# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	IRE1-mediated unfolded protein response	18	3.75202e-51	2.742935065555556e-48	3.445536	213	0.009915739	424	0.0006677581103066039	1.417556	50	58	0.004378667	
GO Biological Process	endoplasmic reticulum unfolded protein response	19	6.583148e-51	4.559349712210526e-48	2.497924	352	0.01638657	368	0.00014339988067663044	1.327031	92	114	0.008056748	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	1.653333e-50	1.08781044735e-47	2.447228	363	0.01689865	402	0.00046417325017412937	1.309671	90	113	0.007881601	
GO Biological Process	regulation of DNA-templated transcription in response to stress	25	9.878572e-46	5.19968515792e-43	2.270729	381	0.0177366	380	0.00023671721637105264	1.312728	95	119	0.008319468	
GO Biological Process	cellular response to topologically incorrect protein	26	6.362149e-45	3.219981488115384e-42	2.226906	390	0.01815558	384	0.00024297462964583335	1.289466	109	139	0.009545494	
GO Biological Process	cellular response to unfolded protein	29	7.836046e-44	3.5556734246206895e-41	2.281548	361	0.01680555	366	0.00013951995136338797	1.31821	97	121	0.008494614	
GO Biological Process	response to topologically incorrect protein	30	1.053134e-43	4.619396768666667e-41	2.024743	473	0.02201946	299	0.000006869380887290971	1.297221	142	180	0.01243541	
GO Biological Process	nuclear-transcribed mRNA catabolic process	32	1.02675e-42	4.222188515625e-40	2.009138	471	0.02192635	150	3.1701531126e-11	1.386914	167	198	0.01462475	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	34	5.128427e-42	1.9848520850882354e-39	2.028592	452	0.02104185	627	0.011997435971610846	1.209404	114	155	0.009983361	
GO Biological Process	response to unfolded protein	38	3.201185e-40	1.1085366688157894e-37	2.021134	436	0.02029701	297	0.000006379611688552188	1.315492	128	160	0.01120939	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	56	2.068582e-34	4.860798310357143e-32	2.319523	271	0.0126158	264	0.0000020420933715151516	1.379594	99	118	0.008669761	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	87	5.773945e-28	8.733257730459771e-26	2.254916	231	0.01075369	661	0.016628564450226927	1.285977	61	78	0.005341974	
GO Biological Process	cotranslational protein targeting to membrane	95	5.937509e-27	8.224387466421054e-25	2.26498	220	0.01024161	273	0.0000028315936272161175	1.409455	84	98	0.007356161	
GO Biological Process	translational elongation	105	5.010851e-26	6.2797893627619046e-24	2.118925	246	0.01145198	185	1.127707094972973e-9	1.468183	100	112	0.008757334	
GO Biological Process	protein targeting to ER	109	6.600263e-26	7.96815236853211e-24	2.198657	225	0.01047437	280	0.000003702270081107143	1.400152	86	101	0.007531307	
GO Biological Process	viral gene expression	125	3.768111e-24	3.9667658119199996e-22	2.007694	259	0.01205717	172	4.957188094651163e-10	1.450148	112	127	0.009808214	
GO Biological Process	mitochondrial translational termination	126	4.827956e-24	5.042148651111111e-22	2.314514	186	0.008658815	207	1.9480704383091786e-8	1.493159	79	87	0.006918294	
GO Biological Process	mitochondrial transmembrane transport	129	1.379765e-23	1.407467258527132e-21	2.150038	214	0.009962292	496	0.0021378419150806455	1.327379	67	83	0.005867414	
GO Biological Process	mitochondrial translational elongation	132	2.537195e-23	2.5293143185606063e-21	2.302287	182	0.008472604	215	4.2142811424651165e-8	1.489601	77	85	0.006743147	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	133	2.768569e-23	2.7392180053383455e-21	2.187198	203	0.009450212	256	0.000001385725971796875	1.497108	61	67	0.005341974	
GO Cellular Component	mitochondrial ribosome	40	1.80058e-25	7.7785056e-24	2.499557	170	0.00791397	61	1.1093961127868851e-7	1.470255	76	85	0.006655574	
GO Cellular Component	large ribosomal subunit	44	3.851009e-24	1.5123962618181818e-22	2.084333	236	0.01098645	66	8.41572130909091e-7	1.386986	97	115	0.008494614	
GO Cellular Component	catalytic step 2 spliceosome	45	8.943019e-24	3.4341192959999995e-22	2.042254	244	0.01135888	81	0.000030965290666666665	1.370304	80	96	0.007005867	
GO Cellular Component	mitochondrial large ribosomal subunit	52	7.427808e-22	2.4683177353846155e-20	2.84481	115	0.005353568	75	0.000010628209152	1.515395	47	51	0.004115947	
GO Cellular Component	endopeptidase complex	55	3.878037e-20	1.2184087156363638e-18	2.201096	171	0.007960523	118	0.0011625018955932203	1.358388	57	69	0.004991681	
GO Cellular Component	proteasome complex	59	3.96512e-19	1.1613097220338983e-17	2.163702	168	0.007820865	122	0.0015406153967213116	1.354183	56	68	0.004904107	
GO Cellular Component	DNA-directed RNA polymerase III complex	77	6.13384e-15	1.3765292883116884e-13	4.02519	47	0.00218798	117	0.0011556933415384615	1.644365	19	19	0.001663894	
GO Cellular Component	spliceosomal snRNP complex	80	4.225103e-14	9.12622248e-13	2.108753	127	0.005912201	155	0.007536430079999999	1.326101	50	62	0.004378667	
GO Cellular Component	mitochondrial nucleoid	89	2.831171e-13	5.4969252674157306e-12	2.234251	104	0.004841488	101	0.0003242906803960396	1.487758	38	42	0.003327787	
GO Cellular Component	spliceosomal tri-snRNP complex	107	4.775966e-12	7.712961914018692e-11	2.558785	71	0.003305246	188	0.026174512340425532	1.417556	25	29	0.002189334	
GO Cellular Component	methylosome	108	5.107355e-12	8.171768e-11	4.094485	36	0.0016759	185	0.0238457088	1.644365	12	12	0.00105088	
GO Cellular Component	cytoplasmic exosome (RNase complex)	122	2.678788e-11	3.794217757377049e-10	4.267324	32	0.001489689	175	0.01532381513142857	1.644365	13	13	0.001138453	
GO Cellular Component	MLL1 complex	191	1.084237e-7	9.80922270157068e-7	2.066786	65	0.00302593	188	0.026174512340425532	1.417556	25	29	0.002189334	
GO Cellular Component	mRNA cleavage factor complex	218	9.026643e-7	0.0000071550638091743116	2.138636	51	0.002374191	154	0.007421895771428571	1.562146	19	20	0.001663894	
GO Molecular Function	unfolded protein binding	8	5.826685e-40	3.0750330087499997e-37	2.542666	265	0.01233648	51	0.000004340246630196078	1.396159	90	106	0.007881601	
GO Molecular Function	rRNA binding	29	7.827724e-15	1.1396086457931035e-12	2.395877	102	0.004748382	148	0.03454006789189189	1.315492	48	60	0.00420352	
GO Molecular Function	RNA polymerase III activity	66	3.901985e-11	2.4960879803030305e-9	3.564658	39	0.001815558	127	0.011586564251968504	1.644365	16	16	0.001401173	
GO Molecular Function	telomeric DNA binding	83	2.753408e-10	1.400588985060241e-8	2.081179	91	0.004236302	168	0.04604761996428571	1.402546	29	34	0.002539627	
GO Molecular Function	cAMP response element binding	145	3.361149e-8	9.78673867448276e-7	2.231426	59	0.002746613	159	0.04120807422641509	1.644365	13	13	0.001138453	
GO Molecular Function	peptide disulfide oxidoreductase activity	156	5.748816e-8	0.0000015558654584615386	2.759996	38	0.001769005	159	0.04120807422641509	1.644365	13	13	0.001138453	
GO Molecular Function	mannosyltransferase activity	254	0.000004522386	0.0000751713137480315	2.0161	51	0.002374191	141	0.025541773513475176	1.507334	22	24	0.001926614	
Human Phenotype	Abnormal CSF metabolite level	15	6.229683e-20	2.7713783106e-17	2.343158	148	0.00688981	101	0.00023129146554455444	1.435556	55	63	0.004816534	
Human Phenotype	Exercise intolerance	22	2.807966e-16	8.517071417272728e-14	2.116107	148	0.00688981	148	0.0026050454172972973	1.362474	58	70	0.005079254	
Human Phenotype	Increased CSF lactate	32	5.26053e-16	1.0969848965625e-13	2.237732	128	0.005958754	125	0.00114861174552	1.417556	50	58	0.004378667	
Human Phenotype	Progressive macrocephaly	309	0.000007062005	0.00015250731186084143	2.013623	49	0.002281086	244	0.023328307525	1.507334	22	24	0.001926614	
Mouse Phenotype	abnormal hypoglossal nerve topology	65	1.258261e-18	1.8508051416923078e-16	3.113699	84	0.003910432	399	0.03892230382706767	1.553011	17	18	0.001488747	
Mouse Phenotype	absent segment of posterior cerebral artery	130	1.062802e-13	7.81649994e-12	2.513785	85	0.003956985	416	0.04498553924278847	1.494877	20	22	0.001751467	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	148	4.547862e-13	2.937980309594595e-11	2.387171	89	0.004143196	210	0.0029986824464285715	1.53474	28	30	0.002452054	
Mouse Phenotype	increased incidence of tumors by UV-induction	327	2.264292e-8	6.620457434862385e-7	3.142423	33	0.001536241	397	0.03737438249622166	1.644365	13	13	0.001138453	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	463	9.82415e-7	0.000020286975842332615	2.169752	49	0.002281086	364	0.02725864739835165	1.557819	18	19	0.00157632