# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	28	2.102068e-53	9.878968861428571e-51	2.455958	382	0.01695893	471	0.0005560546385138005	1.279804	93	113	0.007701863	
GO Biological Process	regulation of DNA-templated transcription in response to stress	36	4.922111e-48	1.7991682958055556e-45	2.273474	400	0.01775805	441	0.00033815914650793646	1.280614	98	119	0.008115942	
GO Biological Process	nuclear-transcribed mRNA catabolic process	47	4.106926e-44	1.1498518985957445e-41	2.001445	492	0.0218424	168	2.0076592307142855e-9	1.327274	169	198	0.01399586	
GO Biological Process	endoplasmic reticulum unfolded protein response	50	1.517505e-43	3.9937696590000003e-41	2.328009	344	0.01527192	460	0.0004406946239347826	1.282219	94	114	0.007784679	
GO Biological Process	IRE1-mediated unfolded protein response	70	1.770318e-39	3.3279449374285715e-37	3.02359	196	0.008701443	835	0.02608629128502994	1.286922	48	58	0.003975155	
GO Biological Process	cellular response to unfolded protein	82	1.253586e-36	2.011699777317073e-34	2.121558	352	0.01562708	418	0.00021325009483253587	1.28515	100	121	0.008281573	
GO Biological Process	cellular response to topologically incorrect protein	89	5.817019e-36	8.600691350674157e-34	2.047457	376	0.01669256	682	0.0085259669313783	1.208226	108	139	0.008944099	
GO Biological Process	positive regulation of nuclease activity	90	8.928068e-36	1.3053827423555555e-33	4.700696	102	0.004528302	808	0.021596166452970297	1.555031	15	15	0.001242236	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	95	4.264861e-34	5.907505884105263e-32	2.277316	279	0.01238624	227	2.2490278776651983e-7	1.370536	104	118	0.008612836	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	102	1.917799e-32	2.4741487295098038e-30	2.336586	251	0.01114317	524	0.0014521066995419848	1.315796	66	78	0.005465839	
GO Biological Process	cellular response to epidermal growth factor stimulus	104	2.555822e-32	3.233852086346154e-30	2.404503	236	0.01047725	683	0.008570333394582722	1.391344	34	38	0.002815735	
GO Biological Process	response to epidermal growth factor	117	4.337011e-31	4.877839978547009e-29	2.313095	245	0.0108768	696	0.009541615478591954	1.369908	37	42	0.003064182	
GO Biological Process	regulation of mitochondrial membrane permeability	122	1.6098e-30	1.7363408360655737e-28	2.187344	271	0.01203108	314	0.000013080079526114648	1.405918	66	73	0.005465839	
GO Biological Process	mitochondrial transmembrane transport	143	2.50541e-28	2.3055028104895106e-26	2.251593	235	0.01043285	399	0.00012995696480200503	1.348943	72	83	0.005962733	
GO Biological Process	cotranslational protein targeting to membrane	153	3.274674e-27	2.8164336709803926e-25	2.238547	228	0.01012209	211	8.917112157345972e-8	1.412222	89	98	0.0073706	
GO Biological Process	liver regeneration	157	5.74166e-27	4.812388785987261e-25	2.601036	168	0.00745838	797	0.020048619820577165	1.377313	31	35	0.002567288	
GO Biological Process	regulation of membrane permeability	161	7.027967e-27	5.744162593354037e-25	2.022989	285	0.01265261	324	0.00001897950187654321	1.38225	72	81	0.005962733	
GO Biological Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay	163	1.760163e-26	1.420980669754601e-24	2.250225	219	0.009722531	785	0.018971891862420383	1.276518	55	67	0.004554865	
GO Biological Process	platelet-derived growth factor receptor signaling pathway	164	2.114615e-26	1.696720657621951e-24	2.210241	227	0.01007769	550	0.0020266197432909088	1.460787	31	33	0.002567288	
GO Biological Process	viral gene expression	165	2.704047e-26	2.1565184529090907e-24	2.032919	275	0.01220866	225	2.0873010495555555e-7	1.359122	111	127	0.009192547	
GO Cellular Component	mitochondrial ribosome	58	1.690081e-21	5.035275806896552e-20	2.313597	165	0.007325194	67	0.000013952307868656715	1.372086	75	85	0.00621118	
GO Cellular Component	mitochondrial large ribosomal subunit	90	2.467616e-15	4.7378227199999993e-14	2.429866	103	0.004572697	110	0.0017425497600000001	1.372086	45	51	0.003726708	
GO Cellular Component	mitochondrial nucleoid	147	1.808906e-10	2.12638746122449e-9	2.028259	99	0.004395117	89	0.0003807500440449438	1.443957	39	42	0.003229814	
GO Cellular Component	small-subunit processome	159	2.643538e-9	2.8729771471698116e-8	2.123083	77	0.003418424	142	0.014776626929577466	1.377313	31	35	0.002567288	
GO Cellular Component	mitochondrial small ribosomal subunit	247	7.536533e-7	0.000005272521872064777	2.100317	54	0.002397336	164	0.031074487024390245	1.388421	25	28	0.002070393	
GO Cellular Component	aminoacyl-tRNA synthetase multienzyme complex	379	0.0003242214	0.0014782442722955146	2.005124	31	0.001376249	182	0.047397539868131874	1.555031	12	12	0.0009937888	
GO Molecular Function	unfolded protein binding	11	4.210135e-32	1.615926360909091e-29	2.315014	253	0.01123196	92	0.0052133164217391306	1.261629	86	106	0.007122153	
GO Molecular Function	rRNA binding	37	2.880082e-16	3.286407082162162e-14	2.441634	109	0.004839068	63	0.0003682753426984127	1.399528	54	60	0.00447205	
Human Phenotype	Abnormal CSF metabolite level	7	3.190438e-24	3.0413989677142857e-21	2.47613	164	0.007280799	174	0.016278054839080458	1.308201	53	63	0.004389234	
Human Phenotype	Increased CSF lactate	14	6.864228e-22	3.271785246e-19	2.467457	148	0.006570477	234	0.047204260175213675	1.286922	48	58	0.003975155	
Human Phenotype	Abnormality of mitochondrial metabolism	20	8.703053e-20	2.9037736334499995e-17	2.063547	195	0.008657048	93	0.0015618421984946237	1.352201	60	69	0.004968944	
Human Phenotype	Abnormality of the mitochondrion	26	4.391657e-19	1.1271356600384615e-16	2.02663	196	0.008701443	107	0.0026238223527102803	1.336013	61	71	0.00505176	
Human Phenotype	Increased serum ferritin	36	3.541541e-16	6.564639748055556e-14	3.503186	61	0.002708102	237	0.049634674995780594	1.47728	19	20	0.001573499	
Human Phenotype	Death in infancy	38	2.3896e-15	4.1962633684210526e-13	2.037048	152	0.006748058	165	0.012921536536363635	1.332884	48	56	0.003975155	
Human Phenotype	Abnormality of transition element cation homeostasis	39	2.540948e-15	4.34762718051282e-13	2.960648	73	0.003240844	171	0.015145196893567251	1.447788	27	29	0.002236025	
Human Phenotype	Aplasia/hypoplasia of the femur	67	4.366553e-13	4.3489564431343286e-11	2.121768	115	0.005105438	183	0.018962281222950822	1.413665	30	33	0.002484472	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	171	1.220199e-14	6.534129966666666e-13	2.538291	90	0.00399556	307	0.023714342241368078	1.484348	21	22	0.00173913	
Mouse Phenotype Single KO	increased incidence of tumors by ionizing radiation induction	652	0.000001722626	0.00002419338386809816	2.304583	41	0.0018202	342	0.035505223280701756	1.555031	15	15	0.001242236	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	175	2.684094e-17	1.4664355848e-15	2.135613	155	0.006881243	593	0.04755023885160202	1.388421	25	28	0.002070393	
Mouse Phenotype	absent segment of posterior cerebral artery	224	1.220199e-14	5.208179749553571e-13	2.538291	90	0.00399556	420	0.018098820479285713	1.484348	21	22	0.00173913	
Mouse Phenotype	abnormal cerebral artery morphology	367	1.533686e-10	3.9955236637602175e-9	2.096884	92	0.004084351	574	0.04119986476829269	1.425445	22	24	0.001821946	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	841	0.000003492752	0.000039707731120095134	2.069187	49	0.002175361	315	0.00686994879904762	1.555031	19	19	0.001573499	
Mouse Phenotype	abnormal level of surface class I molecules	1391	0.0007912941	0.00543893809496765	2.178182	22	0.0009766926	545	0.0361901919412844	1.555031	14	14	0.00115942