# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA processing	15	1.892102e-27	1.6598780145333335e-24	2.006077	292	0.04275256	117	1.626501886837607e-7	1.469178	175	396	0.03098442	
GO Biological Process	rRNA processing	20	8.764998e-24	5.766930434100001e-21	2.228076	197	0.02884334	131	6.486464865496183e-7	1.569922	119	252	0.02106941	
GO Biological Process	rRNA metabolic process	23	2.584952e-23	1.478929711652174e-20	2.191178	200	0.02928258	137	0.0000010197850400729928	1.553163	121	259	0.02142351	
GO Biological Process	RNA catabolic process	28	8.185226e-22	3.8467638905e-19	2.109543	203	0.02972182	154	0.000002143266998116883	1.558809	113	241	0.02000708	
GO Biological Process	mRNA catabolic process	31	5.596828e-21	2.375763214580645e-18	2.183702	180	0.02635432	173	0.000005145142377745665	1.576425	101	213	0.01788244	
GO Biological Process	nuclear-transcribed mRNA catabolic process	36	6.762813e-20	2.4719960074166667e-17	2.213638	165	0.02415813	176	0.000006076395541818182	1.595107	95	198	0.01682011	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	42	1.491137e-19	4.671874234047619e-17	2.799604	104	0.01522694	195	0.000018455369284102567	1.746792	62	118	0.01097734	
GO Biological Process	DNA replication-dependent nucleosome assembly	43	3.633448e-19	1.1119195867906977e-16	10.26166	28	0.004099561	595	0.04018013291932773	1.870054	18	32	0.003186969	
GO Biological Process	protein-lipid complex assembly	47	1.738331e-18	4.866956942340426e-16	4.458576	53	0.007759883	455	0.010325445055164835	2.063507	18	29	0.003186969	
GO Biological Process	plasma lipoprotein particle assembly	48	1.765168e-18	4.839134523333333e-16	4.907583	48	0.007027818	528	0.021723836710416666	2.045871	16	26	0.002832861	
GO Biological Process	protein targeting to ER	52	9.715871e-18	2.458675894019231e-15	2.827461	92	0.01346999	196	0.00001841146856020408	1.810393	55	101	0.00973796	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	55	5.583016e-17	1.3357619553454544e-14	2.904167	84	0.01229868	227	0.00005910217028634361	1.806815	50	92	0.008852691	
GO Biological Process	cotranslational protein targeting to membrane	59	9.038401e-17	2.015869809474576e-14	2.817051	87	0.01273792	243	0.0000895590709547325	1.764041	52	98	0.009206799	
GO Biological Process	viral gene expression	66	6.705492e-16	1.336932867090909e-13	2.486747	102	0.01493411	275	0.00032536402684727275	1.623004	62	127	0.01097734	
GO Biological Process	viral transcription	67	7.223192e-16	1.4186564705671644e-13	2.552088	97	0.01420205	246	0.00009539510066260163	1.706401	58	113	0.01026912	
GO Biological Process	establishment of protein localization to endoplasmic reticulum	72	3.145616e-15	5.74905013111111e-13	2.532171	94	0.01376281	188	0.000013515244927659573	1.80475	57	105	0.01009207	
GO Biological Process	multi-organism metabolic process	75	9.694187e-15	1.7008774231066666e-12	2.21076	119	0.01742313	291	0.0005315657184879725	1.560498	69	147	0.01221671	
GO Biological Process	RNA phosphodiester bond hydrolysis	79	1.355075e-14	2.2571432816455695e-12	2.262127	112	0.01639824	499	0.01668809348677355	1.449799	58	133	0.01026912	
GO Biological Process	ribonucleoprotein complex export from nucleus	80	1.369984e-14	2.253452432e-12	2.36673	102	0.01493411	368	0.003022035866304348	1.542586	58	125	0.01026912	
GO Biological Process	ribonucleoprotein complex localization	84	4.931777e-14	7.72586351702381e-12	2.305421	103	0.01508053	354	0.0026261375410451975	1.544471	59	127	0.01044618	
GO Cellular Component	ribosomal subunit	30	5.323089e-18	3.0660992639999996e-16	2.29531	137	0.02005857	45	0.00000679264512	1.599373	89	185	0.01575779	
GO Cellular Component	large ribosomal subunit	35	5.250008e-16	2.5920039497142857e-14	2.611059	94	0.01376281	61	0.00024936022977049176	1.647815	57	115	0.01009207	
GO Cellular Component	catalytic step 2 spliceosome	51	2.523866e-12	8.551451858823528e-11	2.316522	88	0.01288433	88	0.031343112	1.489117	43	96	0.007613314	
GO Cellular Component	methyltransferase complex	61	9.35149e-11	2.6490778229508195e-9	2.175966	86	0.01259151	62	0.00037126525935483873	1.71707	47	91	0.00832153	
GO Cellular Component	cytosolic large ribosomal subunit	77	1.825245e-8	4.0961342337662336e-7	2.368428	54	0.007906296	83	0.011341788375903616	1.68952	31	61	0.005488669	
GO Cellular Component	nuclear ubiquitin ligase complex	80	2.803789e-8	6.05618424e-7	2.884905	37	0.005417277	77	0.006338557589610389	1.91161	23	40	0.004072238	
GO Cellular Component	nucleosome	83	3.58237e-8	7.458235373493976e-7	2.298192	55	0.008052709	85	0.020581821741176468	1.488127	47	105	0.00832153	
GO Cellular Component	Holliday junction resolvase complex	94	2.406684e-7	0.000004424202076595745	17.3661	7	0.00102489	92	0.04619133704347826	3.32454	5	5	0.0008852691	
GO Cellular Component	DNA packaging complex	104	4.989949e-7	0.000008290992184615385	2.035552	60	0.008784773	82	0.00813959016585366	1.513853	51	112	0.009029745	
GO Cellular Component	PcG protein complex	113	0.000001199251	0.000018338988743362832	2.019284	57	0.008345534	73	0.003997813216438356	1.879088	26	46	0.004603399	
GO Cellular Component	preribosome	115	0.000001695334	0.000025474236104347828	2.024252	55	0.008052709	91	0.044780227516483515	1.531038	35	76	0.006196884	
GO Cellular Component	cytosolic small ribosomal subunit	165	0.0001006093	0.0010536537599999999	2.064381	34	0.004978038	84	0.012522128914285714	1.813385	24	44	0.004249292	
GO Cellular Component	Lewy body	199	0.0004036077	0.00350469399798995	3.2989	12	0.001756955	87	0.026022667034482756	2.908972	7	8	0.001239377	
GO Molecular Function	structural constituent of ribosome	9	5.135342e-16	2.4090459915555557e-13	2.263965	124	0.0181552	43	0.0002046624318604651	1.580182	77	162	0.01363314	
GO Molecular Function	ribonucleoprotein complex binding	23	5.844085e-12	1.072770733478261e-9	2.188685	96	0.01405564	96	0.036169421014583335	1.474361	51	115	0.009029745	
GO Molecular Function	K63-linked polyubiquitin binding	183	0.0003780491	0.008721985246994536	2.256818	23	0.003367496	91	0.02688678165714286	2.21636	14	21	0.002478754	
Human Phenotype	Exercise intolerance	2	1.265593e-17	4.2226510445e-14	3.28271	73	0.01068814	319	0.0403573835862069	1.567283	33	70	0.005842776	
Human Phenotype	Dysphonia	4	6.944543e-16	1.158523385975e-12	4.188858	48	0.007027818	161	0.0044506298826086955	2.312723	16	23	0.002832861	
Human Phenotype	Increased serum lactate	12	3.599434e-13	2.0015852568333337e-10	2.405462	88	0.01288433	108	0.0014010630799999998	1.66227	50	100	0.008852691	
Human Phenotype	Abnormal CNS myelination	13	7.737405e-13	3.9716695049999997e-10	2.119483	112	0.01639824	200	0.0114925375485	1.489394	56	125	0.009915014	
Human Phenotype	Lactic acidosis	16	1.730154e-12	7.21582352625e-10	2.032639	120	0.01756955	141	0.002829357679148936	1.528803	63	137	0.01115439	
Human Phenotype	Leukoencephalopathy	41	6.873956e-9	0.0000011187782533658536	2.198773	67	0.009809663	97	0.0010714402698969072	1.83594	37	67	0.006550992	
Human Phenotype	Cardiac rhabdomyoma	165	0.00002018697	0.0008164100049090909	4.986125	11	0.001610542	335	0.04898701090447761	3.32454	5	5	0.0008852691	
Human Phenotype	Subependymal cysts	172	0.00002692567	0.001044622069244186	5.338682	10	0.001464129	335	0.04898701090447761	3.32454	5	5	0.0008852691	
Human Phenotype	Weight loss	312	0.0005647017	0.012077738602884617	2.285295	21	0.003074671	310	0.037060292141935486	2.493405	9	12	0.001593484	
Human Phenotype	Paronychia	418	0.002367507	0.03779515361483254	2.996756	10	0.001464129	244	0.020217869074180328	3.32454	6	6	0.001062323	
Mouse Phenotype Single KO	increased skin tumor incidence	5	2.567084e-11	4.7013576376e-8	2.841078	55	0.008052709	138	0.013317303791304348	1.888943	25	44	0.004426346	
Mouse Phenotype	tumor regression	5	7.003015e-13	1.3391165283e-9	8.74619	20	0.002928258	367	0.034132222912806535	2.908972	7	8	0.001239377	
Mouse Phenotype	abnormal bile salt homeostasis	68	5.006241e-7	0.00007038922088382353	2.078615	57	0.008345534	253	0.01021685058853755	1.839107	26	47	0.004603399	
Mouse Phenotype	decreased mitochondrial DNA content	341	0.001673189	0.046913079263929625	2.133675	20	0.002928258	312	0.020531815416346154	2.346734	12	17	0.002124646