# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process nucleosome organization 75 9.788104e-11 1.7173554738133335e-8 2.125812 90 0.02234359 396 0.042783796886363634 1.478601 53 171 0.01346545 GO Biological Process regulation of transcription from RNA polymerase II promoter in response to stress 78 1.849609e-10 3.12038523474359e-8 2.408839 67 0.01663357 389 0.03955632610539846 1.604266 38 113 0.009654472 GO Biological Process regulation of DNA-templated transcription in response to stress 89 8.15068e-10 1.2051100912359552e-7 2.256648 71 0.01762661 361 0.03245140260969529 1.603556 40 119 0.0101626 GO Biological Process protein localization to endoplasmic reticulum 96 2.002062e-9 2.744284776875e-7 2.354245 62 0.01539225 327 0.02265139153180428 1.615841 42 124 0.01067073 GO Biological Process regulation of megakaryocyte differentiation 162 3.2662e-7 0.00002653081839506173 2.273966 48 0.01191658 182 0.0017623754707142857 2.008665 32 76 0.008130081 GO Biological Process positive regulation of transcription from RNA polymerase II promoter in response to stress 192 0.000001509622 0.00010346414530208334 3.365403 22 0.005461768 412 0.04791587947572815 2.38529 12 24 0.00304878 GO Biological Process cellular response to glucose starvation 199 0.000001835991 0.00012140605813567838 2.56554 33 0.008192651 331 0.022977005435045317 2.191888 17 37 0.004319106 GO Biological Process placenta blood vessel development 213 0.000003002488 0.00018549173517370891 2.547448 32 0.007944389 239 0.008603288129707114 2.462234 16 31 0.004065041 GO Biological Process purine ribonucleoside biosynthetic process 238 0.000005578966 0.0003084605613193277 2.080619 46 0.01142006 385 0.03805606725454545 1.699862 31 87 0.007876016 GO Biological Process beta-catenin-TCF complex assembly 256 0.00001361578 0.000699883003984375 2.125786 40 0.009930487 319 0.021208797558307207 2.10793 19 43 0.004827236 GO Biological Process regulation of transforming growth factor beta2 production 297 0.00004072328 0.0018043018232996636 3.345998 16 0.003972195 423 0.04965201787470449 3.577934 6 8 0.00152439 GO Biological Process establishment of epithelial cell polarity 379 0.0001534044 0.005326249339313984 2.03992 33 0.008192651 339 0.023763869153687316 2.38529 14 28 0.003556911 GO Biological Process positive regulation of mRNA catabolic process 500 0.0005907853 0.0155482875254 2.226272 22 0.005461768 332 0.023444439046987953 2.480701 13 25 0.003302846 GO Biological Process labyrinthine layer blood vessel development 513 0.0006435586 0.016507968065107213 2.314111 20 0.004965243 409 0.046724874244498775 2.498875 11 21 0.002794715 GO Biological Process pericyte cell differentiation 530 0.0006958751 0.017277397058301888 3.294691 11 0.002730884 225 0.006767650306222222 4.174257 7 8 0.001778455 GO Biological Process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 581 0.001065329 0.02412851000172117 2.332985 18 0.004468719 292 0.016638253119520545 2.981612 10 16 0.00254065 GO Biological Process synapse maturation 594 0.001159675 0.02569051064814815 2.913768 12 0.002979146 317 0.020166375055205046 4.089068 6 7 0.00152439 GO Biological Process regulation of Golgi organization 615 0.001311658 0.028065215645528455 2.731056 13 0.003227408 245 0.009160694245714284 3.180386 10 15 0.00254065 GO Biological Process commissural neuron axon guidance 633 0.001439387 0.029922422642969983 2.406469 16 0.003972195 423 0.04965201787470449 3.577934 6 8 0.00152439 GO Biological Process mesangial cell differentiation 655 0.001587776 0.03189854104427481 3.168202 10 0.002482622 317 0.020166375055205046 4.089068 6 7 0.00152439 GO Cellular Component SWI/SNF superfamily-type complex 47 0.000001263985 0.00004647161872340426 2.144203 49 0.01216485 56 0.02903587097142857 1.788967 27 72 0.006859756 GO Molecular Function chromatin DNA binding 8 2.650401e-15 1.39874912775e-12 2.662519 86 0.02135055 34 0.00023573400405882354 1.972451 43 104 0.0109248 GO Molecular Function nucleosomal DNA binding 9 1.526339e-13 7.160225842222222e-11 3.939004 43 0.01067527 49 0.013003044844897959 2.177873 21 46 0.005335366 GO Molecular Function nucleosome binding 10 1.823452e-13 7.698614344e-11 3.156204 57 0.01415094 38 0.000776013488368421 2.168445 30 66 0.007621951 GO Molecular Function structure-specific DNA binding 11 1.417359e-11 5.440081543636364e-9 2.108956 100 0.02482622 37 0.0006927516936216216 1.784677 52 139 0.01321138 Human Phenotype Foot dorsiflexor weakness 20 0.000006792397 0.00226628325905 2.406074 33 0.008192651 23 0.046923520543478266 2.266025 19 40 0.004827236 Mouse Phenotype Single KO abnormal cellular replicative senescence 1 1.174377e-19 1.0753770189e-15 4.100307 62 0.01539225 131 0.005376242461832061 2.067251 26 60 0.006605691 Mouse Phenotype Single KO lordosis 18 6.457778e-8 0.00003285215174777777 2.882787 35 0.008689176 229 0.024541575732751092 2.308345 15 31 0.003810976 Mouse Phenotype Single KO delayed cellular replicative senescence 23 2.405639e-7 0.0000957758101 7.090715 12 0.002979146 293 0.04988155427645052 3.577934 6 8 0.00152439 Mouse Phenotype Single KO abnormal liver sinusoid morphology 35 0.000001220681 0.00031936502619999996 2.166614 48 0.01191658 272 0.040761173544117645 1.807038 25 66 0.006351626 Mouse Phenotype Single KO persistent right dorsal aorta 49 0.00000319992 0.0005979932130612245 2.802646 27 0.006703078 124 0.005174585253548387 3.407557 10 14 0.00254065 Mouse Phenotype Single KO abnormal fourth pharyngeal arch artery morphology 80 0.00001293335 0.001480383574375 2.403244 31 0.007696127 196 0.017249036228061225 2.981612 10 16 0.00254065 Mouse Phenotype Single KO abnormal fourth pharyngeal arch morphology 139 0.0001160391 0.007644388767625899 2.099165 32 0.007944389 281 0.0473255267544484 2.498875 11 21 0.002794715 Mouse Phenotype Single KO abnormal sixth pharyngeal arch artery morphology 235 0.0006759849 0.026340398848085107 2.048575 26 0.006454816 58 0.00023576022686206896 3.64809 13 17 0.003302846 Mouse Phenotype abnormal cellular replicative senescence 1 4.250732e-19 4.0641248652e-15 3.357363 77 0.01911619 158 0.0008235131350632912 1.987741 35 84 0.008892276 Mouse Phenotype early cellular replicative senescence 2 5.237061e-17 2.50357701105e-13 3.351041 68 0.01688183 270 0.007035136067777777 1.895162 29 73 0.007367886 Mouse Phenotype enlarged liver sinusoidal spaces 7 1.492975e-9 0.000002039190567857143 2.801236 46 0.01142006 358 0.021026807584357543 2.094401 18 41 0.004573171 Mouse Phenotype abnormal somatic mesoderm morphology 8 2.372088e-9 0.000002834941671 53.98325 6 0.001489573 452 0.04079031428761062 4.770579 4 4 0.00101626 Mouse Phenotype abnormal liver sinusoid morphology 21 2.554905e-8 0.000011632117478571426 2.161089 64 0.01588878 292 0.00995339064349315 1.834838 30 78 0.007621951 Mouse Phenotype delayed cellular replicative senescence 28 1.202183e-7 0.00004105025593928572 6.815433 13 0.003227408 396 0.028029254553030302 3.339405 7 10 0.001778455 Mouse Phenotype decreased follicular B cell number 57 0.000003726202 0.0006250213565263158 2.025654 51 0.01266137 342 0.01794780855789474 1.766881 30 81 0.007621951 Mouse Phenotype increased squamous cell carcinoma incidence 70 0.000005261107 0.0007185920575285714 2.192958 41 0.01017875 393 0.02747150209160305 1.92658 21 52 0.005335366 Mouse Phenotype persistent right dorsal aorta 97 0.00002190543 0.0021591527446391755 2.460917 28 0.006951341 243 0.00463810405308642 3.086845 11 17 0.002794715 Mouse Phenotype abnormal neuron specification 145 0.00008891852 0.005863103239448276 2.445556 24 0.005958292 320 0.014128749823125 2.761914 11 19 0.002794715 Mouse Phenotype sporadic seizures 170 0.0001456422 0.008191088671764707 2.129949 30 0.007447865 405 0.030637764155555552 2.120257 16 36 0.004065041 Mouse Phenotype penis prolapse 265 0.0006136076 0.02213849910792453 5.959736 6 0.001489573 452 0.04079031428761062 4.770579 4 4 0.00101626 Mouse Phenotype decreased heart iron level 268 0.0006754259 0.02409607100708955 7.387146 5 0.001241311 452 0.04079031428761062 4.770579 4 4 0.00101626 Mouse Phenotype decreased mesenchymal cell proliferation involved in lung development 327 0.00127758 0.03735456385321101 2.360328 17 0.004220457 242 0.00436903722892562 3.816463 8 10 0.00203252