# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	71	1.683066e-36	3.119361337183099e-34	2.298428	294	0.01250106	371	0.00000995586885148248	1.3064	103	118	0.008209788	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	103	2.967931e-25	3.791747963980582e-23	2.198906	219	0.009312016	702	0.004047327876210827	1.252633	77	92	0.006137414	
GO Biological Process	cotranslational protein targeting to membrane	110	3.446387e-24	4.122818775727272e-22	2.125222	226	0.009609661	593	0.0011346910280607082	1.267573	83	98	0.006615654	
GO Biological Process	protein targeting to ER	120	3.939658e-22	4.320163301833333e-20	2.034998	228	0.009694702	689	0.003365583273439768	1.244741	84	101	0.006695361	
GO Biological Process	RNA phosphodiester bond hydrolysis, endonucleolytic	176	2.321482e-17	1.7357035021590911e-15	2.034202	175	0.007441109	1003	0.02782347881355932	1.240083	58	70	0.004622987	
GO Biological Process	adherens junction assembly	180	2.765095e-17	2.021438061388889e-15	2.03026	175	0.007441109	886	0.014562098425395032	1.364595	31	34	0.002470907	
GO Biological Process	mRNA cleavage	211	1.395871e-15	8.705339568246445e-14	2.746511	84	0.003571732	913	0.016710488707557505	1.43158	22	23	0.001753547	
GO Biological Process	gene silencing by miRNA	212	1.398622e-15	8.681352310377358e-14	2.051088	152	0.006463135	572	0.0008383697822552447	1.394608	41	44	0.003267974	
GO Biological Process	paraxial mesoderm development	235	3.111394e-14	1.742248240255319e-12	2.104582	129	0.00548516	897	0.015410303920847267	1.496652	17	17	0.001355014	
GO Biological Process	mitotic G2/M transition checkpoint	313	2.384529e-11	1.0024925594568688e-9	2.176736	92	0.003911897	769	0.006616656635370611	1.439089	25	26	0.001992667	
GO Biological Process	DNA replication checkpoint	410	1.345727e-9	4.319127217804878e-8	3.320077	36	0.001530742	958	0.021604454441544886	1.496652	16	16	0.001275307	
GO Cellular Component	endoribonuclease complex	74	9.425567e-12	2.200997267027027e-10	2.313046	84	0.003571732	203	0.03980511842364532	1.341826	26	29	0.002072374	
GO Cellular Component	mitochondrial small ribosomal subunit	146	0.000001244244	0.000014726394739726026	2.048887	55	0.002338634	111	0.0028756052756756757	1.4432	27	28	0.00215208	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	39	1.148313e-13	1.2431224323076924e-11	2.220436	109	0.004634748	144	0.028083773526388894	1.393435	27	29	0.00215208	
GO Molecular Function	DNA polymerase binding	49	4.115385e-12	3.5459500959183677e-10	3.501567	44	0.001870907	150	0.04427034393333334	1.496652	16	16	0.001275307	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	19	7.932945e-21	3.8232619665789475e-18	2.140798	189	0.008036398	717	0.042900072463040444	1.24721	50	60	0.003985334	
Mouse Phenotype Single KO	cervical vertebral transformation	47	9.130082e-15	1.7788119334893618e-12	2.094548	136	0.005782805	577	0.01992428304852686	1.33911	34	38	0.002710027	
Mouse Phenotype Single KO	abnormal facial motor nucleus morphology	140	1.484054e-9	9.70677319857143e-8	2.084945	83	0.003529212	730	0.044227406843835616	1.496652	14	14	0.001115894	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	166	6.676875e-9	3.683141227409638e-7	2.110808	74	0.003146526	559	0.01720767386583184	1.496652	17	17	0.001355014	
Mouse Phenotype	abnormal cellular replicative senescence	16	1.348668e-26	8.059134217499999e-24	2.046196	274	0.01165065	553	0.0012182610639602171	1.282845	72	84	0.005738881	
Mouse Phenotype	early cellular replicative senescence	19	3.640634e-26	1.832005351263158e-23	2.110085	250	0.01063016	501	0.0007432965673053891	1.312134	64	73	0.005101227	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	210	1.793922e-9	8.167470591428572e-8	2.000679	91	0.003869377	1045	0.03333800844401914	1.37692	23	25	0.001833254