# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	15	6.336767e-46	5.559034463533333e-43	2.088219	455	0.04450313	50	9.417991044799999e-14	1.511854	234	396	0.03188445	
GO Biological Process	rRNA metabolic process	19	2.99078e-39	2.071351264210526e-36	2.298144	314	0.03071205	71	4.507628423661972e-11	1.570676	159	259	0.02166508	
GO Biological Process	rRNA processing	21	4.080557e-39	2.5569547410952382e-36	2.31954	307	0.03002739	80	1.6067680163875002e-10	1.563542	154	252	0.02098379	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	22	5.054646e-39	3.023367577909091e-36	2.903724	205	0.02005086	277	0.001144358420902527	1.494359	66	113	0.008993051	
GO Biological Process	mRNA catabolic process	27	3.16242e-37	1.5412698066666667e-34	2.334067	288	0.02816901	153	0.0000020536890072549022	1.477457	123	213	0.01675978	
GO Biological Process	RNA catabolic process	30	1.541932e-35	6.763427729333332e-33	2.186768	315	0.03080986	144	6.610087364444445e-7	1.465046	138	241	0.01880365	
GO Biological Process	regulation of DNA-templated transcription in response to stress	32	1.568261e-34	6.4489832809375e-32	2.642144	211	0.02063772	274	0.0010672928721167884	1.483513	69	119	0.009401826	
GO Biological Process	nuclear-transcribed mRNA catabolic process	33	2.193074e-34	8.745048716969698e-32	2.348139	262	0.02562598	159	0.0000036061378785534594	1.486011	115	198	0.01566971	
GO Biological Process	liver regeneration	41	3.97158e-29	1.2746834443902439e-26	3.683874	108	0.01056338	421	0.01222481414655582	1.754416	24	35	0.0032702	
GO Biological Process	regulation of nuclease activity	48	1.056306e-27	2.8958188862499998e-25	4.682003	78	0.007629108	583	0.04043446960548885	1.771285	18	26	0.00245265	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	50	1.249137e-27	3.2874787566000004e-25	2.769388	154	0.0150626	242	0.000356793126	1.517768	70	118	0.009538084	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	51	1.293046e-27	3.3363122184313726e-25	2.215939	235	0.02298513	312	0.002033417250192308	1.403061	85	155	0.01158196	
GO Biological Process	macromolecular complex disassembly	54	7.0358e-27	1.714520225925926e-24	2.110193	255	0.02494131	149	0.0000012286019575838926	1.513681	113	191	0.01539719	
GO Biological Process	regulation of cellular amino acid metabolic process	55	7.182722e-27	1.7184988872363637e-24	3.717675	98	0.00958529	593	0.04309124250758853	1.492472	35	60	0.004769042	
GO Biological Process	multi-organism metabolic process	66	1.512439e-25	3.0154825456060604e-23	2.358024	190	0.01858372	196	0.000040644619554081635	1.514228	87	147	0.01185448	
GO Biological Process	viral gene expression	67	1.547524e-25	3.0393833307462685e-23	2.589575	159	0.01555164	199	0.00004597451744623116	1.55123	77	127	0.01049189	
GO Biological Process	cotranslational protein targeting to membrane	73	1.358717e-24	2.4492269867123287e-22	2.833653	131	0.01281299	177	0.000009601289640112995	1.670872	64	98	0.008720534	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	74	2.064091e-24	3.670455874189189e-22	2.768763	135	0.01320423	399	0.009577605005263157	1.508873	46	78	0.006267884	
GO Biological Process	protein targeting to ER	75	1.472303e-23	2.583204690266667e-21	2.730614	133	0.01300861	197	0.0000439551346142132	1.621242	64	101	0.008720534	
GO Biological Process	translational elongation	81	4.192355e-23	6.810765363580247e-21	2.587916	143	0.0139867	298	0.0016122760061744966	1.484857	65	112	0.008856792	
GO Cellular Component	ribosome	35	3.878652e-30	1.9149459017142859e-28	2.155308	274	0.02679969	54	0.000006610652799999999	1.420197	131	236	0.01784984	
GO Cellular Component	ribosomal subunit	36	1.156227e-28	5.549889599999999e-27	2.372775	212	0.02073552	52	0.000005650357292307693	1.479794	107	185	0.01457964	
GO Cellular Component	large ribosomal subunit	43	5.825716e-22	2.3411249413953487e-20	2.560753	138	0.01349765	59	0.000020712633925423728	1.57961	71	115	0.009674343	
GO Cellular Component	endopeptidase complex	45	4.982965e-21	1.9134585599999998e-19	2.893745	107	0.01046557	111	0.03828517881081082	1.446122	39	69	0.005314075	
GO Cellular Component	peptidase complex	46	2.241065e-19	8.418609391304347e-18	2.499147	126	0.01232394	109	0.036506171889908255	1.395558	48	88	0.006540401	
GO Cellular Component	methyltransferase complex	55	1.030491e-15	3.23761536e-14	2.197338	130	0.01271518	75	0.0016359531264	1.518244	54	91	0.007357951	
GO Cellular Component	catalytic step 2 spliceosome	61	7.79655e-15	2.2085964590163935e-13	2.180596	124	0.01212833	67	0.00047552419343283584	1.545774	58	96	0.007902984	
GO Cellular Component	nuclear chromosome, telomeric region	63	2.686031e-14	7.367399314285714e-13	2.059282	136	0.01330203	80	0.00241097688	1.414941	73	132	0.009946859	
GO Cellular Component	mitochondrial large ribosomal subunit	67	8.030936e-14	2.0712622997014923e-12	3.118461	60	0.005868545	86	0.0037483333953488374	1.655515	33	51	0.004496525	
GO Cellular Component	PcG protein complex	72	1.920049e-12	4.6081176e-11	2.248258	95	0.009291862	105	0.03714510445714286	1.557362	28	46	0.003815234	
GO Cellular Component	cytosolic large ribosomal subunit	82	3.464161e-11	7.300085619512195e-10	2.314693	79	0.007726917	88	0.003981029236363637	1.593834	38	61	0.005177817	
GO Cellular Component	spliceosomal snRNP complex	86	2.841819e-10	5.710073525581396e-9	2.372273	68	0.006651017	83	0.002582672963855422	1.609393	39	62	0.005314075	
GO Cellular Component	cytosolic proteasome complex	94	1.96524e-9	3.612696510638298e-8	4.404547	25	0.002445227	107	0.03684338242990654	2.132102	10	12	0.001362583	
GO Cellular Component	spliceosomal tri-snRNP complex	95	2.168234e-9	3.943903528421053e-8	3.02879	40	0.003912363	124	0.049560781935483876	1.676274	19	29	0.002588909	
GO Cellular Component	small nuclear ribonucleoprotein complex	97	3.045147e-9	5.424756717525773e-8	2.150165	74	0.007237872	76	0.0017725155536842108	1.594442	43	69	0.005859109	
GO Cellular Component	prespliceosome	100	3.732103e-9	6.449073983999999e-8	3.393125	33	0.0032277	79	0.0023999513924050633	2.071185	17	21	0.002316392	
GO Cellular Component	zona pellucida receptor complex	123	2.245861e-8	3.1551608195121957e-7	7.904861	13	0.001271518	116	0.047554262068965514	2.274243	8	9	0.001090067	
GO Cellular Component	proton-transporting ATP synthase complex	125	2.444429e-8	3.3791786496e-7	3.270577	31	0.003032081	104	0.02699604553846154	1.812287	17	24	0.002316392	
GO Cellular Component	mitochondrial proton-transporting ATP synthase complex	133	4.081567e-8	5.302968252631579e-7	3.269839	30	0.002934272	113	0.045839573522123894	1.779842	16	23	0.002180134	
GO Cellular Component	Fanconi anaemia nuclear complex	141	1.158067e-7	0.0000014192480680851065	2.815921	35	0.003423318	99	0.01820550981818182	2.164904	11	13	0.001498842	
GO Molecular Function	structural constituent of ribosome	9	2.235226e-27	1.0485693524444443e-24	2.402781	197	0.01926839	50	0.00029935905231999997	1.452988	92	162	0.01253577	
GO Molecular Function	ribonuclease activity	20	9.561059e-15	2.0183395549e-12	2.166365	125	0.01222613	71	0.00861563321971831	1.473089	57	99	0.007766726	
GO Molecular Function	disordered domain specific binding	23	1.094592e-13	2.009290184347826e-11	2.670152	76	0.00743349	67	0.004840122855223881	1.898259	23	31	0.003133942	
GO Molecular Function	retinoic acid receptor binding	40	4.751125e-11	5.014812437499999e-9	2.561026	64	0.006259781	94	0.03898264226382978	1.842137	18	25	0.00245265	
Human Phenotype	Increased serum lactate	14	5.71705e-16	2.724991046428571e-13	2.264318	124	0.01212833	73	0.008787732203013697	1.483943	58	100	0.007902984	
Human Phenotype	Abnormal CSF metabolite level	25	1.467957e-12	3.9182708244000005e-10	2.528059	76	0.00743349	90	0.015077354336666666	1.583848	39	63	0.005314075	
Human Phenotype	Malnutrition	33	1.315085e-11	2.6592612742424243e-9	5.909964	24	0.002347418	115	0.0315281842173913	2.558523	8	8	0.001090067	
Human Phenotype	Increased CSF lactate	45	8.775536e-11	1.3013144828444444e-8	2.460971	67	0.006553208	129	0.043319496892248066	1.543936	35	58	0.004769042	
Human Phenotype	Progressive microcephaly	74	9.02319e-9	8.13672255e-7	2.026896	80	0.007824726	130	0.044268096829230774	1.586284	31	50	0.004224009	
Human Phenotype	Dysphonia	82	1.590536e-8	0.0000012943471619512196	2.623413	45	0.004401408	122	0.04076425212622951	1.891082	17	23	0.002316392	
Mouse Phenotype Single KO	absent segment of posterior cerebral artery	204	1.420131e-7	0.000006374578219117648	2.547573	41	0.004010172	91	0.03080891769010989	1.97704	17	22	0.002316392	
Mouse Phenotype Single KO	abnormal pharyngeal muscle morphology	315	0.000004657135	0.0001353821752222222	3.041523	23	0.002249609	48	0.006175122150833334	2.558523	11	11	0.001498842	
Mouse Phenotype Single KO	abnormal infrahyoid muscle morphology	379	0.00001797009	0.00043417444361477567	2.953685	21	0.002053991	61	0.012442483563278688	2.558523	10	10	0.001362583	
Mouse Phenotype Single KO	abnormal infrahyoid muscle connection	398	0.00002653889	0.0006105945118844221	2.965647	20	0.001956182	83	0.023413853243373493	2.558523	9	9	0.001226325	
Mouse Phenotype	absent segment of posterior cerebral artery	277	1.420131e-7	0.00000490175902202166	2.547573	41	0.004010172	164	0.017849419240243903	1.97704	17	22	0.002316392	
Mouse Phenotype	abnormal infrahyoid muscle morphology	471	0.00001797009	0.0003647813810828025	2.953685	21	0.002053991	124	0.006390948671612904	2.558523	10	10	0.001362583	
Mouse Phenotype	abnormal pharyngeal muscle morphology	479	0.00002199208	0.0004389692627974948	2.752184	23	0.002249609	157	0.015187484075159238	2.345313	11	12	0.001498842	
Mouse Phenotype	abnormal infrahyoid muscle connection	491	0.00002653889	0.0005167786706517312	2.965647	20	0.001956182	152	0.013349269484210528	2.558523	9	9	0.001226325