# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	15	1.707395e-60	1.497840720333333e-57	2.874342	329	0.01984797	358	0.0007612849069832402	1.39262	78	113	0.008380789	
GO Biological Process	regulation of DNA-templated transcription in response to stress	18	1.755866e-56	1.2836355941111109e-53	2.672337	346	0.02087355	282	0.00011483499993971631	1.424127	84	119	0.009025465	
GO Biological Process	endoplasmic reticulum unfolded protein response	22	2.942679e-52	1.760123316409091e-49	2.768074	301	0.01815878	345	0.0005588207737681159	1.398102	79	114	0.008488235	
GO Biological Process	cellular response to topologically incorrect protein	30	1.426442e-47	6.256850092666666e-45	2.471488	334	0.02014961	457	0.0030609907190371987	1.320818	91	139	0.009777587	
GO Biological Process	cellular response to unfolded protein	33	4.742171e-46	1.890976611787879e-43	2.530788	309	0.01864141	390	0.001249516893923077	1.367241	82	121	0.008810573	
GO Biological Process	mitochondrial transport	35	6.512158e-46	2.448385346342857e-43	2.001468	510	0.03076737	210	0.000004603695575190477	1.342195	159	239	0.01708392	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	40	1.339589e-43	4.40691291275e-41	2.21593	381	0.02298504	346	0.0005681850828323699	1.34067	103	155	0.01106694	
GO Biological Process	liver regeneration	43	1.216615e-42	3.7231248337209306e-40	3.555566	169	0.01019546	407	0.0015173904786732189	1.671654	29	35	0.003115934	
GO Biological Process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	52	1.335445e-41	3.379446299038462e-39	4.220403	134	0.008083977	833	0.029562127920768306	1.765324	14	16	0.001504244	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	61	2.302614e-39	4.967229119016394e-37	3.69577	148	0.008928571	736	0.020188105126358696	1.666642	19	23	0.002041474	
GO Biological Process	negative regulation of endoplasmic reticulum unfolded protein response	62	3.481681e-39	7.389587141774194e-37	6.943596	79	0.004765927	821	0.028885752053593176	2.017514	9	9	0.0009670141	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	66	1.694444e-38	3.378361908484848e-36	2.770367	219	0.01321187	420	0.0016667756490238096	1.448471	56	78	0.006016976	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	70	4.168292e-38	7.835793489714287e-36	2.46357	267	0.01610763	598	0.01003116511354515	1.352163	63	94	0.006769099	
GO Biological Process	response to topologically incorrect protein	87	1.990846e-35	3.011211783218391e-33	2.046962	369	0.0222611	743	0.020411326931359355	1.232925	110	180	0.01181906	
GO Biological Process	positive regulation of mRNA catabolic process	89	2.692164e-35	3.980470345617978e-33	3.491834	142	0.008566602	814	0.028602153445945945	1.614011	20	25	0.00214892	
GO Biological Process	cellular response to epidermal growth factor stimulus	90	2.841949e-35	4.155245210111111e-33	2.769034	200	0.01206564	862	0.032687902470997676	1.486589	28	38	0.003008488	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	99	4.07119e-34	5.411392849494949e-32	2.51353	229	0.01381515	516	0.005588318726550388	1.339058	75	113	0.008058451	
GO Biological Process	response to epidermal growth factor	102	1.252465e-33	1.6158026406862746e-31	2.642894	206	0.01242761	750	0.02086426122266667	1.489117	31	42	0.003330826	
GO Biological Process	response to unfolded protein	104	3.165278e-33	4.004989730961538e-31	2.054516	342	0.02063224	631	0.013353917948177496	1.260946	100	160	0.0107446	
GO Biological Process	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	126	1.871312e-31	1.9543329053968257e-29	3.295784	136	0.008204633	570	0.008462054243157895	1.627027	25	31	0.00268615	
GO Cellular Component	PRC1 complex	40	1.133518e-25	4.8967977600000005e-24	7.035912	50	0.003016409	136	0.03681591670588236	1.849388	11	12	0.001181906	
GO Cellular Component	nuclear ubiquitin ligase complex	52	2.698816e-20	8.96837316923077e-19	3.052069	95	0.005731178	133	0.03504358015037594	1.462697	29	40	0.003115934	
GO Cellular Component	high-density lipoprotein particle	94	1.157004e-12	2.1269179914893613e-11	3.094096	55	0.00331805	130	0.03413933833846154	1.569177	21	27	0.002256366	
GO Cellular Component	MLL1 complex	113	1.513253e-11	2.3140718442477876e-10	2.637163	64	0.003861004	120	0.01418881104	1.600097	23	29	0.002471258	
GO Cellular Component	ESCRT complex	162	6.856857e-9	7.3139808e-8	2.444563	54	0.003257722	126	0.02190703542857143	1.585189	22	28	0.002363812	
GO Cellular Component	mitochondrial nucleoid	188	7.39652e-8	6.798503489361702e-7	2.004499	72	0.004343629	97	0.006776182762886597	1.537153	32	42	0.003438272	
GO Cellular Component	endoplasmic reticulum chaperone complex	203	3.385892e-7	0.0000028821780177339904	3.569192	23	0.001387548	101	0.007567385916831684	2.017514	11	11	0.001181906	
GO Molecular Function	ribonuclease activity	14	3.387603e-27	1.021604276142857e-24	2.298271	215	0.01297056	103	0.03577178448932039	1.32463	65	99	0.006983991	
GO Molecular Function	protein transporter activity	17	1.557768e-23	3.868762644705883e-21	2.100473	225	0.01357384	86	0.011729118562790698	1.366025	65	96	0.006983991	
GO Molecular Function	unfolded protein binding	32	8.271881e-17	1.0913712994374999e-14	2.051645	165	0.009954151	91	0.020319590564835163	1.33232	70	106	0.007521221	
GO Molecular Function	proteasome binding	85	2.585041e-10	1.2840050708235293e-8	2.974439	46	0.002775097	82	0.011281122214634147	2.017514	12	12	0.001289352	
GO Molecular Function	L-serine transmembrane transporter activity	168	3.183218e-7	0.000007999729997619049	3.362258	25	0.001508205	106	0.03556213701509434	2.017514	10	10	0.00107446	
Human Phenotype	Exercise intolerance	35	1.498005e-12	2.8560535328571424e-10	2.09377	113	0.006817085	79	0.034946078658227846	1.41226	49	70	0.005264854	
Human Phenotype	Abnormality of monocarboxylic acid metabolism	51	1.4731e-11	1.927450254901961e-9	2.889128	55	0.00331805	52	0.01392728246346154	2.017514	13	13	0.001396798	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	61	3.086828e-25	4.633784261639344e-23	2.04718	258	0.01556467	138	0.0014452917772463767	1.431784	66	93	0.007091437	
Mouse Phenotype Single KO	abnormal osteoblast differentiation	63	7.908821e-25	1.1495408555079366e-22	2.210817	212	0.01278958	238	0.012687885335294118	1.524344	34	45	0.003653164	
Mouse Phenotype Single KO	pale liver	64	8.7422e-25	1.2508175843749998e-22	2.199572	214	0.01291023	140	0.0015983196842142857	1.462697	58	80	0.006231868	
Mouse Phenotype Single KO	decreased sensitivity to induced cell death	77	9.827932e-23	1.1687580951168831e-20	2.06062	227	0.0136945	203	0.0061871322931034475	1.422606	55	78	0.00590953	
Mouse Phenotype Single KO	abnormal embryonic hematopoiesis	81	2.231053e-22	2.522191644567901e-20	2.03912	229	0.01381515	281	0.028478208084341636	1.446519	38	53	0.004082948	
Mouse Phenotype	extramedullary hematopoiesis	2	1.433667e-61	6.8536450935e-58	2.188801	557	0.0336028	475	0.02619158455578947	1.233566	107	175	0.01149672	
Mouse Phenotype	thick epidermis	42	1.583709e-34	3.605200416428571e-32	2.018274	372	0.02244208	445	0.022370484033707866	1.293278	75	117	0.008058451	
Mouse Phenotype	abnormal cellular replicative senescence	141	3.368353e-20	2.2840300023404254e-18	2.076698	196	0.01182432	120	0.00004044242447	1.537153	64	84	0.006876545	
Mouse Phenotype	early cellular replicative senescence	146	6.647646e-20	4.3532974935616434e-18	2.14355	179	0.01079875	118	0.000040989959712711865	1.575319	57	73	0.006124422	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	149	8.764434e-20	5.6239431861744966e-18	2.471439	132	0.00796332	504	0.03030283069047619	1.585189	22	28	0.002363812	
Mouse Phenotype	increased hepatocyte apoptosis	157	1.864296e-19	1.135320640509554e-17	2.025758	200	0.01206564	384	0.014752941700000001	1.403488	48	69	0.005157408	
Mouse Phenotype	increased liver adenoma incidence	450	8.209857e-10	1.7443209506000003e-8	2.311448	68	0.004102317	349	0.010543300975358168	1.657243	23	28	0.002471258	
Mouse Phenotype	abnormal kidney inner medulla morphology	637	1.1817e-7	0.00000177366306122449	2.087984	63	0.003800676	520	0.03313629316153846	2.017514	9	9	0.0009670141	
Mouse Phenotype	echinocytosis	704	4.384348e-7	0.00000595436807215909	2.981752	29	0.001749517	520	0.03313629316153846	2.017514	9	9	0.0009670141