# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	DNA replication-dependent nucleosome assembly	18	3.9676e-27	2.900536022222222e-24	13.97469	34	0.005582923	299	0.0027644726468227425	2.294001	19	32	0.003909465	
GO Biological Process	translational elongation	19	2.272472e-26	1.5738662656842107e-23	3.34203	110	0.0180624	114	1.4500813995614034e-7	2.035279	59	112	0.01213992	
GO Biological Process	mitochondrial translational termination	38	7.696443e-21	2.6651971957105267e-18	3.511349	80	0.01313629	172	0.000017246782145348838	1.998404	45	87	0.009259259	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	41	8.663108e-20	2.7804350773658535e-17	2.927771	98	0.01609195	346	0.007243759474277456	1.606976	47	113	0.009670782	
GO Biological Process	mitochondrial translational elongation	44	1.354695e-19	4.051461705681818e-17	3.435705	77	0.01264368	187	0.00006450660723582888	1.954517	43	85	0.008847737	
GO Biological Process	translational termination	45	2.045849e-19	5.982517109111111e-17	3.149998	86	0.01412151	173	0.000017359695086127166	1.952125	48	95	0.009876543	
GO Biological Process	chromatin silencing	46	3.192158e-19	9.131653722173913e-17	3.449719	75	0.01231527	387	0.010778958532041343	1.63306	41	97	0.008436214	
GO Biological Process	rRNA processing	48	4.498246e-19	1.2331753982083334e-16	2.14365	169	0.02775041	263	0.0010993939222813688	1.456508	95	252	0.01954733	
GO Biological Process	nuclear-transcribed mRNA catabolic process	49	1.333611e-18	3.5814259487755105e-16	2.24188	149	0.02446634	213	0.00015759712634741784	1.580556	81	198	0.01666667	
GO Biological Process	rRNA metabolic process	50	1.777474e-18	4.6779560732e-16	2.101103	171	0.02807882	272	0.0011896645519117646	1.446978	97	259	0.01995885	
GO Biological Process	mitochondrial translation	52	2.220884e-18	5.620117799230769e-16	2.957718	89	0.01461412	181	0.00002613370856850829	1.877628	52	107	0.01069959	
GO Biological Process	regulation of hematopoietic stem cell differentiation	54	2.486942e-18	6.060309218148148e-16	2.973843	88	0.01444992	388	0.0107692882935567	1.612951	43	103	0.008847737	
GO Biological Process	cellular protein complex disassembly	58	6.752109e-18	1.5319138332931034e-15	2.535271	112	0.0183908	179	0.000022763732045810057	1.809137	59	126	0.01213992	
GO Biological Process	negative regulation of gene expression, epigenetic	59	7.366781e-18	1.6430418843898305e-15	2.820059	93	0.01527094	265	0.0011406529070943396	1.694553	50	114	0.01028807	
GO Biological Process	RNA catabolic process	60	1.116025e-17	2.4476288291666668e-15	2.039548	175	0.02873563	195	0.0000888661685846154	1.53902	96	241	0.01975309	
GO Biological Process	mRNA catabolic process	65	5.091258e-17	1.0307056003384615e-14	2.1089	155	0.02545156	229	0.0002737815569694323	1.541804	85	213	0.01748971	
GO Biological Process	macromolecular complex disassembly	66	9.130487e-17	1.8204254308030303e-14	2.111685	152	0.02495895	183	0.00003247886403224044	1.638482	81	191	0.01666667	
GO Biological Process	regulation of RNA stability	67	9.57818e-17	1.8811831435820895e-14	2.104529	153	0.02512315	222	0.00019768392268918917	1.642022	68	160	0.01399177	
GO Biological Process	regulation of mRNA stability	72	1.519776e-16	2.7776017199999997e-14	2.135294	146	0.02397373	221	0.00019244977957013574	1.663131	65	151	0.01337449	
GO Biological Process	protein complex disassembly	87	1.826071e-15	2.7619848608045973e-13	2.182368	129	0.02118227	191	0.00007902902696858639	1.676648	69	159	0.01419753	
GO Cellular Component	intracellular ribonucleoprotein complex	12	8.009863e-63	1.153420272e-60	2.060445	626	0.1027915	19	1.80086976e-20	1.590048	335	814	0.06893004	
GO Cellular Component	ribonucleoprotein complex	13	1.234917e-62	1.641489673846154e-60	2.057822	626	0.1027915	20	3.517635168e-20	1.58421	335	817	0.06893004	
GO Cellular Component	mitochondrial ribosome	26	6.49048e-24	4.313672861538462e-22	4.045255	78	0.01280788	48	0.000010706284799999999	1.999971	44	85	0.009053498	
GO Cellular Component	ribosome	28	1.152927e-23	7.115206628571429e-22	2.337414	177	0.02906404	34	8.257644423529412e-9	1.735337	106	236	0.0218107	
GO Cellular Component	ribosomal subunit	30	1.567544e-22	9.029053440000001e-21	2.593005	138	0.0226601	33	8.256373527272727e-9	1.837811	88	185	0.018107	
GO Cellular Component	large ribosomal subunit	36	1.409248e-18	6.7643904e-17	2.897178	93	0.01527094	44	5.604245672727273e-7	1.948588	58	115	0.01193416	
GO Cellular Component	nucleosome	37	1.459172e-18	6.814727610810811e-17	3.420974	73	0.01198686	83	0.0023434740433734944	1.65582	45	105	0.009259259	
GO Cellular Component	mitochondrial large ribosomal subunit	44	1.214303e-14	4.768899054545454e-13	4.013752	46	0.007553366	72	0.0008099664	2.045425	27	51	0.005555556	
GO Cellular Component	DNA packaging complex	46	1.683586e-14	6.324427408695653e-13	2.815569	74	0.01215107	95	0.005686082223157895	1.586828	46	112	0.009465021	
GO Cellular Component	catalytic step 2 spliceosome	48	9.964646e-14	3.58727256e-12	2.509436	85	0.01395731	100	0.009144911232	1.609825	40	96	0.008230453	
GO Cellular Component	methyltransferase complex	49	1.226151e-13	4.324059036734694e-12	2.468746	87	0.01428571	50	0.000013749678720000002	1.953019	46	91	0.009465021	
GO Cellular Component	chromosome, telomeric region	52	6.559421e-13	2.1797460553846152e-11	2.149415	109	0.01789819	66	0.0004923624436363636	1.573194	68	167	0.01399177	
GO Cellular Component	nuclear chromosome, telomeric region	54	1.435399e-11	4.5932768e-10	2.236986	88	0.01444992	82	0.002360521756097561	1.580556	54	132	0.01111111	
GO Cellular Component	spliceosomal snRNP complex	59	1.773867e-9	5.1953257220338986e-8	2.752689	47	0.00771757	73	0.0009391270487671231	1.93179	31	62	0.006378601	
GO Cellular Component	proteasome complex	61	2.284108e-9	6.470391186885245e-8	2.49855	55	0.009031199	103	0.013995628986407766	1.704521	30	68	0.00617284	
GO Cellular Component	endopeptidase complex	62	2.328037e-9	6.488464412903226e-8	2.497139	55	0.009031199	107	0.018000204560747662	1.679817	30	69	0.00617284	
GO Cellular Component	ficolin-1-rich granule lumen	65	3.434659e-9	9.130908849230769e-8	2.002143	87	0.01428571	64	0.00038252385	1.682527	54	124	0.01111111	
GO Cellular Component	U2 snRNP	72	1.149428e-8	2.7586272e-7	4.51234	22	0.003612479	65	0.0004669239433846154	2.846849	14	19	0.002880658	
GO Cellular Component	cytosolic large ribosomal subunit	73	1.908334e-8	4.517261852054794e-7	2.45946	50	0.008210181	69	0.0006594090573913044	1.963459	31	61	0.006378601	
GO Cellular Component	histone methyltransferase complex	74	1.981098e-8	4.626131545945946e-7	2.164747	65	0.01067323	86	0.003766113711627907	1.791805	32	69	0.006584362	
GO Molecular Function	structural constituent of ribosome	8	9.725251e-16	5.132501215249999e-13	2.334298	114	0.01871921	21	0.000007632849255238095	1.764845	74	162	0.01522634	
GO Molecular Function	ribonuclease activity	10	3.244258e-14	1.3697257276000001e-11	2.531305	87	0.01428571	29	0.00015847815668965518	1.873251	48	99	0.009876543	
GO Molecular Function	ribonucleoprotein complex binding	13	1.450728e-13	4.711518166153846e-11	2.377926	93	0.01527094	45	0.0012355880026666667	1.713414	51	115	0.01049383	
GO Molecular Function	endoribonuclease activity	26	8.43326e-10	1.3694316815384616e-7	2.685527	51	0.008374384	42	0.0009220405695238096	2.069775	30	56	0.00617284	
GO Molecular Function	thyroid hormone receptor binding	33	3.526517e-8	0.000004511804476969697	3.078199	33	0.005418719	67	0.006553501826865672	2.345745	17	28	0.003497942	
GO Molecular Function	chaperone binding	37	5.213286e-8	0.000005948782024864865	2.008633	73	0.01198686	88	0.042399377427272726	1.606208	37	89	0.007613169	
GO Molecular Function	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	71	0.00000274577	0.0001632766329577465	2.440594	35	0.005747126	68	0.006887118873529412	2.135136	21	38	0.004320988	
GO Molecular Function	mRNA 5'-UTR binding	81	0.000005714422	0.0002978554281975309	2.918978	24	0.003940887	89	0.047128032305617976	2.283025	13	22	0.002674897	
GO Molecular Function	endoribonuclease activity, producing 5'-phosphomonoesters	90	0.000007809509	0.0003663527444222222	2.469902	31	0.005090312	53	0.003403363759245283	2.398084	18	29	0.003703704	
Human Phenotype	Abnormal CNS myelination	11	2.449271e-11	1.485816853e-8	2.101118	99	0.01625616	64	0.0092785374946875	1.607249	52	125	0.01069959	
Human Phenotype	Increased serum lactate	19	7.211609e-10	2.532792992473684e-7	2.237908	73	0.01198686	59	0.007142893432711865	1.699975	44	100	0.009053498	
Human Phenotype	Non-medullary thyroid carcinoma	47	8.166293e-8	0.000011594398550851065	3.874416	23	0.003776683	108	0.03311557808888889	3.090864	8	10	0.001646091	
Human Phenotype	Decreased taste sensation	169	0.0001695504	0.006694732657988165	3.910123	11	0.00180624	87	0.023007437854022986	3.86358	6	6	0.001234568	
Human Phenotype	Paronychia	272	0.001033889	0.0253644900625	3.360894	10	0.001642036	87	0.023007437854022986	3.86358	6	6	0.001234568	
Mouse Phenotype Single KO	impaired placental function	204	0.0000229288	0.0010292108901960783	4.184095	13	0.002134647	135	0.020346318145925926	3.86358	6	6	0.001234568	
Mouse Phenotype Single KO	thin hypoglossal nerve	211	0.00002556076	0.0011092885275829384	2.972562	20	0.003284072	115	0.01281831895478261	2.833292	11	15	0.002263374	
Mouse Phenotype Single KO	embryonic lethality at implantation, complete penetrance	276	0.0001216051	0.004034557611231885	2.395427	24	0.003940887	126	0.015476768957142858	2.458642	14	22	0.002880658	
Mouse Phenotype Single KO	abnormal DNA replication	468	0.002488961	0.04869960657478632	2.104552	19	0.003119869	146	0.02600781802260274	2.351744	14	23	0.002880658	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	24	9.2128e-13	3.6701492e-10	3.878954	41	0.006732348	221	0.014468284916742083	2.189362	17	30	0.003497942	
Mouse Phenotype	early cellular replicative senescence	39	5.394999e-11	1.322604754846154e-8	2.379392	73	0.01198686	121	0.001141142487768595	1.905327	36	73	0.007407407	
Mouse Phenotype	abnormal cellular replicative senescence	43	3.534862e-10	7.859724553953488e-8	2.2206	77	0.01264368	165	0.005508212047090909	1.74781	38	84	0.00781893	
Mouse Phenotype	prenatal lethality prior to heart atrial septation	81	3.217116e-8	0.0000037973884044444447	2.213051	60	0.009852217	310	0.0419836772032258	1.73195	26	58	0.005349794	
Mouse Phenotype	interstitial pneumonia	187	0.000004682657	0.00023941648971657754	2.58279	30	0.004926108	200	0.010180543238999999	2.458642	14	22	0.002880658	
Mouse Phenotype	thin hypoglossal nerve	256	0.00002556076	0.0009546344779687501	2.972562	20	0.003284072	184	0.008364908507608695	2.833292	11	15	0.002263374	
Mouse Phenotype	impaired placental function	266	0.00003068801	0.001103037833120301	4.065421	13	0.002134647	322	0.04852744935093168	3.31164	6	7	0.001234568	
Mouse Phenotype	embryonic lethality at implantation, complete penetrance	329	0.0001216051	0.003533940307294833	2.395427	24	0.003940887	200	0.010180543238999999	2.458642	14	22	0.002880658