# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of cell death 1 6.427814e-84 8.458360442600001e-80 2.192179 681 0.2054919 35 1.2639524036857145e-9 1.603895 197 924 0.07892628 GO Biological Process negative regulation of apoptotic process 3 2.357051e-74 1.0338811369666666e-70 2.189412 612 0.1846711 88 0.0000010056957153636363 1.524412 169 834 0.06770833 GO Biological Process negative regulation of programmed cell death 4 4.344077e-74 1.4290927310750001e-70 2.176606 617 0.1861798 83 6.05090772626506e-7 1.529466 172 846 0.06891026 GO Biological Process negative regulation of MAPK cascade 36 3.807206e-52 1.3916395487222224e-49 3.633733 198 0.05974653 492 0.02138865732215447 1.72091 35 153 0.01402244 GO Biological Process negative regulation of intracellular signal transduction 40 1.649996e-48 5.428074341e-46 2.27766 379 0.1143633 152 0.00007146353359605263 1.586968 104 493 0.04166667 GO Biological Process negative regulation of protein phosphorylation 51 3.613382e-45 9.32323406627451e-43 2.247511 363 0.1095353 130 0.0000211359858 1.688051 92 410 0.03685897 GO Biological Process negative regulation of protein modification process 53 2.112596e-44 5.245217125283019e-42 2.061734 428 0.1291491 288 0.001815570075486111 1.425897 116 612 0.04647436 GO Biological Process negative regulation of phosphorylation 60 2.469428e-42 5.415867175333334e-40 2.145271 375 0.1131563 114 0.000008428686943771929 1.682961 100 447 0.0400641 GO Biological Process cellular response to corticosteroid stimulus 63 2.638533e-41 5.5111834519047616e-39 4.628287 119 0.03590827 286 0.0016938375225174825 2.507612 21 63 0.008413462 GO Biological Process response to corticosteroid 65 7.540554e-41 1.5265561551692307e-38 3.132723 188 0.05672903 298 0.0023618466476174496 1.869028 40 161 0.01602564 GO Biological Process cellular response to glucocorticoid stimulus 74 3.648887e-39 6.4886086531081086e-37 4.53596 115 0.03470127 303 0.0024331069172277226 2.507612 20 60 0.008012821 GO Biological Process response to glucocorticoid 78 2.970884e-37 5.012033661025641e-35 3.108655 173 0.05220278 357 0.005353888432773109 1.854946 36 146 0.01442308 GO Biological Process peptidyl-threonine dephosphorylation 84 2.190184e-36 3.4310275304761905e-34 10.36413 55 0.01659626 412 0.009967453828398058 4.388321 7 12 0.002804487 GO Biological Process response to decreased oxygen levels 90 2.836319e-35 4.1470135245555555e-33 2.400187 250 0.07543754 120 0.000012871563576666665 1.77653 81 343 0.03245192 GO Biological Process positive regulation of kidney development 91 7.540476e-35 1.0903859745494505e-32 4.71084 98 0.02957151 427 0.012490793992505855 2.632993 14 40 0.005608974 GO Biological Process response to oxygen levels 98 4.533961e-34 6.087999265204082e-32 2.332364 255 0.07694629 125 0.0000150720448928 1.742346 85 367 0.03405449 GO Biological Process cellular response to decreased oxygen levels 101 1.654876e-33 2.156090424158416e-31 2.992707 164 0.04948702 207 0.0003965364845024155 1.900506 48 190 0.01923077 GO Biological Process response to hypoxia 105 7.070417e-33 8.860915933619046e-31 2.357011 241 0.07272179 149 0.00006622751601744966 1.72913 77 335 0.03084936 GO Biological Process regulation of hemopoiesis 109 9.624032e-33 1.161859055853211e-30 2.138171 293 0.08841279 615 0.04635907141300813 1.364687 80 441 0.03205128 GO Biological Process actin cytoskeleton reorganization 111 1.175223e-32 1.3932215727027028e-30 3.856965 114 0.03439952 262 0.0012084301456488549 2.639592 20 57 0.008012821 GO Cellular Component focal adhesion 21 1.490043e-29 1.2260925257142856e-27 2.165672 257 0.07754979 13 0.000001652038449230769 1.780213 93 393 0.03725962 GO Cellular Component cell-substrate adherens junction 22 2.416496e-29 1.8980477672727275e-27 2.158417 257 0.07754979 14 0.000002275172434285714 1.766727 93 396 0.03725962 GO Cellular Component cell-substrate junction 23 8.713684e-28 6.546628674782609e-26 2.104753 257 0.07754979 17 0.0000035588515764705882 1.744698 93 401 0.03725962 GO Cellular Component calcium channel complex 32 1.031753e-24 5.571466199999999e-23 3.585218 93 0.02806276 67 0.02757684250746269 2.149382 18 63 0.007211538 GO Cellular Component myelin sheath 42 3.601686e-20 1.4818365257142859e-18 2.7029 113 0.03409777 44 0.0010757279127272727 1.903928 41 162 0.01642628 GO Cellular Component ruffle 77 4.75463e-13 1.0670130701298701e-11 2.12668 112 0.03379602 53 0.004439117886792453 1.811053 39 162 0.015625 GO Cellular Component compact myelin 98 1.096713e-10 1.9337959836734694e-9 4.879099 26 0.007845504 66 0.027752360727272725 3.761418 7 14 0.002804487 GO Cellular Component platelet dense tubular network 114 1.093017e-9 1.6567836631578947e-8 6.469222 18 0.005431503 72 0.033396216 4.103365 6 11 0.002403846 GO Cellular Component cell cortex part 124 4.785146e-9 6.66833249032258e-8 2.028749 82 0.02474351 62 0.019290720309677416 1.783191 32 135 0.01282051 GO Molecular Function protein binding involved in cell adhesion 11 8.763527e-30 3.363600999454546e-27 5.092056 77 0.02323476 26 0.001799091630769231 3.16751 16 38 0.006410256 GO Molecular Function retinal dehydrogenase activity 23 4.220068e-26 7.746576998260869e-24 12.29118 35 0.01056126 79 0.036736215217721524 5.373455 5 7 0.002003205 GO Molecular Function cadherin binding 26 1.049548e-23 1.704304483076923e-21 2.205345 197 0.05944478 15 0.0006177835870666666 1.732232 70 304 0.02804487 GO Molecular Function protein phosphatase activator activity 30 3.588072e-23 5.049613328000001e-21 10.94226 33 0.009957755 49 0.010404765730612244 5.642127 6 8 0.002403846 GO Molecular Function 3',5'-cyclic-AMP phosphodiesterase activity 40 4.726803e-20 4.9891405665e-18 4.843129 53 0.01599276 66 0.029338601236363636 3.761418 8 16 0.003205128 GO Molecular Function phosphoric diester hydrolase activity 47 5.571558e-19 5.004918697021276e-17 2.850872 97 0.02926976 55 0.01911793757818182 2.066713 25 91 0.01001603 GO Molecular Function phosphatase activator activity 65 3.447553e-17 2.2393182716923076e-15 6.587693 34 0.01025951 52 0.0119301054 4.78726 7 11 0.002804487 GO Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity 67 8.228463e-17 5.185159818805969e-15 3.918294 55 0.01659626 82 0.04236554057804878 3.009135 10 25 0.00400641 GO Molecular Function protein binding involved in cell-cell adhesion 71 2.613216e-16 1.5539433735211267e-14 4.134174 50 0.01508751 43 0.00764979172511628 3.154738 13 31 0.005208333 GO Molecular Function 14-3-3 protein binding 98 1.313651e-12 5.659422981632653e-11 3.826685 41 0.01237176 82 0.04236554057804878 3.009135 10 25 0.00400641 GO Molecular Function calcium-dependent phospholipid binding 186 6.176172e-8 0.000001401924633548387 2.46397 46 0.01388051 75 0.034120481424 2.453099 15 46 0.006009615 GO Molecular Function nucleosomal DNA binding 325 0.0001659378 0.0021556596664615386 2.449501 22 0.006638503 75 0.034120481424 2.453099 15 46 0.006009615 Mouse Phenotype Single KO abnormal blood cell morphology/development 7 5.145837e-59 6.731489915571427e-56 2.047351 568 0.1713941 43 0.0000043477372113953495 1.497561 171 859 0.06850962 Mouse Phenotype Single KO neoplasm 10 4.838333e-56 4.430461528100001e-53 2.278987 435 0.1312613 38 0.0000033072842944736838 1.614719 129 601 0.05168269 Mouse Phenotype Single KO abnormal hemopoiesis 14 1.090467e-53 7.132433085e-51 2.081504 502 0.1514786 54 0.000008925541563333334 1.525038 149 735 0.05969551 Mouse Phenotype Single KO abnormal tumor incidence 25 1.282952e-46 4.6991965856e-44 2.239538 377 0.1137598 58 0.000009522834780344826 1.636034 112 515 0.04487179 Mouse Phenotype Single KO altered tumor susceptibility 26 6.096175e-46 2.147025941346154e-43 2.215021 380 0.1146651 49 0.000004963705089591837 1.647859 115 525 0.04607372 Mouse Phenotype Single KO abnormal artery development 52 4.346351e-35 7.653756943653845e-33 2.914227 179 0.05401328 107 0.00048289670564485984 2.186123 34 117 0.01362179 Mouse Phenotype Single KO abnormal placenta labyrinth morphology 60 1.792141e-33 2.7351058561666665e-31 3.002881 163 0.04918527 305 0.015093489104590165 1.747239 36 155 0.01442308 Mouse Phenotype Single KO abnormal skeletal muscle morphology 77 8.904838e-31 1.0589818385194804e-28 2.075981 294 0.08871454 238 0.007860507309243698 1.513092 71 353 0.02844551 Mouse Phenotype Single KO abnormal lymph node B cell domain morphology 79 1.334787e-30 1.547170197341772e-28 5.398275 75 0.02263126 254 0.00954874655433071 2.624245 15 43 0.006009615 Mouse Phenotype Single KO abnormal classified tumor incidence 84 4.099163e-30 4.468575665595239e-28 2.248886 242 0.07302354 187 0.0036331445413368985 1.572957 69 330 0.02764423 Mouse Phenotype Single KO abnormal incidence of induced tumors 85 4.850278e-30 5.225175958352942e-28 2.656698 177 0.05340978 93 0.00013394662675268815 1.926137 53 207 0.02123397 Mouse Phenotype Single KO increased classified tumor incidence 95 1.130148e-29 1.0893437090526317e-27 2.241552 240 0.07242004 204 0.004895552147549019 1.559612 68 328 0.02724359 Mouse Phenotype Single KO increased papilloma incidence 97 1.531126e-29 1.4454145136082474e-27 5.978676 66 0.01991551 78 0.00007738641746666667 3.761418 16 32 0.006410256 Mouse Phenotype Single KO abnormal angiogenesis 100 2.302437e-29 2.1083415609000003e-27 2.022182 298 0.08992154 37 0.000003327213274054054 1.869028 80 322 0.03205128 Mouse Phenotype Single KO decreased T cell proliferation 102 2.776105e-29 2.492234655392157e-27 3.001339 142 0.04284852 359 0.028464037114206128 1.705176 34 150 0.01362179 Mouse Phenotype Single KO abnormal adrenal chromaffin cell morphology 105 4.73823e-29 4.1321878199999995e-27 10.14245 44 0.01327701 379 0.03362017918997361 4.103365 6 11 0.002403846 Mouse Phenotype Single KO abnormal lymph node cortex morphology 109 9.699221e-29 8.148235476788993e-27 5.032587 75 0.02263126 350 0.02615162804457143 2.350886 15 48 0.006009615 Mouse Phenotype Single KO abnormal placenta morphology 110 1.396639e-28 1.1626384839090909e-26 2.192236 242 0.07302354 183 0.003331545775191257 1.59 67 317 0.02684295 Mouse Phenotype Single KO decreased tumor incidence 115 3.762944e-28 2.996285061565217e-26 3.477222 111 0.03349427 258 0.010295520333333334 2.01643 26 97 0.01041667 Mouse Phenotype Single KO abnormal dorsal aorta morphology 116 5.198975e-28 4.104052937499999e-26 3.12115 128 0.03862402 164 0.002070273187134146 2.34478 24 77 0.009615385 Mouse Phenotype abnormal blood cell morphology/development 3 5.795713e-78 1.8470937331e-74 2.059923 721 0.2175619 21 1.0441818507142859e-8 1.512458 230 1144 0.09214744 Mouse Phenotype abnormal hemopoiesis 7 1.116107e-71 1.524442718142857e-68 2.09213 648 0.1955341 27 2.6509515575555554e-8 1.536037 205 1004 0.08213141 Mouse Phenotype abnormal erythroid lineage cell morphology 9 7.650728e-63 8.127623378666667e-60 2.093606 574 0.1732046 232 0.0012588882156465517 1.35242 160 890 0.06410256 Mouse Phenotype gastrointestinal tract polyps 30 6.771855e-49 2.1581901885e-46 6.499713 104 0.03138202 442 0.013439283373303168 2.643159 13 37 0.005208333 Mouse Phenotype abnormal bone marrow cell morphology/development 39 7.092357e-46 1.7387185968461541e-43 2.119239 416 0.1255281 372 0.008542635272580645 1.372409 108 592 0.04326923 Mouse Phenotype abnormal T cell physiology 53 1.546188e-39 2.7892648052830187e-37 2.008694 406 0.1225106 470 0.014664810300638298 1.318658 122 696 0.04887821 Mouse Phenotype abnormal response to injury 55 2.172658e-39 3.776869661454546e-37 2.043276 389 0.1173808 158 0.0001586445232594937 1.507144 117 584 0.046875 Mouse Phenotype abnormal liver lobule morphology 56 3.539078e-39 6.042343706785714e-37 2.977152 194 0.05853953 337 0.005585493643620178 1.636768 52 239 0.02083333 Mouse Phenotype abnormal liver parenchyma morphology 57 1.232034e-38 2.0665749252631577e-36 2.844738 205 0.06185878 318 0.00449200133490566 1.628961 55 254 0.02203526 Mouse Phenotype enlarged spleen 82 2.90203e-34 3.383696198780488e-32 2.06555 331 0.0998793 323 0.004888190012693499 1.41491 101 537 0.04046474 Mouse Phenotype altered tumor pathology 90 6.977342e-33 7.412262984666666e-31 2.421509 229 0.06910078 711 0.047163713742616034 1.428064 56 295 0.0224359 Mouse Phenotype increased myeloid cell number 91 1.74819e-32 1.836752152747253e-30 2.439946 223 0.06729028 680 0.04325179871470588 1.441659 55 287 0.02203526 Mouse Phenotype abnormal tumor necrosis factor level 93 2.870521e-32 2.951080782903226e-30 3.015108 156 0.04707302 561 0.024471370978609623 1.598116 41 193 0.01642628 Mouse Phenotype abnormal T cell proliferation 99 1.287604e-31 1.2435133175757575e-29 2.295278 244 0.07362704 670 0.04020364824626866 1.390089 68 368 0.02724359 Mouse Phenotype abnormal erythrocyte cell number 103 2.712548e-31 2.517929264854369e-29 2.256083 250 0.07543754 321 0.0047607971915887845 1.557275 65 314 0.02604167 Mouse Phenotype abnormal exocrine gland physiology 105 4.415242e-31 4.020393215428571e-29 2.526883 200 0.06035003 174 0.00023664887170689655 1.846514 54 220 0.02163462 Mouse Phenotype abnormal hemoglobin 116 1.995312e-30 1.644584313103448e-28 2.145919 270 0.08147254 541 0.023226761744916825 1.391813 79 427 0.03165064 Mouse Phenotype decreased tumor incidence 118 3.92464e-30 3.179956189830508e-28 2.554634 190 0.05733253 185 0.00036585528267567567 1.828946 53 218 0.02123397 Mouse Phenotype increased type II pneumocyte number 124 1.245932e-29 9.60673859032258e-28 6.88075 59 0.01780326 530 0.022367869301886792 3.077524 9 22 0.003605769 Mouse Phenotype abnormal acute inflammation 125 2.470467e-29 1.88961079896e-27 2.472549 196 0.05914303 451 0.013883629857871399 1.4777 66 336 0.02644231