# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	10	6.736476e-51	8.864528768400001e-48	2.697157	306	0.01862447	509	0.003724276208644401	1.318795	80	113	0.007936508	
GO Biological Process	endoplasmic reticulum unfolded protein response	15	1.5759e-45	1.3824845400000001e-42	2.634946	284	0.01728545	317	0.00005359141811987381	1.405268	86	114	0.008531746	
GO Biological Process	rRNA metabolic process	17	5.641656e-45	4.366973606117647e-42	2.076805	456	0.02775411	92	3.684050853043479e-14	1.452838	202	259	0.02003968	
GO Biological Process	regulation of DNA-templated transcription in response to stress	18	2.188923e-44	1.6002243198333333e-41	2.454527	315	0.01917225	451	0.0015721629176718404	1.33057	85	119	0.00843254	
GO Biological Process	rRNA processing	20	5.07689e-44	3.3403397755e-41	2.082814	443	0.02696287	100	1.5805445967000002e-13	1.448843	196	252	0.01944444	
GO Biological Process	IRE1-mediated unfolded protein response	22	1.760133e-43	1.0527995521363637e-40	3.595365	170	0.01034693	793	0.04470771079697352	1.348922	42	58	0.004166667	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	23	2.335405e-43	1.3361562780434782e-40	2.218017	378	0.0230067	274	0.000012846459342335766	1.370058	114	155	0.01130952	
GO Biological Process	nuclear-transcribed mRNA catabolic process	24	7.338096e-43	4.023416886e-40	2.175056	390	0.02373707	130	1.3779740396923077e-11	1.467659	156	198	0.01547619	
GO Biological Process	mRNA catabolic process	26	1.940632e-42	9.821837110769233e-40	2.103004	417	0.0253804	104	4.987781033557693e-13	1.477994	169	213	0.01676587	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	29	3.635172e-41	1.6494906326896552e-38	2.541315	273	0.01661595	515	0.004025136243495146	1.347556	68	94	0.006746032	
GO Biological Process	cellular response to topologically incorrect protein	30	6.329683e-41	2.7764099532333334e-38	2.351607	315	0.01917225	294	0.000024291545330952384	1.380346	103	139	0.01021825	
GO Biological Process	cellular response to unfolded protein	40	2.04645e-38	6.732308887500001e-36	2.379753	288	0.01752891	327	0.00008521221114373089	1.385552	90	121	0.008928571	
GO Biological Process	response to topologically incorrect protein	50	1.57052e-35	4.133294536e-33	2.053959	367	0.02233719	312	0.00004912621633653846	1.324656	128	180	0.01269841	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	51	2.693797e-35	6.950524455490196e-33	2.562606	229	0.01393792	183	1.8647956863387977e-8	1.515496	96	118	0.00952381	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	56	2.453117e-33	5.764386893392857e-31	2.629072	206	0.01253804	353	0.00022346740543909347	1.456803	61	78	0.006051587	
GO Biological Process	response to unfolded protein	58	5.30007e-32	1.2024762263793104e-29	2.036408	336	0.0204504	341	0.0001457045517829912	1.327243	114	160	0.01130952	
GO Biological Process	protein targeting to ER	69	3.041718e-29	5.800864806086957e-27	2.504079	196	0.0119294	222	3.7602589362162164e-7	1.51237	82	101	0.008134921	
GO Biological Process	cotranslational protein targeting to membrane	83	7.777895e-26	1.2331243410240965e-23	2.436336	181	0.01101643	220	3.5595932390909087e-7	1.520651	80	98	0.007936508	
GO Biological Process	protein localization to endoplasmic reticulum	84	1.003996e-25	1.5728075433333335e-23	2.159732	232	0.01412051	177	5.770559768079095e-9	1.517279	101	124	0.01001984	
GO Biological Process	antigen processing and presentation of peptide antigen via MHC class I	89	1.465265e-24	2.166451925280899e-22	2.432336	172	0.01046865	708	0.028008987258474578	1.297679	62	89	0.006150794	
GO Cellular Component	ribosomal subunit	30	8.044981e-34	4.633909056e-32	2.159065	310	0.01886792	39	9.228738461538462e-11	1.460031	145	185	0.01438492	
GO Cellular Component	large ribosomal subunit	39	5.016131e-26	2.222531889230769e-24	2.320962	201	0.01223372	42	5.850234514285715e-10	1.555031	96	115	0.00952381	
GO Cellular Component	mitochondrial ribosome	41	2.082598e-25	8.77738864390244e-24	2.748951	143	0.008703591	61	7.459444563934427e-7	1.534069	70	85	0.006944444	
GO Cellular Component	endopeptidase complex	46	7.010839e-22	2.633636911304348e-20	2.473871	147	0.008947048	99	0.0010455070254545454	1.430845	53	69	0.005257937	
GO Cellular Component	proteasome complex	48	4.138397e-21	1.48982292e-19	2.441592	145	0.00882532	103	0.0014528451914563108	1.424492	52	68	0.00515873	
GO Cellular Component	nuclear ubiquitin ligase complex	49	1.522281e-20	5.368370546938776e-19	3.079191	95	0.005782106	107	0.0021355576822429906	1.536808	33	40	0.00327381	
GO Cellular Component	mitochondrial large ribosomal subunit	51	1.664933e-19	5.641184752941176e-18	3.007844	93	0.005660377	71	0.00001965045336338028	1.60712	44	51	0.004365079	
GO Cellular Component	peptidase complex	53	3.848728e-18	1.254830563018868e-16	2.098232	170	0.01034693	91	0.0005734259762637362	1.397098	66	88	0.006547619	
GO Cellular Component	ESCRT complex	164	4.167406e-7	0.000004391022907317073	2.237926	49	0.002982349	131	0.004903755334351146	1.596684	24	28	0.002380952	
GO Cellular Component	anaphase-promoting complex	272	0.000225556	0.001432944	2.077286	30	0.001825928	164	0.022903807609756095	1.596684	18	21	0.001785714	
GO Molecular Function	structural constituent of ribosome	9	1.017367e-26	4.772581637777777e-24	2.05684	271	0.01649422	22	8.346425741818181e-10	1.483339	129	162	0.01279762	
GO Molecular Function	unfolded protein binding	14	1.53336e-21	4.624175657142856e-19	2.232957	178	0.01083384	107	0.009342445545794392	1.318017	75	106	0.007440476	
GO Molecular Function	ribonuclease activity	18	4.700172e-19	1.1024514546666667e-16	2.049078	190	0.01156421	75	0.0002612450880533333	1.41121	75	99	0.007440476	
GO Molecular Function	rRNA binding	23	2.000064e-15	3.6714218295652175e-13	2.671779	87	0.005295192	80	0.00103895556525	1.490238	48	60	0.004761905	
GO Molecular Function	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	43	1.617336e-12	1.5879982772093024e-10	2.205105	100	0.006086427	113	0.012081338934513275	1.452982	39	50	0.003869048	
GO Molecular Function	mRNA 5'-UTR binding	171	0.000001343359	0.00003316761226900585	2.163917	48	0.002921485	138	0.04092207153623188	1.60878	19	22	0.001884921	
GO Molecular Function	ubiquitin protein ligase activity involved in ERAD pathway	250	0.00002212508	0.00037364835104000004	2.563723	26	0.001582471	110	0.011760189090909092	1.862798	13	13	0.001289683	
GO Molecular Function	peptide disulfide oxidoreductase activity	268	0.00004081165	0.0006429357697761193	2.468966	26	0.001582471	110	0.011760189090909092	1.862798	13	13	0.001289683	
GO Molecular Function	5S rRNA binding	338	0.0002194477	0.0027411484893491126	2.60069	19	0.001156421	133	0.03378672959398496	1.862798	11	11	0.00109127	
Mouse Phenotype Single KO	absent hypoglossal nerve	49	4.456971e-19	8.329078254489797e-17	4.11839	60	0.003651856	240	0.0469725484375	1.738611	14	15	0.001388889	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	92	2.961005e-15	2.9471655201086956e-13	2.899929	75	0.00456482	164	0.01211853013902439	1.693452	20	22	0.001984127	
Mouse Phenotype Single KO	thin hypoglossal nerve	131	8.140231e-13	5.690083608167939e-11	3.085096	56	0.003408399	240	0.0469725484375	1.738611	14	15	0.001388889	
Mouse Phenotype Single KO	absent proamniotic cavity	173	4.04214e-11	2.1395304034682083e-9	4.196238	32	0.001947657	234	0.041650184042735044	1.862798	11	11	0.00109127	
Mouse Phenotype Single KO	retroesophageal right subclavian artery	187	1.048968e-10	5.136577527272726e-9	2.122147	91	0.005538649	232	0.04183201782758621	1.666714	17	19	0.001686508	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	365	0.000001056417	0.000026503042380821915	2.126226	51	0.003104078	191	0.023860217513089005	1.629948	21	24	0.002083333	
Mouse Phenotype Single KO	decreased embryonic cilium length	573	0.00009505975	0.0015191311182373474	2.340442	26	0.001582471	234	0.041650184042735044	1.862798	11	11	0.00109127	
Mouse Phenotype	absent hypoglossal nerve	53	4.456971e-19	8.040207496415094e-17	4.11839	60	0.003651856	326	0.03610670590490798	1.738611	14	15	0.001388889	
Mouse Phenotype	absent segment of posterior cerebral artery	95	2.961005e-15	2.9800177689473687e-13	2.899929	75	0.00456482	230	0.009022275062608696	1.693452	20	22	0.001984127	
Mouse Phenotype	abnormal vitelline vein morphology	104	7.7613e-15	7.135172048076922e-13	2.241729	117	0.00712112	351	0.041652836991452995	1.56475	21	25	0.002083333	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	142	4.974791e-13	3.349575827535211e-11	2.517612	80	0.004869142	351	0.041652836991452995	1.56475	21	25	0.002083333	
Mouse Phenotype	thin hypoglossal nerve	149	8.140231e-13	5.223405945704698e-11	3.085096	56	0.003408399	326	0.03610670590490798	1.738611	14	15	0.001388889	
Mouse Phenotype	increased neural tube apoptosis	179	1.109519e-11	5.926319083240224e-10	2.085509	105	0.006390749	272	0.017472460354411766	1.47291	34	43	0.003373016	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	185	1.549475e-11	8.007854310810812e-10	2.489825	71	0.004321363	210	0.006421645650000001	1.614425	26	30	0.002579365	
Mouse Phenotype	absent proamniotic cavity	199	4.04214e-11	1.942055303517588e-9	4.196238	32	0.001947657	315	0.03230519243809524	1.862798	11	11	0.00109127	
Mouse Phenotype	spleen atrophy	223	1.385754e-10	5.941342598206278e-9	2.140627	88	0.005356056	219	0.007921886608219178	1.647859	23	26	0.002281746	
Mouse Phenotype	decreased embryonic cilium length	541	0.0000176479	0.00031188830295748616	2.495481	28	0.0017042	282	0.01936191329148936	1.862798	12	12	0.001190476	
Mouse Phenotype	absent embryonic cilia	722	0.0002993014	0.003963463553185596	2.041454	30	0.001825928	368	0.04626684814402173	1.65582	16	18	0.001587302