# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	RNA catabolic process	16	1.669647e-47	1.3731803045625e-44	2.150209	444	0.03029476	156	3.1018909350641024e-9	1.417204	170	241	0.0181896	
GO Biological Process	mRNA catabolic process	17	2.042721e-47	1.5811862140588236e-44	2.255792	399	0.02722434	175	4.6838107002857145e-8	1.414855	150	213	0.01604965	
GO Biological Process	nuclear-transcribed mRNA catabolic process	19	2.281475e-46	1.5801015539473683e-43	2.313288	370	0.02524563	174	4.478003162413793e-8	1.430719	141	198	0.01508667	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	21	4.954681e-43	3.1046974894761905e-40	2.638263	267	0.01821779	461	0.001616307695878525	1.369029	77	113	0.008238819	
GO Biological Process	rRNA metabolic process	25	8.608285e-39	4.531056892599999e-36	2.052481	402	0.02742904	144	1.1747779493749998e-9	1.411796	182	259	0.01947357	
GO Biological Process	rRNA processing	27	3.98093e-38	1.9401873285185185e-35	2.060847	391	0.02667849	152	2.2565200373026316e-9	1.41115	177	252	0.01893858	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	29	5.079441e-38	2.3048401420344828e-35	2.747341	219	0.01494269	224	0.0000017532816617857144	1.498308	88	118	0.009415793	
GO Biological Process	regulation of DNA-templated transcription in response to stress	30	7.67537e-38	3.3666731276666666e-35	2.410952	276	0.01883188	438	0.0011716806647716893	1.367535	81	119	0.008666809	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	39	2.350246e-35	7.929971054871795e-33	2.151013	327	0.02231168	400	0.0006156510524499999	1.335076	103	155	0.01102076	
GO Biological Process	protein targeting to ER	45	1.775294e-34	5.191354165777778e-32	2.778534	194	0.0132369	198	2.3695989498484848e-7	1.57147	79	101	0.008452814	
GO Biological Process	cellular response to epidermal growth factor stimulus	57	7.81651e-33	1.804516755964912e-30	2.818611	180	0.01228166	853	0.035770157522860495	1.480386	28	38	0.002995934	
GO Biological Process	liver regeneration	58	8.363371e-33	1.8974758446379307e-30	3.331305	140	0.009552402	456	0.0014945645910526314	1.664679	29	35	0.003102932	
GO Biological Process	endoplasmic reticulum unfolded protein response	64	4.161709e-32	8.55686386421875e-30	2.413035	232	0.01582969	497	0.0023760351097384304	1.35702	77	114	0.008238819	
GO Biological Process	RNA phosphodiester bond hydrolysis	65	9.542477e-32	1.9318377668153847e-29	2.324883	247	0.01685317	293	0.000032890273777815704	1.419962	94	133	0.01005778	
GO Biological Process	multi-organism metabolic process	76	7.796644e-30	1.349947873631579e-27	2.216358	256	0.01746725	197	2.3553507850253807e-7	1.47607	108	147	0.01155575	
GO Biological Process	cellular response to topologically incorrect protein	77	8.048299e-30	1.375422942090909e-27	2.192692	262	0.01787664	519	0.0032647200100192684	1.315307	91	139	0.009736786	
GO Biological Process	cotranslational protein targeting to membrane	78	1.167871e-29	1.9702582678205126e-27	2.670878	177	0.01207697	234	0.0000027073045424786326	1.537573	75	98	0.008024823	
GO Biological Process	positive regulation of nuclease activity	82	2.95756e-29	4.746162443902439e-27	5.241348	74	0.005049127	922	0.04991870931670282	1.741215	13	15	0.001390969	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	85	3.663804e-29	5.671999627764705e-27	2.485625	198	0.01350983	209	4.606624647464115e-7	1.549873	81	105	0.008666809	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	87	7.467284e-29	1.1294481627126438e-26	2.706804	168	0.01146288	237	0.000003330414086160338	1.550497	71	92	0.007596833	
GO Cellular Component	ribosomal subunit	38	1.56246e-30	7.105081263157895e-29	2.162748	277	0.01890011	51	2.2064699858823533e-8	1.444376	133	185	0.01423069	
GO Cellular Component	large ribosomal subunit	40	3.953068e-27	1.707725376e-25	2.44656	189	0.01289574	65	0.000007728442781538461	1.467513	84	115	0.008987802	
GO Cellular Component	mitochondrial ribosome	44	1.956103e-20	7.682149963636363e-19	2.629136	122	0.008324236	77	0.00008690744851948052	1.489094	63	85	0.006740852	
GO Cellular Component	peptidase complex	48	1.637944e-18	5.8965984e-17	2.186169	158	0.01078057	92	0.0004736667756521739	1.438329	63	88	0.006740852	
GO Cellular Component	mitochondrial large ribosomal subunit	50	1.325721e-17	4.581691776e-16	3.009349	83	0.00566321	79	0.00013610701367088607	1.615155	41	51	0.004386903	
GO Cellular Component	endopeptidase complex	51	2.53277e-17	8.581620705882354e-16	2.358261	125	0.00852893	136	0.008486520564705882	1.397631	48	69	0.005135887	
GO Cellular Component	endoribonuclease complex	52	3.427991e-17	1.1391477784615382e-15	3.225617	73	0.004980895	175	0.037146796251428575	1.524141	22	29	0.002353948	
GO Cellular Component	proteasome complex	54	3.217615e-16	1.0296368e-14	2.302963	122	0.008324236	143	0.011447801823776225	1.388639	47	68	0.005028889	
GO Cellular Component	PcG protein complex	71	2.649748e-13	6.448964146478874e-12	2.063659	125	0.00852893	184	0.04840688660869565	1.397631	32	46	0.003423925	
GO Cellular Component	cytosolic large ribosomal subunit	72	4.492647e-13	1.07823528e-11	2.187033	107	0.007300764	160	0.021168853199999997	1.383311	42	61	0.004493901	
GO Cellular Component	spliceosomal snRNP complex	77	2.378331e-12	5.337345412987013e-11	2.26331	93	0.006345524	133	0.00732093314887218	1.425809	44	62	0.004707896	
GO Cellular Component	spliceosomal tri-snRNP complex	80	4.00025e-12	8.64054e-11	2.95803	56	0.003820961	145	0.012642834537931035	1.59342	23	29	0.002460946	
GO Cellular Component	outer mitochondrial membrane protein complex	98	2.447073e-10	4.3148389224489796e-9	3.708033	34	0.002319869	125	0.0063327550464	1.875155	14	15	0.001497967	
GO Cellular Component	mitochondrial outer membrane translocase complex	106	1.237346e-9	2.017107441509434e-8	3.94771	29	0.001978712	126	0.006351613714285715	2.009095	11	11	0.001176974	
GO Cellular Component	mitochondrial nucleoid	150	1.498294e-7	0.000001726034688	2.046685	65	0.004435044	174	0.03572659862068966	1.435068	30	42	0.003209929	
GO Cellular Component	pre-autophagosomal structure membrane	193	0.000003129757	0.00002802186578238342	2.464878	34	0.002319869	162	0.021014165333333334	1.757958	14	16	0.001497967	
GO Cellular Component	U1 snRNP	209	0.000009757796	0.00008067689707177034	2.268477	36	0.002456332	123	0.004749006204878049	1.797611	17	19	0.00181896	
GO Cellular Component	BLOC complex	218	0.00001414137	0.00011209306128440367	2.149521	39	0.002661026	181	0.04745699005524862	1.572335	18	23	0.001925958	
GO Cellular Component	prespliceosome	266	0.000125484	0.0008151742556390978	2.151853	30	0.002046943	171	0.03405642442105263	1.62641	17	21	0.00181896	
GO Cellular Component	U2-type prespliceosome	377	0.002226281	0.01020428002122016	2.001255	22	0.001501092	162	0.021014165333333334	1.757958	14	16	0.001497967	
GO Molecular Function	ribonucleoprotein complex binding	10	5.308993e-28	2.2414568446e-25	2.316188	218	0.01487445	53	0.00006318337710943397	1.450042	83	115	0.008880805	
GO Molecular Function	structural constituent of ribosome	11	2.105396e-27	8.080892647272727e-25	2.144143	252	0.01719432	37	1.8516790545945948e-7	1.463415	118	162	0.01262572	
GO Molecular Function	ribonuclease activity	14	1.823122e-26	5.49801506e-24	2.369644	196	0.01337336	59	0.0005079526126440678	1.440866	71	99	0.007596833	
GO Molecular Function	endoribonuclease activity	20	7.977151e-19	1.6839765761e-16	2.560042	117	0.007983079	80	0.0053120095725	1.506821	42	56	0.004493901	
GO Molecular Function	rRNA binding	23	2.692769e-17	4.942987268695653e-15	2.926323	85	0.005799672	110	0.017750182296363635	1.439851	43	60	0.004600899	
GO Molecular Function	exonuclease activity	27	9.643904e-15	1.5080208402962963e-12	2.066076	140	0.009552402	86	0.006423041513953488	1.427515	54	76	0.005777873	
GO Molecular Function	5S rRNA binding	67	1.658255e-9	1.0449481507462687e-7	4.143057	27	0.001842249	111	0.017615952675675676	2.009095	11	11	0.001176974	
GO Molecular Function	protein transmembrane transporter activity	215	0.00001250124	0.00024548946641860463	2.186902	38	0.002592795	113	0.02286666584778761	1.785862	16	18	0.001711962	
Human Phenotype	Increased serum lactate	12	8.496999e-21	4.7250395272499996e-18	2.216513	174	0.01187227	69	0.00006059976634637682	1.48673	74	100	0.007917826	
Human Phenotype	Abnormal CSF metabolite level	15	5.727113e-19	2.5478016699333327e-16	2.622149	113	0.007710153	90	0.00033921142648888887	1.562629	49	63	0.005242885	
Human Phenotype	Increased CSF lactate	25	6.106507e-16	1.62994884844e-13	2.536719	99	0.006754913	114	0.0024955404431578946	1.524141	44	58	0.004707896	
Human Phenotype	Lipid accumulation in hepatocytes	28	2.004755e-15	4.777760755357142e-13	2.073539	146	0.00996179	126	0.0046014767778571435	1.451013	52	72	0.005563878	
Human Phenotype	Abnormality of mitochondrial metabolism	37	1.621575e-13	2.9245324256756757e-11	2.065537	127	0.008665393	75	0.00009315828304	1.572335	54	69	0.005777873	
Human Phenotype	Abnormality of the mitochondrion	43	7.479759e-13	1.1607542280697675e-10	2.018234	127	0.008665393	94	0.000360801017212766	1.528044	54	71	0.005777873	
Human Phenotype	Glycosuria	46	1.121613e-12	1.6270703367391305e-10	2.562826	75	0.005117358	150	0.011016059768666667	1.662699	24	29	0.002567944	
Human Phenotype	Dysphonia	84	4.44518e-10	3.53127215952381e-8	2.480787	61	0.004162118	204	0.03940723794607843	1.659687	19	23	0.002032955	
Human Phenotype	Leukodystrophy	93	1.728552e-9	1.240282526451613e-7	2.01871	89	0.006072598	100	0.0006763846222	1.607276	40	50	0.004279906	
Human Phenotype	Progressive macrocephaly	144	1.225267e-7	0.000005677921313194444	2.529708	42	0.002865721	182	0.02609643108351649	1.674246	20	24	0.002139953	
Human Phenotype	Acute necrotizing encephalopathy	186	5.311885e-7	0.000019057101400537632	2.516687	38	0.002592795	142	0.008728030238028168	1.808185	18	20	0.001925958	
Human Phenotype	Abnormal mitochondria in muscle tissue	202	9.787441e-7	0.00003233247217475247	2.418905	39	0.002661026	204	0.03940723794607843	1.659687	19	23	0.002032955	
Mouse Phenotype Single KO	abnormal embryonic erythropoiesis	155	5.977815e-10	3.531538835806452e-8	2.065388	89	0.006072598	210	0.046259681438095245	1.59342	23	29	0.002460946	
Mouse Phenotype Single KO	increased hemangioma incidence	501	0.00009428409	0.0017232722797005987	2.43879	24	0.001637555	212	0.04758283873113207	1.772731	15	17	0.001604965	
Mouse Phenotype	dry eyes	45	1.8553e-20	3.941894066666666e-18	3.184289	90	0.00614083	405	0.046508433970370376	1.757958	14	16	0.001497967	
Mouse Phenotype	decreased liver cholesterol level	221	2.155111e-9	9.323536774208144e-8	2.056107	84	0.005731441	259	0.008903118295366795	1.63239	26	32	0.002781939	
Mouse Phenotype	absent segment of posterior cerebral artery	238	4.633112e-9	1.8612262114285717e-7	2.427371	56	0.003820961	411	0.04707112927737227	1.643805	18	22	0.001925958