# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process citrate transport 67 1.179254e-7 0.000023160900576119404 14.68177 8 0.002780674 438 0.03559966159360731 5.387948 4 4 0.001147776 GO Biological Process positive T cell selection 127 0.000004219138 0.00043716249560629916 3.054915 23 0.007994439 328 0.011530433333841463 2.811103 12 23 0.003443329 GO Biological Process negative regulation of heart contraction 280 0.0001644301 0.007727627449642857 2.394418 23 0.007994439 178 0.0006225226452865168 3.279621 14 23 0.004017217 GO Biological Process T cell selection 281 0.0001661578 0.007781033772953737 2.111629 30 0.01042753 296 0.008366029856756756 2.410398 17 38 0.004878049 GO Biological Process positive thymic T cell selection 327 0.0003092403 0.01244432143027523 3.93988 10 0.003475843 396 0.02683337090580808 4.040961 6 8 0.001721664 GO Biological Process negative regulation of heart rate 452 0.0009211519 0.026817340380752213 2.841885 13 0.004518596 273 0.006494058082783883 3.918508 8 11 0.002295552 Mouse Phenotype Single KO increased body temperature 4 2.287006e-11 5.2355284855e-8 4.162164 33 0.01147028 312 0.038313797830128206 2.285796 14 33 0.004017217 Mouse Phenotype Single KO abnormal body temperature 18 1.378326e-8 0.000007011850656666666 2.21092 63 0.02189781 45 0.000058626247728888886 2.165744 41 102 0.01176471 Mouse Phenotype Single KO increased B cell apoptosis 39 9.170436e-7 0.0002153171344923077 3.07611 26 0.009037192 194 0.013565883095360824 2.811103 12 23 0.003443329 Mouse Phenotype Single KO abnormal B cell apoptosis 54 0.000003063371 0.0005194683008703704 2.500299 33 0.01147028 192 0.013176942077083332 2.348593 17 39 0.004878049 Mouse Phenotype Single KO hyporesponsive to tactile stimuli 63 0.000005517729 0.000801997531 2.357054 35 0.01216545 278 0.030760988226258997 2.21044 16 39 0.004591105 Mouse Phenotype Single KO increased metanephric mesenchyme apoptosis 70 0.000007102718 0.0009291369818 2.62139 28 0.00973236 180 0.010648293758333333 3.463681 9 14 0.002582496 Mouse Phenotype Single KO abnormal midbrain size 224 0.0006590768 0.02694270650714286 2.162038 23 0.007994439 304 0.03560834997697369 2.486745 12 26 0.003443329 Mouse Phenotype Single KO decreased molar number 230 0.0007399065 0.029457929654347823 3.072617 12 0.004171011 255 0.028997500627843138 4.040961 6 8 0.001721664 Mouse Phenotype increased body temperature 5 6.92209e-12 1.3236420498e-8 3.939482 37 0.01286062 417 0.017841419836690648 2.309121 15 35 0.004304161 Mouse Phenotype extramedullary hematopoiesis 14 6.745246e-10 4.606521214714285e-7 2.037668 90 0.03128259 587 0.0404286803560477 1.477837 48 175 0.01377331 Mouse Phenotype small ureteric bud 63 0.000002323139 0.00035256399966666663 5.684158 12 0.004171011 472 0.02400260691101695 5.387948 4 4 0.001147776 Mouse Phenotype increased metanephric mesenchyme apoptosis 67 0.00000308359 0.00044003289537313434 2.459993 34 0.01181787 118 0.0005134333163898306 3.502166 13 20 0.003730273 Mouse Phenotype hyporesponsive to tactile stimuli 102 0.00001646278 0.0015431435252941177 2.128543 39 0.01355579 340 0.012839309424705883 2.112921 20 51 0.005738881 Mouse Phenotype abnormal Meibomian gland morphology 150 0.00008985645 0.005727450123 2.224291 29 0.01007994 412 0.017749632160922332 2.586215 12 25 0.003443329 Mouse Phenotype abnormal ureteric bud elongation 161 0.0001146892 0.006810828827329192 2.352869 25 0.008689607 89 0.0001874911025730337 3.591966 14 21 0.004017217 Mouse Phenotype abnormal skin sebaceous gland morphology 181 0.0001666317 0.008802020351933702 2.111268 30 0.01042753 567 0.036914902962962966 2.259462 13 31 0.003730273 Mouse Phenotype abnormal midbrain size 273 0.0008500446 0.029770243298901097 2.014244 26 0.009037192 539 0.032712012495361785 2.218567 14 34 0.004017217 Mouse Phenotype increased curvature of hairs 276 0.000867958 0.030067197239130438 3.015261 12 0.004171011 552 0.0353466879076087 3.591966 6 9 0.001721664 Mouse Phenotype abnormal transitional stage T2 B cell morphology 304 0.001223433 0.038477772740131574 2.30245 18 0.006256517 296 0.008399894071621622 2.601079 14 29 0.004017217 Mouse Phenotype decreased molar number 357 0.001858275 0.04976741533613445 2.750283 12 0.004171011 552 0.0353466879076087 3.591966 6 9 0.001721664