# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of DNA-templated transcription in response to stress	16	4.133629e-22	3.3996515006875003e-19	2.597051	135	0.0202855	303	0.01368919478448845	1.494995	55	119	0.009474591	
GO Biological Process	regulation of necrotic cell death	26	1.214289e-18	6.145703442692308e-16	5.873736	41	0.006160781	224	0.001661126952455357	2.276218	19	27	0.00327304	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	29	4.817604e-18	2.1860293460689656e-15	2.735086	99	0.01487603	192	0.00013485685882291668	1.672137	61	118	0.01050818	
GO Biological Process	IRE1-mediated unfolded protein response	32	1.2517e-17	5.14722509375e-15	3.498311	67	0.01006762	355	0.027939611370704224	1.673082	30	58	0.005167959	
GO Biological Process	rRNA processing	36	3.539049e-17	1.2936207164166668e-14	2.019694	174	0.02614576	132	0.000007345196290757576	1.514626	118	252	0.0203273	
GO Biological Process	mRNA catabolic process	44	2.310263e-16	6.909261549318182e-14	2.029463	163	0.02449286	179	0.00008966344112290503	1.503417	99	213	0.01705426	
GO Biological Process	endoplasmic reticulum unfolded protein response	46	8.416084e-16	2.4075488990434783e-13	2.428001	106	0.01592787	251	0.004051916134422311	1.560565	55	114	0.009474591	
GO Biological Process	nuclear-transcribed mRNA catabolic process	52	1.879223e-15	4.755518357115385e-13	2.051548	149	0.02238918	195	0.00019575949234871794	1.502957	92	198	0.01584841	
GO Biological Process	cellular response to unfolded protein	58	3.797663e-14	8.61611162362069e-12	2.243994	110	0.01652893	247	0.0033585603821862345	1.550482	58	121	0.009991387	
GO Biological Process	cotranslational protein targeting to membrane	62	7.986913e-14	1.69515787366129e-11	2.625278	79	0.01187077	199	0.0002690844895879397	1.716332	52	98	0.008957795	
GO Biological Process	cellular response to topologically incorrect protein	63	8.025021e-14	1.6762103387142855e-11	2.156401	117	0.01758077	329	0.018070586750759877	1.442783	62	139	0.01068045	
GO Biological Process	retrograde transport, endosome to Golgi	66	1.478246e-13	2.9473089566666666e-11	2.460871	87	0.01307288	227	0.0021464543422026433	1.722333	41	77	0.007062877	
GO Biological Process	protein targeting to ER	69	1.546823e-13	2.9499483850724635e-11	2.554856	81	0.0121713	168	0.000057328475901785716	1.76143	55	101	0.009474591	
GO Biological Process	viral gene expression	76	4.8224e-13	8.349731789473683e-11	2.32695	93	0.01397446	184	0.00010388036423369564	1.655517	65	127	0.01119724	
GO Biological Process	multi-organism metabolic process	81	1.058572e-12	1.719722092345679e-10	2.116364	111	0.01667919	166	0.000051516549601204824	1.628315	74	147	0.01274763	
GO Biological Process	protein localization to endoplasmic reticulum	84	1.670356e-12	2.616692214761905e-10	2.229323	97	0.01457551	204	0.0004346343519362745	1.617313	62	124	0.01068045	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	91	6.861983e-12	9.922729043626374e-10	2.322294	84	0.01262209	162	0.00004319975420555556	1.755939	57	105	0.009819121	
GO Biological Process	gene silencing by miRNA	93	7.3018e-12	1.0331654430107528e-9	2.813488	59	0.008865515	262	0.005087877124809161	1.91137	26	44	0.004478898	
GO Biological Process	viral transcription	95	9.212683e-12	1.2761020589157896e-9	2.295173	85	0.01277235	202	0.0003035845140693069	1.66025	58	113	0.009991387	
GO Biological Process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	98	9.831939e-12	1.3201886255204082e-9	4.436836	32	0.004808415	353	0.027499204774220964	2.646512	9	11	0.001550388	
GO Cellular Component	catalytic step 2 spliceosome	36	2.702866e-13	1.2973756799999999e-11	2.404453	89	0.0133734	59	0.00207427392	1.617313	48	96	0.008268734	
GO Cellular Component	large ribosomal subunit	43	4.916365e-11	1.9756927255813953e-9	2.280612	80	0.01202104	45	0.000360789888	1.631376	58	115	0.009991387	
GO Cellular Component	azurophil granule lumen	50	1.572476e-9	5.434477056e-8	2.133011	78	0.01172051	86	0.01554003460465116	1.528449	43	91	0.007407407	
GO Cellular Component	host cell	76	3.173237e-7	0.000007214938863157895	2.094069	58	0.008715252	97	0.03104964816494845	1.569745	33	68	0.005684755	
GO Cellular Component	cleavage furrow	79	4.415356e-7	0.000009657892617721519	2.071964	58	0.008715252	82	0.010172207063414635	1.741721	28	52	0.004823428	
GO Cellular Component	Flemming body	121	0.00002059106	0.0002940607576859504	2.345973	31	0.004658152	106	0.04641129237735849	1.968902	14	23	0.002411714	
GO Cellular Component	Bcl-2 family protein complex	143	0.00006582506	0.0007954245012587413	3.766314	13	0.001953418	73	0.006373339791780822	3.234625	7	7	0.001205857	
GO Cellular Component	endoplasmic reticulum quality control compartment	199	0.0007808252	0.00678023088241206	2.061852	25	0.003756574	67	0.0038139152238805965	2.199545	17	25	0.00292851	
GO Molecular Function	unfolded protein binding	4	8.491122e-22	8.962379271e-19	3.097062	100	0.0150263	42	0.00021215067485714283	1.708859	56	106	0.009646856	
GO Molecular Function	structural constituent of ribosome	11	2.972737e-12	1.1409905103636363e-9	2.079906	111	0.01667919	56	0.001004615852857143	1.517479	76	162	0.01309216	
GO Molecular Function	ribonucleoprotein complex binding	12	7.410661e-12	2.6073175618333337e-9	2.199442	94	0.01412472	59	0.0015487576911864408	1.603249	57	115	0.009819121	
GO Molecular Function	ubiquitin-specific protease binding	32	1.035305e-7	0.000013659555343750001	4.132696	21	0.003155522	61	0.0032934167806557375	2.628133	13	16	0.002239449	
GO Molecular Function	thyroid hormone receptor binding	90	0.00003658388	0.0017161904595555555	2.390066	28	0.004207363	91	0.049249861978021975	1.96388	17	28	0.00292851	
GO Molecular Function	disordered domain specific binding	99	0.00004694609	0.0020020847674747477	2.051062	38	0.005709992	78	0.02475358058717949	1.982512	19	31	0.00327304	
Human Phenotype	Increased serum lactate	15	2.566715e-9	0.0000011418459463333333	2.132073	76	0.01141998	11	0.005324895667909091	1.682005	52	100	0.008957795	
Human Phenotype	Abnormal CSF metabolite level	26	2.395912e-7	0.00006149200298461538	2.350738	46	0.006912096	45	0.045900393617777785	1.694328	33	63	0.005684755	
Human Phenotype	Increased CSF lactate	27	2.553071e-7	0.00006309867697407407	2.426459	43	0.006461307	41	0.04753944481219512	1.728851	31	58	0.005340224	
Mouse Phenotype Single KO	abnormal adrenal medulla morphology	43	2.610218e-8	0.0000055585502851162786	2.998734	35	0.005259204	85	0.040153207995294114	2.336118	13	18	0.002239449