# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to stress	10	1.010319e-72	1.3294787721e-69	5.553611	181	0.009013047	707	0.02185951861810467	1.552918	21	24	0.001984877	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	15	1.850382e-60	1.6232784492e-57	2.675404	371	0.01847426	321	0.0001488364477601246	1.366411	87	113	0.008223062	
GO Biological Process	endoplasmic reticulum unfolded protein response	17	1.292248e-58	1.0002759665882352e-55	2.694712	355	0.01767752	534	0.004997997659737827	1.292153	83	114	0.007844991	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	22	9.13419e-56	5.4634911913636365e-53	2.261126	471	0.02345384	542	0.005610883490590406	1.24806	109	155	0.01030246	
GO Biological Process	liver regeneration	23	8.901227e-55	5.092662873608695e-52	3.664184	211	0.01050692	437	0.0012623546137299772	1.571934	31	35	0.002930057	
GO Biological Process	positive regulation of nuclease activity	25	2.138436e-54	1.1255871729599999e-51	6.254681	121	0.006025296	802	0.03781781745885286	1.656446	14	15	0.001323251	
GO Biological Process	cellular response to unfolded protein	27	1.32688e-53	6.466819970370371e-51	2.501334	370	0.01842446	556	0.006952602617805756	1.27607	87	121	0.008223062	
GO Biological Process	cellular response to topologically incorrect protein	28	2.042379e-53	9.59845187892857e-51	2.412581	395	0.01966936	535	0.005110815401308411	1.26404	99	139	0.009357278	
GO Biological Process	regulation of DNA-templated transcription in response to stress	29	5.075224e-53	2.302926641931035e-50	2.441668	383	0.01907181	322	0.0001490515434689441	1.357172	91	119	0.008601134	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	33	5.116204e-50	2.0401251041212123e-47	2.543741	334	0.01663181	593	0.010240347114333895	1.302752	69	94	0.006521739	
GO Biological Process	mRNA catabolic process	36	3.008382e-49	1.0996471871666666e-46	2.075404	503	0.02504731	360	0.00028953696526111107	1.258166	151	213	0.01427221	
GO Biological Process	response to topologically incorrect protein	41	2.267174e-48	7.276522601463415e-46	2.129165	465	0.02315506	577	0.008161480909532063	1.222615	124	180	0.01172023	
GO Biological Process	nuclear-transcribed mRNA catabolic process	44	2.511823e-47	7.51206337659091e-45	2.112601	463	0.02305547	412	0.0006618724679368932	1.254883	140	198	0.01323251	
GO Biological Process	response to unfolded protein	51	1.204893e-45	3.1088601935294117e-43	2.142101	432	0.0215118	596	0.010375674998154363	1.231242	111	160	0.01049149	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	96	2.128274e-35	2.9172872464583337e-33	2.544646	233	0.01160243	602	0.010903374715448506	1.50586	28	33	0.002646503	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	117	1.305732e-32	1.4685578964102564e-30	3.132994	152	0.007568967	763	0.031749528155963304	1.543273	20	23	0.001890359	
GO Biological Process	regulation of necrotic cell death	131	1.901052e-31	1.909613989923664e-29	4.462718	94	0.004680809	557	0.0070023882078994616	1.577568	24	27	0.002268431	
GO Biological Process	cotranslational protein targeting to membrane	137	1.089218e-30	1.0462058147445257e-28	2.422768	220	0.01095508	634	0.014996797563091482	1.285798	71	98	0.006710775	
GO Biological Process	multi-organism metabolic process	145	2.761547e-30	2.5061515153793103e-28	2.028213	321	0.01598446	378	0.0004267829227777778	1.303908	108	147	0.01020794	
GO Biological Process	protein targeting to ER	147	1.207801e-29	1.0811873033333333e-27	2.351825	225	0.01120406	725	0.025402551057931034	1.265178	72	101	0.006805293	
GO Cellular Component	nuclear ubiquitin ligase complex	49	3.359465e-23	1.1847256163265306e-21	2.996553	113	0.00562693	78	0.0005229289107692307	1.552918	35	40	0.003308129	
GO Cellular Component	large ribosomal subunit	56	2.85599e-20	8.812769142857143e-19	2.012251	213	0.01060651	120	0.0095861808	1.265484	82	115	0.007750473	
GO Cellular Component	cleavage furrow	60	9.794403e-20	2.8207880640000003e-18	2.130923	180	0.008963251	116	0.0087441984	1.399333	41	52	0.003875236	
GO Cellular Component	mitochondrial ribosome	71	8.314123e-17	2.0234935977464786e-15	2.20186	140	0.006971417	103	0.0037025855999999998	1.336293	64	85	0.006049149	
GO Cellular Component	endopeptidase complex	75	1.287802e-16	2.967095808e-15	2.106599	153	0.007618763	161	0.045421370832298136	1.286061	50	69	0.004725898	
GO Cellular Component	PcG protein complex	78	6.109759e-16	1.3535466092307692e-14	2.000067	166	0.008266109	113	0.008161022867256637	1.427527	37	46	0.003497164	
GO Cellular Component	outer mitochondrial membrane protein complex	96	1.128645e-12	2.031561e-11	3.58167	45	0.002240813	150	0.02655219456	1.656446	14	15	0.001323251	
GO Cellular Component	mitochondrial large ribosomal subunit	111	1.198791e-11	1.8662259891891893e-10	2.275629	86	0.004282442	149	0.026408409342281877	1.357172	39	51	0.0036862	
GO Cellular Component	pronucleus	122	8.586338e-11	1.216163283934426e-9	2.847095	52	0.002589384	150	0.02655219456	1.656446	14	15	0.001323251	
GO Cellular Component	anaphase-promoting complex	219	5.892467e-7	0.000004649398619178082	2.379331	42	0.002091425	125	0.011552917248	1.605739	19	21	0.001795841	
GO Cellular Component	DNA-directed RNA polymerase I complex	283	0.000009671499	0.00005905424124381625	2.444728	31	0.001543671	157	0.0422795923566879	1.647995	13	14	0.001228733	
GO Molecular Function	unfolded protein binding	22	5.012415e-25	9.619280059090909e-23	2.20663	215	0.0107061	135	0.04941813471111111	1.255729	75	106	0.007088847	
GO Molecular Function	SUMO transferase activity	32	6.162839e-19	8.131095705625001e-17	3.261414	80	0.003983667	98	0.012436952191836735	1.681355	18	19	0.001701323	
GO Molecular Function	cAMP response element binding	319	0.000002426346	0.000032112955523510976	2.063232	51	0.002539588	115	0.02111518021043478	1.774764	13	13	0.001228733	
GO Molecular Function	insulin-like growth factor I binding	323	0.000002652954	0.0000346773120371517	2.009798	54	0.002688975	127	0.03395039851968504	1.774764	12	12	0.001134216	
GO Molecular Function	RNA polymerase I activity	378	0.00001279684	0.00014293190074074073	2.542019	28	0.001394283	127	0.03395039851968504	1.774764	12	12	0.001134216	
Human Phenotype	Aplasia/hypoplasia of the femur	52	7.065275e-18	9.066650014423076e-16	2.462662	119	0.005925705	150	0.022190363059333335	1.50586	28	33	0.002646503	
Mouse Phenotype Single KO	pale liver	54	3.358187e-34	5.694614510925926e-32	2.30763	272	0.01354447	326	0.026944017458895707	1.308888	59	80	0.00557656	
Mouse Phenotype Single KO	abnormal interscapular fat pad morphology	127	1.342446e-22	9.679352773228346e-21	2.477005	152	0.007568967	373	0.04519426302680964	1.543273	20	23	0.001890359	
Mouse Phenotype Single KO	scoliosis	169	3.157738e-20	1.710970820473373e-18	2.083531	195	0.009710188	320	0.0250720119396875	1.470518	29	35	0.002741021	
Mouse Phenotype Single KO	abnormal pharyngeal muscle morphology	263	3.835091e-15	1.3352824443726237e-13	3.635556	54	0.002688975	371	0.04475559029919137	1.774764	11	11	0.001039698	
Mouse Phenotype	extramedullary hematopoiesis	10	1.005191e-68	9.610631151e-66	2.137515	659	0.03281546	468	0.011993191737179488	1.216981	120	175	0.01134216	
Mouse Phenotype	thick epidermis	48	1.839091e-42	3.663239385625e-40	2.033133	454	0.02260731	440	0.008724084383863637	1.274189	84	117	0.007939509	
Mouse Phenotype	decreased circulating free fatty acid level	49	1.001072e-41	1.9533162024489796e-39	2.073486	425	0.02116323	396	0.005775182015151516	1.282602	86	119	0.008128544	
Mouse Phenotype	abnormal vitelline vein morphology	168	3.184209e-24	1.81215608625e-22	2.508118	160	0.007967334	697	0.046999310853658535	1.490802	21	25	0.001984877	
Mouse Phenotype	abnormal thymus development	222	2.958917e-21	1.2743335782432432e-19	2.248672	173	0.00861468	651	0.03796458675115208	1.46877	24	29	0.002268431	
Mouse Phenotype	absent segment of posterior cerebral artery	286	5.885618e-18	1.9675662132167833e-16	2.878711	91	0.004531421	665	0.04126448524060151	1.53275	19	22	0.001795841	
Mouse Phenotype	abnormal vertebral transverse process morphology	316	7.983058e-17	2.4153803018354432e-15	2.937676	82	0.004083259	596	0.029088748947986576	1.774764	11	11	0.001039698	
Mouse Phenotype	abnormal infrahyoid muscle morphology	361	4.864102e-15	1.288245961828255e-13	3.723592	52	0.002589384	688	0.0447406995	1.774764	10	10	0.0009451796	
Mouse Phenotype	poikilocytosis	467	1.98797e-12	4.070017381156317e-11	2.238751	96	0.0047804	628	0.03323788780414013	1.41071	31	39	0.002930057	
Mouse Phenotype	decreased abdominal adipose tissue amount	571	1.771093e-10	2.9655727098073554e-9	2.351281	71	0.003535504	697	0.046999310853658535	1.490802	21	25	0.001984877	
Mouse Phenotype	abnormal neck morphology	1574	0.0005087801	0.0030904997052731897	2.001012	29	0.001444079	688	0.0447406995	1.774764	10	10	0.0009451796