# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	endoplasmic reticulum unfolded protein response	12	1.129343e-41	1.2384187114166666e-38	2.893466	221	0.01898136	235	0.000025970563202978724	1.5229	77	114	0.009245917	
GO Biological Process	positive regulation of nuclease activity	13	2.378952e-41	2.4080484129230774e-38	7.221824	81	0.00695697	407	0.0032218059122113025	2.104371	14	15	0.001681076	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	14	3.530375e-41	3.318300330357143e-38	2.823471	227	0.01949669	293	0.00020599044706484643	1.476518	74	113	0.008885687	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	16	4.878735e-41	4.0124546165625e-38	8.558147	71	0.006098085	643	0.03058546574650078	2.254683	8	8	0.0009606148	
GO Biological Process	IRE1-mediated unfolded protein response	17	6.948631e-40	5.378649137000001e-37	4.029031	135	0.01159495	501	0.009483777976047904	1.51608	39	58	0.004682997	
GO Biological Process	cellular response to topologically incorrect protein	18	1.639771e-39	1.1987636993888889e-36	2.612634	248	0.02130035	250	0.0000496523336036	1.459867	90	139	0.01080692	
GO Biological Process	cellular response to unfolded protein	21	5.828198e-38	3.652059880095238e-35	2.670223	229	0.01966847	252	0.00005602647901190476	1.4907	80	121	0.009606148	
GO Biological Process	regulation of DNA-templated transcription in response to stress	24	2.124155e-36	1.1646564852083334e-33	2.573036	234	0.02009791	251	0.000051112214013147415	1.496806	79	119	0.009486071	
GO Biological Process	response to topologically incorrect protein	30	1.434305e-34	6.291339831666666e-32	2.25873	286	0.02456412	269	0.00009879689147211896	1.390388	111	180	0.01332853	
GO Biological Process	response to unfolded protein	33	4.352122e-33	1.7354416181212124e-30	2.283544	267	0.02293223	257	0.00006368771671595331	1.423269	101	160	0.01212776	
GO Biological Process	regulation of nuclease activity	36	4.228042e-32	1.545466796611111e-29	4.7439	90	0.007729967	445	0.004783624735730337	1.82109	21	26	0.002521614	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	37	4.888236e-32	1.7384945276756757e-29	2.23568	270	0.0231899	329	0.0006138441517629179	1.381902	95	155	0.0114073	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	62	2.666029e-24	5.65843155016129e-22	3.448496	97	0.008331186	459	0.005569063679956427	1.862564	19	23	0.00228146	
GO Biological Process	regulation of cellular amino acid metabolic process	69	6.979077e-23	1.3309807861304346e-20	3.264581	98	0.008417075	714	0.04323739619467787	1.427966	38	60	0.00456292	
GO Biological Process	protein targeting to ER	88	1.080662e-19	1.6159580975e-17	2.433876	135	0.01159495	220	0.000006770520829090909	1.584975	71	101	0.008525456	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	93	7.066326e-19	9.99847138e-17	2.395299	133	0.01142317	497	0.009004865208853118	1.44531	50	78	0.006003842	
GO Biological Process	cellular response to epidermal growth factor stimulus	95	9.384437e-19	1.2998926998210526e-16	2.4639	125	0.01073606	564	0.018363998120035464	1.602012	27	38	0.003242075	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	103	4.666072e-18	5.961246742524272e-16	2.258162	143	0.01228206	338	0.0007668788783136095	1.433061	75	118	0.009005764	
GO Biological Process	protein localization to endoplasmic reticulum	117	6.041378e-17	6.7947430001709405e-15	2.088727	159	0.01365627	221	0.0000068972154212669676	1.527366	84	124	0.01008646	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	121	1.157717e-16	1.2590411572727272e-14	2.196523	139	0.0119385	212	0.0000032117351305188677	1.589015	74	105	0.008885687	
GO Cellular Component	peptidase complex	43	5.174291e-17	2.0793429879069767e-15	2.281647	131	0.0112514	64	0.000050435946	1.562905	61	88	0.007324688	
GO Cellular Component	endopeptidase complex	44	9.456515e-17	3.713831345454546e-15	2.517319	106	0.009104183	85	0.0030586921411764707	1.503122	46	69	0.005523535	
GO Cellular Component	proteasome complex	45	5.861929e-16	2.2509807360000003e-14	2.471218	104	0.008932406	93	0.004261994941935484	1.49207	45	68	0.005403458	
GO Cellular Component	catalytic step 2 spliceosome	49	6.73885e-15	2.376476081632653e-13	2.100141	136	0.01168084	66	0.0000821887330909091	1.526608	65	96	0.007804995	
GO Cellular Component	large ribosomal subunit	52	3.062177e-14	1.0175849723076925e-12	2.102008	129	0.01107962	71	0.00028729630647887324	1.450839	74	115	0.008885687	
GO Cellular Component	PcG protein complex	64	3.943147e-12	1.0646496899999999e-10	2.140502	103	0.008846517	148	0.040579359567567565	1.470445	30	46	0.003602305	
GO Cellular Component	spliceosomal snRNP complex	65	4.429436e-12	1.1775485243076924e-10	2.42013	79	0.006785193	116	0.01607753544827586	1.454634	40	62	0.004803074	
GO Cellular Component	mitochondrial large ribosomal subunit	66	5.223231e-12	1.3675368436363638e-10	2.784036	61	0.0052392	138	0.033649331478260866	1.458913	33	51	0.003962536	
GO Cellular Component	mitochondrial ribosome	68	1.848591e-11	4.697595952941176e-10	2.278678	84	0.007214635	120	0.0187679232	1.379335	52	85	0.006243996	
GO Cellular Component	small nuclear ribonucleoprotein complex	84	7.114305e-10	1.4635141714285716e-8	2.117747	83	0.007128747	130	0.026394561969230772	1.405092	43	69	0.005163305	
GO Cellular Component	proteasome accessory complex	104	3.549591e-8	5.89778196923077e-7	2.859436	37	0.003177875	134	0.02961887426865672	1.691012	18	24	0.002161383	
GO Cellular Component	retromer complex	141	0.000001800244	0.00002206256476595745	2.299279	41	0.003521429	143	0.03752991239160839	1.717854	16	21	0.00192123	
GO Cellular Component	U4 snRNP	162	0.000008542187	0.00009111666133333334	3.819779	16	0.001374216	153	0.04497420423529412	2.029215	9	10	0.001080692	
GO Cellular Component	ESCRT complex	223	0.0001615496	0.0012518282905829598	2.062397	32	0.002748433	147	0.040551070040816324	1.610488	20	28	0.002401537	
GO Cellular Component	signal recognition particle, endoplasmic reticulum targeting	230	0.0001920515	0.0014428912695652176	3.854043	11	0.0009447737	146	0.03990091660273973	2.254683	7	7	0.0008405379	
GO Cellular Component	U1 snRNP	243	0.0002829987	0.0020124352	2.141639	27	0.00231899	135	0.029447424	1.780013	15	19	0.001801153	
GO Cellular Component	U6 snRNP	365	0.005233989	0.024778994498630136	2.412414	12	0.001030662	126	0.02049634285714286	2.254683	8	8	0.0009606148	
GO Molecular Function	unfolded protein binding	12	3.156693e-20	1.1106298205000002e-17	2.442936	138	0.01185262	103	0.02610936037864078	1.361318	64	106	0.007684918	
GO Molecular Function	rRNA binding	17	2.868024e-16	7.122821957647058e-14	3.120229	72	0.006183973	55	0.00037765912821818186	1.653434	44	60	0.005283381	
GO Molecular Function	ribonucleoprotein complex binding	18	2.47615e-15	5.807947388888889e-13	2.032878	152	0.01305505	56	0.00037583256353571423	1.470445	75	115	0.009005764	
GO Molecular Function	snRNA binding	25	1.915339e-13	3.2346245032e-11	3.284719	54	0.00463798	107	0.03105688600560748	1.602012	27	38	0.003242075	
GO Molecular Function	proteasome binding	87	1.494915e-7	0.0000072546334827586214	2.94586	32	0.002748433	110	0.03559295305272727	2.066793	11	12	0.001320845	
Human Phenotype	Increased serum lactate	5	1.342082e-18	1.7911426372000002e-15	2.293019	143	0.01228206	32	0.00000386593582	1.623372	72	100	0.008645533	
Human Phenotype	Abnormality of mitochondrial metabolism	24	3.959009e-13	1.1007694607083333e-10	2.190602	107	0.009190071	67	0.0002009569966119403	1.633828	50	69	0.006003842	
Human Phenotype	Abnormality of the mitochondrion	34	1.540508e-12	3.0234734952941176e-10	2.140435	107	0.009190071	82	0.0006302161859268292	1.587805	50	71	0.006003842	
Human Phenotype	Lipid accumulation in hepatocytes	39	5.775666e-12	9.88231262e-10	2.03805	114	0.009791291	62	0.00016081219648387095	1.628382	52	72	0.006243996	
Human Phenotype	Increased CSF lactate	40	6.179521e-12	1.030898590825e-9	2.451327	76	0.006527527	103	0.0028479612477669905	1.593828	41	58	0.004923151	
Human Phenotype	Abnormal CSF metabolite level	44	4.03525e-11	6.119823465909091e-9	2.307579	79	0.006785193	125	0.0057508127536	1.538911	43	63	0.005163305	
Human Phenotype	Exercise intolerance	47	6.977772e-11	9.906951607659575e-9	2.215872	84	0.007214635	163	0.02476574234417178	1.449439	45	70	0.005403458	
Human Phenotype	Decreased activity of mitochondrial respiratory chain	59	1.431544e-9	1.6191005274576272e-7	3.379239	35	0.003006098	179	0.03474335102122905	1.954059	13	15	0.001560999	
Human Phenotype	Cytochrome C oxidase-negative muscle fibers	97	1.333667e-7	0.000009174804011340206	3.328885	27	0.00231899	171	0.03212816920584795	1.878902	15	18	0.001801153	
Human Phenotype	Increased hepatocellular lipid droplets	209	0.00001568288	0.0005007265944497608	2.982007	21	0.001803659	178	0.03476478921179775	2.066793	11	12	0.001320845	
Human Phenotype	Retinopathy	314	0.0002058891	0.00437547122388535	2.060112	31	0.002662544	156	0.020041281831410258	1.972848	14	16	0.001681076	
Mouse Phenotype Single KO	abnormal oxidative phosphorylation	230	5.859407e-7	0.00002332808256478261	2.027001	60	0.005153311	141	0.018772090290070924	1.634645	29	40	0.003482229	
Mouse Phenotype	abnormal hair follicle outer root sheath morphology	57	6.360466e-15	1.0668844811578945e-12	2.50564	94	0.008073521	140	0.003186688812214286	1.852061	23	28	0.002761768	
Mouse Phenotype	dry skin	207	1.232646e-8	5.693395365217391e-7	2.088473	73	0.006269862	268	0.03291163765298507	1.578278	28	40	0.003362152