# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of gene expression, epigenetic 1 2.829964e-35 3.7239496276e-31 2.617812 217 0.04009608 138 5.846318662028985e-7 1.601582 113 248 0.02115313 GO Biological Process negative regulation of gene expression, epigenetic 2 8.702181e-33 5.72559998895e-29 3.88991 114 0.0210643 301 0.0005917313763787375 1.664988 54 114 0.01010857 GO Biological Process DNA replication-dependent nucleosome assembly 12 3.350721e-25 3.6743448032500006e-22 14.33786 31 0.005728012 604 0.01942109794834437 1.977174 18 32 0.003369525 GO Biological Process chromatin silencing 18 7.05239e-24 5.155688889444444e-21 4.037166 78 0.01441242 554 0.014203404177075813 1.558185 43 97 0.00804942 GO Biological Process protein-DNA complex subunit organization 20 1.035546e-23 6.813374907e-21 2.165502 208 0.03843311 155 0.000001915896066064516 1.574709 112 250 0.02096593 GO Biological Process positive regulation of gene expression, epigenetic 22 3.454787e-23 2.0664337333181817e-20 3.887812 79 0.01459719 305 0.0005991637854098361 1.801425 41 80 0.007675028 GO Biological Process nucleosome organization 26 3.880168e-22 1.963812719692308e-19 2.513912 143 0.02642276 273 0.0002670867287545788 1.562211 76 171 0.01422688 GO Biological Process chromatin assembly or disassembly 31 1.36277e-20 5.784738848387098e-18 2.395438 145 0.02679231 258 0.00019908143991860468 1.560017 79 178 0.01478847 GO Biological Process protein-DNA complex assembly 39 5.149516e-19 1.737499513948718e-16 2.096047 177 0.0327051 189 0.000012386288202645501 1.572911 98 219 0.01834519 GO Biological Process chromatin assembly 46 1.046152e-18 2.9926769930434784e-16 2.411516 129 0.02383592 278 0.00032907515987050357 1.579514 71 158 0.0132909 GO Biological Process gene silencing 50 2.265733e-18 5.9629561094e-16 2.387333 129 0.02383592 498 0.008045618704819277 1.425518 73 180 0.01366529 GO Biological Process telomere organization 59 3.00464e-17 6.701365722033898e-15 2.790069 91 0.01681449 349 0.0012756877550143266 1.622296 54 117 0.01010857 GO Biological Process nucleosome assembly 63 8.675189e-17 1.8120128896984126e-14 2.407213 115 0.02124908 317 0.0007122800655835962 1.584214 64 142 0.01198053 GO Biological Process chromatin remodeling 66 1.878589e-16 3.7455079774242424e-14 2.026447 164 0.03030303 275 0.0002885053328909091 1.574192 73 163 0.01366529 GO Biological Process regulation of adaptive immune response 70 5.282953e-16 9.931196932428571e-14 2.18062 134 0.02475979 627 0.023417815164274325 1.448921 54 131 0.01010857 GO Biological Process DNA packaging 84 2.956881e-14 4.632094890357143e-12 2.032072 139 0.02568367 517 0.009957687642940038 1.395392 79 199 0.01478847 GO Biological Process regulation of megakaryocyte differentiation 89 8.342982e-14 1.2335426981797751e-11 2.679711 76 0.01404287 282 0.0003573244789539007 1.849987 40 76 0.007487832 GO Biological Process protein heterotetramerization 101 1.400991e-12 1.8253109474257427e-10 3.679899 43 0.007945307 581 0.016594957587951806 1.837374 23 44 0.004305504 GO Biological Process regulation of viral transcription 111 6.913098e-12 8.195446538918919e-10 2.759198 61 0.01127125 674 0.03467013834718101 1.622296 30 65 0.005615874 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 133 5.406626e-11 5.3493076341353385e-9 2.41204 71 0.01311899 235 0.00008426463642553191 1.7277 58 118 0.01085736 GO Cellular Component nucleosome 18 1.037039e-35 9.955574399999999e-34 5.009681 95 0.01755358 42 0.0000229814496 1.807702 54 105 0.01010857 GO Cellular Component DNA packaging complex 20 7.566171e-31 6.537171744e-29 4.195851 98 0.01810791 41 0.000018171850302439024 1.788872 57 112 0.01067016 GO Cellular Component protein-DNA complex 25 1.151871e-22 7.961732352e-21 2.408557 159 0.02937916 34 7.206954352941177e-7 1.653083 95 202 0.0177836 GO Cellular Component nuclear nucleosome 26 4.796375e-22 3.187744615384616e-20 7.591794 40 0.007390983 64 0.0030348836999999997 2.021111 23 40 0.004305504 GO Cellular Component ribosomal subunit 36 6.196803e-11 2.97446544e-9 2.072096 98 0.01810791 48 0.000201779172 1.538989 81 185 0.01516286 GO Cellular Component PML body 39 1.010267e-9 4.476259938461538e-8 2.075861 85 0.01570584 89 0.02375666049438202 1.521948 42 97 0.007862224 GO Cellular Component SWI/SNF superfamily-type complex 40 1.725978e-9 7.45622496e-8 2.247246 69 0.01274945 90 0.023898623999999997 1.611031 33 72 0.006177462 GO Cellular Component large ribosomal subunit 48 7.878597e-8 0.00000283629492 2.138364 61 0.01127125 95 0.027188806736842104 1.46712 48 115 0.008985399 GO Cellular Component cytosolic large ribosomal subunit 73 0.00001256868 0.0002975161512328767 2.158708 39 0.007206208 68 0.0046810986352941175 1.786299 31 61 0.00580307 GO Cellular Component cytoplasmic stress granule 85 0.00005154413 0.0010478618428235295 2.087208 36 0.006651885 59 0.001292828973559322 2.043591 25 43 0.004679895 GO Cellular Component septin cytoskeleton 93 0.00008596931 0.0015973652438709676 3.664774 13 0.002402069 110 0.044010887563636365 3.012836 6 7 0.001123175 GO Cellular Component cytosolic small ribosomal subunit 96 0.00009321048 0.0016777886400000002 2.222142 29 0.005358463 61 0.0021155286452459016 1.997145 25 44 0.004679895 GO Molecular Function nucleosome binding 8 3.164461e-16 1.6700442927500002e-13 3.049676 74 0.01367332 80 0.003389081729 1.810745 34 66 0.006364657 GO Molecular Function nucleosomal DNA binding 9 1.031993e-13 4.841193828888889e-11 3.477121 51 0.009423503 138 0.049280927869565214 1.757488 23 46 0.004305504 GO Molecular Function chromatin DNA binding 11 3.136712e-12 1.2039270967272726e-9 2.212062 96 0.01773836 75 0.0022309672855999997 1.656094 49 104 0.009172595 GO Molecular Function disordered domain specific binding 49 0.00001832731 0.001579140873877551 2.256651 34 0.006282336 106 0.021124526069811318 2.040954 18 31 0.003369525 GO Molecular Function RNA polymerase core enzyme binding 53 0.00002799646 0.002230208568301887 2.238874 33 0.006097561 99 0.014972022282828281 2.008558 20 35 0.003743916 GO Molecular Function cyclin-dependent protein serine/threonine kinase inhibitor activity 58 0.00004675457 0.003403410250689655 3.897932 13 0.002402069 128 0.0364811145625 2.636232 9 12 0.001684762 GO Molecular Function cyclin-dependent protein serine/threonine kinase regulator activity 59 0.00004955486 0.0035461121850847454 2.390111 27 0.004988914 92 0.007562428043478261 2.181709 18 29 0.003369525 GO Molecular Function RNA polymerase II core binding 91 0.000434194 0.020144693054945057 2.080026 27 0.004988914 101 0.015282465364356436 2.134092 17 28 0.003182329 GO Molecular Function protein phosphatase activator activity 105 0.000600475 0.024144813809523814 2.842599 14 0.002586844 119 0.0320771204184874 3.075604 7 8 0.001310371 Human Phenotype Laryngomalacia 22 0.0000387406 0.011750728354545454 2.980245 19 0.003510717 21 0.04602164732380952 2.761767 11 14 0.002059154 Mouse Phenotype Single KO increased T cell proliferation 70 2.834195e-12 3.7075319450000003e-10 2.166003 101 0.01866223 273 0.007965439505128204 1.555299 50 113 0.00935979 Mouse Phenotype Single KO increased autoantibody level 71 3.049415e-12 3.932886359859155e-10 2.234804 94 0.01736881 84 0.0000074237357870238085 1.898087 54 100 0.01010857 Mouse Phenotype Single KO increased anti-nuclear antigen antibody level 72 4.767821e-12 6.063741235694444e-10 2.337716 84 0.01552106 92 0.000011334604272826086 1.966713 47 84 0.008798203 Mouse Phenotype Single KO abnormal spleen marginal zone morphology 75 9.004e-12 1.0993283733333333e-9 2.1688 96 0.01773836 137 0.00011695293664233575 1.757488 54 108 0.01010857 Mouse Phenotype Single KO abnormal marginal zone B cell morphology 77 1.059457e-11 1.259928279090909e-9 2.299785 84 0.01552106 126 0.00008095536548412699 1.856223 47 89 0.008798203 Mouse Phenotype Single KO abnormal spleen secondary B follicle morphology 81 1.098137e-11 1.2414370998765432e-9 2.150818 97 0.01792313 358 0.026639989460893857 1.516264 44 102 0.008236615 Mouse Phenotype Single KO abnormal cellular replicative senescence 86 1.769065e-11 1.8836428145348835e-9 2.805635 57 0.01053215 423 0.04397290979669031 1.640322 28 60 0.005241483 Mouse Phenotype Single KO abnormal follicular B cell morphology 91 3.345107e-11 3.3660598680219786e-9 2.404713 73 0.01348854 69 0.0000013098292239130437 2.263883 38 59 0.007113441 Mouse Phenotype Single KO abnormal gut-associated lymphoid tissue morphology 98 1.328437e-10 1.2412752662244898e-8 2.12594 89 0.01644494 300 0.012914700095666667 1.628891 38 82 0.007113441 Mouse Phenotype Single KO increased IgG1 level 99 1.858275e-10 1.7188105227272726e-8 2.225944 79 0.01459719 375 0.03039440277333333 1.611031 33 72 0.006177462 Mouse Phenotype Single KO abnormal Peyer's patch morphology 103 3.338114e-10 2.9676805726213593e-8 2.105624 87 0.01607539 312 0.015406714133653843 1.625676 37 80 0.006926245 Mouse Phenotype Single KO decreased B cell apoptosis 125 3.74794e-9 2.7455909263999997e-7 3.747607 29 0.005358463 290 0.011702627054482759 2.875889 9 11 0.001684762 Mouse Phenotype Single KO spleen hyperplasia 131 8.268856e-9 5.779993465038169e-7 2.070574 76 0.01404287 390 0.033581771333333336 1.577233 35 78 0.006551853 Mouse Phenotype Single KO abnormal B cell apoptosis 133 8.756132e-9 6.028563964210527e-7 2.336082 58 0.01071693 118 0.00006210230062966101 2.343317 26 39 0.004867091 Mouse Phenotype Single KO lymph node hyperplasia 147 3.894994e-8 0.000002426289799863946 2.638225 42 0.007760532 266 0.006723695931578947 2.213133 17 27 0.003182329 Mouse Phenotype Single KO decreased T cell apoptosis 173 2.561082e-7 0.000013555969869364163 2.425145 43 0.007945307 285 0.009723182129473684 2.108985 18 30 0.003369525 Mouse Phenotype Single KO abnormal B-2 B cell morphology 177 3.313786e-7 0.00001714369401242938 3.171318 27 0.004988914 388 0.033477873997422684 2.175937 13 21 0.002433545 Mouse Phenotype Single KO increased anti-double stranded DNA antibody level 178 3.441718e-7 0.000017705512205617978 2.271557 48 0.00886918 237 0.003194513724599156 1.887672 29 54 0.005428678 Mouse Phenotype Single KO abnormal transitional stage B cell morphology 179 3.505656e-7 0.00001793368267709497 2.169181 53 0.009793052 225 0.0021357306566222225 1.923289 29 53 0.005428678 Mouse Phenotype Single KO increased circulating interleukin-1 beta level 180 3.995745e-7 0.000020327242758333333 3.418194 24 0.00443459 428 0.044623152137850466 2.050402 14 24 0.002620741 Mouse Phenotype decreased susceptibility to autoimmune disorder 40 7.626e-24 1.82280465e-21 2.331217 179 0.03307465 653 0.022359738211332313 1.343961 78 204 0.01460127 Mouse Phenotype abnormal follicular B cell morphology 54 1.526374e-21 2.7025299655555556e-19 2.630882 128 0.02365115 61 3.8527710919672134e-11 2.218189 65 103 0.01216773 Mouse Phenotype abnormal spleen germinal center morphology 56 4.017548e-21 6.859245790714286e-19 2.412302 147 0.02716186 252 0.00006676590473809524 1.667689 65 137 0.01216773 Mouse Phenotype abnormal B cell activation 57 1.019168e-20 1.7095202189473685e-18 2.044194 206 0.03806356 88 3.3797005063636365e-9 1.766061 103 205 0.01928117 Mouse Phenotype abnormal spleen secondary B follicle morphology 59 3.472832e-20 5.62775368677966e-18 2.337438 149 0.02753141 231 0.00003442807659220779 1.682167 67 140 0.01254212 Mouse Phenotype abnormal marginal zone B cell morphology 66 4.317901e-19 6.255068403181818e-17 2.348151 139 0.02568367 84 2.5819059360714285e-9 1.947145 77 139 0.01441408 Mouse Phenotype abnormal spleen marginal zone morphology 71 1.309284e-18 1.7631076512676056e-16 2.1999 155 0.02864006 80 1.3519074731249999e-9 1.887672 87 162 0.01628604 Mouse Phenotype decreased susceptibility to experimental autoimmune encephalomyelitis 76 1.351969e-17 1.7008125801315789e-15 2.598846 105 0.01940133 609 0.017006098891625614 1.506418 45 105 0.008423811 Mouse Phenotype decreased follicular B cell number 87 2.557441e-16 2.8105394713793106e-14 2.690098 91 0.01681449 113 3.685953335575221e-8 2.169738 50 81 0.00935979 Mouse Phenotype abnormal lymph node B cell domain morphology 88 4.148041e-16 4.5067522728409095e-14 2.930755 78 0.01441242 549 0.013107382142076502 1.726655 28 57 0.005241483 Mouse Phenotype abnormal lymph node cortex morphology 89 5.377475e-16 5.776858255617977e-14 2.805036 83 0.01533629 604 0.01662561340231788 1.650973 31 66 0.00580307 Mouse Phenotype abnormal gut-associated lymphoid tissue morphology 90 6.481657e-16 6.885680286333334e-14 2.298171 119 0.02198817 257 0.00007301620372762646 1.793355 50 98 0.00935979 Mouse Phenotype abnormal Peyer's patch morphology 92 1.253485e-15 1.3026706614130434e-13 2.294676 117 0.02161863 247 0.00006370927835222672 1.812987 49 95 0.009172595 Mouse Phenotype lymph node hyperplasia 97 9.915934e-15 9.773839688041237e-13 3.003158 68 0.01256467 241 0.000049845261858921165 2.236803 28 44 0.005241483 Mouse Phenotype abnormal hypersensitivity reaction 102 2.93764e-14 2.753605494117647e-12 2.009184 143 0.02642276 506 0.009910382748023716 1.414071 70 174 0.01310371 Mouse Phenotype increased T cell proliferation 110 3.113285e-13 2.7060107168181818e-11 2.031173 128 0.02365115 606 0.016912919905940595 1.39752 66 166 0.01235492 Mouse Phenotype decreased marginal zone B cell number 114 5.670403e-13 4.755677463421053e-11 2.228811 101 0.01866223 91 3.844711346373627e-9 2.102093 61 102 0.01141894 Mouse Phenotype increased marginal zone B cell number 119 1.937546e-12 1.5567123786554623e-10 3.163566 52 0.009608278 357 0.0016275398381512605 1.986725 26 46 0.004867091 Mouse Phenotype increased thyroid tumor incidence 120 2.136927e-12 1.70259658725e-10 3.631153 43 0.007945307 792 0.042342518215909085 1.968386 14 25 0.002620741 Mouse Phenotype abnormal cellular replicative senescence 124 4.220165e-12 3.253951416532258e-10 2.466339 76 0.01404287 409 0.003437074305623472 1.673798 40 84 0.007487832