# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	mRNA catabolic process	20	1.083392e-24	7.128177664e-22	2.045609	251	0.02468772	255	0.00031259612170980396	1.372152	118	213	0.01556523	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	27	7.050177e-22	3.436047375666667e-19	2.336003	164	0.01613062	495	0.01757902834848485	1.380899	63	113	0.008310249	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	28	5.13564e-21	2.413567384285714e-18	2.495573	138	0.01357333	525	0.021175618201523812	1.364367	65	118	0.008574067	
GO Biological Process	nuclear-transcribed mRNA catabolic process	31	6.550144e-21	2.780430480516129e-18	2.000799	222	0.02183535	307	0.0015401525061237787	1.351009	108	198	0.01424614	
GO Biological Process	gene silencing	32	1.763755e-20	7.2528912640625e-18	2.039194	207	0.02035999	353	0.0033016087566005666	1.348507	98	180	0.01292705	
GO Biological Process	negative regulation of gene expression, epigenetic	33	2.272735e-20	9.06270298939394e-18	2.470237	136	0.01337661	531	0.022320114894726933	1.368786	63	114	0.008310249	
GO Biological Process	regulation of DNA-templated transcription in response to stress	43	2.43257e-19	7.444229913953488e-17	2.153268	171	0.01681912	387	0.005296735518087856	1.415343	68	119	0.008969793	
GO Biological Process	protein refolding	51	1.019607e-17	2.6307859829411766e-15	6.416696	36	0.003540868	534	0.02308011469531835	1.887124	16	21	0.00211054	
GO Biological Process	RNA 3'-end processing	52	2.087025e-17	5.281377302884615e-15	2.361967	125	0.01229468	199	0.000009113090217085427	1.620369	70	107	0.00923361	
GO Biological Process	RNA phosphodiester bond hydrolysis	56	3.731152e-17	8.767540922857143e-15	2.116661	156	0.01534376	305	0.0013801599271475408	1.433966	77	133	0.01015697	
GO Biological Process	cotranslational protein targeting to membrane	63	1.176151e-16	2.4566620649206347e-14	2.436247	112	0.01101603	298	0.0010529076703020134	1.516439	60	98	0.007914523	
GO Biological Process	viral gene expression	70	4.147473e-16	7.796656743857142e-14	2.194644	134	0.0131799	340	0.0027125331742058824	1.423701	73	127	0.009629336	
GO Biological Process	positive regulation of gene expression, epigenetic	78	2.618065e-15	4.4168099147435895e-13	2.514863	96	0.009442313	597	0.031581710209380234	1.424189	46	80	0.006067801	
GO Biological Process	mitochondrial translation	79	3.07249e-15	5.117834925316455e-13	2.289228	115	0.0113111	345	0.003118114683768116	1.458332	63	107	0.008310249	
GO Biological Process	DNA-templated transcription, termination	80	3.351726e-15	5.51317030425e-13	2.223965	122	0.01199961	284	0.0007419354641197183	1.499744	66	109	0.008705975	
GO Biological Process	protein targeting to ER	81	3.648345e-15	5.92698417962963e-13	2.312356	112	0.01101603	309	0.0015711935430097086	1.495919	61	101	0.008046432	
GO Biological Process	protein localization to endoplasmic reticulum	84	4.56911e-15	7.157728391666666e-13	2.091083	139	0.01367168	221	0.00004781544149909502	1.538044	77	124	0.01015697	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	87	5.804939e-15	8.780137046091954e-13	2.392254	103	0.01013082	295	0.0010255834655932203	1.53457	57	92	0.007518797	
GO Biological Process	tRNA processing	94	3.424429e-14	4.793836299042553e-12	2.028309	140	0.01377004	197	0.000008171632124873098	1.577993	79	124	0.01042079	
GO Biological Process	translational elongation	95	4.171382e-14	5.778022709263159e-12	2.165654	119	0.01170453	415	0.007606580560481927	1.415343	64	112	0.008442158	
GO Cellular Component	catalytic step 2 spliceosome	27	2.829799e-18	1.81107136e-16	2.351978	133	0.01308154	70	0.00023557661074285712	1.548031	60	96	0.007914523	
GO Cellular Component	ribosomal subunit	29	4.61465e-18	2.7496948965517243e-16	2.03717	181	0.01780269	78	0.0007227351138461538	1.365615	102	185	0.01345469	
GO Cellular Component	nucleosome	36	1.135646e-16	5.4511008e-15	2.666705	95	0.009343956	145	0.031788752772413796	1.344576	57	105	0.007518797	
GO Cellular Component	mitochondrial ribosome	43	1.977686e-14	7.947538158139534e-13	2.609487	84	0.008262024	110	0.014804787665454545	1.427831	49	85	0.006463527	
GO Cellular Component	large ribosomal subunit	44	4.021741e-14	1.5794473745454544e-12	2.183245	117	0.01150782	116	0.018085948137931036	1.356883	63	115	0.008310249	
GO Cellular Component	DNA packaging complex	48	1.019695e-13	3.670902e-12	2.301867	101	0.009934101	131	0.02293583633587786	1.348999	61	112	0.008046432	
GO Cellular Component	PcG protein complex	51	2.623527e-13	8.889126776470587e-12	2.308459	97	0.009540671	90	0.0036623712	1.669182	31	46	0.00408917	
GO Cellular Component	cytoplasmic exosome (RNase complex)	63	1.410076e-9	3.867637028571428e-8	5.635044	20	0.001967149	88	0.0029900840727272726	2.286323	12	13	0.001582905	
GO Cellular Component	spliceosomal snRNP complex	66	3.072616e-9	8.044667345454546e-8	2.280327	65	0.006393233	129	0.021943684465116277	1.47812	37	62	0.004880623	
GO Cellular Component	endopeptidase complex	71	9.502587e-9	2.3127423008450705e-7	2.066893	76	0.007475165	141	0.028437622468085105	1.435855	40	69	0.005276349	
GO Cellular Component	proteasome complex	76	1.950535e-8	4.434900631578948e-7	2.04085	75	0.007376807	155	0.03793258776774194	1.420546	39	68	0.00514444	
GO Cellular Component	exosome (RNase complex)	126	0.000005691713	0.00007805777828571428	2.55776	30	0.002950723	114	0.01749010357894737	1.830715	17	23	0.002242448	
GO Cellular Component	zonula adherens	154	0.0000511567	0.0005740180363636363	3.02416	18	0.001770434	106	0.011483738626415094	2.47685	8	8	0.00105527	
GO Cellular Component	U1 snRNP	184	0.0001992167	0.0018709046608695653	2.270882	25	0.002458936	154	0.0379932667012987	1.825047	14	19	0.001846722	
GO Cellular Component	nucleotide-activated protein kinase complex	197	0.0003059159	0.0026833638335025385	2.695629	17	0.001672076	134	0.023344119402985076	2.229165	9	10	0.001187178	
GO Cellular Component	HOPS complex	258	0.002494149	0.01670499795348837	2.104766	19	0.001868791	165	0.04446762938181818	1.946096	11	14	0.001450996	
GO Molecular Function	ribonuclease activity	9	2.923786e-15	1.3715804991111112e-12	2.195938	126	0.01239304	87	0.004095966020689656	1.476103	59	99	0.007782614	
GO Molecular Function	ribonucleoprotein complex binding	12	2.496188e-14	8.782421446666667e-12	2.067634	135	0.01327825	76	0.001995752177105263	1.464572	68	115	0.008969793	
GO Molecular Function	endoribonuclease activity	20	9.811036e-11	2.0711096996e-8	2.334079	74	0.00727845	120	0.023588007905	1.548031	35	56	0.004616805	
GO Molecular Function	aminoacyl-tRNA editing activity	45	2.288995e-7	0.000021475859755555557	3.651329	23	0.002262221	130	0.046657192092307696	2.095796	11	13	0.001450996	
GO Molecular Function	proteasome binding	70	0.000002476905	0.00014939275585714286	2.846413	27	0.002655651	113	0.013071969585840709	2.270446	11	12	0.001450996	
GO Molecular Function	2-acylglycerol-3-phosphate O-acyltransferase activity	286	0.001809697	0.02671517739160839	2.352804	16	0.001573719	107	0.011215190588785047	2.47685	9	9	0.001187178	
Human Phenotype	Increased serum lactate	7	5.292449e-13	5.045216025285714e-10	2.111746	115	0.0113111	44	0.0015029494771818183	1.535647	62	100	0.008178341	
Human Phenotype	Dysphonia	11	6.214841e-10	3.770148544818182e-7	2.813996	48	0.004721157	99	0.01659907401919192	1.938404	18	23	0.002374357	
Human Phenotype	Increased CSF lactate	15	2.529671e-9	0.0000011253663055333334	2.327021	63	0.006196518	56	0.0037516511621428572	1.665468	39	58	0.00514444	
Human Phenotype	Abnormal CSF metabolite level	16	3.455294e-9	0.000001441073553875	2.241178	67	0.006589948	50	0.0028951224226	1.651233	42	63	0.005540166	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	167	0.00003241505	0.001777392891317365	2.2233	33	0.003245795	147	0.007739384273469389	1.96084	19	24	0.002506266	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	73	3.537436e-8	0.000004633071999452054	2.550162	45	0.004426084	211	0.002625475975165877	1.898918	23	30	0.003033901	
Mouse Phenotype	abnormal cardiac neural crest cell morphology	280	0.0001274454	0.004351805247857143	2.217104	28	0.002754008	339	0.019867766461061948	2.47685	8	8	0.00105527