# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	rRNA processing	16	2.142162e-49	1.761794359875e-46	2.342312	384	0.03032217	117	1.2100746471794872e-11	1.502922	173	252	0.02017022	
GO Biological Process	ncRNA processing	17	3.883274e-49	3.005882503882353e-46	2.004527	541	0.04271952	76	6.347648808684211e-15	1.453956	263	396	0.0306634	
GO Biological Process	rRNA metabolic process	20	1.92991e-47	1.2697842845e-44	2.286696	387	0.03055907	127	7.355922445669291e-11	1.479207	175	259	0.0204034	
GO Biological Process	mitochondrial transport	26	2.061918e-41	1.0435684216153846e-38	2.095789	408	0.03221731	152	4.461277589802632e-9	1.456431	159	239	0.01853795	
GO Biological Process	mRNA catabolic process	30	3.595374e-39	1.5770508822e-36	2.218046	339	0.02676879	145	9.65504870551724e-10	1.500597	146	213	0.01702227	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	34	1.035317e-36	4.006981295e-34	2.618707	229	0.01808275	391	0.0012672584800767265	1.414279	73	113	0.008511134	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	35	1.233573e-36	4.637882030571428e-34	2.860087	197	0.01555591	176	1.2681418020454546e-7	1.595538	86	118	0.01002682	
GO Biological Process	nuclear-transcribed mRNA catabolic process	37	4.581667e-36	1.6294636771081083e-33	2.228554	308	0.02432091	166	2.2897492346385542e-8	1.481598	134	198	0.01562318	
GO Biological Process	RNA catabolic process	43	7.80735e-35	2.3892306662790697e-32	2.040063	364	0.02874289	164	1.0919282033536584e-8	1.444345	159	241	0.01853795	
GO Biological Process	regulation of DNA-templated transcription in response to stress	46	6.145128e-34	1.757907377217391e-31	2.436357	241	0.01903032	336	0.00036816767160714287	1.434956	78	119	0.009094089	
GO Biological Process	viral gene expression	50	1.729628e-32	4.5520349704e-30	2.629731	200	0.0157928	115	1.0238783326521739e-11	1.706563	99	127	0.0115425	
GO Biological Process	multi-organism metabolic process	51	3.209763e-32	8.281817905294118e-30	2.384633	238	0.01879343	132	1.8192008462878788e-10	1.623304	109	147	0.01270841	
GO Biological Process	translational initiation	53	3.555897e-32	8.828688419433962e-30	2.424791	230	0.01816172	163	1.0827491609202453e-8	1.576856	103	143	0.01200886	
GO Biological Process	mitochondrial membrane organization	54	1.176928e-31	2.8679991762962963e-29	2.255209	262	0.02068857	218	0.000004711042121146789	1.518335	86	124	0.01002682	
GO Biological Process	protein targeting to ER	59	1.164471e-30	2.597165065932203e-28	2.801208	169	0.01334491	155	7.425931026322581e-9	1.69069	78	101	0.009094089	
GO Biological Process	endoplasmic reticulum unfolded protein response	61	1.392245e-30	3.003369172950819e-28	2.49167	207	0.01634555	462	0.0035433968456709958	1.38267	72	114	0.008394544	
GO Biological Process	cellular response to topologically incorrect protein	62	3.490456e-30	7.408211371612903e-28	2.305143	238	0.01879343	566	0.013715093295229682	1.307236	83	139	0.009677043	
GO Biological Process	liver regeneration	63	1.133813e-29	2.3682294074603174e-27	3.387163	123	0.009712571	562	0.013054552193594306	1.626283	26	35	0.003031363	
GO Biological Process	positive regulation of nuclease activity	65	2.847437e-29	5.764526689692307e-27	5.655942	69	0.005448515	474	0.004091741079113923	2.043279	14	15	0.001632272	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	66	3.231135e-29	6.442197797727274e-27	6.649158	60	0.00473784	710	0.03506450929295775	2.189227	8	8	0.0009327271	
GO Cellular Component	ribosomal subunit	32	6.139235e-38	3.3151869e-36	2.439689	270	0.02132028	31	1.3979358348387098e-14	1.644879	139	185	0.01620613	
GO Cellular Component	ribosome	39	2.956685e-29	1.3100388923076922e-27	2.006762	316	0.02495262	36	5.4218448e-13	1.53988	166	236	0.01935409	
GO Cellular Component	large ribosomal subunit	40	1.228668e-27	5.30784576e-26	2.5917	173	0.01366077	47	6.882362961702127e-9	1.637161	86	115	0.01002682	
GO Cellular Component	catalytic step 2 spliceosome	41	2.253836e-26	9.499094165853659e-25	2.498712	176	0.01389766	72	0.000035049912000000004	1.527898	67	96	0.007811589	
GO Cellular Component	mitochondrial ribosome	47	3.66619e-22	1.3479098553191489e-20	2.868108	115	0.009080859	65	0.000007945181833846153	1.596848	62	85	0.007228635	
GO Cellular Component	mitochondrial large ribosomal subunit	51	1.419499e-17	4.809596611764707e-16	3.188986	76	0.006001263	73	0.00004164617293150684	1.717041	40	51	0.004663635	
GO Cellular Component	ficolin-1-rich granule lumen	52	2.409619e-17	8.007349292307693e-16	2.003092	181	0.01429248	108	0.0026462192	1.359439	77	124	0.008977498	
GO Cellular Component	mitochondrial nucleoid	60	6.655566e-15	1.916803008e-13	2.805904	77	0.006080227	58	3.3346497103448277e-7	1.928605	37	42	0.004313863	
GO Cellular Component	endopeptidase complex	62	4.466985e-14	1.2449919483870968e-12	2.292534	105	0.008291219	114	0.005258035705263158	1.459485	46	69	0.005363181	
GO Cellular Component	DNA packaging complex	65	6.731629e-14	1.7895776787692306e-12	2.159051	118	0.009317751	172	0.03240757506976744	1.29008	66	112	0.007694998	
GO Cellular Component	proteasome complex	68	2.303574e-13	5.853788047058824e-12	2.250137	103	0.008133291	122	0.0072790356983606554	1.448753	45	68	0.00524659	
GO Cellular Component	cytosolic large ribosomal subunit	71	3.789659e-13	9.223282749295775e-12	2.294499	97	0.007659507	93	0.00046553304774193553	1.579115	44	61	0.005129999	
GO Cellular Component	small ribosomal subunit	72	4.161484e-13	9.9875616e-12	2.247533	101	0.007975363	63	0.0000028236809142857146	1.672326	55	72	0.006412499	
GO Cellular Component	nuclear ubiquitin ligase complex	78	2.36286e-12	5.2346436923076924e-11	2.733336	65	0.00513266	154	0.018129917922077923	1.532459	28	40	0.003264545	
GO Cellular Component	PcG protein complex	92	4.409887e-11	8.282918191304347e-10	2.025248	106	0.008370183	135	0.011546666240000001	1.522941	32	46	0.003730908	
GO Cellular Component	ESCRT complex	95	5.078489e-11	9.237504202105262e-10	2.96269	50	0.0039482	152	0.017831982315789474	1.64192	21	28	0.002448409	
GO Cellular Component	spliceosomal snRNP complex	97	9.175022e-11	1.6344781459793817e-9	2.253179	80	0.006317119	137	0.011601149991240876	1.447715	41	62	0.004780226	
GO Cellular Component	preribosome	105	2.09586e-10	3.4491867428571427e-9	2.00481	101	0.007975363	153	0.01798084517647059	1.38267	48	76	0.005596362	
GO Cellular Component	proteasome accessory complex	113	4.366299e-10	6.676959886725663e-9	3.05521	43	0.003395452	134	0.011004020059701492	1.733138	19	24	0.002215227	
GO Cellular Component	DNA-directed RNA polymerase III complex	118	1.24279e-9	1.819950101694915e-8	4.067524	28	0.002210992	127	0.008780116308661417	1.84356	16	19	0.001865454	
GO Molecular Function	structural constituent of ribosome	9	3.248072e-28	1.523706664888889e-25	2.264778	230	0.01816172	9	2.5196975748888886e-10	1.608136	119	162	0.01387432	
GO Molecular Function	rRNA binding	11	9.208562e-24	3.534413524e-21	3.585836	90	0.007106759	49	0.00008241531835918368	1.678407	46	60	0.005363181	
GO Molecular Function	ribonucleoprotein complex binding	13	9.045675e-22	2.9377569115384618e-19	2.225566	181	0.01429248	83	0.004492548303373495	1.389683	73	115	0.008511134	
GO Molecular Function	aminoacyl-tRNA editing activity	29	2.084341e-13	3.034513000689655e-11	4.588255	36	0.002842704	105	0.024854286731428574	2.020825	12	13	0.001399091	
GO Molecular Function	RNA polymerase III activity	94	2.310438e-8	0.000001037730769787234	3.875939	25	0.0019741	107	0.026772400405607476	1.915574	14	16	0.001632272	
GO Molecular Function	cyclin-dependent protein serine/threonine kinase regulator activity	105	7.424319e-8	0.000002985283316	2.194165	58	0.004579912	76	0.002502329402631579	1.811774	24	29	0.002798181	
Human Phenotype	Abnormal CNS myelination	8	1.592664e-19	1.328480859e-16	2.031023	199	0.01571383	37	0.00006555663410810811	1.488674	85	125	0.009910225	
Human Phenotype	Progressive external ophthalmoplegia	11	1.144145e-18	6.940799622727272e-16	4.770478	50	0.0039482	83	0.01184968024698795	2.043279	14	15	0.001632272	
Human Phenotype	Increased serum lactate	15	1.051237e-16	4.6766030006666664e-14	2.152378	146	0.01152874	44	0.00030001368188636363	1.510567	69	100	0.008044771	
Human Phenotype	Hypolipoproteinemia	121	4.180067e-7	0.000023052551314876034	2.092934	57	0.004500948	110	0.039146117151818184	1.84356	16	19	0.001865454	
Mouse Phenotype Single KO	decreased circulating free fatty acid level	17	5.920415e-23	3.1890141267647065e-20	2.149887	207	0.01634555	150	0.025292537490666664	1.388864	59	93	0.006878862	
Mouse Phenotype Single KO	abnormal DNA replication	198	3.085659e-8	0.0000014270393668181817	2.503515	47	0.003711308	140	0.020394169527142857	1.808492	19	23	0.002215227	
Mouse Phenotype	decreased circulating free fatty acid level	16	2.312974e-26	1.382146525875e-23	2.057926	266	0.02100442	142	0.0014434948675352112	1.416559	77	119	0.008977498	
Mouse Phenotype	abnormal DNA replication	279	1.008288e-7	0.0000034552837161290323	2.226158	55	0.00434302	205	0.006970477365365854	1.783815	22	27	0.002564999	
Mouse Phenotype	decreased spongiotrophoblast size	563	0.00007586745	0.0012883990931616342	2.048055	36	0.002842704	267	0.023107465250561794	1.84356	16	19	0.001865454