# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	4	5.07503e-34	1.6695579942500002e-30	2.775738	191	0.01916708	236	0.00002330508525042373	1.616467	69	113	0.009727901	
GO Biological Process	regulation of DNA-templated transcription in response to stress	7	2.627176e-31	4.938715569142858e-28	2.569494	200	0.02007025	226	0.000008719502753982301	1.623948	73	119	0.01029184	
GO Biological Process	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	10	1.510836e-30	1.9881090924e-27	9.979365	47	0.004716508	504	0.011117357651785714	2.406598	10	11	0.001409841	
GO Biological Process	mitochondrial transport	11	4.651352e-30	5.564285542545455e-27	2.03674	312	0.03130958	110	1.4647438415454547e-10	1.595001	144	239	0.02030171	
GO Biological Process	cellular response to topologically incorrect protein	16	1.10859e-26	9.11745988125e-24	2.3879	194	0.01946814	285	0.00017121950588421054	1.504557	79	139	0.01113774	
GO Biological Process	regulation of hematopoietic progenitor cell differentiation	19	4.769558e-26	3.303295459052632e-23	2.720428	149	0.01495233	473	0.00901027888731501	1.429051	61	113	0.008600028	
GO Biological Process	endoplasmic reticulum unfolded protein response	21	1.004563e-25	6.294783103333334e-23	2.539345	166	0.0166583	245	0.000035943169348571426	1.602288	69	114	0.009727901	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	23	1.512576e-25	8.653907645217391e-23	2.176787	225	0.02257903	238	0.000027874748402941173	1.520038	89	155	0.01254758	
GO Biological Process	response to topologically incorrect protein	26	2.269584e-24	1.148671379076923e-21	2.113107	229	0.02298043	251	0.00004584730335577689	1.470699	100	180	0.01409841	
GO Biological Process	regulation of hematopoietic stem cell differentiation	28	3.142192e-24	1.476718018857143e-21	2.767453	134	0.01344706	446	0.006264675350672645	1.464987	57	103	0.008036092	
GO Biological Process	mRNA catabolic process	34	5.682129e-23	2.1991510444411766e-20	2.01224	242	0.024285	196	0.0000017141155095918368	1.491413	120	213	0.01691809	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	7.115513e-23	2.600917654638889e-20	2.068943	225	0.02257903	230	0.000014545363584347827	1.470699	110	198	0.01550825	
GO Biological Process	cellular response to unfolded protein	39	2.937388e-22	9.911048382564103e-20	2.316054	170	0.01705971	275	0.0001132659250218182	1.55335	71	121	0.01000987	
GO Biological Process	mitochondrial membrane organization	42	9.574308e-22	2.9997218802857147e-19	2.144052	196	0.01966884	138	3.8262395693478266e-9	1.771955	83	124	0.01170168	
GO Biological Process	IRE1-mediated unfolded protein response	43	1.262683e-21	3.8641036272093027e-19	3.242928	93	0.009332664	427	0.004586506274473067	1.643126	36	58	0.005075426	
GO Biological Process	translational elongation	45	1.421467e-21	4.156685389555555e-19	2.543772	137	0.01374812	402	0.0037068411992537314	1.465446	62	112	0.008741012	
GO Biological Process	response to unfolded protein	48	3.398216e-20	9.316067571666666e-18	2.038525	204	0.02047165	246	0.00003605211348902439	1.505628	91	160	0.01282955	
GO Biological Process	gene silencing	51	1.631342e-19	4.2091822309803924e-17	2.020226	201	0.0201706	368	0.0018776881044293477	1.382457	94	180	0.0132525	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	55	2.83993e-19	6.794661612727272e-17	2.546132	121	0.0121425	360	0.00167281484675	1.595143	47	78	0.006626251	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	60	3.63239e-18	7.966436668333333e-16	2.380106	129	0.01294531	491	0.010433929222403259	1.413366	63	118	0.008881996	
GO Cellular Component	mitochondrial ribosome	35	1.931071e-20	9.533973394285714e-19	3.042724	96	0.009633718	164	0.0326186236097561	1.401489	45	85	0.006344283	
GO Cellular Component	ribosomal subunit	36	3.269129e-20	1.5691819200000002e-18	2.124399	185	0.01856498	91	0.002082315956043956	1.359403	95	185	0.01339349	
GO Cellular Component	large ribosomal subunit	40	1.195301e-17	5.16370032e-16	2.37981	125	0.0125439	174	0.0369179155862069	1.335139	58	115	0.008177076	
GO Cellular Component	chromosome, telomeric region	41	5.800679e-17	2.4447739785365855e-15	2.036669	169	0.01695936	55	9.754358923636363e-7	1.553481	98	167	0.01381644	
GO Cellular Component	peptidase complex	43	1.228597e-16	4.9372456186046505e-15	2.380952	117	0.01174109	76	0.00035547552	1.594371	53	88	0.007472156	
GO Cellular Component	endopeptidase complex	52	6.966528e-14	2.315030843076923e-12	2.469506	89	0.008931259	101	0.00361864415049505	1.573008	41	69	0.005780347	
GO Cellular Component	nuclear chromosome, telomeric region	54	1.75353e-13	5.611296e-12	2.035128	131	0.01314601	63	0.000034136969142857145	1.544234	77	132	0.01085577	
GO Cellular Component	proteasome complex	56	1.023545e-12	3.158367428571429e-11	2.387612	86	0.008630206	110	0.00531482688	1.557211	40	68	0.005639363	
GO Cellular Component	cytoplasmic exosome (RNase complex)	66	2.589088e-11	6.778703127272728e-10	6.324199	22	0.002207727	123	0.010446149151219513	2.239987	11	13	0.001550825	
GO Cellular Component	mitochondrial nucleoid	75	1.232548e-9	2.8397905920000005e-8	2.547056	55	0.005519318	93	0.0025481422451612903	1.764839	28	42	0.003947554	
GO Cellular Component	ESCRT complex	76	2.518284e-9	5.725782568421053e-8	3.012103	40	0.004014049	108	0.004974784	1.890898	20	28	0.002819681	
GO Cellular Component	host cell	78	4.048406e-9	8.968776369230769e-8	2.025411	84	0.008429503	78	0.0003975995076923077	1.674001	43	68	0.006062315	
GO Cellular Component	proteasome accessory complex	83	7.465e-9	1.5541590361445783e-7	3.160343	35	0.003512293	103	0.0039029832699029126	1.985443	18	24	0.002537713	
GO Cellular Component	proteasome regulatory particle	91	1.977255e-8	3.754611692307692e-7	3.095185	34	0.003411942	86	0.0013328723051162792	2.143018	17	21	0.002396729	
GO Cellular Component	cytoplasmic stress granule	107	1.471166e-7	0.0000023758643439252335	2.046713	65	0.00652283	125	0.0105115802112	1.662232	27	43	0.00380657	
GO Cellular Component	DNA-directed RNA polymerase III complex	110	2.906933e-7	0.000004566527476363637	3.876903	21	0.002107376	136	0.020429712	1.950611	14	19	0.001973777	
GO Cellular Component	transcription factor TFIIIC complex	118	6.522665e-7	0.000009551834847457626	5.857598	13	0.001304566	161	0.031143593739130435	2.647258	6	6	0.0008459044	
GO Cellular Component	prespliceosome	137	0.000002446015	0.00003085192642335767	2.848349	27	0.002709483	140	0.022425181714285713	1.890898	15	21	0.002114761	
GO Cellular Component	pre-autophagosomal structure membrane	145	0.000005922198	0.00007057626306206896	2.772222	26	0.002609132	155	0.031037076232258064	1.985443	12	16	0.001691809	
GO Cellular Component	Cul4-RING E3 ubiquitin ligase complex	158	0.00001714062	0.0001874619706329114	2.129775	39	0.003913698	176	0.03863057890909091	1.654536	20	32	0.002819681	
GO Molecular Function	unfolded protein binding	8	1.612897e-17	8.5120639175e-15	2.440634	118	0.01184145	111	0.02164995576396396	1.423525	57	106	0.008036092	
GO Molecular Function	ribonuclease activity	15	1.788932e-12	5.035247269333334e-10	2.062639	116	0.01164074	119	0.03550251416806722	1.417219	53	99	0.007472156	
GO Molecular Function	protein phosphatase activator activity	35	9.176386e-9	0.000001106934334057143	3.418455	31	0.003110888	100	0.01746147426	2.647258	8	8	0.001127873	
GO Molecular Function	RNA polymerase III activity	95	0.000006557609	0.0002914339494526316	3.546525	18	0.001806322	106	0.019454741001886794	2.150897	13	16	0.001832793	
GO Molecular Function	telomeric DNA binding	143	0.00003380611	0.0009981076672727273	2.021292	41	0.0041144	99	0.016798207868686868	1.790792	23	34	0.003242634	
GO Molecular Function	sphingolipid transporter activity	195	0.0001658382	0.003590609643076923	3.646931	12	0.001204215	122	0.0379126602295082	2.647258	7	7	0.0009868885	
GO Molecular Function	mismatch repair complex binding	381	0.003235951	0.03585875360104987	2.701247	11	0.001103864	100	0.01746147426	2.647258	8	8	0.001127873	
Human Phenotype	Increased serum lactate	1	1.16737e-15	7.789860010000001e-12	2.266964	121	0.0121425	29	0.00017235505316206897	1.6413	62	100	0.008741012	
Human Phenotype	Abnormal CSF metabolite level	20	1.176189e-10	3.9243545985e-8	2.388995	70	0.007024586	105	0.03702090791142857	1.554739	37	63	0.005216411	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	47	2.38585e-8	0.0000033873993723404257	3.745381	26	0.002609132	67	0.009928097367761195	2.206048	15	18	0.002114761	
Mouse Phenotype	Meibomian gland atrophy	4	2.747429e-29	6.56704216725e-26	10.71221	43	0.004315103	287	0.03649616924738676	2.647258	7	7	0.0009868885	
Mouse Phenotype	abnormal cellular replicative senescence	33	1.465462e-12	4.2458430854545456e-10	2.06208	117	0.01174109	32	4.5175635365625e-7	1.859383	59	84	0.00831806	
Mouse Phenotype	decreased hematopoietic stem cell proliferation	81	3.610472e-8	0.000004261694171851852	6.876887	14	0.001404917	287	0.03649616924738676	2.647258	7	7	0.0009868885	
Mouse Phenotype	decreased DN4 thymocyte number	175	0.000005202278	0.00028422274261714285	2.019948	50	0.005017561	323	0.047594658	1.950611	14	19	0.001973777	
Mouse Phenotype	abnormal copper homeostasis	231	0.0000298136	0.001233973288311688	3.15655	18	0.001806322	268	0.026526876771268658	2.239987	11	13	0.001550825	
Mouse Phenotype	abnormal copper level	274	0.00008354948	0.0029153889718248173	3.017488	17	0.001705971	327	0.0491797665412844	2.206048	10	12	0.001409841