# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	ncRNA metabolic process	8	1.052301e-28	1.730903607375e-25	2.051009	286	0.06259575	102	4.882164453333333e-7	1.488526	177	555	0.04399702	
GO Biological Process	translation	12	1.96248e-25	2.15202286e-22	2.183016	219	0.04793171	30	1.1491763472666668e-12	1.831834	146	372	0.03629132	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	13	2.533651e-25	2.564639500692308e-22	3.702121	92	0.0201357	71	5.17646517943662e-8	2.215043	56	118	0.01391996	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	15	1.362098e-23	1.1949231721333333e-20	3.232968	102	0.02232436	94	1.981356229574468e-7	2.18914	53	113	0.01317425	
GO Biological Process	RNA catabolic process	18	5.647477e-23	4.1286194357222224e-20	2.438886	157	0.034362	58	2.0322101649999998e-9	1.897952	98	241	0.02435993	
GO Biological Process	mRNA catabolic process	19	5.735263e-23	3.9721224114210526e-20	2.575187	142	0.03107901	63	7.841076306031745e-9	1.928321	88	213	0.02187422	
GO Biological Process	nuclear-transcribed mRNA catabolic process	21	5.175965e-22	3.243358258809524e-19	2.627202	131	0.02867148	68	2.893979528970588e-8	1.932969	82	198	0.0203828	
GO Biological Process	peptide biosynthetic process	22	1.109789e-21	6.638051568636364e-19	2.007186	225	0.04924491	37	4.750334983243244e-12	1.786	150	392	0.03728561	
GO Biological Process	regulation of DNA-templated transcription in response to stress	23	2.689679e-21	1.538847215695652e-18	2.942138	105	0.02298096	106	5.421293235188678e-7	2.117985	54	119	0.01342282	
GO Biological Process	RNA phosphodiester bond hydrolysis	25	1.265914e-20	6.6632649304e-18	2.989053	99	0.02166776	244	0.0007850767260655738	1.754666	50	133	0.01242854	
GO Biological Process	RNA phosphodiester bond hydrolysis, endonucleolytic	26	1.340575e-20	6.784856317307693e-18	4.00876	67	0.01466404	212	0.0003037653353962264	2.133674	32	70	0.007954263	
GO Biological Process	ncRNA processing	28	8.315045e-20	3.907774184107143e-17	2.033431	198	0.04333552	165	0.00005997341054909091	1.485086	126	396	0.03131991	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to hypoxia	29	9.390786e-20	4.261150102551724e-17	3.487911	76	0.01663384	110	7.029109534363637e-7	2.393545	40	78	0.009942829	
GO Biological Process	RNA splicing, via transesterification reactions	30	1.039569e-19	4.559896157e-17	2.078048	187	0.04092799	61	4.674490984918033e-9	1.798899	111	288	0.02759135	
GO Biological Process	SRP-dependent cotranslational protein targeting to membrane	31	1.068666e-19	4.536314804516129e-17	3.669443	71	0.01553951	74	5.902072901756757e-8	2.384439	47	92	0.01168282	
GO Biological Process	cotranslational protein targeting to membrane	33	2.471746e-19	9.856274428484847e-17	3.533441	73	0.01597724	67	1.9050979566567163e-8	2.381333	50	98	0.01242854	
GO Biological Process	protein targeting to ER	34	3.147766e-19	1.2182780233529413e-16	3.445638	75	0.01641497	79	6.443294355822785e-8	2.3106	50	101	0.01242854	
GO Biological Process	mRNA splicing, via spliceosome	35	7.590797e-19	2.853922792085714e-16	2.050393	184	0.04027139	62	5.105696244838709e-9	1.801457	110	285	0.02734278	
GO Biological Process	nucleic acid phosphodiester bond hydrolysis	37	4.242803e-18	1.5089471534324325e-15	2.119192	163	0.0356752	219	0.0003594327372785388	1.533338	91	277	0.02261994	
GO Biological Process	rRNA metabolic process	38	4.705276e-18	1.6293875495789475e-15	2.276471	139	0.03042241	223	0.00039399845773542596	1.549797	86	259	0.02137708	
GO Cellular Component	intracellular ribonucleoprotein complex	12	9.800829e-44	1.411319376e-41	2.009317	458	0.1002408	21	2.9418788571428573e-16	1.599764	279	814	0.06935123	
GO Cellular Component	ribonucleoprotein complex	13	1.335604e-43	1.7753259323076923e-41	2.006758	458	0.1002408	20	2.720140704e-16	1.599603	280	817	0.0695998	
GO Cellular Component	ribosomal subunit	23	7.135795e-25	5.361153808695653e-23	3.005396	120	0.02626395	30	1.615194432e-7	1.892194	75	185	0.0186428	
GO Cellular Component	ribosome	24	4.497e-23	3.23784e-21	2.552269	145	0.03173561	29	7.837498924137931e-8	1.799723	91	236	0.02261994	
GO Cellular Component	catalytic step 2 spliceosome	31	3.415395e-18	1.903807277419355e-16	3.148062	80	0.0175093	43	0.000010066371572093023	2.090612	43	96	0.01068854	
GO Cellular Component	spliceosomal complex	38	2.982512e-16	1.3562580884210526e-14	2.275653	124	0.02713942	39	0.0000024659308799999998	1.80674	72	186	0.01789709	
GO Cellular Component	proteasome core complex	40	3.663323e-15	1.582555536e-13	7.808733	26	0.005690523	100	0.03167424	2.333706	12	24	0.002982849	
GO Cellular Component	mitochondrial ribosome	41	1.660584e-14	6.998754029268293e-13	3.594602	52	0.01138105	91	0.0198438392967033	1.702233	31	85	0.007705692	
GO Cellular Component	mitochondrial membrane part	42	1.008354e-13	4.148656457142857e-12	2.136117	118	0.02582622	59	0.0008704105871186441	1.563143	71	212	0.01764852	
GO Cellular Component	large ribosomal subunit	43	1.570743e-13	6.312195125581395e-12	2.823562	68	0.01488291	76	0.007111577178947369	1.664034	41	115	0.0101914	
GO Cellular Component	small ribosomal subunit	44	3.472756e-13	1.3638459927272727e-11	3.268966	53	0.01159991	47	0.00003641865885957447	2.204056	34	72	0.008451404	
GO Cellular Component	endopeptidase complex	46	7.043159e-13	2.6457779895652173e-11	3.207392	53	0.01159991	61	0.0009055844616393442	2.02931	30	69	0.007457122	
GO Cellular Component	proteasome complex	49	7.1962e-12	2.537761959183674e-10	3.088102	51	0.01116218	65	0.001758747766153846	1.990514	29	68	0.007208551	
GO Cellular Component	peptidase complex	51	3.917468e-11	1.3273303341176472e-9	2.663007	60	0.01313198	66	0.0018654626618181819	1.856357	35	88	0.008699975	
GO Cellular Component	mitochondrial protein complex	53	1.302005e-10	4.24502762264151e-9	2.135585	88	0.01926023	97	0.027138400329896905	1.478497	51	161	0.01267711	
GO Cellular Component	cytosolic ribosome	55	1.801225e-10	5.6591214545454545e-9	2.326316	72	0.01575837	49	0.00007057014465306123	1.916973	46	112	0.01143425	
GO Cellular Component	inner mitochondrial membrane protein complex	58	7.270127e-10	2.1659964579310342e-8	2.194151	76	0.01663384	94	0.02281467370212766	1.533092	45	137	0.01118568	
GO Cellular Component	U2 snRNP	61	2.290721e-9	6.489124406557378e-8	5.467708	20	0.004377325	56	0.0004404314057142857	3.193493	13	19	0.003231419	
GO Cellular Component	spliceosomal snRNP complex	65	8.825877e-9	2.3463254547692306e-7	2.966463	38	0.008316918	95	0.026453515452631575	1.80674	24	62	0.005965697	
GO Cellular Component	cytosolic small ribosomal subunit	70	2.056709e-8	5.077133074285714e-7	3.085954	34	0.007441453	67	0.0024421653779104473	2.227629	21	44	0.005219985	
GO Molecular Function	structural constituent of ribosome	4	5.730839e-21	6.048900564499999e-18	2.893033	106	0.02319982	7	2.1295611182857144e-7	2.016783	70	162	0.01739995	
GO Molecular Function	ribonuclease activity	6	7.632993e-18	5.3710827409999995e-15	3.102496	80	0.0175093	25	0.014943321467999999	1.791532	38	99	0.009445687	
GO Molecular Function	endoribonuclease activity	8	4.094821e-17	2.16104178275e-14	3.930461	56	0.01225651	17	0.006588565110588235	2.167013	26	56	0.006462839	
GO Molecular Function	nuclease activity	9	1.412462e-16	6.626016182222223e-14	2.209067	135	0.02954695	19	0.00660384796631579	1.563143	71	212	0.01764852	
GO Molecular Function	ribonucleoprotein complex binding	11	9.332579e-16	3.5820135034545453e-13	2.794637	82	0.01794703	18	0.006585553003333334	1.785793	44	115	0.01093711	
GO Molecular Function	unfolded protein binding	12	1.13365e-15	3.9885585833333334e-13	3.112619	69	0.01510177	21	0.007769477196190476	1.80532	41	106	0.0101914	
GO Molecular Function	endonuclease activity	20	1.175219e-10	2.4808873090000003e-8	2.173209	85	0.01860363	40	0.047807553125	1.590378	46	135	0.01143425	
GO Molecular Function	RNA-DNA hybrid ribonuclease activity	130	0.0002998098	0.009736899812307692	3.957296	10	0.002188663	16	0.00544606071125	4.667412	7	7	0.001739995	
Mouse Phenotype Single KO	abnormal telomere morphology	81	0.00003897587	0.004406198044320988	2.881049	20	0.004377325	55	0.04177979479636364	2.638103	13	23	0.003231419	
Mouse Phenotype Single KO	increased fibroblast apoptosis	192	0.0007826665	0.03732748510677083	2.060655	25	0.005471657	38	0.021143664813421052	2.400384	18	35	0.004474273	
Mouse Phenotype	increased fibroblast apoptosis	93	0.00005095329	0.005238326942903226	2.16808	33	0.007222587	41	0.009579809518536585	2.236468	23	48	0.005717127	
Mouse Phenotype	pale lung	171	0.0004981254	0.027851327189473682	3.704303	10	0.002188663	53	0.017397920792830188	4.667412	6	6	0.001491424