# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	14	1.253357e-79	1.1780660545e-76	2.740093	473	0.01797522	370	0.000018432373224864868	1.299184	100	114	0.007887679	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	17	2.207413e-76	1.7086675098235295e-73	2.647162	481	0.01827924	240	2.6440241627083334e-8	1.363108	104	113	0.008203187	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	21	2.195433e-72	1.3757001355714286e-69	2.260523	617	0.02344759	486	0.0004771139316872428	1.223077	128	155	0.01009623	
GO Biological Process	cellular response to topologically incorrect protein	23	1.555805e-69	8.901233910869566e-67	2.414541	518	0.01968534	382	0.0000292759778513089	1.267966	119	139	0.009386339	
GO Biological Process	cellular response to unfolded protein	25	1.759002e-68	9.258682927200001e-66	2.486779	482	0.01831725	386	0.00003094998504533679	1.285226	105	121	0.008282063	
GO Biological Process	IRE1-mediated unfolded protein response	26	3.289254e-67	1.6647420533076923e-64	3.565403	270	0.0102607	804	0.016369206791044776	1.276784	50	58	0.00394384	
GO Biological Process	regulation of DNA-templated transcription in response to stress	28	1.453667e-66	6.831715733214287e-64	2.41318	496	0.01884928	212	4.482923083066038e-9	1.369056	110	119	0.008676447	
GO Biological Process	response to topologically incorrect protein	30	2.424085e-64	1.0632844838333333e-61	2.14558	614	0.02333359	278	3.718429512302158e-7	1.275365	155	180	0.0122259	
GO Biological Process	response to unfolded protein	34	1.579084e-60	6.1115195164705885e-58	2.157005	570	0.02166147	287	6.087527630662021e-7	1.286679	139	160	0.01096387	
GO Biological Process	nuclear-transcribed mRNA catabolic process	41	5.674455e-56	1.8212232523170732e-53	2.054511	590	0.02242152	174	3.128978783103448e-11	1.323986	177	198	0.01396119	
GO Biological Process	liver regeneration	61	1.634598e-48	3.52617624295082e-46	3.101207	234	0.008892605	491	0.000505595580407332	1.438753	34	35	0.002681811	
GO Biological Process	mitochondrial membrane organization	63	1.346862e-47	2.813231279047619e-45	2.058856	497	0.01888728	363	0.00001512704988980716	1.289964	108	124	0.008518694	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	66	1.173621e-46	2.339951324090909e-44	2.41055	345	0.01311089	217	6.020442007419355e-9	1.368107	109	118	0.008597571	
GO Biological Process	regulation of mitochondrial membrane permeability	73	2.749655e-45	4.95653563630137e-43	2.376754	344	0.01307289	547	0.0015292494891773311	1.298472	64	73	0.005048115	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	80	7.272914e-43	1.1963034415750001e-40	2.446383	307	0.01166679	303	0.0000012889118898679867	1.386129	73	78	0.005758006	
GO Biological Process	response to epidermal growth factor	95	4.546711e-40	6.297912636736842e-38	2.400279	297	0.01128677	897	0.02929816875473801	1.304752	37	42	0.002918441	
GO Biological Process	regulation of membrane permeability	96	5.813738e-40	7.969060243958334e-38	2.187405	360	0.01368093	504	0.0006649832766269841	1.298221	71	81	0.005600252	
GO Biological Process	cotranslational protein targeting to membrane	129	1.665232e-33	1.6986657277519378e-31	2.286011	272	0.0103367	383	0.00002992894985195822	1.314827	87	98	0.006862281	
GO Biological Process	protein targeting to ER	134	3.306506e-33	3.2470382428358207e-31	2.241553	281	0.01067873	294	8.850850820408163e-7	1.349093	92	101	0.007256665	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	146	4.561174e-32	4.110992374383562e-30	2.799987	178	0.00676446	852	0.022127615296948358	1.416675	22	23	0.001735289	
GO Cellular Component	endopeptidase complex	44	2.798486e-30	1.0990417745454547e-28	2.374755	226	0.008588584	96	0.0000100936782	1.373746	64	69	0.005048115	
GO Cellular Component	proteasome complex	47	8.327204e-29	3.0615762791489365e-27	2.334042	222	0.008436574	99	0.0000135009024	1.372167	63	68	0.004969238	
GO Cellular Component	mitochondrial ribosome	48	1.52322e-27	5.483592000000001e-26	2.400555	200	0.007600517	82	0.0000022728257560975607	1.359099	78	85	0.00615239	
GO Cellular Component	peptidase complex	49	3.085549e-27	1.0881283004081632e-25	2.080746	270	0.0102607	102	0.00001607056263529412	1.329597	79	88	0.006231267	
GO Cellular Component	proteasome core complex	55	3.345925e-25	1.0512288e-23	4.171877	80	0.003040207	189	0.009192137142857144	1.419358	23	24	0.001814166	
GO Cellular Component	nuclear ubiquitin ligase complex	59	8.190013e-24	2.3987021125423732e-22	2.732105	135	0.005130349	213	0.028010003830985914	1.295936	35	40	0.002760688	
GO Cellular Component	mitochondrial large ribosomal subunit	93	1.689605e-17	3.1393950967741936e-16	2.423284	120	0.00456031	136	0.00039917498823529413	1.364907	47	51	0.003707209	
GO Cellular Component	spliceosomal tri-snRNP complex	145	8.869578e-13	1.057009019586207e-11	2.441862	83	0.003154214	232	0.04321542537931035	1.327855	26	29	0.002050797	
GO Cellular Component	DNA-directed RNA polymerase III complex	154	6.678773e-12	7.49410372987013e-11	3.285897	47	0.001786121	234	0.042864516923076926	1.403119	18	19	0.001419782	
GO Cellular Component	MLL1 complex	202	3.434764e-9	2.9382535603960395e-8	2.076538	80	0.003040207	232	0.04321542537931035	1.327855	26	29	0.002050797	
GO Cellular Component	Fanconi anaemia nuclear complex	213	9.320902e-9	7.561745847887323e-8	2.156927	69	0.002622178	237	0.04410076192405063	1.48107	13	13	0.001025398	
GO Cellular Component	anaphase-promoting complex	261	8.544344e-7	0.000005656944993103448	2.161702	50	0.001900129	165	0.0027266939345454546	1.48107	21	21	0.001656413	
GO Molecular Function	unfolded protein binding	9	7.441148e-48	3.4907252062222227e-45	2.52996	323	0.01227483	70	0.000021352535805714285	1.313401	94	106	0.007414419	
GO Molecular Function	rRNA binding	24	5.95953e-24	1.0483806525000001e-21	2.684479	140	0.005320362	92	0.00044607825526086955	1.357647	55	60	0.004338224	
GO Molecular Function	NF-kappaB binding	62	1.223532e-14	8.331858232258065e-13	2.313046	108	0.004104279	157	0.0456353559745223	1.375279	26	28	0.002050797	
GO Molecular Function	thyroid hormone receptor binding	160	4.98866e-10	1.3163826575000002e-8	2.029275	94	0.003572243	157	0.0456353559745223	1.375279	26	28	0.002050797	
Human Phenotype	Increased serum lactate	13	2.363982e-29	1.213450145076923e-26	2.078822	293	0.01113476	54	1.1244609277222222e-7	1.377395	93	100	0.007335542	
Human Phenotype	Abnormal CSF metabolite level	20	2.393642e-21	7.986386532999999e-19	2.248831	174	0.00661245	104	0.00004100108714134615	1.387033	59	63	0.004653731	
Human Phenotype	Exercise intolerance	28	8.547985e-19	2.037167996607143e-16	2.089279	179	0.006802463	149	0.00045582456865771815	1.332963	63	70	0.004969238	
Human Phenotype	Increased CSF lactate	43	1.557354e-16	2.4167961027906977e-14	2.126435	149	0.005662385	126	0.00017516900393650794	1.378927	54	58	0.004259347	
Human Phenotype	Abnormality of transition element cation homeostasis	59	1.017573e-14	1.15089231e-12	2.742641	79	0.003002204	223	0.0050161629246636774	1.429998	28	29	0.00220855	
Human Phenotype	External ophthalmoplegia	80	5.478493e-14	4.569747973625e-12	2.094373	128	0.004864331	263	0.0114866459365019	1.388503	30	32	0.002366304	
Human Phenotype	Increased serum ferritin	94	2.688541e-13	1.908578095e-11	2.998756	61	0.002318158	257	0.010017582898443579	1.48107	20	20	0.001577536	
Human Phenotype	Abnormality of iron homeostasis	102	4.890135e-13	3.199203025e-11	2.693463	71	0.002698183	301	0.0222889284717608	1.419358	23	24	0.001814166	
Human Phenotype	Glycosuria	159	5.784291e-11	2.4275832605660373e-9	2.017401	106	0.004028274	223	0.0050161629246636774	1.429998	28	29	0.00220855	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	390	2.583853e-7	0.000004421038735641026	2.400301	44	0.001672114	289	0.01955966208235294	1.48107	18	18	0.001419782	
Mouse Phenotype Single KO	ruffled hair	298	9.735723e-13	2.991611258758389e-11	2.197054	103	0.003914266	246	0.02622319124390244	1.421827	24	25	0.001893043	
Mouse Phenotype Single KO	increased cellular sensitivity to ultraviolet irradiation	396	1.366182e-10	3.159123377272727e-9	2.1866	84	0.003192217	263	0.03500515676806084	1.419358	23	24	0.001814166	
Mouse Phenotype	pancytopenia	118	2.105162e-25	1.7057164306779662e-23	2.520671	167	0.006346432	399	0.029314241661654132	1.378927	27	29	0.002129673	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	159	6.298584e-21	3.7874692845283022e-19	2.67129	122	0.004636315	243	0.0045934781839506176	1.431701	29	30	0.002287427	
Mouse Phenotype	increased incidence of tumors by ionizing radiation induction	726	1.487058e-7	0.0000019583693578512396	2.132719	59	0.002242152	340	0.016076312517352944	1.48107	19	19	0.001498659