# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	56	3.40752e-22	8.007063514285714e-20	2.283877	175	0.01242192	390	0.0001359916180179487	1.351051	91	118	0.00849039	
GO Biological Process	viral gene expression	67	2.230782e-19	4.3813224385074625e-17	2.115709	179	0.01270585	319	0.00002566390694827586	1.365664	99	127	0.009236798	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	69	6.935111e-19	1.3225960238985505e-16	2.014787	196	0.01391255	600	0.0048715012770000005	1.286803	83	113	0.007743982	
GO Biological Process	viral transcription	87	3.562123e-16	5.3878133973563215e-14	2.040869	160	0.01135718	413	0.00023462716847699757	1.348818	87	113	0.008117186	
GO Biological Process	cotranslational protein targeting to membrane	88	4.430106e-16	6.624518733409091e-14	2.166337	138	0.009795571	503	0.001172625697475149	1.340749	75	98	0.006997574	
GO Biological Process	snRNA metabolic process	93	9.242694e-16	1.3077915090967743e-13	2.218283	128	0.009085747	619	0.005742234709208402	1.32412	65	86	0.006064564	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	94	1.124393e-15	1.574030583723404e-13	2.113547	142	0.0100795	785	0.019323262307006366	1.302704	58	78	0.005411457	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	97	2.011714e-15	2.7290870645360826e-13	2.178999	130	0.009227712	616	0.0056365807467532465	1.313935	69	92	0.006437768	
GO Biological Process	protein targeting to ER	103	2.086525e-14	2.665687618932039e-12	2.056171	138	0.009795571	610	0.005364216734098361	1.300925	75	101	0.006997574	
GO Biological Process	mitochondrial translational elongation	123	1.31547e-12	1.4073390024390244e-10	2.121709	110	0.007808064	576	0.0033964726883680555	1.339698	65	85	0.006064564	
GO Biological Process	mitochondrial translational termination	124	1.62324e-12	1.7225979967741936e-10	2.106081	111	0.007879046	596	0.004438192893456375	1.329037	66	87	0.006157865	
GO Biological Process	termination of RNA polymerase II transcription	134	4.347315e-12	4.269128215298507e-10	2.215649	95	0.006743328	589	0.004151170758234295	1.371062	54	69	0.005038253	
GO Biological Process	gene silencing by miRNA	159	5.800739e-11	4.800749968616352e-9	2.117481	94	0.006672345	565	0.0030069363061946902	1.473199	37	44	0.003452137	
GO Biological Process	heterochromatin organization	181	1.783499e-10	1.2966333337569062e-8	3.100272	44	0.003123225	717	0.012493510645467226	1.751913	13	13	0.001212913	
GO Biological Process	heterochromatin assembly	206	1.07273e-9	6.852453432038836e-8	3.348435	36	0.002555366	972	0.04961912325514404	1.751913	10	10	0.0009330099	
GO Biological Process	cellular component disassembly involved in execution phase of apoptosis	216	4.710895e-9	2.8699383011574073e-7	2.606346	49	0.003478137	698	0.01143228846260745	1.549769	23	26	0.002145923	
GO Biological Process	intracellular protein transmembrane import	218	5.457935e-9	3.2945397552752296e-7	2.073939	78	0.005536627	475	0.0008329957275368421	1.513015	38	44	0.003545438	
GO Biological Process	mRNA cleavage	221	5.726744e-9	3.409874402533937e-7	2.619958	48	0.003407155	901	0.033312176456159824	1.523402	20	23	0.00186602	
GO Biological Process	regulation of mitophagy	229	7.531268e-9	4.32768365117904e-7	2.016823	82	0.005820557	681	0.01010650619030837	1.41644	38	47	0.003545438	
GO Biological Process	apoptotic nuclear changes	234	9.300201e-9	5.229972006794872e-7	2.60861	47	0.003336173	821	0.023621334624847744	1.532924	21	24	0.001959321	
GO Cellular Component	mitochondrial ribosome	43	3.781527e-15	1.5196461990697676e-13	2.376431	106	0.007524134	150	0.009553917311999999	1.298476	63	85	0.005877962	
GO Cellular Component	large ribosomal subunit	44	6.410479e-15	2.517569934545455e-13	2.02	150	0.01064736	92	0.00007414278886956522	1.355828	89	115	0.008303788	
GO Cellular Component	mitochondrial large ribosomal subunit	54	1.167929e-11	3.7373728e-10	2.564895	68	0.004826803	162	0.012535605333333333	1.374049	40	51	0.00373204	
GO Cellular Component	outer mitochondrial membrane protein complex	55	2.235227e-11	7.022676829090909e-10	3.97099	35	0.002484384	180	0.026147519999999997	1.635118	14	15	0.001306214	
GO Cellular Component	nuclear transcriptional repressor complex	83	1.129221e-7	0.000002350956491566265	2.003078	70	0.004968768	123	0.002179373268292683	1.57068	26	29	0.002425826	
GO Cellular Component	anaphase-promoting complex	103	8.579094e-7	0.000014392887798058253	2.664877	33	0.002342419	160	0.011205669599999999	1.585064	19	21	0.001772719	
GO Cellular Component	Sin3 complex	153	0.00007786654	0.0008794338635294118	2.121343	33	0.002342419	143	0.008225995367832167	1.751913	13	13	0.001212913	
GO Molecular Function	rRNA binding	8	9.018485e-19	4.75950545875e-16	3.080122	86	0.006104486	161	0.03250481086956522	1.343133	46	60	0.004291845	
GO Molecular Function	protein transporter activity	9	2.868388e-18	1.3455926817777779e-15	2.032061	185	0.01313174	72	0.000026561481583333333	1.423429	78	96	0.007277477	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	46	4.796299e-7	0.00004402168343043478	2.040394	60	0.004258944	66	0.000005458113321818183	1.751913	29	29	0.002705729	
GO Molecular Function	telomeric DNA binding	54	9.577192e-7	0.0000748794530074074	2.022559	58	0.004116979	134	0.013868885608955222	1.494278	29	34	0.002705729	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase inhibitor activity	57	0.000001543108	0.00011429828028070175	2.994834	26	0.001845542	156	0.032292048192307694	1.751913	12	12	0.001119612	
GO Molecular Function	mRNA 5'-UTR binding	72	0.00000362111	0.00021233786694444445	2.208192	42	0.002981261	107	0.003018027648598131	1.67228	21	22	0.001959321	
Human Phenotype	Exercise intolerance	1	5.9728e-13	3.985649439999999e-9	2.223725	102	0.007240204	155	0.0019602415372903226	1.40153	56	70	0.005224855	
Human Phenotype	Increased muscle lipid content	2	1.307963e-12	4.3640185494999995e-9	3.765068	42	0.002981261	359	0.04896303526740947	1.567501	17	19	0.001586117	
Human Phenotype	Abnormal CSF metabolite level	6	9.063702e-11	1.0080347241e-7	2.148499	89	0.006317433	157	0.0023356872852866245	1.418215	51	63	0.00475835	
Human Phenotype	Increased CSF lactate	8	9.816038e-11	8.18780269675e-8	2.21249	83	0.005891539	142	0.0014069743241549295	1.449859	48	58	0.004478447	
Mouse Phenotype Single KO	increased skin tumor incidence	17	7.251546e-9	0.000003906023924823529	2.028508	81	0.005749574	331	0.013123649178549848	1.433383	36	44	0.003358836	
Mouse Phenotype	decreased cellular sensitivity to ultraviolet irradiation	83	0.000007123772	0.0008206070372530121	2.483833	31	0.002200454	651	0.040001990322580644	1.635118	14	15	0.001306214	
Mouse Phenotype	abnormal central nervous system regeneration	110	0.00002611843	0.0022701664475454544	2.43927	28	0.001987507	618	0.03235346480582524	1.751913	11	11	0.001026311