# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process adherens junction assembly 130 1.877343e-24 1.900304349e-22 2.341192 185 0.008580705 883 0.03236607311438279 1.426119 28 34 0.002582311 GO Biological Process negative regulation of cyclin-dependent protein serine/threonine kinase activity 306 4.854792e-14 2.0877192133333334e-12 2.381819 97 0.004499072 850 0.027923196744705885 1.515252 21 24 0.001936733 GO Biological Process negative regulation of cyclin-dependent protein kinase activity 378 2.29295e-12 7.982256362433862e-11 2.192119 100 0.004638219 710 0.014072345802816901 1.531903 23 26 0.002121184 GO Biological Process negative regulation of cellular senescence 1061 0.000001497723 0.000018575435397737986 2.007002 57 0.002643785 794 0.022728128676322422 1.731716 12 12 0.001106705 GO Biological Process ubiquinone biosynthetic process 1657 0.0001009226 0.0008014728385033192 2.041356 35 0.001623377 861 0.029591839989547036 1.623484 15 16 0.001383381 GO Cellular Component mitochondrial small ribosomal subunit 147 0.000001001624 0.000011774192326530613 2.113053 52 0.002411874 102 0.02609881411764706 1.484328 24 28 0.00221341 Human Phenotype Hamartoma 85 1.155982e-14 9.075138689411763e-13 2.107033 133 0.006168831 167 0.0030072294059880233 1.603441 25 27 0.002305635 Human Phenotype 11 pairs of ribs 262 1.254698e-8 3.1956487610687024e-7 2.139687 69 0.003200371 266 0.01985733277744361 1.731716 13 13 0.00119893 Mouse Phenotype Single KO abnormal facial nerve morphology 83 4.517817e-21 4.98429521313253e-19 2.172504 185 0.008580705 602 0.02343332580564784 1.484328 24 28 0.00221341 Mouse Phenotype Single KO abnormal metanephros morphology 113 3.103798e-18 2.515175069557522e-16 2.166095 159 0.007374768 439 0.0055122303207289286 1.64513 19 20 0.001752283 Mouse Phenotype Single KO thoracic vertebral transformation 143 3.80547e-17 2.436831383916084e-15 2.156894 150 0.006957328 599 0.02323182876293823 1.370942 38 48 0.003504565 Mouse Phenotype Single KO cervical vertebral transformation 182 1.817654e-15 9.145196526373627e-14 2.183969 130 0.006029685 486 0.008946967436008231 1.458287 32 38 0.002951213 Mouse Phenotype Single KO lumbar vertebral transformation 394 4.103954e-10 9.538047405583756e-9 2.019984 96 0.00445269 606 0.02558768011221122 1.412716 31 38 0.002858987 Mouse Phenotype abnormal cell adhesion 41 5.48144e-35 1.2782450692682927e-32 2.041091 368 0.01706865 318 0.000020911434354716982 1.458287 64 76 0.005902426 Mouse Phenotype cervical vertebral fusion 88 1.062383e-25 1.1542549844318181e-23 2.052461 262 0.01215213 726 0.006610800684710745 1.40702 39 48 0.003596791 Mouse Phenotype thoracic vertebral transformation 101 4.798993e-24 4.542888324059406e-22 2.29697 189 0.008766234 752 0.00804992972074468 1.367144 45 57 0.004150143 Mouse Phenotype abnormal fourth pharyngeal arch morphology 121 4.25438e-22 3.361663403305785e-20 2.005596 236 0.0109462 1240 0.049571903641935484 1.396545 25 31 0.002305635 Mouse Phenotype abnormal aortic valve cusp morphology 133 9.539281e-21 6.857523732406015e-19 2.151382 186 0.008627087 1193 0.04131233567476949 1.367144 30 38 0.002766762 Mouse Phenotype abnormal metanephros morphology 138 1.756959e-20 1.2172670289130435e-18 2.143343 185 0.008580705 544 0.0013227151389705882 1.603441 25 27 0.002305635 Mouse Phenotype enlarged liver sinusoidal spaces 144 4.980909e-20 3.307116038125e-18 2.116145 186 0.008627087 1204 0.04251479705481728 1.351583 32 41 0.002951213 Mouse Phenotype sacral vertebral transformation 235 1.357835e-15 5.524366142553191e-14 3.439044 60 0.002782931 853 0.014103270815943729 1.566791 19 21 0.001752283 Mouse Phenotype abnormal rib development 253 4.031659e-15 1.5235846521343874e-13 2.131463 134 0.006215213 794 0.010306725487783375 1.469335 28 33 0.002582311 Mouse Phenotype absent sternum 276 1.150646e-14 3.9859878282608693e-13 2.10053 134 0.006215213 1112 0.03538906992356115 1.731716 10 10 0.000922254 Mouse Phenotype increased renal carcinoma incidence 420 5.178553e-12 1.1788606007857142e-10 3.99657 37 0.001716141 1112 0.03538906992356115 1.731716 10 10 0.000922254 Mouse Phenotype increased kidney tumor incidence 439 8.421079e-12 1.8340304400683368e-10 2.752694 61 0.002829314 930 0.019905477687096773 1.623484 15 16 0.001383381 Mouse Phenotype abnormal spinal cord central canal morphology 1050 0.000002173184 0.000019788392594285715 2.165031 46 0.002133581 1112 0.03538906992356115 1.731716 10 10 0.000922254 Mouse Phenotype decreased retinal apoptosis 1109 0.00000454874 0.00003921596315599639 2.015664 51 0.002365492 1112 0.03538906992356115 1.731716 10 10 0.000922254