# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	21	1.83767e-45	1.1515190252380951e-42	2.744575	264	0.0189519	446	0.0011963192102466367	1.420072	72	113	0.008545994	
GO Biological Process	regulation of DNA-templated transcription in response to stress	22	1.88682e-44	1.1285756536363637e-41	2.600939	283	0.02031587	387	0.00033268621202842374	1.442116	77	119	0.009139466	
GO Biological Process	mRNA catabolic process	28	7.879857e-41	3.7032513665357146e-38	2.183014	367	0.02634602	185	4.072471504108108e-8	1.464889	140	213	0.01661721	
GO Biological Process	RNA catabolic process	32	2.996874e-40	1.2323707801875e-37	2.07375	407	0.02921752	166	1.1528829786144578e-8	1.451907	157	241	0.01863501	
GO Biological Process	nuclear-transcribed mRNA catabolic process	34	1.711809e-38	6.625204303235295e-36	2.2102	336	0.0241206	197	7.126072758375636e-8	1.47456	131	198	0.01554896	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	38	2.46475e-37	8.535169802631578e-35	2.768937	212	0.01521895	490	0.0023740970980612244	1.400349	71	113	0.0084273	
GO Biological Process	rRNA processing	39	8.26325e-36	2.7881053012820517e-33	2.0518	370	0.02656138	189	5.287988013333333e-8	1.423907	161	252	0.01910979	
GO Biological Process	rRNA metabolic process	43	2.369826e-35	7.252218682325581e-33	2.025157	377	0.02706389	187	4.539181568823529e-8	1.419843	165	259	0.01958457	
GO Biological Process	regulation of mRNA stability	52	3.073247e-32	7.777087937115385e-30	2.071648	324	0.02325915	393	0.00040490276483460554	1.387418	94	151	0.01115727	
GO Biological Process	regulation of hematopoietic stem cell differentiation	54	4.090394e-32	9.967684193703704e-30	2.733212	185	0.01328069	591	0.006785962706091371	1.384838	64	103	0.007596439	
GO Biological Process	multi-organism metabolic process	60	1.425414e-31	3.126170471e-29	2.295434	252	0.01809045	169	1.3233780494674556e-8	1.576784	104	147	0.01234421	
GO Biological Process	mRNA transport	61	1.672406e-31	3.6077361563934425e-29	2.183573	280	0.0201005	290	0.000012300121145172415	1.465462	96	146	0.01139466	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	65	7.413582e-31	1.500851162123077e-28	2.709532	180	0.01292175	486	0.0022389009606995887	1.485816	52	78	0.006172107	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	67	1.468531e-30	2.8842387207462688e-28	2.573756	195	0.01399856	275	0.0000069870653330909086	1.529887	81	118	0.009614243	
GO Biological Process	viral gene expression	75	2.19201e-29	3.845954612e-27	2.450501	205	0.01471644	222	4.388329707747748e-7	1.561862	89	127	0.0105638	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	77	3.815154e-29	6.519949543636363e-27	2.055493	297	0.02132089	394	0.00044462958459390864	1.380371	96	155	0.01139466	
GO Biological Process	ribonucleoprotein complex export from nucleus	83	1.088292e-28	1.725401738313253e-26	2.389117	210	0.01507538	297	0.000016250026946801346	1.497703	84	125	0.009970326	
GO Biological Process	ribonucleoprotein complex localization	84	1.185821e-28	1.8576450641666666e-26	2.359506	215	0.01543431	278	0.000007495816078057554	1.509215	86	127	0.01020772	
GO Biological Process	viral transcription	94	3.45526e-26	4.836996419148936e-24	2.412321	187	0.01342426	253	0.000003133530825019763	1.558135	79	113	0.009376855	
GO Biological Process	mRNA export from nucleus	96	5.405082e-26	7.408903545625e-24	2.436174	182	0.01306533	329	0.000052995652668693006	1.51385	72	106	0.008545994	
GO Cellular Component	ribosomal subunit	38	2.445376e-28	1.1120025599999998e-26	2.144031	261	0.01873654	52	1.7677134276923076e-7	1.469753	122	185	0.01448071	
GO Cellular Component	large ribosomal subunit	43	2.611021e-23	1.0492661134883722e-21	2.356159	173	0.01241924	57	0.00000598396092631579	1.531037	79	115	0.009376855	
GO Cellular Component	catalytic step 2 spliceosome	44	3.534886e-23	1.388246138181818e-21	2.310342	179	0.01284996	99	0.0013248125672727271	1.439384	62	96	0.00735905	
GO Cellular Component	very-low-density lipoprotein particle	57	4.45152e-19	1.3495134315789473e-17	4.002212	62	0.004450826	115	0.0039625323965217394	1.894415	17	20	0.002017804	
GO Cellular Component	mitochondrial large ribosomal subunit	58	7.404828e-19	2.2061280662068967e-17	3.16619	83	0.005958363	109	0.0028329180770642203	1.573217	36	51	0.004272997	
GO Cellular Component	host cell	66	4.809528e-17	1.2592218763636364e-15	2.276847	132	0.009475951	129	0.010195829581395349	1.442116	44	68	0.005222552	
GO Cellular Component	mitochondrial ribosome	67	4.880835e-17	1.2588183402985074e-15	2.494079	110	0.007896626	119	0.005798028100840336	1.415895	54	85	0.006409496	
GO Cellular Component	high-density lipoprotein particle	68	8.730546e-17	2.2185858070588232e-15	3.815703	57	0.004091888	124	0.007143051716129033	1.733452	21	27	0.002492582	
GO Cellular Component	proteasome core complex	69	1.722529e-16	4.313811756521739e-15	4.531428	46	0.003302225	156	0.029820129230769227	1.671543	18	24	0.002136499	
GO Cellular Component	other organism cell	73	3.208832e-15	7.595700953424658e-14	2.143224	133	0.009547739	167	0.042940603401197604	1.355305	45	74	0.005341246	
GO Cellular Component	DNA packaging complex	75	7.560624e-15	1.7419677695999998e-13	2.145805	129	0.009260589	161	0.03642592874534161	1.293456	65	112	0.007715134	
GO Cellular Component	endopeptidase complex	77	2.072203e-14	4.650346472727273e-13	2.242976	113	0.008111989	71	0.00007411594005633803	1.615017	50	69	0.005934718	
GO Cellular Component	plasma lipoprotein particle	80	3.710393e-14	8.01444888e-13	2.403907	96	0.006891601	137	0.014526602277372262	1.560107	28	40	0.003323442	
GO Cellular Component	proteasome complex	81	1.020774e-13	2.1776511999999996e-12	2.204522	111	0.007968413	75	0.00011447870976	1.605992	49	68	0.005816024	
GO Cellular Component	protein-lipid complex	82	1.751386e-13	3.690725619512196e-12	2.326842	97	0.006963388	142	0.01619115312676056	1.538881	29	42	0.003442136	
GO Cellular Component	cytoplasmic stress granule	119	1.152226e-9	1.673148342857143e-8	2.027273	90	0.006460876	91	0.00039325956923076926	1.710416	33	43	0.003916914	
GO Cellular Component	spliceosomal snRNP complex	125	2.821885e-9	3.900973824e-8	2.074008	81	0.005814788	159	0.03467372196226415	1.401939	39	62	0.00462908	
GO Cellular Component	prespliceosome	225	0.000008897052	0.00006832935936	2.414936	32	0.0022972	162	0.038271914666666663	1.698075	16	21	0.00189911	
GO Cellular Component	U2-type prespliceosome	235	0.00001360371	0.00010003068459574468	2.584091	27	0.001938263	125	0.0074935660032	1.950134	14	16	0.001661721	
GO Cellular Component	U1 snRNP	246	0.0000191162	0.0001342796487804878	2.254111	34	0.002440775	155	0.02953314766451613	1.759519	15	19	0.001780415	
GO Molecular Function	protease binding	9	5.415321e-25	2.5403872513333334e-22	2.040249	257	0.01844939	59	0.0004781129478305085	1.429105	84	131	0.009970326	
GO Molecular Function	unfolded protein binding	10	4.05396e-21	1.7115819120000002e-18	2.337782	158	0.01134243	103	0.009296475087378641	1.387696	66	106	0.007833828	
GO Molecular Function	ribonuclease activity	12	2.399377e-18	8.441808078333334e-16	2.124261	167	0.01198851	84	0.0028131653435714285	1.440791	64	99	0.007596439	
GO Molecular Function	exonuclease activity	33	1.940736e-13	2.4829658763636365e-11	2.034014	131	0.009404164	130	0.032277131541538454	1.407615	48	76	0.005697329	
GO Molecular Function	sterol transporter activity	58	1.75613e-11	1.2783415275862069e-9	2.380637	77	0.005527638	115	0.01462723648173913	1.708688	23	30	0.00272997	
GO Molecular Function	endoribonuclease activity	62	1.946162e-10	1.3252735425806452e-8	2.094917	91	0.006532663	134	0.03484145635820895	1.47255	37	56	0.004391691	
GO Molecular Function	lipoprotein particle receptor binding	66	4.151662e-10	2.6558056006060607e-8	2.178836	80	0.005743001	58	0.0003427273285862069	1.971564	23	26	0.00272997	
GO Molecular Function	aminoacyl-tRNA editing activity	159	0.000001388885	0.000036879701069182386	3.012577	26	0.001866475	77	0.001629586175844156	2.228724	13	13	0.001543027	
Human Phenotype	Hypoglycemia	3	4.591994e-22	1.0214125320666666e-18	2.032484	227	0.01629576	200	0.0246656801565	1.341179	68	113	0.008071217	
Human Phenotype	Increased serum lactate	8	8.732842e-21	7.28428183325e-18	2.251618	168	0.0120603	91	0.00046644240668131874	1.493245	67	100	0.007952522	
Human Phenotype	Exercise intolerance	10	1.185759e-18	7.912569807000001e-16	2.557627	116	0.008327351	206	0.026538371991262136	1.432751	45	70	0.005341246	
Human Phenotype	Abnormality of transition element cation homeostasis	20	7.85275e-16	2.6200700375000003e-13	3.672532	56	0.004020101	194	0.023722432447422684	1.690756	22	29	0.002611276	
Human Phenotype	Abnormality of mitochondrial metabolism	21	1.017977e-15	3.2347431052380953e-13	2.207411	129	0.009260589	118	0.0016274270742372883	1.550417	48	69	0.005697329	
Human Phenotype	Abnormality of the mitochondrion	24	2.398251e-15	6.66813705125e-13	2.173579	130	0.009332376	119	0.0018649745260504202	1.538133	49	71	0.005816024	
Human Phenotype	Abnormal CSF metabolite level	34	2.674209e-14	5.2485284285294124e-12	2.392596	98	0.007035176	217	0.0295449166078341	1.450439	41	63	0.004866469	
Human Phenotype	Nephrotic syndrome	36	5.906982e-14	1.0949247468333334e-11	2.082941	129	0.009260589	167	0.009681532039520959	1.57868	34	48	0.004035608	
Human Phenotype	Increased CSF lactate	38	1.371304e-13	2.4080819978947366e-11	2.426297	90	0.006460876	234	0.03448671989316239	1.460199	38	58	0.004510386	
Human Phenotype	Abnormality of reticulocytes	44	3.422615e-12	5.190706794318182e-10	2.639939	68	0.004881551	226	0.03260103007964602	1.62089	24	33	0.002848665	
Human Phenotype	Chromosomal breakage induced by crosslinking agents	53	3.564643e-11	4.4880873092452835e-9	3.998687	34	0.002440775	250	0.043765778027999996	2.228724	8	8	0.0009495549	
Human Phenotype	Leukodystrophy	66	3.39606e-10	3.4336224818181816e-8	2.100057	88	0.006317301	115	0.0015845073315652175	1.649256	37	50	0.004391691	
Human Phenotype	Progressive macrocephaly	80	1.415914e-9	1.18104926525e-7	2.851662	45	0.003230438	192	0.02255888282083333	1.764407	19	24	0.002255193	
Human Phenotype	Acute encephalopathy	92	8.308183e-9	6.026141865108696e-7	2.478011	52	0.00373295	149	0.005592802526845637	1.85727	20	24	0.002373887	
Human Phenotype	Abnormal mitochondria in muscle tissue	99	1.447723e-8	9.75823795858586e-7	2.74074	42	0.003015075	227	0.034095002682819384	1.744219	18	23	0.002136499	
Human Phenotype	Acute necrotizing encephalopathy	105	2.020706e-8	0.000001284206775047619	2.787211	40	0.0028715	243	0.0402524147489712	1.782979	16	20	0.00189911	
Human Phenotype	Overgrowth	135	1.756209e-7	0.000008680876042222222	2.561498	40	0.0028715	243	0.0402524147489712	1.782979	16	20	0.00189911	
Mouse Phenotype Single KO	pale liver	27	1.757593e-17	5.960844111481482e-15	2.066997	169	0.01213209	194	0.010437058918041238	1.448671	52	80	0.006172107	
Mouse Phenotype Single KO	abnormal cellular replicative senescence	83	4.64214e-12	5.121454937349398e-10	2.084441	109	0.007824838	190	0.009784360528421052	1.522961	41	60	0.004866469	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	146	1.152608e-9	7.229062641095891e-8	2.606163	53	0.003804738	238	0.024973185858823528	1.764407	19	24	0.002255193	
Mouse Phenotype Single KO	abnormal oxidative phosphorylation	156	2.090382e-9	1.2270274342307692e-7	2.146002	76	0.005455851	166	0.005774999956626507	1.671543	30	40	0.003560831	
Mouse Phenotype Single KO	increased hepatocyte proliferation	234	6.495073e-8	0.0000025416830538888886	2.52621	44	0.00315865	259	0.03694591406949807	2.042997	11	12	0.001305638	
Mouse Phenotype	abnormal cellular replicative senescence	31	1.105484e-19	3.4095266206451615e-17	2.168574	172	0.01234745	165	0.00012682637527272728	1.565413	59	84	0.007002967	
Mouse Phenotype	early cellular replicative senescence	32	2.759153e-19	8.2438318228125e-17	2.237221	157	0.01127064	185	0.00023178747804324324	1.587584	52	73	0.006172107	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	44	3.04967e-17	6.626794288636364e-15	3.143479	76	0.005455851	272	0.003158195847132353	1.782979	24	30	0.002848665	
Mouse Phenotype	dry eyes	180	5.202149e-11	2.7632081438333332e-9	2.494073	67	0.004809763	371	0.013969608025067385	1.950134	14	16	0.001661721	
Mouse Phenotype	decreased liver cholesterol level	236	1.028643e-9	4.1673117470338985e-8	2.111761	82	0.005886576	289	0.004286398106574395	1.741191	25	32	0.002967359	
Mouse Phenotype	decreased brain cholesterol level	434	0.000001584994	0.00003491734477880184	2.63344	32	0.0022972	337	0.009354720715727002	2.228724	10	10	0.001186944	
Mouse Phenotype	increased urine uric acid level	514	0.000006398325	0.00011901631386186772	2.346584	35	0.002512563	491	0.04183739767209776	2.026113	10	11	0.001186944