# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	platelet-derived growth factor receptor signaling pathway	38	4.317977e-20	1.4952699827105265e-17	3.132647	90	0.01428345	284	0.01150240236971831	2.104945	19	33	0.003699377	
GO Biological Process	nuclear-transcribed mRNA catabolic process	41	7.491476e-20	2.4043983581463417e-17	2.268603	156	0.02475797	260	0.007494030255384616	1.440226	78	198	0.01518692	
GO Biological Process	mitochondrial transport	48	2.881567e-19	7.899695865208334e-17	2.023508	196	0.03110617	247	0.005790050568016195	1.407314	92	239	0.01791277	
GO Biological Process	RNA catabolic process	50	3.526221e-19	9.2803084278e-17	2.072628	184	0.02920171	216	0.0031553947823611114	1.425975	94	241	0.01830218	
GO Biological Process	mRNA catabolic process	56	1.952365e-18	4.587709113392856e-16	2.143482	163	0.02586891	283	0.011537057928621907	1.407458	82	213	0.01596573	
GO Biological Process	negative regulation of cellular amide metabolic process	58	2.488413e-18	5.645694252931035e-16	2.088743	172	0.02729725	78	0.0000021390410003846155	1.780499	75	154	0.0146028	
GO Biological Process	rRNA metabolic process	67	1.890564e-17	3.7131241307462694e-15	2.042619	172	0.02729725	303	0.016489477756435642	1.355104	96	259	0.01869159	
GO Biological Process	rRNA processing	74	4.501088e-17	8.004029323243243e-15	2.047347	167	0.02650373	322	0.022399020947826087	1.349223	93	252	0.01810748	
GO Biological Process	negative regulation of translation	76	7.10198e-17	1.2296704581578948e-14	2.072982	160	0.02539279	96	0.000010389983156770835	1.764064	69	143	0.01343458	
GO Biological Process	protein targeting to ER	79	1.485585e-16	2.4745332930379743e-14	2.831646	85	0.01348992	386	0.04683332417875648	1.520299	42	101	0.00817757	
GO Biological Process	erythrocyte homeostasis	89	3.449721e-15	5.100548161685393e-13	2.432807	101	0.0160292	371	0.039557301822102424	1.614319	34	77	0.006619938	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	90	3.920379e-15	5.732029695666667e-13	2.598762	89	0.01412474	353	0.03304717337365439	1.53202	44	105	0.008566978	
GO Biological Process	gene silencing by miRNA	93	8.748426e-15	1.237855244451613e-12	3.173015	63	0.009998413	138	0.00022513723564492754	2.243429	27	44	0.005257009	
GO Biological Process	protein import into mitochondrial matrix	96	1.485962e-14	2.0368514539583337e-12	6.396767	29	0.004602444	389	0.047852246825192804	2.36562	11	17	0.002141745	
GO Biological Process	mRNA transport	126	1.169812e-12	1.221710802222222e-10	2.051626	119	0.01888589	169	0.0010138861558579883	1.602612	64	146	0.01246106	
GO Biological Process	posttranscriptional gene silencing	133	1.822309e-12	1.8029897842857143e-10	2.74588	65	0.01031582	172	0.0011041303768604652	2.0389	29	52	0.005646417	
GO Biological Process	mitochondrial transmembrane transport	138	2.385452e-12	2.274649483188406e-10	2.534598	74	0.01174417	376	0.042085211792553194	1.585717	36	83	0.007009346	
GO Biological Process	posttranscriptional gene silencing by RNA	144	2.986819e-12	2.729413279236111e-10	2.73871	64	0.01015712	191	0.002059249154188482	2.007193	28	51	0.005451713	
GO Biological Process	mRNA export from nucleus	145	3.52186e-12	3.196148671724138e-10	2.396976	81	0.0128551	289	0.012237423777854672	1.586548	46	106	0.008956386	
GO Biological Process	RNA 3'-end processing	154	1.253913e-11	1.0714442316233765e-9	2.378164	78	0.01237899	338	0.02769761603372781	1.537552	45	107	0.008761682	
GO Cellular Component	Bcl-2 family protein complex	87	0.000001869549	0.00003713311117241379	4.589897	15	0.002380575	80	0.0483847776	3.133678	6	7	0.001168224	
GO Cellular Component	cytoplasmic stress granule	109	0.000005730498	0.00009084679398165139	2.141312	43	0.006824314	79	0.047274952101265824	1.785468	21	43	0.004088785	
GO Cellular Component	exocyst	111	0.000006911709	0.00010759849686486485	2.369834	34	0.005395969	46	0.003256153794782609	2.559171	14	20	0.002725857	
GO Cellular Component	Cul4-RING E3 ubiquitin ligase complex	188	0.0004104464	0.0037726137191489363	2.159121	25	0.003967624	75	0.04104076032	1.942228	17	32	0.003309969	
GO Cellular Component	intermediate-density lipoprotein particle	198	0.0005563797	0.004855677381818182	3.388381	11	0.001745755	70	0.03774203794285714	3.655958	5	5	0.0009735202	
GO Cellular Component	nuclear lamina	223	0.00176412	0.013669952286995517	2.35834	16	0.002539279	83	0.04963638361445784	2.843523	7	9	0.001362928	
GO Cellular Component	FHF complex	254	0.003420619	0.02327098280314961	3.318513	8	0.00126964	70	0.03774203794285714	3.655958	5	5	0.0009735202	
GO Molecular Function	ribonuclease activity	50	2.279907e-8	0.0000019251534708	2.052843	73	0.01158546	36	0.009865158037777778	1.661799	45	99	0.008761682	
GO Molecular Function	endoribonuclease activity	91	0.000003399551	0.00015772422331868132	2.188445	43	0.006824314	43	0.025375594604651164	1.827979	28	56	0.005451713	
GO Molecular Function	retinoic acid receptor binding	96	0.000005091468	0.00022391851975000002	2.337479	36	0.005713379	39	0.014987905138461537	2.339813	16	25	0.003115265	
GO Molecular Function	porin activity	162	0.000105799	0.0027573048024691358	5.022279	9	0.001428345	46	0.038355832856521735	3.655958	6	6	0.001168224	
Human Phenotype	Abnormal CNS myelination	7	7.033773e-11	6.705195318428571e-8	2.051271	100	0.0158705	13	0.049198119495384614	1.579374	54	125	0.01051402	
Mouse Phenotype Single KO	abnormal vitelline vein morphology	46	1.166177e-15	2.3214527802173917e-13	3.247422	65	0.01031582	136	0.04141416190735294	2.193575	15	25	0.002920561	
Mouse Phenotype Single KO	delayed limb development	81	1.061188e-11	1.1996664834567901e-9	11.6019	15	0.002380575	121	0.031625606577685955	3.655958	6	6	0.001168224	
Mouse Phenotype Single KO	thin myocardium compact layer	141	5.879427e-9	3.8182917048936167e-7	2.254624	64	0.01015712	140	0.044653783464285716	1.984663	19	35	0.003699377	
Mouse Phenotype Single KO	abnormal sublingual gland morphology	175	5.216552e-8	0.0000027295980950857143	4.510892	20	0.003174099	141	0.04514956914326241	3.198963	7	8	0.001362928	
Mouse Phenotype Single KO	decreased circulating noradrenaline level	424	0.000131289	0.0028354088985849063	2.435781	23	0.003650214	141	0.04514956914326241	3.198963	7	8	0.001362928	
Mouse Phenotype Single KO	increased incidence of tumors by UV-induction	762	0.003584436	0.04307438379527559	3.292392	8	0.00126964	141	0.04514956914326241	3.198963	7	8	0.001362928	
Mouse Phenotype	abnormal vitelline vein morphology	54	1.166177e-15	2.064781166111111e-13	3.247422	65	0.01031582	224	0.026253660875892853	2.193575	15	25	0.002920561	
Mouse Phenotype	abnormal brown adipose tissue physiology	69	3.479238e-14	4.82101369826087e-12	3.759728	48	0.007617838	261	0.042622388517241386	2.309026	12	19	0.002336449	
Mouse Phenotype	decreased hepatocyte proliferation	166	4.170458e-9	2.4020330685542167e-7	2.388214	58	0.009204888	178	0.013915648762921347	2.020398	21	38	0.004088785	
Mouse Phenotype	thin ventricle myocardium compact layer	242	1.864066e-7	0.000007364601250413222	2.426458	44	0.006983019	261	0.042622388517241386	2.309026	12	19	0.002336449	
Mouse Phenotype	abnormal sublingual gland morphology	271	6.188842e-7	0.000021834508620664206	3.236575	25	0.003967624	137	0.006067585070802919	3.046632	10	12	0.00194704	
Mouse Phenotype	decreased circulating noradrenaline level	735	0.001158236	0.015066522987755102	2.035716	24	0.003808919	238	0.032382729380672264	2.924766	8	10	0.001557632