# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process chromatin assembly 62 1.453358e-16 3.084635148709677e-14 2.310452 123 0.02283698 581 0.04009950450086058 1.395985 61 158 0.01174658 GO Biological Process chromatin assembly or disassembly 66 2.703518e-16 5.3902414184848484e-14 2.207802 133 0.02469365 445 0.01387720343460674 1.421955 70 178 0.01347968 GO Biological Process nucleosome assembly 72 2.174225e-15 3.973698163194444e-13 2.3347 111 0.02060899 498 0.02226959665682731 1.451424 57 142 0.01097631 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 74 3.285675e-15 5.842729368243243e-13 2.527457 94 0.01745266 395 0.007845125957215189 1.567926 49 113 0.009435779 GO Biological Process paraxial mesoderm development 82 7.450567e-14 1.1956342823536586e-11 3.561887 50 0.009283327 401 0.009319663216458853 2.55235 12 17 0.002310803 GO Biological Process regulation of DNA-templated transcription in response to stress 83 1.035742e-13 1.6420878286746986e-11 2.329456 98 0.01819532 360 0.004447339919444445 1.580026 52 119 0.01001348 GO Biological Process nucleosome organization 84 1.106221e-13 1.7329478736904763e-11 2.11976 120 0.02227999 600 0.04417901774333333 1.374438 65 171 0.01251685 GO Biological Process paraxial mesoderm morphogenesis 86 1.723749e-13 2.6375364059302326e-11 3.782208 45 0.008354994 507 0.022692825273175544 2.892663 8 10 0.001540535 GO Biological Process DNA replication-independent nucleosome organization 115 6.98722e-11 7.995202433043478e-9 3.050803 47 0.008726328 424 0.01247120327759434 1.807915 27 54 0.005199307 GO Biological Process DNA replication-independent nucleosome assembly 123 1.271623e-10 1.3604298420325204e-8 3.037121 46 0.008540661 488 0.020014162174385248 1.773803 26 53 0.00500674 GO Biological Process mitotic DNA integrity checkpoint 165 3.804777e-9 3.034367305636364e-7 2.034458 83 0.01541032 311 0.0018909694559485532 1.655847 49 107 0.009435779 GO Biological Process mitotic DNA damage checkpoint 171 5.031422e-9 3.8718410583625733e-7 2.06237 79 0.01466766 331 0.002619307298610272 1.663281 46 100 0.008858078 GO Biological Process purine ribonucleoside biosynthetic process 188 2.491933e-8 0.0000017442205503723404 2.1649 64 0.01188266 514 0.02439013737684825 1.579328 38 87 0.007317543 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 201 4.941495e-8 0.0000032350812291044774 3.317688 29 0.00538433 340 0.0029941326779705886 2.410553 16 24 0.003081071 GO Biological Process placenta blood vessel development 205 6.119926e-8 0.00000392839542604878 2.560041 43 0.007983661 552 0.03049731747101449 1.982874 17 31 0.003273638 GO Biological Process stem cell division 213 8.076613e-8 0.000004989678425680752 2.152239 60 0.01113999 122 1.5648618083606557e-7 2.848835 26 33 0.00500674 GO Biological Process pericyte cell differentiation 240 2.638823e-7 0.000014468446607083332 4.255972 19 0.003527664 489 0.020141273040081797 3.16385 7 8 0.001347968 GO Biological Process labyrinthine layer development 246 3.041318e-7 0.000016268578683739837 2.000624 65 0.01206833 496 0.02203969339012097 1.807915 24 48 0.004621606 GO Biological Process positive regulation of mesonephros development 298 0.000001601168 0.00007070392520805369 2.232088 44 0.008169328 440 0.01355283092590909 2.300982 14 22 0.002695937 GO Biological Process somatic stem cell division 332 0.000003907967 0.00015489439082228917 2.132096 45 0.008354994 205 0.00011921283717073171 2.79405 17 22 0.003273638 GO Molecular Function ATP-dependent protein binding 115 0.000199141 0.007311072191304347 3.572381 12 0.002227999 82 0.03853694344878049 3.16385 7 8 0.001347968 Human Phenotype Nasolacrimal duct obstruction 22 4.551406e-7 0.00013805241926363637 2.494747 39 0.007240995 90 0.04724561851666667 2.410553 12 18 0.002310803 Human Phenotype Duplication of thumb phalanx 265 0.001161064 0.029236905932075473 2.035027 24 0.004455997 36 0.020718979163888887 2.711872 12 16 0.002310803 Mouse Phenotype Single KO abnormal cellular replicative senescence 5 5.675096e-13 1.03933708144e-9 2.967557 60 0.01113999 379 0.030774212583113456 1.687387 28 60 0.005391874 Mouse Phenotype Single KO mesangial cell hyperplasia 28 3.708169e-9 0.0000012127036976071429 3.015858 39 0.007240995 398 0.035606189236180905 2.109234 14 24 0.002695937 Mouse Phenotype Single KO abnormal sternebra morphology 30 4.365668e-9 0.0000013325473958666666 2.018302 84 0.01559599 234 0.005845210506837607 1.918603 26 49 0.00500674 Mouse Phenotype Single KO interrupted aortic arch 48 4.647502e-8 0.000008866078294583332 2.085796 67 0.01243966 161 0.0012662686355279502 2.188528 23 38 0.004429039 Mouse Phenotype Single KO abnormal chromosome number 62 1.753352e-7 0.000025895877845161293 2.117062 59 0.01095433 314 0.018231385779299364 1.698344 31 66 0.005969574 Mouse Phenotype Single KO abnormal ilium morphology 76 4.596948e-7 0.00005538717478421053 2.792176 32 0.005941329 343 0.023341713587463557 2.892663 8 10 0.001540535 Mouse Phenotype Single KO small basisphenoid bone 101 0.000001670182 0.0001514243225148515 2.578796 33 0.006126996 273 0.010512229291575092 2.781407 10 13 0.001925669 Mouse Phenotype Single KO persistent right dorsal aorta 106 0.000001916592 0.00016556823532075474 2.561778 33 0.006126996 336 0.022453350992261905 2.582735 10 14 0.001925669 Mouse Phenotype Single KO heterochrony 111 0.000002156601 0.00017790986808108108 2.936018 26 0.00482733 399 0.03586367737343358 2.339654 11 17 0.002118236 Mouse Phenotype Single KO abnormal CD4-negative NK T cell number 131 0.000004920008 0.00034391231493129766 3.029098 23 0.00427033 443 0.04930598018735892 3.099282 6 7 0.001155402 Mouse Phenotype Single KO abnormal metanephros morphology 144 0.000007773293 0.0004943058611180556 2.181337 40 0.007426662 450 0.049339991586666666 2.169497 12 20 0.002310803 Mouse Phenotype Single KO increased CD4-negative NK T cell number 151 0.00001061082 0.0006434654221192053 3.061448 21 0.003898997 405 0.03653032533333333 3.615829 5 5 0.0009628346 Mouse Phenotype Single KO abnormal thyroid cartilage morphology 169 0.00001448087 0.0007846232342603551 2.195535 37 0.006869662 218 0.0045112086513761475 2.611432 13 18 0.00250337 Mouse Phenotype Single KO abnormal stapedial artery morphology 179 0.00002049518 0.001048460129944134 2.92504 21 0.003898997 272 0.009561059358088236 2.55235 12 17 0.002310803 Mouse Phenotype Single KO delayed intramembranous bone ossification 239 0.00006950729 0.002663088931087866 2.01095 38 0.007055329 422 0.042098938616113746 2.136626 13 22 0.00250337 Mouse Phenotype Single KO decreased podocyte number 240 0.00007088249 0.0027044623372083332 3.342179 15 0.002784998 405 0.03653032533333333 3.615829 5 5 0.0009628346 Mouse Phenotype Single KO decreased molar number 252 0.00007819002 0.0028412143378571428 2.735462 20 0.003713331 329 0.020831963470516718 3.16385 7 8 0.001347968 Mouse Phenotype Single KO absent stapedial artery 289 0.0001252064 0.003967179947404844 2.719413 19 0.003527664 327 0.020590808241284404 2.485882 11 16 0.002118236 Mouse Phenotype Single KO abnormal iris stroma morphology 325 0.0001944173 0.005477782203384615 2.231723 26 0.00482733 200 0.0032400203943 3.254246 9 10 0.001733102 Mouse Phenotype Single KO absent palatal shelf 329 0.000203678 0.005668934486322189 3.825916 11 0.002042332 405 0.03653032533333333 3.615829 5 5 0.0009628346 Mouse Phenotype abnormal cellular replicative senescence 1 2.213709e-18 2.1165271749e-14 2.934764 90 0.01670999 557 0.01567602163357271 1.592687 37 84 0.007124976 Mouse Phenotype early cellular replicative senescence 3 1.367938e-17 4.359618406e-14 3.022093 82 0.01522466 684 0.03021382233333333 1.585021 32 73 0.006162141 Mouse Phenotype absent sternum 17 2.082958e-12 1.1714800845882351e-9 3.200197 51 0.009468994 549 0.015226658773224043 2.892663 8 10 0.001540535 Mouse Phenotype mesangial cell hyperplasia 32 1.409091e-10 4.2100997034375e-8 2.799886 52 0.00965466 783 0.04425067688122605 1.807915 18 36 0.003466205 Mouse Phenotype abnormal third pharyngeal arch artery morphology 43 8.018754e-10 1.7829606277674418e-7 2.861759 46 0.008540661 577 0.017588760259965336 2.23837 13 21 0.00250337 Mouse Phenotype abnormal rib development 47 1.170531e-9 2.3811589129787233e-7 2.865285 45 0.008354994 761 0.03919415735479632 1.8627 17 33 0.003273638 Mouse Phenotype abnormal ureteric bud invasion 48 1.348089e-9 2.685224776875e-7 3.131813 39 0.007240995 367 0.0029119705839237057 2.711872 12 16 0.002310803 Mouse Phenotype abnormal ureteric bud elongation 66 9.700577e-9 0.0000014052608590454545 2.51363 50 0.009283327 224 0.00022338222229017856 2.754917 16 21 0.003081071 Mouse Phenotype decreased B cell apoptosis 67 1.384436e-8 0.0000019756108352238808 2.966526 37 0.006869662 814 0.04982930096314497 2.066188 12 21 0.002310803 Mouse Phenotype fusion of vertebral arches 70 1.80416e-8 0.0000024642248228571424 2.140831 67 0.01243966 379 0.0035916993870712404 1.874874 28 54 0.005391874 Mouse Phenotype midface hypoplasia 77 2.669165e-8 0.0000033142709824675323 3.254547 31 0.005755663 727 0.033640122049518564 2.812311 7 9 0.001347968 Mouse Phenotype abnormal thyroid cartilage morphology 118 1.682845e-7 0.000013635322919491525 2.242995 52 0.00965466 260 0.00045090448234615387 2.503266 18 26 0.003466205 Mouse Phenotype athymia 119 1.776825e-7 0.000014275818340336135 2.593104 39 0.007240995 592 0.019892645670608108 2.086055 15 26 0.002888504 Mouse Phenotype persistent right dorsal aorta 123 2.355494e-7 0.000018309657019512194 2.56346 39 0.007240995 314 0.001218434352611465 2.765046 13 17 0.00250337 Mouse Phenotype abnormal ilium morphology 145 4.596948e-7 0.000030311324019310347 2.792176 32 0.005941329 549 0.015226658773224043 2.892663 8 10 0.001540535 Mouse Phenotype abnormal sublingual gland morphology 148 5.016165e-7 0.00003240510376013513 3.483507 23 0.00427033 552 0.015275769049999999 2.711872 9 12 0.001733102 Mouse Phenotype abnormal fourth pharyngeal arch artery morphology 157 6.471483e-7 0.00003941009488089172 2.090878 55 0.01021166 166 0.00004068511336807229 2.678392 20 27 0.003851338 Mouse Phenotype abnormal thymus development 167 9.752392e-7 0.000055833904138922163 2.229351 46 0.008540661 630 0.02467689547142857 1.99494 16 29 0.003081071 Mouse Phenotype abnormal midface morphology 186 0.000001807752 0.00009292428425806452 2.198639 45 0.008354994 787 0.045317244808132144 2.259893 10 16 0.001925669 Mouse Phenotype heterochrony 191 0.000002156601 0.00010795425215183247 2.936018 26 0.00482733 620 0.024098284606451612 2.339654 11 17 0.002118236