# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	19	3.877731e-56	2.6856348541578946e-53	2.705302	337	0.01868071	338	0.000051647712381656806	1.373418	89	113	0.00826523	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	22	1.913697e-52	1.1446517646818182e-49	2.292617	429	0.02378049	452	0.0011873377345132743	1.27127	113	155	0.01049406	
GO Biological Process	endoplasmic reticulum unfolded protein response	24	5.007731e-52	2.7456971762083336e-49	2.678636	317	0.01757206	495	0.0025556840905858586	1.300185	85	114	0.007893759	
GO Biological Process	regulation of DNA-templated transcription in response to stress	28	2.151625e-49	1.01118690625e-46	2.469662	348	0.01929047	341	0.00005621690734604105	1.362784	93	119	0.008636701	
GO Biological Process	cellular response to topologically incorrect protein	29	4.976043e-49	2.2579224081724138e-46	2.4273	357	0.01978936	355	0.00008630817589014086	1.329787	106	139	0.009843982	
GO Biological Process	response to topologically incorrect protein	31	1.523718e-48	6.467937149032258e-46	2.201965	432	0.02394678	252	8.410089220238095e-7	1.346584	139	180	0.01290862	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	36	3.445149e-47	1.2592976580833334e-44	2.58581	305	0.01690687	617	0.008817553714748785	1.298558	70	94	0.006500743	
GO Biological Process	cellular response to unfolded protein	37	1.355318e-46	4.820170151891892e-44	2.468393	328	0.01818182	409	0.00042487483202933985	1.325848	92	121	0.008543834	
GO Biological Process	response to unfolded protein	39	2.632203e-45	8.881322891538461e-43	2.207936	400	0.02217295	290	0.000007613384479655173	1.340529	123	160	0.01142273	
GO Biological Process	liver regeneration	45	1.90857e-42	5.581082806666667e-40	3.421673	177	0.00981153	727	0.02329979239064649	1.444845	29	35	0.002693165	
GO Biological Process	nuclear-transcribed mRNA catabolic process	55	3.726121e-39	8.914913861636364e-37	2.057131	405	0.02245011	144	1.2647745435416667e-12	1.444341	164	198	0.01523031	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	65	3.7288e-37	7.548812184615385e-35	2.527546	248	0.01374723	192	2.264835241145833e-9	1.492556	101	118	0.009379643	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	67	6.194537e-37	1.216625557955224e-34	2.686793	221	0.01225055	842	0.04275105922090262	1.426727	27	33	0.002507429	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	87	1.249154e-30	1.889381320229885e-28	2.866037	163	0.009035477	555	0.004263454354234235	1.482211	34	40	0.003157504	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	91	3.451095e-30	4.990435066483517e-28	2.452555	211	0.01169623	441	0.0009470108586167801	1.38608	62	78	0.005757801	
GO Biological Process	regulation of necrotic cell death	99	8.501564e-29	1.1300210169292929e-26	4.49222	85	0.004711752	787	0.03405917050063532	1.48544	23	27	0.002135958	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	100	9.387037e-29	1.2352401988300001e-26	2.299464	228	0.01263858	581	0.006203109567125646	1.280828	83	113	0.007708024	
GO Biological Process	translational elongation	109	1.684123e-27	2.0331536290825692e-25	2.276939	222	0.01230599	221	2.2038591976923076e-8	1.479097	95	112	0.008822437	
GO Biological Process	protein targeting to ER	112	9.020375e-27	1.0598135234375e-24	2.350414	202	0.01119734	204	5.123824972990196e-9	1.519331	88	101	0.008172363	
GO Biological Process	cotranslational protein targeting to membrane	113	9.72048e-27	1.1319627992920354e-24	2.39053	195	0.01080931	215	1.725398287255814e-8	1.51246	85	98	0.007893759	
GO Cellular Component	ribosomal subunit	39	2.373251e-29	1.0515327507692307e-27	2.010779	317	0.01757206	41	6.97451988292683e-11	1.4233	151	185	0.01402303	
GO Cellular Component	proteasome core complex	41	6.97819e-29	2.9410517853658534e-27	5.400702	71	0.003935698	140	0.003364292571428571	1.598463	22	24	0.002043091	
GO Cellular Component	mitochondrial ribosome	43	1.30909e-28	5.260715162790698e-27	2.783743	159	0.008813747	65	3.5515318153846154e-7	1.497597	73	85	0.006779346	
GO Cellular Component	endopeptidase complex	47	4.350485e-24	1.5994974638297875e-22	2.482995	162	0.008980044	90	0.0001394634624	1.440512	57	69	0.005293462	
GO Cellular Component	proteasome complex	48	1.032409e-23	3.7166724e-22	2.469062	161	0.008924612	98	0.00018593068408163265	1.436052	56	68	0.005200594	
GO Cellular Component	large ribosomal subunit	50	8.063603e-23	2.7867811968000002e-21	2.155891	205	0.01136364	61	5.122953442622951e-8	1.455675	96	115	0.008915305	
GO Cellular Component	peptidase complex	53	1.579761e-21	5.150616996226415e-20	2.158275	192	0.01064302	93	0.00017503322632258066	1.387096	70	88	0.006500743	
GO Cellular Component	mitochondrial large ribosomal subunit	60	2.721851e-19	7.838930880000001e-18	2.886686	98	0.005432373	79	0.00003774767878481013	1.538628	45	51	0.004179049	
GO Cellular Component	DNA-directed RNA polymerase III complex	70	4.954223e-17	1.2229853348571428e-15	4.690988	46	0.002549889	112	0.00039541160571428567	1.743778	19	19	0.001764487	
GO Cellular Component	spliceosomal snRNP complex	99	1.473049e-12	2.571140072727273e-11	2.135324	108	0.005986696	124	0.0012899911587096774	1.406272	50	62	0.004643388	
GO Cellular Component	proteasome core complex, beta-subunit complex	103	6.265786e-12	1.0511920590291262e-10	5.166142	28	0.001552106	168	0.02264045142857143	1.743778	11	11	0.001021545	
GO Cellular Component	ESCRT complex	128	1.252981e-9	1.69152435e-8	2.454159	59	0.00327051	191	0.04707072904712041	1.432389	23	28	0.002135958	
GO Cellular Component	methylosome	164	7.864444e-8	8.286438556097561e-7	3.521179	26	0.001441242	160	0.0136268028	1.743778	12	12	0.001114413	
GO Cellular Component	spliceosomal tri-snRNP complex	166	8.95198e-8	9.318687614457832e-7	2.274413	53	0.002937916	180	0.0341521632	1.443127	24	29	0.002228826	
GO Cellular Component	prespliceosome	183	2.882012e-7	0.0000027213752655737707	2.447482	42	0.00232816	158	0.012261811443037975	1.577704	19	21	0.001764487	
GO Cellular Component	signal recognition particle	194	6.090358e-7	0.00000542481372371134	3.44682	23	0.001274945	181	0.036658870806629835	1.743778	10	10	0.0009286776	
GO Cellular Component	mitochondrial small ribosomal subunit	204	9.63212e-7	0.000008158972235294119	2.233969	46	0.002549889	191	0.04707072904712041	1.432389	23	28	0.002135958	
GO Cellular Component	U1 snRNP	231	0.000006804841	0.00005090374566233766	2.150107	42	0.00232816	144	0.0046609392	1.652	18	19	0.00167162	
GO Molecular Function	threonine-type endopeptidase activity	16	9.705216e-22	2.560963872e-19	4.294978	66	0.003658537	151	0.04469280582781457	1.525806	21	24	0.001950223	
GO Molecular Function	unfolded protein binding	17	1.399069e-21	3.474629010588235e-19	2.170776	190	0.01053215	103	0.0030741005052427185	1.316059	80	106	0.007429421	
GO Molecular Function	rRNA binding	24	9.403591e-19	1.654248383416667e-16	2.796934	100	0.005543237	102	0.002416438106470588	1.424085	49	60	0.00455052	
GO Molecular Function	RNA polymerase III activity	36	1.180635e-14	1.3846224916666667e-12	4.462263	41	0.002272727	110	0.005226383094545454	1.743778	16	16	0.001485884	
GO Molecular Function	snRNA binding	57	1.541479e-11	1.1417761996491228e-9	2.591056	66	0.003658537	122	0.013855506972131148	1.468445	32	38	0.002971768	
GO Molecular Function	5'-3' RNA polymerase activity	59	1.699184e-11	1.2159245505084746e-9	2.324461	81	0.004490022	107	0.003914515685794392	1.472524	38	45	0.003528975	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	66	5.020494e-11	3.211594798181818e-9	2.312153	78	0.004323725	117	0.0078657122991453	1.459907	36	43	0.003343239	
GO Molecular Function	aminoacyl-tRNA editing activity	85	8.642815e-10	4.2929370505882353e-8	3.310405	37	0.002050998	135	0.02261813280148148	1.743778	13	13	0.001207281	
GO Molecular Function	NF-kappaB binding	91	1.894759e-9	8.790848898901099e-8	2.218039	71	0.003935698	148	0.038475685067567565	1.494667	24	28	0.002228826	
GO Molecular Function	fatty-acyl-CoA binding	235	0.000006114146	0.00010984648685957446	2.207659	40	0.002217295	144	0.03126165240277778	1.641203	16	17	0.001485884	
Human Phenotype	Increased serum lactate	9	2.148635e-23	1.5930934838888888e-20	2.162949	209	0.01158537	64	0.0000143881244953125	1.429898	82	100	0.007615156	
Human Phenotype	Exercise intolerance	20	3.024334e-16	1.0090690391e-13	2.230309	131	0.007261641	127	0.0028610025118897637	1.395022	56	70	0.005200594	
Human Phenotype	Abnormal CSF metabolite level	23	1.945886e-15	5.645607512173914e-13	2.262242	120	0.006651885	157	0.00844532329808917	1.383951	50	63	0.004643388	
Human Phenotype	Increased CSF lactate	45	7.765557e-13	1.1515458191333335e-10	2.185775	105	0.005820399	180	0.013636961336111112	1.382996	46	58	0.004271917	
Human Phenotype	Aplasia/hypoplasia of the femur	86	8.53587e-10	6.623239594186047e-8	2.050304	89	0.004933481	205	0.023936913607317072	1.479569	28	33	0.002600297	
Human Phenotype	CNS hypomyelination	189	5.648215e-7	0.000019942083965608466	2.088418	56	0.003104213	104	0.0009522294003846154	1.627526	28	30	0.002600297	
Human Phenotype	Increased intramyocellular lipid droplets	261	0.000007545228	0.00019290922009195403	2.397658	33	0.001829268	224	0.03176356937053571	1.641203	16	17	0.001485884	
Human Phenotype	Increased hepatocellular lipid droplets	369	0.0000718399	0.0012991535303523035	2.382819	26	0.001441242	230	0.036606946491304346	1.743778	12	12	0.001114413	
Human Phenotype	Abnormal activity of mitochondrial respiratory chain	404	0.0001070612	0.0017683648207920792	2.011934	36	0.001995565	246	0.0477116787398374	1.634792	15	16	0.001393016	
Mouse Phenotype Single KO	expanded mesangial matrix	36	1.321561e-28	3.361537243611111e-26	2.53688	187	0.01036585	222	0.01339557731081081	1.494667	30	35	0.002786033	
Mouse Phenotype Single KO	abnormal mesangial matrix morphology	38	2.239329e-28	5.396193592894736e-26	2.48983	192	0.01064302	192	0.006727881594270833	1.508132	32	37	0.002971768	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	152	5.727056e-14	3.4501744600000007e-12	2.751773	74	0.004101996	175	0.004083419207771428	1.743778	17	17	0.001578752	
Mouse Phenotype Single KO	spleen atrophy	194	4.82018e-12	2.2751746525773194e-10	2.222893	94	0.005210643	282	0.0364059265141844	1.577704	19	21	0.001764487	
Mouse Phenotype Single KO	increased neural tube apoptosis	257	8.802761e-10	3.136454571089494e-8	2.08806	85	0.004711752	255	0.023835545315686272	1.542573	23	26	0.002135958	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	479	0.000001502956	0.00002873187493110647	2.050379	54	0.002993348	313	0.04676330696485623	1.525806	21	24	0.001950223	
Mouse Phenotype	abnormal mesangial matrix morphology	44	1.015729e-27	2.2071329475e-25	2.252928	229	0.01269401	378	0.03362277411904762	1.367669	40	51	0.00371471	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	58	3.161263e-25	5.211178541896552e-23	2.63215	153	0.008481153	381	0.03384606547244094	1.494667	24	28	0.002228826	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	158	3.289858e-14	1.990780527721519e-12	2.522218	88	0.004878049	260	0.006213054048461538	1.604276	23	25	0.002135958	
Mouse Phenotype	dry skin	186	4.078968e-13	2.0967211316129032e-11	2.123402	115	0.006374723	436	0.049408287598623854	1.395022	32	40	0.002971768	
Mouse Phenotype	increased neural tube apoptosis	200	1.435667e-12	6.8632060935e-11	2.080279	115	0.006374723	205	0.0024528488985365855	1.50046	37	43	0.003436107	
Mouse Phenotype	fusion of vertebral bodies	282	2.267731e-10	7.688573081914892e-9	3.287058	40	0.002217295	433	0.0486033324595843	1.743778	11	11	0.001021545	
Mouse Phenotype	decreased embryonic cilium length	464	2.751039e-7	0.000005668681870474137	2.759791	34	0.001884701	373	0.03234183834048258	1.743778	12	12	0.001114413