# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	18	6.264527e-29	4.5797172662777777e-26	2.705071	168	0.01867912	281	0.0008353010078647686	1.537916	63	113	0.009255178	
GO Biological Process	regulation of DNA-templated transcription in response to stress	27	2.295683e-25	1.118847873962963e-22	2.462567	173	0.01923505	273	0.0006910181331868132	1.529915	66	119	0.009695901	
GO Biological Process	nuclear-transcribed mRNA catabolic process	29	3.498679e-25	1.5875557572758622e-22	2.200616	216	0.02401601	205	0.000029852956731707318	1.476764	106	198	0.01557221	
GO Biological Process	rRNA processing	30	1.8544e-24	8.1340165333333335e-22	2.069896	241	0.02679564	151	0.0000011045743031125828	1.477759	135	252	0.01983253	
GO Biological Process	mRNA catabolic process	31	2.548717e-24	1.0818892581612902e-21	2.109717	229	0.02546142	211	0.00004608103436303318	1.45047	112	213	0.01645365	
GO Biological Process	rRNA metabolic process	34	1.144275e-23	4.428680801470588e-21	2.030044	244	0.0271292	152	0.000001193850275	1.469771	138	259	0.02027325	
GO Biological Process	endoplasmic reticulum unfolded protein response	49	1.201002e-20	3.225303126122449e-18	2.423674	143	0.01589949	562	0.0416118253113879	1.379242	57	114	0.008373733	
GO Biological Process	positive regulation of mRNA metabolic process	57	1.335081e-19	3.0821633121052635e-17	2.824139	103	0.01145208	372	0.0063643468126344084	1.697529	32	52	0.004701043	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	62	3.33733e-19	7.083213785483871e-17	3.451686	75	0.008338893	252	0.00035915929174206346	2.278748	19	23	0.002791244	
GO Biological Process	positive regulation of endoplasmic reticulum unfolded protein response	64	1.751121e-18	3.60046894359375e-16	3.782474	64	0.007115855	446	0.014544737114349775	2.334102	11	13	0.001615984	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	71	1.775771e-17	3.291178956197183e-15	2.541245	109	0.01211919	306	0.0015415415873202614	1.626798	46	78	0.006757749	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	96	5.106458e-16	6.999570918958333e-14	2.350871	115	0.0127863	239	0.00023248010805857744	1.566258	67	118	0.009842809	
GO Biological Process	mitochondrial translation	109	2.778621e-15	3.354483829266055e-13	2.385268	106	0.01178563	316	0.0020905728285443037	1.521033	59	107	0.008667548	
GO Biological Process	mitochondrial translational termination	113	4.206269e-15	4.898256085929203e-13	2.615358	88	0.009784301	396	0.007951076526515152	1.521922	48	87	0.007051565	
GO Biological Process	cellular response to epidermal growth factor stimulus	114	4.72088e-15	5.449303501754386e-13	2.475124	97	0.01078497	465	0.01889483264666667	1.7422	24	38	0.003525782	
GO Biological Process	RNA phosphodiester bond hydrolysis	121	1.031263e-14	1.121519819586777e-12	2.085958	136	0.01512119	258	0.0004340138612829457	1.514055	73	133	0.01072425	
GO Biological Process	mitochondrial translational elongation	124	1.212089e-14	1.2862805766935485e-12	2.598293	86	0.00956193	400	0.00849314428525	1.525279	47	85	0.006904657	
GO Biological Process	translational elongation	128	2.421018e-14	2.48891998921875e-12	2.262949	110	0.01223038	325	0.002489407473230769	1.502389	61	112	0.008961363	
GO Biological Process	protein targeting to ER	129	2.47919e-14	2.5289659852713177e-12	2.357209	101	0.01122971	263	0.0005704796753231939	1.58408	58	101	0.008520641	
GO Biological Process	response to epidermal growth factor	130	2.765405e-14	2.7992280303846155e-12	2.3645	100	0.01111852	458	0.01808959397882096	1.707633	26	42	0.003819597	
GO Cellular Component	PcG protein complex	34	1.023871e-17	5.203673788235294e-16	2.690236	100	0.01111852	116	0.023586336	1.61911	27	46	0.003966505	
GO Cellular Component	catalytic step 2 spliceosome	45	6.336884e-14	2.4333634560000002e-12	2.218935	111	0.01234156	72	0.00119274816	1.551647	54	96	0.00793301	
GO Cellular Component	spliceosomal snRNP complex	46	1.692105e-13	6.356429217391305e-12	2.776014	70	0.007782966	73	0.001231460146849315	1.690684	38	62	0.005582489	
GO Cellular Component	mitochondrial ribosome	47	7.955786e-13	2.925020895319149e-11	2.598648	74	0.008227707	111	0.01868090983783784	1.460374	45	85	0.006610842	
GO Cellular Component	U5 snRNP	50	4.404649e-12	1.5222466944e-10	4.113048	36	0.004002668	123	0.03272230712195122	1.880784	15	22	0.002203614	
GO Cellular Component	large ribosomal subunit	56	7.711343e-11	2.3795001257142857e-9	2.067201	98	0.01089615	71	0.0009019661070422536	1.511169	63	115	0.009255178	
GO Cellular Component	small nuclear ribonucleoprotein complex	61	1.876784e-10	5.316529101639344e-9	2.345127	71	0.007894152	95	0.00846808946526316	1.559143	39	69	0.005729396	
GO Cellular Component	endopeptidase complex	70	3.430481e-9	8.468387382857144e-8	2.182744	71	0.007894152	124	0.032788340129032256	1.479187	37	69	0.005435581	
GO Cellular Component	retromer complex	72	6.73465e-9	1.616316e-7	2.903888	40	0.004447409	84	0.004632192	2.101702	16	21	0.002350522	
GO Cellular Component	proteasome complex	78	1.627229e-8	3.604938092307693e-7	2.122457	69	0.007671781	139	0.0442632421294964	1.460374	36	68	0.005288673	
GO Cellular Component	U2 snRNP	86	4.820412e-8	9.685665041860463e-7	3.610912	26	0.002890816	69	0.000613599276521739	2.322934	16	19	0.002350522	
GO Cellular Component	prespliceosome	92	1.10593e-7	0.0000020772250434782607	3.272743	28	0.003113187	108	0.017825888	1.970346	15	21	0.002203614	
GO Cellular Component	Fanconi anaemia nuclear complex	100	1.712376e-7	0.000002958985728	2.926647	32	0.003557928	135	0.043386457600000004	2.121911	10	13	0.001469076	
GO Cellular Component	U2-type prespliceosome	103	2.006208e-7	0.0000033657547805825244	3.55757	24	0.002668446	120	0.0266028336	2.068863	12	16	0.001762891	
GO Cellular Component	proteasome regulatory particle, base subcomplex	125	0.000001941797	0.000026843401728	4.576562	15	0.001667779	109	0.018412125357798164	2.298737	10	12	0.001469076	
GO Cellular Component	endoplasmic reticulum chaperone complex	137	0.000004185022	0.00005278626289051095	4.290028	15	0.001667779	129	0.03615466269767442	2.256941	9	11	0.001322168	
GO Cellular Component	proteasome regulatory particle	139	0.00000543655	0.00006758531223021581	2.723303	27	0.003002001	84	0.004632192	2.101702	16	21	0.002350522	
GO Cellular Component	proteasome accessory complex	142	0.000006274877	0.0000763590665915493	2.701186	27	0.003002001	125	0.03284644608	1.838989	16	24	0.002350522	
GO Cellular Component	nuclear proteasome complex	145	0.000008271011	0.00009856763453793102	5.008727	12	0.001334223	91	0.0056493598945054945	2.758484	8	8	0.001175261	
GO Cellular Component	U1 snRNP	166	0.00003059484	0.00031848122602409643	2.567051	25	0.002779631	105	0.016541699657142857	2.032567	14	19	0.002056706	
GO Molecular Function	unfolded protein binding	10	3.184241e-21	1.3443865502e-18	2.727044	119	0.01323104	29	0.00000641568131862069	1.717547	66	106	0.009695901	
GO Molecular Function	structural constituent of ribosome	17	2.274086e-14	5.647759465882353e-12	2.010406	145	0.01612186	51	0.000334870661882353	1.481408	87	162	0.01278096	
GO Molecular Function	rRNA binding	18	3.662711e-14	8.591092134444444e-12	3.253823	58	0.006448744	45	0.0001505375679111111	1.838989	40	60	0.005876304	
GO Molecular Function	NF-kappaB binding	23	7.413697e-12	1.3608969014782609e-9	3.13303	50	0.005559262	97	0.029061066265979384	1.871828	19	28	0.002791244	
GO Molecular Function	ribonuclease activity	25	3.39397e-11	5.7317365360000004e-9	2.04891	104	0.01156326	84	0.01620476982380952	1.476764	53	99	0.007786103	
GO Molecular Function	endoribonuclease activity	49	1.023667e-7	0.000008820249130612245	2.139316	60	0.006671114	108	0.04458580551851852	1.576277	32	56	0.004701043	
GO Molecular Function	DNA-directed 5'-3' RNA polymerase activity	89	0.000006110573	0.0002898745978202247	2.25938	38	0.004225039	87	0.01733618228505747	1.732071	27	43	0.003966505	
GO Molecular Function	5'-3' RNA polymerase activity	110	0.00001234278	0.0004737383378181818	2.18728	38	0.004225039	105	0.040031094047619044	1.65509	27	45	0.003966505	
GO Molecular Function	5S rRNA binding	122	0.00001976551	0.0006840162559016394	3.750688	15	0.001667779	83	0.014650604510843374	2.507713	10	11	0.001469076	
GO Molecular Function	mismatched DNA binding	173	0.0001571655	0.0038355649768786124	2.972169	16	0.001778964	109	0.04498610721100917	2.298737	10	12	0.001469076	
Human Phenotype	Increased serum lactate	17	1.378468e-14	5.410892331764706e-12	2.28337	110	0.01223038	31	0.0002389575469032258	1.65509	60	100	0.008814456	
Human Phenotype	Abnormal isoelectric focusing of serum transferrin	134	0.000006952367	0.0003462174999328358	2.885024	24	0.002668446	90	0.035527000098888886	2.068863	15	20	0.002203614	
Mouse Phenotype Single KO	pale liver	15	6.595826e-22	4.026531912133333e-19	2.576263	136	0.01512119	144	0.029782322185416668	1.517166	44	80	0.006463934	
Mouse Phenotype	pale liver	40	2.304281e-16	5.507807660249999e-14	2.003719	169	0.0187903	153	0.008889467854901962	1.47955	59	110	0.008667548	
Mouse Phenotype	abnormal vitelline vein morphology	180	8.624441e-8	0.000004581015577833334	2.135069	61	0.006782299	241	0.04933575180497925	1.875769	17	25	0.002497429	
Mouse Phenotype	decreased mitochondrial DNA content	307	0.00001467198	0.00045693420449511397	2.430454	30	0.003335557	224	0.036859067808482145	2.109429	13	17	0.001909799	
Mouse Phenotype	abnormal mitophagy	558	0.001164081	0.0199458395	2.547456	15	0.001667779	219	0.03585184653150685	2.758484	7	7	0.001028353