# GREAT version 4.0.4	Species assembly: hg38	Association rule: Basal+extension: 5000 bp upstream, 1000 bp downstream, 1000000 bp max extension, curated regulatory domains included
# Ontology	 Term Name 	 Binom Rank 	 Binom Raw P-Value 	  Binom FDR Q-Val  	 Binom Fold Enrichment 	 Binom Observed Region Hits 	 Binom Region Set Coverage 	 Hyper Rank 	  Hyper FDR Q-Val  	 Hyper Fold Enrichment 	 Hyper Observed Gene Hits 	 Hyper Total Genes 	 Hyper Gene Set Coverage
GO Biological Process	IRE1-mediated unfolded protein response	6	1.839042e-37	4.033325613e-34	3.682996	141	0.01059911	402	0.0013154181580099502	1.550382	43	58	0.004788952	
GO Biological Process	regulation of transcription from RNA polymerase II promoter in response to stress	8	1.494997e-36	2.459083190375e-33	2.569122	236	0.01774036	491	0.0062010192875763745	1.350961	73	113	0.008130081	
GO Biological Process	activation of signaling protein activity involved in unfolded protein response	9	1.518292e-36	2.219911603111111e-33	7.384732	70	0.005261971	755	0.047575466899337754	2.091213	8	8	0.0008909678	
GO Biological Process	endoplasmic reticulum unfolded protein response	10	5.650415e-36	7.435381098499999e-33	2.601161	227	0.01706382	216	9.620435241666666e-7	1.540894	84	114	0.009355162	
GO Biological Process	liver regeneration	15	1.101232e-33	9.660741258666668e-31	3.512829	134	0.01007292	652	0.026633634357361963	1.553472	26	35	0.002895645	
GO Biological Process	cellular response to topologically incorrect protein	18	1.001409e-32	7.320856128333334e-30	2.332721	253	0.01901827	218	0.0000010169492504587157	1.489425	99	139	0.01102573	
GO Biological Process	response to topologically incorrect protein	20	2.400883e-32	1.57966096985e-29	2.122032	307	0.0230775	205	4.88585132697561e-7	1.440613	124	180	0.01381	
GO Biological Process	regulation of DNA-templated transcription in response to stress	24	1.203054e-31	6.5962448275e-29	2.338576	243	0.01826656	502	0.0077694353414342636	1.335564	76	119	0.008464194	
GO Biological Process	cellular response to unfolded protein	25	2.167411e-31	1.14083845396e-28	2.377844	233	0.01751485	191	1.5042617841361255e-7	1.555448	90	121	0.01002339	
GO Biological Process	regulation of intrinsic apoptotic signaling pathway	26	2.574539e-31	1.3030137961923079e-28	2.130632	294	0.02210028	272	0.00004360898889227942	1.403136	104	155	0.01158258	
GO Biological Process	response to unfolded protein	28	3.759192e-30	1.766685983142857e-27	2.125846	284	0.02134857	187	9.624823334224599e-8	1.489989	114	160	0.01269629	
GO Biological Process	negative regulation of intrinsic apoptotic signaling pathway	42	2.192534e-24	6.869417834761904e-22	2.264905	197	0.01480869	458	0.003702255918558952	1.401558	63	94	0.007016372	
GO Biological Process	mitochondrial membrane organization	45	5.801348e-24	1.6964430740444444e-21	2.032163	248	0.01864241	219	0.0000010181617020091323	1.517816	90	124	0.01002339	
GO Biological Process	regulation of endoplasmic reticulum unfolded protein response	59	2.305611e-21	5.142294093050847e-19	3.08041	99	0.00744193	767	0.049062070500651894	1.636601	18	23	0.002004678	
GO Biological Process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	64	7.195007e-21	1.479360892390625e-18	2.898062	106	0.007968127	638	0.025097038678683386	1.603263	23	30	0.002561532	
GO Biological Process	negative regulation of Notch signaling pathway	71	3.869115e-20	7.170941448591548e-18	2.828945	106	0.007968127	300	0.00007570903446333333	1.837732	29	33	0.003229758	
GO Biological Process	protein targeting to ER	75	1.769981e-19	3.105490663866667e-17	2.319515	147	0.01105014	259	0.000025010559357142855	1.511471	73	101	0.008130081	
GO Biological Process	negative regulation of response to endoplasmic reticulum stress	76	2.208398e-19	3.8237249055263165e-17	2.67054	112	0.008419154	654	0.02697065823088685	1.516129	29	40	0.003229758	
GO Biological Process	regulation of mitochondrial membrane permeability	77	4.294937e-19	7.339879997792208e-17	2.200336	161	0.01210253	360	0.0005288349885833333	1.518278	53	73	0.005902662	
GO Biological Process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	82	7.92403e-19	1.2716135459756096e-16	2.197513	159	0.01195219	293	0.00006544770120477815	1.453216	82	118	0.00913242	
GO Cellular Component	endopeptidase complex	31	3.249695e-22	1.8114428903225808e-20	2.681251	129	0.009697061	104	0.003434720676923077	1.454757	48	69	0.005345807	
GO Cellular Component	proteasome complex	32	8.412713e-22	4.5428650200000005e-20	2.661969	128	0.00962189	109	0.004832407486238532	1.445397	47	68	0.005234436	
GO Cellular Component	peptidase complex	35	8.577275e-21	4.2347232e-19	2.347541	154	0.01157634	78	0.00011066138584615385	1.497118	63	88	0.007016372	
GO Cellular Component	nuclear ubiquitin ligase complex	46	1.547222e-15	5.81217307826087e-14	2.962325	74	0.005562655	84	0.0006072642514285715	1.67297	32	40	0.003563871	
GO Cellular Component	PcG protein complex	47	9.241105e-15	3.3975807319148935e-13	2.200793	121	0.009095693	79	0.00011934521681012658	1.682062	37	46	0.004120726	
GO Cellular Component	mitochondrial ribosome	50	2.309587e-14	7.981932672000001e-13	2.374209	100	0.007517101	116	0.008655438786206896	1.37774	56	85	0.006236775	
GO Cellular Component	mitochondrial large ribosomal subunit	54	3.569874e-13	1.14235968e-11	2.756192	69	0.0051868	123	0.01157196503414634	1.47615	36	51	0.004009355	
GO Cellular Component	preribosome, large subunit precursor	136	0.00000305703	0.000038842263529411765	2.302694	39	0.00293167	103	0.0034648849398058253	1.756619	21	25	0.002338791	
GO Cellular Component	ESCRT complex	165	0.00001911131	0.00020014753745454543	2.143489	38	0.002856499	155	0.03556624227096774	1.56841	21	28	0.002338791	
GO Cellular Component	proton-transporting two-sector ATPase complex, catalytic domain	181	0.00004272782	0.0004079208450828729	2.413758	27	0.002029617	120	0.00929807712	1.845188	15	17	0.001670565	
GO Molecular Function	unfolded protein binding	6	2.203887e-23	1.5508018189999998e-20	2.46346	159	0.01195219	88	0.0054449790636363635	1.38099	70	106	0.007795968	
GO Molecular Function	ribonucleoprotein complex binding	7	1.188013e-20	7.165415551428571e-18	2.153778	184	0.01383147	69	0.0015543727437681162	1.400203	77	115	0.008575565	
GO Molecular Function	rRNA binding	49	6.180943e-11	5.325702315510204e-9	2.503302	66	0.004961287	103	0.016911954726213593	1.463849	42	60	0.004677581	
GO Molecular Function	oxidoreductase activity, acting on the CH-NH group of donors	60	1.025306e-9	7.214736553333333e-8	2.445611	60	0.004510261	101	0.014268303342574257	1.703951	22	27	0.002450161	
Human Phenotype	Nevus	11	3.724298e-17	2.259294595818182e-14	2.826812	89	0.00669022	294	0.03294010693877551	1.626499	21	27	0.002338791	
Human Phenotype	Distal upper limb amyotrophy	42	1.80818e-11	2.8728536047619046e-9	4.604719	30	0.00225513	274	0.025200121773722627	1.93035	12	13	0.001336452	
Human Phenotype	Progressive external ophthalmoplegia	64	5.778747e-10	6.02524667671875e-8	3.360585	37	0.002781328	314	0.047146721398089175	1.812384	13	15	0.001447823	
Human Phenotype	Hand muscle atrophy	71	2.156321e-9	2.0266380328169017e-7	4.384648	25	0.001879275	216	0.009206571275	2.091213	11	11	0.001225081	
Human Phenotype	Abnormal CSF metabolite level	91	1.310647e-8	9.610931242857142e-7	2.01963	79	0.00593851	264	0.020837797321212118	1.427336	43	63	0.004788952	
Human Phenotype	Increased CSF lactate	106	4.361979e-8	0.0000027459892327358492	2.032523	72	0.005412313	312	0.046789086932692306	1.40616	39	58	0.004343468	
Mouse Phenotype Single KO	extramedullary hematopoiesis	5	3.685116e-39	6.7489214424e-36	2.427125	282	0.02119823	187	0.03323243259946524	1.320766	72	114	0.00801871	
Mouse Phenotype Single KO	increased embryonic neuroepithelium apoptosis	229	8.312555e-7	0.000033239330189956335	2.26924	45	0.003382696	186	0.03178856488494623	1.845188	15	17	0.001670565	
Mouse Phenotype	embryo tumor	77	8.651248e-13	1.0742153523116883e-10	4.478887	35	0.002630985	355	0.03513839867323944	2.091213	9	9	0.001002339	
Mouse Phenotype	increased embryonic neuroepithelium apoptosis	193	7.022342e-8	0.000003478788179378238	2.215449	57	0.004284748	334	0.028767531835329343	1.67297	20	25	0.00222742	
Mouse Phenotype	abnormal stapedial artery morphology	198	1.135837e-7	0.000005484715937878788	2.256018	53	0.003984064	303	0.021222157269306933	1.777531	17	20	0.001893307	
Mouse Phenotype	absent stapedial artery	221	3.266685e-7	0.000014132477504524888	2.215749	51	0.003833722	346	0.0333671715433526	1.761021	16	19	0.001781936	
Mouse Phenotype	increased cellular sensitivity to ultraviolet irradiation	260	0.00000176868	0.0000650398056923077	2.12224	49	0.00368338	348	0.03343061345689655	1.603263	23	30	0.002561532