# GREAT version 4.0.4 Species assembly: hg38 Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included # Ontology Term Name Binom Rank Binom Raw P-Value Binom FDR Q-Val Binom Fold Enrichment Binom Observed Region Hits Binom Region Set Coverage Hyper Rank Hyper FDR Q-Val Hyper Fold Enrichment Hyper Observed Gene Hits Hyper Total Genes Hyper Gene Set Coverage GO Biological Process positive regulation of CD4-positive, alpha-beta T cell activation 15 2.248765e-25 1.9727665756666667e-22 4.860836 68 0.0205252 112 0.0000638130901125 3.243005 18 30 0.005181347 GO Biological Process regulation of immune effector process 17 9.303977e-25 7.201825490764706e-22 2.258966 196 0.05916088 171 0.0005034967376959064 1.508027 101 362 0.02907311 GO Biological Process regulation of T cell activation 22 1.984768e-23 1.1871619141818183e-20 2.111792 214 0.06459402 48 0.0000013803969194791666 1.737324 99 308 0.02849741 GO Biological Process regulation of CD4-positive, alpha-beta T cell activation 25 3.456324e-23 1.8192707006400003e-20 3.959837 77 0.02324177 123 0.0000804753836691057 2.702504 24 48 0.006908463 GO Biological Process regulation of adaptive immune response 29 1.271982e-22 5.771727978620689e-20 2.950764 111 0.03350438 190 0.0007749736795789474 1.856682 45 131 0.01295337 GO Biological Process positive regulation of CD4-positive, alpha-beta T cell differentiation 34 3.204313e-22 1.2401633755e-19 5.226594 55 0.01660127 185 0.0006838533136756757 3.118274 15 26 0.004317789 GO Biological Process positive regulation of T cell activation 40 1.270659e-21 4.18015044525e-19 2.342499 158 0.04769091 122 0.00007996933549672131 1.774779 66 201 0.01899827 GO Biological Process regulation of regulatory T cell differentiation 46 7.772466e-21 2.2234321759565218e-18 5.260719 51 0.0153939 403 0.024244265679900744 2.594404 12 25 0.003454231 GO Biological Process positive regulation of leukocyte cell-cell adhesion 50 6.463064e-20 1.7009491835200002e-17 2.217865 162 0.04889828 95 0.00002517092304421053 1.80167 70 210 0.02014968 GO Biological Process negative regulation of immune response 53 1.206265e-19 2.9949511575471696e-17 2.863015 100 0.03018412 334 0.011227621263473054 1.702365 40 127 0.0115141 GO Biological Process regulation of CD4-positive, alpha-beta T cell differentiation 57 3.419735e-19 7.894788221929825e-17 4.003548 62 0.01871416 218 0.0016398015415137615 2.567379 19 40 0.0054692 GO Biological Process positive regulation of leukocyte differentiation 65 1.934213e-18 3.915739825692307e-16 2.381676 129 0.03893752 166 0.0004614295304457832 1.883564 46 132 0.01324122 GO Biological Process positive regulation of hemopoiesis 81 1.558736e-17 2.5322724720987652e-15 2.20559 143 0.0431633 180 0.0005908350060888889 1.768912 54 165 0.01554404 GO Biological Process positive regulation of T cell differentiation 84 2.647459e-17 4.147370592976191e-15 2.865533 87 0.02626019 203 0.0012103829703448276 2.147195 29 73 0.008347726 GO Biological Process regulation of alpha-beta T cell activation 85 2.968031e-17 4.594861168117647e-15 2.924575 84 0.02535466 240 0.002488997983708333 2.062438 29 76 0.008347726 GO Biological Process regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 89 4.659018e-17 6.888541332808989e-15 2.741881 92 0.02776939 308 0.006967831489285714 1.756628 39 120 0.01122625 GO Biological Process positive regulation of alpha-beta T cell activation 95 1.53891e-16 2.1316333357894734e-14 3.238614 69 0.02082704 425 0.029446934635058822 2.053903 19 50 0.0054692 GO Biological Process negative regulation of immune effector process 102 3.134807e-16 4.044208364019608e-14 2.91366 79 0.02384546 381 0.01878606125065617 1.733682 34 106 0.009786989 GO Biological Process positive regulation of immune effector process 110 1.052341e-15 1.258886838090909e-13 2.341563 112 0.03380622 312 0.007584223391025642 1.621503 51 170 0.01468048 GO Biological Process regulation of T cell differentiation 116 1.854445e-15 2.1036760133620693e-13 2.311284 113 0.03410806 284 0.00505227758028169 1.758773 41 126 0.01180196 GO Cellular Component melanosome 65 3.79777e-7 0.000010096225476923077 2.048388 60 0.01811047 32 0.024191136000000002 1.750193 34 105 0.009786989 GO Cellular Component protein serine/threonine phosphatase complex 84 0.00001166714 0.00024000973714285716 2.163538 39 0.01177181 35 0.03513859364571429 2.09582 19 49 0.0054692 GO Molecular Function 1-phosphatidylinositol binding 89 0.00004134015 0.0019611023966292136 2.635167 23 0.006942348 42 0.04285306879523809 3.243005 9 15 0.002590674 Mouse Phenotype Single KO abnormal T cell physiology 6 3.177631e-47 4.849594511166667e-44 2.341864 350 0.1056444 45 2.492777551777778e-7 1.575174 153 525 0.04404145 Mouse Phenotype Single KO abnormal T cell activation 22 5.053639e-41 2.103462378318182e-38 2.74879 230 0.06942348 106 0.00008877322759433961 1.627113 87 289 0.02504318 Mouse Phenotype Single KO abnormal cytokine secretion 26 4.733626e-39 1.6671466646923077e-36 2.205328 327 0.09870208 89 0.000029110658593258425 1.457743 154 571 0.0443293 Mouse Phenotype Single KO abnormal erythropoiesis 30 7.311604e-38 2.2317452609333334e-35 3.590741 145 0.04376698 23 3.111756822217391e-8 2.456822 50 110 0.01439263 Mouse Phenotype Single KO abnormal T cell proliferation 32 3.911675e-36 1.11935024921875e-33 2.701772 208 0.06278298 153 0.0005654190146405228 1.594581 77 261 0.02216465 Mouse Phenotype Single KO decreased T cell proliferation 37 2.602892e-32 6.441805957837838e-30 3.129101 148 0.0446725 171 0.0011745089498245613 1.765636 49 150 0.01410478 Mouse Phenotype Single KO altered susceptibility to autoimmune disorder 39 1.936741e-31 4.5473685479487177e-29 2.723368 178 0.05372774 121 0.0001899540188429752 1.635999 79 261 0.02274036 Mouse Phenotype Single KO abnormal interleukin secretion 40 4.044398e-31 9.2586381215e-29 2.228306 255 0.07696951 152 0.0005661744785592105 1.461163 113 418 0.03252735 Mouse Phenotype Single KO abnormal granulocyte morphology 41 1.125828e-30 2.514440730731707e-28 2.121964 279 0.0842137 60 0.000001469661872 1.579386 135 462 0.0388601 Mouse Phenotype Single KO abnormal granulocyte number 43 2.702837e-30 5.755785676511628e-28 2.156352 266 0.08028977 71 0.000004152449294647888 1.574395 127 436 0.03655728 Mouse Phenotype Single KO autoimmune response 48 3.86693e-26 7.376974585416666e-24 2.347223 192 0.05795352 242 0.003709078040123967 1.45331 89 331 0.02561888 Mouse Phenotype Single KO abnormal self tolerance 50 4.888334e-26 8.952494887600002e-24 2.330111 194 0.0585572 223 0.0030197864261883407 1.460813 90 333 0.02590674 Mouse Phenotype Single KO abnormal immune tolerance 51 5.340086e-26 9.588072059215686e-24 2.322284 195 0.05885904 225 0.0031871398384888893 1.455195 91 338 0.02619459 Mouse Phenotype Single KO decreased susceptibility to autoimmune disorder 53 9.716327e-25 1.6787246479056605e-22 3.017599 118 0.03561727 355 0.01847589576 1.56812 47 162 0.01352907 Mouse Phenotype Single KO abnormal neutrophil cell number 63 7.711506e-23 1.120861276857143e-20 2.37456 163 0.04920012 95 0.00004817764698842106 1.673939 83 268 0.02389177 Mouse Phenotype Single KO decreased erythrocyte cell number 68 4.573616e-22 6.158912016470589e-20 2.450567 148 0.0446725 202 0.0023352779778217825 1.667831 54 175 0.01554404 Mouse Phenotype Single KO decreased myeloid cell number 73 3.382244e-21 4.242631275068493e-19 2.039384 209 0.06308482 140 0.00039693129150714286 1.559478 88 305 0.02533103 Mouse Phenotype Single KO abnormal CD4-positive, alpha-beta T cell physiology 74 1.248503e-20 1.5449381041891891e-18 2.74243 113 0.03410806 307 0.01059286830651466 1.632385 45 149 0.01295337 Mouse Phenotype Single KO abnormal mean corpuscular hemoglobin 75 1.420296e-20 1.7340867295999998e-18 2.592644 124 0.03742831 202 0.0023352779778217825 1.667831 54 175 0.01554404 Mouse Phenotype Single KO decreased erythroid progenitor cell number 77 1.816195e-20 2.159856833116883e-18 3.513397 78 0.02354362 102 0.00006438581160392156 2.649514 25 51 0.007196315 Mouse Phenotype abnormal T cell physiology 19 1.16242e-43 5.8494198e-41 2.068689 418 0.1261696 61 7.238656610655738e-8 1.506568 194 696 0.05584341 Mouse Phenotype abnormal T cell activation 25 1.705682e-39 6.5232102408e-37 2.369115 287 0.08662843 128 0.000023554509478124997 1.546176 117 409 0.03367876 Mouse Phenotype abnormal erythropoiesis 31 1.014984e-36 3.130407104516129e-34 3.223072 162 0.04889828 59 7.3880780120339e-8 2.176514 60 149 0.01727116 Mouse Phenotype abnormal T cell proliferation 36 1.495251e-35 3.9711374475e-33 2.390068 254 0.07666767 231 0.0005768846645454546 1.48344 101 368 0.02907311 Mouse Phenotype decreased T cell proliferation 41 6.492291e-32 1.5139705914878048e-29 2.659959 188 0.05674615 150 0.000046982014616 1.750918 69 213 0.01986183 Mouse Phenotype altered susceptibility to autoimmune disorder 45 7.778353e-31 1.6526407340666666e-28 2.455275 209 0.06308482 193 0.00018397786450259065 1.544288 96 336 0.02763385 Mouse Phenotype decreased inflammatory response 47 2.918286e-30 5.936538818297873e-28 2.633673 181 0.05463326 419 0.013274211731026251 1.413893 79 302 0.02274036 Mouse Phenotype abnormal interleukin secretion 50 9.297512e-29 1.77787024464e-26 2.001569 299 0.09025053 265 0.0010997202909056604 1.376368 137 538 0.03943581 Mouse Phenotype increased myeloid cell number 52 9.273259e-28 1.7050313326730769e-25 2.309345 211 0.0636885 220 0.0004341453230318182 1.563121 83 287 0.02389177 Mouse Phenotype abnormal erythrocyte cell number 56 1.479599e-25 2.5261510783928569e-23 2.112331 234 0.07063085 125 0.000019845117552000002 1.635273 95 314 0.027346 Mouse Phenotype decreased susceptibility to autoimmune disorder 58 3.171824e-25 5.228587804137931e-23 2.829552 133 0.04014488 424 0.013402039296933963 1.510223 57 204 0.0164076 Mouse Phenotype decreased erythrocyte cell number 61 1.660667e-24 2.6028913421311475e-22 2.344067 180 0.05433142 157 0.00006267491271974523 1.708076 73 231 0.02101324 Mouse Phenotype autoimmune response 73 3.654876e-23 4.7868862241095885e-21 2.029172 232 0.07002717 213 0.00033693255767605634 1.462532 115 425 0.03310305 Mouse Phenotype abnormal self tolerance 74 3.890928e-23 5.027184136216216e-21 2.020875 234 0.07063085 205 0.0002619824534487805 1.46834 116 427 0.0333909 Mouse Phenotype abnormal immune tolerance 75 5.112019e-23 6.516801821200001e-21 2.012842 235 0.07093269 217 0.00037464333494930877 1.453761 117 435 0.03367876 Mouse Phenotype decreased erythroid progenitor cell number 76 7.049661e-23 8.868659055394737e-21 3.264289 97 0.0292786 117 0.000010676564405128205 2.41803 34 76 0.009786989 Mouse Phenotype anemia 77 7.871868e-23 9.774406486753247e-21 2.002304 236 0.07123453 81 4.529992357037037e-7 1.670903 115 372 0.03310305 Mouse Phenotype abnormal mean corpuscular hemoglobin 80 1.043727e-22 1.2473842308749998e-20 2.611584 136 0.04105041 230 0.0005731349763913044 1.703753 58 184 0.01669545 Mouse Phenotype abnormal acute inflammation 86 3.105368e-21 3.4523748195348834e-19 2.208299 175 0.05282222 613 0.04079538326427406 1.335166 83 336 0.02389177 Mouse Phenotype extramedullary hematopoiesis 87 5.309906e-21 5.835403593793104e-19 2.555952 130 0.03923936 203 0.00025513194100492613 1.760489 57 175 0.0164076