# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process regulation of transforming growth factor beta receptor signaling pathway 13 5.801361e-12 5.872316107615385e-9 3.04305 52 0.03445991 100 0.0017777243163000001 2.553246 24 100 0.01359773 GO Biological Process regulation of cellular response to transforming growth factor beta stimulus 15 7.205716e-12 6.321334456266667e-9 3.024636 52 0.03445991 103 0.002462231592912622 2.503183 24 102 0.01359773 GO Biological Process mammary gland epithelial cell differentiation 34 3.367168e-10 1.3031930503529413e-7 5.219544 23 0.01524188 193 0.036376971416580306 4.38057 7 17 0.003966006 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 97 0.000006574115 0.000891843085412371 4.384818 14 0.009277667 186 0.02819839987580645 3.682567 9 26 0.00509915 GO Biological Process peptidyl-lysine methylation 115 0.00002592068 0.002966001983652174 2.385319 29 0.01921803 180 0.026993159047777777 2.393669 18 80 0.0101983 GO Biological Process foregut morphogenesis 121 0.0000293728 0.0031943526876033056 4.074105 13 0.008614977 135 0.010032840738518518 6.383116 6 10 0.003399433 GO Biological Process negative regulation of transforming growth factor beta receptor signaling pathway 135 0.0000493357 0.004808951676296296 2.480488 25 0.01656726 181 0.027524498545856355 2.540544 16 67 0.009065156 GO Biological Process negative regulation of cellular response to transforming growth factor beta stimulus 140 0.00005788459 0.005440737998642857 2.455146 25 0.01656726 195 0.03633600743384615 2.466905 16 69 0.009065156 GO Biological Process histone lysine methylation 161 0.0001220599 0.009976311950931677 2.387029 24 0.01590457 189 0.031504929678306884 2.503183 16 68 0.009065156 GO Biological Process histone methylation 167 0.0001353494 0.010665046434730539 2.165008 29 0.01921803 184 0.02750106561630435 2.323356 19 87 0.01076487 GO Biological Process negative regulation of pro-B cell differentiation 173 0.0001527109 0.011615738341618496 10.25187 5 0.003313453 219 0.04982704621141552 10.63853 3 3 0.001699717 GO Biological Process positive regulation of epithelial to mesenchymal transition 213 0.0003454533 0.02134187781549296 2.105414 27 0.01789264 196 0.037357259658163264 2.901416 12 44 0.006798867 GO Biological Process embryonic foregut morphogenesis 222 0.0003792112 0.022477658472072073 3.545 11 0.007289596 201 0.04354787085870646 5.910293 5 9 0.002832861 GO Biological Process specification of nephron tubule identity 241 0.0004887051 0.02668410958879668 3.708396 10 0.006626905 177 0.026759391519209037 8.510822 4 5 0.002266289 GO Biological Process regulation of axon extension involved in axon guidance 258 0.0006067322 0.0309456938751938 2.526605 17 0.01126574 174 0.025823274538505747 4.654356 7 16 0.003966006 GO Cellular Component transcription factor AP-1 complex 53 0.001464773 0.04775712724528302 8.398544 4 0.002650762 18 0.034553961599999995 8.510822 4 5 0.002266289 GO Molecular Function ATP-dependent protein binding 59 0.0004307842 0.030826625294915252 6.375362 6 0.003976143 29 0.04665965137931035 6.649079 5 8 0.002832861 Mouse Phenotype Single KO abnormal synaptic bouton morphology 17 1.653914e-7 0.00008908759116470589 11.34227 9 0.005964215 85 0.022449333518823528 5.802833 6 11 0.003399433 Mouse Phenotype Single KO small superior cervical ganglion 56 0.00001419669 0.0023214123273214288 4.088053 14 0.009277667 63 0.014250559447619047 3.656994 11 32 0.006232295 Mouse Phenotype Single KO dilated ureter 69 0.00002509999 0.00333102331057971 3.189202 18 0.01192843 88 0.02174786459431818 4.964646 7 15 0.003966006 Mouse Phenotype Single KO abnormal superior cervical ganglion morphology 82 0.00003255399 0.0036353278832926827 3.011551 19 0.01259112 58 0.01271403665 3.292877 13 42 0.007365439 Mouse Phenotype Single KO reduced sympathetic cervical ganglion size 91 0.00003911626 0.003936127393626374 6.600246 8 0.005301524 128 0.046916740814843746 4.910089 6 13 0.003399433 Mouse Phenotype Single KO lumbar vertebral transformation 96 0.00004460474 0.004254641710208333 3.908225 13 0.008614977 119 0.041494691566386556 3.079574 11 38 0.006232295 Mouse Phenotype Single KO abnormal thymus involution 100 0.00005964089 0.0054613162973 4.839088 10 0.006626905 128 0.046916740814843746 4.910089 6 13 0.003399433 Mouse Phenotype Single KO decreased core body temperature 107 0.0000700813 0.005997518356074766 7.186642 7 0.004638834 85 0.022449333518823528 5.802833 6 11 0.003399433 Mouse Phenotype Single KO subcutaneous edema 111 0.00007805977 0.006439579404414414 3.693536 13 0.008614977 99 0.025082512168686864 3.546176 10 30 0.005665722 Mouse Phenotype Single KO abnormal B cell apoptosis 119 0.0001078323 0.008297650177310925 2.74462 19 0.01259112 137 0.045985544983941605 3.00061 11 39 0.006232295 Mouse Phenotype Single KO abnormal paravertebral ganglion morphology 141 0.0001962415 0.012744563230496454 2.61598 19 0.01259112 95 0.021669298301052634 3.00654 13 46 0.007365439 Mouse Phenotype Single KO increased bone trabecula number 175 0.0003728151 0.019507816404 2.737991 16 0.01060305 89 0.021602731405617977 3.191558 12 40 0.006798867 Mouse Phenotype Single KO double ureter 176 0.0003740779 0.019462678013068183 4.215819 9 0.005964215 85 0.022449333518823528 5.802833 6 11 0.003399433 Mouse Phenotype Single KO cervical vertebral transformation 234 0.001261224 0.04935482123076923 2.880341 12 0.007952286 70 0.015893085421428574 3.359535 12 38 0.006798867 Mouse Phenotype abnormal piriform cortex morphology 7 3.989603e-9 0.000005449227754714285 9.147852 13 0.008614977 210 0.037754645255714286 10.63853 3 3 0.001699717 Mouse Phenotype abnormal colon morphology 28 0.000001217335 0.00041567642625 2.048532 54 0.03578529 200 0.0352221264375 1.914935 27 150 0.01529745 Mouse Phenotype extramedullary hematopoiesis 35 0.000001585561 0.0004331299634571429 2.115133 49 0.03247184 156 0.02547342133076923 1.884539 31 175 0.01756374 Mouse Phenotype abnormal sublingual duct morphology 54 0.000006947676 0.001230124634 7.152389 9 0.005964215 231 0.041350219897402604 7.092351 4 6 0.002266289 Mouse Phenotype spleen hyperplasia 63 0.00001124459 0.0017065003966666666 2.240259 36 0.02385686 214 0.038079153169626165 2.053049 22 114 0.01246459 Mouse Phenotype reduced sympathetic cervical ganglion size 86 0.00003911626 0.004348727463488372 6.600246 8 0.005301524 183 0.03426390198852459 4.910089 6 13 0.003399433 Mouse Phenotype vesicoureteral reflux 99 0.00006350574 0.0061331149509090905 9.127616 6 0.003976143 210 0.037754645255714286 10.63853 3 3 0.001699717 Mouse Phenotype subcutaneous edema 105 0.00007805977 0.007107899628285715 3.693536 13 0.008614977 136 0.01906414891985294 3.546176 10 30 0.005665722 Mouse Phenotype increased core body temperature 111 0.0001068864 0.009206674508108107 5.007505 9 0.005964215 240 0.0488979418125 5.319263 5 10 0.002832861 Mouse Phenotype decreased vascular endothelial cell number 118 0.0001424934 0.011545588113559322 4.343686 10 0.006626905 240 0.0488979418125 5.319263 5 10 0.002832861 Mouse Phenotype dry eyes 132 0.0002222711 0.016099499902272725 3.779975 11 0.007289596 142 0.022990723988028167 4.654356 7 16 0.003966006 Mouse Phenotype abnormal fourth pharyngeal arch artery morphology 136 0.0002347308 0.01650192043235294 2.578082 19 0.01259112 172 0.030482474698255817 3.546176 9 27 0.00509915 Mouse Phenotype abnormal hepatic cord morphology 137 0.0002447289 0.017079219072262772 4.472346 9 0.005964215 127 0.015688042632283464 5.802833 6 11 0.003399433 Mouse Phenotype hydroureter 145 0.0003133076 0.02065885492137931 2.193306 25 0.01656726 146 0.024023171607534248 3.431783 10 31 0.005665722 Mouse Phenotype enhanced spatial learning 208 0.0009849021 0.04527235085625 4.062267 8 0.005301524 240 0.0488979418125 5.319263 5 10 0.002832861