 3.161108 101 0.02260013 159 0.001264899027484277 1.837741 39 85 0.008319113 Mouse Phenotype Single KO abnormal platelet physiology 31 9.322546e-20 2.7537597974838713e-17 2.621845 117 0.02618035 147 0.0008841669049659864 1.747782 48 110 0.01023891 Mouse Phenotype Single KO decreased platelet aggregation 43 1.305185e-16 2.7794369872093023e-14 3.255666 69 0.0154397 197 0.0035205569283248733 1.935911 29 60 0.006186007 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 46 2.244216e-16 4.467453459130435e-14 2.266933 126 0.02819423 185 0.002746319427621622 1.586004 59 149 0.01258532 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 48 6.219609e-16 1.1865199919375e-13 2.774317 84 0.01879615 222 0.005321578175675676 1.96488 26 53 0.005546075 Mouse Phenotype Single KO abnormal erythropoiesis 57 3.535822e-15 5.680267027017543e-13 2.221327 121 0.02707541 171 0.0017950199351461989 1.711369 47 110 0.0100256 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 71 2.761374e-13 3.561394608169014e-11 2.142244 113 0.0252853 189 0.0029037152233333335 1.557629 63 162 0.01343857 Mouse Phenotype Single KO abnormal T-helper 2 physiology 98 2.796823e-11 2.613317164387755e-9 2.635885 62 0.01387335 173 0.0018100684244508668 2.002666 29 58 0.006186007 Mouse Phenotype Single KO improved central nervous system regeneration 111 2.108839e-10 1.739697182252252e-8 7.196339 18 0.004027747 345 0.025706663744637683 4.005333 5 5 0.001066553 Mouse Phenotype Single KO increased bleeding time 141 3.772662e-9 2.450089782553191e-7 2.109191 76 0.01700604 348 0.025583226560919544 1.640739 34 83 0.00725256 Mouse Phenotype Single KO abnormal circulating tumor necrosis factor level 148 9.140617e-9 5.655447964121621e-7 2.193861 66 0.0147684 405 0.04392809605925926 1.525841 40 105 0.008532423 Mouse Phenotype Single KO increased pre-B cell number 160 2.26261e-8 0.0000012949199856249998 2.959076 36 0.008055493 335 0.02448114109641791 2.242986 14 25 0.002986348 Mouse Phenotype Single KO decreased susceptibility to experimental autoimmune encephalomyelitis 232 8.640593e-7 0.000034104271595258616 2.101902 53 0.01185948 430 0.04850345775581395 1.623784 30 74 0.006399317 Mouse Phenotype Single KO persistent right dorsal aorta 300 0.000007320371 0.00022344212415666666 2.61964 28 0.006265384 414 0.04698753085990339 2.574857 9 14 0.001919795 Mouse Phenotype Single KO vascular inflammation 307 0.000008842041 0.00026373475386644947 2.769488 25 0.005594093 319 0.018903182621943574 2.225185 15 27 0.003199659 Mouse Phenotype Single KO abnormal coronal suture morphology 330 0.00001777479 0.0004932234910000001 2.594798 26 0.005817856 284 0.012435312401760563 3.004 9 12 0.001919795 Mouse Phenotype Single KO vasculitis 393 0.00007169945 0.0016706154291348599 2.603365 22 0.004922802 367 0.030391733686648506 2.263884 13 23 0.002773038 Mouse Phenotype Single KO increased mesenteric fat pad weight 417 0.0001117698 0.002454379037410072 4.484414 10 0.002237637 345 0.025706663744637683 4.005333 5 5 0.001066553 Mouse Phenotype Single KO abnormal forelimb bud morphology 458 0.0002041204 0.004081070966812227 2.310273 24 0.005370329 209 0.004612880372727272 3.560296 8 9 0.001706485 Mouse Phenotype abnormal platelet aggregation 20 4.898296e-24 2.3416304027999998e-21 3.169283 107 0.02394272 196 0.00045612852944387755 1.832227 43 94 0.009172355 Mouse Phenotype abnormal platelet physiology 22 1.443447e-23 6.2730894395454555e-21 2.681105 136 0.03043186 169 0.00019686223462721893 1.729576 57 132 0.0121587 Mouse Phenotype abnormal platelet activation 24 1.966112e-23 7.83249868e-21 3.11026 107 0.02394272 271 0.0020933287349446496 1.722293 43 100 0.009172355 Mouse Phenotype decreased platelet aggregation 48 2.710349e-17 5.398676414374999e-15 3.167257 75 0.01678228 302 0.002980218786556291 1.835778 33 72 0.007039249 Mouse Phenotype decreased susceptibility to autoimmune disorder 60 2.173922e-15 3.464144707e-13 2.129172 135 0.0302081 275 0.002148881685818182 1.492183 76 204 0.0162116 Mouse Phenotype abnormal embryonic hematopoiesis 61 2.875983e-15 4.507749748032787e-13 2.592224 90 0.02013873 249 0.0014497202228915664 1.969836 30 61 0.006399317 Mouse Phenotype abnormal erythropoiesis 62 3.120995e-15 4.812876321774194e-13 2.079626 141 0.03155068 204 0.0005930533636764706 1.639767 61 149 0.01301195 Mouse Phenotype joint inflammation 96 9.753073e-12 9.7134511409375e-10 2.06475 107 0.02394272 449 0.01689673580846325 1.461065 58 159 0.01237201 Mouse Phenotype atherosclerotic lesions 98 1.178356e-11 1.1496185424489796e-9 2.155632 96 0.02148132 371 0.007250289273315364 1.616832 44 109 0.009385666 Mouse Phenotype arteriosclerosis 105 4.54303e-11 4.136753317142857e-9 2.082401 98 0.02192884 348 0.005752606432758621 1.616187 46 114 0.009812287 Mouse Phenotype abnormal interferon level 106 4.796258e-11 4.326134220566038e-9 2.264713 81 0.01812486 600 0.036660108805 1.456485 48 132 0.01023891 Mouse Phenotype abnormal circulating tumor necrosis factor level 121 2.50262e-10 1.9774834561983468e-8 2.086341 90 0.02013873 408 0.010231837722794117 1.508858 55 146 0.01173208 Mouse Phenotype decreased susceptibility to experimental autoimmune encephalomyelitis 123 3.341293e-10 2.5972440953658537e-8 2.248019 75 0.01678228 471 0.019972094696178347 1.563987 41 105 0.008745734 Mouse Phenotype improved central nervous system regeneration 124 3.594638e-10 2.771639832096774e-8 6.497101 19 0.00425151 512 0.024830906712890625 3.433142 6 7 0.001279863 Mouse Phenotype abnormal late pro-B cell 145 1.551149e-9 1.0227955578620689e-7 4.828348 23 0.005146565 683 0.048552815784773065 2.803733 7 10 0.001493174 Mouse Phenotype abnormal T-helper 2 physiology 154 3.172401e-9 1.9695666208441557e-7 2.273274 65 0.01454464 277 0.0021955248752707577 1.884862 32 68 0.006825939 Mouse Phenotype increased bleeding time 159 3.853734e-9 2.3173302373584905e-7 2.052556 81 0.01812486 453 0.01837808877152318 1.602133 38 95 0.008105802 Mouse Phenotype pale liver 165 5.703928e-9 3.3051670065454547e-7 2.004342 84 0.01879615 637 0.0413806684144427 1.492897 41 110 0.008745734 Mouse Phenotype abnormal neural fold morphology 171 1.3174e-8 7.365883859649123e-7 2.09166 72 0.01611099 422 0.012864393469194312 1.8024 27 60 0.005759386 Mouse Phenotype abnormal third pharyngeal arch artery morphology 180 2.46436e-8 0.0000013089858866666667 2.849147 38 0.008503021 390 0.008911413402307692 2.479492 13 21 0.002773038