# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process mRNA catabolic process 60 1.755538e-35 3.8501874236666666e-33 2.029627 377 0.02449483 305 0.000029944896523278687 1.336838 140 213 0.01516464 GO Biological Process regulation of intrinsic apoptotic signaling pathway 69 6.735011e-34 1.2844349238985506e-31 2.092138 334 0.02170099 615 0.0059903041702439016 1.285952 98 155 0.01061525 GO Biological Process nuclear-transcribed mRNA catabolic process 73 1.621155e-33 2.922298444520548e-31 2.053977 345 0.0224157 287 0.000019947452998954704 1.355936 132 198 0.01429809 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 94 4.015598e-30 5.621410008723404e-28 2.472791 207 0.01344942 463 0.0008873849808207344 1.378918 80 118 0.008665511 GO Biological Process RNA phosphodiester bond hydrolysis 97 8.02627e-30 1.088842133298969e-27 2.240747 250 0.01624326 715 0.014246984279580419 1.284571 84 133 0.009098787 GO Biological Process cellular response to epidermal growth factor stimulus 115 5.721151e-27 6.546489218173912e-25 2.564718 172 0.01117536 686 0.01107219360437318 1.55219 29 38 0.003141248 GO Biological Process multi-organism metabolic process 123 7.165385e-26 7.665796846747968e-24 2.085783 253 0.01643818 201 2.7527737639800995e-7 1.480461 107 147 0.01159012 GO Biological Process response to epidermal growth factor 138 2.578272e-24 2.4585131339130437e-22 2.404222 174 0.01130531 756 0.017438842907407406 1.501215 31 42 0.003357886 GO Biological Process viral gene expression 146 6.978872e-24 6.29006689369863e-22 2.207067 204 0.0132545 268 0.000009878102864552238 1.457364 91 127 0.009857019 GO Biological Process ribonucleoprotein complex export from nucleus 165 1.693854e-22 1.3508742294545454e-20 2.131438 207 0.01344942 420 0.00046918257845238095 1.383055 85 125 0.009207106 GO Biological Process liver regeneration 172 4.041225e-22 3.0917720799418606e-20 2.764361 122 0.00792671 876 0.03298079526826484 1.5109 26 35 0.002816291 GO Biological Process cytoplasmic translation 192 4.822709e-21 3.3053139443229166e-19 3.279884 89 0.0057826 856 0.02926859829672897 1.466303 31 43 0.003357886 GO Biological Process regulation of plasma lipoprotein particle levels 193 5.993584e-21 4.086506313782383e-19 2.248849 170 0.01104542 804 0.023638081268656713 1.365223 49 73 0.005307626 GO Biological Process ribonucleoprotein complex localization 195 8.791515e-21 5.93269466076923e-19 2.056067 207 0.01344942 473 0.0010446802126638478 1.361274 85 127 0.009207106 GO Biological Process RNA phosphodiester bond hydrolysis, endonucleolytic 198 1.029219e-20 6.84014788939394e-19 2.468905 139 0.009031252 718 0.014360686111281338 1.394677 48 70 0.005199307 GO Biological Process ncRNA transcription 203 1.731062e-20 1.1221204363546798e-18 2.223942 170 0.01104542 440 0.0006820345588181818 1.436997 65 92 0.007040728 GO Biological Process regulation of mitochondrial membrane permeability 206 2.401693e-20 1.5341688440291264e-18 2.149895 182 0.01182509 956 0.042393989666317994 1.337361 48 73 0.005199307 GO Biological Process snRNA metabolic process 211 4.925497e-20 3.071782702511848e-18 2.347746 148 0.009616009 520 0.0021275597728846155 1.419003 60 86 0.006499133 GO Biological Process viral transcription 217 7.557843e-20 4.583117789723502e-18 2.124952 182 0.01182509 315 0.000037800434786031746 1.457931 81 113 0.00877383 GO Biological Process cotranslational protein targeting to membrane 221 1.356564e-19 8.077387183710407e-18 2.255948 157 0.01020077 377 0.00021033855205835543 1.452788 70 98 0.007582322 GO Cellular Component ribosomal subunit 53 3.576953e-25 1.1662216573584904e-23 2.007421 270 0.01754272 66 6.245447563636364e-7 1.407242 128 185 0.01386482 GO Cellular Component large ribosomal subunit 57 2.760951e-23 8.370040926315789e-22 2.280418 185 0.01202001 68 0.0000037611876705882356 1.485634 84 115 0.009098787 GO Cellular Component nuclear chromosome, telomeric region 63 2.24335e-21 6.153188571428571e-20 2.082099 207 0.01344942 83 0.0003337994255421687 1.371344 89 132 0.009640381 GO Cellular Component catalytic step 2 spliceosome 71 1.482328e-18 3.607694061971831e-17 2.07935 178 0.0115652 99 0.0013577765236363636 1.398309 66 96 0.007149047 GO Cellular Component mitochondrial ribosome 75 1.240258e-17 2.857554432e-16 2.442017 119 0.007731791 128 0.018242144999999998 1.339984 56 85 0.006065858 GO Cellular Component fibrinogen complex 83 1.943977e-16 4.047219585542169e-15 3.744711 57 0.003703463 133 0.021769928661654135 2.033904 9 9 0.00097487 GO Cellular Component high-density lipoprotein particle 90 1.584899e-15 3.04300608e-14 3.514083 58 0.003768436 136 0.028721736 1.581925 21 27 0.002274697 GO Cellular Component mitochondrial large ribosomal subunit 101 3.58793e-14 6.138557465346535e-13 2.693009 78 0.005067897 131 0.020571312366412214 1.435697 36 51 0.00389948 GO Cellular Component PcG protein complex 115 7.460976e-13 1.1210927415652175e-11 2.012271 128 0.008316549 148 0.04736763243243243 1.41489 32 46 0.003466205 GO Cellular Component Fanconi anaemia nuclear complex 127 7.795908e-12 1.0607345688188976e-10 2.939471 55 0.003573517 129 0.018919416558139536 1.87745 12 13 0.001299827 GO Cellular Component cytosolic large ribosomal subunit 128 1.617103e-11 2.18308905e-10 2.063128 106 0.006887142 98 0.0013694853159183674 1.500421 45 61 0.00487435 GO Cellular Component axon cytoplasm 136 5.278004e-11 6.706169788235294e-10 2.131497 93 0.006042492 137 0.029114668379562048 1.47458 29 40 0.003141248 GO Cellular Component nuclear euchromatin 145 8.695215e-10 1.03622976e-8 2.049053 89 0.0057826 130 0.02071970363076923 1.627123 20 25 0.002166378 GO Molecular Function protein transporter activity 14 2.4422e-23 7.364977428571428e-21 2.141545 213 0.01383926 55 0.000046724267567272736 1.504241 71 96 0.007690641 GO Molecular Function endoribonuclease activity 28 1.046225e-17 1.5775578392857142e-15 2.458622 118 0.007666818 135 0.04737965928888889 1.416469 39 56 0.004224437 GO Molecular Function O-methyltransferase activity 280 0.000007882335 0.00011885435132142858 2.15893 41 0.002663894 112 0.021555534089285712 1.743346 18 21 0.00194974 Human Phenotype Abnormality of mitochondrial metabolism 22 1.051559e-17 3.1895696395454547e-15 2.230182 144 0.009356117 122 0.025658904736885244 1.41489 48 69 0.005199307 Human Phenotype Hepatocellular carcinoma 157 1.965121e-8 8.352390084713375e-7 2.030898 76 0.004937951 160 0.041531067067500003 1.680181 19 23 0.002058059 Human Phenotype CNS hypomyelination 299 0.000003021375 0.00006743021864548495 2.098168 48 0.003118706 131 0.026407908486259544 1.627123 24 30 0.002599653 Human Phenotype Weight loss 398 0.00002557311 0.00042876724379396986 2.028272 42 0.002728868 94 0.014113970013829786 2.033904 12 12 0.001299827 Mouse Phenotype Single KO extramedullary hematopoiesis 21 9.833402e-33 4.287831529238095e-30 2.179684 293 0.0190371 477 0.03410519850733753 1.284571 72 114 0.00779896 Mouse Phenotype Single KO abnormal branching of the mammary ductal tree 93 1.614488e-18 1.5896630769892473e-16 2.107533 172 0.01117536 480 0.03498862992083333 1.498666 28 38 0.003032929 Mouse Phenotype Single KO abnormal cellular replicative senescence 192 5.354617e-14 2.553761868177083e-12 2.128886 123 0.007991683 401 0.01953163666109726 1.423733 42 60 0.004549393 Mouse Phenotype Single KO early cellular replicative senescence 254 1.010986e-11 3.644723937795276e-10 2.080535 106 0.006887142 421 0.023077575802850355 1.447201 37 52 0.004007799 Mouse Phenotype Single KO abnormal infrahyoid muscle morphology 285 7.618585e-11 2.4478379945614036e-9 3.550442 38 0.002468975 396 0.019040453020959597 2.033904 10 10 0.001083189 Mouse Phenotype Single KO abnormal pharyngeal muscle morphology 296 1.188188e-10 3.6757559175675672e-9 3.425957 39 0.002533948 347 0.010677589780979827 2.033904 11 11 0.001191508 Mouse Phenotype Single KO abnormal infrahyoid muscle connection 318 2.426718e-10 6.987879473584905e-9 3.54606 36 0.002339029 464 0.03306740711853448 2.033904 9 9 0.00097487 Mouse Phenotype Single KO absent segment of posterior cerebral artery 363 1.639542e-9 4.135891485950413e-8 2.43528 59 0.003833409 467 0.03319200732119914 1.664103 18 22 0.00194974 Mouse Phenotype Single KO distorted hair follicle pattern 532 3.457917e-7 0.000005951907137030075 2.731182 34 0.002209083 464 0.03306740711853448 2.033904 9 9 0.00097487 Mouse Phenotype Single KO gastrointestinal tract polyps 561 8.644712e-7 0.000014110450585383243 2.619012 34 0.002209083 446 0.028998268517937218 1.87745 12 13 0.001299827 Mouse Phenotype Single KO abnormal telomere length 774 0.00002452928 0.0002901997635142119 2.118346 38 0.002468975 387 0.0175967395250646 1.888625 13 14 0.001408146 Mouse Phenotype abnormal cellular replicative senescence 89 2.758116e-23 2.962960345617978e-21 2.225178 195 0.01266974 233 0.0001434277616781116 1.501215 62 84 0.006715771 Mouse Phenotype early cellular replicative senescence 114 1.324983e-20 1.1112423213157894e-18 2.218309 172 0.01117536 241 0.00016997886980912863 1.532393 55 73 0.005957539 Mouse Phenotype increased hepatocyte apoptosis 132 1.480626e-19 1.0724443322727272e-17 2.072641 190 0.01234488 508 0.008829099803740158 1.41489 48 69 0.005199307 Mouse Phenotype abnormal hair follicle outer root sheath morphology 137 4.524202e-19 3.157364622043796e-17 2.500406 124 0.008056656 642 0.02077358084112149 1.598067 22 28 0.002383016 Mouse Phenotype increased liver adenoma incidence 188 7.201133e-17 3.6622357772872344e-15 2.965331 81 0.005262816 642 0.02077358084112149 1.598067 22 28 0.002383016 Mouse Phenotype pancytopenia 215 1.02897e-15 4.575805660465117e-14 2.528983 98 0.006367358 579 0.014096546849740932 1.613096 23 29 0.002491334 Mouse Phenotype increased respiratory quotient 219 1.530355e-15 6.68115258219178e-14 2.124667 139 0.009031252 808 0.0424630870730198 1.380149 38 56 0.004116118 Mouse Phenotype abnormal infrahyoid muscle morphology 371 7.618585e-11 1.963377120889488e-9 3.550442 38 0.002468975 573 0.013739405619371727 2.033904 10 10 0.001083189 Mouse Phenotype abnormal infrahyoid muscle connection 400 2.426718e-10 5.800462699500001e-9 3.54606 36 0.002339029 670 0.02391076241641791 2.033904 9 9 0.00097487 Mouse Phenotype abnormal pharyngeal muscle morphology 425 5.746865e-10 1.2928417944705882e-8 3.179535 40 0.002598921 429 0.00443100199090909 2.033904 12 12 0.001299827 Mouse Phenotype decreased liver cholesterol level 433 1.025667e-9 2.2647580108545033e-8 2.051152 88 0.005717627 565 0.01286689766283186 1.588987 25 32 0.002707972 Mouse Phenotype absent segment of posterior cerebral artery 445 1.639542e-9 3.5226204633707864e-8 2.43528 59 0.003833409 678 0.023871010747787608 1.664103 18 22 0.00194974 Mouse Phenotype distorted hair follicle pattern 666 3.767236e-7 0.000005408189699099099 2.517826 39 0.002533948 492 0.007862989719512195 2.033904 11 11 0.001191508 Mouse Phenotype decreased splenocyte apoptosis 743 0.000001398447 0.000017995359040376853 2.324158 41 0.002663894 670 0.02391076241641791 2.033904 9 9 0.00097487 Mouse Phenotype embryonic lethality before implantation, incomplete penetrance 792 0.000003078987 0.00003716943776136364 2.155644 45 0.002923787 847 0.047430800295159385 1.591751 18 23 0.00194974