# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 9 3.221079e-118 4.709575395666667e-115 4.408152 372 0.02387064 469 0.02314884143283582 1.284195 77 114 0.007796679 GO Biological Process regulation of gene expression, epigenetic 14 1.354232e-103 1.272881349142857e-100 2.672872 638 0.04093943 202 0.00009739054072277228 1.280295 167 248 0.01690968 GO Biological Process chromatin silencing 28 6.633242e-70 3.1173868385e-67 4.170122 232 0.01488706 525 0.035333669533333334 1.293652 66 97 0.006682868 GO Biological Process gene silencing 41 2.336239e-61 7.498187561219512e-59 2.577191 401 0.02573152 367 0.0055056252043596725 1.256955 119 180 0.01204941 GO Biological Process chromatin assembly or disassembly 54 1.1012e-53 2.6834612592592593e-51 2.363704 412 0.02643737 228 0.0002876972947368421 1.313803 123 178 0.01245443 GO Biological Process nucleosome organization 55 1.526646e-53 3.652569948e-51 2.411515 395 0.02534651 258 0.0008849621314728682 1.300873 117 171 0.0118469 GO Biological Process chromatin assembly 58 4.99065e-51 1.1322752301724138e-48 2.42152 373 0.0239348 292 0.0017294990869178082 1.299606 108 158 0.0109356 GO Biological Process nucleosome assembly 65 6.844823e-45 1.3857080901076922e-42 2.406155 331 0.02123973 337 0.0037849516746587537 1.298759 97 142 0.00982179 GO Biological Process DNA packaging 67 8.682805e-43 1.7053288208208956e-40 2.112012 416 0.02669405 374 0.006132836392780749 1.242039 130 199 0.01316322 GO Biological Process regulation of megakaryocyte differentiation 84 7.568828e-38 1.1856929482380952e-35 2.718355 222 0.01424538 356 0.00486352574016854 1.40094 56 76 0.005670312 GO Biological Process retrograde transport, endosome to Golgi 89 7.257274e-35 1.0730165007415729e-32 2.62119 217 0.01392454 286 0.0015629625255244757 1.43213 58 77 0.005872823 GO Biological Process regulation of viral transcription 117 7.66585e-30 8.621788047008546e-28 2.717553 173 0.01110113 481 0.0248938597016632 1.374769 47 65 0.004759012 GO Biological Process regulation of gene silencing 121 1.465786e-28 1.5940725598347108e-26 2.138707 265 0.01700462 352 0.0046259866363636375 1.30622 90 131 0.009113001 GO Biological Process regulation of posttranscriptional gene silencing 142 4.930165e-25 4.568735298239436e-23 2.169298 223 0.01430955 331 0.003551288504199396 1.343103 77 109 0.007796679 GO Biological Process regulation of gene silencing by RNA 142 4.930165e-25 4.568735298239436e-23 2.169298 223 0.01430955 331 0.003551288504199396 1.343103 77 109 0.007796679 GO Biological Process regulation of gene silencing by miRNA 145 5.707205e-25 5.179386937586207e-23 2.184189 219 0.01405287 340 0.003907077392941176 1.345242 75 106 0.007594168 GO Biological Process ATP-dependent chromatin remodeling 187 4.104831e-20 2.8885278678609626e-18 2.209684 169 0.01084446 273 0.001127133421978022 1.438145 59 78 0.005974079 GO Biological Process histone exchange 205 1.791616e-18 1.150042680195122e-16 2.465313 123 0.00789271 480 0.02465802778895833 1.40094 42 57 0.004252734 GO Biological Process chromatin remodeling at centromere 210 3.787517e-18 2.3733302953809527e-16 2.674482 104 0.006673511 396 0.009643642932575759 1.487955 36 46 0.0036452 GO Biological Process CENP-A containing nucleosome assembly 223 4.009998e-17 2.3662584610762333e-15 2.699202 96 0.006160164 529 0.03580581312665406 1.448591 32 42 0.003240178 GO Cellular Component nucleosome 20 4.535358e-83 3.9185493120000002e-81 4.578311 250 0.01604209 136 0.0300305054117647 1.267517 70 105 0.00708789 GO Cellular Component DNA packaging complex 22 1.062032e-71 8.341778618181818e-70 3.86586 260 0.01668378 139 0.032262555625899275 1.2562 74 112 0.007492912 GO Cellular Component protein-DNA complex 34 1.635022e-41 8.309758870588235e-40 2.114778 402 0.02579569 131 0.025640050809160306 1.195357 127 202 0.01285946 GO Cellular Component chromosome, telomeric region 39 2.055551e-37 9.107672123076923e-36 2.304111 299 0.01918634 99 0.0102584064 1.240952 109 167 0.01103686 GO Cellular Component nuclear chromosome, telomeric region 42 3.95265e-35 1.626233142857143e-33 2.453668 247 0.01584959 114 0.019536858947368424 1.253114 87 132 0.008809235 GO Cellular Component methyltransferase complex 61 1.333706e-20 3.7781048655737703e-19 2.118014 191 0.01225616 128 0.0249164235 1.295375 62 91 0.006277845 GO Cellular Component spliceosomal snRNP complex 86 3.573748e-14 7.180740167441861e-13 2.334521 102 0.006545175 75 0.0010976735232000002 1.471955 48 62 0.004860267 GO Cellular Component small nuclear ribonucleoprotein complex 97 1.243709e-12 2.215597063917526e-11 2.115948 111 0.00712269 72 0.0006892977600000001 1.4604 53 69 0.005366545 GO Cellular Component precatalytic spliceosome 144 1.286657e-8 1.5439884e-7 2.611477 46 0.002951745 152 0.048073175999999995 1.49386 22 28 0.002227623 GO Cellular Component spliceosomal tri-snRNP complex 166 2.22666e-7 0.0000023178725783132532 2.334796 47 0.003015914 142 0.0336267218028169 1.507908 23 29 0.002328878 Human Phenotype Increased serum ferritin 1 2.91468e-22 1.9449659640000003e-18 4.897464 59 0.003785934 76 0.004352804924210527 1.806212 19 20 0.001923856 Human Phenotype Abnormality of transition element cation homeostasis 2 4.576537e-20 1.5269615700499999e-16 3.927576 67 0.004299281 149 0.03208825356644295 1.57347 24 29 0.002430134 Human Phenotype Abnormality of iron homeostasis 3 1.582689e-19 3.520427899e-16 4.035535 63 0.004042608 119 0.0193310361302521 1.663616 21 24 0.002126367 Human Phenotype Episodic fever 55 2.937063e-7 0.00003563458436181819 2.086887 59 0.003785934 157 0.03314187103121019 1.701142 17 19 0.001721345 Human Phenotype Laryngomalacia 87 0.000003601916 0.00027627109733333337 2.233372 41 0.002630903 87 0.009468296689655173 1.901276 14 14 0.001417578 Mouse Phenotype Single KO abnormal platelet volume 47 2.072324e-17 4.03750444e-15 2.146509 154 0.00988193 227 0.013348187137444933 1.434296 43 57 0.004353989 Mouse Phenotype Single KO increased circulating interferon-gamma level 57 3.381798e-15 5.432828822105263e-13 2.479093 98 0.006288501 291 0.030622914921649487 1.459119 33 43 0.003341434 Mouse Phenotype Single KO increased mean platelet volume 85 1.099747e-12 1.1847509739999998e-10 2.038873 122 0.007828542 291 0.030622914921649487 1.459119 33 43 0.003341434 Mouse Phenotype Single KO abnormal circulating interleukin-12b level 147 9.281189e-10 5.7814862362585034e-8 2.712978 50 0.003208419 346 0.046202384528901734 1.584397 20 24 0.002025111 Mouse Phenotype early cellular replicative senescence 16 2.695969e-28 1.6110099755625001e-25 2.471059 194 0.01244867 348 0.01015788938362069 1.380378 53 73 0.005366545 Mouse Phenotype abnormal cellular replicative senescence 19 2.100744e-27 1.0571164938947367e-24 2.344128 208 0.01334702 409 0.01707139458997555 1.33542 59 84 0.005974079 Mouse Phenotype increased circulating interferon-gamma level 44 3.022822e-22 6.568454805e-20 2.747824 124 0.007956879 322 0.007750179261801242 1.46252 40 52 0.004050223 Mouse Phenotype increased cellular sensitivity to ultraviolet irradiation 132 5.634481e-13 4.081157033409091e-11 2.661961 72 0.004620123 512 0.03346712272265625 1.521021 24 30 0.002430134 Mouse Phenotype abnormal circulating interleukin-12b level 171 5.194736e-11 2.9044953740350874e-9 2.55691 64 0.004106776 406 0.016872852462561577 1.57347 24 29 0.002430134 Mouse Phenotype increased circulating interleukin-10 level 362 0.000001428926 0.00003774022509944752 2.053764 54 0.003465092 575 0.047021629857391306 1.535646 21 26 0.002126367 Mouse Phenotype abnormal aorta tunica adventitia morphology 634 0.0001910032 0.002880412610725552 2.427752 22 0.001411704 588 0.04999989990816327 1.901276 9 9 0.0009113001