# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	response to epidermal growth factor	114	3.677836e-38	4.245319642456141e-36	2.540071	253	0.0119441	846	0.01872281496335697	1.354762	36	42	0.003030303	
GO Biological Process	regulation of mitochondrial membrane permeability	123	4.194144e-36	4.4870521053658535e-34	2.360361	275	0.01298272	483	0.0010260429200414079	1.34239	62	73	0.005218855	
GO Biological Process	mitochondrial membrane organization	127	3.169373e-35	3.283919630472441e-33	2.001885	389	0.01836465	806	0.016420897327543423	1.210909	95	124	0.007996633	
GO Biological Process	regulation of membrane permeability	153	3.05225e-31	2.6251344934640525e-29	2.158801	286	0.01350203	559	0.002460163325939177	1.307373	67	81	0.005639731	
GO Biological Process	negative regulation of stem cell differentiation	211	2.764739e-26	1.7242275118957345e-24	2.848262	140	0.006609385	1004	0.039466658913346615	1.492747	17	18	0.001430976	
GO Biological Process	regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway	316	1.532172e-19	6.380332705063291e-18	2.191973	167	0.007884052	837	0.018478160222222224	1.340036	39	46	0.003282828	
GO Biological Process	negative regulation of cyclin-dependent protein kinase activity	689	2.08089e-11	3.9742280856313497e-10	2.141988	96	0.00453215	780	0.014270230312564103	1.458974	24	26	0.002020202	
GO Biological Process	endocytic recycling	790	2.442599e-10	4.068627878607595e-9	2.058614	94	0.00443773	1005	0.03948955669751243	1.404938	24	27	0.002020202	
GO Biological Process	negative regulation of cyclin-dependent protein serine/threonine kinase activity	1019	8.050954e-9	1.0396712824926399e-7	2.024435	81	0.003824002	915	0.026144732642622952	1.448843	22	24	0.001851852	
GO Biological Process	protein-cofactor linkage	1383	7.430646e-7	0.000007070128034273319	2.637863	34	0.001605136	975	0.03504639844102564	1.580556	13	13	0.001094276	
GO Molecular Function	mitogen-activated protein kinase binding	97	2.502661e-10	1.0893025507216494e-8	2.085267	91	0.0042961	115	0.02109556443130435	1.463477	25	27	0.002104377	
Human Phenotype	Hypoplasia of the odontoid process	6	2.64553e-22	2.942270281666667e-19	3.558427	85	0.004012841	424	0.04739106368632076	1.492747	17	18	0.001430976	
Human Phenotype	Epistaxis	60	6.06089e-14	6.740719828333333e-12	2.077201	130	0.006137286	393	0.03812410549363868	1.343472	34	40	0.002861953	
Human Phenotype	Menorrhagia	233	2.803866e-8	8.030127818884121e-7	2.384416	52	0.002454915	224	0.0049475409410714285	1.580556	19	19	0.001599327	
Mouse Phenotype Single KO	extramedullary hematopoiesis	22	1.107542e-46	4.609891860909092e-44	2.216203	410	0.01935606	641	0.014283607163338534	1.220078	88	114	0.007407407	
Mouse Phenotype Single KO	pale liver	46	7.99471e-34	1.5914686841304348e-31	2.260183	281	0.01326598	443	0.0028484677832957108	1.303958	66	80	0.005555556	
Mouse Phenotype Single KO	decreased creatinine clearance	835	3.591542e-7	0.000003938652705868264	2.229351	50	0.002360495	549	0.006927672473952641	1.580556	17	17	0.001430976	
Mouse Phenotype	extramedullary hematopoiesis	28	7.57775e-62	2.5875309910714284e-59	2.038813	663	0.03130016	461	0.0002612600284164859	1.237349	137	175	0.01153199	
Mouse Phenotype	pale kidney	117	2.607041e-28	2.1304204274358974e-26	2.264034	232	0.0109527	1228	0.036707162679967424	1.299568	37	45	0.003114478	
Mouse Phenotype	lymph node hyperplasia	176	1.108922e-21	6.024092751136364e-20	2.166513	192	0.0090643	1294	0.04587220025656878	1.293182	36	44	0.003030303	
Mouse Phenotype	abnormal mesenchymal cell proliferation involved in lung development	341	1.749695e-15	4.905816391495601e-14	2.1288	138	0.006514966	1214	0.035598351590609555	1.487582	16	17	0.001346801	
Mouse Phenotype	pup cannibalization	476	2.274046e-12	4.5676793710084034e-11	2.163868	103	0.004862619	928	0.013664688349137932	1.501528	19	20	0.001599327	
Mouse Phenotype	abnormal pituitary intermediate lobe morphology	690	1.756938e-9	2.4345049591304346e-8	2.168619	75	0.003540742	1063	0.023355823066792097	1.580556	13	13	0.001094276	
Mouse Phenotype	increased urine magnesium level	932	1.974542e-7	0.0000020256004358369098	2.453595	43	0.002030025	1301	0.047706737024596456	1.580556	11	11	0.0009259259	
Mouse Phenotype	decreased creatinine clearance	981	3.591542e-7	0.0000035003805363914377	2.229351	50	0.002360495	764	0.005197762563612565	1.580556	17	17	0.001430976	
Mouse Phenotype	abnormal urine magnesium level	1109	0.000001804541	0.0000155574540135257	2.121389	49	0.002313285	887	0.01119495010822999	1.580556	15	15	0.001262626	
Mouse Phenotype	ketoaciduria	1380	0.00002143512	0.00014850810313043477	2.241477	34	0.001605136	1301	0.047706737024596456	1.580556	11	11	0.0009259259