# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	20	1.472372e-23	9.687471574e-21	2.646457	140	0.01827438	258	0.0007354748713953488	1.618797	57	113	0.009741924	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	21	2.280719e-23	1.4291419676666667e-20	2.873613	121	0.01579428	602	0.04962713563122924	1.419998	50	113	0.008545548	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	30	5.816594e-21	2.5513520148666666e-18	2.901304	106	0.01383631	277	0.0012273028757761734	1.728028	42	78	0.00717826	
GO Biological Process	translational elongation	32	9.986733e-21	4.1067318608437496e-18	2.753305	114	0.01488056	197	0.0000446063982390863	1.719212	60	112	0.01025466	
GO Biological Process	regulation of DNA-templated transcription in response to stress	33	1.519138e-20	6.0576778612121215e-18	2.406423	144	0.0187965	242	0.0004807671100578512	1.618082	60	119	0.01025466	
GO Biological Process	endoplasmic reticulum unfolded protein response	38	1.025474e-18	3.551108517368421e-16	2.46733	124	0.01618588	470	0.022808155925744682	1.463843	52	114	0.00888737	
GO Biological Process	mitochondrial translational termination	40	3.754153e-18	1.2350224831750001e-15	3.000643	86	0.01122569	224	0.00016706296303124998	1.77059	48	87	0.008203726	
GO Biological Process	mitochondrial translational elongation	43	1.359373e-17	4.159997513255814e-15	2.979451	84	0.01096463	227	0.0001920713726123348	1.774496	47	85	0.008032815	
GO Biological Process	mitochondrial translation	49	3.116491e-17	8.369368381428572e-15	2.641792	100	0.01305313	193	0.000041381359570984453	1.739564	58	107	0.009912835	
GO Biological Process	translational termination	50	3.244574e-17	8.5390698532e-15	2.736979	94	0.01226994	207	0.00009777728201449275	1.756612	52	95	0.00888737	
GO Biological Process	cellular response to unfolded protein	60	1.590193e-16	3.4875582811666665e-14	2.268305	128	0.016708	411	0.010713776050121656	1.485247	56	121	0.009571014	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	66	2.870151e-16	5.72247227409091e-14	2.495927	104	0.01357525	222	0.000155647022990991	1.658991	61	118	0.01042557	
GO Biological Process	response to unfolded protein	72	1.148061e-15	2.0982409304166667e-13	2.027693	156	0.02036288	217	0.00014247522182488478	1.564483	78	160	0.01333105	
GO Biological Process	protein complex disassembly	73	1.395369e-15	2.515295982328767e-13	2.044154	152	0.01984075	170	0.000011460676238235295	1.634873	81	159	0.01384379	
GO Biological Process	cellular response to topologically incorrect protein	76	2.021387e-15	3.4999252017105267e-13	2.145414	134	0.01749119	503	0.027101784572564614	1.408352	61	139	0.01042557	
GO Biological Process	cellular protein complex disassembly	77	3.348489e-15	5.72243724038961e-13	2.213315	123	0.01605535	226	0.00019087397338053098	1.630067	64	126	0.0109383	
GO Biological Process	multi-organism metabolic process	78	4.060374e-15	6.850059162307692e-13	2.153145	130	0.01696906	186	0.00002760410830698925	1.637344	75	147	0.01281832	
GO Biological Process	mitochondrial membrane organization	83	1.333987e-14	2.114931919638554e-12	2.034731	143	0.01866597	168	0.000007749097768035714	1.734001	67	124	0.01145103	
GO Biological Process	cotranslational protein targeting to membrane	91	5.172708e-14	7.47996313978022e-12	2.511482	87	0.01135622	254	0.0006856481407874016	1.670091	51	98	0.008716459	
GO Biological Process	viral gene expression	99	2.842928e-13	3.778796924444444e-11	2.238741	103	0.01344472	245	0.0005632675038367347	1.591963	63	127	0.01076739	
GO Cellular Component	mitochondrial ribosome	37	3.321787e-16	1.551364307027027e-14	3.050808	74	0.009659313	60	0.000686697984	1.698986	45	85	0.007690993	
GO Cellular Component	ribosomal subunit	38	3.339536e-16	1.518610054736842e-14	2.135955	143	0.01866597	58	0.0004816496110344828	1.474495	85	185	0.01452743	
GO Cellular Component	peptidase complex	39	5.16221e-16	2.2872561230769227e-14	2.567606	97	0.01266153	66	0.001904321716363636	1.641066	45	88	0.007690993	
GO Cellular Component	endopeptidase complex	41	1.011076e-14	4.261315434146341e-13	2.77909	77	0.01005091	74	0.005181099762162162	1.674363	36	69	0.006152794	
GO Cellular Component	proteasome complex	43	7.704634e-14	3.0961878027906977e-12	2.708435	75	0.009789845	85	0.007698479887058823	1.651792	35	68	0.005981883	
GO Cellular Component	catalytic step 2 spliceosome	47	5.437096e-13	1.9990004017021276e-11	2.276463	97	0.01266153	113	0.026853594053097344	1.470881	44	96	0.007520082	
GO Cellular Component	mitochondrial large ribosomal subunit	48	8.263489e-12	2.97485604e-10	3.260036	47	0.006134969	83	0.007588478689156627	1.761911	28	51	0.004785507	
GO Cellular Component	large ribosomal subunit	53	5.406899e-11	1.7628531079245281e-9	2.179248	88	0.01148675	78	0.005989303384615384	1.506926	54	115	0.009229192	
GO Cellular Component	proton-transporting ATP synthase complex	60	5.787274e-10	1.6667349120000003e-8	4.083156	29	0.003785407	84	0.007510389942857142	2.139463	16	24	0.002734575	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	72	4.932717e-9	1.1838520800000001e-7	3.927392	27	0.003524344	93	0.014754550296774192	2.092953	15	23	0.002563664	
GO Cellular Component	proton-transporting ATP synthase complex, catalytic core F(1)	83	3.856294e-8	8.028525339759036e-7	17.03541	8	0.00104425	98	0.016112919379591834	3.209195	6	6	0.001025466	
GO Cellular Component	preribosome	86	7.459004e-8	0.000001498739408372093	2.09999	64	0.008354001	87	0.00914252623448276	1.604598	38	76	0.006494616	
GO Cellular Component	mitochondrial nucleoid	87	1.197835e-7	0.0000023791481379310343	2.529979	42	0.005482313	107	0.020288060411214955	1.757416	23	42	0.003930952	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)	121	0.000004125918	0.00005892220085950413	14.94159	6	0.0007831876	124	0.04089125264516129	3.209195	5	5	0.0008545548	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	143	0.00003650907	0.00044117253818181816	3.233016	17	0.002219031	118	0.033297666711864404	2.406896	9	12	0.001538199	
GO Cellular Component	ESCRT III complex	160	0.0001001009	0.00108108972	3.238123	15	0.001957969	118	0.033297666711864404	2.406896	9	12	0.001538199	
GO Molecular Function	NF-kappaB binding	8	4.111353e-16	2.1697665457500002e-13	3.898862	53	0.006918157	55	0.005407797061090909	2.177668	19	28	0.003247308	
GO Molecular Function	structural constituent of ribosome	9	1.382086e-14	6.483518991111111e-12	2.116053	130	0.01696906	34	0.00024822367347058827	1.564978	79	162	0.01350197	
GO Molecular Function	protein transporter activity	13	8.122187e-13	2.6378364241538463e-10	2.161288	107	0.01396685	22	0.00005763352407272728	1.805172	54	96	0.009229192	
GO Molecular Function	ribonucleoprotein complex binding	15	5.881613e-12	1.6554780057333331e-9	2.113881	104	0.01357525	60	0.009224127086666667	1.534832	55	115	0.009400103	
GO Molecular Function	rRNA binding	21	1.302422e-9	2.618488420952381e-7	2.897918	44	0.005743376	88	0.03536053579090909	1.658084	31	60	0.00529824	
GO Molecular Function	ribonuclease activity	22	1.369497e-9	2.628189242727273e-7	2.035353	88	0.01148675	76	0.02675871935	1.523557	47	99	0.008032815	
GO Molecular Function	peptide disulfide oxidoreductase activity	26	2.753303e-9	4.470940486923077e-7	4.684052	23	0.003002219	92	0.041705044495652176	2.468612	10	13	0.00170911	
GO Molecular Function	disordered domain specific binding	81	0.00001106545	0.0005767695049382715	2.063053	44	0.005743376	77	0.028028443355844153	1.966926	19	31	0.003247308	
Human Phenotype	Progressive external ophthalmoplegia	1	4.065283e-16	2.7127633459e-12	5.677797	36	0.004699125	135	0.04736651597629629	2.35341	11	15	0.001880021	
Human Phenotype	Increased serum lactate	2	1.787339e-15	5.963456573500001e-12	2.461345	101	0.01318366	66	0.002752811678939394	1.636689	51	100	0.008716459	
Human Phenotype	Generalized amyloid deposition	3	1.550817e-14	3.449533947e-11	10.80303	20	0.002610625	132	0.04619593539545454	3.209195	6	6	0.001025466	
Human Phenotype	Dysphonia	5	2.801488e-11	3.7388658848e-8	3.345477	43	0.005612844	49	0.0006060025029183673	2.511544	18	23	0.003076397	
Human Phenotype	Abnormal CSF metabolite level	31	3.041958e-8	0.000006548059914193549	2.352799	53	0.006918157	129	0.04615207158914729	1.630067	32	63	0.005469151	
Human Phenotype	Increased CSF lactate	35	5.36008e-8	0.000010219375382857143	2.401946	49	0.006396032	127	0.045772061611023616	1.659928	30	58	0.005127329	
Human Phenotype	Death in infancy	40	1.003072e-7	0.00001673374864	2.206607	56	0.007309751	106	0.02528641438867925	1.719212	30	56	0.005127329	
Human Phenotype	Hypergonadotropic hypogonadism	77	0.000004606704	0.0003992277375584416	2.119291	45	0.005873907	71	0.00300872411971831	2.258322	19	27	0.003247308	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	15	2.098019e-11	1.2807706655333334e-8	2.468807	71	0.00926772	69	0.0016018326828985507	1.87203	35	60	0.005981883	
Mouse Phenotype Single KO	early cellular replicative senescence	23	3.245574e-9	0.0000012921617877391306	2.365929	60	0.007831876	60	0.0009072081034333334	1.974889	32	52	0.005469151	
Mouse Phenotype Single KO	abnormal DNA replication	37	4.266042e-8	0.000010557877457837838	2.993758	34	0.004438063	59	0.0006906381675762711	2.511544	18	23	0.003076397	
Mouse Phenotype Single KO	intestine polyps	125	0.0000351835	0.002577402476	3.766352	14	0.001827438	155	0.04650741640709678	2.625705	9	11	0.001538199	
Mouse Phenotype Single KO	increased circulating glucagon level	185	0.0002041209	0.010103432871891893	2.008935	33	0.004307532	75	0.00239382294	2.642866	14	17	0.002392753	
Mouse Phenotype	Meibomian gland atrophy	2	8.136141e-18	3.88948220505e-14	9.073203	28	0.003654875	212	0.01283279223962264	3.209195	7	7	0.001196377	
Mouse Phenotype	early cellular replicative senescence	3	1.05116e-16	3.35004692e-13	2.591045	100	0.01305313	63	0.00003963902578095238	1.934309	44	73	0.007520082	
Mouse Phenotype	abnormal cellular replicative senescence	5	3.331628e-16	6.3707390616e-13	2.452987	107	0.01396685	62	0.000035854891151612904	1.87203	49	84	0.008374637	
Mouse Phenotype	dry eyes	70	3.120186e-7	0.00004261728335142858	2.572075	38	0.004960188	148	0.0033741815541891893	2.607471	13	16	0.002221842	
Mouse Phenotype	abnormal DNA replication	108	0.000006598868	0.0005841831198888889	2.341784	35	0.004568594	137	0.002234098631386861	2.258322	19	27	0.003247308