# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process negative regulation of gene expression, epigenetic 6 5.998782e-116 1.3156328723e-112 5.162521 310 0.02795563 590 0.03654921171355932 1.361807 60 114 0.008267879 GO Biological Process regulation of gene expression, epigenetic 9 1.895054e-99 2.7707795095555554e-96 2.990941 508 0.04581116 194 0.00003787822219793815 1.398048 134 248 0.01846493 GO Biological Process gene silencing 56 3.169487e-49 7.447728470178571e-47 2.682534 297 0.0267833 298 0.0009828973745302013 1.394339 97 180 0.0133664 GO Biological Process regulation of megakaryocyte differentiation 83 1.703937e-32 2.7014586726506022e-30 2.908214 169 0.01524033 310 0.0014831767835161293 1.600123 47 76 0.006476505 GO Biological Process multi-organism metabolic process 239 1.883482e-17 1.0370183948953976e-15 2.025332 177 0.01596176 413 0.008301175129782084 1.372924 78 147 0.01074824 GO Biological Process protein K63-linked ubiquitination 279 8.189434e-15 3.8625362726164873e-13 2.601799 87 0.007845613 529 0.026655905209829866 1.700313 23 35 0.003169354 GO Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 287 1.966646e-14 9.017106172125436e-13 2.122274 128 0.01154297 354 0.00376025487740113 1.447208 66 118 0.009094667 GO Biological Process regulation of histone methylation 297 5.950162e-14 2.636302416094276e-12 2.049119 134 0.01208405 591 0.036688071297800336 1.524737 33 56 0.004547334 GO Biological Process cotranslational protein targeting to membrane 331 3.79613e-13 1.50916237673716e-11 2.173854 109 0.009829561 430 0.010080268336046513 1.452131 55 98 0.007578889 GO Biological Process hepatocyte apoptotic process 411 1.101562e-11 3.526874539659367e-10 3.578593 41 0.003697358 622 0.043661625467845654 2.156194 10 12 0.00137798 GO Biological Process SRP-dependent cotranslational protein targeting to membrane 489 2.146036e-10 5.774987264621677e-9 2.044287 96 0.008657228 439 0.011241874582232346 1.462462 52 92 0.007165495 GO Biological Process vesicle cytoskeletal trafficking 557 1.145131e-9 2.7053462888689408e-8 2.105809 82 0.007394715 490 0.01834706734 1.646548 28 44 0.003858344 GO Biological Process gene silencing by miRNA 651 1.213163e-8 2.4522291731182794e-7 2.089159 73 0.0065831 490 0.01834706734 1.646548 28 44 0.003858344 GO Biological Process establishment or maintenance of cytoskeleton polarity 854 4.590762e-7 0.000007073751423653396 3.628207 22 0.001983948 459 0.014237344213943353 2.587433 8 8 0.001102384 GO Biological Process cellular response to growth hormone stimulus 886 7.188043e-7 0.000010675785308916478 2.013673 60 0.005410767 528 0.026324255509469697 1.940575 15 20 0.00206697 GO Biological Process negative regulation of mRNA processing 1114 0.000008107155 0.00009576485874775583 2.001732 49 0.004418793 600 0.038181123611666666 1.724955 20 30 0.00275596 GO Biological Process negative regulation of transforming growth factor beta production 1571 0.0002453023 0.002054699532590707 2.504855 20 0.001803589 459 0.014237344213943353 2.587433 8 8 0.001102384 GO Biological Process epithelial fluid transport 1919 0.001307285 0.008964337318916101 2.052886 23 0.002074128 459 0.014237344213943353 2.587433 8 8 0.001102384 GO Biological Process histone H3-K36 methylation 2295 0.004992569 0.02862623767799564 2.012238 18 0.00162323 552 0.030649885586956516 2.587433 7 7 0.0009645859 GO Cellular Component nucleosome 20 2.496344e-82 2.156841216e-80 5.404694 210 0.01893769 93 0.028717334709677418 1.379964 56 105 0.007716687 GO Cellular Component DNA packaging complex 21 9.33954e-72 7.6851072e-70 4.534392 217 0.01956894 96 0.031221198000000002 1.363023 59 112 0.008130081 GO Cellular Component protein-DNA complex 31 2.038682e-43 1.1364008051612903e-41 2.387964 323 0.02912796 77 0.014349260384415585 1.293716 101 202 0.0139176 GO Cellular Component RISC complex 316 0.0009302478 0.005086924678481012 2.195159 21 0.001893769 90 0.0240265152 2.32869 9 10 0.001240182 GO Molecular Function RNA polymerase core enzyme binding 42 7.101597e-13 7.138795841428572e-11 2.549599 77 0.006943818 94 0.04813008136170213 1.700313 23 35 0.003169354 GO Molecular Function histone methyltransferase activity 43 7.272237e-13 7.140322003255814e-11 2.005275 129 0.01163315 92 0.04684148380434783 1.534918 35 59 0.00482293 GO Molecular Function RNA polymerase binding 44 1.25e-12 1.1994318181818181e-10 2.203606 101 0.009108125 71 0.014668280526760563 1.655957 32 50 0.004409536 Mouse Phenotype Single KO abnormal erythropoiesis 9 3.181446e-46 3.2369445579999996e-43 2.441513 330 0.02975922 79 0.000003755896553037974 1.67007 71 110 0.009783657 Mouse Phenotype Single KO decreased erythrocyte cell number 12 3.371809e-43 2.5729712510833333e-40 2.097489 424 0.03823609 194 0.0008606650139690721 1.404606 95 175 0.01309081 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 40 5.122373e-30 1.172639239025e-27 2.011436 322 0.02903779 216 0.001482545855787037 1.389821 94 175 0.01295301 Mouse Phenotype Single KO abnormal platelet activation 42 1.770828e-29 3.8608266657142855e-27 2.497475 198 0.01785553 261 0.004458402962835249 1.522019 50 85 0.006889899 Mouse Phenotype Single KO abnormal platelet aggregation 44 1.20549e-28 2.508789075e-26 2.50511 191 0.01722428 243 0.003340964987983539 1.559094 47 78 0.006476505 Mouse Phenotype Single KO abnormal embryonic hematopoiesis 45 1.425607e-28 2.900951844222222e-26 2.515687 189 0.01704392 326 0.011749144459509203 1.611043 33 53 0.004547334 Mouse Phenotype Single KO decreased erythroid progenitor cell number 51 1.714217e-27 3.07785981745098e-25 2.489622 185 0.0166832 187 0.0006710249600000001 1.775689 35 51 0.00482293 Mouse Phenotype Single KO abnormal platelet physiology 67 7.701117e-25 1.0525243040149254e-22 2.11327 234 0.02110199 178 0.0005553545591011237 1.528938 65 110 0.008956869 Mouse Phenotype Single KO decreased platelet aggregation 72 7.348851e-23 9.34630952875e-21 2.624144 138 0.01244477 245 0.0034565839862448983 1.638707 38 60 0.005236324 Mouse Phenotype Single KO incomplete rostral neuropore closure 103 3.71306e-18 3.301018487378641e-16 2.007593 189 0.01704392 145 0.00013183225542068964 1.737828 45 67 0.006200909 Mouse Phenotype Single KO increased respiratory quotient 174 5.013985e-14 2.6386816462643675e-12 2.389986 96 0.008657228 385 0.026816452883116883 1.584143 30 49 0.00413394 Mouse Phenotype Single KO decreased inguinal fat pad weight 184 1.629939e-13 8.11160403423913e-12 2.711075 73 0.0065831 365 0.020870386032054794 1.820786 19 27 0.002618162 Mouse Phenotype Single KO abnormal interleukin-1 beta secretion 188 3.074517e-13 1.4975187323936168e-11 2.064331 124 0.01118225 399 0.029455888761904758 1.478533 40 70 0.00551192 Mouse Phenotype Single KO abnormal inguinal fat pad morphology 198 4.847331e-13 2.241768180151515e-11 2.139446 112 0.0101001 358 0.017649795214525137 1.604208 31 50 0.004271738 Mouse Phenotype Single KO polyploidy 226 4.314282e-12 1.7480477997345133e-10 2.693531 65 0.005861665 313 0.011309360163897764 1.890816 19 26 0.002618162 Mouse Phenotype Single KO absent hypoglossal nerve 278 1.035576e-10 3.4110681410071944e-9 3.661204 36 0.00324646 279 0.006057230781003584 2.242442 13 15 0.001791374 Mouse Phenotype Single KO increased susceptibility to weight loss 281 1.15909e-10 3.777148444839857e-9 2.390323 70 0.006312562 312 0.011139951284935896 1.703919 27 41 0.003720546 Mouse Phenotype Single KO abnormal body water content 310 3.31862e-10 9.802775270967742e-9 3.951553 31 0.002795563 448 0.04218349875669642 2.156194 10 12 0.00137798 Mouse Phenotype Single KO increased B cell derived lymphoma incidence 328 8.809488e-10 2.4594049273170734e-8 2.020242 92 0.00829651 428 0.03896913253504673 1.563241 29 48 0.003996142 Mouse Phenotype Single KO increased interleukin-1 beta secretion 330 1.055013e-9 2.9275012245454544e-8 2.311842 67 0.006042024 375 0.025134695229333332 1.724955 22 33 0.003031556 Mouse Phenotype abnormal erythropoiesis 10 1.650307e-48 1.5778585227e-45 2.3063 388 0.03498963 127 0.00000173058617007874 1.580244 91 149 0.01253962 Mouse Phenotype abnormal embryonic erythrocyte morphology 54 3.178826e-31 5.628288034444444e-29 3.222598 139 0.01253494 688 0.0437278310625 1.592266 24 39 0.003307152 Mouse Phenotype abnormal platelet aggregation 58 1.439198e-30 2.372443461724138e-28 2.482896 208 0.01875733 430 0.007990903697441862 1.458872 53 94 0.007303293 Mouse Phenotype abnormal platelet activation 63 6.079849e-30 9.226894649047618e-28 2.448371 209 0.01884751 557 0.021961719991023337 1.397214 54 100 0.007441091 Mouse Phenotype abnormal embryonic hematopoiesis 69 6.811499e-28 9.438368396956522e-26 2.379589 205 0.01848679 440 0.008781602490681818 1.569426 37 61 0.005098526 Mouse Phenotype abnormal platelet physiology 71 2.250646e-27 3.0307642825352112e-25 2.097475 264 0.02380738 246 0.0003004938349756098 1.489734 76 132 0.01047265 Mouse Phenotype decreased erythroid progenitor cell number 72 2.99379e-27 3.9755036375000003e-25 2.252133 224 0.0202002 262 0.00046896157614503814 1.634168 48 76 0.006614303 Mouse Phenotype early cellular replicative senescence 80 4.363436e-26 5.2148514495e-24 2.702993 151 0.0136171 364 0.003832976006868132 1.559549 44 73 0.006063111 Mouse Phenotype decreased platelet aggregation 90 1.359837e-23 1.4446001729999998e-21 2.552885 150 0.01352692 467 0.011224894483297646 1.509336 42 72 0.005787516 Mouse Phenotype abnormal cellular replicative senescence 92 2.501885e-22 2.6000567918478263e-20 2.439076 154 0.01388764 624 0.029806999740384612 1.416927 46 84 0.006338707 Mouse Phenotype abnormal liver sinusoid morphology 98 1.097022e-21 1.0702680961224489e-19 2.220078 181 0.01632248 457 0.010346612934354484 1.49275 45 78 0.006200909 Mouse Phenotype enlarged liver sinusoidal spaces 121 1.297866e-19 1.025528663305785e-17 2.610183 118 0.01064118 433 0.008381082068591224 1.703919 27 41 0.003720546 Mouse Phenotype increased circulating interleukin-1 beta level 131 1.159414e-18 8.461952102290077e-17 3.01883 88 0.007935792 618 0.029194745563106795 1.653082 23 36 0.003169354 Mouse Phenotype increased number of Howell-Jolly bodies 184 3.470222e-15 1.803195246847826e-13 3.589903 55 0.00495987 567 0.02271609287830688 2.069946 12 15 0.001653576 Mouse Phenotype increased respiratory quotient 194 8.523655e-15 4.2007559512886595e-13 2.312475 109 0.009829561 589 0.026747149105263157 1.524737 33 56 0.004547334 Mouse Phenotype increased susceptibility to weight loss 206 2.107713e-14 9.782448540291261e-13 2.401191 98 0.008837587 315 0.0014110236103809523 1.724955 34 51 0.004685132 Mouse Phenotype microcytic anemia 228 1.145826e-13 4.8049308710526314e-12 2.933692 65 0.005861665 395 0.0056485177746835435 1.873658 21 29 0.002893758 Mouse Phenotype polyploidy 244 3.542755e-13 1.3882082194672131e-11 2.687551 72 0.006492921 354 0.00327936628220339 1.897451 22 30 0.003031556 Mouse Phenotype decreased inguinal fat pad weight 300 2.486855e-11 7.925606885000001e-10 2.239714 86 0.007755433 413 0.006823310668038741 1.803362 23 33 0.003169354 Mouse Phenotype absent hypoglossal nerve 321 1.035576e-10 3.084467955140187e-9 3.661204 36 0.00324646 379 0.004655745347493403 2.242442 13 15 0.001791374