# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	1	6.814384e-51	8.9670479056e-47	3.594707	199	0.02482225	173	0.000015356963743352602	1.699328	65	113	0.01022656	
GO Biological Process	regulation of DNA-templated transcription in response to stress	2	2.211709e-45	1.45519393655e-41	3.241746	203	0.02532119	163	0.00001220911395214724	1.688124	68	119	0.01069855	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	7	6.32646e-36	1.1892841020000002e-32	3.609442	138	0.01721342	164	0.000012427102839024388	1.855854	49	78	0.007709251	
GO Biological Process	nuclear-transcribed mRNA catabolic process	31	2.505688e-25	1.0636241416774193e-22	2.285923	200	0.02494699	131	0.00000438855462610687	1.55171	104	198	0.01636249	
GO Biological Process	response to topologically incorrect protein	33	3.918017e-25	1.5623389606969698e-22	2.282467	199	0.02482225	315	0.0030102570174603176	1.411459	86	180	0.01353052	
GO Biological Process	cellular response to topologically incorrect protein	35	5.778186e-25	2.1724328449714287e-22	2.509133	164	0.02045653	443	0.031273744749435665	1.381468	65	139	0.01022656	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	37	6.239201e-25	2.2189634042972974e-22	2.912566	127	0.01584134	109	0.0000014736824462385321	1.752501	70	118	0.01101322	
GO Biological Process	cellular response to unfolded protein	43	7.186074e-24	2.1991057620000002e-21	2.557067	151	0.01883498	492	0.044789491569105694	1.391656	57	121	0.008967904	
GO Biological Process	mRNA catabolic process	45	1.596122e-23	4.6674154217777775e-21	2.160111	209	0.0260696	177	0.000019356004298870056	1.497913	108	213	0.01699182	
GO Biological Process	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	46	1.793425e-23	5.1303651250000005e-21	3.277081	100	0.01247349	134	0.000004825257997761194	1.928447	47	72	0.007394588	
GO Biological Process	negative regulation of ubiquitin protein ligase activity	47	2.302497e-23	6.446501707021277e-21	3.19787	103	0.0128477	148	0.000007619896774324324	1.879956	49	77	0.007709251	
GO Biological Process	regulation of cellular amino acid metabolic process	50	2.682561e-23	7.0599640398e-21	3.870297	80	0.009978795	469	0.04085650650959488	1.575582	32	60	0.005034613	
GO Biological Process	RNA catabolic process	52	3.119254e-23	7.893512189615384e-21	2.053947	232	0.02893851	119	0.00000270205247302521	1.507754	123	241	0.01935179	
GO Biological Process	negative regulation of ubiquitin-protein transferase activity	55	7.535342e-23	1.8028648250545454e-20	3.008874	110	0.01372084	130	0.000003974689109	1.86397	53	84	0.008338578	
GO Biological Process	response to unfolded protein	56	1.113745e-22	2.617101866964286e-20	2.260594	182	0.02270176	362	0.008394424176795581	1.403253	76	160	0.01195721	
GO Biological Process	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	59	1.304512e-22	2.909503967457627e-20	3.230664	98	0.01222402	151	0.000008347098796953642	1.913999	46	71	0.007237256	
GO Biological Process	cellular response to epidermal growth factor stimulus	64	2.433924e-22	5.004375924375e-20	3.034394	106	0.0132219	305	0.0024559090400327866	1.943563	25	38	0.003933291	
GO Biological Process	regulation of mRNA stability	66	3.505932e-22	6.990084725454545e-20	2.166431	195	0.02432331	187	0.00002947252896042781	1.584712	81	151	0.01274386	
GO Biological Process	regulation of RNA stability	67	5.11793e-22	1.0051767294029852e-19	2.121118	203	0.02532119	166	0.00001316054578614458	1.587891	86	160	0.01353052	
GO Biological Process	anaphase-promoting complex-dependent catabolic process	69	1.147844e-21	2.189054955942029e-19	2.916429	109	0.01359611	162	0.000011918073808641977	1.846385	50	80	0.007866583	
GO Cellular Component	ribosomal subunit	29	4.027344e-25	2.399741528275862e-23	2.455038	172	0.02145441	38	2.2088278231578948e-7	1.612843	101	185	0.0158905	
GO Cellular Component	ribosome	31	2.13624e-23	1.1907815225806452e-21	2.136719	213	0.02656854	33	1.1722029381818182e-7	1.552215	124	236	0.01950913	
GO Cellular Component	mitochondrial ribosome	34	2.223808e-22	1.1302177129411766e-20	3.466885	88	0.01097667	44	0.0000027502121454545453	1.842041	53	85	0.008338578	
GO Cellular Component	large ribosomal subunit	42	6.307283e-18	2.5949964342857147e-16	2.579432	109	0.01359611	78	0.0038210112000000005	1.489953	58	115	0.009125236	
GO Cellular Component	endopeptidase complex	43	7.408676e-18	2.977253983255814e-16	2.966087	86	0.0107272	72	0.00217870824	1.669775	39	69	0.006135935	
GO Cellular Component	proteasome complex	44	2.155478e-17	8.465149963636364e-16	2.933254	85	0.01060247	75	0.0035514431999999997	1.650886	38	68	0.005978603	
GO Cellular Component	mitochondrial large ribosomal subunit	47	1.819535e-15	6.689694638297872e-14	3.645531	55	0.006860422	86	0.012368222288372093	1.679849	29	51	0.004562618	
GO Cellular Component	peptidase complex	48	3.062874e-15	1.1026346400000001e-13	2.478885	98	0.01222402	74	0.002848068583783784	1.57782	47	88	0.007394588	
GO Cellular Component	catalytic step 2 spliceosome	54	5.695428e-13	1.82253696e-11	2.242655	100	0.01247349	59	0.0001567114413559322	1.661747	54	96	0.008495909	
GO Cellular Component	nuclear ubiquitin ligase complex	69	1.015681e-9	2.543618504347826e-8	2.922748	44	0.005488337	87	0.01236802295172414	1.77253	24	40	0.00377596	
GO Cellular Component	small ribosomal subunit	75	6.506835e-9	1.4991747840000003e-7	2.249696	64	0.007983036	56	0.00006092995885714286	1.805355	44	72	0.006922593	
GO Cellular Component	proteasome accessory complex	87	7.417105e-8	0.0000014731905103448276	3.25484	29	0.003617313	80	0.00510387912	2.09257	17	24	0.002674638	
GO Cellular Component	anaphase-promoting complex	93	1.190357e-7	0.0000022117601032258062	3.54765	25	0.003118373	101	0.036755826059405944	1.969478	14	21	0.002202643	
GO Cellular Component	spliceosomal snRNP complex	94	1.606329e-7	0.000002952911182978723	2.269002	51	0.006361482	103	0.04892853809708737	1.524757	32	62	0.005034613	
GO Cellular Component	mitochondrial nucleoid	106	9.491365e-7	0.000015472715773584907	2.360071	41	0.005114132	69	0.001331526928695652	1.899139	27	42	0.004247955	
GO Cellular Component	mitochondrial small ribosomal subunit	141	0.00001119745	0.00013722832340425534	2.73202	25	0.003118373	81	0.0052316416	2.004647	19	28	0.002989301	
GO Cellular Component	cytosolic small ribosomal subunit	153	0.0000252256	0.0002849008941176471	2.069092	40	0.004989398	99	0.025503935999999998	1.678532	25	44	0.003933291	
GO Cellular Component	proteasome regulatory particle	197	0.0003453393	0.0030291690883248734	2.376252	21	0.002619434	101	0.036755826059405944	1.969478	14	21	0.002202643	
GO Molecular Function	structural constituent of ribosome	9	2.133216e-19	1.0007153279999999e-16	2.30207	148	0.01846077	11	0.000010053549221818181	1.622995	89	162	0.01400252	
GO Molecular Function	unfolded protein binding	22	1.572109e-12	3.01702009e-10	2.313815	90	0.01122614	64	0.0063066501021875	1.532848	55	106	0.008653241	
GO Molecular Function	ribonuclease activity	36	1.413198e-10	1.65736721e-8	2.077583	94	0.01172508	89	0.04334095523146067	1.462188	49	99	0.007709251	
GO Molecular Function	endoribonuclease activity	63	6.249169e-8	0.0000041879351615873014	2.240024	56	0.006985157	73	0.01674920030410959	1.688124	32	56	0.005034613	
GO Molecular Function	peptidyl-proline 4-dioxygenase activity	131	0.000007887178	0.00025419591996946565	3.125332	21	0.002619434	92	0.04964443289130435	2.62597	8	9	0.001258653	
GO Molecular Function	adenyl-nucleotide exchange factor activity	219	0.0001580179	0.00304635421826484	4.29525	10	0.001247349	92	0.04964443289130435	2.62597	8	9	0.001258653	
Human Phenotype	Exercise intolerance	12	2.150619e-12	1.1959233822499998e-9	2.643428	69	0.008606711	142	0.03778326378943662	1.561514	37	70	0.005821271	
Human Phenotype	Leukodystrophy	120	0.000002587054	0.00014386176118333333	2.073278	50	0.006236747	85	0.010555524112941176	1.77253	30	50	0.00471995	
Human Phenotype	Laryngomalacia	137	0.000006646386	0.0003237323633430657	2.753072	26	0.003243108	141	0.03778865474822695	2.32117	11	14	0.001730648	
Human Phenotype	Basal cell carcinoma	254	0.0001992293	0.005234083145275591	2.229014	26	0.003243108	149	0.04691562373825503	2.014239	15	22	0.002359975	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning, complete penetrance	56	5.90319e-15	9.65276979107143e-13	2.22885	119	0.01484346	81	0.030828645801234563	1.596874	40	74	0.006293266	
Mouse Phenotype Single KO	embryonic lethality between somite formation and embryo turning	72	2.161479e-13	2.7489810004166664e-11	2.05954	126	0.0157166	89	0.03528062461573034	1.525804	47	91	0.007394588	
Mouse Phenotype Single KO	abnormal branching of the mammary ductal tree	111	6.343742e-11	5.2333013958558555e-9	2.140634	91	0.01135088	78	0.024305648155128205	1.865821	24	38	0.00377596	
Mouse Phenotype	abnormal tricuspid valve cusp morphology	804	0.003740677	0.04448334925	2.324063	14	0.001746289	141	0.03445389754468085	2.954216	7	7	0.001101322